| 1995-04-26 | vs OAK | 1 | W 13-1 | 1-0 | 4 | 50,426 | David Cone | Dave Stewart | David Cone | Dave Stewart | | 13 | 1 | 12 |
| 1995-04-27 | vs OAK | 2 | W 7-1 | 2-0 | 3 | 31,070 | Pat Hentgen | Ron Darling | Pat Hentgen | Ron Darling | | 20 | 2 | 18 |
| 1995-04-28 | vs CAL | 3 | L 6-7 | 2-1 | 3 | 36,208 | Juan Guzman | Mark Langston | Mike Butcher | Tony Castillo | Lee Smith | 26 | 9 | 17 |
| 1995-04-29 | vs CAL | 4 | W 3-0 | 3-1 | 3 | 35,278 | Al Leiter | Scott Sanderson | Al Leiter | Scott Sanderson | Darren Hall | 29 | 9 | 20 |
| 1995-04-30 | vs CAL | 5 | L 3-5 | 3-2 | 3 | 35,290 | Danny Darwin | Brian Anderson | Mike Butcher | Paul Menhart | Lee Smith | 32 | 14 | 18 |
| 1995-05-01 | vs CAL | 6 | L 0-2 | 3-3 | 3 | 31,303 | David Cone | Shawn Boskie | Shawn Boskie | David Cone | Lee Smith | 32 | 16 | 16 |
| 1995-05-02 | vs CHA | 7 | W 9-8 | 4-3 | 3 | 34,194 | Pat Hentgen | Alex Fernandez | Mike Timlin | Isidro Marquez | | 41 | 24 | 17 |
| 1995-05-03 | vs CHA | 8 | W 8-7 | 5-3 | 2 | 33,159 | Juan Guzman | Jim Abbott | Paul Menhart | Roberto Hernandez | | 49 | 31 | 18 |
| 1995-05-05 | @ BAL | 9 | L 2-9 | 5-4 | 3 | 37,670 | Al Leiter | Kevin Brown | Kevin Brown | Al Leiter | | 51 | 40 | 11 |
| 1995-05-06 | @ BAL | 10 | W 7-3 | 6-4 | 3 | 40,173 | Danny Darwin | Arthur Rhodes | Danny Darwin | Arthur Rhodes | | 58 | 43 | 15 |
| 1995-05-07 | @ BAL | 11 | L 2-6 | 6-5 | 3 | 44,304 | David Cone | Mike Mussina | Mike Mussina | David Cone | | 60 | 49 | 11 |
| 1995-05-09 | vs NYA | 12 | W 9-6 | 7-5 | 3 | 37,291 | Pat Hentgen | Jack McDowell | Pat Hentgen | Jack McDowell | | 69 | 55 | 14 |
| 1995-05-10 | vs NYA | 13 | L 4-6 | 7-6 | 3 | 38,232 | Juan Guzman | Melido Perez | John Wetteland | Woody Williams | | 73 | 61 | 12 |
| 1995-05-11 | vs NYA | 14 | L 11-12 | 7-7 | 3 | 39,370 | Al Leiter | Jimmy Key | Joe Ausanio | Duane Ward | Steve Howe | 84 | 73 | 11 |
| 1995-05-12 | @ MIL | 15 | L 5-14 | 7-8 | 3 | 12,904 | Danny Darwin | Ricky Bones | Mike Ignasiak | Danny Darwin | | 89 | 87 | 2 |
| 1995-05-13 | @ MIL | 16 | W 10-0 | 8-8 | 3 | 17,984 | David Cone | Angel Miranda | David Cone | Angel Miranda | | 99 | 87 | 12 |
| 1995-05-14 | @ MIL | 17 | W 8-3 | 9-8 | 3 | 13,447 | Pat Hentgen | Cal Eldred | Pat Hentgen | Cal Eldred | | 107 | 90 | 17 |
| 1995-05-15 | @ TEX | 18 | L 4-12 | 9-9 | 3 | 17,982 | Juan Guzman | Bob Tewksbury | Bob Tewksbury | Juan Guzman | | 111 | 102 | 9 |
| 1995-05-16 | @ TEX | 19 | L 1-6 | 9-10 | 3 | 19,014 | Al Leiter | Kenny Rogers | Kenny Rogers | Al Leiter | Terry Burrows | 112 | 108 | 4 |
| 1995-05-17 | @ TEX | 20 | L 7-12 | 9-11 | 3 | 18,910 | Danny Darwin | Kevin Gross | Kevin Gross | Danny Darwin | Ed Vosberg | 119 | 120 | -1 |
| 1995-05-19 | @ DET | 21 | W 4-2 | 10-11 | 3 | 18,558 | David Cone | Mike Moore | David Cone | Mike Moore | | 123 | 122 | 1 |
| 1995-05-20 | @ DET | 22 | L 6-10 | 10-12 | 3 | 18,888 | Pat Hentgen | Brian Bohanon | John Doherty | Pat Hentgen | | 129 | 132 | -3 |
| 1995-05-21 | @ DET | 23 | L 1-2 | 10-13 | 4 | 19,144 | Al Leiter | Sean Bergman | Joe Boever | Danny Cox | Mike Henneman | 130 | 134 | -4 |
| 1995-05-22 | vs KCA | 24 | L 0-7 | 10-14 | 4 | 39,255 | Danny Darwin | Kevin Appier | Kevin Appier | Danny Darwin | | 130 | 141 | -11 |
| 1995-05-23 | vs KCA | 25 | W 10-6 | 11-14 | 4 | 35,049 | Paul Menhart | Jim Pittsley | Mike Timlin | Hipolito Pichardo | Darren Hall | 140 | 147 | -7 |
| 1995-05-24 | vs KCA | 26 | L 5-8 | 11-15 | 4 | 37,277 | David Cone | Tom Gordon | Tom Gordon | David Cone | | 145 | 155 | -10 |
| 1995-05-26 | vs CLE | 27 | L 4-7 | 11-16 | 4 | 47,113 | Pat Hentgen | Orel Hershiser | Orel Hershiser | Pat Hentgen | Jose Mesa | 149 | 162 | -13 |
| 1995-05-27 | vs CLE | 28 | W 3-0 | 12-16 | 4 | 47,143 | Al Leiter | Buddy Black | Al Leiter | Eric Plunk | Darren Hall | 152 | 162 | -10 |
| 1995-05-28 | vs CLE | 29 | L 4-5 | 12-17 | 4 | 42,365 | Danny Darwin | Charles Nagy | Charles Nagy | Danny Darwin | Jose Mesa | 156 | 167 | -11 |
| 1995-05-29 | vs DET | 30 | W 5-4 | 13-17 | 4 | 39,294 | David Cone | Mike Moore | David Cone | Mike Moore | Mike Timlin | 161 | 171 | -10 |
| 1995-05-30 | vs DET | 31 | L 6-8 | 13-18 | 4 | 39,711 | Paul Menhart | Brian Bohanon | Felipe Lira | Danny Cox | Mike Henneman | 167 | 179 | -12 |
| 1995-05-31 | vs DET | 32 | W 5-3 | 14-18 | 3 | 41,232 | Pat Hentgen | Sean Bergman | Pat Hentgen | John Doherty | | 172 | 182 | -10 |
| 1995-06-02 | @ CLE | 33 | W 5-0 | 15-18 | 2 | 41,545 | Al Leiter | Charles Nagy | Al Leiter | Charles Nagy | Mike Timlin | 177 | 182 | -5 |
| 1995-06-03 | @ CLE | 34 | L 0-3 | 15-19 | 3 | 41,566 | Danny Darwin | Dennis Martinez | Dennis Martinez | Danny Darwin | | 177 | 185 | -8 |
| 1995-06-04 | @ CLE | 35 | L 8-9 | 15-20 | 4 | 41,688 | David Cone | Jason Grimsley | Julian Tavarez | Darren Hall | | 185 | 194 | -9 |
| 1995-06-05 | @ CHA | 36 | L 2-3 | 15-21 | 4 | 22,180 | Juan Guzman | Jim Abbott | Jim Abbott | Juan Guzman | Roberto Hernandez | 187 | 197 | -10 |
| 1995-06-06 | @ CHA | 37 | L 4-6 | 15-22 | 4 | 18,428 | Pat Hentgen | Jason Bere | Jason Bere | Pat Hentgen | Roberto Hernandez | 191 | 203 | -12 |
| 1995-06-07 | @ CHA | 38 | W 4-3 | 16-22 | 3 | 19,749 | Al Leiter | Brian Keyser | Al Leiter | Brian Keyser | Mike Timlin | 195 | 206 | -11 |
| 1995-06-10 | @ KCA | 39 | L 2-8 | 16-23 | 4 | 20,883 | Danny Darwin | Kevin Appier | Kevin Appier | Danny Darwin | | 197 | 214 | -17 |
| 1995-06-11 | @ KCA | 40 | L 2-3 | 16-24 | 5 | 16,881 | David Cone | Mark Gubicza | Hipolito Pichardo | Darren Hall | | 199 | 217 | -18 |
| 1995-06-12 | vs BOS | 41 | W 4-3 | 17-24 | 4 | 40,171 | Juan Guzman | Roger Clemens | Mike Timlin | Ken Ryan | | 203 | 220 | -17 |
| 1995-06-13 | vs BOS | 42 | L 7-11 | 17-25 | 5 | 36,297 | Pat Hentgen | Vaughn Eshelman | Mike Maddux | Pat Hentgen | | 210 | 231 | -21 |
| 1995-06-14 | vs BOS | 43 | W 5-3 | 18-25 | 5 | 37,898 | Al Leiter | Tim Wakefield | Al Leiter | Tim Wakefield | Tony Castillo | 215 | 234 | -19 |
| 1995-06-16 | vs TEX | 44 | L 3-7 | 18-26 | 5 | 38,150 | Danny Darwin | Bob Tewksbury | Bob Tewksbury | Danny Darwin | | 218 | 241 | -23 |
| 1995-06-17 | vs TEX | 45 | W 4-3 | 19-26 | 3 | 45,229 | David Cone | Kenny Rogers | David Cone | Kenny Rogers | | 222 | 244 | -22 |
| 1995-06-18 | vs TEX | 46 | W 7-2 | 20-26 | 3 | 40,215 | Juan Guzman | Roger Pavlik | Juan Guzman | Roger Pavlik | | 229 | 246 | -17 |
| 1995-06-20 | vs MIL | 47 | L 3-5 | 20-27 | 4 | 39,456 | Pat Hentgen | Sid Roberson | Sid Roberson | Pat Hentgen | Mike Fetters | 232 | 251 | -19 |
| 1995-06-21 | vs MIL | 48 | L 9-10 | 20-28 | 5 | 40,296 | Al Leiter | Angel Miranda | Bill Wegman | Mike Timlin | Mike Fetters | 241 | 261 | -20 |
| 1995-06-22 | vs MIL | 49 | L 0-9 | 20-29 | 5 | 43,490 | Danny Darwin | Steve Sparks | Steve Sparks | Danny Darwin | | 241 | 270 | -29 |
| 1995-06-23 | @ NYA | 50 | L 2-6 | 20-30 | 5 | 24,499 | David Cone | Jack McDowell | Jack McDowell | David Cone | | 243 | 276 | -33 |
| 1995-06-24 | @ NYA | 51 | L 2-10 | 20-31 | 5 | 28,950 | Juan Guzman | Melido Perez | Melido Perez | Juan Guzman | | 245 | 286 | -41 |
| 1995-06-25 | @ NYA | 52 | L 2-8 | 20-32 | 5 | 26,340 | Pat Hentgen | Sterling Hitchcock | Sterling Hitchcock | Pat Hentgen | | 247 | 294 | -47 |
| 1995-06-26 | @ BOS | 53 | L 3-4 | 20-33 | 5 | 26,716 | Al Leiter | Erik Hanson | Stan Belinda | Tony Castillo | | 250 | 298 | -48 |
| 1995-06-27 | @ BOS | 54 | L 5-6 | 20-34 | 5 | 30,262 | Danny Darwin | Roger Clemens | Derek Lilliquist | Woody Williams | | 255 | 304 | -49 |
| 1995-06-28 | @ BOS | 55 | W 8-4 | 21-34 | 5 | 31,467 | David Cone | Zane Smith | David Cone | Zane Smith | | 263 | 308 | -45 |
| 1995-06-29 | vs BAL | 56 | W 5-1 | 22-34 | 5 | 40,173 | Juan Guzman | Sid Fernandez | Juan Guzman | Sid Fernandez | | 268 | 309 | -41 |
| 1995-06-30 | vs BAL | 57 | W 6-5 | 23-34 | 5 | 38,416 | Pat Hentgen | Arthur Rhodes | Danny Cox | Terry Clark | | 274 | 314 | -40 |
| 1995-07-01 | vs BAL | 58 | L 2-6 | 23-35 | 5 | 43,375 | Al Leiter | Jamie Moyer | Jamie Moyer | Al Leiter | | 276 | 320 | -44 |
| 1995-07-02 | vs BAL | 59 | L 7-9 | 23-36 | 5 | 42,226 | Woody Williams | John DeSilva | Armando Benitez | Tim Crabtree | Doug Jones | 283 | 329 | -46 |
| 1995-07-03 | @ CAL | 60 | L 2-4 | 23-37 | 5 | 17,848 | David Cone | Mark Langston | Mark Langston | David Cone | Lee Smith | 285 | 333 | -48 |
| 1995-07-04 | @ CAL | 61 | L 0-14 | 23-38 | 5 | 61,292 | Juan Guzman | Chuck Finley | Chuck Finley | Juan Guzman | | 285 | 347 | -62 |
| 1995-07-05 | @ CAL | 62 | W 6-5 | 24-38 | 5 | 14,163 | Pat Hentgen | Shawn Boskie | Pat Hentgen | Shawn Boskie | Tony Castillo | 291 | 352 | -61 |
| 1995-07-06 | @ CAL | 63 | L 1-10 | 24-39 | 5 | 15,076 | Al Leiter | Brian Anderson | Brian Anderson | Al Leiter | | 292 | 362 | -70 |
| 1995-07-07 | @ OAK | 64 | W 4-2 | 25-39 | 5 | 14,522 | Woody Williams | Ariel Prieto | Woody Williams | Ariel Prieto | Tony Castillo | 296 | 364 | -68 |
| 1995-07-08 | @ OAK | 65 | W 9-6 | 26-40 | 5 | 0 | David Cone | Doug Johns | David Cone | Mike Harkey | | 305 | 370 | -65 |
| 1995-07-08 | @ OAK | 66 | L 3-6 | 26-40 | 5 | 25,103 | Juan Guzman | Dave Stewart | Dennis Eckersley | Juan Guzman | | 308 | 376 | -68 |
| 1995-07-09 | @ OAK | 67 | W 7-3 | 27-40 | 5 | 20,253 | Pat Hentgen | Ron Darling | Pat Hentgen | Ron Darling | | 315 | 379 | -64 |
| 1995-07-12 | @ OAK | 68 | L 4-7 | 27-41 | 5 | 11,343 | Al Leiter | Todd Stottlemyre | Todd Stottlemyre | Al Leiter | Dennis Eckersley | 319 | 386 | -67 |
| 1995-07-13 | @ SEA | 69 | W 4-1 | 28-41 | 5 | 18,616 | David Cone | Tim Belcher | David Cone | Tim Belcher | Tony Castillo | 323 | 387 | -64 |
| 1995-07-14 | @ SEA | 70 | W 5-1 | 29-41 | 5 | 14,850 | Juan Guzman | Chris Bosio | Juan Guzman | Chris Bosio | | 328 | 388 | -60 |
| 1995-07-15 | @ SEA | 71 | L 0-3 | 29-42 | 5 | 36,037 | Pat Hentgen | Randy Johnson | Randy Johnson | Pat Hentgen | | 328 | 391 | -63 |
| 1995-07-16 | @ SEA | 72 | W 9-3 | 30-42 | 5 | 17,632 | Woody Williams | Rafael Carmona | Edwin Hurtado | Rafael Carmona | | 337 | 394 | -57 |
| 1995-07-17 | @ MIN | 73 | W 6-3 | 31-42 | 5 | 15,415 | Al Leiter | Greg Harris | Al Leiter | Greg Harris | Tony Castillo | 343 | 397 | -54 |
| 1995-07-18 | @ MIN | 74 | W 7-0 | 32-42 | 5 | 16,534 | David Cone | Kevin Tapani | David Cone | Kevin Tapani | | 350 | 397 | -47 |
| 1995-07-19 | vs CAL | 75 | L 2-10 | 32-43 | 5 | 39,139 | Juan Guzman | Russ Springer | Russ Springer | Juan Guzman | | 352 | 407 | -55 |
| 1995-07-20 | vs CAL | 76 | L 3-10 | 32-44 | 5 | 37,194 | Pat Hentgen | Chuck Finley | Mike Butcher | Pat Hentgen | | 355 | 417 | -62 |
| 1995-07-21 | vs SEA | 77 | W 4-3 | 33-44 | 5 | 36,490 | Edwin Hurtado | Salomon Torres | Edwin Hurtado | Salomon Torres | Tony Castillo | 359 | 420 | -61 |
| 1995-07-22 | vs SEA | 78 | L 2-7 | 33-45 | 5 | 43,483 | Al Leiter | Tim Belcher | Tim Belcher | Al Leiter | | 361 | 427 | -66 |
| 1995-07-23 | vs SEA | 79 | L 4-6 | 33-46 | 5 | 39,163 | David Cone | Bill Krueger | Bob Wells | David Cone | Bobby Ayala | 365 | 433 | -68 |
| 1995-07-25 | vs MIN | 80 | L 3-7 | 33-47 | 5 | 37,609 | Juan Guzman | Frankie Rodriguez | Frankie Rodriguez | Juan Guzman | | 368 | 440 | -72 |
| 1995-07-26 | vs MIN | 81 | W 6-2 | 34-47 | 5 | 37,150 | Pat Hentgen | Mike Trombley | Pat Hentgen | Mike Trombley | | 374 | 442 | -68 |
| 1995-07-27 | vs MIN | 82 | W 9-2 | 35-47 | 5 | 42,154 | Edwin Hurtado | Greg Harris | Edwin Hurtado | Greg Harris | | 383 | 444 | -61 |
| 1995-07-28 | vs OAK | 83 | W 3-0 | 36-47 | 5 | 40,461 | Al Leiter | Todd Van Poppel | Al Leiter | Todd Van Poppel | Tony Castillo | 386 | 444 | -58 |
| 1995-07-29 | vs OAK | 84 | W 18-11 | 37-47 | 5 | 41,040 | Giovanni Carrara | Ariel Prieto | Giovanni Carrara | Ariel Prieto | | 404 | 455 | -51 |
| 1995-07-30 | vs OAK | 85 | L 3-11 | 37-48 | 5 | 40,312 | Juan Guzman | Ron Darling | Ron Darling | Juan Guzman | | 407 | 466 | -59 |
| 1995-07-31 | @ BAL | 86 | W 6-3 | 38-48 | 5 | 41,937 | Pat Hentgen | Jamie Moyer | Pat Hentgen | Jamie Moyer | Ricardo Jordan | 413 | 469 | -56 |
| 1995-08-01 | @ BAL | 87 | W 12-10 | 39-48 | 5 | 41,394 | Edwin Hurtado | Kevin Brown | Ken Robinson | Doug Jones | Tony Castillo | 425 | 479 | -54 |
| 1995-08-02 | @ BAL | 88 | L 0-1 | 39-49 | 5 | 40,023 | Paul Menhart | Mike Mussina | Mike Mussina | Paul Menhart | | 425 | 480 | -55 |
| 1995-08-03 | @ BAL | 89 | W 8-2 | 40-49 | 5 | 43,325 | Giovanni Carrara | Rick Krivda | Ricardo Jordan | Terry Clark | | 433 | 482 | -49 |
| 1995-08-04 | vs BOS | 90 | L 1-7 | 40-50 | 5 | 40,137 | Juan Guzman | Erik Hanson | Erik Hanson | Jimmy Rogers | | 434 | 489 | -55 |
| 1995-08-05 | vs BOS | 91 | L 3-9 | 40-51 | 5 | 41,454 | Pat Hentgen | Rheal Cormier | Rheal Cormier | Pat Hentgen | | 437 | 498 | -61 |
| 1995-08-06 | vs BOS | 92 | L 4-6 | 40-52 | 5 | 38,194 | Edwin Hurtado | Zane Smith | Vaughn Eshelman | Edwin Hurtado | Rick Aguilera | 441 | 504 | -63 |
| 1995-08-07 | vs BOS | 93 | L 4-5 | 40-53 | 5 | 42,135 | Al Leiter | Roger Clemens | Stan Belinda | Tim Crabtree | | 445 | 509 | -64 |
| 1995-08-08 | @ MIL | 94 | L 5-6 | 40-54 | 5 | 18,222 | Giovanni Carrara | Ricky Bones | Bill Wegman | Jimmy Rogers | | 450 | 515 | -65 |
| 1995-08-09 | @ MIL | 95 | L 7-12 | 40-55 | 5 | 18,417 | Juan Guzman | Scott Karl | Scott Karl | Juan Guzman | | 457 | 527 | -70 |
| 1995-08-10 | @ MIL | 96 | W 8-4 | 41-55 | 5 | 17,661 | Pat Hentgen | Steve Sparks | Pat Hentgen | Steve Sparks | Tony Castillo | 465 | 531 | -66 |
| 1995-08-11 | @ TEX | 97 | W 14-5 | 42-55 | 5 | 31,269 | Edwin Hurtado | Roger Pavlik | Edwin Hurtado | Roger Pavlik | | 479 | 536 | -57 |
| 1995-08-12 | @ TEX | 98 | L 3-6 | 42-56 | 5 | 40,040 | Al Leiter | Bobby Witt | Bobby Witt | Al Leiter | Roger McDowell | 482 | 542 | -60 |
| 1995-08-13 | @ TEX | 99 | L 1-6 | 42-57 | 5 | 25,308 | Giovanni Carrara | Kevin Gross | Kevin Gross | Giovanni Carrara | | 483 | 548 | -65 |
| 1995-08-15 | @ DET | 100 | L 5-11 | 42-58 | 5 | 19,173 | Pat Hentgen | Felipe Lira | Brian Bohanon | Pat Hentgen | | 488 | 559 | -71 |
| 1995-08-16 | @ DET | 101 | W 7-4 | 43-58 | 5 | 17,551 | Edwin Hurtado | Mike Moore | Edwin Hurtado | Brian Maxcy | Tony Castillo | 495 | 563 | -68 |
| 1995-08-17 | @ DET | 102 | W 3-0 | 44-58 | 4 | 14,629 | Al Leiter | Jose Lima | Al Leiter | Jose Lima | Tony Castillo | 498 | 563 | -65 |
| 1995-08-18 | vs KCA | 103 | L 3-10 | 44-59 | 5 | 41,168 | Giovanni Carrara | Tom Gordon | Tom Gordon | Giovanni Carrara | | 501 | 573 | -72 |
| 1995-08-19 | vs KCA | 104 | W 5-4 | 45-59 | 4 | 40,128 | Paul Menhart | Scott Anderson | Jimmy Rogers | Jeff Montgomery | | 506 | 577 | -71 |
| 1995-08-20 | vs KCA | 105 | W 4-3 | 46-59 | 4 | 39,103 | Pat Hentgen | Jason Jacome | Mike Timlin | Gregg Olson | | 510 | 580 | -70 |
| 1995-08-21 | vs CLE | 106 | L 3-7 | 46-60 | 4 | 39,187 | Edwin Hurtado | Orel Hershiser | Orel Hershiser | Edwin Hurtado | Alan Embree | 513 | 587 | -74 |
| 1995-08-22 | vs CLE | 107 | W 5-4 | 47-60 | 4 | 39,293 | Al Leiter | Dennis Martinez | Tony Castillo | Julian Tavarez | | 518 | 591 | -73 |
| 1995-08-23 | vs CLE | 108 | L 5-6 | 47-61 | 4 | 41,169 | Giovanni Carrara | Mark Clark | Jim Poole | Giovanni Carrara | Jose Mesa | 523 | 597 | -74 |
| 1995-08-25 | vs CHA | 109 | L 7-8 | 47-62 | 4 | 38,684 | Pat Hentgen | Jason Bere | Jason Bere | Pat Hentgen | Roberto Hernandez | 530 | 605 | -75 |
| 1995-08-26 | vs CHA | 110 | W 3-2 | 48-62 | 4 | 45,624 | Edwin Hurtado | Alex Fernandez | Jimmy Rogers | Roberto Hernandez | | 533 | 607 | -74 |
| 1995-08-27 | vs CHA | 111 | W 2-1 | 49-62 | 4 | 40,179 | Al Leiter | Dave Righetti | Al Leiter | Dave Righetti | Tony Castillo | 535 | 608 | -73 |
| 1995-08-28 | @ CLE | 112 | L 1-9 | 49-63 | 4 | 40,283 | Giovanni Carrara | Chad Ogea | Chad Ogea | Giovanni Carrara | | 536 | 617 | -81 |
| 1995-08-29 | @ CLE | 113 | L 1-4 | 49-64 | 4 | 41,257 | Juan Guzman | Mark Clark | Mark Clark | Juan Guzman | | 537 | 621 | -84 |
| 1995-08-30 | @ CLE | 114 | L 3-4 | 49-65 | 4 | 41,807 | Pat Hentgen | Dennis Martinez | Paul Assenmacher | Tony Castillo | | 540 | 625 | -85 |
| 1995-08-31 | @ CLE | 115 | L 4-6 | 49-66 | 4 | 41,746 | Edwin Hurtado | Ken Hill | Jose Mesa | Jimmy Rogers | | 544 | 631 | -87 |
| 1995-09-01 | @ CHA | 116 | L 3-5 | 49-67 | 4 | 18,444 | Al Leiter | Dave Righetti | Brian Keyser | Al Leiter | Roberto Hernandez | 547 | 636 | -89 |
| 1995-09-02 | @ CHA | 117 | L 4-10 | 49-68 | 4 | 24,369 | Jeff Ware | Wilson Alvarez | Wilson Alvarez | Jeff Ware | | 551 | 646 | -95 |
| 1995-09-03 | @ CHA | 118 | L 5-6 | 49-69 | 4 | 23,428 | Juan Guzman | Kirk McCaskill | Bill Simas | Juan Guzman | Roberto Hernandez | 556 | 652 | -96 |
| 1995-09-04 | @ KCA | 119 | W 6-1 | 50-70 | 4 | 0 | Pat Hentgen | Mark Gubicza | Pat Hentgen | Mark Gubicza | Mike Timlin | 562 | 653 | -91 |
| 1995-09-04 | @ KCA | 120 | L 7-9 | 50-70 | 4 | 19,905 | Paul Menhart | Dilson Torres | Mike Magnante | Tony Castillo | Jeff Montgomery | 569 | 662 | -93 |
| 1995-09-05 | @ KCA | 121 | L 8-9 | 50-71 | 5 | 12,443 | Edwin Hurtado | Kevin Appier | Gregg Olson | Ken Robinson | | 577 | 671 | -94 |
| 1995-09-06 | @ KCA | 122 | W 6-2 | 51-71 | 4 | 13,030 | Al Leiter | Tom Gordon | Al Leiter | Tom Gordon | | 583 | 673 | -90 |
| 1995-09-08 | vs DET | 123 | W 9-5 | 52-71 | 4 | 36,490 | Jeff Ware | Felipe Lira | Jeff Ware | Felipe Lira | | 592 | 678 | -86 |
| 1995-09-09 | vs DET | 124 | L 2-5 | 52-72 | 4 | 43,127 | Juan Guzman | Sean Bergman | Sean Bergman | Juan Guzman | Dwayne Henry | 594 | 683 | -89 |
| 1995-09-10 | vs DET | 125 | L 2-5 | 52-73 | 5 | 39,255 | Pat Hentgen | Clint Sodowsky | John Doherty | Mike Timlin | Dwayne Henry | 596 | 688 | -92 |
| 1995-09-11 | vs DET | 126 | L 2-3 | 52-74 | 5 | 32,135 | Paul Menhart | C.J. Nitkowski | Mike Christopher | Jimmy Rogers | Brian Bohanon | 598 | 691 | -93 |
| 1995-09-12 | vs TEX | 127 | L 5-6 | 52-75 | 5 | 32,178 | Al Leiter | Bob Tewksbury | Roger McDowell | Al Leiter | Jeff Russell | 603 | 697 | -94 |
| 1995-09-13 | vs TEX | 128 | L 2-3 | 52-76 | 5 | 32,130 | Jeff Ware | Roger Pavlik | Matt Whiteside | Mike Timlin | | 605 | 700 | -95 |
| 1995-09-14 | vs TEX | 129 | L 1-6 | 52-77 | 5 | 32,143 | Juan Guzman | Bobby Witt | Bobby Witt | Juan Guzman | | 606 | 706 | -100 |
| 1995-09-15 | vs MIL | 130 | L 1-5 | 52-78 | 5 | 34,164 | Pat Hentgen | Scott Karl | Mark Kiefer | Ken Robinson | | 607 | 711 | -104 |
| 1995-09-16 | vs MIL | 131 | W 5-4 | 53-78 | 5 | 43,164 | Paul Menhart | Bob Scanlan | Giovanni Carrara | Bill Wegman | | 612 | 715 | -103 |
| 1995-09-17 | vs MIL | 132 | W 5-0 | 54-78 | 5 | 38,191 | Al Leiter | Brian Givens | Al Leiter | Brian Givens | | 617 | 715 | -98 |
| 1995-09-18 | @ NYA | 133 | L 2-9 | 54-79 | 5 | 15,224 | Jeff Ware | David Cone | David Cone | Danny Cox | | 619 | 724 | -105 |
| 1995-09-19 | @ NYA | 134 | L 3-5 | 54-80 | 5 | 15,772 | Juan Guzman | Andy Pettitte | Andy Pettitte | Juan Guzman | John Wetteland | 622 | 729 | -107 |
| 1995-09-20 | @ NYA | 135 | L 1-2 | 54-81 | 5 | 20,541 | Pat Hentgen | Sterling Hitchcock | Sterling Hitchcock | Pat Hentgen | | 623 | 731 | -108 |
| 1995-09-21 | @ NYA | 136 | L 4-6 | 54-82 | 5 | 17,766 | Paul Menhart | Jack McDowell | Steve Howe | Paul Menhart | John Wetteland | 627 | 737 | -110 |
| 1995-09-23 | @ BOS | 137 | L 0-5 | 55-83 | 5 | 32,791 | Al Leiter | Roger Clemens | Roger Clemens | Al Leiter | | 627 | 742 | -115 |
| 1995-09-23 | @ BOS | 138 | W 8-6 | 55-83 | 5 | 21,266 | Jeff Ware | Tim Wakefield | Jeff Ware | Tim Wakefield | Tony Castillo | 635 | 748 | -113 |
| 1995-09-24 | @ BOS | 139 | W 2-1 | 56-83 | 5 | 32,472 | Juan Guzman | Vaughn Eshelman | Juan Guzman | Rick Aguilera | Mike Timlin | 637 | 749 | -112 |
| 1995-09-26 | vs BAL | 140 | L 0-5 | 56-84 | 5 | 35,414 | Pat Hentgen | Mike Mussina | Mike Mussina | Pat Hentgen | | 637 | 754 | -117 |
| 1995-09-27 | vs BAL | 141 | L 0-7 | 56-85 | 5 | 35,019 | Paul Menhart | Scott Erickson | Scott Erickson | Paul Menhart | | 637 | 761 | -124 |
| 1995-09-29 | vs NYA | 142 | L 3-4 | 56-86 | 5 | 40,318 | Juan Guzman | Andy Pettitte | Andy Pettitte | Tony Castillo | John Wetteland | 640 | 765 | -125 |
| 1995-09-30 | vs NYA | 143 | L 1-6 | 56-87 | 5 | 49,233 | Al Leiter | Scott Kamieniecki | Scott Kamieniecki | Al Leiter | | 641 | 771 | -130 |
| 1995-10-01 | vs NYA | 144 | L 1-6 | 56-88 | 5 | 47,182 | Pat Hentgen | Sterling Hitchcock | Sterling Hitchcock | Pat Hentgen | | 642 | 777 | -135 |