| 1994-04-05 | vs OAK | 1 | W 11-7 | - | | 52,012 | Cal Eldred | Bobby Witt | Mark Kiefer | Steve Ontiveros | | 11 | 7 | 4 |
| 1994-04-07 | vs OAK | 2 | W 12-2 | - | | 17,780 | Bill Wegman | Ron Darling | Bill Wegman | Ron Darling | | 23 | 9 | 14 |
| 1994-04-08 | vs CAL | 3 | W 5-1 | - | | 8,788 | Ricky Bones | Phil Leftwich | Ricky Bones | Phil Leftwich | | 28 | 10 | 18 |
| 1994-04-09 | vs CAL | 4 | L 4-6 | - | | 14,376 | Teddy Higuera | Mark Leiter | Mike Butcher | Mike Fetters | Joe Grahe | 32 | 16 | 16 |
| 1994-04-10 | vs CAL | 5 | L 1-4 | - | | 11,860 | Cal Eldred | Brian Anderson | Brian Anderson | Cal Eldred | Joe Grahe | 33 | 20 | 13 |
| 1994-04-11 | @ TEX | 6 | W 4-3 | - | | 46,056 | Jaime Navarro | Kenny Rogers | Jaime Navarro | Kenny Rogers | Bob Scanlan | 37 | 23 | 14 |
| 1994-04-13 | @ TEX | 7 | L 3-4 | - | | 45,455 | Bill Wegman | Steve Dreyer | Tom Henke | Bob Scanlan | | 40 | 27 | 13 |
| 1994-04-14 | @ TEX | 8 | W 7-2 | - | | 34,427 | Ricky Bones | Kevin Brown | Ricky Bones | Kevin Brown | | 47 | 29 | 18 |
| 1994-04-15 | @ SEA | 9 | L 1-9 | - | | 16,969 | Teddy Higuera | Randy Johnson | Randy Johnson | Teddy Higuera | | 48 | 38 | 10 |
| 1994-04-16 | @ SEA | 10 | W 1-0 | - | | 32,990 | Cal Eldred | Chris Bosio | Cal Eldred | Chris Bosio | Graeme Lloyd | 49 | 38 | 11 |
| 1994-04-17 | @ SEA | 11 | L 3-8 | - | | 18,307 | Jaime Navarro | Dave Fleming | Dave Fleming | Jaime Navarro | | 52 | 46 | 6 |
| 1994-04-19 | vs CHA | 12 | L 2-6 | - | | 15,539 | Ricky Bones | Jason Bere | Jason Bere | Ricky Bones | | 54 | 52 | 2 |
| 1994-04-20 | vs CHA | 13 | L 6-8 | - | | 12,204 | Teddy Higuera | Jack McDowell | Roberto Hernandez | Graeme Lloyd | | 60 | 60 | 0 |
| 1994-04-21 | vs CHA | 14 | W 6-4 | - | | 10,484 | Cal Eldred | Alex Fernandez | Cal Eldred | Alex Fernandez | Graeme Lloyd | 66 | 64 | 2 |
| 1994-04-22 | vs KCA | 15 | W 9-8 | - | | 10,544 | Jaime Navarro | Kevin Appier | Jesse Orosco | Jeff Montgomery | | 75 | 72 | 3 |
| 1994-04-23 | vs KCA | 16 | W 3-2 | - | | 24,363 | Bill Wegman | Tom Gordon | Graeme Lloyd | Stan Belinda | Mike Fetters | 78 | 74 | 4 |
| 1994-04-24 | vs KCA | 17 | W 7-0 | - | | 23,493 | Ricky Bones | Mark Gubicza | Ricky Bones | Mark Gubicza | | 85 | 74 | 11 |
| 1994-04-25 | @ CHA | 18 | W 13-4 | - | | 21,762 | Teddy Higuera | Jack McDowell | Teddy Higuera | Jack McDowell | | 98 | 78 | 20 |
| 1994-04-26 | @ CHA | 19 | L 0-3 | - | | 23,909 | Cal Eldred | Alex Fernandez | Alex Fernandez | Cal Eldred | | 98 | 81 | 17 |
| 1994-04-27 | @ MIN | 20 | L 0-6 | - | | 17,988 | Jaime Navarro | Scott Erickson | Scott Erickson | Jaime Navarro | | 98 | 87 | 11 |
| 1994-04-28 | @ MIN | 21 | W 12-2 | - | | 14,135 | Bill Wegman | Carlos Pulido | Bill Wegman | Carlos Pulido | | 110 | 89 | 21 |
| 1994-04-30 | @ KCA | 22 | W 4-3 | - | | 23,098 | Ricky Bones | Tom Gordon | Jeff Bronkey | Hipolito Pichardo | | 114 | 92 | 22 |
| 1994-05-01 | @ KCA | 23 | L 2-6 | - | | 0 | Cal Eldred | David Cone | David Cone | Cal Eldred | | 116 | 98 | 18 |
| 1994-05-01 | @ KCA | 24 | L 3-7 | - | | 26,190 | Teddy Higuera | Mark Gubicza | Mark Gubicza | Teddy Higuera | | 119 | 105 | 14 |
| 1994-05-03 | vs MIN | 25 | W 7-6 | - | | 12,266 | Bill Wegman | Scott Erickson | Bill Wegman | Scott Erickson | Jeff Bronkey | 126 | 111 | 15 |
| 1994-05-04 | vs MIN | 26 | L 7-8 | - | | 15,847 | Jaime Navarro | Kevin Tapani | Larry Casian | Graeme Lloyd | Rick Aguilera | 133 | 119 | 14 |
| 1994-05-06 | @ TOR | 27 | W 7-1 | - | | 47,150 | Cal Eldred | Dave Stewart | Cal Eldred | Dave Stewart | | 140 | 120 | 20 |
| 1994-05-07 | @ TOR | 28 | L 2-3 | - | | 50,458 | Ricky Bones | Todd Stottlemyre | Tony Castillo | Jeff Bronkey | | 142 | 123 | 19 |
| 1994-05-08 | @ TOR | 29 | L 1-3 | - | | 48,252 | Teddy Higuera | Pat Hentgen | Pat Hentgen | Teddy Higuera | Darren Hall | 143 | 126 | 17 |
| 1994-05-09 | @ BOS | 30 | W 7-4 | - | | 21,844 | Mike Ignasiak | Danny Darwin | Mike Ignasiak | Danny Darwin | | 150 | 130 | 20 |
| 1994-05-10 | @ BOS | 31 | W 9-5 | - | | 20,473 | Jaime Navarro | Gar Finnvold | Jaime Navarro | Greg Harris | | 159 | 135 | 24 |
| 1994-05-11 | @ BOS | 32 | L 1-7 | - | | 21,471 | Cal Eldred | Aaron Sele | Aaron Sele | Cal Eldred | | 160 | 142 | 18 |
| 1994-05-12 | @ BOS | 33 | L 1-3 | - | | 22,126 | Ricky Bones | Roger Clemens | Roger Clemens | Ricky Bones | Jeff Russell | 161 | 145 | 16 |
| 1994-05-13 | vs NYA | 34 | L 4-10 | - | | 20,242 | Teddy Higuera | Terry Mulholland | Bob Wickman | Mike Fetters | | 165 | 155 | 10 |
| 1994-05-14 | vs NYA | 35 | L 2-6 | - | | 29,144 | Mike Ignasiak | Jim Abbott | Donn Pall | Bob Scanlan | | 167 | 161 | 6 |
| 1994-05-15 | vs NYA | 36 | L 1-12 | - | | 32,293 | Jaime Navarro | Scott Kamieniecki | Scott Kamieniecki | Jaime Navarro | | 168 | 173 | -5 |
| 1994-05-17 | @ CLE | 37 | L 3-7 | - | | 41,857 | Cal Eldred | Dennis Martinez | Dennis Martinez | Cal Eldred | | 171 | 180 | -9 |
| 1994-05-18 | @ CLE | 38 | L 3-5 | - | | 28,431 | Ricky Bones | Mark Clark | Mark Clark | Ricky Bones | | 174 | 185 | -11 |
| 1994-05-19 | @ CLE | 39 | L 2-4 | - | | 30,294 | Teddy Higuera | Jack Morris | Eric Plunk | Bob Scanlan | | 176 | 189 | -13 |
| 1994-05-20 | @ DET | 40 | L 4-10 | - | | 19,495 | Mike Ignasiak | John Doherty | John Doherty | Doug Henry | | 180 | 199 | -19 |
| 1994-05-21 | @ DET | 41 | L 6-7 | - | | 28,760 | Jaime Navarro | Mike Moore | Mike Moore | Jaime Navarro | | 186 | 206 | -20 |
| 1994-05-22 | @ DET | 42 | L 6-9 | - | | 26,031 | Cal Eldred | Tim Belcher | Tim Belcher | Cal Eldred | Mike Gardiner | 192 | 215 | -23 |
| 1994-05-23 | vs BAL | 43 | L 3-5 | - | | 10,849 | Ricky Bones | Ben McDonald | Ben McDonald | Ricky Bones | Lee Smith | 195 | 220 | -25 |
| 1994-05-24 | vs BAL | 44 | L 5-13 | - | | 12,420 | Teddy Higuera | Sid Fernandez | Mark Eichhorn | Teddy Higuera | Alan Mills | 200 | 233 | -33 |
| 1994-05-25 | vs BAL | 45 | L 3-6 | - | | 16,846 | Mike Ignasiak | Jamie Moyer | Jamie Moyer | Mike Ignasiak | Lee Smith | 203 | 239 | -36 |
| 1994-05-27 | vs SEA | 46 | W 5-2 | - | | 35,495 | Cal Eldred | Chris Bosio | Cal Eldred | Bill Risley | Mike Fetters | 208 | 241 | -33 |
| 1994-05-28 | vs SEA | 47 | W 7-5 | - | | 28,011 | Ricky Bones | John Cummings | Ricky Bones | John Cummings | Mike Fetters | 215 | 246 | -31 |
| 1994-05-29 | vs SEA | 48 | W 9-8 | - | | 47,119 | Teddy Higuera | Roger Salkeld | Doug Henry | Tim Davis | Bob Scanlan | 224 | 254 | -30 |
| 1994-05-30 | vs TEX | 49 | L 4-5 | - | | 14,605 | Bill Wegman | Kevin Brown | Kevin Brown | Mike Fetters | Jay Howell | 228 | 259 | -31 |
| 1994-05-31 | vs TEX | 50 | L 4-7 | - | | 11,334 | Jaime Navarro | Roger Pavlik | Roger Pavlik | Jaime Navarro | Jay Howell | 232 | 266 | -34 |
| 1994-06-01 | vs TEX | 51 | W 8-1 | - | | 15,026 | Cal Eldred | Hector Fajardo | Cal Eldred | Hector Fajardo | | 240 | 267 | -27 |
| 1994-06-03 | @ CAL | 52 | W 4-3 | - | | 21,331 | Ricky Bones | Mark Langston | Ricky Bones | Mark Langston | Mike Fetters | 244 | 270 | -26 |
| 1994-06-04 | @ CAL | 53 | W 7-6 | - | | 23,952 | Bill Wegman | Chuck Finley | Doug Henry | Bob Patterson | Mike Fetters | 251 | 276 | -25 |
| 1994-06-05 | @ CAL | 54 | L 1-3 | - | | 33,581 | Bob Scanlan | Joe Magrane | Joe Magrane | Jaime Navarro | | 252 | 279 | -27 |
| 1994-06-06 | @ OAK | 55 | W 9-6 | - | | 11,503 | Cal Eldred | Todd Van Poppel | Cal Eldred | Todd Van Poppel | Mike Fetters | 261 | 285 | -24 |
| 1994-06-07 | @ OAK | 56 | L 5-6 | - | | 10,614 | Teddy Higuera | Steve Ontiveros | Billy Taylor | Doug Henry | Dennis Eckersley | 266 | 291 | -25 |
| 1994-06-08 | @ OAK | 57 | W 6-1 | - | | 11,398 | Ricky Bones | Bobby Witt | Ricky Bones | Vince Horsman | | 272 | 292 | -20 |
| 1994-06-09 | vs CLE | 58 | W 4-3 | - | | 16,024 | Bill Wegman | Jack Morris | Mike Ignasiak | Paul Shuey | | 276 | 295 | -19 |
| 1994-06-10 | vs CLE | 59 | W 7-6 | - | | 23,795 | Bob Scanlan | Charles Nagy | Mike Fetters | Jose Mesa | | 283 | 301 | -18 |
| 1994-06-11 | vs CLE | 60 | L 2-5 | - | | 22,222 | Cal Eldred | Jason Grimsley | Jason Grimsley | Cal Eldred | | 285 | 306 | -21 |
| 1994-06-12 | vs CLE | 61 | L 6-12 | - | | 21,786 | Teddy Higuera | Dennis Martinez | Dennis Martinez | Teddy Higuera | Eric Plunk | 291 | 318 | -27 |
| 1994-06-14 | vs DET | 62 | L 8-10 | - | | 21,137 | Ricky Bones | Bill Gullickson | Greg Gohr | Graeme Lloyd | | 299 | 328 | -29 |
| 1994-06-15 | vs DET | 63 | W 11-7 | - | | 15,743 | Bill Wegman | Mike Moore | Bill Wegman | Mike Moore | | 310 | 335 | -25 |
| 1994-06-16 | vs DET | 64 | W 5-4 | - | | 15,603 | Bob Scanlan | Tim Belcher | Graeme Lloyd | Buddy Groom | | 315 | 339 | -24 |
| 1994-06-17 | @ NYA | 65 | W 8-1 | - | | 24,350 | Cal Eldred | Scott Kamieniecki | Cal Eldred | Scott Kamieniecki | | 323 | 340 | -17 |
| 1994-06-18 | @ NYA | 66 | L 2-4 | - | | 35,601 | Mike Ignasiak | Melido Perez | Melido Perez | Jesse Orosco | Bob Wickman | 325 | 344 | -19 |
| 1994-06-19 | @ NYA | 67 | W 10-7 | - | | 31,328 | Ricky Bones | Terry Mulholland | Ricky Bones | Xavier Hernandez | | 335 | 351 | -16 |
| 1994-06-20 | @ BAL | 68 | W 6-5 | - | | 47,262 | Bill Wegman | Jamie Moyer | Bill Wegman | Jamie Moyer | Graeme Lloyd | 341 | 356 | -15 |
| 1994-06-21 | @ BAL | 69 | L 1-6 | - | | 46,599 | Bob Scanlan | Mike Mussina | Mike Mussina | Bob Scanlan | | 342 | 362 | -20 |
| 1994-06-22 | @ BAL | 70 | W 9-2 | - | | 47,186 | Cal Eldred | Ben McDonald | Cal Eldred | Ben McDonald | | 351 | 364 | -13 |
| 1994-06-24 | vs BOS | 71 | L 3-4 | - | | 18,914 | Ricky Bones | Roger Clemens | Greg Harris | Mike Fetters | Ken Ryan | 354 | 368 | -14 |
| 1994-06-25 | vs BOS | 72 | L 8-10 | - | | 35,234 | Bill Wegman | Joe Hesketh | Ken Ryan | Doug Henry | | 362 | 378 | -16 |
| 1994-06-26 | vs BOS | 73 | W 5-4 | - | | 29,414 | Bob Scanlan | Tim VanEgmond | Jaime Navarro | Tim VanEgmond | Mike Fetters | 367 | 382 | -15 |
| 1994-06-27 | vs TOR | 74 | W 5-1 | - | | 15,746 | Cal Eldred | Al Leiter | Cal Eldred | Al Leiter | | 372 | 383 | -11 |
| 1994-06-28 | vs TOR | 75 | W 6-4 | - | | 18,905 | Angel Miranda | Dave Stewart | Jose Mercedes | Dave Stewart | Mike Fetters | 378 | 387 | -9 |
| 1994-06-29 | vs TOR | 76 | L 0-5 | - | | 20,576 | Ricky Bones | Pat Hentgen | Pat Hentgen | Ricky Bones | | 378 | 392 | -14 |
| 1994-06-30 | vs TOR | 77 | W 9-2 | - | | 27,231 | Bill Wegman | Juan Guzman | Bill Wegman | Juan Guzman | | 387 | 394 | -7 |
| 1994-07-01 | @ CHA | 78 | L 0-8 | - | | 26,628 | Bob Scanlan | Jack McDowell | Jack McDowell | Bob Scanlan | | 387 | 402 | -15 |
| 1994-07-02 | @ CHA | 79 | L 0-5 | - | | 41,014 | Cal Eldred | Alex Fernandez | Alex Fernandez | Cal Eldred | | 387 | 407 | -20 |
| 1994-07-03 | @ CHA | 80 | W 9-2 | - | | 33,921 | Angel Miranda | Wilson Alvarez | Angel Miranda | Wilson Alvarez | | 396 | 409 | -13 |
| 1994-07-04 | @ CHA | 81 | L 2-3 | - | | 32,808 | Ricky Bones | Jason Bere | Roberto Hernandez | Ricky Bones | | 398 | 412 | -14 |
| 1994-07-05 | @ KCA | 82 | L 5-10 | - | | 18,239 | Bill Wegman | Mark Gubicza | Rusty Meacham | Bill Wegman | Billy Brewer | 403 | 422 | -19 |
| 1994-07-06 | @ KCA | 83 | W 4-3 | - | | 18,213 | Bob Scanlan | Kevin Appier | Bob Scanlan | Rusty Meacham | Mike Fetters | 407 | 425 | -18 |
| 1994-07-07 | @ KCA | 84 | L 3-8 | - | | 23,247 | Cal Eldred | Tom Gordon | Tom Gordon | Cal Eldred | | 410 | 433 | -23 |
| 1994-07-08 | vs CHA | 85 | L 5-9 | - | | 27,421 | Angel Miranda | Jason Bere | Jason Bere | Angel Miranda | Kirk McCaskill | 415 | 442 | -27 |
| 1994-07-09 | vs CHA | 86 | L 7-11 | - | | 48,508 | Ricky Bones | Scott Sanderson | Scott Sanderson | Ricky Bones | | 422 | 453 | -31 |
| 1994-07-10 | vs CHA | 87 | L 2-7 | - | | 37,073 | Bill Wegman | Jack McDowell | Jack McDowell | Bill Wegman | | 424 | 460 | -36 |
| 1994-07-14 | @ MIN | 88 | W 6-4 | - | | 24,672 | Cal Eldred | Kevin Tapani | Mike Ignasiak | Carl Willis | Mike Fetters | 430 | 464 | -34 |
| 1994-07-15 | @ MIN | 89 | W 8-7 | - | | 24,899 | Ricky Bones | Scott Erickson | Ricky Bones | Scott Erickson | Mike Fetters | 438 | 471 | -33 |
| 1994-07-16 | @ MIN | 90 | L 2-5 | - | | 30,659 | Bill Wegman | Jim Deshaies | Jim Deshaies | Bill Wegman | Rick Aguilera | 440 | 476 | -36 |
| 1994-07-17 | @ MIN | 91 | W 5-3 | - | | 33,529 | Bob Scanlan | Carlos Pulido | Bob Scanlan | Carlos Pulido | Mike Fetters | 445 | 479 | -34 |
| 1994-07-18 | vs KCA | 92 | L 0-2 | - | | 14,040 | Angel Miranda | Chris Haney | Chris Haney | Angel Miranda | Jeff Montgomery | 445 | 481 | -36 |
| 1994-07-19 | vs KCA | 93 | W 4-3 | - | | 14,829 | Cal Eldred | Kevin Appier | Jose Mercedes | Hipolito Pichardo | | 449 | 484 | -35 |
| 1994-07-20 | vs KCA | 94 | W 11-1 | - | | 20,085 | Ricky Bones | Tom Gordon | Ricky Bones | Tom Gordon | | 460 | 485 | -25 |
| 1994-07-21 | vs MIN | 95 | W 7-3 | - | | 21,782 | Bill Wegman | Jim Deshaies | Bill Wegman | Jim Deshaies | | 467 | 488 | -21 |
| 1994-07-22 | vs MIN | 96 | L 5-6 | - | | 23,190 | Bob Scanlan | Eddie Guardado | Rick Aguilera | Jaime Navarro | | 472 | 494 | -22 |
| 1994-07-23 | vs MIN | 97 | L 1-5 | - | | 37,438 | Angel Miranda | Pat Mahomes | Dave Stevens | Angel Miranda | | 473 | 499 | -26 |
| 1994-07-24 | vs MIN | 98 | L 6-10 | - | | 40,195 | Cal Eldred | Kevin Tapani | Carl Willis | Cal Eldred | Erik Schullstrom | 479 | 509 | -30 |
| 1994-07-26 | @ TOR | 99 | W 7-5 | - | | 49,098 | Ricky Bones | Juan Guzman | Ricky Bones | Juan Guzman | Mike Fetters | 486 | 514 | -28 |
| 1994-07-27 | @ TOR | 100 | W 5-0 | - | | 47,172 | Bill Wegman | Pat Hentgen | Bill Wegman | Pat Hentgen | | 491 | 514 | -23 |
| 1994-07-28 | @ TOR | 101 | W 5-4 | - | | 47,061 | Bob Scanlan | Dave Stewart | Jesse Orosco | Danny Cox | Mike Fetters | 496 | 518 | -22 |
| 1994-07-29 | @ BOS | 102 | L 2-7 | - | | 33,528 | Angel Miranda | Tim VanEgmond | Tim VanEgmond | Angel Miranda | | 498 | 525 | -27 |
| 1994-07-30 | @ BOS | 103 | W 5-1 | - | | 33,081 | Cal Eldred | Roger Clemens | Cal Eldred | Roger Clemens | Mike Fetters | 503 | 526 | -23 |
| 1994-07-31 | @ BOS | 104 | W 5-2 | - | | 32,220 | Ricky Bones | Chris Nabholz | Jaime Navarro | Chris Nabholz | Mike Fetters | 508 | 528 | -20 |
| 1994-08-01 | vs NYA | 105 | L 3-8 | - | | 18,361 | Bill Wegman | Melido Perez | Melido Perez | Bill Wegman | | 511 | 536 | -25 |
| 1994-08-02 | vs NYA | 106 | L 1-7 | - | | 23,532 | Bob Scanlan | Scott Kamieniecki | Scott Kamieniecki | Jaime Navarro | | 512 | 543 | -31 |
| 1994-08-03 | vs NYA | 107 | L 1-2 | - | | 25,050 | Angel Miranda | Sterling Hitchcock | Sterling Hitchcock | Angel Miranda | | 513 | 545 | -32 |
| 1994-08-04 | vs BAL | 108 | W 5-3 | - | | 30,150 | Cal Eldred | Mark Williamson | Cal Eldred | Mark Williamson | Mike Fetters | 518 | 548 | -30 |
| 1994-08-05 | vs BAL | 109 | L 0-4 | - | | 23,174 | Ricky Bones | Ben McDonald | Ben McDonald | Ricky Bones | | 518 | 552 | -34 |
| 1994-08-06 | vs BAL | 110 | L 0-5 | - | | 29,077 | Jaime Navarro | Arthur Rhodes | Arthur Rhodes | Jaime Navarro | | 518 | 557 | -39 |
| 1994-08-07 | vs BAL | 111 | L 3-6 | - | | 29,223 | Bob Scanlan | Mike Mussina | Mike Mussina | Bob Scanlan | | 521 | 563 | -42 |
| 1994-08-08 | @ DET | 112 | W 12-4 | - | | 30,803 | Angel Miranda | Tim Belcher | Angel Miranda | Tim Belcher | | 533 | 567 | -34 |
| 1994-08-09 | @ DET | 113 | L 4-10 | - | | 15,874 | Cal Eldred | Sean Bergman | Sean Bergman | Cal Eldred | | 537 | 577 | -40 |
| 1994-08-10 | @ DET | 114 | L 0-4 | - | | 17,705 | Ricky Bones | David Wells | David Wells | Ricky Bones | | 537 | 581 | -44 |
| 1994-08-11 | @ DET | 115 | W 10-5 | - | | 18,857 | Bill Wegman | Mike Moore | Jesse Orosco | Storm Davis | | 547 | 586 | -39 |