| 1993-04-06 | @ SEA | 1 | L 1-8 | 0-1 | 7 | 56,120 | Jack Morris | Randy Johnson | Randy Johnson | Jack Morris | | 1 | 8 | -7 |
| 1993-04-07 | @ SEA | 2 | W 2-0 | 1-1 | 5 | 27,837 | Al Leiter | Chris Bosio | Al Leiter | Chris Bosio | Duane Ward | 3 | 8 | -5 |
| 1993-04-09 | vs CLE | 3 | W 13-10 | 2-1 | 3 | 50,533 | Juan Guzman | Jose Mesa | Mark Eichhorn | Ted Power | Duane Ward | 16 | 18 | -2 |
| 1993-04-10 | vs CLE | 4 | W 5-4 | 3-1 | 2 | 50,492 | Todd Stottlemyre | Charles Nagy | Todd Stottlemyre | Charles Nagy | Duane Ward | 21 | 22 | -1 |
| 1993-04-11 | vs CLE | 5 | L 6-10 | 3-2 | 2 | 47,194 | Jack Morris | Mark Clark | Mark Clark | Jack Morris | Derek Lilliquist | 27 | 32 | -5 |
| 1993-04-13 | vs SEA | 6 | W 6-5 | 4-2 | 2 | 42,230 | Al Leiter | Chris Bosio | Danny Cox | Tim Leary | Duane Ward | 33 | 37 | -4 |
| 1993-04-14 | vs SEA | 7 | L 9-10 | 4-3 | 3 | 43,054 | Juan Guzman | Erik Hanson | Rich DeLucia | Pat Hentgen | Norm Charlton | 42 | 47 | -5 |
| 1993-04-15 | vs SEA | 8 | W 3-1 | 5-3 | 2 | 46,272 | Todd Stottlemyre | John Cummings | Todd Stottlemyre | John Cummings | Duane Ward | 45 | 48 | -3 |
| 1993-04-16 | @ CLE | 9 | L 1-13 | 5-4 | 4 | 17,428 | Jack Morris | Charles Nagy | Charles Nagy | Jack Morris | | 46 | 61 | -15 |
| 1993-04-17 | @ CLE | 10 | W 8-1 | 6-4 | 3 | 21,755 | Pat Hentgen | Mark Clark | Pat Hentgen | Mark Clark | | 54 | 62 | -8 |
| 1993-04-18 | @ CLE | 11 | L 5-6 | 6-5 | 3 | 24,368 | Al Leiter | Jeff Mutis | Jeff Mutis | Al Leiter | Derek Lilliquist | 59 | 68 | -9 |
| 1993-04-19 | @ CLE | 12 | W 7-1 | 7-5 | 3 | 11,750 | Juan Guzman | Mike Bielecki | Juan Guzman | Mike Bielecki | | 66 | 69 | -3 |
| 1993-04-20 | @ KCA | 13 | L 2-8 | 7-6 | 3 | 14,985 | Todd Stottlemyre | Kevin Appier | Kevin Appier | Todd Stottlemyre | | 68 | 77 | -9 |
| 1993-04-21 | @ KCA | 14 | L 5-6 | 7-7 | 4 | 15,693 | Jack Morris | Mark Gubicza | Jeff Montgomery | Mike Timlin | | 73 | 83 | -10 |
| 1993-04-22 | @ KCA | 15 | W 6-3 | 8-7 | 4 | 19,369 | Pat Hentgen | David Cone | Pat Hentgen | David Cone | | 79 | 86 | -7 |
| 1993-04-23 | vs CHA | 16 | L 4-5 | 8-8 | 4 | 50,494 | Al Leiter | Kirk McCaskill | Kirk McCaskill | Al Leiter | Roberto Hernandez | 83 | 91 | -8 |
| 1993-04-24 | vs CHA | 17 | W 10-4 | 9-8 | 4 | 50,518 | Juan Guzman | Rod Bolton | Juan Guzman | Rod Bolton | | 93 | 95 | -2 |
| 1993-04-25 | vs CHA | 18 | W 1-0 | 10-8 | 4 | 50,430 | Todd Stottlemyre | Alex Fernandez | Todd Stottlemyre | Alex Fernandez | Duane Ward | 94 | 95 | -1 |
| 1993-04-26 | vs TEX | 19 | W 8-6 | 11-8 | 3 | 47,368 | Jack Morris | Craig Lefferts | Jack Morris | Craig Lefferts | Duane Ward | 102 | 101 | 1 |
| 1993-04-27 | vs TEX | 20 | W 4-3 | 12-8 | 2 | 49,021 | Pat Hentgen | Robb Nen | Pat Hentgen | Robb Nen | Duane Ward | 106 | 104 | 2 |
| 1993-04-28 | vs KCA | 21 | L 3-5 | 12-9 | 3 | 49,073 | Scott Brow | Mark Gardner | Mark Gardner | Scott Brow | Jeff Montgomery | 109 | 109 | 0 |
| 1993-04-29 | vs KCA | 22 | W 8-0 | 13-9 | 2 | 49,114 | Juan Guzman | Hipolito Pichardo | Juan Guzman | Hipolito Pichardo | | 117 | 109 | 8 |
| 1993-04-30 | @ CHA | 23 | L 2-10 | 13-10 | 4 | 29,497 | Todd Stottlemyre | Alex Fernandez | Alex Fernandez | Todd Stottlemyre | | 119 | 119 | 0 |
| 1993-05-01 | @ CHA | 24 | L 2-8 | 13-11 | 4 | 35,378 | Jack Morris | Wilson Alvarez | Wilson Alvarez | Jack Morris | | 121 | 127 | -6 |
| 1993-05-02 | @ CHA | 25 | W 6-1 | 14-11 | 4 | 25,715 | Pat Hentgen | Jack McDowell | Pat Hentgen | Jack McDowell | Danny Cox | 127 | 128 | -1 |
| 1993-05-04 | @ TEX | 26 | L 2-3 | 14-12 | 4 | 20,354 | Juan Guzman | Charlie Leibrandt | Brian Bohanon | Duane Ward | Tom Henke | 129 | 131 | -2 |
| 1993-05-05 | @ TEX | 27 | L 1-7 | 14-13 | 4 | 16,159 | Todd Stottlemyre | Kenny Rogers | Kenny Rogers | Todd Stottlemyre | | 130 | 138 | -8 |
| 1993-05-06 | vs BAL | 28 | W 10-8 | 15-13 | 4 | 50,505 | Scott Brow | Ben McDonald | Danny Cox | Ben McDonald | Duane Ward | 140 | 146 | -6 |
| 1993-05-07 | vs BAL | 29 | W 3-2 | 16-13 | 3 | 50,498 | Pat Hentgen | Fernando Valenzuela | Mark Eichhorn | Todd Frohwirth | | 143 | 148 | -5 |
| 1993-05-08 | vs BAL | 30 | L 3-6 | 16-14 | 4 | 50,507 | Doug Linton | Rick Sutcliffe | Rick Sutcliffe | Doug Linton | Todd Frohwirth | 146 | 154 | -8 |
| 1993-05-09 | vs BAL | 31 | L 3-4 | 16-15 | 4 | 50,473 | Juan Guzman | Arthur Rhodes | Mark Williamson | Duane Ward | Gregg Olson | 149 | 158 | -9 |
| 1993-05-11 | vs DET | 32 | L 7-12 | 16-16 | 4 | 50,493 | Todd Stottlemyre | Bill Gullickson | Bill Gullickson | Todd Stottlemyre | | 156 | 170 | -14 |
| 1993-05-12 | vs DET | 33 | L 8-13 | 16-17 | 4 | 50,488 | Pat Hentgen | Mike Moore | Bill Krueger | Pat Hentgen | Mike Henneman | 164 | 183 | -19 |
| 1993-05-13 | vs DET | 34 | W 6-5 | 17-17 | 4 | 50,507 | Dave Stewart | Mark Leiter | Tony Castillo | Bob Macdonald | | 170 | 188 | -18 |
| 1993-05-14 | @ NYA | 35 | W 8-6 | 18-17 | 4 | 27,733 | Juan Guzman | Bob Wickman | Duane Ward | Rich Monteleone | | 178 | 194 | -16 |
| 1993-05-15 | @ NYA | 36 | L 3-4 | 18-18 | 4 | 31,372 | Al Leiter | Melido Perez | Melido Perez | Al Leiter | Steve Farr | 181 | 198 | -17 |
| 1993-05-16 | @ NYA | 37 | W 12-6 | 19-18 | 4 | 31,583 | Todd Stottlemyre | Mike Witt | Todd Stottlemyre | Mike Witt | | 193 | 204 | -11 |
| 1993-05-17 | @ BOS | 38 | W 9-3 | 20-18 | 4 | 30,057 | Pat Hentgen | Roger Clemens | Pat Hentgen | Roger Clemens | | 202 | 207 | -5 |
| 1993-05-19 | @ BOS | 39 | L 5-10 | 20-19 | 4 | 27,465 | Dave Stewart | Danny Darwin | Danny Darwin | Dave Stewart | | 207 | 217 | -10 |
| 1993-05-20 | @ BOS | 40 | W 4-3 | 21-19 | 4 | 18,219 | Juan Guzman | Frank Viola | Danny Cox | Paul Quantrill | Duane Ward | 211 | 220 | -9 |
| 1993-05-21 | vs MIN | 41 | W 11-2 | 22-19 | 4 | 50,480 | Jack Morris | Jim Deshaies | Jack Morris | Jim Deshaies | | 222 | 222 | 0 |
| 1993-05-22 | vs MIN | 42 | W 7-0 | 23-19 | 3 | 50,510 | Todd Stottlemyre | Kevin Tapani | Danny Cox | Kevin Tapani | | 229 | 222 | 7 |
| 1993-05-23 | vs MIN | 43 | W 2-1 | 24-19 | 3 | 50,499 | Pat Hentgen | Scott Erickson | Pat Hentgen | Scott Erickson | Duane Ward | 231 | 223 | 8 |
| 1993-05-24 | vs MIL | 44 | W 4-1 | 25-19 | 2 | 50,494 | Dave Stewart | Mike Boddicker | Dave Stewart | Mike Boddicker | Duane Ward | 235 | 224 | 11 |
| 1993-05-25 | vs MIL | 45 | W 4-2 | 26-19 | 2 | 50,504 | Juan Guzman | Bill Wegman | Juan Guzman | Bill Wegman | Duane Ward | 239 | 226 | 13 |
| 1993-05-26 | vs MIL | 46 | L 1-8 | 26-20 | 2 | 50,483 | Jack Morris | Jaime Navarro | Jaime Navarro | Jack Morris | | 240 | 234 | 6 |
| 1993-05-27 | vs MIL | 47 | L 3-9 | 26-21 | 2 | 50,487 | Al Leiter | Ricky Bones | Ricky Bones | Al Leiter | | 243 | 243 | 0 |
| 1993-05-28 | @ OAK | 48 | L 2-3 | 26-22 | 3 | 30,351 | Pat Hentgen | Bobby Witt | Bobby Witt | Danny Cox | Rick Honeycutt | 245 | 246 | -1 |
| 1993-05-29 | @ OAK | 49 | W 5-3 | 27-22 | 3 | 30,467 | Dave Stewart | Bob Welch | Dave Stewart | Bob Welch | Duane Ward | 250 | 249 | 1 |
| 1993-05-30 | @ OAK | 50 | W 13-11 | 28-22 | 3 | 28,167 | Juan Guzman | Storm Davis | Danny Cox | Mike Mohler | Duane Ward | 263 | 260 | 3 |
| 1993-05-31 | @ CAL | 51 | W 10-5 | 29-22 | 3 | 30,620 | Jack Morris | John Farrell | Jack Morris | John Farrell | | 273 | 265 | 8 |
| 1993-06-01 | @ CAL | 52 | W 8-0 | 30-22 | 2 | 18,198 | Al Leiter | Scott Sanderson | Al Leiter | Scott Sanderson | | 281 | 265 | 16 |
| 1993-06-02 | @ CAL | 53 | W 7-6 | 31-22 | 2 | 24,360 | Pat Hentgen | Julio Valera | Pat Hentgen | Julio Valera | Duane Ward | 288 | 271 | 17 |
| 1993-06-04 | vs OAK | 54 | W 4-3 | 32-22 | 2 | 50,507 | Dave Stewart | Bob Welch | Woody Williams | Rich Gossage | | 292 | 274 | 18 |
| 1993-06-05 | vs OAK | 55 | W 9-5 | 33-22 | 2 | 50,514 | Juan Guzman | Shawn Hillegas | Juan Guzman | Shawn Hillegas | | 301 | 279 | 22 |
| 1993-06-06 | vs OAK | 56 | L 3-10 | 33-23 | 2 | 50,505 | Jack Morris | Ron Darling | Ron Darling | Jack Morris | | 304 | 289 | 15 |
| 1993-06-07 | vs CAL | 57 | W 4-2 | 34-23 | 2 | 49,177 | Al Leiter | Scott Sanderson | Al Leiter | Scott Sanderson | Duane Ward | 308 | 291 | 17 |
| 1993-06-08 | vs CAL | 58 | W 14-6 | 35-23 | 2 | 49,112 | Pat Hentgen | Julio Valera | Woody Williams | Julio Valera | | 322 | 297 | 25 |
| 1993-06-09 | vs CAL | 59 | L 4-6 | 35-24 | 2 | 50,503 | Dave Stewart | Mark Langston | Mark Langston | Dave Stewart | Steve Frey | 326 | 303 | 23 |
| 1993-06-10 | @ DET | 60 | L 3-5 | 35-25 | 2 | 27,551 | Juan Guzman | John Doherty | John Doherty | Juan Guzman | Bob Macdonald | 329 | 308 | 21 |
| 1993-06-11 | @ DET | 61 | L 1-6 | 35-26 | 2 | 39,654 | Jack Morris | Bill Gullickson | Bill Gullickson | Jack Morris | | 330 | 314 | 16 |
| 1993-06-12 | @ DET | 62 | L 1-12 | 35-27 | 2 | 47,086 | Al Leiter | Mike Moore | Mike Moore | Al Leiter | | 331 | 326 | 5 |
| 1993-06-13 | @ DET | 63 | W 13-4 | 36-27 | 2 | 44,032 | Pat Hentgen | Mark Leiter | Pat Hentgen | Mark Leiter | | 344 | 330 | 14 |
| 1993-06-14 | @ MIN | 64 | L 3-4 | 36-28 | 3 | 27,887 | Dave Stewart | Willie Banks | Larry Casian | Danny Cox | Carl Willis | 347 | 334 | 13 |
| 1993-06-15 | @ MIN | 65 | W 6-3 | 37-28 | 3 | 31,759 | Juan Guzman | Kevin Tapani | Juan Guzman | Kevin Tapani | Duane Ward | 353 | 337 | 16 |
| 1993-06-16 | @ MIN | 66 | W 4-0 | 38-28 | 2 | 30,326 | Jack Morris | Scott Erickson | Jack Morris | Scott Erickson | | 357 | 337 | 20 |
| 1993-06-17 | vs BOS | 67 | W 7-0 | 39-28 | 2 | 50,528 | Al Leiter | Paul Quantrill | Al Leiter | Paul Quantrill | | 364 | 337 | 27 |
| 1993-06-18 | vs BOS | 68 | W 11-2 | 40-28 | 2 | 50,509 | Pat Hentgen | Roger Clemens | Pat Hentgen | Roger Clemens | | 375 | 339 | 36 |
| 1993-06-19 | vs BOS | 69 | W 9-4 | 41-28 | 2 | 50,510 | Dave Stewart | Danny Darwin | Dave Stewart | Danny Darwin | | 384 | 343 | 41 |
| 1993-06-20 | vs BOS | 70 | W 3-2 | 42-28 | 2 | 50,520 | Juan Guzman | Frank Viola | Mike Timlin | Jeff Russell | | 387 | 345 | 42 |
| 1993-06-22 | vs NYA | 71 | W 5-4 | 43-28 | 2 | 50,513 | Jack Morris | Melido Perez | Woody Williams | Steve Howe | Duane Ward | 392 | 349 | 43 |
| 1993-06-23 | vs NYA | 72 | L 3-4 | 43-29 | 2 | 50,520 | Todd Stottlemyre | Jimmy Key | Jimmy Key | Todd Stottlemyre | Steve Farr | 395 | 353 | 42 |
| 1993-06-24 | vs NYA | 73 | W 7-2 | 44-29 | 2 | 50,516 | Pat Hentgen | Scott Kamieniecki | Pat Hentgen | Scott Kamieniecki | | 402 | 355 | 47 |
| 1993-06-25 | @ MIL | 74 | L 5-6 | 44-30 | 2 | 39,308 | Dave Stewart | Jaime Navarro | Mike Fetters | Danny Cox | | 407 | 361 | 46 |
| 1993-06-26 | @ MIL | 75 | W 3-2 | 45-30 | 1 | 45,173 | Juan Guzman | Cal Eldred | Juan Guzman | Cal Eldred | Duane Ward | 410 | 363 | 47 |
| 1993-06-27 | @ MIL | 76 | W 5-4 | 46-30 | 1 | 45,580 | Jack Morris | Bill Wegman | Jack Morris | Bill Wegman | Duane Ward | 415 | 367 | 48 |
| 1993-06-28 | @ BAL | 77 | W 7-2 | 47-30 | 1 | 46,606 | Todd Stottlemyre | Rick Sutcliffe | Todd Stottlemyre | Rick Sutcliffe | Al Leiter | 422 | 369 | 53 |
| 1993-06-29 | @ BAL | 78 | W 2-1 | 48-30 | 1 | 46,408 | Pat Hentgen | Ben McDonald | Pat Hentgen | Ben McDonald | Duane Ward | 424 | 370 | 54 |
| 1993-06-30 | @ BAL | 79 | L 0-6 | 48-31 | 1 | 46,409 | Dave Stewart | Fernando Valenzuela | Fernando Valenzuela | Dave Stewart | | 424 | 376 | 48 |
| 1993-07-02 | @ KCA | 80 | L 2-3 | 48-32 | 1 | 23,832 | Juan Guzman | Hipolito Pichardo | Mark Gubicza | Danny Cox | | 426 | 379 | 47 |
| 1993-07-03 | @ KCA | 81 | L 2-3 | 48-33 | 1 | 28,060 | Jack Morris | David Cone | David Cone | Jack Morris | Jeff Montgomery | 428 | 382 | 46 |
| 1993-07-04 | @ KCA | 82 | L 1-3 | 48-34 | 1 | 40,329 | Todd Stottlemyre | Chris Haney | Chris Haney | Todd Stottlemyre | Jeff Montgomery | 429 | 385 | 44 |
| 1993-07-05 | vs CHA | 83 | L 3-4 | 48-35 | 1 | 50,508 | Pat Hentgen | Wilson Alvarez | Wilson Alvarez | Pat Hentgen | Roberto Hernandez | 432 | 389 | 43 |
| 1993-07-06 | vs CHA | 84 | W 5-1 | 49-35 | 1 | 50,505 | Dave Stewart | Jack McDowell | Dave Stewart | Jack McDowell | | 437 | 390 | 47 |
| 1993-07-07 | vs CHA | 85 | L 2-5 | 49-36 | 1 | 50,517 | Juan Guzman | Alex Fernandez | Alex Fernandez | Juan Guzman | Roberto Hernandez | 439 | 395 | 44 |
| 1993-07-08 | vs TEX | 86 | L 1-6 | 49-37 | 1 | 50,525 | Jack Morris | Kenny Rogers | Kenny Rogers | Jack Morris | | 440 | 401 | 39 |
| 1993-07-09 | vs TEX | 87 | L 2-4 | 49-38 | 1 | 50,506 | Todd Stottlemyre | Roger Pavlik | Roger Pavlik | Todd Stottlemyre | Tom Henke | 442 | 405 | 37 |
| 1993-07-10 | vs TEX | 88 | L 7-10 | 49-39 | 1 | 50,508 | Pat Hentgen | Brian Bohanon | Craig Lefferts | Pat Hentgen | Tom Henke | 449 | 415 | 34 |
| 1993-07-11 | vs TEX | 89 | L 6-11 | 49-40 | 1 | 50,516 | Dave Stewart | Charlie Leibrandt | Charlie Leibrandt | Dave Stewart | | 455 | 426 | 29 |
| 1993-07-15 | vs KCA | 90 | W 7-2 | 50-40 | 1 | 50,503 | Juan Guzman | David Cone | Al Leiter | Enrique Burgos | | 462 | 428 | 34 |
| 1993-07-16 | vs KCA | 91 | L 3-7 | 50-41 | 1 | 50,531 | Jack Morris | Chris Haney | Chris Haney | Jack Morris | Jeff Montgomery | 465 | 435 | 30 |
| 1993-07-17 | vs KCA | 92 | L 4-5 | 50-42 | 2 | 50,512 | Todd Stottlemyre | Kevin Appier | Mark Gubicza | Danny Cox | Jeff Montgomery | 469 | 440 | 29 |
| 1993-07-18 | vs KCA | 93 | W 4-3 | 51-42 | 2 | 50,524 | Pat Hentgen | Hipolito Pichardo | Pat Hentgen | Hipolito Pichardo | | 473 | 443 | 30 |
| 1993-07-19 | @ CHA | 94 | W 15-7 | 52-42 | 2 | 40,127 | Dave Stewart | Rod Bolton | Dave Stewart | Rod Bolton | | 488 | 450 | 38 |
| 1993-07-20 | @ CHA | 95 | L 1-2 | 52-43 | 3 | 30,454 | Juan Guzman | Alex Fernandez | Alex Fernandez | Juan Guzman | | 489 | 452 | 37 |
| 1993-07-21 | @ CHA | 96 | W 4-1 | 53-43 | 1 | 30,900 | Jack Morris | Wilson Alvarez | Al Leiter | Wilson Alvarez | Duane Ward | 493 | 453 | 40 |
| 1993-07-22 | @ TEX | 97 | W 8-7 | 54-43 | 1 | 38,198 | Todd Stottlemyre | Kenny Rogers | Mike Timlin | Cris Carpenter | Duane Ward | 501 | 460 | 41 |
| 1993-07-23 | @ TEX | 98 | L 5-6 | 54-44 | 3 | 38,124 | Pat Hentgen | Roger Pavlik | Craig Lefferts | Pat Hentgen | Tom Henke | 506 | 466 | 40 |
| 1993-07-24 | @ TEX | 99 | W 5-1 | 55-44 | 3 | 38,457 | Dave Stewart | Charlie Leibrandt | Dave Stewart | Charlie Leibrandt | Duane Ward | 511 | 467 | 44 |
| 1993-07-25 | @ TEX | 100 | W 9-7 | 56-44 | 3 | 40,277 | Juan Guzman | Nolan Ryan | Mike Timlin | Tom Henke | Duane Ward | 520 | 474 | 46 |
| 1993-07-27 | vs BAL | 101 | W 6-5 | 57-44 | 1 | 50,513 | Jack Morris | Rick Sutcliffe | Duane Ward | Jim Poole | | 526 | 479 | 47 |
| 1993-07-28 | vs BAL | 102 | W 5-4 | 58-44 | 1 | 50,523 | Todd Stottlemyre | Fernando Valenzuela | Tony Castillo | Mark Williamson | | 531 | 483 | 48 |
| 1993-07-29 | vs DET | 103 | W 7-4 | 59-44 | 1 | 50,528 | Pat Hentgen | Sean Bergman | Tony Castillo | Tom Bolton | Duane Ward | 538 | 487 | 51 |
| 1993-07-30 | vs DET | 104 | L 5-8 | 59-45 | 2 | 50,511 | Dave Stewart | Mike Moore | Mike Moore | Dave Stewart | Mike Henneman | 543 | 495 | 48 |
| 1993-07-31 | vs DET | 105 | W 3-1 | 60-45 | 2 | 50,532 | Juan Guzman | David Wells | Mike Timlin | David Wells | Duane Ward | 546 | 496 | 50 |
| 1993-08-01 | vs DET | 106 | W 2-1 | 61-45 | 1 | 50,522 | Jack Morris | Bill Gullickson | Jack Morris | Mike Henneman | | 548 | 497 | 51 |
| 1993-08-02 | @ NYA | 107 | W 4-0 | 62-45 | 1 | 43,304 | Todd Stottlemyre | Jim Abbott | Todd Stottlemyre | Jim Abbott | Danny Cox | 552 | 497 | 55 |
| 1993-08-03 | @ NYA | 108 | W 8-6 | 63-45 | 1 | 48,031 | Pat Hentgen | Mark Hutton | Pat Hentgen | Bobby Munoz | Al Leiter | 560 | 503 | 57 |
| 1993-08-04 | @ NYA | 109 | L 2-6 | 63-46 | 1 | 48,250 | Dave Stewart | Scott Kamieniecki | Scott Kamieniecki | Dave Stewart | | 562 | 509 | 53 |
| 1993-08-05 | @ NYA | 110 | L 4-5 | 63-47 | 1 | 52,493 | Juan Guzman | Jimmy Key | Jimmy Key | Al Leiter | | 566 | 514 | 52 |
| 1993-08-06 | vs MIL | 111 | W 11-10 | 64-47 | 1 | 50,517 | Jack Morris | Jaime Navarro | Al Leiter | Doug Henry | | 577 | 524 | 53 |
| 1993-08-07 | vs MIL | 112 | L 1-7 | 64-48 | 1 | 50,506 | Todd Stottlemyre | Angel Miranda | Angel Miranda | Todd Stottlemyre | | 578 | 531 | 47 |
| 1993-08-08 | vs MIL | 113 | L 2-5 | 64-49 | 1 | 50,510 | Pat Hentgen | Ricky Bones | Ricky Bones | Pat Hentgen | | 580 | 536 | 44 |
| 1993-08-10 | vs MIN | 114 | W 6-3 | 65-49 | 1 | 50,530 | Dave Stewart | Scott Erickson | Dave Stewart | Scott Erickson | Duane Ward | 586 | 539 | 47 |
| 1993-08-11 | vs MIN | 115 | W 4-2 | 66-49 | 1 | 50,525 | Juan Guzman | Jim Deshaies | Juan Guzman | Jim Deshaies | Duane Ward | 590 | 541 | 49 |
| 1993-08-12 | vs MIN | 116 | L 2-9 | 66-50 | 1 | 50,527 | Jack Morris | Kevin Tapani | Kevin Tapani | Jack Morris | | 592 | 550 | 42 |
| 1993-08-13 | @ BOS | 117 | L 3-5 | 66-51 | 2 | 34,276 | Todd Stottlemyre | Danny Darwin | Danny Darwin | Todd Stottlemyre | Jeff Russell | 595 | 555 | 40 |
| 1993-08-14 | @ BOS | 118 | W 5-2 | 67-51 | 2 | 33,924 | Pat Hentgen | John Dopson | Pat Hentgen | John Dopson | Duane Ward | 600 | 557 | 43 |
| 1993-08-15 | @ BOS | 119 | W 9-1 | 68-51 | 2 | 33,380 | Dave Stewart | Roger Clemens | Dave Stewart | Roger Clemens | | 609 | 558 | 51 |
| 1993-08-16 | @ CLE | 120 | W 4-1 | 69-51 | 1 | 25,546 | Juan Guzman | Bob Ojeda | Juan Guzman | Bob Ojeda | Duane Ward | 613 | 559 | 54 |
| 1993-08-17 | @ CLE | 121 | W 6-4 | 70-51 | 1 | 40,253 | Jack Morris | Tom Kramer | Jack Morris | Tom Kramer | Duane Ward | 619 | 563 | 56 |
| 1993-08-18 | @ CLE | 122 | W 7-6 | 71-51 | 1 | 24,003 | Todd Stottlemyre | Albie Lopez | Danny Cox | Derek Lilliquist | Duane Ward | 626 | 569 | 57 |
| 1993-08-20 | vs SEA | 123 | L 1-4 | 71-52 | 1 | 50,527 | Pat Hentgen | Randy Johnson | Randy Johnson | Pat Hentgen | | 627 | 573 | 54 |
| 1993-08-21 | vs SEA | 124 | L 2-5 | 71-53 | 2 | 50,519 | Dave Stewart | Dave Fleming | Dave Fleming | Dave Stewart | Ted Power | 629 | 578 | 51 |
| 1993-08-22 | vs SEA | 125 | W 12-7 | 72-53 | 1 | 50,511 | Juan Guzman | Chris Bosio | Juan Guzman | Steve Ontiveros | | 641 | 585 | 56 |
| 1993-08-23 | vs CLE | 126 | L 8-9 | 72-54 | 2 | 50,518 | Jack Morris | Albie Lopez | Jeremy Hernandez | Mark Eichhorn | Jerry DiPoto | 649 | 594 | 55 |
| 1993-08-24 | vs CLE | 127 | W 8-6 | 73-54 | 1 | 50,511 | Todd Stottlemyre | Julian Tavarez | Todd Stottlemyre | Julian Tavarez | Duane Ward | 657 | 600 | 57 |
| 1993-08-25 | vs CLE | 128 | W 10-7 | 74-54 | 1 | 50,525 | Pat Hentgen | Jose Mesa | Pat Hentgen | Jose Mesa | Duane Ward | 667 | 607 | 60 |
| 1993-08-26 | @ SEA | 129 | L 3-6 | 74-55 | 2 | 28,463 | Dave Stewart | Randy Johnson | Randy Johnson | Dave Stewart | Ted Power | 670 | 613 | 57 |
| 1993-08-27 | @ SEA | 130 | L 6-7 | 74-56 | 2 | 31,771 | Juan Guzman | Dave Fleming | Jeff Nelson | Woody Williams | Erik Plantenberg | 676 | 620 | 56 |
| 1993-08-28 | @ SEA | 131 | L 1-2 | 74-57 | 2 | 56,076 | Jack Morris | Chris Bosio | Chris Bosio | Danny Cox | Ted Power | 677 | 622 | 55 |
| 1993-08-29 | @ SEA | 132 | W 6-2 | 75-57 | 2 | 34,593 | Todd Stottlemyre | Erik Hanson | Todd Stottlemyre | Erik Hanson | | 683 | 624 | 59 |
| 1993-08-30 | @ OAK | 133 | W 4-2 | 76-57 | 1 | 24,371 | Pat Hentgen | Ron Darling | Pat Hentgen | Ron Darling | Duane Ward | 687 | 626 | 61 |
| 1993-08-31 | @ OAK | 134 | W 3-2 | 77-57 | 1 | 21,334 | Dave Stewart | Bobby Witt | Danny Cox | Dennis Eckersley | Duane Ward | 690 | 628 | 62 |
| 1993-09-01 | @ OAK | 135 | W 8-3 | 78-57 | 1 | 24,251 | Juan Guzman | Mike Mohler | Juan Guzman | Mike Mohler | | 698 | 631 | 67 |
| 1993-09-03 | @ CAL | 136 | L 1-4 | 78-58 | 1 | 23,834 | Jack Morris | Mark Langston | Mark Langston | Jack Morris | Joe Grahe | 699 | 635 | 64 |
| 1993-09-04 | @ CAL | 137 | L 2-4 | 78-59 | 1 | 21,530 | Todd Stottlemyre | Joe Magrane | Joe Magrane | Todd Stottlemyre | Steve Frey | 701 | 639 | 62 |
| 1993-09-05 | @ CAL | 138 | L 1-5 | 78-60 | 2 | 19,653 | Pat Hentgen | Phil Leftwich | Phil Leftwich | Pat Hentgen | | 702 | 644 | 58 |
| 1993-09-07 | vs OAK | 139 | L 7-11 | 78-61 | 1 | 50,515 | Dave Stewart | Ron Darling | Rick Honeycutt | Tony Castillo | | 709 | 655 | 54 |
| 1993-09-08 | vs OAK | 140 | L 1-2 | 78-62 | 1 | 50,329 | Juan Guzman | Bobby Witt | Bobby Witt | Duane Ward | Dennis Eckersley | 710 | 657 | 53 |
| 1993-09-09 | vs OAK | 141 | L 4-7 | 78-63 | 2 | 50,518 | Jack Morris | Steve Karsay | Roger Smithberg | Tony Castillo | Dennis Eckersley | 714 | 664 | 50 |
| 1993-09-10 | vs CAL | 142 | W 10-4 | 79-63 | 1 | 50,522 | Todd Stottlemyre | Phil Leftwich | Todd Stottlemyre | Phil Leftwich | | 724 | 668 | 56 |
| 1993-09-11 | vs CAL | 143 | W 9-5 | 80-63 | 1 | 50,529 | Pat Hentgen | Hilly Hathaway | Pat Hentgen | Hilly Hathaway | | 733 | 673 | 60 |
| 1993-09-12 | vs CAL | 144 | W 4-1 | 81-63 | 1 | 50,523 | Dave Stewart | Chuck Finley | Dave Stewart | Chuck Finley | Duane Ward | 737 | 674 | 63 |
| 1993-09-14 | @ DET | 145 | W 9-5 | 82-63 | 1 | 23,674 | Juan Guzman | Bill Gullickson | Juan Guzman | Storm Davis | | 746 | 679 | 67 |
| 1993-09-15 | @ DET | 146 | W 14-8 | 83-63 | 1 | 24,526 | Todd Stottlemyre | Mike Moore | Todd Stottlemyre | Mike Moore | Duane Ward | 760 | 687 | 73 |
| 1993-09-17 | @ MIN | 147 | W 4-2 | 84-63 | 1 | 24,113 | Pat Hentgen | Kevin Tapani | Pat Hentgen | Kevin Tapani | Duane Ward | 764 | 689 | 75 |
| 1993-09-18 | @ MIN | 148 | W 5-1 | 85-63 | 1 | 26,415 | Dave Stewart | Scott Erickson | Dave Stewart | Scott Erickson | Mike Timlin | 769 | 690 | 79 |
| 1993-09-19 | @ MIN | 149 | W 10-0 | 86-63 | 1 | 23,775 | Juan Guzman | Mike Trombley | Juan Guzman | Mike Trombley | | 779 | 690 | 89 |
| 1993-09-21 | vs BOS | 150 | W 5-0 | 87-63 | 1 | 50,524 | Todd Stottlemyre | Roger Clemens | Todd Stottlemyre | Roger Clemens | | 784 | 690 | 94 |
| 1993-09-22 | vs BOS | 151 | L 5-7 | 87-64 | 1 | 50,532 | Pat Hentgen | Aaron Sele | Ken Ryan | Mike Timlin | | 789 | 697 | 92 |
| 1993-09-23 | vs BOS | 152 | W 5-1 | 88-64 | 1 | 50,528 | Dave Stewart | Nate Minchey | Dave Stewart | Nate Minchey | | 794 | 698 | 96 |
| 1993-09-24 | vs NYA | 153 | W 7-3 | 89-64 | 1 | 50,517 | Juan Guzman | Jimmy Key | Juan Guzman | Jimmy Key | | 801 | 701 | 100 |
| 1993-09-25 | vs NYA | 154 | W 3-1 | 90-64 | 1 | 50,527 | Al Leiter | Frank Tanana | Al Leiter | Frank Tanana | Duane Ward | 804 | 702 | 102 |
| 1993-09-26 | vs NYA | 155 | L 3-7 | 90-65 | 1 | 50,518 | Todd Stottlemyre | Jim Abbott | Jim Abbott | Todd Stottlemyre | | 807 | 709 | 98 |
| 1993-09-27 | @ MIL | 156 | W 2-0 | 91-65 | 1 | 14,931 | Pat Hentgen | Cal Eldred | Pat Hentgen | Cal Eldred | Duane Ward | 809 | 709 | 100 |
| 1993-09-28 | @ MIL | 157 | W 6-4 | 92-65 | 1 | 13,182 | Dave Stewart | Teddy Higuera | Dave Stewart | Matt Maysey | Duane Ward | 815 | 713 | 102 |
| 1993-09-29 | @ MIL | 158 | W 9-6 | 93-65 | 1 | 13,508 | Juan Guzman | Angel Miranda | Mark Eichhorn | Jesse Orosco | Duane Ward | 824 | 719 | 105 |
| 1993-09-30 | @ BAL | 159 | W 6-2 | 94-65 | 1 | 45,653 | Al Leiter | Arthur Rhodes | Al Leiter | Arthur Rhodes | | 830 | 721 | 109 |
| 1993-10-01 | @ BAL | 160 | L 2-7 | 94-66 | 1 | 45,881 | Todd Stottlemyre | Fernando Valenzuela | Fernando Valenzuela | Todd Stottlemyre | | 832 | 728 | 104 |
| 1993-10-02 | @ BAL | 161 | L 4-8 | 94-67 | 1 | 46,094 | Pat Hentgen | Rick Sutcliffe | Rick Sutcliffe | Pat Hentgen | Alan Mills | 836 | 736 | 100 |
| 1993-10-03 | @ BAL | 162 | W 11-6 | 95-67 | 1 | 45,913 | Scott Brow | Ben McDonald | Scott Brow | Ben McDonald | | 847 | 742 | 105 |