| 1992-04-06 | @ BAL | 1 | L 0-2 | 0-1 | 4 | 44,568 | Charles Nagy | Rick Sutcliffe | Rick Sutcliffe | Charles Nagy | | 0 | 2 | -2 |
| 1992-04-08 | @ BAL | 2 | W 4-0 | 1-1 | 4 | 42,870 | Dave Otto | Bob Milacki | Dave Otto | Bob Milacki | | 4 | 2 | 2 |
| 1992-04-09 | @ BAL | 3 | L 0-2 | 1-2 | 4 | 42,646 | Jack Armstrong | Ben McDonald | Ben McDonald | Jack Armstrong | | 4 | 4 | 0 |
| 1992-04-11 | vs BOS | 4 | L 5-7 | 1-3 | 6 | 65,813 | Dennis Cook | Joe Hesketh | Mike Gardiner | Eric Bell | | 9 | 11 | -2 |
| 1992-04-12 | vs BOS | 5 | W 2-1 | 2-4 | 5 | 0 | Charles Nagy | Matt Young | Charles Nagy | Matt Young | Derek Lilliquist | 11 | 12 | -1 |
| 1992-04-12 | vs BOS | 6 | L 0-3 | 2-4 | 5 | 20,480 | Scott Scudder | Roger Clemens | Roger Clemens | Scott Scudder | | 11 | 15 | -4 |
| 1992-04-13 | vs DET | 7 | L 5-7 | 2-5 | 6 | 5,615 | Dave Otto | Frank Tanana | Mark Leiter | Rod Nichols | Mike Henneman | 16 | 22 | -6 |
| 1992-04-14 | vs DET | 8 | W 8-7 | 3-5 | 5 | 4,083 | Jack Armstrong | Walt Terrell | Ted Power | Les Lancaster | Steve Olin | 24 | 29 | -5 |
| 1992-04-15 | vs DET | 9 | L 1-8 | 3-6 | 6 | 5,280 | Eric Bell | Eric King | Eric King | Eric Bell | | 25 | 37 | -12 |
| 1992-04-16 | vs DET | 10 | L 4-13 | 3-7 | 6 | 6,434 | Dennis Cook | Bill Gullickson | Bill Gullickson | Dennis Cook | | 29 | 50 | -21 |
| 1992-04-17 | @ NYA | 11 | W 11-1 | 4-7 | 6 | 14,335 | Charles Nagy | Scott Sanderson | Charles Nagy | Scott Sanderson | | 40 | 51 | -11 |
| 1992-04-18 | @ NYA | 12 | L 0-14 | 4-8 | 6 | 18,052 | Dave Otto | Greg Cadaret | Greg Cadaret | Dave Otto | | 40 | 65 | -25 |
| 1992-04-19 | @ NYA | 13 | L 3-5 | 4-9 | 6 | 17,175 | Jack Armstrong | Jeff Johnson | Jeff Johnson | Jack Armstrong | Steve Howe | 43 | 70 | -27 |
| 1992-04-20 | @ NYA | 14 | W 3-1 | 5-9 | 6 | 19,417 | Scott Scudder | Melido Perez | Scott Scudder | Melido Perez | Steve Olin | 46 | 71 | -25 |
| 1992-04-21 | @ TOR | 15 | L 1-2 | 5-10 | 6 | 40,191 | Dennis Cook | Jack Morris | Jack Morris | Dennis Cook | | 47 | 73 | -26 |
| 1992-04-22 | @ TOR | 16 | W 7-2 | 6-10 | 6 | 43,292 | Charles Nagy | Dave Stieb | Charles Nagy | Dave Stieb | Ted Power | 54 | 75 | -21 |
| 1992-04-23 | @ TOR | 17 | L 8-13 | 6-11 | 6 | 42,401 | Dave Otto | Todd Stottlemyre | Todd Stottlemyre | Dave Otto | | 62 | 88 | -26 |
| 1992-04-24 | vs MIL | 18 | L 0-5 | 6-12 | 6 | 9,042 | Jack Armstrong | Dan Plesac | Dan Plesac | Jack Armstrong | | 62 | 93 | -31 |
| 1992-04-26 | vs MIL | 19 | L 4-9 | 7-13 | 6 | 0 | Scott Scudder | Chris Bosio | Chris Bosio | Scott Scudder | | 66 | 102 | -36 |
| 1992-04-26 | vs MIL | 20 | W 3-1 | 7-13 | 6 | 7,150 | Dennis Cook | Jaime Navarro | Dennis Cook | Jaime Navarro | Ted Power | 69 | 103 | -34 |
| 1992-04-28 | vs OAK | 21 | L 1-3 | 7-14 | 7 | 5,028 | Charles Nagy | Mike Moore | Mike Moore | Steve Olin | Dennis Eckersley | 70 | 106 | -36 |
| 1992-04-29 | vs OAK | 22 | W 5-2 | 8-14 | 6 | 5,055 | Dave Otto | Ron Darling | Dave Otto | Ron Darling | Steve Olin | 75 | 108 | -33 |
| 1992-04-30 | vs CAL | 23 | L 5-8 | 8-15 | 6 | 4,675 | Jeff Shaw | Joe Grahe | Joe Grahe | Jeff Shaw | Bryan Harvey | 80 | 116 | -36 |
| 1992-05-01 | vs CAL | 24 | L 5-7 | 8-16 | 6 | 9,367 | Scott Scudder | Mark Langston | Mark Langston | Scott Scudder | Bryan Harvey | 85 | 123 | -38 |
| 1992-05-02 | vs CAL | 25 | W 3-2 | 9-16 | 6 | 6,544 | Dennis Cook | Julio Valera | Derek Lilliquist | Mark Eichhorn | Steve Olin | 88 | 125 | -37 |
| 1992-05-03 | vs CAL | 26 | L 3-6 | 9-17 | 7 | 8,797 | Charles Nagy | Chuck Finley | Scott Bailes | Derek Lilliquist | Bryan Harvey | 91 | 131 | -40 |
| 1992-05-04 | vs KCA | 27 | L 6-11 | 9-18 | 7 | 3,930 | Dave Otto | Tom Gordon | Rusty Meacham | Rod Nichols | | 97 | 142 | -45 |
| 1992-05-05 | vs KCA | 28 | W 8-6 | 10-18 | 7 | 5,021 | Jack Armstrong | Mike Magnante | Jack Armstrong | Mike Magnante | Steve Olin | 105 | 148 | -43 |
| 1992-05-06 | @ TEX | 29 | W 7-2 | 11-18 | 7 | 17,125 | Scott Scudder | Bobby Witt | Scott Scudder | Bobby Witt | Kevin Wickander | 112 | 150 | -38 |
| 1992-05-07 | @ TEX | 30 | W 8-7 | 12-18 | 6 | 19,573 | Dennis Cook | Roger Pavlik | Rod Nichols | Mike Campbell | Steve Olin | 120 | 157 | -37 |
| 1992-05-08 | @ MIN | 31 | L 4-7 | 12-19 | 7 | 25,083 | Charles Nagy | Scott Erickson | Scott Erickson | Charles Nagy | Rick Aguilera | 124 | 164 | -40 |
| 1992-05-09 | @ MIN | 32 | L 5-10 | 12-20 | 7 | 26,330 | Dave Otto | John Smiley | John Smiley | Dave Otto | | 129 | 174 | -45 |
| 1992-05-10 | @ MIN | 33 | L 6-10 | 12-21 | 7 | 18,962 | Jack Armstrong | Pat Mahomes | Mark Guthrie | Jack Armstrong | Rick Aguilera | 135 | 184 | -49 |
| 1992-05-12 | @ KCA | 34 | L 0-3 | 12-22 | 7 | 18,480 | Scott Scudder | Mark Gubicza | Mark Gubicza | Scott Scudder | | 135 | 187 | -52 |
| 1992-05-13 | @ KCA | 35 | L 3-5 | 12-23 | 7 | 17,252 | Dennis Cook | Kevin Appier | Kevin Appier | Dennis Cook | Jeff Montgomery | 138 | 192 | -54 |
| 1992-05-15 | vs MIN | 36 | W 5-0 | 13-23 | 7 | 25,695 | Charles Nagy | Scott Erickson | Charles Nagy | Scott Erickson | | 143 | 192 | -49 |
| 1992-05-16 | vs MIN | 37 | L 6-8 | 13-24 | 7 | 19,556 | Jack Armstrong | John Smiley | John Smiley | Jack Armstrong | Rick Aguilera | 149 | 200 | -51 |
| 1992-05-17 | vs MIN | 38 | L 5-9 | 13-25 | 7 | 9,672 | Dennis Cook | Kevin Tapani | Kevin Tapani | Dennis Cook | Rick Aguilera | 154 | 209 | -55 |
| 1992-05-18 | vs TEX | 39 | L 2-3 | 13-26 | 7 | 4,438 | Scott Scudder | Kevin Brown | Kevin Brown | Derek Lilliquist | Kenny Rogers | 156 | 212 | -56 |
| 1992-05-19 | vs TEX | 40 | L 7-8 | 13-27 | 7 | 7,348 | Jack Armstrong | Roger Pavlik | Lance McCullers | Steve Olin | Jeff Russell | 163 | 220 | -57 |
| 1992-05-20 | vs TEX | 41 | L 0-1 | 13-28 | 7 | 6,687 | Charles Nagy | Jose Guzman | Jose Guzman | Charles Nagy | Jeff Russell | 163 | 221 | -58 |
| 1992-05-22 | @ SEA | 42 | L 1-2 | 13-29 | 7 | 14,936 | Scott Scudder | Randy Johnson | Randy Johnson | Scott Scudder | Mike Schooler | 164 | 223 | -59 |
| 1992-05-23 | @ SEA | 43 | W 5-4 | 14-29 | 7 | 15,272 | Denis Boucher | Erik Hanson | Derek Lilliquist | Erik Hanson | Steve Olin | 169 | 227 | -58 |
| 1992-05-24 | @ SEA | 44 | L 4-5 | 14-30 | 7 | 14,089 | Jack Armstrong | Clay Parker | Calvin Jones | Steve Olin | | 173 | 232 | -59 |
| 1992-05-25 | @ OAK | 45 | W 10-6 | 15-30 | 7 | 41,050 | Charles Nagy | Joe Slusarski | Charles Nagy | Joe Slusarski | Ted Power | 183 | 238 | -55 |
| 1992-05-26 | @ OAK | 46 | W 1-0 | 16-30 | 7 | 18,842 | Dave Otto | Bob Welch | Dave Otto | Bob Welch | Steve Olin | 184 | 238 | -54 |
| 1992-05-27 | @ OAK | 47 | W 4-2 | 17-30 | 7 | 24,679 | Scott Scudder | Dave Stewart | Scott Scudder | Dave Stewart | Steve Olin | 188 | 240 | -52 |
| 1992-05-29 | @ CAL | 48 | W 14-2 | 18-30 | 7 | 22,322 | Denis Boucher | Chuck Finley | Denis Boucher | Chuck Finley | | 202 | 242 | -40 |
| 1992-05-30 | @ CAL | 49 | L 1-3 | 18-31 | 7 | 37,322 | Jack Armstrong | Bert Blyleven | Bert Blyleven | Jack Armstrong | Bryan Harvey | 203 | 245 | -42 |
| 1992-05-31 | @ CAL | 50 | W 4-3 | 19-31 | 7 | 40,167 | Charles Nagy | Jim Abbott | Charles Nagy | Jim Abbott | Steve Olin | 207 | 248 | -41 |
| 1992-06-02 | vs SEA | 51 | W 4-3 | 20-31 | 7 | 7,265 | Dave Otto | Erik Hanson | Dave Otto | Erik Hanson | Steve Olin | 211 | 251 | -40 |
| 1992-06-03 | vs SEA | 52 | W 8-3 | 21-31 | 7 | 7,536 | Scott Scudder | Clay Parker | Scott Scudder | Clay Parker | | 219 | 254 | -35 |
| 1992-06-04 | vs SEA | 53 | L 3-10 | 21-32 | 7 | 5,022 | Denis Boucher | Dave Fleming | Dave Fleming | Denis Boucher | | 222 | 264 | -42 |
| 1992-06-06 | @ BOS | 54 | L 1-5 | 22-33 | 7 | 0 | Jack Armstrong | Roger Clemens | Roger Clemens | Jack Armstrong | | 223 | 269 | -46 |
| 1992-06-06 | @ BOS | 55 | W 3-1 | 22-33 | 7 | 32,937 | Charles Nagy | Frank Viola | Charles Nagy | Frank Viola | Steve Olin | 226 | 270 | -44 |
| 1992-06-07 | @ BOS | 56 | L 0-4 | 22-34 | 7 | 33,202 | Dave Otto | Joe Hesketh | Joe Hesketh | Dave Otto | Danny Darwin | 226 | 274 | -48 |
| 1992-06-08 | @ DET | 57 | L 2-9 | 22-35 | 7 | 11,667 | Scott Scudder | Mark Leiter | Mark Leiter | Scott Scudder | Kurt Knudsen | 228 | 283 | -55 |
| 1992-06-09 | @ DET | 58 | W 6-1 | 23-35 | 7 | 11,840 | Denis Boucher | Frank Tanana | Denis Boucher | Frank Tanana | | 234 | 284 | -50 |
| 1992-06-10 | @ DET | 59 | W 4-2 | 24-35 | 7 | 11,767 | Jack Armstrong | Kevin Ritz | Steve Olin | Mike Munoz | | 238 | 286 | -48 |
| 1992-06-12 | vs NYA | 60 | W 3-0 | 25-35 | 6 | 30,193 | Charles Nagy | Scott Kamieniecki | Charles Nagy | Scott Kamieniecki | | 241 | 286 | -45 |
| 1992-06-13 | vs NYA | 61 | L 1-4 | 25-36 | 7 | 19,249 | Dave Otto | Melido Perez | Melido Perez | Dave Otto | Steve Farr | 242 | 290 | -48 |
| 1992-06-14 | vs NYA | 62 | L 3-4 | 25-37 | 7 | 35,171 | Scott Scudder | Jeff Johnson | Rich Monteleone | Ted Power | Steve Farr | 245 | 294 | -49 |
| 1992-06-15 | vs BAL | 63 | L 5-6 | 25-38 | 7 | 7,277 | Denis Boucher | Rick Sutcliffe | Storm Davis | Dennis Cook | Gregg Olson | 250 | 300 | -50 |
| 1992-06-16 | vs BAL | 64 | W 7-5 | 26-38 | 7 | 11,754 | Jack Armstrong | Ben McDonald | Jack Armstrong | Ben McDonald | Steve Olin | 257 | 305 | -48 |
| 1992-06-17 | vs BAL | 65 | W 3-2 | 27-38 | 7 | 11,334 | Charles Nagy | Mike Mussina | Charles Nagy | Mike Mussina | | 260 | 307 | -47 |
| 1992-06-18 | @ MIL | 66 | L 1-4 | 27-39 | 7 | 12,691 | Dave Otto | Bill Wegman | Bill Wegman | Dave Otto | | 261 | 311 | -50 |
| 1992-06-19 | @ MIL | 67 | W 5-3 | 28-39 | 7 | 19,111 | Scott Scudder | Ricky Bones | Scott Scudder | Ricky Bones | Steve Olin | 266 | 314 | -48 |
| 1992-06-20 | @ MIL | 68 | L 1-4 | 28-40 | 7 | 25,337 | Denis Boucher | Chris Bosio | Chris Bosio | Denis Boucher | Doug Henry | 267 | 318 | -51 |
| 1992-06-21 | @ MIL | 69 | L 2-4 | 28-41 | 7 | 23,609 | Jack Armstrong | Ron Robinson | Dan Plesac | Jack Armstrong | Doug Henry | 269 | 322 | -53 |
| 1992-06-22 | @ CHA | 70 | L 1-7 | 28-42 | 7 | 32,967 | Charles Nagy | Charlie Hough | Charlie Hough | Charles Nagy | | 270 | 329 | -59 |
| 1992-06-23 | @ CHA | 71 | L 1-7 | 28-43 | 7 | 36,972 | Dave Otto | Jack McDowell | Jack McDowell | Dave Otto | | 271 | 336 | -65 |
| 1992-06-24 | @ CHA | 72 | L 3-4 | 28-44 | 7 | 30,575 | Scott Scudder | Greg Hibbard | Roberto Hernandez | Ted Power | | 274 | 340 | -66 |
| 1992-06-26 | vs TOR | 73 | L 1-6 | 28-45 | 7 | 16,299 | Jack Armstrong | Juan Guzman | Juan Guzman | Jack Armstrong | | 275 | 346 | -71 |
| 1992-06-27 | vs TOR | 74 | W 6-4 | 29-45 | 7 | 40,560 | Charles Nagy | Jimmy Key | Eric Plunk | Duane Ward | | 281 | 350 | -69 |
| 1992-06-28 | vs TOR | 75 | W 7-6 | 30-45 | 7 | 23,560 | Dennis Cook | Jack Morris | Steve Olin | Duane Ward | Eric Plunk | 288 | 356 | -68 |
| 1992-06-29 | vs CHA | 76 | L 6-9 | 30-46 | 7 | 8,331 | Scott Scudder | Jack McDowell | Jack McDowell | Scott Scudder | Bobby Thigpen | 294 | 365 | -71 |
| 1992-06-30 | vs CHA | 77 | W 5-4 | 31-46 | 7 | 16,956 | Denis Boucher | Greg Hibbard | Derek Lilliquist | Terry Leach | | 299 | 369 | -70 |
| 1992-07-01 | vs CHA | 78 | L 5-8 | 31-47 | 7 | 11,302 | Jack Armstrong | Kirk McCaskill | Kirk McCaskill | Jack Armstrong | Bobby Thigpen | 304 | 377 | -73 |
| 1992-07-03 | vs OAK | 79 | W 8-1 | 32-47 | 7 | 44,849 | Charles Nagy | Ron Darling | Charles Nagy | Ron Darling | | 312 | 378 | -66 |
| 1992-07-04 | vs OAK | 80 | W 8-1 | 33-47 | 7 | 18,510 | Scott Scudder | Kelly Downs | Scott Scudder | Kelly Downs | Ted Power | 320 | 379 | -59 |
| 1992-07-05 | vs OAK | 81 | L 2-5 | 33-48 | 7 | 30,598 | Jack Armstrong | Bob Welch | Bob Welch | Jack Armstrong | Dennis Eckersley | 322 | 384 | -62 |
| 1992-07-06 | vs OAK | 82 | L 4-13 | 33-49 | 7 | 12,057 | Jeff Mutis | Mike Moore | Mike Moore | Jeff Mutis | | 326 | 397 | -71 |
| 1992-07-07 | vs CAL | 83 | W 3-1 | 34-49 | 7 | 9,796 | Dennis Cook | Chuck Finley | Dennis Cook | Chuck Finley | Steve Olin | 329 | 398 | -69 |
| 1992-07-08 | vs CAL | 84 | W 8-4 | 35-49 | 7 | 7,195 | Charles Nagy | Mark Langston | Charles Nagy | Mark Langston | | 337 | 402 | -65 |
| 1992-07-09 | @ TEX | 85 | L 4-14 | 35-50 | 7 | 35,560 | Scott Scudder | Nolan Ryan | Nolan Ryan | Scott Scudder | | 341 | 416 | -75 |
| 1992-07-10 | @ TEX | 86 | L 5-6 | 35-51 | 7 | 25,916 | Jack Armstrong | Brian Bohanon | Brian Bohanon | Jack Armstrong | Jeff Russell | 346 | 422 | -76 |
| 1992-07-11 | @ TEX | 87 | L 1-5 | 35-52 | 7 | 33,046 | Jeff Mutis | Kevin Brown | Kevin Brown | Jeff Mutis | | 347 | 427 | -80 |
| 1992-07-12 | @ TEX | 88 | W 6-3 | 36-52 | 7 | 25,116 | Dennis Cook | Todd Burns | Steve Olin | Kenny Rogers | Eric Plunk | 353 | 430 | -77 |
| 1992-07-16 | @ KCA | 89 | L 2-3 | 36-53 | 7 | 25,080 | Jose Mesa | Hipolito Pichardo | Hipolito Pichardo | Jose Mesa | Jeff Montgomery | 355 | 433 | -78 |
| 1992-07-17 | @ KCA | 90 | L 3-4 | 36-54 | 7 | 28,033 | Charles Nagy | Rick Reed | Jeff Montgomery | Eric Plunk | | 358 | 437 | -79 |
| 1992-07-18 | @ KCA | 91 | L 1-4 | 36-55 | 7 | 29,000 | Jack Armstrong | Kevin Appier | Kevin Appier | Jack Armstrong | Rusty Meacham | 359 | 441 | -82 |
| 1992-07-19 | @ KCA | 92 | W 4-3 | 37-55 | 7 | 21,637 | Scott Scudder | Luis Aquino | Derek Lilliquist | Steve Shifflett | Steve Olin | 363 | 444 | -81 |
| 1992-07-20 | @ MIN | 93 | W 5-1 | 38-55 | 7 | 26,190 | Dennis Cook | Willie Banks | Dennis Cook | Willie Banks | Steve Olin | 368 | 445 | -77 |
| 1992-07-21 | @ MIN | 94 | W 5-2 | 39-55 | 7 | 28,992 | Jose Mesa | Kevin Tapani | Jose Mesa | Kevin Tapani | Steve Olin | 373 | 447 | -74 |
| 1992-07-22 | @ MIN | 95 | L 1-2 | 39-56 | 7 | 40,394 | Charles Nagy | John Smiley | John Smiley | Charles Nagy | | 374 | 449 | -75 |
| 1992-07-23 | vs KCA | 96 | W 1-0 | 40-56 | 7 | 8,788 | Rod Nichols | Kevin Appier | Kevin Wickander | Mike Magnante | | 375 | 449 | -74 |
| 1992-07-24 | vs KCA | 97 | L 3-8 | 40-57 | 7 | 10,824 | Scott Scudder | Luis Aquino | Luis Aquino | Scott Scudder | Jeff Montgomery | 378 | 457 | -79 |
| 1992-07-25 | vs KCA | 98 | W 6-5 | 41-57 | 7 | 15,779 | Dennis Cook | Mike Boddicker | Steve Olin | Rusty Meacham | | 384 | 462 | -78 |
| 1992-07-26 | vs KCA | 99 | W 2-1 | 42-57 | 7 | 22,239 | Jose Mesa | Hipolito Pichardo | Steve Olin | Steve Shifflett | | 386 | 463 | -77 |
| 1992-07-27 | vs MIL | 100 | L 0-4 | 42-58 | 7 | 8,538 | Charles Nagy | Jaime Navarro | Jaime Navarro | Charles Nagy | | 386 | 467 | -81 |
| 1992-07-28 | vs MIL | 101 | W 4-2 | 43-58 | 7 | 12,164 | Rod Nichols | Ricky Bones | Rod Nichols | Ricky Bones | Derek Lilliquist | 390 | 469 | -79 |
| 1992-07-29 | vs MIL | 102 | W 4-3 | 44-58 | 7 | 10,836 | Scott Scudder | Cal Eldred | Jack Armstrong | Cal Eldred | Derek Lilliquist | 394 | 472 | -78 |
| 1992-07-31 | vs DET | 103 | L 6-9 | 44-59 | 7 | 53,419 | Dennis Cook | Walt Terrell | John Kiely | Eric Plunk | Mike Henneman | 400 | 481 | -81 |
| 1992-08-01 | vs DET | 104 | W 8-5 | 45-59 | 7 | 21,066 | Jose Mesa | Frank Tanana | Eric Plunk | Les Lancaster | Derek Lilliquist | 408 | 486 | -78 |
| 1992-08-02 | vs DET | 105 | L 4-5 | 45-60 | 7 | 25,733 | Charles Nagy | Bill Gullickson | Bill Gullickson | Charles Nagy | Mike Henneman | 412 | 491 | -79 |
| 1992-08-03 | @ NYA | 106 | W 8-6 | 46-60 | 7 | 15,046 | Rod Nichols | Scott Kamieniecki | Steve Olin | John Habyan | | 420 | 497 | -77 |
| 1992-08-04 | @ NYA | 107 | L 3-4 | 46-61 | 7 | 14,013 | Dave Otto | Curt Young | Curt Young | Dave Otto | Steve Farr | 423 | 501 | -78 |
| 1992-08-05 | @ NYA | 108 | W 4-3 | 47-61 | 7 | 15,634 | Dennis Cook | Shawn Hillegas | Derek Lilliquist | Tim Burke | | 427 | 504 | -77 |
| 1992-08-07 | @ BAL | 109 | W 5-4 | 48-61 | 7 | 45,755 | Jose Mesa | Ben McDonald | Kevin Wickander | Alan Mills | | 432 | 508 | -76 |
| 1992-08-08 | @ BAL | 110 | W 6-0 | 49-61 | 7 | 45,686 | Charles Nagy | Arthur Rhodes | Charles Nagy | Arthur Rhodes | | 438 | 508 | -70 |
| 1992-08-09 | @ BAL | 111 | L 2-3 | 49-62 | 7 | 43,742 | Rod Nichols | Rick Sutcliffe | Storm Davis | Ted Power | | 440 | 511 | -71 |
| 1992-08-10 | vs BOS | 112 | W 8-5 | 50-62 | 7 | 9,225 | Dennis Cook | Danny Darwin | Jack Armstrong | Paul Quantrill | Steve Olin | 448 | 516 | -68 |
| 1992-08-11 | vs BOS | 113 | W 3-1 | 51-62 | 6 | 15,425 | Dave Otto | Frank Viola | Dave Otto | Frank Viola | Derek Lilliquist | 451 | 517 | -66 |
| 1992-08-12 | vs BOS | 114 | W 8-5 | 52-62 | 6 | 11,516 | Jose Mesa | John Dopson | Eric Plunk | Daryl Irvine | Steve Olin | 459 | 522 | -63 |
| 1992-08-13 | vs BOS | 115 | L 2-4 | 52-63 | 7 | 26,797 | Charles Nagy | Roger Clemens | Roger Clemens | Charles Nagy | Jeff Reardon | 461 | 526 | -65 |
| 1992-08-14 | vs TOR | 116 | L 5-9 | 52-64 | 7 | 41,686 | Rod Nichols | David Wells | David Wells | Rod Nichols | | 466 | 535 | -69 |
| 1992-08-16 | vs TOR | 117 | W 4-2 | 53-65 | 7 | 0 | Dennis Cook | Todd Stottlemyre | Dennis Cook | Todd Stottlemyre | Steve Olin | 470 | 537 | -67 |
| 1992-08-16 | vs TOR | 118 | L 2-6 | 53-65 | 7 | 27,997 | Dave Otto | Jack Morris | Jack Morris | Dave Otto | | 472 | 543 | -71 |
| 1992-08-18 | vs MIN | 119 | W 8-1 | 54-65 | 6 | 15,736 | Jose Mesa | Scott Erickson | Jose Mesa | Scott Erickson | Ted Power | 480 | 544 | -64 |
| 1992-08-19 | vs MIN | 120 | W 5-1 | 55-65 | 6 | 11,300 | Charles Nagy | Bill Krueger | Charles Nagy | Bill Krueger | | 485 | 545 | -60 |
| 1992-08-20 | vs MIN | 121 | W 2-1 | 56-65 | 5 | 11,062 | Rod Nichols | Kevin Tapani | Eric Plunk | Kevin Tapani | | 487 | 546 | -59 |
| 1992-08-21 | vs TEX | 122 | W 8-6 | 57-65 | 5 | 35,101 | Dennis Cook | Nolan Ryan | Dennis Cook | Nolan Ryan | Steve Olin | 495 | 552 | -57 |
| 1992-08-22 | vs TEX | 123 | W 6-1 | 58-65 | 4 | 16,799 | Jack Armstrong | Bobby Witt | Jack Armstrong | Bobby Witt | | 501 | 553 | -52 |
| 1992-08-23 | vs TEX | 124 | L 4-14 | 58-66 | 5 | 27,706 | Jose Mesa | Kevin Brown | Kenny Rogers | Steve Olin | | 505 | 567 | -62 |
| 1992-08-25 | @ SEA | 125 | L 0-6 | 58-67 | 5 | 14,015 | Charles Nagy | Dave Fleming | Dave Fleming | Charles Nagy | | 505 | 573 | -68 |
| 1992-08-26 | @ SEA | 126 | W 6-3 | 59-67 | 5 | 12,289 | Rod Nichols | Randy Johnson | Eric Plunk | Russ Swan | Steve Olin | 511 | 576 | -65 |
| 1992-08-27 | @ SEA | 127 | L 2-6 | 59-68 | 6 | 11,891 | Dennis Cook | Brian Fisher | Brian Fisher | Dennis Cook | | 513 | 582 | -69 |
| 1992-08-28 | @ OAK | 128 | L 6-7 | 59-69 | 7 | 30,422 | Jack Armstrong | Mike Moore | Jim Corsi | Jack Armstrong | Dennis Eckersley | 519 | 589 | -70 |
| 1992-08-29 | @ OAK | 129 | L 1-4 | 59-70 | 7 | 35,036 | Jose Mesa | Dave Stewart | Dave Stewart | Jose Mesa | Dennis Eckersley | 520 | 593 | -73 |
| 1992-08-30 | @ OAK | 130 | L 5-7 | 59-71 | 7 | 37,524 | Charles Nagy | Ron Darling | Ron Darling | Charles Nagy | Rick Honeycutt | 525 | 600 | -75 |
| 1992-08-31 | @ CAL | 131 | W 4-3 | 60-71 | 7 | 18,013 | Rod Nichols | Bert Blyleven | Rod Nichols | Bert Blyleven | Eric Plunk | 529 | 603 | -74 |
| 1992-09-01 | @ CAL | 132 | L 6-7 | 60-72 | 7 | 17,586 | Dennis Cook | Tim Fortugno | Chuck Crim | Eric Plunk | Joe Grahe | 535 | 610 | -75 |
| 1992-09-02 | @ CAL | 133 | L 2-3 | 60-73 | 7 | 18,141 | Jack Armstrong | Chuck Finley | Scott Lewis | Derek Lilliquist | | 537 | 613 | -76 |
| 1992-09-04 | vs SEA | 134 | W 7-0 | 61-73 | 7 | 9,933 | Jose Mesa | Dave Fleming | Jose Mesa | Dave Fleming | | 544 | 613 | -69 |
| 1992-09-05 | vs SEA | 135 | W 5-4 | 62-73 | 7 | 11,270 | Charles Nagy | Randy Johnson | Eric Plunk | Russ Swan | | 549 | 617 | -68 |
| 1992-09-06 | vs SEA | 136 | W 12-9 | 63-73 | 7 | 13,483 | Rod Nichols | Brian Fisher | Steve Olin | Mike Schooler | | 561 | 626 | -65 |
| 1992-09-07 | @ MIL | 137 | L 0-2 | 63-74 | 7 | 41,348 | Dennis Cook | Cal Eldred | Cal Eldred | Dennis Cook | Doug Henry | 561 | 628 | -67 |
| 1992-09-08 | @ MIL | 138 | L 3-7 | 63-75 | 7 | 39,650 | Jack Armstrong | Ricky Bones | Ricky Bones | Jack Armstrong | Mike Fetters | 564 | 635 | -71 |
| 1992-09-09 | @ MIL | 139 | W 5-4 | 64-75 | 6 | 47,589 | Jose Mesa | Chris Bosio | Steve Olin | Doug Henry | | 569 | 639 | -70 |
| 1992-09-11 | @ CHA | 140 | W 5-1 | 65-75 | 6 | 30,983 | Charles Nagy | Greg Hibbard | Charles Nagy | Greg Hibbard | | 574 | 640 | -66 |
| 1992-09-12 | @ CHA | 141 | W 5-3 | 66-75 | 5 | 34,768 | Dave Mlicki | Kirk McCaskill | Eric Plunk | Kirk McCaskill | Steve Olin | 579 | 643 | -64 |
| 1992-09-13 | @ CHA | 142 | W 2-1 | 67-75 | 5 | 34,235 | Dennis Cook | Jack McDowell | Eric Plunk | Bobby Thigpen | Steve Olin | 581 | 644 | -63 |
| 1992-09-14 | @ TOR | 143 | W 2-1 | 68-75 | 5 | 50,394 | Jose Mesa | David Cone | Jose Mesa | David Cone | Steve Olin | 583 | 645 | -62 |
| 1992-09-15 | @ TOR | 144 | L 4-5 | 68-76 | 5 | 49,487 | Alan Embree | Juan Guzman | Juan Guzman | Alan Embree | Tom Henke | 587 | 650 | -63 |
| 1992-09-16 | @ TOR | 145 | W 6-3 | 69-76 | 4 | 50,416 | Charles Nagy | Todd Stottlemyre | Charles Nagy | Todd Stottlemyre | Ted Power | 593 | 653 | -60 |
| 1992-09-17 | @ TOR | 146 | L 5-7 | 69-77 | 4 | 50,408 | Scott Scudder | Jack Morris | Duane Ward | Eric Plunk | | 598 | 660 | -62 |
| 1992-09-18 | vs CHA | 147 | L 7-8 | 69-78 | 4 | 25,861 | Dave Mlicki | Kirk McCaskill | Kirk McCaskill | Dave Mlicki | Roberto Hernandez | 605 | 668 | -63 |
| 1992-09-19 | vs CHA | 148 | W 5-4 | 70-78 | 4 | 13,014 | Dennis Cook | Jack McDowell | Eric Plunk | Jack McDowell | Steve Olin | 610 | 672 | -62 |
| 1992-09-20 | vs CHA | 149 | L 8-10 | 70-79 | 4 | 13,457 | Jose Mesa | Wilson Alvarez | Mike Dunne | Jose Mesa | Bobby Thigpen | 618 | 682 | -64 |
| 1992-09-22 | @ BOS | 150 | W 4-2 | 71-79 | 5 | 24,412 | Alan Embree | Roger Clemens | Ted Power | Roger Clemens | Derek Lilliquist | 622 | 684 | -62 |
| 1992-09-23 | @ BOS | 151 | W 7-3 | 72-79 | 4 | 26,415 | Charles Nagy | Scott Taylor | Charles Nagy | Scott Taylor | | 629 | 687 | -58 |
| 1992-09-24 | @ BOS | 152 | L 4-6 | 72-80 | 5 | 28,135 | Scott Scudder | Danny Darwin | Danny Darwin | Scott Scudder | Greg Harris | 633 | 693 | -60 |
| 1992-09-25 | @ DET | 153 | L 5-6 | 72-81 | 6 | 13,624 | Dave Mlicki | Bill Gullickson | Mike Henneman | Steve Olin | | 638 | 699 | -61 |
| 1992-09-26 | @ DET | 154 | W 7-4 | 73-81 | 5 | 16,567 | Dennis Cook | Dave Haas | Jack Armstrong | Kurt Knudsen | Steve Olin | 645 | 703 | -58 |
| 1992-09-27 | @ DET | 155 | L 3-13 | 73-82 | 6 | 14,330 | Jose Mesa | Walt Terrell | Walt Terrell | Jose Mesa | | 648 | 716 | -68 |
| 1992-09-28 | vs NYA | 156 | W 6-4 | 74-82 | 4 | 5,979 | Alan Embree | Sam Militello | Ted Power | Sam Militello | Steve Olin | 654 | 720 | -66 |
| 1992-09-29 | vs NYA | 157 | W 4-3 | 75-82 | 4 | 7,672 | Charles Nagy | Scott Kamieniecki | Charles Nagy | Scott Kamieniecki | Eric Plunk | 658 | 723 | -65 |
| 1992-09-30 | vs NYA | 158 | L 2-4 | 75-83 | 4 | 6,211 | Dave Mlicki | Melido Perez | Melido Perez | Dave Mlicki | Steve Farr | 660 | 727 | -67 |
| 1992-10-01 | vs BAL | 159 | L 2-3 | 75-84 | 4 | 5,076 | Dennis Cook | Mike Mussina | Mike Mussina | Eric Plunk | Gregg Olson | 662 | 730 | -68 |
| 1992-10-02 | vs BAL | 160 | W 8-5 | 76-84 | 4 | 10,367 | Jose Mesa | Craig Lefferts | Rod Nichols | Craig Lefferts | | 670 | 735 | -65 |
| 1992-10-03 | vs BAL | 161 | L 1-7 | 76-85 | 4 | 11,504 | Alan Embree | Arthur Rhodes | Arthur Rhodes | Alan Embree | Mark Williamson | 671 | 742 | -71 |
| 1992-10-04 | vs BAL | 162 | L 3-4 | 76-86 | 4 | 30,187 | Charles Nagy | Ben McDonald | Alan Mills | Eric Plunk | Bob Milacki | 674 | 746 | -72 |