| 1992-04-07 | @ CAL | 1 | W 10-4 | 1-0 | 1 | 32,160 | Jack McDowell | Mark Langston | Jack McDowell | Mark Langston | Wilson Alvarez | 10 | 4 | 6 |
| 1992-04-08 | @ CAL | 2 | W 4-3 | 2-0 | 1 | 21,622 | Greg Hibbard | Jim Abbott | Greg Hibbard | Jim Abbott | Bobby Thigpen | 14 | 7 | 7 |
| 1992-04-09 | @ CAL | 3 | W 7-6 | 3-0 | 1 | 19,926 | Kirk McCaskill | Joe Grahe | Kirk McCaskill | Joe Grahe | Scott Radinsky | 21 | 13 | 8 |
| 1992-04-10 | @ OAK | 4 | L 5-6 | 3-1 | 3 | 38,457 | Alex Fernandez | Joe Slusarski | Joe Slusarski | Alex Fernandez | Dennis Eckersley | 26 | 19 | 7 |
| 1992-04-11 | @ OAK | 5 | L 6-7 | 3-2 | 3 | 36,007 | Charlie Hough | Dave Stewart | Jeff Parrett | Terry Leach | | 32 | 26 | 6 |
| 1992-04-12 | @ OAK | 6 | W 6-4 | 4-2 | 3 | 27,462 | Jack McDowell | John Briscoe | Jack McDowell | Gene Nelson | Bobby Thigpen | 38 | 30 | 8 |
| 1992-04-13 | vs SEA | 7 | W 1-0 | 5-2 | 3 | 42,290 | Greg Hibbard | Russ Swan | Greg Hibbard | Russ Swan | Bobby Thigpen | 39 | 30 | 9 |
| 1992-04-15 | vs SEA | 8 | L 0-6 | 5-3 | 3 | 21,311 | Kirk McCaskill | Dave Fleming | Dave Fleming | Kirk McCaskill | | 39 | 36 | 3 |
| 1992-04-16 | vs SEA | 9 | W 5-4 | 6-3 | 2 | 22,432 | Alex Fernandez | Rich DeLucia | Alex Fernandez | Rich DeLucia | | 44 | 40 | 4 |
| 1992-04-17 | vs MIN | 10 | L 0-7 | 6-4 | 3 | 33,716 | Charlie Hough | Bill Krueger | Bill Krueger | Charlie Hough | | 44 | 47 | -3 |
| 1992-04-18 | vs MIN | 11 | W 4-3 | 7-4 | 2 | 29,680 | Jack McDowell | Scott Erickson | Jack McDowell | Scott Erickson | | 48 | 50 | -2 |
| 1992-04-19 | vs MIN | 12 | W 4-1 | 8-4 | 2 | 24,307 | Greg Hibbard | John Smiley | Greg Hibbard | John Smiley | Bobby Thigpen | 52 | 51 | 1 |
| 1992-04-21 | vs NYA | 13 | L 3-4 | 8-5 | 2 | 23,249 | Kirk McCaskill | Tim Leary | Tim Leary | Kirk McCaskill | Steve Farr | 55 | 55 | 0 |
| 1992-04-22 | vs NYA | 14 | L 3-4 | 8-6 | 2 | 25,226 | Alex Fernandez | Scott Sanderson | Steve Howe | Scott Radinsky | | 58 | 59 | -1 |
| 1992-04-24 | @ DET | 15 | W 9-1 | 9-6 | 2 | 10,404 | Jack McDowell | Walt Terrell | Jack McDowell | Walt Terrell | | 67 | 60 | 7 |
| 1992-04-26 | @ DET | 16 | W 7-6 | 10-6 | 2 | 14,181 | Greg Hibbard | Eric King | Greg Hibbard | Eric King | Bobby Thigpen | 74 | 66 | 8 |
| 1992-04-28 | @ BOS | 17 | L 3-6 | 10-7 | 2 | 27,673 | Kirk McCaskill | Roger Clemens | Roger Clemens | Kirk McCaskill | Jeff Reardon | 77 | 72 | 5 |
| 1992-04-29 | @ BOS | 18 | L 1-6 | 10-8 | 3 | 27,205 | Alex Fernandez | Frank Viola | Frank Viola | Alex Fernandez | Jeff Reardon | 78 | 78 | 0 |
| 1992-04-30 | vs TEX | 19 | W 12-1 | 11-8 | 2 | 24,134 | Jack McDowell | Nolan Ryan | Jack McDowell | Nolan Ryan | | 90 | 79 | 11 |
| 1992-05-01 | vs TEX | 20 | L 4-8 | 11-9 | 3 | 32,213 | Greg Hibbard | Bobby Witt | Bobby Witt | Greg Hibbard | Jeff Russell | 94 | 87 | 7 |
| 1992-05-02 | vs TEX | 21 | L 1-4 | 11-10 | 3 | 29,172 | Charlie Hough | Roger Pavlik | Jeff Robinson | Bobby Thigpen | | 95 | 91 | 4 |
| 1992-05-03 | vs TEX | 22 | W 5-3 | 12-10 | 3 | 30,314 | Kirk McCaskill | Kevin Brown | Scott Radinsky | Kevin Brown | | 100 | 94 | 6 |
| 1992-05-04 | vs MIL | 23 | W 7-0 | 13-10 | 2 | 21,211 | Alex Fernandez | Ricky Bones | Alex Fernandez | Ricky Bones | | 107 | 94 | 13 |
| 1992-05-05 | vs MIL | 24 | W 12-2 | 14-10 | 1 | 22,901 | Jack McDowell | Chris Bosio | Jack McDowell | Chris Bosio | | 119 | 96 | 23 |
| 1992-05-06 | vs BOS | 25 | W 7-5 | 15-10 | 1 | 25,338 | Greg Hibbard | Mike Gardiner | Scott Radinsky | Danny Darwin | Bobby Thigpen | 126 | 101 | 25 |
| 1992-05-07 | vs BOS | 26 | W 7-6 | 16-10 | 1 | 25,582 | Charlie Hough | Matt Young | Donn Pall | Greg Harris | Bobby Thigpen | 133 | 107 | 26 |
| 1992-05-08 | @ BAL | 27 | W 4-3 | 17-10 | 1 | 41,364 | Kirk McCaskill | Mike Mussina | Terry Leach | Gregg Olson | Bobby Thigpen | 137 | 110 | 27 |
| 1992-05-09 | @ BAL | 28 | L 2-5 | 17-11 | 2 | 45,175 | Alex Fernandez | Bob Milacki | Bob Milacki | Alex Fernandez | Gregg Olson | 139 | 115 | 24 |
| 1992-05-10 | @ BAL | 29 | W 5-2 | 18-11 | 2 | 44,609 | Jack McDowell | Jose Mesa | Jack McDowell | Jose Mesa | Bobby Thigpen | 144 | 117 | 27 |
| 1992-05-12 | @ MIL | 30 | L 2-6 | 18-12 | 2 | 12,842 | Greg Hibbard | Jaime Navarro | Jaime Navarro | Greg Hibbard | | 146 | 123 | 23 |
| 1992-05-13 | @ MIL | 31 | W 1-0 | 19-12 | 1 | 20,662 | Kirk McCaskill | Bill Wegman | Kirk McCaskill | Bill Wegman | Bobby Thigpen | 147 | 123 | 24 |
| 1992-05-15 | vs BAL | 32 | L 0-2 | 19-13 | 1 | 38,026 | Alex Fernandez | Mike Mussina | Mike Mussina | Alex Fernandez | Gregg Olson | 147 | 125 | 22 |
| 1992-05-16 | vs BAL | 33 | L 2-7 | 19-14 | 2 | 41,993 | Jack McDowell | Bob Milacki | Bob Milacki | Jack McDowell | | 149 | 132 | 17 |
| 1992-05-17 | vs BAL | 34 | W 14-10 | 20-14 | 1 | 40,903 | Greg Hibbard | Ben McDonald | Donn Pall | Ben McDonald | | 163 | 142 | 21 |
| 1992-05-18 | vs KCA | 35 | L 1-6 | 20-15 | 2 | 25,434 | Kirk McCaskill | Mike Magnante | Mike Magnante | Kirk McCaskill | | 164 | 148 | 16 |
| 1992-05-19 | vs KCA | 36 | W 2-1 | 21-15 | 2 | 26,510 | Charlie Hough | Kevin Appier | Charlie Hough | Kevin Appier | Bobby Thigpen | 166 | 149 | 17 |
| 1992-05-20 | vs KCA | 37 | L 2-7 | 21-16 | 2 | 29,250 | Alex Fernandez | Hipolito Pichardo | Hipolito Pichardo | Alex Fernandez | Mike Boddicker | 168 | 156 | 12 |
| 1992-05-22 | vs TOR | 38 | L 2-6 | 21-17 | 2 | 37,446 | Jack McDowell | Juan Guzman | Juan Guzman | Jack McDowell | Duane Ward | 170 | 162 | 8 |
| 1992-05-23 | vs TOR | 39 | W 5-2 | 22-17 | 2 | 39,293 | Greg Hibbard | Jimmy Key | Greg Hibbard | Jimmy Key | Bobby Thigpen | 175 | 164 | 11 |
| 1992-05-24 | vs TOR | 40 | W 8-1 | 23-17 | 2 | 32,230 | Kirk McCaskill | Jack Morris | Kirk McCaskill | Jack Morris | | 183 | 165 | 18 |
| 1992-05-26 | @ TEX | 41 | L 5-6 | 23-18 | 2 | 20,019 | Charlie Hough | Jose Guzman | Jose Guzman | Charlie Hough | Ed Nunez | 188 | 171 | 17 |
| 1992-05-27 | @ TEX | 42 | L 3-4 | 23-19 | 3 | 25,958 | Alex Fernandez | Nolan Ryan | Floyd Bannister | Donn Pall | | 191 | 175 | 16 |
| 1992-05-28 | @ TEX | 43 | L 2-4 | 23-20 | 4 | 24,251 | Jack McDowell | Bobby Witt | Bobby Witt | Jack McDowell | Jeff Russell | 193 | 179 | 14 |
| 1992-05-29 | @ TOR | 44 | L 0-3 | 23-21 | 4 | 50,408 | Greg Hibbard | Juan Guzman | Duane Ward | Greg Hibbard | Tom Henke | 193 | 182 | 11 |
| 1992-05-30 | @ TOR | 45 | L 1-2 | 23-22 | 4 | 50,391 | Kirk McCaskill | Jimmy Key | David Wells | Donn Pall | | 194 | 184 | 10 |
| 1992-05-31 | @ TOR | 46 | L 2-3 | 23-23 | 4 | 50,393 | Charlie Hough | Jack Morris | Jack Morris | Bobby Thigpen | | 196 | 187 | 9 |
| 1992-06-01 | @ KCA | 47 | W 5-3 | 24-23 | 4 | 25,297 | Alex Fernandez | Mike Boddicker | Alex Fernandez | Mike Boddicker | | 201 | 190 | 11 |
| 1992-06-02 | @ KCA | 48 | L 1-2 | 24-24 | 4 | 18,203 | Jack McDowell | Mark Gubicza | Mark Gubicza | Scott Radinsky | Jeff Montgomery | 202 | 192 | 10 |
| 1992-06-03 | @ KCA | 49 | L 1-3 | 24-25 | 4 | 19,218 | Greg Hibbard | Mike Magnante | Mike Magnante | Greg Hibbard | Jeff Montgomery | 203 | 195 | 8 |
| 1992-06-05 | vs OAK | 50 | L 3-10 | 24-26 | 4 | 37,117 | Kirk McCaskill | Ron Darling | Ron Darling | Kirk McCaskill | | 206 | 205 | 1 |
| 1992-06-06 | vs OAK | 51 | L 4-6 | 24-27 | 4 | 42,483 | Alex Fernandez | Dave Stewart | Dave Stewart | Alex Fernandez | Dennis Eckersley | 210 | 211 | -1 |
| 1992-06-07 | vs OAK | 52 | W 6-1 | 25-27 | 4 | 42,415 | Charlie Hough | Mike Moore | Charlie Hough | Mike Moore | | 216 | 212 | 4 |
| 1992-06-08 | vs CAL | 53 | W 5-1 | 26-27 | 4 | 30,483 | Jack McDowell | Chuck Finley | Jack McDowell | Chuck Finley | Bobby Thigpen | 221 | 213 | 8 |
| 1992-06-09 | vs CAL | 54 | W 4-2 | 27-27 | 4 | 29,906 | Greg Hibbard | Julio Valera | Greg Hibbard | Julio Valera | Scott Radinsky | 225 | 215 | 10 |
| 1992-06-10 | vs CAL | 55 | W 3-2 | 28-27 | 4 | 26,483 | Kirk McCaskill | Jim Abbott | Donn Pall | Steve Frey | | 228 | 217 | 11 |
| 1992-06-11 | vs CAL | 56 | L 0-4 | 28-28 | 4 | 33,058 | Alex Fernandez | Bert Blyleven | Bert Blyleven | Alex Fernandez | Joe Grahe | 228 | 221 | 7 |
| 1992-06-12 | @ MIN | 57 | L 1-5 | 28-29 | 4 | 37,543 | Charlie Hough | John Smiley | John Smiley | Charlie Hough | Rick Aguilera | 229 | 226 | 3 |
| 1992-06-13 | @ MIN | 58 | W 4-2 | 29-29 | 4 | 45,867 | Jack McDowell | Scott Erickson | Jack McDowell | Scott Erickson | Bobby Thigpen | 233 | 228 | 5 |
| 1992-06-14 | @ MIN | 59 | L 7-8 | 29-30 | 4 | 46,668 | Greg Hibbard | Kevin Tapani | Tom Edens | Scott Radinsky | | 240 | 236 | 4 |
| 1992-06-15 | @ SEA | 60 | L 1-4 | 29-31 | 4 | 27,188 | Kirk McCaskill | Rich DeLucia | Rich DeLucia | Kirk McCaskill | Russ Swan | 241 | 240 | 1 |
| 1992-06-16 | @ SEA | 61 | L 6-9 | 29-32 | 4 | 13,912 | Alex Fernandez | Mike Walker | Eric Gunderson | Scott Radinsky | Mike Schooler | 247 | 249 | -2 |
| 1992-06-17 | @ SEA | 62 | L 1-2 | 29-33 | 4 | 15,509 | Charlie Hough | Erik Hanson | Erik Hanson | Charlie Hough | Mike Schooler | 248 | 251 | -3 |
| 1992-06-18 | @ SEA | 63 | L 4-5 | 29-34 | 4 | 19,840 | Jack McDowell | Randy Kramer | Eric Gunderson | Wilson Alvarez | | 252 | 256 | -4 |
| 1992-06-19 | vs DET | 64 | L 3-8 | 29-35 | 4 | 39,066 | Greg Hibbard | Frank Tanana | Walt Terrell | Wilson Alvarez | | 255 | 264 | -9 |
| 1992-06-20 | vs DET | 65 | W 3-1 | 30-35 | 4 | 42,253 | Kirk McCaskill | Buddy Groom | Kirk McCaskill | Buddy Groom | Bobby Thigpen | 258 | 265 | -7 |
| 1992-06-21 | vs DET | 66 | W 6-5 | 31-35 | 4 | 40,049 | Alex Fernandez | Bill Gullickson | Roberto Hernandez | Walt Terrell | Bobby Thigpen | 264 | 270 | -6 |
| 1992-06-22 | vs CLE | 67 | W 7-1 | 32-35 | 4 | 32,967 | Charlie Hough | Charles Nagy | Charlie Hough | Charles Nagy | | 271 | 271 | 0 |
| 1992-06-23 | vs CLE | 68 | W 7-1 | 33-35 | 4 | 36,972 | Jack McDowell | Dave Otto | Jack McDowell | Dave Otto | | 278 | 272 | 6 |
| 1992-06-24 | vs CLE | 69 | W 4-3 | 34-35 | 4 | 30,575 | Greg Hibbard | Scott Scudder | Roberto Hernandez | Ted Power | | 282 | 275 | 7 |
| 1992-06-26 | @ NYA | 70 | W 2-1 | 35-35 | 4 | 26,603 | Kirk McCaskill | Tim Leary | Kirk McCaskill | John Habyan | Scott Radinsky | 284 | 276 | 8 |
| 1992-06-27 | @ NYA | 71 | L 7-8 | 35-36 | 4 | 42,225 | Wilson Alvarez | Scott Kamieniecki | Tim Burke | Scott Radinsky | | 291 | 284 | 7 |
| 1992-06-28 | @ NYA | 72 | W 6-3 | 36-36 | 4 | 26,251 | Charlie Hough | Melido Perez | Charlie Hough | Melido Perez | Bobby Thigpen | 297 | 287 | 10 |
| 1992-06-29 | @ CLE | 73 | W 9-6 | 37-36 | 4 | 8,331 | Jack McDowell | Scott Scudder | Jack McDowell | Scott Scudder | Bobby Thigpen | 306 | 293 | 13 |
| 1992-06-30 | @ CLE | 74 | L 4-5 | 37-37 | 4 | 16,956 | Greg Hibbard | Denis Boucher | Derek Lilliquist | Terry Leach | | 310 | 298 | 12 |
| 1992-07-01 | @ CLE | 75 | W 8-5 | 38-37 | 4 | 11,302 | Kirk McCaskill | Jack Armstrong | Kirk McCaskill | Jack Armstrong | Bobby Thigpen | 318 | 303 | 15 |
| 1992-07-02 | vs BOS | 76 | W 8-3 | 39-37 | 4 | 32,448 | Wilson Alvarez | Roger Clemens | Wilson Alvarez | Roger Clemens | Roberto Hernandez | 326 | 306 | 20 |
| 1992-07-03 | vs BOS | 77 | W 2-1 | 40-37 | 4 | 35,584 | Charlie Hough | Frank Viola | Bobby Thigpen | Greg Harris | | 328 | 307 | 21 |
| 1992-07-04 | vs BOS | 78 | L 1-2 | 40-38 | 4 | 42,285 | Jack McDowell | Joe Hesketh | Joe Hesketh | Jack McDowell | Jeff Reardon | 329 | 309 | 20 |
| 1992-07-05 | vs BOS | 79 | W 4-2 | 41-38 | 4 | 40,088 | Greg Hibbard | Mike Gardiner | Greg Hibbard | Mike Gardiner | Scott Radinsky | 333 | 311 | 22 |
| 1992-07-06 | @ BAL | 80 | L 3-4 | 41-39 | 4 | 45,990 | Kirk McCaskill | Ben McDonald | Alan Mills | Roberto Hernandez | | 336 | 315 | 21 |
| 1992-07-07 | @ BAL | 81 | W 8-4 | 42-39 | 4 | 45,451 | Wilson Alvarez | Bob Milacki | Wilson Alvarez | Bob Milacki | | 344 | 319 | 25 |
| 1992-07-08 | @ BAL | 82 | L 3-5 | 42-40 | 4 | 45,721 | Charlie Hough | Mike Mussina | Alan Mills | Charlie Hough | Todd Frohwirth | 347 | 324 | 23 |
| 1992-07-09 | @ BOS | 83 | W 10-3 | 43-40 | 4 | 33,357 | Jack McDowell | Joe Hesketh | Jack McDowell | Joe Hesketh | | 357 | 327 | 30 |
| 1992-07-10 | @ BOS | 84 | L 5-6 | 43-41 | 4 | 34,288 | Greg Hibbard | Roger Clemens | Jeff Reardon | Terry Leach | | 362 | 333 | 29 |
| 1992-07-11 | @ BOS | 85 | L 2-11 | 43-42 | 4 | 34,288 | Kirk McCaskill | John Dopson | John Dopson | Kirk McCaskill | | 364 | 344 | 20 |
| 1992-07-12 | @ BOS | 86 | L 0-3 | 43-43 | 4 | 34,105 | Wilson Alvarez | Frank Viola | Frank Viola | Wilson Alvarez | Greg Harris | 364 | 347 | 17 |
| 1992-07-16 | vs MIL | 87 | W 5-4 | 44-43 | 4 | 35,223 | Kirk McCaskill | Bill Wegman | Roberto Hernandez | Dan Plesac | | 369 | 351 | 18 |
| 1992-07-17 | vs MIL | 88 | L 3-4 | 44-44 | 4 | 34,525 | Alex Fernandez | Jaime Navarro | Dan Plesac | Scott Radinsky | Doug Henry | 372 | 355 | 17 |
| 1992-07-18 | vs MIL | 89 | L 1-3 | 44-45 | 4 | 43,350 | Jack McDowell | Ricky Bones | Ricky Bones | Jack McDowell | Doug Henry | 373 | 358 | 15 |
| 1992-07-19 | vs MIL | 90 | L 3-6 | 44-46 | 4 | 41,731 | Greg Hibbard | Cal Eldred | Cal Eldred | Greg Hibbard | Doug Henry | 376 | 364 | 12 |
| 1992-07-20 | vs BAL | 91 | L 2-3 | 44-47 | 4 | 40,833 | Charlie Hough | Storm Davis | Pat Clements | Roberto Hernandez | Gregg Olson | 378 | 367 | 11 |
| 1992-07-21 | vs BAL | 92 | W 10-7 | 45-47 | 4 | 35,366 | Kirk McCaskill | Rick Sutcliffe | Terry Leach | Todd Frohwirth | | 388 | 374 | 14 |
| 1992-07-22 | vs BAL | 93 | W 7-5 | 46-47 | 4 | 36,349 | Alex Fernandez | Mike Mussina | Donn Pall | Gregg Olson | Scott Radinsky | 395 | 379 | 16 |
| 1992-07-23 | @ MIL | 94 | W 6-2 | 47-47 | 4 | 28,310 | Jack McDowell | Ricky Bones | Jack McDowell | Ricky Bones | Scott Radinsky | 401 | 381 | 20 |
| 1992-07-24 | @ MIL | 95 | L 2-3 | 47-48 | 4 | 27,898 | Greg Hibbard | Cal Eldred | Mike Fetters | Terry Leach | Doug Henry | 403 | 384 | 19 |
| 1992-07-25 | @ MIL | 96 | L 0-3 | 47-49 | 4 | 48,523 | Charlie Hough | Chris Bosio | Chris Bosio | Charlie Hough | | 403 | 387 | 16 |
| 1992-07-26 | @ MIL | 97 | L 4-15 | 47-50 | 4 | 48,129 | Kirk McCaskill | Bill Wegman | Bill Wegman | Kirk McCaskill | | 407 | 402 | 5 |
| 1992-07-28 | @ DET | 98 | W 8-6 | 49-50 | 4 | 0 | Jack McDowell | Bill Gullickson | Jack McDowell | Bill Gullickson | Scott Radinsky | 415 | 408 | 7 |
| 1992-07-28 | @ DET | 99 | W 5-3 | 49-50 | 4 | 22,688 | Alex Fernandez | Buddy Groom | Alex Fernandez | Buddy Groom | Bobby Thigpen | 420 | 411 | 9 |
| 1992-07-29 | @ DET | 100 | W 8-6 | 50-50 | 4 | 21,061 | Greg Hibbard | Kevin Ritz | Terry Leach | Mike Munoz | Scott Radinsky | 428 | 417 | 11 |
| 1992-07-31 | vs SEA | 101 | L 3-6 | 50-51 | 4 | 34,813 | Charlie Hough | Randy Johnson | Randy Johnson | Charlie Hough | Russ Swan | 431 | 423 | 8 |
| 1992-08-01 | vs SEA | 102 | W 8-1 | 51-51 | 4 | 42,761 | Kirk McCaskill | Erik Hanson | Kirk McCaskill | Erik Hanson | Greg Hibbard | 439 | 424 | 15 |
| 1992-08-02 | vs SEA | 103 | W 7-4 | 52-51 | 4 | 34,863 | Jack McDowell | Dave Fleming | Jack McDowell | Dave Fleming | Scott Radinsky | 446 | 428 | 18 |
| 1992-08-04 | vs MIN | 104 | W 19-11 | 53-51 | 3 | 35,841 | Alex Fernandez | Bill Krueger | Wilson Alvarez | Bill Krueger | Donn Pall | 465 | 439 | 26 |
| 1992-08-05 | vs MIN | 105 | W 9-5 | 54-51 | 3 | 36,132 | Charlie Hough | Kevin Tapani | Charlie Hough | Kevin Tapani | | 474 | 444 | 30 |
| 1992-08-06 | vs MIN | 106 | W 5-3 | 55-51 | 3 | 40,961 | Kirk McCaskill | John Smiley | Kirk McCaskill | John Smiley | Roberto Hernandez | 479 | 447 | 32 |
| 1992-08-07 | @ CAL | 107 | L 1-3 | 55-52 | 3 | 26,555 | Jack McDowell | Mark Langston | Mark Langston | Jack McDowell | Joe Grahe | 480 | 450 | 30 |
| 1992-08-08 | @ CAL | 108 | W 8-2 | 56-52 | 3 | 29,349 | Greg Hibbard | Jim Abbott | Roberto Hernandez | Steve Frey | | 488 | 452 | 36 |
| 1992-08-09 | @ CAL | 109 | W 12-8 | 57-52 | 3 | 25,401 | Alex Fernandez | Bert Blyleven | Donn Pall | Scott Bailes | | 500 | 460 | 40 |
| 1992-08-10 | @ OAK | 110 | L 3-5 | 57-53 | 3 | 31,374 | Charlie Hough | Ron Darling | Ron Darling | Charlie Hough | Dennis Eckersley | 503 | 465 | 38 |
| 1992-08-11 | @ OAK | 111 | W 10-6 | 58-53 | 3 | 27,550 | Kirk McCaskill | Kelly Downs | Roberto Hernandez | Rick Honeycutt | Scott Radinsky | 513 | 471 | 42 |
| 1992-08-12 | @ OAK | 112 | L 1-2 | 58-54 | 3 | 34,767 | Jack McDowell | Kevin Campbell | Dennis Eckersley | Jack McDowell | | 514 | 473 | 41 |
| 1992-08-14 | vs NYA | 113 | W 6-2 | 59-54 | 3 | 40,001 | Alex Fernandez | Scott Kamieniecki | Scott Radinsky | Scott Kamieniecki | Roberto Hernandez | 520 | 475 | 45 |
| 1992-08-15 | vs NYA | 114 | L 2-4 | 59-55 | 3 | 42,834 | Charlie Hough | Sam Militello | Sam Militello | Charlie Hough | Steve Farr | 522 | 479 | 43 |
| 1992-08-16 | vs NYA | 115 | W 4-2 | 60-55 | 3 | 34,723 | Kirk McCaskill | Shawn Hillegas | Kirk McCaskill | Shawn Hillegas | Scott Radinsky | 526 | 481 | 45 |
| 1992-08-17 | vs NYA | 116 | W 4-3 | 61-55 | 3 | 38,553 | Greg Hibbard | Melido Perez | Greg Hibbard | Melido Perez | Scott Radinsky | 530 | 484 | 46 |
| 1992-08-18 | vs TEX | 117 | W 3-0 | 62-55 | 3 | 29,564 | Jack McDowell | Kevin Brown | Jack McDowell | Kevin Brown | | 533 | 484 | 49 |
| 1992-08-19 | vs TEX | 118 | W 3-2 | 63-55 | 3 | 31,227 | Alex Fernandez | Jose Guzman | Alex Fernandez | Jose Guzman | Scott Radinsky | 536 | 486 | 50 |
| 1992-08-20 | vs TEX | 119 | L 1-6 | 63-56 | 3 | 31,959 | Charlie Hough | Roger Pavlik | Roger Pavlik | Charlie Hough | | 537 | 492 | 45 |
| 1992-08-21 | vs KCA | 120 | L 3-4 | 63-57 | 3 | 31,761 | Kirk McCaskill | Luis Aquino | Rusty Meacham | Kirk McCaskill | Jeff Montgomery | 540 | 496 | 44 |
| 1992-08-22 | vs KCA | 121 | W 3-2 | 64-57 | 3 | 41,344 | Greg Hibbard | Hipolito Pichardo | Greg Hibbard | Hipolito Pichardo | Scott Radinsky | 543 | 498 | 45 |
| 1992-08-23 | vs KCA | 122 | W 3-1 | 65-57 | 3 | 37,112 | Jack McDowell | Rick Reed | Jack McDowell | Rick Reed | | 546 | 499 | 47 |
| 1992-08-24 | vs TOR | 123 | W 8-4 | 66-57 | 3 | 32,837 | Alex Fernandez | Doug Linton | Alex Fernandez | Doug Linton | | 554 | 503 | 51 |
| 1992-08-25 | vs TOR | 124 | W 6-3 | 67-57 | 3 | 29,450 | Charlie Hough | David Wells | Charlie Hough | David Wells | Roberto Hernandez | 560 | 506 | 54 |
| 1992-08-26 | vs TOR | 125 | L 0-9 | 67-58 | 3 | 26,436 | Kirk McCaskill | Todd Stottlemyre | Todd Stottlemyre | Kirk McCaskill | | 560 | 515 | 45 |
| 1992-08-28 | @ TEX | 126 | L 1-4 | 67-59 | 3 | 22,837 | Greg Hibbard | Kevin Brown | Kevin Brown | Greg Hibbard | | 561 | 519 | 42 |
| 1992-08-29 | @ TEX | 127 | W 6-4 | 68-59 | 3 | 34,863 | Jack McDowell | Bobby Witt | Jack McDowell | Bobby Witt | Roberto Hernandez | 567 | 523 | 44 |
| 1992-08-30 | @ TEX | 128 | L 4-10 | 68-60 | 3 | 16,275 | Alex Fernandez | Jose Guzman | Jose Guzman | Alex Fernandez | | 571 | 533 | 38 |
| 1992-08-31 | @ TOR | 129 | L 2-9 | 68-61 | 3 | 50,417 | Charlie Hough | Todd Stottlemyre | Todd Stottlemyre | Charlie Hough | | 573 | 542 | 31 |
| 1992-09-01 | @ TOR | 130 | L 3-9 | 68-62 | 3 | 50,409 | Kirk McCaskill | Jack Morris | Jack Morris | Kirk McCaskill | | 576 | 551 | 25 |
| 1992-09-02 | @ TOR | 131 | W 3-2 | 69-62 | 3 | 50,419 | Greg Hibbard | Jimmy Key | Greg Hibbard | Jimmy Key | Roberto Hernandez | 579 | 553 | 26 |
| 1992-09-03 | @ KCA | 132 | W 7-3 | 70-62 | 3 | 18,867 | Jack McDowell | Luis Aquino | Jack McDowell | Luis Aquino | | 586 | 556 | 30 |
| 1992-09-04 | @ KCA | 133 | W 8-0 | 71-62 | 3 | 18,513 | Alex Fernandez | Kevin Appier | Alex Fernandez | Kevin Appier | | 594 | 556 | 38 |
| 1992-09-05 | @ KCA | 134 | W 12-6 | 72-62 | 3 | 26,845 | Charlie Hough | Chris Haney | Wilson Alvarez | Juan Berenguer | | 606 | 562 | 44 |
| 1992-09-06 | @ KCA | 135 | L 2-3 | 72-63 | 3 | 25,166 | Kirk McCaskill | Ed Pierce | Tom Gordon | Roberto Hernandez | Jeff Montgomery | 608 | 565 | 43 |
| 1992-09-08 | vs DET | 136 | W 4-3 | 74-63 | 3 | 0 | Jack McDowell | Frank Tanana | Jack McDowell | Frank Tanana | Roberto Hernandez | 612 | 568 | 44 |
| 1992-09-08 | vs DET | 137 | W 4-3 | 74-63 | 3 | 26,784 | Mike Dunne | Eric King | Terry Leach | Mark Leiter | Scott Radinsky | 616 | 571 | 45 |
| 1992-09-09 | vs DET | 138 | W 6-4 | 75-63 | 3 | 23,117 | Wilson Alvarez | Bill Gullickson | Terry Leach | Bill Gullickson | Roberto Hernandez | 622 | 575 | 47 |
| 1992-09-10 | vs DET | 139 | L 0-8 | 75-64 | 3 | 25,963 | Alex Fernandez | Dave Haas | Dave Haas | Alex Fernandez | | 622 | 583 | 39 |
| 1992-09-11 | vs CLE | 140 | L 1-5 | 75-65 | 3 | 30,983 | Greg Hibbard | Charles Nagy | Charles Nagy | Greg Hibbard | | 623 | 588 | 35 |
| 1992-09-12 | vs CLE | 141 | L 3-5 | 75-66 | 3 | 34,768 | Kirk McCaskill | Dave Mlicki | Eric Plunk | Kirk McCaskill | Steve Olin | 626 | 593 | 33 |
| 1992-09-13 | vs CLE | 142 | L 1-2 | 75-67 | 3 | 34,235 | Jack McDowell | Dennis Cook | Eric Plunk | Bobby Thigpen | Steve Olin | 627 | 595 | 32 |
| 1992-09-14 | @ NYA | 143 | W 8-6 | 76-67 | 3 | 12,566 | Wilson Alvarez | Bob Wickman | Wilson Alvarez | Bob Wickman | Roberto Hernandez | 635 | 601 | 34 |
| 1992-09-15 | @ NYA | 144 | W 4-2 | 77-67 | 3 | 13,266 | Alex Fernandez | Sam Militello | Alex Fernandez | Rich Monteleone | Bobby Thigpen | 639 | 603 | 36 |
| 1992-09-16 | @ NYA | 145 | W 9-6 | 78-67 | 3 | 12,909 | Greg Hibbard | Sterling Hitchcock | Terry Leach | Sterling Hitchcock | Roberto Hernandez | 648 | 609 | 39 |
| 1992-09-18 | @ CLE | 146 | W 8-7 | 79-67 | 3 | 25,861 | Kirk McCaskill | Dave Mlicki | Kirk McCaskill | Dave Mlicki | Roberto Hernandez | 656 | 616 | 40 |
| 1992-09-19 | @ CLE | 147 | L 4-5 | 79-68 | 3 | 13,014 | Jack McDowell | Dennis Cook | Eric Plunk | Jack McDowell | Steve Olin | 660 | 621 | 39 |
| 1992-09-20 | @ CLE | 148 | W 10-8 | 80-68 | 3 | 13,457 | Wilson Alvarez | Jose Mesa | Mike Dunne | Jose Mesa | Bobby Thigpen | 670 | 629 | 41 |
| 1992-09-21 | vs OAK | 149 | L 5-6 | 80-69 | 3 | 29,529 | Alex Fernandez | Ron Darling | Ron Darling | Alex Fernandez | Dennis Eckersley | 675 | 635 | 40 |
| 1992-09-22 | vs OAK | 150 | W 8-3 | 81-69 | 3 | 25,891 | Charlie Hough | Bobby Witt | Charlie Hough | Bobby Witt | | 683 | 638 | 45 |
| 1992-09-23 | vs OAK | 151 | W 17-6 | 82-69 | 3 | 26,279 | Kirk McCaskill | Mike Moore | Kirk McCaskill | Mike Moore | | 700 | 644 | 56 |
| 1992-09-24 | vs OAK | 152 | L 1-4 | 82-70 | 3 | 26,817 | Jack McDowell | Bob Welch | Bob Welch | Jack McDowell | Dennis Eckersley | 701 | 648 | 53 |
| 1992-09-25 | vs CAL | 153 | W 6-5 | 83-70 | 3 | 30,776 | Wilson Alvarez | Julio Valera | Roberto Hernandez | Joe Grahe | | 707 | 653 | 54 |
| 1992-09-26 | vs CAL | 154 | L 0-1 | 83-71 | 3 | 36,207 | Alex Fernandez | Chuck Finley | Chuck Finley | Alex Fernandez | Steve Frey | 707 | 654 | 53 |
| 1992-09-27 | vs CAL | 155 | W 3-2 | 84-71 | 3 | 30,865 | Charlie Hough | Mark Langston | Roberto Hernandez | Chuck Crim | | 710 | 656 | 54 |
| 1992-09-28 | @ MIN | 156 | W 9-4 | 85-71 | 3 | 16,329 | Kirk McCaskill | Pat Mahomes | Kirk McCaskill | Pat Mahomes | | 719 | 660 | 59 |
| 1992-09-29 | @ MIN | 157 | L 4-5 | 85-72 | 3 | 20,842 | Jack McDowell | Mike Trombley | Tom Edens | Scott Radinsky | | 723 | 665 | 58 |
| 1992-09-30 | @ MIN | 158 | W 4-3 | 86-72 | 3 | 17,501 | Wilson Alvarez | Scott Erickson | Mike Dunne | Scott Erickson | Roberto Hernandez | 727 | 668 | 59 |
| 1992-10-01 | @ MIN | 159 | L 6-9 | 86-73 | 3 | 15,656 | Alex Fernandez | Kevin Tapani | Carl Willis | Terry Leach | Rick Aguilera | 733 | 677 | 56 |
| 1992-10-02 | @ SEA | 160 | L 0-2 | 86-74 | 3 | 26,770 | Charlie Hough | Dave Fleming | Dave Fleming | Charlie Hough | | 733 | 679 | 54 |
| 1992-10-03 | @ SEA | 161 | L 2-7 | 86-75 | 3 | 14,866 | Kirk McCaskill | Randy Johnson | Randy Johnson | Kirk McCaskill | | 735 | 686 | 49 |
| 1992-10-04 | @ SEA | 162 | L 3-4 | 86-76 | 3 | 15,591 | Jack McDowell | Brian Fisher | Brian Fisher | Jack McDowell | Jeff Nelson | 738 | 690 | 48 |