| 1992-04-07 | @ NYA | 1 | L 3-4 | 0-1 | 4 | 56,572 | Roger Clemens | Scott Sanderson | Scott Sanderson | Roger Clemens | Steve Farr | 3 | 4 | -1 |
| 1992-04-09 | @ NYA | 2 | L 2-3 | 0-2 | 6 | 20,430 | Frank Viola | Jeff Johnson | Rich Monteleone | Frank Viola | Steve Howe | 5 | 7 | -2 |
| 1992-04-11 | @ CLE | 3 | W 7-5 | 1-2 | 5 | 65,813 | Joe Hesketh | Dennis Cook | Mike Gardiner | Eric Bell | | 12 | 12 | 0 |
| 1992-04-12 | @ CLE | 4 | L 1-2 | 2-3 | 3 | 0 | Matt Young | Charles Nagy | Charles Nagy | Matt Young | Derek Lilliquist | 13 | 14 | -1 |
| 1992-04-12 | @ CLE | 5 | W 3-0 | 2-3 | 3 | 20,480 | Roger Clemens | Scott Scudder | Roger Clemens | Scott Scudder | | 16 | 14 | 2 |
| 1992-04-13 | vs BAL | 6 | L 6-8 | 2-4 | 4 | 34,472 | Frank Viola | Bob Milacki | Todd Frohwirth | Tony Fossas | Gregg Olson | 22 | 22 | 0 |
| 1992-04-15 | vs BAL | 7 | W 6-5 | 3-4 | 4 | 27,185 | Mike Gardiner | Ben McDonald | Greg Harris | Storm Davis | Jeff Reardon | 28 | 27 | 1 |
| 1992-04-17 | vs TOR | 8 | W 1-0 | 4-4 | 4 | 27,467 | Roger Clemens | David Wells | Roger Clemens | David Wells | Jeff Reardon | 29 | 27 | 2 |
| 1992-04-18 | vs TOR | 9 | L 1-2 | 4-5 | 5 | 32,640 | Frank Viola | Todd Stottlemyre | Todd Stottlemyre | Frank Viola | Tom Henke | 30 | 29 | 1 |
| 1992-04-19 | vs TOR | 10 | W 5-4 | 5-5 | 4 | 28,196 | Matt Young | Juan Guzman | Danny Darwin | Tom Henke | | 35 | 33 | 2 |
| 1992-04-20 | vs TOR | 11 | L 4-6 | 5-6 | 4 | 34,709 | Joe Hesketh | Jimmy Key | Bob Macdonald | Tom Bolton | | 39 | 39 | 0 |
| 1992-04-21 | @ MIL | 12 | W 3-1 | 6-6 | 4 | 8,257 | Mike Gardiner | Ricky Bones | Mike Gardiner | Jim Austin | Danny Darwin | 42 | 40 | 2 |
| 1992-04-23 | @ MIL | 13 | L 2-3 | 6-7 | 4 | 9,740 | Roger Clemens | Bill Wegman | Bill Wegman | Roger Clemens | Doug Henry | 44 | 43 | 1 |
| 1992-04-24 | vs TEX | 14 | W 3-1 | 7-7 | 4 | 31,461 | Frank Viola | Jose Guzman | Frank Viola | Jose Guzman | | 47 | 44 | 3 |
| 1992-04-26 | vs TEX | 15 | L 1-3 | 7-9 | 5 | 0 | Matt Young | Bobby Witt | Bobby Witt | Matt Young | Jeff Russell | 48 | 47 | 1 |
| 1992-04-26 | vs TEX | 16 | L 2-4 | 7-9 | 5 | 32,728 | Joe Hesketh | Jeff Robinson | Terry Mathews | Greg Harris | Jeff Russell | 50 | 51 | -1 |
| 1992-04-28 | vs CHA | 17 | W 6-3 | 8-9 | 4 | 27,673 | Roger Clemens | Kirk McCaskill | Roger Clemens | Kirk McCaskill | Jeff Reardon | 56 | 54 | 2 |
| 1992-04-29 | vs CHA | 18 | W 6-1 | 9-9 | 4 | 27,205 | Frank Viola | Alex Fernandez | Frank Viola | Alex Fernandez | Jeff Reardon | 62 | 55 | 7 |
| 1992-05-01 | vs KCA | 19 | W 6-5 | 10-9 | 5 | 27,973 | Mike Gardiner | Mark Gubicza | Danny Darwin | Jeff Montgomery | | 68 | 60 | 8 |
| 1992-05-02 | vs KCA | 20 | W 7-6 | 11-9 | 5 | 31,978 | Matt Young | Mark Davis | Greg Harris | Hipolito Pichardo | Jeff Reardon | 75 | 66 | 9 |
| 1992-05-03 | vs KCA | 21 | L 2-5 | 11-10 | 5 | 33,368 | Joe Hesketh | Kevin Appier | Kevin Appier | Joe Hesketh | Jeff Montgomery | 77 | 71 | 6 |
| 1992-05-04 | vs MIN | 22 | L 1-6 | 11-11 | 5 | 25,843 | Roger Clemens | John Smiley | John Smiley | Roger Clemens | | 78 | 77 | 1 |
| 1992-05-05 | vs MIN | 23 | W 4-1 | 12-11 | 4 | 25,009 | Frank Viola | Pat Mahomes | Frank Viola | Pat Mahomes | Jeff Reardon | 82 | 78 | 4 |
| 1992-05-06 | @ CHA | 24 | L 5-7 | 12-12 | 4 | 25,338 | Mike Gardiner | Greg Hibbard | Scott Radinsky | Danny Darwin | Bobby Thigpen | 87 | 85 | 2 |
| 1992-05-07 | @ CHA | 25 | L 6-7 | 12-13 | 4 | 25,582 | Matt Young | Charlie Hough | Donn Pall | Greg Harris | Bobby Thigpen | 93 | 92 | 1 |
| 1992-05-08 | @ KCA | 26 | L 1-2 | 12-14 | 4 | 22,063 | Joe Hesketh | Kevin Appier | Kevin Appier | Joe Hesketh | Jeff Montgomery | 94 | 94 | 0 |
| 1992-05-09 | @ KCA | 27 | W 5-0 | 13-14 | 4 | 28,444 | Roger Clemens | Tom Gordon | Roger Clemens | Tom Gordon | | 99 | 94 | 5 |
| 1992-05-10 | @ KCA | 28 | W 10-6 | 14-14 | 3 | 19,180 | Frank Viola | Mike Magnante | Frank Viola | Mike Magnante | | 109 | 100 | 9 |
| 1992-05-12 | @ MIN | 29 | L 3-6 | 14-15 | 4 | 19,270 | Mike Gardiner | Kevin Tapani | Kevin Tapani | Mike Gardiner | Rick Aguilera | 112 | 106 | 6 |
| 1992-05-13 | @ MIN | 30 | L 3-4 | 14-16 | 4 | 21,472 | Joe Hesketh | Bill Krueger | Tom Edens | Greg Harris | | 115 | 110 | 5 |
| 1992-05-15 | vs CAL | 31 | W 3-0 | 15-16 | 4 | 33,254 | Roger Clemens | Jim Abbott | Roger Clemens | Jim Abbott | | 118 | 110 | 8 |
| 1992-05-16 | vs CAL | 32 | W 3-0 | 16-16 | 4 | 33,247 | Frank Viola | Julio Valera | Frank Viola | Julio Valera | Jeff Reardon | 121 | 110 | 11 |
| 1992-05-17 | vs CAL | 33 | L 1-3 | 16-17 | 4 | 32,554 | John Dopson | Mark Langston | Mark Langston | John Dopson | Bryan Harvey | 122 | 113 | 9 |
| 1992-05-18 | vs SEA | 34 | W 3-2 | 17-17 | 4 | 24,377 | Mike Gardiner | Erik Hanson | Mike Gardiner | Erik Hanson | Jeff Reardon | 125 | 115 | 10 |
| 1992-05-19 | vs SEA | 35 | W 7-5 | 18-17 | 4 | 27,091 | Joe Hesketh | Russ Swan | Tom Bolton | Jeff Nelson | Jeff Reardon | 132 | 120 | 12 |
| 1992-05-20 | vs SEA | 36 | W 6-4 | 19-17 | 4 | 32,055 | Roger Clemens | Dave Fleming | Roger Clemens | Dennis Powell | Jeff Reardon | 138 | 124 | 14 |
| 1992-05-22 | vs OAK | 37 | L 3-5 | 19-18 | 4 | 33,591 | Frank Viola | Dave Stewart | Dave Stewart | Frank Viola | Dennis Eckersley | 141 | 129 | 12 |
| 1992-05-23 | vs OAK | 38 | W 5-1 | 20-18 | 4 | 33,186 | John Dopson | Mike Moore | John Dopson | Mike Moore | | 146 | 130 | 16 |
| 1992-05-24 | vs OAK | 39 | L 0-4 | 20-19 | 4 | 33,965 | Mike Gardiner | Ron Darling | Ron Darling | Mike Gardiner | | 146 | 134 | 12 |
| 1992-05-26 | @ CAL | 40 | W 4-1 | 21-19 | 4 | 23,649 | Roger Clemens | Jim Abbott | Roger Clemens | Jim Abbott | Jeff Reardon | 150 | 135 | 15 |
| 1992-05-27 | @ CAL | 41 | W 4-3 | 22-19 | 4 | 23,127 | Frank Viola | Julio Valera | Jeff Reardon | Bryan Harvey | Danny Darwin | 154 | 138 | 16 |
| 1992-05-28 | @ CAL | 42 | W 2-1 | 23-19 | 4 | 23,843 | Joe Hesketh | Mark Langston | Joe Hesketh | Mark Langston | Jeff Reardon | 156 | 139 | 17 |
| 1992-05-29 | @ SEA | 43 | L 3-7 | 23-20 | 4 | 18,270 | John Dopson | Clay Parker | Dennis Powell | John Dopson | | 159 | 146 | 13 |
| 1992-05-30 | @ SEA | 44 | L 0-3 | 23-21 | 4 | 40,484 | Mike Gardiner | Dave Fleming | Dave Fleming | Mike Gardiner | | 159 | 149 | 10 |
| 1992-05-31 | @ SEA | 45 | W 7-1 | 24-21 | 4 | 39,005 | Roger Clemens | Randy Johnson | Roger Clemens | Randy Johnson | | 166 | 150 | 16 |
| 1992-06-01 | @ OAK | 46 | L 7-10 | 24-22 | 4 | 24,518 | Frank Viola | Dave Stewart | Kevin Campbell | Danny Darwin | | 173 | 160 | 13 |
| 1992-06-02 | @ OAK | 47 | L 4-5 | 24-23 | 4 | 25,553 | Joe Hesketh | Mike Moore | Mike Moore | Joe Hesketh | Dennis Eckersley | 177 | 165 | 12 |
| 1992-06-03 | @ OAK | 48 | L 6-7 | 24-24 | 4 | 31,294 | John Dopson | Joe Slusarski | Jeff Parrett | Mike Gardiner | Dennis Eckersley | 183 | 172 | 11 |
| 1992-06-06 | vs CLE | 49 | W 5-1 | 25-25 | 5 | 0 | Roger Clemens | Jack Armstrong | Roger Clemens | Jack Armstrong | | 188 | 173 | 15 |
| 1992-06-06 | vs CLE | 50 | L 1-3 | 25-25 | 5 | 32,937 | Frank Viola | Charles Nagy | Charles Nagy | Frank Viola | Steve Olin | 189 | 176 | 13 |
| 1992-06-07 | vs CLE | 51 | W 4-0 | 26-25 | 5 | 33,202 | Joe Hesketh | Dave Otto | Joe Hesketh | Dave Otto | Danny Darwin | 193 | 176 | 17 |
| 1992-06-08 | @ BAL | 52 | L 2-5 | 26-26 | 5 | 46,061 | Mike Gardiner | Bob Milacki | Bob Milacki | Mike Gardiner | Gregg Olson | 195 | 181 | 14 |
| 1992-06-09 | @ BAL | 53 | W 4-1 | 27-26 | 4 | 46,085 | John Dopson | Jose Mesa | John Dopson | Jose Mesa | Jeff Reardon | 199 | 182 | 17 |
| 1992-06-10 | @ BAL | 54 | L 1-3 | 27-27 | 4 | 45,733 | Tom Bolton | Rick Sutcliffe | Rick Sutcliffe | Tom Bolton | Gregg Olson | 200 | 185 | 15 |
| 1992-06-11 | @ TOR | 55 | L 0-4 | 27-28 | 5 | 50,423 | Roger Clemens | Jack Morris | Jack Morris | Roger Clemens | | 200 | 189 | 11 |
| 1992-06-12 | @ TOR | 56 | W 5-0 | 28-28 | 4 | 50,387 | Frank Viola | Dave Stieb | Frank Viola | Dave Stieb | | 205 | 189 | 16 |
| 1992-06-13 | @ TOR | 57 | W 5-3 | 29-28 | 4 | 50,397 | Joe Hesketh | Todd Stottlemyre | Joe Hesketh | Todd Stottlemyre | Jeff Reardon | 210 | 192 | 18 |
| 1992-06-14 | @ TOR | 58 | L 2-6 | 29-29 | 4 | 50,412 | Mike Gardiner | Juan Guzman | Juan Guzman | Mike Gardiner | Duane Ward | 212 | 198 | 14 |
| 1992-06-15 | vs NYA | 59 | W 1-0 | 30-29 | 4 | 33,577 | John Dopson | Scott Sanderson | John Dopson | Scott Sanderson | Jeff Reardon | 213 | 198 | 15 |
| 1992-06-16 | vs NYA | 60 | W 4-3 | 31-29 | 4 | 34,592 | Roger Clemens | Tim Leary | Danny Darwin | Greg Cadaret | | 217 | 201 | 16 |
| 1992-06-17 | vs NYA | 61 | W 4-3 | 32-29 | 4 | 33,916 | Frank Viola | Scott Kamieniecki | Frank Viola | Scott Kamieniecki | Tony Fossas | 221 | 204 | 17 |
| 1992-06-18 | vs NYA | 62 | L 4-5 | 32-30 | 4 | 34,076 | Joe Hesketh | Melido Perez | Melido Perez | Danny Darwin | Steve Farr | 225 | 209 | 16 |
| 1992-06-19 | @ TEX | 63 | L 1-4 | 32-31 | 4 | 32,025 | Mike Gardiner | Bobby Witt | Bobby Witt | Mike Gardiner | Jeff Russell | 226 | 213 | 13 |
| 1992-06-20 | @ TEX | 64 | L 1-4 | 32-32 | 4 | 40,401 | John Dopson | Kevin Brown | Kevin Brown | John Dopson | Kenny Rogers | 227 | 217 | 10 |
| 1992-06-21 | @ TEX | 65 | L 2-3 | 32-33 | 5 | 32,648 | Roger Clemens | Todd Burns | Todd Burns | Roger Clemens | Jeff Russell | 229 | 220 | 9 |
| 1992-06-22 | @ DET | 66 | L 2-4 | 32-34 | 5 | 19,040 | Frank Viola | Kevin Ritz | Kurt Knudsen | Danny Darwin | | 231 | 224 | 7 |
| 1992-06-23 | @ DET | 67 | L 7-11 | 32-35 | 5 | 14,134 | Joe Hesketh | Mark Leiter | John Kiely | Joe Hesketh | | 238 | 235 | 3 |
| 1992-06-24 | @ DET | 68 | L 1-5 | 32-36 | 5 | 20,834 | Mike Gardiner | Frank Tanana | Frank Tanana | Mike Gardiner | | 239 | 240 | -1 |
| 1992-06-26 | vs MIL | 69 | W 8-4 | 33-36 | 5 | 33,637 | John Dopson | Ron Robinson | John Dopson | Ron Robinson | | 247 | 244 | 3 |
| 1992-06-27 | vs MIL | 70 | W 8-7 | 34-36 | 5 | 33,734 | Roger Clemens | Bruce Ruffin | Danny Darwin | Darren Holmes | | 255 | 251 | 4 |
| 1992-06-28 | vs MIL | 71 | L 3-9 | 34-37 | 5 | 33,237 | Frank Viola | Jaime Navarro | Jaime Navarro | Frank Viola | | 258 | 260 | -2 |
| 1992-06-29 | vs DET | 72 | L 3-8 | 34-38 | 5 | 33,388 | Joe Hesketh | Frank Tanana | Frank Tanana | Joe Hesketh | Kurt Knudsen | 261 | 268 | -7 |
| 1992-06-30 | vs DET | 73 | W 8-5 | 35-38 | 5 | 33,485 | Mike Gardiner | Buddy Groom | Daryl Irvine | Mike Henneman | | 269 | 273 | -4 |
| 1992-07-01 | vs DET | 74 | W 6-4 | 36-38 | 5 | 32,059 | John Dopson | Bill Gullickson | John Dopson | Bill Gullickson | Jeff Reardon | 275 | 277 | -2 |
| 1992-07-02 | @ CHA | 75 | L 3-8 | 36-39 | 5 | 32,448 | Roger Clemens | Wilson Alvarez | Wilson Alvarez | Roger Clemens | Roberto Hernandez | 278 | 285 | -7 |
| 1992-07-03 | @ CHA | 76 | L 1-2 | 36-40 | 5 | 35,584 | Frank Viola | Charlie Hough | Bobby Thigpen | Greg Harris | | 279 | 287 | -8 |
| 1992-07-04 | @ CHA | 77 | W 2-1 | 37-40 | 5 | 42,285 | Joe Hesketh | Jack McDowell | Joe Hesketh | Jack McDowell | Jeff Reardon | 281 | 288 | -7 |
| 1992-07-05 | @ CHA | 78 | L 2-4 | 37-41 | 5 | 40,088 | Mike Gardiner | Greg Hibbard | Greg Hibbard | Mike Gardiner | Scott Radinsky | 283 | 292 | -9 |
| 1992-07-06 | vs KCA | 79 | L 3-6 | 37-42 | 5 | 28,495 | John Dopson | Rick Reed | Rick Reed | John Dopson | Rusty Meacham | 286 | 298 | -12 |
| 1992-07-07 | vs KCA | 80 | W 3-2 | 38-42 | 5 | 30,078 | Greg Harris | Kevin Appier | Danny Darwin | Rusty Meacham | | 289 | 300 | -11 |
| 1992-07-08 | vs KCA | 81 | W 5-4 | 39-42 | 5 | 31,196 | Frank Viola | Hipolito Pichardo | Tony Fossas | Tom Gordon | Jeff Reardon | 294 | 304 | -10 |
| 1992-07-09 | vs CHA | 82 | L 3-10 | 39-43 | 6 | 33,357 | Joe Hesketh | Jack McDowell | Jack McDowell | Joe Hesketh | | 297 | 314 | -17 |
| 1992-07-10 | vs CHA | 83 | W 6-5 | 40-43 | 5 | 34,288 | Roger Clemens | Greg Hibbard | Jeff Reardon | Terry Leach | | 303 | 319 | -16 |
| 1992-07-11 | vs CHA | 84 | W 11-2 | 41-43 | 5 | 34,288 | John Dopson | Kirk McCaskill | John Dopson | Kirk McCaskill | | 314 | 321 | -7 |
| 1992-07-12 | vs CHA | 85 | W 3-0 | 42-43 | 4 | 34,105 | Frank Viola | Wilson Alvarez | Frank Viola | Wilson Alvarez | Greg Harris | 317 | 321 | -4 |
| 1992-07-16 | @ MIN | 86 | L 6-7 | 42-44 | 4 | 39,895 | Joe Hesketh | Kevin Tapani | Carl Willis | Mike Gardiner | Rick Aguilera | 323 | 328 | -5 |
| 1992-07-17 | @ MIN | 87 | L 2-3 | 42-45 | 4 | 42,368 | Frank Viola | John Smiley | Bob Kipper | Greg Harris | | 325 | 331 | -6 |
| 1992-07-18 | @ MIN | 88 | W 1-0 | 43-45 | 4 | 42,078 | Roger Clemens | Scott Erickson | Roger Clemens | Scott Erickson | | 326 | 331 | -5 |
| 1992-07-19 | @ MIN | 89 | L 5-7 | 43-46 | 4 | 38,735 | John Dopson | Bill Krueger | Mark Guthrie | Greg Harris | Rick Aguilera | 331 | 338 | -7 |
| 1992-07-20 | @ KCA | 90 | W 5-3 | 44-46 | 4 | 30,260 | Danny Darwin | Mike Boddicker | Paul Quantrill | Steve Shifflett | Jeff Reardon | 336 | 341 | -5 |
| 1992-07-21 | @ KCA | 91 | L 0-8 | 44-47 | 5 | 21,921 | Joe Hesketh | Hipolito Pichardo | Hipolito Pichardo | Joe Hesketh | | 336 | 349 | -13 |
| 1992-07-22 | @ KCA | 92 | L 4-6 | 44-48 | 6 | 22,978 | Frank Viola | Rick Reed | Tom Gordon | Frank Viola | Jeff Montgomery | 340 | 355 | -15 |
| 1992-07-24 | vs MIN | 93 | L 0-5 | 45-49 | 6 | 0 | Roger Clemens | Scott Erickson | Scott Erickson | Roger Clemens | | 340 | 360 | -20 |
| 1992-07-24 | vs MIN | 94 | W 5-4 | 45-49 | 6 | 34,614 | John Dopson | Bill Krueger | Daryl Irvine | Carl Willis | | 345 | 364 | -19 |
| 1992-07-25 | vs MIN | 95 | L 2-3 | 45-50 | 6 | 34,420 | Danny Darwin | Willie Banks | Willie Banks | Danny Darwin | Rick Aguilera | 347 | 367 | -20 |
| 1992-07-26 | vs MIN | 96 | L 2-8 | 45-51 | 6 | 33,095 | Joe Hesketh | Kevin Tapani | Kevin Tapani | Joe Hesketh | Mark Guthrie | 349 | 375 | -26 |
| 1992-07-27 | vs TEX | 97 | W 7-5 | 46-51 | 5 | 32,927 | Frank Viola | Kevin Brown | Frank Viola | Kevin Brown | Jeff Reardon | 356 | 380 | -24 |
| 1992-07-28 | vs TEX | 98 | L 1-2 | 46-52 | 5 | 33,188 | John Dopson | Jose Guzman | Danny Leon | Paul Quantrill | Jeff Russell | 357 | 382 | -25 |
| 1992-07-29 | vs TEX | 99 | W 6-5 | 47-52 | 4 | 31,587 | Roger Clemens | Todd Burns | Roger Clemens | Todd Burns | Jeff Reardon | 363 | 387 | -24 |
| 1992-07-31 | vs BAL | 100 | W 7-4 | 48-53 | 4 | 28,349 | Danny Darwin | Mike Mussina | Joe Hesketh | Todd Frohwirth | Jeff Reardon | 370 | 391 | -21 |
| 1992-07-31 | vs BAL | 101 | L 3-4 | 48-53 | 4 | 32,748 | Matt Young | Richie Lewis | Richie Lewis | Matt Young | Storm Davis | 373 | 395 | -22 |
| 1992-08-01 | vs BAL | 102 | L 3-9 | 48-54 | 4 | 33,788 | Frank Viola | Alan Mills | Pat Clements | Frank Viola | | 376 | 404 | -28 |
| 1992-08-02 | vs BAL | 103 | L 1-2 | 48-55 | 4 | 33,637 | John Dopson | Ben McDonald | Ben McDonald | Tony Fossas | Gregg Olson | 377 | 406 | -29 |
| 1992-08-03 | vs TOR | 104 | W 7-1 | 49-55 | 4 | 34,024 | Roger Clemens | Juan Guzman | Roger Clemens | Juan Guzman | | 384 | 407 | -23 |
| 1992-08-04 | vs TOR | 105 | W 9-4 | 50-55 | 4 | 33,294 | Joe Hesketh | David Wells | Joe Hesketh | David Wells | Greg Harris | 393 | 411 | -18 |
| 1992-08-05 | vs TOR | 106 | L 4-5 | 50-56 | 4 | 33,945 | Danny Darwin | Todd Stottlemyre | Mark Eichhorn | Daryl Irvine | Tom Henke | 397 | 416 | -19 |
| 1992-08-06 | @ NYA | 107 | W 3-1 | 51-56 | 4 | 34,496 | Frank Viola | Melido Perez | Frank Viola | Melido Perez | Jeff Reardon | 400 | 417 | -17 |
| 1992-08-07 | @ NYA | 108 | L 5-7 | 51-57 | 4 | 33,483 | John Dopson | Scott Sanderson | Scott Sanderson | John Dopson | Steve Farr | 405 | 424 | -19 |
| 1992-08-08 | @ NYA | 109 | W 4-2 | 52-57 | 4 | 48,774 | Roger Clemens | Scott Kamieniecki | Roger Clemens | Scott Kamieniecki | Jeff Reardon | 409 | 426 | -17 |
| 1992-08-09 | @ NYA | 110 | L 0-6 | 52-58 | 4 | 41,125 | Joe Hesketh | Sam Militello | Sam Militello | Joe Hesketh | Steve Farr | 409 | 432 | -23 |
| 1992-08-10 | @ CLE | 111 | L 5-8 | 52-59 | 4 | 9,225 | Danny Darwin | Dennis Cook | Jack Armstrong | Paul Quantrill | Steve Olin | 414 | 440 | -26 |
| 1992-08-11 | @ CLE | 112 | L 1-3 | 52-60 | 5 | 15,425 | Frank Viola | Dave Otto | Dave Otto | Frank Viola | Derek Lilliquist | 415 | 443 | -28 |
| 1992-08-12 | @ CLE | 113 | L 5-8 | 52-61 | 5 | 11,516 | John Dopson | Jose Mesa | Eric Plunk | Daryl Irvine | Steve Olin | 420 | 451 | -31 |
| 1992-08-13 | @ CLE | 114 | W 4-2 | 53-61 | 5 | 26,797 | Roger Clemens | Charles Nagy | Roger Clemens | Charles Nagy | Jeff Reardon | 424 | 453 | -29 |
| 1992-08-14 | @ MIL | 115 | L 7-8 | 53-63 | 5 | 0 | Joe Hesketh | Chris Bosio | Jim Austin | Jeff Reardon | | 431 | 461 | -30 |
| 1992-08-14 | @ MIL | 116 | L 0-1 | 53-63 | 5 | 25,598 | Greg Harris | Cal Eldred | Cal Eldred | Greg Harris | Darren Holmes | 431 | 462 | -31 |
| 1992-08-15 | @ MIL | 117 | W 3-1 | 54-63 | 5 | 35,095 | Danny Darwin | Bill Wegman | Danny Darwin | Bill Wegman | | 434 | 463 | -29 |
| 1992-08-16 | @ MIL | 118 | L 0-1 | 54-64 | 5 | 27,174 | Frank Viola | Jaime Navarro | Jaime Navarro | Frank Viola | | 434 | 464 | -30 |
| 1992-08-18 | vs CAL | 119 | W 8-0 | 55-64 | 5 | 33,339 | Roger Clemens | Mark Langston | Roger Clemens | Mark Langston | | 442 | 464 | -22 |
| 1992-08-19 | vs CAL | 120 | L 2-3 | 55-65 | 5 | 32,980 | John Dopson | Jim Abbott | Jim Abbott | Jeff Reardon | Joe Grahe | 444 | 467 | -23 |
| 1992-08-20 | vs CAL | 121 | L 0-2 | 55-66 | 6 | 32,879 | Danny Darwin | Bert Blyleven | Bert Blyleven | Danny Darwin | Joe Grahe | 444 | 469 | -25 |
| 1992-08-21 | vs SEA | 122 | L 2-5 | 55-67 | 6 | 33,444 | Frank Viola | Randy Johnson | Randy Johnson | Frank Viola | | 446 | 474 | -28 |
| 1992-08-22 | vs SEA | 123 | W 10-8 | 56-67 | 6 | 33,275 | Joe Hesketh | Erik Hanson | Greg Harris | Shawn Barton | Jeff Reardon | 456 | 482 | -26 |
| 1992-08-23 | vs SEA | 124 | L 3-9 | 56-68 | 6 | 33,365 | Roger Clemens | Tim Leary | Dennis Powell | Roger Clemens | | 459 | 491 | -32 |
| 1992-08-24 | vs OAK | 125 | L 3-9 | 56-69 | 7 | 33,494 | John Dopson | Dave Stewart | Dave Stewart | John Dopson | | 462 | 500 | -38 |
| 1992-08-25 | vs OAK | 126 | W 5-4 | 57-69 | 7 | 33,387 | Danny Darwin | Ron Darling | Paul Quantrill | Dennis Eckersley | Jeff Reardon | 467 | 504 | -37 |
| 1992-08-26 | vs OAK | 127 | W 2-1 | 58-69 | 7 | 33,193 | Frank Viola | Kelly Downs | Frank Viola | Kevin Campbell | | 469 | 505 | -36 |
| 1992-08-28 | @ CAL | 128 | W 7-1 | 59-69 | 6 | 29,872 | Roger Clemens | Chuck Finley | Roger Clemens | Chuck Finley | | 476 | 506 | -30 |
| 1992-08-29 | @ CAL | 129 | L 2-7 | 59-70 | 6 | 24,717 | John Dopson | Mark Langston | Mark Langston | John Dopson | | 478 | 513 | -35 |
| 1992-08-30 | @ CAL | 130 | W 4-2 | 60-70 | 6 | 22,421 | Danny Darwin | Jim Abbott | Danny Darwin | Mike Butcher | Greg Harris | 482 | 515 | -33 |
| 1992-08-31 | @ SEA | 131 | L 2-15 | 60-71 | 6 | 14,017 | Frank Viola | Randy Johnson | Randy Johnson | Frank Viola | | 484 | 530 | -46 |
| 1992-09-01 | @ SEA | 132 | L 3-4 | 60-72 | 6 | 12,458 | Matt Young | Brian Fisher | Mike Schooler | Greg Harris | | 487 | 534 | -47 |
| 1992-09-02 | @ SEA | 133 | W 5-3 | 61-72 | 6 | 14,717 | Roger Clemens | Tim Leary | Roger Clemens | Tim Leary | | 492 | 537 | -45 |
| 1992-09-04 | @ OAK | 134 | W 8-3 | 62-72 | 6 | 35,084 | Danny Darwin | Dave Stewart | Danny Darwin | Dave Stewart | | 500 | 540 | -40 |
| 1992-09-05 | @ OAK | 135 | W 7-3 | 63-72 | 4 | 32,610 | John Dopson | Ron Darling | John Dopson | Ron Darling | | 507 | 543 | -36 |
| 1992-09-06 | @ OAK | 136 | L 1-2 | 63-73 | 6 | 29,670 | Frank Viola | Bobby Witt | Dennis Eckersley | Paul Quantrill | | 508 | 545 | -37 |
| 1992-09-07 | @ TEX | 137 | W 3-0 | 64-73 | 5 | 29,699 | Roger Clemens | Nolan Ryan | Roger Clemens | Nolan Ryan | Joe Hesketh | 511 | 545 | -34 |
| 1992-09-08 | @ TEX | 138 | L 1-6 | 64-74 | 5 | 13,294 | Matt Young | Kevin Brown | Kevin Brown | Matt Young | | 512 | 551 | -39 |
| 1992-09-09 | @ TEX | 139 | L 2-3 | 64-75 | 5 | 13,542 | Danny Darwin | Jose Guzman | Jose Guzman | Danny Darwin | | 514 | 554 | -40 |
| 1992-09-11 | vs DET | 140 | W 7-6 | 65-75 | 5 | 32,696 | Frank Viola | John Doherty | Mike Gardiner | John Doherty | Ken Ryan | 521 | 560 | -39 |
| 1992-09-12 | vs DET | 141 | L 5-9 | 65-76 | 7 | 32,865 | Roger Clemens | Walt Terrell | Walt Terrell | Roger Clemens | | 526 | 569 | -43 |
| 1992-09-13 | vs DET | 142 | L 2-7 | 65-77 | 7 | 32,615 | John Dopson | Frank Tanana | Frank Tanana | John Dopson | | 528 | 576 | -48 |
| 1992-09-14 | vs MIL | 143 | L 0-6 | 65-78 | 7 | 27,578 | Danny Darwin | Chris Bosio | Chris Bosio | Danny Darwin | | 528 | 582 | -54 |
| 1992-09-15 | vs MIL | 144 | L 2-7 | 65-79 | 7 | 23,757 | Frank Viola | Ricky Bones | Jim Austin | Frank Viola | | 530 | 589 | -59 |
| 1992-09-16 | vs MIL | 145 | W 2-1 | 66-79 | 7 | 24,106 | Mike Gardiner | Bill Wegman | Daryl Irvine | Doug Henry | | 532 | 590 | -58 |
| 1992-09-17 | vs MIL | 146 | L 4-10 | 66-80 | 7 | 29,515 | Roger Clemens | Jaime Navarro | Jaime Navarro | Roger Clemens | | 536 | 600 | -64 |
| 1992-09-18 | @ DET | 147 | L 3-10 | 66-81 | 7 | 14,951 | John Dopson | John Doherty | John Doherty | John Dopson | Eric King | 539 | 610 | -71 |
| 1992-09-19 | @ DET | 148 | L 2-3 | 66-82 | 7 | 18,613 | Danny Darwin | Frank Tanana | Frank Tanana | Greg Harris | | 541 | 613 | -72 |
| 1992-09-20 | @ DET | 149 | W 5-4 | 67-82 | 7 | 18,459 | Frank Viola | Bill Gullickson | Frank Viola | Bill Gullickson | Tony Fossas | 546 | 617 | -71 |
| 1992-09-21 | @ DET | 150 | L 5-6 | 67-83 | 7 | 9,558 | Mike Gardiner | Dave Haas | Mark Leiter | Daryl Irvine | | 551 | 623 | -72 |
| 1992-09-22 | vs CLE | 151 | L 2-4 | 67-84 | 7 | 24,412 | Roger Clemens | Alan Embree | Ted Power | Roger Clemens | Derek Lilliquist | 553 | 627 | -74 |
| 1992-09-23 | vs CLE | 152 | L 3-7 | 67-85 | 7 | 26,415 | Scott Taylor | Charles Nagy | Charles Nagy | Scott Taylor | | 556 | 634 | -78 |
| 1992-09-24 | vs CLE | 153 | W 6-4 | 68-85 | 7 | 28,135 | Danny Darwin | Scott Scudder | Danny Darwin | Scott Scudder | Greg Harris | 562 | 638 | -76 |
| 1992-09-26 | @ BAL | 154 | W 7-3 | 69-86 | 7 | 0 | Frank Viola | Mike Mussina | Greg Harris | Todd Frohwirth | | 569 | 641 | -72 |
| 1992-09-26 | @ BAL | 155 | L 0-2 | 69-86 | 7 | 45,454 | John Dopson | Craig Lefferts | Craig Lefferts | John Dopson | Gregg Olson | 569 | 643 | -74 |
| 1992-09-27 | @ BAL | 156 | W 6-1 | 70-86 | 7 | 45,597 | Joe Hesketh | Rick Sutcliffe | Joe Hesketh | Rick Sutcliffe | | 575 | 644 | -69 |
| 1992-09-28 | @ BAL | 157 | L 3-7 | 70-87 | 7 | 45,663 | Mike Gardiner | Arthur Rhodes | Storm Davis | Daryl Irvine | | 578 | 651 | -73 |
| 1992-09-29 | @ TOR | 158 | L 2-5 | 70-88 | 7 | 50,418 | Danny Darwin | Jimmy Key | Jimmy Key | Danny Darwin | Tom Henke | 580 | 656 | -76 |
| 1992-09-30 | @ TOR | 159 | W 1-0 | 71-88 | 7 | 50,420 | Frank Viola | David Cone | Frank Viola | David Cone | | 581 | 656 | -75 |
| 1992-10-02 | vs NYA | 160 | L 3-6 | 71-89 | 7 | 33,097 | John Dopson | Bob Wickman | Bob Wickman | John Dopson | Steve Farr | 584 | 662 | -78 |
| 1992-10-03 | vs NYA | 161 | W 7-5 | 72-89 | 7 | 33,223 | Mike Gardiner | Scott Sanderson | Scott Taylor | Scott Sanderson | | 591 | 667 | -76 |
| 1992-10-04 | vs NYA | 162 | W 8-2 | 73-89 | 7 | 33,229 | Joe Hesketh | Scott Kamieniecki | Joe Hesketh | Scott Kamieniecki | Paul Quantrill | 599 | 669 | -70 |