| 1992-04-07 | vs CHA | 1 | L 4-10 | 0-1 | 7 | 32,160 | Mark Langston | Jack McDowell | Jack McDowell | Mark Langston | Wilson Alvarez | 4 | 10 | -6 |
| 1992-04-08 | vs CHA | 2 | L 3-4 | 0-2 | 7 | 21,622 | Jim Abbott | Greg Hibbard | Greg Hibbard | Jim Abbott | Bobby Thigpen | 7 | 14 | -7 |
| 1992-04-09 | vs CHA | 3 | L 6-7 | 0-3 | 7 | 19,926 | Joe Grahe | Kirk McCaskill | Kirk McCaskill | Joe Grahe | Scott Radinsky | 13 | 21 | -8 |
| 1992-04-10 | vs MIL | 4 | L 4-5 | 0-4 | 7 | 29,338 | Scott Lewis | Ricky Bones | Dan Plesac | Bryan Harvey | Doug Henry | 17 | 26 | -9 |
| 1992-04-11 | vs MIL | 5 | W 4-1 | 1-4 | 6 | 22,679 | Don Robinson | Bill Wegman | Don Robinson | Bill Wegman | Bryan Harvey | 21 | 27 | -6 |
| 1992-04-12 | vs MIL | 6 | W 13-9 | 2-4 | 6 | 22,823 | Mark Langston | Chris Bosio | Mark Langston | Chris Bosio | | 34 | 36 | -2 |
| 1992-04-13 | @ TEX | 7 | W 3-0 | 3-4 | 5 | 41,129 | Jim Abbott | Jose Guzman | Jim Abbott | Jose Guzman | Bryan Harvey | 37 | 36 | 1 |
| 1992-04-14 | @ TEX | 8 | W 8-1 | 4-4 | 4 | 22,707 | Joe Grahe | Jeff Robinson | Joe Grahe | Jeff Robinson | | 45 | 37 | 8 |
| 1992-04-15 | @ TEX | 9 | L 2-3 | 4-5 | 5 | 16,724 | Julio Valera | Bobby Witt | Bobby Witt | Julio Valera | Jeff Russell | 47 | 40 | 7 |
| 1992-04-16 | @ TEX | 10 | W 3-2 | 5-5 | 4 | 22,686 | Don Robinson | Brian Bohanon | Chuck Crim | Jeff Russell | Bryan Harvey | 50 | 42 | 8 |
| 1992-04-17 | @ KCA | 11 | W 8-1 | 6-5 | 4 | 18,296 | Scott Lewis | Mike Boddicker | Scott Lewis | Mike Boddicker | | 58 | 43 | 15 |
| 1992-04-18 | @ KCA | 12 | W 5-3 | 7-5 | 4 | 20,129 | Jim Abbott | Tom Gordon | Steve Frey | Jeff Montgomery | | 63 | 46 | 17 |
| 1992-04-20 | @ OAK | 13 | L 3-4 | 7-6 | 4 | 24,106 | Joe Grahe | Joe Slusarski | Dennis Eckersley | Chuck Crim | | 66 | 50 | 16 |
| 1992-04-21 | @ OAK | 14 | W 3-2 | 8-6 | 4 | 22,369 | Don Robinson | Dave Stewart | Julio Valera | Dave Stewart | Bryan Harvey | 69 | 52 | 17 |
| 1992-04-22 | @ OAK | 15 | L 4-10 | 8-7 | 4 | 31,282 | Chuck Finley | Mike Moore | Mike Moore | Chuck Finley | | 73 | 62 | 11 |
| 1992-04-24 | vs SEA | 16 | L 2-7 | 8-8 | 5 | 23,434 | Jim Abbott | Dave Fleming | Dave Fleming | Jim Abbott | | 75 | 69 | 6 |
| 1992-04-25 | vs SEA | 17 | L 6-10 | 8-9 | 5 | 31,116 | Joe Grahe | Randy Johnson | Randy Johnson | Joe Grahe | Mike Schooler | 81 | 79 | 2 |
| 1992-04-26 | vs SEA | 18 | W 7-5 | 9-9 | 5 | 36,119 | Mark Langston | Erik Hanson | Scott Bailes | Jeff Nelson | Bryan Harvey | 88 | 84 | 4 |
| 1992-04-28 | @ TOR | 19 | W 9-5 | 10-9 | 4 | 46,201 | Chuck Finley | Dave Stieb | Chuck Finley | Dave Stieb | | 97 | 89 | 8 |
| 1992-04-29 | @ TOR | 20 | L 0-1 | 10-10 | 4 | 47,356 | Jim Abbott | Todd Stottlemyre | Todd Stottlemyre | Jim Abbott | | 97 | 90 | 7 |
| 1992-04-30 | @ CLE | 21 | W 8-5 | 11-10 | 4 | 4,675 | Joe Grahe | Jeff Shaw | Joe Grahe | Jeff Shaw | Bryan Harvey | 105 | 95 | 10 |
| 1992-05-01 | @ CLE | 22 | W 7-5 | 12-10 | 4 | 9,367 | Mark Langston | Scott Scudder | Mark Langston | Scott Scudder | Bryan Harvey | 112 | 100 | 12 |
| 1992-05-02 | @ CLE | 23 | L 2-3 | 12-11 | 4 | 6,544 | Julio Valera | Dennis Cook | Derek Lilliquist | Mark Eichhorn | Steve Olin | 114 | 103 | 11 |
| 1992-05-03 | @ CLE | 24 | W 6-3 | 13-11 | 4 | 8,797 | Chuck Finley | Charles Nagy | Scott Bailes | Derek Lilliquist | Bryan Harvey | 120 | 106 | 14 |
| 1992-05-04 | @ DET | 25 | L 2-6 | 13-12 | 4 | 9,466 | Jim Abbott | Bill Gullickson | Bill Gullickson | Jim Abbott | | 122 | 112 | 10 |
| 1992-05-05 | @ DET | 26 | L 1-2 | 13-13 | 4 | 13,180 | Joe Grahe | Scott Aldred | John Doherty | Mark Eichhorn | | 123 | 114 | 9 |
| 1992-05-06 | vs NYA | 27 | W 3-2 | 14-13 | 4 | 23,079 | Mark Langston | Melido Perez | Mark Langston | Melido Perez | Bryan Harvey | 126 | 116 | 10 |
| 1992-05-07 | vs NYA | 28 | W 6-0 | 15-13 | 3 | 22,552 | Julio Valera | Scott Sanderson | Julio Valera | Scott Sanderson | | 132 | 116 | 16 |
| 1992-05-08 | vs TOR | 29 | W 4-1 | 16-13 | 3 | 36,383 | Chuck Finley | Dave Stieb | Mark Eichhorn | Dave Stieb | | 136 | 117 | 19 |
| 1992-05-09 | vs TOR | 30 | W 2-1 | 17-13 | 3 | 36,159 | Jim Abbott | Todd Stottlemyre | Jim Abbott | Todd Stottlemyre | Bryan Harvey | 138 | 118 | 20 |
| 1992-05-10 | vs TOR | 31 | L 1-4 | 17-14 | 3 | 23,009 | Joe Grahe | Juan Guzman | Juan Guzman | Joe Grahe | | 139 | 122 | 17 |
| 1992-05-12 | vs DET | 32 | L 2-4 | 17-15 | 3 | 21,500 | Mark Langston | Mark Leiter | Frank Tanana | Bryan Harvey | Mike Henneman | 141 | 126 | 15 |
| 1992-05-13 | vs DET | 33 | W 7-5 | 18-15 | 3 | 28,331 | Chuck Finley | Eric King | Steve Frey | Walt Terrell | Bryan Harvey | 148 | 131 | 17 |
| 1992-05-15 | @ BOS | 34 | L 0-3 | 18-16 | 3 | 33,254 | Jim Abbott | Roger Clemens | Roger Clemens | Jim Abbott | | 148 | 134 | 14 |
| 1992-05-16 | @ BOS | 35 | L 0-3 | 18-17 | 4 | 33,247 | Julio Valera | Frank Viola | Frank Viola | Julio Valera | Jeff Reardon | 148 | 137 | 11 |
| 1992-05-17 | @ BOS | 36 | W 3-1 | 19-17 | 4 | 32,554 | Mark Langston | John Dopson | Mark Langston | John Dopson | Bryan Harvey | 151 | 138 | 13 |
| 1992-05-18 | @ NYA | 37 | L 2-7 | 19-18 | 4 | 13,250 | Chuck Finley | Greg Cadaret | Greg Cadaret | Chuck Finley | Steve Howe | 153 | 145 | 8 |
| 1992-05-19 | @ NYA | 38 | L 4-5 | 19-19 | 5 | 14,919 | Bert Blyleven | Scott Sanderson | Rich Monteleone | Mark Eichhorn | | 157 | 150 | 7 |
| 1992-05-20 | @ NYA | 39 | L 2-3 | 19-20 | 5 | 15,800 | Jim Abbott | Scott Kamieniecki | John Habyan | Chuck Crim | | 159 | 153 | 6 |
| 1992-05-22 | @ BAL | 40 | L 3-5 | 19-21 | 5 | 45,709 | Julio Valera | Ben McDonald | Ben McDonald | Julio Valera | Gregg Olson | 162 | 158 | 4 |
| 1992-05-23 | @ BAL | 41 | W 6-2 | 20-21 | 5 | 41,146 | Mark Langston | Rick Sutcliffe | Mark Langston | Rick Sutcliffe | | 168 | 160 | 8 |
| 1992-05-24 | @ BAL | 42 | L 4-6 | 20-22 | 5 | 42,721 | Chuck Finley | Bob Milacki | Bob Milacki | Chuck Finley | Gregg Olson | 172 | 166 | 6 |
| 1992-05-26 | vs BOS | 43 | L 1-4 | 20-23 | 5 | 23,649 | Jim Abbott | Roger Clemens | Roger Clemens | Jim Abbott | Jeff Reardon | 173 | 170 | 3 |
| 1992-05-27 | vs BOS | 44 | L 3-4 | 20-24 | 5 | 23,127 | Julio Valera | Frank Viola | Jeff Reardon | Bryan Harvey | Danny Darwin | 176 | 174 | 2 |
| 1992-05-28 | vs BOS | 45 | L 1-2 | 20-25 | 5 | 23,843 | Mark Langston | Joe Hesketh | Joe Hesketh | Mark Langston | Jeff Reardon | 177 | 176 | 1 |
| 1992-05-29 | vs CLE | 46 | L 2-14 | 20-26 | 5 | 22,322 | Chuck Finley | Denis Boucher | Denis Boucher | Chuck Finley | | 179 | 190 | -11 |
| 1992-05-30 | vs CLE | 47 | W 3-1 | 21-26 | 5 | 37,322 | Bert Blyleven | Jack Armstrong | Bert Blyleven | Jack Armstrong | Bryan Harvey | 182 | 191 | -9 |
| 1992-05-31 | vs CLE | 48 | L 3-4 | 21-27 | 5 | 40,167 | Jim Abbott | Charles Nagy | Charles Nagy | Jim Abbott | Steve Olin | 185 | 195 | -10 |
| 1992-06-01 | vs BAL | 49 | L 2-8 | 21-28 | 6 | 23,560 | Julio Valera | Ben McDonald | Ben McDonald | Julio Valera | Storm Davis | 187 | 203 | -16 |
| 1992-06-02 | vs BAL | 50 | L 2-4 | 21-29 | 6 | 20,064 | Mark Langston | Mike Mussina | Mike Mussina | Mark Langston | Gregg Olson | 189 | 207 | -18 |
| 1992-06-03 | vs BAL | 51 | W 4-3 | 22-29 | 5 | 20,065 | Chuck Finley | Bob Milacki | Scott Bailes | Alan Mills | | 193 | 210 | -17 |
| 1992-06-05 | @ MIL | 52 | L 1-7 | 22-30 | 5 | 14,155 | Jim Abbott | Chris Bosio | Chris Bosio | Jim Abbott | | 194 | 217 | -23 |
| 1992-06-06 | @ MIL | 53 | L 3-4 | 22-31 | 5 | 26,543 | Bert Blyleven | Jaime Navarro | Jaime Navarro | Bryan Harvey | Doug Henry | 197 | 221 | -24 |
| 1992-06-07 | @ MIL | 54 | L 3-10 | 22-32 | 6 | 22,890 | Mark Langston | Ricky Bones | Ricky Bones | Mark Langston | | 200 | 231 | -31 |
| 1992-06-08 | @ CHA | 55 | L 1-5 | 22-33 | 6 | 30,483 | Chuck Finley | Jack McDowell | Jack McDowell | Chuck Finley | Bobby Thigpen | 201 | 236 | -35 |
| 1992-06-09 | @ CHA | 56 | L 2-4 | 22-34 | 7 | 29,906 | Julio Valera | Greg Hibbard | Greg Hibbard | Julio Valera | Scott Radinsky | 203 | 240 | -37 |
| 1992-06-10 | @ CHA | 57 | L 2-3 | 22-35 | 7 | 26,483 | Jim Abbott | Kirk McCaskill | Donn Pall | Steve Frey | | 205 | 243 | -38 |
| 1992-06-11 | @ CHA | 58 | W 4-0 | 23-35 | 7 | 33,058 | Bert Blyleven | Alex Fernandez | Bert Blyleven | Alex Fernandez | Joe Grahe | 209 | 243 | -34 |
| 1992-06-12 | vs KCA | 59 | W 5-0 | 24-35 | 7 | 40,407 | Mark Langston | Hipolito Pichardo | Mark Langston | Hipolito Pichardo | | 214 | 243 | -29 |
| 1992-06-13 | vs KCA | 60 | W 5-4 | 25-35 | 5 | 26,635 | Chuck Finley | Rick Reed | Chuck Finley | Rick Reed | Mark Eichhorn | 219 | 247 | -28 |
| 1992-06-14 | vs KCA | 61 | W 5-1 | 26-35 | 5 | 39,902 | Julio Valera | Mark Gubicza | Julio Valera | Mark Gubicza | Steve Frey | 224 | 248 | -24 |
| 1992-06-15 | vs TEX | 62 | L 2-5 | 26-36 | 5 | 19,127 | Jim Abbott | Todd Burns | Todd Burns | Jim Abbott | Jeff Russell | 226 | 253 | -27 |
| 1992-06-16 | vs TEX | 63 | W 4-1 | 27-36 | 5 | 51,401 | Bert Blyleven | Jose Guzman | Bert Blyleven | Jose Guzman | Joe Grahe | 230 | 254 | -24 |
| 1992-06-17 | vs TEX | 64 | W 3-0 | 28-36 | 5 | 37,135 | Mark Langston | Nolan Ryan | Mark Langston | Nolan Ryan | | 233 | 254 | -21 |
| 1992-06-19 | vs OAK | 65 | L 8-12 | 28-37 | 6 | 30,513 | Chuck Finley | Dave Stewart | Dave Stewart | Chuck Finley | Dennis Eckersley | 241 | 266 | -25 |
| 1992-06-20 | vs OAK | 66 | W 10-0 | 29-37 | 5 | 26,344 | Julio Valera | Bob Welch | Julio Valera | Bob Welch | | 251 | 266 | -15 |
| 1992-06-21 | vs OAK | 67 | W 4-2 | 30-37 | 5 | 38,505 | Jim Abbott | Mike Moore | Jim Abbott | Mike Moore | Joe Grahe | 255 | 268 | -13 |
| 1992-06-22 | @ MIN | 68 | L 0-2 | 30-38 | 5 | 22,936 | Mark Langston | John Smiley | John Smiley | Mark Langston | Rick Aguilera | 255 | 270 | -15 |
| 1992-06-23 | @ MIN | 69 | L 3-5 | 30-39 | 5 | 31,494 | Bert Blyleven | Scott Erickson | Scott Erickson | Bert Blyleven | Rick Aguilera | 258 | 275 | -17 |
| 1992-06-24 | @ MIN | 70 | L 0-11 | 30-40 | 5 | 30,933 | Chuck Finley | Kevin Tapani | Kevin Tapani | Chuck Finley | | 258 | 286 | -28 |
| 1992-06-25 | @ SEA | 71 | L 4-13 | 30-41 | 5 | 14,219 | Julio Valera | Rich DeLucia | Rich DeLucia | Julio Valera | | 262 | 299 | -37 |
| 1992-06-26 | @ SEA | 72 | W 10-1 | 31-41 | 5 | 17,564 | Jim Abbott | Mike Walker | Jim Abbott | Mike Walker | | 272 | 300 | -28 |
| 1992-06-27 | @ SEA | 73 | W 2-1 | 32-41 | 5 | 29,171 | Mark Langston | Randy Johnson | Mark Langston | Randy Johnson | | 274 | 301 | -27 |
| 1992-06-28 | @ SEA | 74 | L 2-9 | 32-42 | 5 | 14,335 | Bert Blyleven | Erik Hanson | Erik Hanson | Bert Blyleven | | 276 | 310 | -34 |
| 1992-06-29 | vs MIN | 75 | L 1-5 | 32-43 | 6 | 21,656 | Chuck Finley | Kevin Tapani | Kevin Tapani | Chuck Finley | | 277 | 315 | -38 |
| 1992-06-30 | vs MIN | 76 | L 0-2 | 32-44 | 6 | 23,045 | Julio Valera | Bill Krueger | Bill Krueger | Julio Valera | | 277 | 317 | -40 |
| 1992-07-01 | vs MIN | 77 | L 1-2 | 32-45 | 6 | 25,629 | Jim Abbott | Willie Banks | Willie Banks | Jim Abbott | Rick Aguilera | 278 | 319 | -41 |
| 1992-07-03 | @ TOR | 78 | L 1-10 | 32-46 | 6 | 50,408 | Mark Langston | Jimmy Key | Jimmy Key | Mark Langston | | 279 | 329 | -50 |
| 1992-07-04 | @ TOR | 79 | L 6-8 | 32-47 | 7 | 50,418 | Bert Blyleven | Jack Morris | Jack Morris | Mark Eichhorn | Tom Henke | 285 | 337 | -52 |
| 1992-07-05 | @ TOR | 80 | L 2-6 | 32-48 | 7 | 50,398 | Julio Valera | David Wells | David Wells | Julio Valera | | 287 | 343 | -56 |
| 1992-07-06 | @ TOR | 81 | L 0-3 | 32-49 | 7 | 50,406 | Jim Abbott | Juan Guzman | Juan Guzman | Jim Abbott | Tom Henke | 287 | 346 | -59 |
| 1992-07-07 | @ CLE | 82 | L 1-3 | 32-50 | 7 | 9,796 | Chuck Finley | Dennis Cook | Dennis Cook | Chuck Finley | Steve Olin | 288 | 349 | -61 |
| 1992-07-08 | @ CLE | 83 | L 4-8 | 32-51 | 7 | 7,195 | Mark Langston | Charles Nagy | Charles Nagy | Mark Langston | | 292 | 357 | -65 |
| 1992-07-09 | @ DET | 84 | L 4-5 | 32-52 | 7 | 15,102 | Bert Blyleven | Frank Tanana | Frank Tanana | Bert Blyleven | Mike Henneman | 296 | 362 | -66 |
| 1992-07-10 | @ DET | 85 | W 6-1 | 33-52 | 7 | 19,211 | Julio Valera | Buddy Groom | Julio Valera | Buddy Groom | | 302 | 363 | -61 |
| 1992-07-11 | @ DET | 86 | W 2-1 | 34-52 | 7 | 39,461 | Jim Abbott | Bill Gullickson | Chuck Crim | Bill Gullickson | Joe Grahe | 304 | 364 | -60 |
| 1992-07-12 | @ DET | 87 | W 5-4 | 35-52 | 7 | 22,395 | Chuck Finley | Kevin Ritz | Steve Frey | Mike Henneman | | 309 | 368 | -59 |
| 1992-07-16 | vs NYA | 88 | W 3-2 | 36-52 | 6 | 31,256 | Julio Valera | Melido Perez | Steve Frey | Melido Perez | | 312 | 370 | -58 |
| 1992-07-17 | vs NYA | 89 | W 12-4 | 37-52 | 6 | 31,410 | Chuck Finley | Scott Sanderson | Chuck Crim | Scott Sanderson | Joe Grahe | 324 | 374 | -50 |
| 1992-07-18 | vs NYA | 90 | W 5-3 | 38-52 | 6 | 31,368 | Mark Langston | Scott Kamieniecki | Mark Langston | Scott Kamieniecki | Mark Eichhorn | 329 | 377 | -48 |
| 1992-07-19 | vs NYA | 91 | L 3-8 | 38-53 | 6 | 24,084 | Bert Blyleven | Curt Young | Curt Young | Bert Blyleven | | 332 | 385 | -53 |
| 1992-07-20 | vs TOR | 92 | W 5-3 | 39-53 | 6 | 21,090 | Tim Fortugno | Todd Stottlemyre | Chuck Crim | Pat Hentgen | Joe Grahe | 337 | 388 | -51 |
| 1992-07-21 | vs TOR | 93 | L 5-9 | 39-54 | 6 | 21,581 | Julio Valera | Jack Morris | Jack Morris | Chuck Crim | Duane Ward | 342 | 397 | -55 |
| 1992-07-22 | vs TOR | 94 | W 5-4 | 40-54 | 6 | 22,178 | Chuck Finley | Jimmy Key | Joe Grahe | Jimmy Key | | 347 | 401 | -54 |
| 1992-07-23 | vs DET | 95 | L 2-5 | 40-55 | 6 | 20,900 | Mark Langston | Mark Leiter | Mark Leiter | Mark Langston | John Doherty | 349 | 406 | -57 |
| 1992-07-24 | vs DET | 96 | W 6-3 | 41-55 | 6 | 22,951 | Bert Blyleven | Kevin Ritz | Bert Blyleven | Kevin Ritz | Joe Grahe | 355 | 409 | -54 |
| 1992-07-25 | vs DET | 97 | W 9-0 | 42-55 | 6 | 30,682 | Tim Fortugno | Walt Terrell | Tim Fortugno | Walt Terrell | | 364 | 409 | -45 |
| 1992-07-26 | vs DET | 98 | W 4-3 | 43-55 | 6 | 30,549 | Julio Valera | Frank Tanana | Chuck Crim | John Doherty | Joe Grahe | 368 | 412 | -44 |
| 1992-07-27 | vs SEA | 99 | W 3-0 | 44-55 | 5 | 19,658 | Chuck Finley | Erik Hanson | Chuck Finley | Erik Hanson | Joe Grahe | 371 | 412 | -41 |
| 1992-07-28 | vs SEA | 100 | L 1-8 | 44-56 | 5 | 19,509 | Mark Langston | Dave Fleming | Dave Fleming | Mark Langston | | 372 | 420 | -48 |
| 1992-07-29 | vs SEA | 101 | L 0-8 | 44-57 | 6 | 19,896 | Bert Blyleven | Brian Fisher | Brian Fisher | Bert Blyleven | | 372 | 428 | -56 |
| 1992-07-30 | vs SEA | 102 | W 6-5 | 45-57 | 5 | 23,546 | Tim Fortugno | Mark Grant | Mark Eichhorn | Russ Swan | Joe Grahe | 378 | 433 | -55 |
| 1992-07-31 | @ TEX | 103 | W 5-3 | 46-57 | 5 | 32,524 | Julio Valera | Bobby Witt | Chuck Crim | Bobby Witt | Joe Grahe | 383 | 436 | -53 |
| 1992-08-01 | @ TEX | 104 | W 6-1 | 47-57 | 5 | 36,933 | Chuck Finley | Nolan Ryan | Chuck Finley | Nolan Ryan | | 389 | 437 | -48 |
| 1992-08-02 | @ TEX | 105 | L 1-5 | 47-58 | 5 | 24,927 | Mark Langston | Kevin Brown | Kevin Brown | Mark Langston | | 390 | 442 | -52 |
| 1992-08-04 | @ KCA | 106 | W 5-1 | 48-59 | 5 | 0 | Bert Blyleven | Kevin Appier | Bert Blyleven | Kevin Appier | Chuck Crim | 395 | 443 | -48 |
| 1992-08-04 | @ KCA | 107 | L 1-4 | 48-59 | 5 | 25,576 | Tim Fortugno | Luis Aquino | Luis Aquino | Tim Fortugno | | 396 | 447 | -51 |
| 1992-08-05 | @ KCA | 108 | L 2-5 | 48-60 | 6 | 24,300 | Julio Valera | Rick Reed | Tom Gordon | Julio Valera | Jeff Montgomery | 398 | 452 | -54 |
| 1992-08-06 | @ KCA | 109 | L 6-7 | 48-61 | 6 | 22,553 | Chuck Finley | Hipolito Pichardo | Juan Berenguer | Chuck Crim | Jeff Montgomery | 404 | 459 | -55 |
| 1992-08-07 | vs CHA | 110 | W 3-1 | 49-61 | 6 | 26,555 | Mark Langston | Jack McDowell | Mark Langston | Jack McDowell | Joe Grahe | 407 | 460 | -53 |
| 1992-08-08 | vs CHA | 111 | L 2-8 | 49-62 | 6 | 29,349 | Jim Abbott | Greg Hibbard | Roberto Hernandez | Steve Frey | | 409 | 468 | -59 |
| 1992-08-09 | vs CHA | 112 | L 8-12 | 49-63 | 6 | 25,401 | Bert Blyleven | Alex Fernandez | Donn Pall | Scott Bailes | | 417 | 480 | -63 |
| 1992-08-10 | vs MIL | 113 | W 4-1 | 50-63 | 6 | 20,093 | Julio Valera | Bill Wegman | Julio Valera | Bill Wegman | | 421 | 481 | -60 |
| 1992-08-11 | vs MIL | 114 | W 1-0 | 51-63 | 6 | 21,142 | Chuck Finley | Jaime Navarro | Joe Grahe | Jaime Navarro | | 422 | 481 | -59 |
| 1992-08-12 | vs MIL | 115 | W 2-1 | 52-63 | 5 | 23,338 | Mark Langston | Bruce Ruffin | Mark Langston | Bruce Ruffin | Joe Grahe | 424 | 482 | -58 |
| 1992-08-13 | @ OAK | 116 | L 1-4 | 52-64 | 5 | 24,650 | Jim Abbott | Mike Moore | Mike Moore | Jim Abbott | | 425 | 486 | -61 |
| 1992-08-14 | @ OAK | 117 | W 2-1 | 53-64 | 5 | 28,882 | Bert Blyleven | Dave Stewart | Bert Blyleven | Dave Stewart | Joe Grahe | 427 | 487 | -60 |
| 1992-08-15 | @ OAK | 118 | L 5-9 | 53-65 | 5 | 33,149 | Julio Valera | Ron Darling | Jim Corsi | Chuck Crim | | 432 | 496 | -64 |
| 1992-08-16 | @ OAK | 119 | L 4-5 | 53-66 | 6 | 32,003 | Chuck Finley | Kelly Downs | Dennis Eckersley | Joe Grahe | | 436 | 501 | -65 |
| 1992-08-18 | @ BOS | 120 | L 0-8 | 53-67 | 6 | 33,339 | Mark Langston | Roger Clemens | Roger Clemens | Mark Langston | | 436 | 509 | -73 |
| 1992-08-19 | @ BOS | 121 | W 3-2 | 54-67 | 6 | 32,980 | Jim Abbott | John Dopson | Jim Abbott | Jeff Reardon | Joe Grahe | 439 | 511 | -72 |
| 1992-08-20 | @ BOS | 122 | W 2-0 | 55-67 | 6 | 32,879 | Bert Blyleven | Danny Darwin | Bert Blyleven | Danny Darwin | Joe Grahe | 441 | 511 | -70 |
| 1992-08-21 | @ NYA | 123 | W 9-5 | 56-67 | 6 | 22,631 | Julio Valera | Shawn Hillegas | Mike Butcher | Shawn Hillegas | Tim Fortugno | 450 | 516 | -66 |
| 1992-08-22 | @ NYA | 124 | L 0-3 | 56-68 | 6 | 25,717 | Chuck Finley | Melido Perez | Melido Perez | Chuck Finley | Steve Farr | 450 | 519 | -69 |
| 1992-08-23 | @ NYA | 125 | W 7-3 | 57-68 | 5 | 28,589 | Mark Langston | Scott Sanderson | Mike Butcher | Rich Monteleone | | 457 | 522 | -65 |
| 1992-08-24 | @ BAL | 126 | W 5-2 | 58-68 | 5 | 44,285 | Jim Abbott | Arthur Rhodes | Jim Abbott | Arthur Rhodes | Joe Grahe | 462 | 524 | -62 |
| 1992-08-25 | @ BAL | 127 | L 1-9 | 58-69 | 5 | 44,915 | Bert Blyleven | Rick Sutcliffe | Rick Sutcliffe | Bert Blyleven | | 463 | 533 | -70 |
| 1992-08-26 | @ BAL | 128 | L 4-6 | 58-70 | 5 | 46,023 | Julio Valera | Mike Mussina | Todd Frohwirth | Mike Butcher | Gregg Olson | 467 | 539 | -72 |
| 1992-08-28 | vs BOS | 129 | L 1-7 | 58-71 | 5 | 29,872 | Chuck Finley | Roger Clemens | Roger Clemens | Chuck Finley | | 468 | 546 | -78 |
| 1992-08-29 | vs BOS | 130 | W 7-2 | 59-71 | 5 | 24,717 | Mark Langston | John Dopson | Mark Langston | John Dopson | | 475 | 548 | -73 |
| 1992-08-30 | vs BOS | 131 | L 2-4 | 59-72 | 5 | 22,421 | Jim Abbott | Danny Darwin | Danny Darwin | Mike Butcher | Greg Harris | 477 | 552 | -75 |
| 1992-08-31 | vs CLE | 132 | L 3-4 | 59-73 | 6 | 18,013 | Bert Blyleven | Rod Nichols | Rod Nichols | Bert Blyleven | Eric Plunk | 480 | 556 | -76 |
| 1992-09-01 | vs CLE | 133 | W 7-6 | 60-73 | 6 | 17,586 | Tim Fortugno | Dennis Cook | Chuck Crim | Eric Plunk | Joe Grahe | 487 | 562 | -75 |
| 1992-09-02 | vs CLE | 134 | W 3-2 | 61-73 | 5 | 18,141 | Chuck Finley | Jack Armstrong | Scott Lewis | Derek Lilliquist | | 490 | 564 | -74 |
| 1992-09-04 | vs BAL | 135 | L 7-8 | 61-74 | 5 | 20,621 | Mark Langston | Rick Sutcliffe | Rick Sutcliffe | Mark Langston | Todd Frohwirth | 497 | 572 | -75 |
| 1992-09-05 | vs BAL | 136 | L 1-4 | 61-75 | 5 | 22,386 | Jim Abbott | Mike Mussina | Mike Mussina | Jim Abbott | Gregg Olson | 498 | 576 | -78 |
| 1992-09-06 | vs BAL | 137 | W 5-2 | 62-75 | 5 | 19,476 | Bert Blyleven | Craig Lefferts | Bert Blyleven | Craig Lefferts | Joe Grahe | 503 | 578 | -75 |
| 1992-09-07 | vs OAK | 138 | W 3-2 | 63-75 | 5 | 21,251 | Julio Valera | Mike Moore | Julio Valera | Mike Moore | Joe Grahe | 506 | 580 | -74 |
| 1992-09-08 | vs OAK | 139 | L 2-14 | 63-76 | 5 | 18,904 | Chuck Finley | Kelly Downs | Kelly Downs | Chuck Finley | | 508 | 594 | -86 |
| 1992-09-09 | vs OAK | 140 | L 0-3 | 63-77 | 5 | 21,795 | Mark Langston | Dave Stewart | Dave Stewart | Mark Langston | Dennis Eckersley | 508 | 597 | -89 |
| 1992-09-11 | @ MIN | 141 | W 8-0 | 64-77 | 5 | 23,506 | Jim Abbott | John Smiley | Jim Abbott | John Smiley | | 516 | 597 | -81 |
| 1992-09-12 | @ MIN | 142 | L 2-7 | 64-78 | 5 | 24,210 | Bert Blyleven | Mike Trombley | Mike Trombley | Bert Blyleven | Mark Guthrie | 518 | 604 | -86 |
| 1992-09-13 | @ MIN | 143 | L 2-6 | 64-79 | 5 | 23,039 | Julio Valera | Scott Erickson | Scott Erickson | Julio Valera | | 520 | 610 | -90 |
| 1992-09-15 | @ SEA | 144 | W 9-0 | 65-79 | 5 | 10,999 | Chuck Finley | Dave Fleming | Chuck Finley | Dave Fleming | | 529 | 610 | -81 |
| 1992-09-16 | @ SEA | 145 | W 2-1 | 66-79 | 5 | 11,532 | Mark Langston | Randy Johnson | Joe Grahe | Calvin Jones | Steve Frey | 531 | 611 | -80 |
| 1992-09-17 | vs MIN | 146 | L 1-2 | 66-80 | 5 | 21,566 | Jim Abbott | Mike Trombley | Mike Trombley | Jim Abbott | Rick Aguilera | 532 | 613 | -81 |
| 1992-09-18 | vs MIN | 147 | L 1-4 | 66-81 | 5 | 35,844 | Bert Blyleven | Scott Erickson | Scott Erickson | Bert Blyleven | Rick Aguilera | 533 | 617 | -84 |
| 1992-09-19 | vs MIN | 148 | W 5-1 | 67-81 | 5 | 29,131 | Julio Valera | Kevin Tapani | Julio Valera | Kevin Tapani | | 538 | 618 | -80 |
| 1992-09-20 | vs MIN | 149 | L 5-7 | 67-82 | 5 | 20,685 | Chuck Finley | Pat Mahomes | Rick Aguilera | Joe Grahe | | 543 | 625 | -82 |
| 1992-09-22 | @ MIL | 150 | L 2-3 | 67-83 | 6 | 8,692 | Mark Langston | Jaime Navarro | Dan Plesac | Mark Langston | Darren Holmes | 545 | 628 | -83 |
| 1992-09-23 | @ MIL | 151 | L 0-3 | 67-84 | 6 | 12,142 | Jim Abbott | Cal Eldred | Cal Eldred | Jim Abbott | | 545 | 631 | -86 |
| 1992-09-24 | @ MIL | 152 | L 0-4 | 67-85 | 6 | 11,541 | Bert Blyleven | Chris Bosio | Chris Bosio | Bert Blyleven | | 545 | 635 | -90 |
| 1992-09-25 | @ CHA | 153 | L 5-6 | 67-86 | 6 | 30,776 | Julio Valera | Wilson Alvarez | Roberto Hernandez | Joe Grahe | | 550 | 641 | -91 |
| 1992-09-26 | @ CHA | 154 | W 1-0 | 68-86 | 6 | 36,207 | Chuck Finley | Alex Fernandez | Chuck Finley | Alex Fernandez | Steve Frey | 551 | 641 | -90 |
| 1992-09-27 | @ CHA | 155 | L 2-3 | 68-87 | 6 | 30,865 | Mark Langston | Charlie Hough | Roberto Hernandez | Chuck Crim | | 553 | 644 | -91 |
| 1992-09-28 | vs KCA | 156 | W 6-5 | 69-87 | 6 | 19,916 | Jim Abbott | Hipolito Pichardo | Scott Lewis | Steve Shifflett | | 559 | 649 | -90 |
| 1992-09-29 | vs KCA | 157 | L 0-2 | 69-88 | 6 | 17,440 | Bert Blyleven | Dennis Rasmussen | Dennis Rasmussen | Bert Blyleven | | 559 | 651 | -92 |
| 1992-09-30 | vs KCA | 158 | L 0-4 | 69-89 | 6 | 17,336 | Julio Valera | Rick Reed | Rick Reed | Julio Valera | | 559 | 655 | -96 |
| 1992-10-01 | vs KCA | 159 | W 5-2 | 70-89 | 6 | 16,867 | Chuck Finley | Bill Sampen | Chuck Finley | Bill Sampen | Steve Frey | 564 | 657 | -93 |
| 1992-10-02 | vs TEX | 160 | W 6-3 | 71-89 | 6 | 18,526 | Mark Langston | Scott Chiamparino | Mark Langston | Scott Chiamparino | | 570 | 660 | -90 |
| 1992-10-03 | vs TEX | 161 | W 4-2 | 72-89 | 6 | 29,770 | Hilly Hathaway | Dan Smith | Scott Lewis | Dan Smith | Joe Grahe | 574 | 662 | -88 |
| 1992-10-04 | vs TEX | 162 | L 5-9 | 72-90 | 6 | 21,986 | Bert Blyleven | Kevin Brown | Kevin Brown | Bert Blyleven | | 579 | 671 | -92 |