| 1992-04-06 | @ DET | 1 | W 4-2 | 1-0 | 2 | 51,068 | Jack Morris | Bill Gullickson | Jack Morris | Bill Gullickson | | 4 | 2 | 2 |
| 1992-04-08 | @ DET | 2 | W 10-9 | 2-0 | 2 | 12,819 | Todd Stottlemyre | Frank Tanana | Tom Henke | Frank Tanana | Duane Ward | 14 | 11 | 3 |
| 1992-04-09 | @ DET | 3 | W 3-1 | 3-0 | 2 | 9,720 | Juan Guzman | Walt Terrell | Juan Guzman | Walt Terrell | Duane Ward | 17 | 12 | 5 |
| 1992-04-10 | vs BAL | 4 | W 4-3 | 4-0 | 2 | 50,424 | Jimmy Key | Mike Mussina | Pat Hentgen | Gregg Olson | | 21 | 15 | 6 |
| 1992-04-11 | vs BAL | 5 | W 7-2 | 5-0 | 2 | 50,375 | Jack Morris | Rick Sutcliffe | Jack Morris | Rick Sutcliffe | | 28 | 17 | 11 |
| 1992-04-12 | vs BAL | 6 | W 3-1 | 6-0 | 2 | 48,309 | David Wells | Jose Mesa | David Wells | Jose Mesa | Duane Ward | 31 | 18 | 13 |
| 1992-04-13 | vs NYA | 7 | L 2-5 | 6-1 | 2 | 44,115 | Todd Stottlemyre | Greg Cadaret | Steve Howe | Todd Stottlemyre | Steve Farr | 33 | 23 | 10 |
| 1992-04-14 | vs NYA | 8 | W 12-6 | 7-1 | 1 | 45,579 | Juan Guzman | Jeff Johnson | Juan Guzman | Jeff Johnson | | 45 | 29 | 16 |
| 1992-04-15 | vs NYA | 9 | W 2-0 | 8-1 | 1 | 48,111 | Jimmy Key | Melido Perez | Jimmy Key | Melido Perez | Tom Henke | 47 | 29 | 18 |
| 1992-04-16 | vs NYA | 10 | W 7-6 | 9-1 | 1 | 50,376 | Jack Morris | Tim Leary | Duane Ward | Steve Farr | | 54 | 35 | 19 |
| 1992-04-17 | @ BOS | 11 | L 0-1 | 9-2 | 1 | 27,467 | David Wells | Roger Clemens | Roger Clemens | David Wells | Jeff Reardon | 54 | 36 | 18 |
| 1992-04-18 | @ BOS | 12 | W 2-1 | 10-2 | 1 | 32,640 | Todd Stottlemyre | Frank Viola | Todd Stottlemyre | Frank Viola | Tom Henke | 56 | 37 | 19 |
| 1992-04-19 | @ BOS | 13 | L 4-5 | 10-3 | 1 | 28,196 | Juan Guzman | Matt Young | Danny Darwin | Tom Henke | | 60 | 42 | 18 |
| 1992-04-20 | @ BOS | 14 | W 6-4 | 11-3 | 1 | 34,709 | Jimmy Key | Joe Hesketh | Bob Macdonald | Tom Bolton | | 66 | 46 | 20 |
| 1992-04-21 | vs CLE | 15 | W 2-1 | 12-3 | 1 | 40,191 | Jack Morris | Dennis Cook | Jack Morris | Dennis Cook | | 68 | 47 | 21 |
| 1992-04-22 | vs CLE | 16 | L 2-7 | 12-4 | 1 | 43,292 | Dave Stieb | Charles Nagy | Charles Nagy | Dave Stieb | Ted Power | 70 | 54 | 16 |
| 1992-04-23 | vs CLE | 17 | W 13-8 | 13-4 | 1 | 42,401 | Todd Stottlemyre | Dave Otto | Todd Stottlemyre | Dave Otto | | 83 | 62 | 21 |
| 1992-04-24 | vs KCA | 18 | W 4-3 | 14-4 | 1 | 50,352 | Juan Guzman | Tom Gordon | Juan Guzman | Tom Gordon | Tom Henke | 87 | 65 | 22 |
| 1992-04-25 | vs KCA | 19 | W 6-4 | 15-4 | 1 | 50,346 | Jimmy Key | Mike Magnante | Pat Hentgen | Curt Young | Duane Ward | 93 | 69 | 24 |
| 1992-04-26 | vs KCA | 20 | L 0-9 | 15-5 | 1 | 46,486 | Jack Morris | Mark Gubicza | Mark Gubicza | Jack Morris | | 93 | 78 | 15 |
| 1992-04-28 | vs CAL | 21 | L 5-9 | 15-6 | 1 | 46,201 | Dave Stieb | Chuck Finley | Chuck Finley | Dave Stieb | | 98 | 87 | 11 |
| 1992-04-29 | vs CAL | 22 | W 1-0 | 16-6 | 1 | 47,356 | Todd Stottlemyre | Jim Abbott | Todd Stottlemyre | Jim Abbott | | 99 | 87 | 12 |
| 1992-04-30 | @ MIL | 23 | L 2-3 | 16-7 | 1 | 8,877 | Juan Guzman | Chris Bosio | Chris Bosio | Duane Ward | Doug Henry | 101 | 90 | 11 |
| 1992-05-01 | @ MIL | 24 | L 3-4 | 16-8 | 1 | 13,794 | Jimmy Key | Jaime Navarro | Jaime Navarro | Jimmy Key | Doug Henry | 104 | 94 | 10 |
| 1992-05-02 | @ MIL | 25 | L 4-5 | 16-9 | 2 | 26,547 | Jack Morris | Dan Plesac | Mike Fetters | Jack Morris | Doug Henry | 108 | 99 | 9 |
| 1992-05-03 | @ MIL | 26 | W 4-1 | 17-9 | 2 | 17,312 | Dave Stieb | Bill Wegman | Dave Stieb | Bill Wegman | | 112 | 100 | 12 |
| 1992-05-04 | @ OAK | 27 | W 7-3 | 18-9 | 2 | 20,137 | Todd Stottlemyre | Ron Darling | Todd Stottlemyre | Ron Darling | | 119 | 103 | 16 |
| 1992-05-05 | @ OAK | 28 | W 5-1 | 19-9 | 1 | 18,753 | Juan Guzman | Joe Slusarski | Juan Guzman | Joe Slusarski | Duane Ward | 124 | 104 | 20 |
| 1992-05-06 | @ SEA | 29 | W 12-4 | 20-9 | 1 | 12,771 | Jimmy Key | Randy Johnson | Jimmy Key | Randy Johnson | | 136 | 108 | 28 |
| 1992-05-07 | @ SEA | 30 | W 8-7 | 21-9 | 1 | 13,347 | Jack Morris | Erik Hanson | Pat Hentgen | Mike Schooler | Tom Henke | 144 | 115 | 29 |
| 1992-05-08 | @ CAL | 31 | L 1-4 | 21-10 | 1 | 36,383 | Dave Stieb | Chuck Finley | Mark Eichhorn | Dave Stieb | | 145 | 119 | 26 |
| 1992-05-09 | @ CAL | 32 | L 1-2 | 21-11 | 2 | 36,159 | Todd Stottlemyre | Jim Abbott | Jim Abbott | Todd Stottlemyre | Bryan Harvey | 146 | 121 | 25 |
| 1992-05-10 | @ CAL | 33 | W 4-1 | 22-11 | 1 | 23,009 | Juan Guzman | Joe Grahe | Juan Guzman | Joe Grahe | | 150 | 122 | 28 |
| 1992-05-12 | vs OAK | 34 | W 3-0 | 23-11 | 1 | 50,407 | Jimmy Key | Dave Stewart | Jimmy Key | Dave Stewart | Tom Henke | 153 | 122 | 31 |
| 1992-05-13 | vs OAK | 35 | W 4-3 | 24-11 | 1 | 50,394 | Jack Morris | Mike Moore | Jack Morris | Mike Moore | Tom Henke | 157 | 125 | 32 |
| 1992-05-14 | vs SEA | 36 | W 5-4 | 25-11 | 1 | 50,375 | Dave Stieb | Russ Swan | Dave Stieb | Calvin Jones | David Wells | 162 | 129 | 33 |
| 1992-05-15 | vs SEA | 37 | L 1-2 | 25-12 | 2 | 50,405 | Todd Stottlemyre | Dave Fleming | Dave Fleming | Todd Stottlemyre | Mike Schooler | 163 | 131 | 32 |
| 1992-05-16 | vs SEA | 38 | L 6-7 | 25-13 | 2 | 50,385 | Juan Guzman | Clay Parker | Dennis Powell | David Wells | Mike Schooler | 169 | 138 | 31 |
| 1992-05-17 | vs SEA | 39 | L 2-3 | 25-14 | 2 | 50,364 | Jimmy Key | Randy Johnson | Randy Johnson | Jimmy Key | Mike Schooler | 171 | 141 | 30 |
| 1992-05-18 | vs MIN | 40 | L 2-6 | 25-15 | 2 | 50,391 | Jack Morris | Bill Krueger | Gary Wayne | Duane Ward | | 173 | 147 | 26 |
| 1992-05-19 | vs MIN | 41 | L 1-7 | 25-16 | 2 | 50,338 | Dave Stieb | Pat Mahomes | Pat Mahomes | Dave Stieb | Tom Edens | 174 | 154 | 20 |
| 1992-05-20 | vs MIN | 42 | W 8-7 | 26-16 | 1 | 50,125 | Todd Stottlemyre | Scott Erickson | Tom Henke | Rick Aguilera | | 182 | 161 | 21 |
| 1992-05-22 | @ CHA | 43 | W 6-2 | 27-16 | 1 | 37,446 | Juan Guzman | Jack McDowell | Juan Guzman | Jack McDowell | Duane Ward | 188 | 163 | 25 |
| 1992-05-23 | @ CHA | 44 | L 2-5 | 27-17 | 1 | 39,293 | Jimmy Key | Greg Hibbard | Greg Hibbard | Jimmy Key | Bobby Thigpen | 190 | 168 | 22 |
| 1992-05-24 | @ CHA | 45 | L 1-8 | 27-18 | 2 | 32,230 | Jack Morris | Kirk McCaskill | Kirk McCaskill | Jack Morris | | 191 | 176 | 15 |
| 1992-05-26 | vs MIL | 46 | W 5-4 | 28-18 | 2 | 49,360 | Dave Stieb | Ricky Bones | Dave Stieb | Ricky Bones | Tom Henke | 196 | 180 | 16 |
| 1992-05-27 | vs MIL | 47 | L 4-8 | 28-19 | 2 | 50,376 | Todd Stottlemyre | Jaime Navarro | Jaime Navarro | Todd Stottlemyre | Doug Henry | 200 | 188 | 12 |
| 1992-05-29 | vs CHA | 48 | W 3-0 | 29-19 | 1 | 50,408 | Juan Guzman | Greg Hibbard | Duane Ward | Greg Hibbard | Tom Henke | 203 | 188 | 15 |
| 1992-05-30 | vs CHA | 49 | W 2-1 | 30-19 | 1 | 50,391 | Jimmy Key | Kirk McCaskill | David Wells | Donn Pall | | 205 | 189 | 16 |
| 1992-05-31 | vs CHA | 50 | W 3-2 | 31-19 | 1 | 50,393 | Jack Morris | Charlie Hough | Jack Morris | Bobby Thigpen | | 208 | 191 | 17 |
| 1992-06-01 | @ MIN | 51 | W 5-3 | 32-19 | 1 | 20,134 | Dave Stieb | John Smiley | Duane Ward | Carl Willis | Tom Henke | 213 | 194 | 19 |
| 1992-06-02 | @ MIN | 52 | W 7-5 | 33-19 | 1 | 22,317 | Todd Stottlemyre | Pat Mahomes | Pat Hentgen | Gary Wayne | Tom Henke | 220 | 199 | 21 |
| 1992-06-03 | @ MIN | 53 | L 3-11 | 33-20 | 1 | 21,392 | Juan Guzman | Kevin Tapani | Kevin Tapani | Juan Guzman | | 223 | 210 | 13 |
| 1992-06-05 | @ BAL | 54 | L 0-1 | 33-21 | 2 | 45,803 | Jimmy Key | Rick Sutcliffe | Rick Sutcliffe | Jimmy Key | Gregg Olson | 223 | 211 | 12 |
| 1992-06-06 | @ BAL | 55 | W 4-3 | 34-21 | 1 | 45,520 | Jack Morris | Ben McDonald | Jack Morris | Ben McDonald | Tom Henke | 227 | 214 | 13 |
| 1992-06-07 | @ BAL | 56 | L 1-7 | 34-22 | 2 | 45,620 | Dave Stieb | Mike Mussina | Mike Mussina | Dave Stieb | | 228 | 221 | 7 |
| 1992-06-08 | @ NYA | 57 | W 16-3 | 35-22 | 2 | 18,166 | Todd Stottlemyre | Greg Cadaret | Todd Stottlemyre | Greg Cadaret | | 244 | 224 | 20 |
| 1992-06-09 | @ NYA | 58 | W 2-1 | 36-22 | 1 | 22,429 | Juan Guzman | Tim Leary | Juan Guzman | Tim Leary | Tom Henke | 246 | 225 | 21 |
| 1992-06-10 | @ NYA | 59 | W 10-3 | 37-22 | 1 | 25,229 | Jimmy Key | Scott Sanderson | Jimmy Key | Scott Sanderson | David Wells | 256 | 228 | 28 |
| 1992-06-11 | vs BOS | 60 | W 4-0 | 38-22 | 1 | 50,423 | Jack Morris | Roger Clemens | Jack Morris | Roger Clemens | | 260 | 228 | 32 |
| 1992-06-12 | vs BOS | 61 | L 0-5 | 38-23 | 2 | 50,387 | Dave Stieb | Frank Viola | Frank Viola | Dave Stieb | | 260 | 233 | 27 |
| 1992-06-13 | vs BOS | 62 | L 3-5 | 38-24 | 2 | 50,397 | Todd Stottlemyre | Joe Hesketh | Joe Hesketh | Todd Stottlemyre | Jeff Reardon | 263 | 238 | 25 |
| 1992-06-14 | vs BOS | 63 | W 6-2 | 39-24 | 1 | 50,412 | Juan Guzman | Mike Gardiner | Juan Guzman | Mike Gardiner | Duane Ward | 269 | 240 | 29 |
| 1992-06-16 | vs DET | 64 | L 3-4 | 39-25 | 1 | 50,394 | Jimmy Key | Bill Gullickson | Bill Gullickson | Jimmy Key | Mike Henneman | 272 | 244 | 28 |
| 1992-06-17 | vs DET | 65 | W 6-2 | 40-25 | 1 | 50,401 | Jack Morris | Kevin Ritz | Jack Morris | Kevin Ritz | Duane Ward | 278 | 246 | 32 |
| 1992-06-18 | vs DET | 66 | L 10-14 | 40-26 | 1 | 50,392 | Dave Stieb | Mark Leiter | Mike Munoz | Mike Timlin | Mike Henneman | 288 | 260 | 28 |
| 1992-06-19 | @ KCA | 67 | L 4-11 | 40-27 | 2 | 23,942 | Todd Stottlemyre | Mark Gubicza | Mark Gubicza | Todd Stottlemyre | | 292 | 271 | 21 |
| 1992-06-20 | @ KCA | 68 | W 6-1 | 41-27 | 1 | 29,194 | Juan Guzman | Mike Magnante | Juan Guzman | Mike Magnante | | 298 | 272 | 26 |
| 1992-06-21 | @ KCA | 69 | L 0-2 | 41-28 | 1 | 24,275 | Jimmy Key | Kevin Appier | Kevin Appier | Jimmy Key | Jeff Montgomery | 298 | 274 | 24 |
| 1992-06-22 | @ TEX | 70 | W 16-7 | 42-28 | 1 | 24,460 | Jack Morris | Jose Guzman | Jack Morris | Jose Guzman | | 314 | 281 | 33 |
| 1992-06-24 | @ TEX | 71 | W 3-2 | 43-28 | 1 | 23,798 | David Wells | Bobby Witt | David Wells | Bobby Witt | Tom Henke | 317 | 283 | 34 |
| 1992-06-26 | @ CLE | 72 | W 6-1 | 44-28 | 1 | 16,299 | Juan Guzman | Jack Armstrong | Juan Guzman | Jack Armstrong | | 323 | 284 | 39 |
| 1992-06-27 | @ CLE | 73 | L 4-6 | 44-29 | 1 | 40,560 | Jimmy Key | Charles Nagy | Eric Plunk | Duane Ward | | 327 | 290 | 37 |
| 1992-06-28 | @ CLE | 74 | L 6-7 | 44-30 | 1 | 23,560 | Jack Morris | Dennis Cook | Steve Olin | Duane Ward | Eric Plunk | 333 | 297 | 36 |
| 1992-06-29 | vs TEX | 75 | W 11-4 | 45-30 | 1 | 50,404 | Dave Stieb | Bobby Witt | Pat Hentgen | Bobby Witt | | 344 | 301 | 43 |
| 1992-06-30 | vs TEX | 76 | L 13-16 | 45-31 | 1 | 50,396 | David Wells | Kevin Brown | Kevin Brown | David Wells | | 357 | 317 | 40 |
| 1992-07-01 | vs TEX | 77 | W 3-2 | 46-31 | 1 | 50,379 | Juan Guzman | Todd Burns | Duane Ward | Jeff Russell | | 360 | 319 | 41 |
| 1992-07-03 | vs CAL | 78 | W 10-1 | 47-31 | 1 | 50,408 | Jimmy Key | Mark Langston | Jimmy Key | Mark Langston | | 370 | 320 | 50 |
| 1992-07-04 | vs CAL | 79 | W 8-6 | 48-31 | 1 | 50,418 | Jack Morris | Bert Blyleven | Jack Morris | Mark Eichhorn | Tom Henke | 378 | 326 | 52 |
| 1992-07-05 | vs CAL | 80 | W 6-2 | 49-31 | 1 | 50,398 | David Wells | Julio Valera | David Wells | Julio Valera | | 384 | 328 | 56 |
| 1992-07-06 | vs CAL | 81 | W 3-0 | 50-31 | 1 | 50,406 | Juan Guzman | Jim Abbott | Juan Guzman | Jim Abbott | Tom Henke | 387 | 328 | 59 |
| 1992-07-07 | vs SEA | 82 | W 4-3 | 51-31 | 1 | 50,397 | Pat Hentgen | Rich DeLucia | Duane Ward | Jeff Nelson | | 391 | 331 | 60 |
| 1992-07-08 | vs SEA | 83 | W 6-0 | 52-31 | 1 | 50,391 | Jimmy Key | Erik Hanson | Jimmy Key | Erik Hanson | | 397 | 331 | 66 |
| 1992-07-09 | vs OAK | 84 | W 4-3 | 53-31 | 1 | 50,402 | Jack Morris | Kelly Downs | Tom Henke | Rich Gossage | | 401 | 334 | 67 |
| 1992-07-10 | vs OAK | 85 | L 1-5 | 53-32 | 1 | 50,399 | David Wells | Bob Welch | Bob Welch | David Wells | | 402 | 339 | 63 |
| 1992-07-11 | vs OAK | 86 | L 1-3 | 53-33 | 1 | 50,414 | Juan Guzman | Mike Moore | Mike Moore | Juan Guzman | Dennis Eckersley | 403 | 342 | 61 |
| 1992-07-12 | vs OAK | 87 | L 0-8 | 53-34 | 1 | 50,392 | Pat Hentgen | Ron Darling | Ron Darling | Pat Hentgen | | 403 | 350 | 53 |
| 1992-07-16 | @ SEA | 88 | W 7-2 | 54-34 | 1 | 52,711 | Jack Morris | Randy Johnson | Jack Morris | Randy Johnson | | 410 | 352 | 58 |
| 1992-07-17 | @ SEA | 89 | L 6-8 | 54-35 | 1 | 24,160 | Jimmy Key | Erik Hanson | Erik Hanson | Jimmy Key | Russ Swan | 416 | 360 | 56 |
| 1992-07-18 | @ SEA | 90 | W 3-0 | 55-35 | 1 | 43,922 | Juan Guzman | Dave Fleming | Juan Guzman | Dave Fleming | Tom Henke | 419 | 360 | 59 |
| 1992-07-19 | @ SEA | 91 | W 8-4 | 56-35 | 1 | 28,560 | David Wells | Rich DeLucia | David Wells | Rich DeLucia | | 427 | 364 | 63 |
| 1992-07-20 | @ CAL | 92 | L 3-5 | 56-36 | 1 | 21,090 | Todd Stottlemyre | Tim Fortugno | Chuck Crim | Pat Hentgen | Joe Grahe | 430 | 369 | 61 |
| 1992-07-21 | @ CAL | 93 | W 9-5 | 57-36 | 1 | 21,581 | Jack Morris | Julio Valera | Jack Morris | Chuck Crim | Duane Ward | 439 | 374 | 65 |
| 1992-07-22 | @ CAL | 94 | L 4-5 | 57-37 | 1 | 22,178 | Jimmy Key | Chuck Finley | Joe Grahe | Jimmy Key | | 443 | 379 | 64 |
| 1992-07-23 | @ OAK | 95 | W 9-3 | 58-37 | 1 | 24,707 | Juan Guzman | Mike Moore | Dave Stieb | Mike Moore | | 452 | 382 | 70 |
| 1992-07-24 | @ OAK | 96 | L 5-6 | 58-38 | 1 | 30,206 | David Wells | Dave Stewart | Dennis Eckersley | Tom Henke | | 457 | 388 | 69 |
| 1992-07-25 | @ OAK | 97 | L 0-6 | 58-39 | 1 | 36,086 | Todd Stottlemyre | Ron Darling | Ron Darling | Todd Stottlemyre | | 457 | 394 | 63 |
| 1992-07-26 | @ OAK | 98 | L 1-9 | 58-40 | 1 | 34,595 | Jack Morris | Kelly Downs | Kelly Downs | Jack Morris | | 458 | 403 | 55 |
| 1992-07-28 | vs KCA | 99 | W 6-4 | 59-40 | 1 | 50,392 | Jimmy Key | Dennis Moeller | Jimmy Key | Dennis Moeller | Tom Henke | 464 | 407 | 57 |
| 1992-07-29 | vs KCA | 100 | L 2-5 | 59-41 | 1 | 50,418 | Dave Stieb | Kevin Appier | Kevin Appier | Mike Timlin | Jeff Montgomery | 466 | 412 | 54 |
| 1992-07-30 | vs KCA | 101 | W 3-0 | 60-41 | 1 | 50,417 | David Wells | Luis Aquino | David Wells | Luis Aquino | Tom Henke | 469 | 412 | 57 |
| 1992-07-31 | vs NYA | 102 | W 13-2 | 61-41 | 1 | 50,407 | Todd Stottlemyre | Shawn Hillegas | Todd Stottlemyre | Shawn Hillegas | | 482 | 414 | 68 |
| 1992-08-01 | vs NYA | 103 | W 3-1 | 62-41 | 1 | 50,420 | Jack Morris | Melido Perez | Jack Morris | Melido Perez | Tom Henke | 485 | 415 | 70 |
| 1992-08-02 | vs NYA | 104 | W 7-6 | 63-41 | 1 | 50,409 | Jimmy Key | Scott Sanderson | Mark Eichhorn | John Habyan | Duane Ward | 492 | 421 | 71 |
| 1992-08-03 | @ BOS | 105 | L 1-7 | 63-42 | 1 | 34,024 | Juan Guzman | Roger Clemens | Roger Clemens | Juan Guzman | | 493 | 428 | 65 |
| 1992-08-04 | @ BOS | 106 | L 4-9 | 63-43 | 1 | 33,294 | David Wells | Joe Hesketh | Joe Hesketh | David Wells | Greg Harris | 497 | 437 | 60 |
| 1992-08-05 | @ BOS | 107 | W 5-4 | 64-43 | 1 | 33,945 | Todd Stottlemyre | Danny Darwin | Mark Eichhorn | Daryl Irvine | Tom Henke | 502 | 441 | 61 |
| 1992-08-06 | @ DET | 108 | W 15-11 | 65-43 | 1 | 27,969 | Jack Morris | Frank Tanana | Jack Morris | Frank Tanana | | 517 | 452 | 65 |
| 1992-08-07 | @ DET | 109 | L 2-7 | 65-44 | 1 | 29,994 | Jimmy Key | Bill Gullickson | Bill Gullickson | Jimmy Key | | 519 | 459 | 60 |
| 1992-08-08 | @ DET | 110 | L 6-8 | 65-45 | 1 | 39,344 | Dave Stieb | Walt Terrell | John Kiely | Doug Linton | Mike Henneman | 525 | 467 | 58 |
| 1992-08-09 | @ DET | 111 | L 2-9 | 65-46 | 1 | 40,035 | David Wells | Dave Haas | Dave Haas | David Wells | | 527 | 476 | 51 |
| 1992-08-10 | vs BAL | 112 | W 8-4 | 66-46 | 1 | 50,395 | Todd Stottlemyre | Mike Mussina | Todd Stottlemyre | Mike Mussina | | 535 | 480 | 55 |
| 1992-08-11 | vs BAL | 113 | L 0-3 | 66-47 | 1 | 50,421 | Jack Morris | Alan Mills | Alan Mills | Jack Morris | Gregg Olson | 535 | 483 | 52 |
| 1992-08-12 | vs BAL | 114 | L 4-11 | 66-48 | 1 | 50,419 | Jimmy Key | Ben McDonald | Ben McDonald | Jimmy Key | | 539 | 494 | 45 |
| 1992-08-13 | vs BAL | 115 | W 4-2 | 67-48 | 1 | 50,405 | Doug Linton | Arthur Rhodes | Doug Linton | Arthur Rhodes | Tom Henke | 543 | 496 | 47 |
| 1992-08-14 | @ CLE | 116 | W 9-5 | 68-48 | 1 | 41,686 | David Wells | Rod Nichols | David Wells | Rod Nichols | | 552 | 501 | 51 |
| 1992-08-16 | @ CLE | 117 | L 2-4 | 69-49 | 1 | 0 | Todd Stottlemyre | Dennis Cook | Dennis Cook | Todd Stottlemyre | Steve Olin | 554 | 505 | 49 |
| 1992-08-16 | @ CLE | 118 | W 6-2 | 69-49 | 1 | 27,997 | Jack Morris | Dave Otto | Jack Morris | Dave Otto | | 560 | 507 | 53 |
| 1992-08-18 | @ MIL | 119 | W 12-1 | 70-49 | 1 | 31,297 | Jimmy Key | Bruce Ruffin | Jimmy Key | Bruce Ruffin | | 572 | 508 | 64 |
| 1992-08-19 | @ MIL | 120 | L 5-10 | 70-50 | 1 | 32,060 | Doug Linton | Chris Bosio | Chris Bosio | Doug Linton | | 577 | 518 | 59 |
| 1992-08-20 | @ MIL | 121 | L 3-16 | 70-51 | 1 | 34,702 | David Wells | Bill Wegman | Bill Wegman | David Wells | | 580 | 534 | 46 |
| 1992-08-21 | @ MIN | 122 | L 1-5 | 70-52 | 1 | 48,082 | Todd Stottlemyre | John Smiley | John Smiley | Todd Stottlemyre | | 581 | 539 | 42 |
| 1992-08-22 | @ MIN | 123 | W 4-2 | 71-52 | 1 | 50,465 | Jack Morris | David West | Jack Morris | David West | Tom Henke | 585 | 541 | 44 |
| 1992-08-23 | @ MIN | 124 | L 0-2 | 71-53 | 1 | 45,211 | Jimmy Key | Scott Erickson | Scott Erickson | Jimmy Key | | 585 | 543 | 42 |
| 1992-08-24 | @ CHA | 125 | L 4-8 | 71-54 | 1 | 32,837 | Doug Linton | Alex Fernandez | Alex Fernandez | Doug Linton | | 589 | 551 | 38 |
| 1992-08-25 | @ CHA | 126 | L 3-6 | 71-55 | 1 | 29,450 | David Wells | Charlie Hough | Charlie Hough | David Wells | Roberto Hernandez | 592 | 557 | 35 |
| 1992-08-26 | @ CHA | 127 | W 9-0 | 72-55 | 1 | 26,436 | Todd Stottlemyre | Kirk McCaskill | Todd Stottlemyre | Kirk McCaskill | | 601 | 557 | 44 |
| 1992-08-27 | vs MIL | 128 | W 5-4 | 73-55 | 1 | 50,415 | Jack Morris | Jaime Navarro | Jack Morris | Jaime Navarro | Tom Henke | 606 | 561 | 45 |
| 1992-08-28 | vs MIL | 129 | L 2-22 | 73-56 | 1 | 50,408 | Jimmy Key | Cal Eldred | Cal Eldred | Jimmy Key | | 608 | 583 | 25 |
| 1992-08-29 | vs MIL | 130 | L 2-7 | 73-57 | 1 | 50,413 | David Cone | Chris Bosio | Chris Bosio | David Cone | Darren Holmes | 610 | 590 | 20 |
| 1992-08-30 | vs MIL | 131 | W 5-3 | 74-57 | 1 | 50,412 | Juan Guzman | Bill Wegman | Duane Ward | Bill Wegman | Tom Henke | 615 | 593 | 22 |
| 1992-08-31 | vs CHA | 132 | W 9-2 | 75-57 | 1 | 50,417 | Todd Stottlemyre | Charlie Hough | Todd Stottlemyre | Charlie Hough | | 624 | 595 | 29 |
| 1992-09-01 | vs CHA | 133 | W 9-3 | 76-57 | 1 | 50,409 | Jack Morris | Kirk McCaskill | Jack Morris | Kirk McCaskill | | 633 | 598 | 35 |
| 1992-09-02 | vs CHA | 134 | L 2-3 | 76-58 | 1 | 50,419 | Jimmy Key | Greg Hibbard | Greg Hibbard | Jimmy Key | Roberto Hernandez | 635 | 601 | 34 |
| 1992-09-04 | vs MIN | 135 | W 16-5 | 77-58 | 1 | 50,420 | David Cone | Kevin Tapani | David Cone | Kevin Tapani | | 651 | 606 | 45 |
| 1992-09-05 | vs MIN | 136 | W 7-3 | 78-58 | 1 | 50,409 | Juan Guzman | John Smiley | Juan Guzman | John Smiley | | 658 | 609 | 49 |
| 1992-09-06 | vs MIN | 137 | W 4-2 | 79-58 | 1 | 50,421 | Todd Stottlemyre | Mike Trombley | Todd Stottlemyre | Mike Trombley | Tom Henke | 662 | 611 | 51 |
| 1992-09-07 | @ KCA | 138 | L 4-5 | 79-59 | 1 | 21,015 | Jack Morris | Rick Reed | Mike Magnante | David Wells | | 666 | 616 | 50 |
| 1992-09-08 | @ KCA | 139 | W 5-0 | 80-59 | 1 | 15,454 | Jimmy Key | Luis Aquino | Jimmy Key | Luis Aquino | | 671 | 616 | 55 |
| 1992-09-09 | @ KCA | 140 | W 1-0 | 81-59 | 1 | 17,730 | David Cone | Kevin Appier | David Cone | Kevin Appier | Tom Henke | 672 | 616 | 56 |
| 1992-09-11 | @ TEX | 141 | W 7-5 | 82-60 | 1 | 0 | Juan Guzman | Scott Chiamparino | Juan Guzman | Scott Chiamparino | Tom Henke | 679 | 621 | 58 |
| 1992-09-11 | @ TEX | 142 | L 3-4 | 82-60 | 1 | 19,396 | Todd Stottlemyre | Roger Pavlik | Roger Pavlik | Todd Stottlemyre | Todd Burns | 682 | 625 | 57 |
| 1992-09-12 | @ TEX | 143 | W 4-2 | 83-60 | 1 | 27,178 | Jack Morris | Dan Smith | Jack Morris | Dan Smith | Tom Henke | 686 | 627 | 59 |
| 1992-09-13 | @ TEX | 144 | W 7-2 | 84-60 | 1 | 16,654 | Jimmy Key | Kevin Brown | Jimmy Key | Kevin Brown | Duane Ward | 693 | 629 | 64 |
| 1992-09-14 | vs CLE | 145 | L 1-2 | 84-61 | 1 | 50,394 | David Cone | Jose Mesa | Jose Mesa | David Cone | Steve Olin | 694 | 631 | 63 |
| 1992-09-15 | vs CLE | 146 | W 5-4 | 85-61 | 1 | 49,487 | Juan Guzman | Alan Embree | Juan Guzman | Alan Embree | Tom Henke | 699 | 635 | 64 |
| 1992-09-16 | vs CLE | 147 | L 3-6 | 85-62 | 1 | 50,416 | Todd Stottlemyre | Charles Nagy | Charles Nagy | Todd Stottlemyre | Ted Power | 702 | 641 | 61 |
| 1992-09-17 | vs CLE | 148 | W 7-5 | 86-62 | 1 | 50,408 | Jack Morris | Scott Scudder | Duane Ward | Eric Plunk | | 709 | 646 | 63 |
| 1992-09-18 | vs TEX | 149 | W 13-0 | 87-62 | 1 | 50,416 | Jimmy Key | Kevin Brown | Jimmy Key | Kevin Brown | | 722 | 646 | 76 |
| 1992-09-19 | vs TEX | 150 | W 1-0 | 88-62 | 1 | 50,421 | David Cone | Scott Chiamparino | David Cone | Scott Chiamparino | Tom Henke | 723 | 646 | 77 |
| 1992-09-20 | vs TEX | 151 | L 5-7 | 88-63 | 1 | 50,405 | Juan Guzman | Jose Guzman | Jose Guzman | Juan Guzman | Matt Whiteside | 728 | 653 | 75 |
| 1992-09-22 | @ BAL | 152 | W 4-3 | 89-63 | 1 | 45,104 | Todd Stottlemyre | Rick Sutcliffe | Todd Stottlemyre | Rick Sutcliffe | Tom Henke | 732 | 656 | 76 |
| 1992-09-23 | @ BAL | 153 | L 1-4 | 89-64 | 1 | 45,660 | Jack Morris | Arthur Rhodes | Arthur Rhodes | Jack Morris | Gregg Olson | 733 | 660 | 73 |
| 1992-09-24 | @ BAL | 154 | W 8-2 | 90-64 | 1 | 45,739 | Jimmy Key | Ben McDonald | Jimmy Key | Ben McDonald | | 741 | 662 | 79 |
| 1992-09-25 | @ NYA | 155 | W 3-1 | 91-64 | 1 | 18,124 | David Cone | Melido Perez | David Cone | Melido Perez | Tom Henke | 744 | 663 | 81 |
| 1992-09-26 | @ NYA | 156 | L 1-2 | 91-65 | 1 | 23,438 | Juan Guzman | Bob Wickman | Bob Wickman | Juan Guzman | Steve Farr | 745 | 665 | 80 |
| 1992-09-27 | @ NYA | 157 | W 12-2 | 92-65 | 1 | 21,413 | Jack Morris | Scott Sanderson | Jack Morris | Scott Sanderson | | 757 | 667 | 90 |
| 1992-09-29 | vs BOS | 158 | W 5-2 | 93-65 | 1 | 50,418 | Jimmy Key | Danny Darwin | Jimmy Key | Danny Darwin | Tom Henke | 762 | 669 | 93 |
| 1992-09-30 | vs BOS | 159 | L 0-1 | 93-66 | 1 | 50,420 | David Cone | Frank Viola | Frank Viola | David Cone | | 762 | 670 | 92 |
| 1992-10-02 | vs DET | 160 | W 8-7 | 94-66 | 1 | 50,418 | Jack Morris | Bill Gullickson | Jack Morris | Bill Gullickson | Tom Henke | 770 | 677 | 93 |
| 1992-10-03 | vs DET | 161 | W 3-1 | 95-66 | 1 | 50,412 | Juan Guzman | Dave Haas | Juan Guzman | Dave Haas | Duane Ward | 773 | 678 | 95 |
| 1992-10-04 | vs DET | 162 | W 7-4 | 96-66 | 1 | 50,421 | Jimmy Key | Scott Aldred | Todd Stottlemyre | Scott Aldred | Mike Timlin | 780 | 682 | 98 |