| 1992-04-06 | @ SEA | 1 | W 12-10 | 1-0 | 3 | 55,918 | Nolan Ryan | Randy Johnson | Steve Fireovid | Mike Schooler | Jeff Russell | 12 | 10 | 2 |
| 1992-04-07 | @ SEA | 2 | W 4-0 | 2-0 | 4 | 15,009 | Kevin Brown | Erik Hanson | Kevin Brown | Erik Hanson | | 16 | 10 | 6 |
| 1992-04-08 | @ SEA | 3 | W 13-1 | 3-0 | 3 | 13,597 | Jose Guzman | Russ Swan | Jose Guzman | Russ Swan | | 29 | 11 | 18 |
| 1992-04-09 | @ SEA | 4 | W 9-1 | 4-0 | 3 | 12,436 | Jeff Robinson | Dave Fleming | Jeff Robinson | Dave Fleming | | 38 | 12 | 26 |
| 1992-04-10 | @ MIN | 5 | L 1-7 | 4-1 | 2 | 53,031 | Bobby Witt | Kevin Tapani | Kevin Tapani | Bobby Witt | | 39 | 19 | 20 |
| 1992-04-11 | @ MIN | 6 | W 10-8 | 5-1 | 2 | 50,818 | Brian Bohanon | Scott Erickson | Jeff Russell | Rick Aguilera | Kenny Rogers | 49 | 27 | 22 |
| 1992-04-12 | @ MIN | 7 | W 4-3 | 6-1 | 1 | 18,076 | Kevin Brown | Pat Mahomes | Kevin Brown | Bob Kipper | | 53 | 30 | 23 |
| 1992-04-13 | vs CAL | 8 | L 0-3 | 6-2 | 2 | 41,129 | Jose Guzman | Jim Abbott | Jim Abbott | Jose Guzman | Bryan Harvey | 53 | 33 | 20 |
| 1992-04-14 | vs CAL | 9 | L 1-8 | 6-3 | 3 | 22,707 | Jeff Robinson | Joe Grahe | Joe Grahe | Jeff Robinson | | 54 | 41 | 13 |
| 1992-04-15 | vs CAL | 10 | W 3-2 | 7-3 | 2 | 16,724 | Bobby Witt | Julio Valera | Bobby Witt | Julio Valera | Jeff Russell | 57 | 43 | 14 |
| 1992-04-16 | vs CAL | 11 | L 2-3 | 7-4 | 3 | 22,686 | Brian Bohanon | Don Robinson | Chuck Crim | Jeff Russell | Bryan Harvey | 59 | 46 | 13 |
| 1992-04-17 | vs OAK | 12 | W 6-5 | 8-4 | 2 | 33,070 | Kevin Brown | John Briscoe | Kevin Brown | John Briscoe | Kenny Rogers | 65 | 51 | 14 |
| 1992-04-18 | vs OAK | 13 | L 3-5 | 8-5 | 3 | 30,879 | Jose Guzman | Mike Moore | Mike Moore | Terry Mathews | Dennis Eckersley | 68 | 56 | 12 |
| 1992-04-19 | vs OAK | 14 | W 6-4 | 9-5 | 3 | 23,020 | Jeff Robinson | Ron Darling | Barry Manuel | Rick Honeycutt | Jeff Russell | 74 | 60 | 14 |
| 1992-04-21 | vs DET | 15 | L 2-4 | 9-6 | 3 | 20,220 | Bobby Witt | Bill Gullickson | Bill Gullickson | Bobby Witt | Mike Henneman | 76 | 64 | 12 |
| 1992-04-22 | vs DET | 16 | L 8-12 | 9-7 | 3 | 19,838 | Brian Bohanon | Scott Aldred | Mark Leiter | Jeff Robinson | | 84 | 76 | 8 |
| 1992-04-23 | vs DET | 17 | L 5-11 | 9-8 | 4 | 30,432 | Kevin Brown | Frank Tanana | Les Lancaster | Kevin Brown | John Doherty | 89 | 87 | 2 |
| 1992-04-24 | @ BOS | 18 | L 1-3 | 9-9 | 4 | 31,461 | Jose Guzman | Frank Viola | Frank Viola | Jose Guzman | | 90 | 90 | 0 |
| 1992-04-26 | @ BOS | 19 | W 3-1 | 11-9 | 3 | 0 | Bobby Witt | Matt Young | Bobby Witt | Matt Young | Jeff Russell | 93 | 91 | 2 |
| 1992-04-26 | @ BOS | 20 | W 4-2 | 11-9 | 3 | 32,728 | Jeff Robinson | Joe Hesketh | Terry Mathews | Greg Harris | Jeff Russell | 97 | 93 | 4 |
| 1992-04-27 | @ NYA | 21 | L 7-8 | 11-10 | 3 | 13,911 | Brian Bohanon | Scott Sanderson | John Habyan | Terry Mathews | Steve Farr | 104 | 101 | 3 |
| 1992-04-28 | @ NYA | 22 | W 1-0 | 12-10 | 3 | 14,520 | Kevin Brown | Tim Leary | Kevin Brown | Tim Leary | Jeff Russell | 105 | 101 | 4 |
| 1992-04-29 | @ NYA | 23 | W 5-1 | 13-10 | 2 | 14,270 | Jose Guzman | Greg Cadaret | Jose Guzman | Greg Cadaret | | 110 | 102 | 8 |
| 1992-04-30 | @ CHA | 24 | L 1-12 | 13-11 | 3 | 24,134 | Nolan Ryan | Jack McDowell | Jack McDowell | Nolan Ryan | | 111 | 114 | -3 |
| 1992-05-01 | @ CHA | 25 | W 8-4 | 14-11 | 2 | 32,213 | Bobby Witt | Greg Hibbard | Bobby Witt | Greg Hibbard | Jeff Russell | 119 | 118 | 1 |
| 1992-05-02 | @ CHA | 26 | W 4-1 | 15-11 | 2 | 29,172 | Roger Pavlik | Charlie Hough | Jeff Robinson | Bobby Thigpen | | 123 | 119 | 4 |
| 1992-05-03 | @ CHA | 27 | L 3-5 | 15-12 | 2 | 30,314 | Kevin Brown | Kirk McCaskill | Scott Radinsky | Kevin Brown | | 126 | 124 | 2 |
| 1992-05-04 | @ BAL | 28 | L 5-8 | 15-13 | 3 | 36,511 | Jose Guzman | Bob Milacki | Alan Mills | Terry Mathews | | 131 | 132 | -1 |
| 1992-05-05 | @ BAL | 29 | W 5-3 | 16-13 | 3 | 45,481 | Nolan Ryan | Jose Mesa | Jeff Robinson | Storm Davis | Jeff Russell | 136 | 135 | 1 |
| 1992-05-06 | vs CLE | 30 | L 2-7 | 16-14 | 3 | 17,125 | Bobby Witt | Scott Scudder | Scott Scudder | Bobby Witt | Kevin Wickander | 138 | 142 | -4 |
| 1992-05-07 | vs CLE | 31 | L 7-8 | 16-15 | 4 | 19,573 | Roger Pavlik | Dennis Cook | Rod Nichols | Mike Campbell | Steve Olin | 145 | 150 | -5 |
| 1992-05-08 | vs MIL | 32 | W 3-2 | 17-15 | 4 | 24,520 | Kevin Brown | Bill Wegman | Kevin Brown | Bill Wegman | Jeff Russell | 148 | 152 | -4 |
| 1992-05-09 | vs MIL | 33 | W 5-4 | 18-15 | 4 | 37,353 | Nolan Ryan | Ricky Bones | Jeff Robinson | Darren Holmes | Jeff Russell | 153 | 156 | -3 |
| 1992-05-10 | vs MIL | 34 | L 2-6 | 18-16 | 4 | 30,008 | Jose Guzman | Chris Bosio | Chris Bosio | Jose Guzman | | 155 | 162 | -7 |
| 1992-05-12 | vs BAL | 35 | L 1-5 | 18-17 | 4 | 20,575 | Bobby Witt | Ben McDonald | Ben McDonald | Bobby Witt | Todd Frohwirth | 156 | 167 | -11 |
| 1992-05-13 | vs BAL | 36 | L 2-4 | 18-18 | 5 | 20,743 | Kevin Brown | Rick Sutcliffe | Rick Sutcliffe | Kevin Brown | Gregg Olson | 158 | 171 | -13 |
| 1992-05-15 | @ MIL | 37 | L 3-7 | 18-19 | 5 | 14,790 | Jose Guzman | Chris Bosio | Darren Holmes | Jeff Robinson | | 161 | 178 | -17 |
| 1992-05-16 | @ MIL | 38 | L 4-5 | 18-20 | 5 | 30,256 | Nolan Ryan | Ricky Bones | Darren Holmes | Kenny Rogers | | 165 | 183 | -18 |
| 1992-05-17 | @ MIL | 39 | W 2-1 | 19-20 | 5 | 17,386 | Bobby Witt | Jaime Navarro | Jeff Russell | Jaime Navarro | | 167 | 184 | -17 |
| 1992-05-18 | @ CLE | 40 | W 3-2 | 20-20 | 5 | 4,438 | Kevin Brown | Scott Scudder | Kevin Brown | Derek Lilliquist | Kenny Rogers | 170 | 186 | -16 |
| 1992-05-19 | @ CLE | 41 | W 8-7 | 21-20 | 4 | 7,348 | Roger Pavlik | Jack Armstrong | Lance McCullers | Steve Olin | Jeff Russell | 178 | 193 | -15 |
| 1992-05-20 | @ CLE | 42 | W 1-0 | 22-20 | 4 | 6,687 | Jose Guzman | Charles Nagy | Jose Guzman | Charles Nagy | Jeff Russell | 179 | 193 | -14 |
| 1992-05-21 | vs KCA | 43 | L 5-7 | 22-21 | 4 | 21,363 | Nolan Ryan | Tom Gordon | Rusty Meacham | Kenny Rogers | Jeff Montgomery | 184 | 200 | -16 |
| 1992-05-22 | vs KCA | 44 | W 10-7 | 23-21 | 4 | 34,385 | Bobby Witt | Mark Gubicza | Bobby Witt | Mark Gubicza | | 194 | 207 | -13 |
| 1992-05-23 | vs KCA | 45 | W 4-2 | 24-21 | 4 | 33,347 | Kevin Brown | Mike Magnante | Kevin Brown | Mike Magnante | | 198 | 209 | -11 |
| 1992-05-24 | vs KCA | 46 | W 4-3 | 25-21 | 4 | 28,059 | Mike Jeffcoat | Kevin Appier | Gerald Alexander | Tom Gordon | | 202 | 212 | -10 |
| 1992-05-26 | vs CHA | 47 | W 6-5 | 26-21 | 3 | 20,019 | Jose Guzman | Charlie Hough | Jose Guzman | Charlie Hough | Ed Nunez | 208 | 217 | -9 |
| 1992-05-27 | vs CHA | 48 | W 4-3 | 27-21 | 2 | 25,958 | Nolan Ryan | Alex Fernandez | Floyd Bannister | Donn Pall | | 212 | 220 | -8 |
| 1992-05-28 | vs CHA | 49 | W 4-2 | 28-21 | 1 | 24,251 | Bobby Witt | Jack McDowell | Bobby Witt | Jack McDowell | Jeff Russell | 216 | 222 | -6 |
| 1992-05-29 | @ KCA | 50 | W 5-3 | 29-21 | 1 | 20,591 | Kevin Brown | Mike Magnante | Kevin Brown | Jeff Montgomery | | 221 | 225 | -4 |
| 1992-05-30 | @ KCA | 51 | L 2-8 | 29-22 | 1 | 25,657 | Mike Jeffcoat | Kevin Appier | Kevin Appier | Mike Jeffcoat | | 223 | 233 | -10 |
| 1992-05-31 | @ KCA | 52 | L 6-7 | 29-23 | 2 | 21,681 | Jose Guzman | Hipolito Pichardo | Rusty Meacham | Jeff Russell | | 229 | 240 | -11 |
| 1992-06-01 | vs NYA | 53 | L 1-7 | 29-24 | 3 | 23,284 | Nolan Ryan | Melido Perez | Rich Monteleone | Jeff Robinson | | 230 | 247 | -17 |
| 1992-06-02 | vs NYA | 54 | W 8-2 | 30-24 | 2 | 20,788 | Bobby Witt | Tim Leary | Bobby Witt | Tim Leary | | 238 | 249 | -11 |
| 1992-06-03 | vs NYA | 55 | W 4-3 | 31-24 | 2 | 28,879 | Kevin Brown | Greg Cadaret | Kenny Rogers | Shawn Hillegas | | 242 | 252 | -10 |
| 1992-06-04 | vs MIN | 56 | L 12-15 | 31-25 | 3 | 31,848 | Mike Jeffcoat | Bill Krueger | Bob Kipper | Ed Nunez | Rick Aguilera | 254 | 267 | -13 |
| 1992-06-05 | vs MIN | 57 | W 5-4 | 32-25 | 2 | 27,238 | Jose Guzman | Willie Banks | Jose Guzman | Willie Banks | Jeff Russell | 259 | 271 | -12 |
| 1992-06-06 | vs MIN | 58 | L 1-6 | 32-26 | 3 | 41,580 | Nolan Ryan | John Smiley | John Smiley | Nolan Ryan | | 260 | 277 | -17 |
| 1992-06-07 | vs MIN | 59 | W 5-4 | 33-26 | 2 | 33,836 | Bobby Witt | Scott Erickson | Bobby Witt | Mark Guthrie | Jeff Russell | 265 | 281 | -16 |
| 1992-06-08 | vs SEA | 60 | W 14-3 | 34-26 | 2 | 25,568 | Kevin Brown | Clay Parker | Kevin Brown | Clay Parker | | 279 | 284 | -5 |
| 1992-06-09 | vs SEA | 61 | L 1-2 | 34-27 | 2 | 42,273 | Todd Burns | Dave Fleming | Dave Fleming | Kenny Rogers | Mike Schooler | 280 | 286 | -6 |
| 1992-06-10 | vs SEA | 62 | W 5-3 | 35-27 | 2 | 35,378 | Jose Guzman | Randy Johnson | Jose Guzman | Randy Johnson | Jeff Russell | 285 | 289 | -4 |
| 1992-06-12 | @ OAK | 63 | L 5-6 | 35-28 | 2 | 43,200 | Nolan Ryan | Mike Moore | Jim Corsi | Floyd Bannister | | 290 | 295 | -5 |
| 1992-06-13 | @ OAK | 64 | L 1-7 | 35-29 | 2 | 36,768 | Bobby Witt | Dave Stewart | Dave Stewart | Bobby Witt | | 291 | 302 | -11 |
| 1992-06-14 | @ OAK | 65 | L 1-6 | 35-30 | 3 | 34,788 | Kevin Brown | Bob Welch | Bob Welch | Kevin Brown | | 292 | 308 | -16 |
| 1992-06-15 | @ CAL | 66 | W 5-2 | 36-30 | 2 | 19,127 | Todd Burns | Jim Abbott | Todd Burns | Jim Abbott | Jeff Russell | 297 | 310 | -13 |
| 1992-06-16 | @ CAL | 67 | L 1-4 | 36-31 | 2 | 51,401 | Jose Guzman | Bert Blyleven | Bert Blyleven | Jose Guzman | Joe Grahe | 298 | 314 | -16 |
| 1992-06-17 | @ CAL | 68 | L 0-3 | 36-32 | 3 | 37,135 | Nolan Ryan | Mark Langston | Mark Langston | Nolan Ryan | | 298 | 317 | -19 |
| 1992-06-19 | vs BOS | 69 | W 4-1 | 37-32 | 3 | 32,025 | Bobby Witt | Mike Gardiner | Bobby Witt | Mike Gardiner | Jeff Russell | 302 | 318 | -16 |
| 1992-06-20 | vs BOS | 70 | W 4-1 | 38-32 | 3 | 40,401 | Kevin Brown | John Dopson | Kevin Brown | John Dopson | Kenny Rogers | 306 | 319 | -13 |
| 1992-06-21 | vs BOS | 71 | W 3-2 | 39-32 | 3 | 32,648 | Todd Burns | Roger Clemens | Todd Burns | Roger Clemens | Jeff Russell | 309 | 321 | -12 |
| 1992-06-22 | vs TOR | 72 | L 7-16 | 39-33 | 3 | 24,460 | Jose Guzman | Jack Morris | Jack Morris | Jose Guzman | | 316 | 337 | -21 |
| 1992-06-24 | vs TOR | 73 | L 2-3 | 39-34 | 3 | 23,798 | Bobby Witt | David Wells | David Wells | Bobby Witt | Tom Henke | 318 | 340 | -22 |
| 1992-06-25 | @ DET | 74 | W 5-2 | 40-34 | 3 | 13,346 | Kevin Brown | Buddy Groom | Kevin Brown | Buddy Groom | | 323 | 342 | -19 |
| 1992-06-26 | @ DET | 75 | L 2-4 | 40-35 | 3 | 18,326 | Todd Burns | Bill Gullickson | Bill Gullickson | Todd Burns | Mike Henneman | 325 | 346 | -21 |
| 1992-06-27 | @ DET | 76 | W 10-8 | 41-35 | 3 | 36,180 | Jose Guzman | Kevin Ritz | Jose Guzman | Kevin Ritz | Kenny Rogers | 335 | 354 | -19 |
| 1992-06-28 | @ DET | 77 | W 8-4 | 42-35 | 3 | 42,394 | Nolan Ryan | Mark Leiter | Nolan Ryan | Mark Leiter | | 343 | 358 | -15 |
| 1992-06-29 | @ TOR | 78 | L 4-11 | 42-36 | 3 | 50,404 | Bobby Witt | Dave Stieb | Pat Hentgen | Bobby Witt | | 347 | 369 | -22 |
| 1992-06-30 | @ TOR | 79 | W 16-13 | 43-36 | 3 | 50,396 | Kevin Brown | David Wells | Kevin Brown | David Wells | | 363 | 382 | -19 |
| 1992-07-01 | @ TOR | 80 | L 2-3 | 43-37 | 3 | 50,379 | Todd Burns | Juan Guzman | Duane Ward | Jeff Russell | | 365 | 385 | -20 |
| 1992-07-03 | vs NYA | 81 | L 6-9 | 43-38 | 3 | 37,864 | Jose Guzman | Melido Perez | Melido Perez | Jose Guzman | John Habyan | 371 | 394 | -23 |
| 1992-07-04 | vs NYA | 82 | W 4-1 | 44-38 | 3 | 40,726 | Nolan Ryan | Scott Kamieniecki | Nolan Ryan | Scott Kamieniecki | | 375 | 395 | -20 |
| 1992-07-05 | vs NYA | 83 | L 4-5 | 44-39 | 3 | 28,558 | Bobby Witt | Scott Sanderson | Scott Sanderson | Danny Leon | John Habyan | 379 | 400 | -21 |
| 1992-07-06 | vs MIL | 84 | W 3-1 | 45-39 | 3 | 17,157 | Kevin Brown | Bill Wegman | Kevin Brown | Bill Wegman | Jeff Russell | 382 | 401 | -19 |
| 1992-07-07 | vs MIL | 85 | L 3-4 | 45-40 | 3 | 31,254 | Todd Burns | Bruce Ruffin | Jim Austin | Todd Burns | Doug Henry | 385 | 405 | -20 |
| 1992-07-08 | vs MIL | 86 | L 3-4 | 45-41 | 3 | 18,256 | Jose Guzman | Jaime Navarro | Mike Fetters | Jose Guzman | Doug Henry | 388 | 409 | -21 |
| 1992-07-09 | vs CLE | 87 | W 14-4 | 46-41 | 3 | 35,560 | Nolan Ryan | Scott Scudder | Nolan Ryan | Scott Scudder | | 402 | 413 | -11 |
| 1992-07-10 | vs CLE | 88 | W 6-5 | 47-41 | 3 | 25,916 | Brian Bohanon | Jack Armstrong | Brian Bohanon | Jack Armstrong | Jeff Russell | 408 | 418 | -10 |
| 1992-07-11 | vs CLE | 89 | W 5-1 | 48-41 | 3 | 33,046 | Kevin Brown | Jeff Mutis | Kevin Brown | Jeff Mutis | | 413 | 419 | -6 |
| 1992-07-12 | vs CLE | 90 | L 3-6 | 48-42 | 3 | 25,116 | Todd Burns | Dennis Cook | Steve Olin | Kenny Rogers | Eric Plunk | 416 | 425 | -9 |
| 1992-07-16 | vs BAL | 91 | W 5-2 | 49-42 | 3 | 36,545 | Nolan Ryan | Rick Sutcliffe | Nolan Ryan | Rick Sutcliffe | Jeff Russell | 421 | 427 | -6 |
| 1992-07-17 | vs BAL | 92 | L 0-8 | 49-43 | 3 | 30,882 | Kevin Brown | Mike Mussina | Mike Mussina | Kevin Brown | | 421 | 435 | -14 |
| 1992-07-18 | vs BAL | 93 | L 0-7 | 49-44 | 3 | 37,009 | Jose Guzman | Ben McDonald | Ben McDonald | Jose Guzman | | 421 | 442 | -21 |
| 1992-07-19 | vs BAL | 94 | L 2-3 | 49-45 | 3 | 33,155 | Todd Burns | Arthur Rhodes | Todd Frohwirth | Terry Mathews | Gregg Olson | 423 | 445 | -22 |
| 1992-07-20 | @ MIL | 95 | L 4-5 | 49-46 | 3 | 20,894 | Bobby Witt | Chris Bosio | Darren Holmes | Ed Nunez | | 427 | 450 | -23 |
| 1992-07-21 | @ MIL | 96 | W 6-3 | 50-46 | 3 | 26,148 | Nolan Ryan | Bill Wegman | Terry Mathews | Darren Holmes | Jeff Russell | 433 | 453 | -20 |
| 1992-07-22 | @ MIL | 97 | L 1-4 | 50-47 | 3 | 27,095 | Kevin Brown | Jaime Navarro | Jaime Navarro | Kevin Brown | | 434 | 457 | -23 |
| 1992-07-23 | @ BAL | 98 | W 4-2 | 51-47 | 3 | 45,572 | Jose Guzman | Ben McDonald | Jose Guzman | Ben McDonald | Jeff Russell | 438 | 459 | -21 |
| 1992-07-24 | @ BAL | 99 | L 2-9 | 51-48 | 3 | 45,758 | Todd Burns | Arthur Rhodes | Arthur Rhodes | Todd Burns | | 440 | 468 | -28 |
| 1992-07-25 | @ BAL | 100 | W 10-8 | 52-48 | 3 | 45,868 | Bobby Witt | Rick Sutcliffe | Bobby Witt | Rick Sutcliffe | Jeff Russell | 450 | 476 | -26 |
| 1992-07-26 | @ BAL | 101 | W 6-2 | 53-48 | 3 | 45,668 | Nolan Ryan | Mike Mussina | Nolan Ryan | Mike Mussina | Ed Nunez | 456 | 478 | -22 |
| 1992-07-27 | @ BOS | 102 | L 5-7 | 53-49 | 3 | 32,927 | Kevin Brown | Frank Viola | Frank Viola | Kevin Brown | Jeff Reardon | 461 | 485 | -24 |
| 1992-07-28 | @ BOS | 103 | W 2-1 | 54-49 | 3 | 33,188 | Jose Guzman | John Dopson | Danny Leon | Paul Quantrill | Jeff Russell | 463 | 486 | -23 |
| 1992-07-29 | @ BOS | 104 | L 5-6 | 54-50 | 3 | 31,587 | Todd Burns | Roger Clemens | Roger Clemens | Todd Burns | Jeff Reardon | 468 | 492 | -24 |
| 1992-07-31 | vs CAL | 105 | L 3-5 | 54-51 | 3 | 32,524 | Bobby Witt | Julio Valera | Chuck Crim | Bobby Witt | Joe Grahe | 471 | 497 | -26 |
| 1992-08-01 | vs CAL | 106 | L 1-6 | 54-52 | 3 | 36,933 | Nolan Ryan | Chuck Finley | Chuck Finley | Nolan Ryan | | 472 | 503 | -31 |
| 1992-08-02 | vs CAL | 107 | W 5-1 | 55-52 | 3 | 24,927 | Kevin Brown | Mark Langston | Kevin Brown | Mark Langston | | 477 | 504 | -27 |
| 1992-08-03 | vs OAK | 108 | L 1-4 | 55-53 | 3 | 32,533 | Jose Guzman | Mike Moore | Mike Moore | Jose Guzman | Dennis Eckersley | 478 | 508 | -30 |
| 1992-08-04 | vs OAK | 109 | L 0-9 | 55-54 | 4 | 27,572 | Brian Bohanon | Dave Stewart | Dave Stewart | Brian Bohanon | Kevin Campbell | 478 | 517 | -39 |
| 1992-08-05 | vs OAK | 110 | L 3-4 | 55-55 | 4 | 27,606 | Bobby Witt | Ron Darling | Ron Darling | Bobby Witt | Dennis Eckersley | 481 | 521 | -40 |
| 1992-08-06 | vs OAK | 111 | L 0-2 | 55-56 | 4 | 36,712 | Nolan Ryan | Kelly Downs | Kelly Downs | Nolan Ryan | Rick Honeycutt | 481 | 523 | -42 |
| 1992-08-07 | @ SEA | 112 | W 7-6 | 56-56 | 4 | 18,732 | Kevin Brown | Dave Fleming | Todd Burns | Russ Swan | Ed Nunez | 488 | 529 | -41 |
| 1992-08-08 | @ SEA | 113 | W 7-3 | 57-56 | 4 | 20,393 | Jose Guzman | Kerry Woodson | Jose Guzman | Kerry Woodson | | 495 | 532 | -37 |
| 1992-08-09 | @ SEA | 114 | L 5-6 | 57-57 | 4 | 16,037 | Brian Bohanon | Brian Fisher | Calvin Jones | Matt Whiteside | | 500 | 538 | -38 |
| 1992-08-10 | @ MIN | 115 | L 5-7 | 57-58 | 4 | 35,615 | Bobby Witt | Kevin Tapani | Kevin Tapani | Bobby Witt | Rick Aguilera | 505 | 545 | -40 |
| 1992-08-11 | @ MIN | 116 | L 2-3 | 57-59 | 4 | 45,957 | Nolan Ryan | John Smiley | John Smiley | Kenny Rogers | | 507 | 548 | -41 |
| 1992-08-12 | @ MIN | 117 | W 5-3 | 58-59 | 4 | 33,247 | Kevin Brown | Willie Banks | Kevin Brown | Rick Aguilera | Jeff Russell | 512 | 551 | -39 |
| 1992-08-13 | @ MIN | 118 | W 6-1 | 59-59 | 4 | 38,968 | Jose Guzman | Scott Erickson | Jose Guzman | Scott Erickson | | 518 | 552 | -34 |
| 1992-08-14 | vs DET | 119 | L 6-9 | 59-60 | 4 | 38,696 | Roger Pavlik | Dave Haas | Dave Haas | Roger Pavlik | Mike Henneman | 524 | 561 | -37 |
| 1992-08-15 | vs DET | 120 | L 3-10 | 59-61 | 4 | 31,008 | Bobby Witt | John Doherty | John Doherty | Bobby Witt | Mike Munoz | 527 | 571 | -44 |
| 1992-08-16 | vs DET | 121 | L 0-6 | 59-62 | 4 | 25,216 | Nolan Ryan | Frank Tanana | Frank Tanana | Nolan Ryan | | 527 | 577 | -50 |
| 1992-08-18 | @ CHA | 122 | L 0-3 | 59-63 | 4 | 29,564 | Kevin Brown | Jack McDowell | Jack McDowell | Kevin Brown | | 527 | 580 | -53 |
| 1992-08-19 | @ CHA | 123 | L 2-3 | 59-64 | 4 | 31,227 | Jose Guzman | Alex Fernandez | Alex Fernandez | Jose Guzman | Scott Radinsky | 529 | 583 | -54 |
| 1992-08-20 | @ CHA | 124 | W 6-1 | 60-64 | 4 | 31,959 | Roger Pavlik | Charlie Hough | Roger Pavlik | Charlie Hough | | 535 | 584 | -49 |
| 1992-08-21 | @ CLE | 125 | L 6-8 | 60-65 | 4 | 35,101 | Nolan Ryan | Dennis Cook | Dennis Cook | Nolan Ryan | Steve Olin | 541 | 592 | -51 |
| 1992-08-22 | @ CLE | 126 | L 1-6 | 60-66 | 4 | 16,799 | Bobby Witt | Jack Armstrong | Jack Armstrong | Bobby Witt | | 542 | 598 | -56 |
| 1992-08-23 | @ CLE | 127 | W 14-4 | 61-66 | 4 | 27,706 | Kevin Brown | Jose Mesa | Kenny Rogers | Steve Olin | | 556 | 602 | -46 |
| 1992-08-25 | vs KCA | 128 | W 6-2 | 62-66 | 4 | 26,586 | Jose Guzman | Kevin Appier | Jose Guzman | Kevin Appier | | 562 | 604 | -42 |
| 1992-08-26 | vs KCA | 129 | W 3-1 | 63-66 | 4 | 20,054 | Roger Pavlik | Luis Aquino | Roger Pavlik | Rich Sauveur | Jeff Russell | 565 | 605 | -40 |
| 1992-08-27 | vs KCA | 130 | L 2-7 | 63-67 | 4 | 18,993 | Nolan Ryan | Hipolito Pichardo | Hipolito Pichardo | Nolan Ryan | | 567 | 612 | -45 |
| 1992-08-28 | vs CHA | 131 | W 4-1 | 64-67 | 4 | 22,837 | Kevin Brown | Greg Hibbard | Kevin Brown | Greg Hibbard | | 571 | 613 | -42 |
| 1992-08-29 | vs CHA | 132 | L 4-6 | 64-68 | 4 | 34,863 | Bobby Witt | Jack McDowell | Jack McDowell | Bobby Witt | Roberto Hernandez | 575 | 619 | -44 |
| 1992-08-30 | vs CHA | 133 | W 10-4 | 65-68 | 4 | 16,275 | Jose Guzman | Alex Fernandez | Jose Guzman | Alex Fernandez | | 585 | 623 | -38 |
| 1992-08-31 | @ KCA | 134 | L 2-5 | 65-69 | 4 | 21,991 | Roger Pavlik | Chris Haney | Chris Haney | Roger Pavlik | Jeff Montgomery | 587 | 628 | -41 |
| 1992-09-01 | @ KCA | 135 | L 3-8 | 65-70 | 4 | 21,374 | Nolan Ryan | Hipolito Pichardo | Mike Boddicker | Todd Burns | | 590 | 636 | -46 |
| 1992-09-02 | @ KCA | 136 | W 6-2 | 66-70 | 4 | 15,784 | Kevin Brown | Rick Reed | Kevin Brown | Rick Reed | | 596 | 638 | -42 |
| 1992-09-04 | @ NYA | 137 | L 3-6 | 66-71 | 4 | 18,818 | Jose Guzman | Bob Wickman | Bob Wickman | Jose Guzman | Steve Farr | 599 | 644 | -45 |
| 1992-09-05 | @ NYA | 138 | W 7-3 | 67-71 | 4 | 20,956 | Roger Pavlik | Sam Militello | Roger Pavlik | Sam Militello | Kenny Rogers | 606 | 647 | -41 |
| 1992-09-06 | @ NYA | 139 | L 0-7 | 67-72 | 4 | 21,643 | Scott Chiamparino | Scott Kamieniecki | Scott Kamieniecki | Scott Chiamparino | | 606 | 654 | -48 |
| 1992-09-07 | vs BOS | 140 | L 0-3 | 67-73 | 4 | 29,699 | Nolan Ryan | Roger Clemens | Roger Clemens | Nolan Ryan | Joe Hesketh | 606 | 657 | -51 |
| 1992-09-08 | vs BOS | 141 | W 6-1 | 68-73 | 4 | 13,294 | Kevin Brown | Matt Young | Kevin Brown | Matt Young | | 612 | 658 | -46 |
| 1992-09-09 | vs BOS | 142 | W 3-2 | 69-73 | 4 | 13,542 | Jose Guzman | Danny Darwin | Jose Guzman | Danny Darwin | | 615 | 660 | -45 |
| 1992-09-11 | vs TOR | 143 | L 5-7 | 70-74 | 4 | 0 | Scott Chiamparino | Juan Guzman | Juan Guzman | Scott Chiamparino | Tom Henke | 620 | 667 | -47 |
| 1992-09-11 | vs TOR | 144 | W 4-3 | 70-74 | 4 | 19,396 | Roger Pavlik | Todd Stottlemyre | Roger Pavlik | Todd Stottlemyre | Todd Burns | 624 | 670 | -46 |
| 1992-09-12 | vs TOR | 145 | L 2-4 | 70-75 | 4 | 27,178 | Dan Smith | Jack Morris | Jack Morris | Dan Smith | Tom Henke | 626 | 674 | -48 |
| 1992-09-13 | vs TOR | 146 | L 2-7 | 70-76 | 4 | 16,654 | Kevin Brown | Jimmy Key | Jimmy Key | Kevin Brown | Duane Ward | 628 | 681 | -53 |
| 1992-09-15 | @ DET | 147 | W 6-5 | 71-76 | 4 | 10,756 | Jose Guzman | Bill Gullickson | Jose Guzman | Bill Gullickson | Matt Whiteside | 634 | 686 | -52 |
| 1992-09-16 | @ DET | 148 | L 1-4 | 71-77 | 4 | 11,188 | Roger Pavlik | Dave Haas | Dave Haas | Roger Pavlik | Mike Henneman | 635 | 690 | -55 |
| 1992-09-18 | @ TOR | 149 | L 0-13 | 71-78 | 4 | 50,416 | Kevin Brown | Jimmy Key | Jimmy Key | Kevin Brown | | 635 | 703 | -68 |
| 1992-09-19 | @ TOR | 150 | L 0-1 | 71-79 | 4 | 50,421 | Scott Chiamparino | David Cone | David Cone | Scott Chiamparino | Tom Henke | 635 | 704 | -69 |
| 1992-09-20 | @ TOR | 151 | W 7-5 | 72-79 | 4 | 50,405 | Jose Guzman | Juan Guzman | Jose Guzman | Juan Guzman | Matt Whiteside | 642 | 709 | -67 |
| 1992-09-22 | vs MIN | 152 | L 0-1 | 72-80 | 4 | 18,721 | Nolan Ryan | John Smiley | Larry Casian | Kenny Rogers | Rick Aguilera | 642 | 710 | -68 |
| 1992-09-23 | vs MIN | 153 | W 5-3 | 73-80 | 4 | 14,898 | Kevin Brown | Mike Trombley | Kevin Brown | Mike Trombley | | 647 | 713 | -66 |
| 1992-09-25 | vs SEA | 154 | L 3-4 | 73-81 | 4 | 19,822 | Jose Guzman | Erik Hanson | Dennis Powell | Dan Smith | Brian Fisher | 650 | 717 | -67 |
| 1992-09-26 | vs SEA | 155 | L 4-8 | 73-82 | 4 | 31,122 | Roger Pavlik | Dave Fleming | Dave Fleming | Roger Pavlik | | 654 | 725 | -71 |
| 1992-09-27 | vs SEA | 156 | W 3-2 | 74-82 | 4 | 27,538 | Nolan Ryan | Randy Johnson | Matt Whiteside | Jeff Nelson | | 657 | 727 | -70 |
| 1992-09-29 | @ OAK | 157 | L 0-5 | 74-83 | 4 | 37,069 | Kevin Brown | Mike Moore | Mike Moore | Kevin Brown | | 657 | 732 | -75 |
| 1992-09-30 | @ OAK | 158 | W 7-3 | 75-83 | 4 | 25,601 | Jose Guzman | Bob Welch | Jose Guzman | Bob Welch | Matt Whiteside | 664 | 735 | -71 |
| 1992-10-01 | @ OAK | 159 | W 4-3 | 76-83 | 4 | 29,210 | Roger Pavlik | Dave Stewart | Kenny Rogers | Vince Horsman | Matt Whiteside | 668 | 738 | -70 |
| 1992-10-02 | @ CAL | 160 | L 3-6 | 76-84 | 4 | 18,526 | Scott Chiamparino | Mark Langston | Mark Langston | Scott Chiamparino | | 671 | 744 | -73 |
| 1992-10-03 | @ CAL | 161 | L 2-4 | 76-85 | 4 | 29,770 | Dan Smith | Hilly Hathaway | Scott Lewis | Dan Smith | Joe Grahe | 673 | 748 | -75 |
| 1992-10-04 | @ CAL | 162 | W 9-5 | 77-85 | 4 | 21,986 | Kevin Brown | Bert Blyleven | Kevin Brown | Bert Blyleven | | 682 | 753 | -71 |