| 1992-04-06 | vs KCA | 1 | W 5-3 | 1-0 | 2 | 44,078 | Dave Stewart | Kevin Appier | Rick Honeycutt | Luis Aquino | Dennis Eckersley | 5 | 3 | 2 |
| 1992-04-08 | vs KCA | 2 | W 4-3 | 2-0 | 2 | 42,421 | Mike Moore | Tom Gordon | Jeff Parrett | Neal Heaton | | 9 | 6 | 3 |
| 1992-04-09 | vs KCA | 3 | W 5-2 | 3-0 | 2 | 20,211 | Ron Darling | Mark Gubicza | Ron Darling | Mark Gubicza | Dennis Eckersley | 14 | 8 | 6 |
| 1992-04-10 | vs CHA | 4 | W 6-5 | 4-0 | 1 | 38,457 | Joe Slusarski | Alex Fernandez | Joe Slusarski | Alex Fernandez | Dennis Eckersley | 20 | 13 | 7 |
| 1992-04-11 | vs CHA | 5 | W 7-6 | 5-0 | 1 | 36,007 | Dave Stewart | Charlie Hough | Jeff Parrett | Terry Leach | | 27 | 19 | 8 |
| 1992-04-12 | vs CHA | 6 | L 4-6 | 5-1 | 2 | 27,462 | John Briscoe | Jack McDowell | Jack McDowell | Gene Nelson | Bobby Thigpen | 31 | 25 | 6 |
| 1992-04-13 | @ KCA | 7 | W 6-1 | 6-1 | 1 | 39,428 | Mike Moore | Tom Gordon | Mike Moore | Tom Gordon | | 37 | 26 | 11 |
| 1992-04-14 | @ KCA | 8 | L 1-3 | 6-2 | 1 | 17,321 | Ron Darling | Mark Gubicza | Neal Heaton | Rick Honeycutt | Jeff Montgomery | 38 | 29 | 9 |
| 1992-04-15 | @ KCA | 9 | W 10-6 | 7-2 | 1 | 16,519 | Joe Slusarski | Mark Davis | Jeff Parrett | Mike Magnante | Vince Horsman | 48 | 35 | 13 |
| 1992-04-16 | @ KCA | 10 | W 1-0 | 8-2 | 1 | 22,041 | Dave Stewart | Kevin Appier | Dave Stewart | Jeff Montgomery | Dennis Eckersley | 49 | 35 | 14 |
| 1992-04-17 | @ TEX | 11 | L 5-6 | 8-3 | 1 | 33,070 | John Briscoe | Kevin Brown | Kevin Brown | John Briscoe | Kenny Rogers | 54 | 41 | 13 |
| 1992-04-18 | @ TEX | 12 | W 5-3 | 9-3 | 1 | 30,879 | Mike Moore | Jose Guzman | Mike Moore | Terry Mathews | Dennis Eckersley | 59 | 44 | 15 |
| 1992-04-19 | @ TEX | 13 | L 4-6 | 9-4 | 1 | 23,020 | Ron Darling | Jeff Robinson | Barry Manuel | Rick Honeycutt | Jeff Russell | 63 | 50 | 13 |
| 1992-04-20 | vs CAL | 14 | W 4-3 | 10-4 | 1 | 24,106 | Joe Slusarski | Joe Grahe | Dennis Eckersley | Chuck Crim | | 67 | 53 | 14 |
| 1992-04-21 | vs CAL | 15 | L 2-3 | 10-5 | 1 | 22,369 | Dave Stewart | Don Robinson | Julio Valera | Dave Stewart | Bryan Harvey | 69 | 56 | 13 |
| 1992-04-22 | vs CAL | 16 | W 10-4 | 11-5 | 1 | 31,282 | Mike Moore | Chuck Finley | Mike Moore | Chuck Finley | | 79 | 60 | 19 |
| 1992-04-24 | @ MIN | 17 | L 5-6 | 11-6 | 1 | 26,706 | Ron Darling | John Smiley | Tom Edens | Rich Gossage | | 84 | 66 | 18 |
| 1992-04-25 | @ MIN | 18 | W 8-4 | 12-6 | 1 | 34,925 | Joe Slusarski | Kevin Tapani | Joe Slusarski | Kevin Tapani | Dennis Eckersley | 92 | 70 | 22 |
| 1992-04-26 | @ MIN | 19 | L 4-8 | 12-7 | 1 | 26,893 | Dave Stewart | Pat Mahomes | Pat Mahomes | Dave Stewart | Rick Aguilera | 96 | 78 | 18 |
| 1992-04-28 | @ CLE | 20 | W 3-1 | 13-7 | 1 | 5,028 | Mike Moore | Charles Nagy | Mike Moore | Steve Olin | Dennis Eckersley | 99 | 79 | 20 |
| 1992-04-29 | @ CLE | 21 | L 2-5 | 13-8 | 1 | 5,055 | Ron Darling | Dave Otto | Dave Otto | Ron Darling | Steve Olin | 101 | 84 | 17 |
| 1992-04-30 | @ DET | 22 | W 10-6 | 14-8 | 1 | 9,906 | Joe Slusarski | Scott Aldred | Vince Horsman | Mark Leiter | Dennis Eckersley | 111 | 90 | 21 |
| 1992-05-01 | @ DET | 23 | W 7-6 | 15-8 | 1 | 13,277 | Dave Stewart | Walt Terrell | Jeff Parrett | Mike Henneman | Dennis Eckersley | 118 | 96 | 22 |
| 1992-05-02 | @ DET | 24 | L 3-5 | 15-9 | 1 | 15,492 | Bob Welch | Frank Tanana | Frank Tanana | Bob Welch | Mike Henneman | 121 | 101 | 20 |
| 1992-05-03 | @ DET | 25 | L 4-8 | 15-10 | 1 | 18,353 | Mike Moore | Eric King | Eric King | Mike Moore | Mike Henneman | 125 | 109 | 16 |
| 1992-05-04 | vs TOR | 26 | L 3-7 | 15-11 | 1 | 20,137 | Ron Darling | Todd Stottlemyre | Todd Stottlemyre | Ron Darling | | 128 | 116 | 12 |
| 1992-05-05 | vs TOR | 27 | L 1-5 | 15-12 | 2 | 18,753 | Joe Slusarski | Juan Guzman | Juan Guzman | Joe Slusarski | Duane Ward | 129 | 121 | 8 |
| 1992-05-06 | vs DET | 28 | W 5-2 | 16-12 | 2 | 18,689 | Dave Stewart | Walt Terrell | Dave Stewart | Walt Terrell | Dennis Eckersley | 134 | 123 | 11 |
| 1992-05-07 | vs DET | 29 | W 6-2 | 17-12 | 2 | 23,155 | Bob Welch | Frank Tanana | Bob Welch | Frank Tanana | Dennis Eckersley | 140 | 125 | 15 |
| 1992-05-08 | vs NYA | 30 | W 8-6 | 18-12 | 2 | 34,320 | Mike Moore | Scott Kamieniecki | Gene Nelson | John Habyan | Dennis Eckersley | 148 | 131 | 17 |
| 1992-05-09 | vs NYA | 31 | W 5-3 | 19-12 | 1 | 41,315 | Ron Darling | Tim Leary | Ron Darling | Tim Leary | Rick Honeycutt | 153 | 134 | 19 |
| 1992-05-10 | vs NYA | 32 | W 5-2 | 20-12 | 1 | 37,154 | Joe Slusarski | Greg Cadaret | Joe Slusarski | Greg Cadaret | Dennis Eckersley | 158 | 136 | 22 |
| 1992-05-12 | @ TOR | 33 | L 0-3 | 20-13 | 1 | 50,407 | Dave Stewart | Jimmy Key | Jimmy Key | Dave Stewart | Tom Henke | 158 | 139 | 19 |
| 1992-05-13 | @ TOR | 34 | L 3-4 | 20-14 | 2 | 50,394 | Mike Moore | Jack Morris | Jack Morris | Mike Moore | Tom Henke | 161 | 143 | 18 |
| 1992-05-15 | @ NYA | 35 | L 2-3 | 20-15 | 2 | 20,563 | Bob Welch | Scott Kamieniecki | Scott Kamieniecki | Bob Welch | Steve Farr | 163 | 146 | 17 |
| 1992-05-16 | @ NYA | 36 | W 6-3 | 21-15 | 1 | 30,934 | Ron Darling | Tim Leary | Ron Darling | Tim Leary | Dennis Eckersley | 169 | 149 | 20 |
| 1992-05-17 | @ NYA | 37 | L 2-11 | 21-16 | 2 | 29,850 | Dave Stewart | Melido Perez | Melido Perez | Dave Stewart | | 171 | 160 | 11 |
| 1992-05-18 | @ BAL | 38 | W 8-4 | 22-16 | 1 | 43,907 | Mike Moore | Rick Sutcliffe | Mike Moore | Rick Sutcliffe | | 179 | 164 | 15 |
| 1992-05-19 | @ BAL | 39 | W 5-3 | 23-16 | 1 | 45,799 | Joe Slusarski | Jose Mesa | Joe Slusarski | Jose Mesa | Dennis Eckersley | 184 | 167 | 17 |
| 1992-05-20 | @ BAL | 40 | W 4-2 | 24-16 | 1 | 45,947 | Bob Welch | Mike Mussina | Bob Welch | Mike Mussina | Dennis Eckersley | 188 | 169 | 19 |
| 1992-05-22 | @ BOS | 41 | W 5-3 | 25-16 | 1 | 33,591 | Dave Stewart | Frank Viola | Dave Stewart | Frank Viola | Dennis Eckersley | 193 | 172 | 21 |
| 1992-05-23 | @ BOS | 42 | L 1-5 | 25-17 | 1 | 33,186 | Mike Moore | John Dopson | John Dopson | Mike Moore | | 194 | 177 | 17 |
| 1992-05-24 | @ BOS | 43 | W 4-0 | 26-17 | 1 | 33,965 | Ron Darling | Mike Gardiner | Ron Darling | Mike Gardiner | | 198 | 177 | 21 |
| 1992-05-25 | vs CLE | 44 | L 6-10 | 26-18 | 1 | 41,050 | Joe Slusarski | Charles Nagy | Charles Nagy | Joe Slusarski | Ted Power | 204 | 187 | 17 |
| 1992-05-26 | vs CLE | 45 | L 0-1 | 26-19 | 1 | 18,842 | Bob Welch | Dave Otto | Dave Otto | Bob Welch | Steve Olin | 204 | 188 | 16 |
| 1992-05-27 | vs CLE | 46 | L 2-4 | 26-20 | 1 | 24,679 | Dave Stewart | Scott Scudder | Scott Scudder | Dave Stewart | Steve Olin | 206 | 192 | 14 |
| 1992-05-29 | vs BAL | 47 | W 5-3 | 27-20 | 2 | 31,389 | Mike Moore | Bob Milacki | Mike Moore | Bob Milacki | Dennis Eckersley | 211 | 195 | 16 |
| 1992-05-30 | vs BAL | 48 | L 6-7 | 27-21 | 3 | 35,152 | Joe Slusarski | Jose Mesa | Jose Mesa | Joe Slusarski | Gregg Olson | 217 | 202 | 15 |
| 1992-05-31 | vs BAL | 49 | L 2-4 | 27-22 | 3 | 42,253 | Ron Darling | Rick Sutcliffe | Rick Sutcliffe | Ron Darling | Gregg Olson | 219 | 206 | 13 |
| 1992-06-01 | vs BOS | 50 | W 10-7 | 28-22 | 2 | 24,518 | Dave Stewart | Frank Viola | Kevin Campbell | Danny Darwin | | 229 | 213 | 16 |
| 1992-06-02 | vs BOS | 51 | W 5-4 | 29-22 | 1 | 25,553 | Mike Moore | Joe Hesketh | Mike Moore | Joe Hesketh | Dennis Eckersley | 234 | 217 | 17 |
| 1992-06-03 | vs BOS | 52 | W 7-6 | 30-22 | 1 | 31,294 | Joe Slusarski | John Dopson | Jeff Parrett | Mike Gardiner | Dennis Eckersley | 241 | 223 | 18 |
| 1992-06-05 | @ CHA | 53 | W 10-3 | 31-22 | 1 | 37,117 | Ron Darling | Kirk McCaskill | Ron Darling | Kirk McCaskill | | 251 | 226 | 25 |
| 1992-06-06 | @ CHA | 54 | W 6-4 | 32-22 | 1 | 42,483 | Dave Stewart | Alex Fernandez | Dave Stewart | Alex Fernandez | Dennis Eckersley | 257 | 230 | 27 |
| 1992-06-07 | @ CHA | 55 | L 1-6 | 32-23 | 1 | 42,415 | Mike Moore | Charlie Hough | Charlie Hough | Mike Moore | | 258 | 236 | 22 |
| 1992-06-08 | @ MIL | 56 | L 2-6 | 32-24 | 1 | 13,238 | Joe Slusarski | Bill Wegman | Bill Wegman | Joe Slusarski | | 260 | 242 | 18 |
| 1992-06-09 | @ MIL | 57 | W 6-1 | 33-24 | 1 | 15,056 | Kevin Campbell | Ron Robinson | Kevin Campbell | Ron Robinson | | 266 | 243 | 23 |
| 1992-06-10 | @ MIL | 58 | W 5-2 | 34-24 | 1 | 21,432 | Ron Darling | Chris Bosio | Ron Darling | Chris Bosio | Dennis Eckersley | 271 | 245 | 26 |
| 1992-06-12 | vs TEX | 59 | W 6-5 | 35-24 | 1 | 43,200 | Mike Moore | Nolan Ryan | Jim Corsi | Floyd Bannister | | 277 | 250 | 27 |
| 1992-06-13 | vs TEX | 60 | W 7-1 | 36-24 | 1 | 36,768 | Dave Stewart | Bobby Witt | Dave Stewart | Bobby Witt | | 284 | 251 | 33 |
| 1992-06-14 | vs TEX | 61 | W 6-1 | 37-24 | 1 | 34,788 | Bob Welch | Kevin Brown | Bob Welch | Kevin Brown | | 290 | 252 | 38 |
| 1992-06-15 | vs MIL | 62 | W 3-2 | 38-24 | 1 | 22,140 | Kevin Campbell | Chris Bosio | Dennis Eckersley | Mike Fetters | | 293 | 254 | 39 |
| 1992-06-16 | vs MIL | 63 | L 0-10 | 38-25 | 1 | 29,679 | Ron Darling | Ron Robinson | Ron Robinson | Ron Darling | | 293 | 264 | 29 |
| 1992-06-17 | vs MIL | 64 | L 2-10 | 38-26 | 1 | 27,881 | Mike Moore | Jaime Navarro | Jaime Navarro | Mike Moore | | 295 | 274 | 21 |
| 1992-06-19 | @ CAL | 65 | W 12-8 | 39-26 | 1 | 30,513 | Dave Stewart | Chuck Finley | Dave Stewart | Chuck Finley | Dennis Eckersley | 307 | 282 | 25 |
| 1992-06-20 | @ CAL | 66 | L 0-10 | 39-27 | 1 | 26,344 | Bob Welch | Julio Valera | Julio Valera | Bob Welch | | 307 | 292 | 15 |
| 1992-06-21 | @ CAL | 67 | L 2-4 | 39-28 | 1 | 38,505 | Mike Moore | Jim Abbott | Jim Abbott | Mike Moore | Joe Grahe | 309 | 296 | 13 |
| 1992-06-22 | vs SEA | 68 | W 7-2 | 40-28 | 1 | 23,067 | Ron Darling | Erik Hanson | Ron Darling | Erik Hanson | Dennis Eckersley | 316 | 298 | 18 |
| 1992-06-23 | vs SEA | 69 | W 12-7 | 41-28 | 1 | 27,963 | Joe Slusarski | Randy Kramer | Joe Slusarski | Randy Kramer | | 328 | 305 | 23 |
| 1992-06-24 | vs SEA | 70 | W 7-2 | 42-28 | 1 | 26,353 | Dave Stewart | Dave Fleming | Dave Stewart | Dave Fleming | | 335 | 307 | 28 |
| 1992-06-25 | vs MIN | 71 | W 5-1 | 43-28 | 1 | 30,238 | Bob Welch | Bill Krueger | Bob Welch | Bill Krueger | Dennis Eckersley | 340 | 308 | 32 |
| 1992-06-26 | vs MIN | 72 | L 3-4 | 43-29 | 1 | 35,577 | Mike Moore | Willie Banks | Willie Banks | Mike Moore | Rick Aguilera | 343 | 312 | 31 |
| 1992-06-27 | vs MIN | 73 | L 2-12 | 43-30 | 1 | 42,658 | Ron Darling | John Smiley | John Smiley | Ron Darling | | 345 | 324 | 21 |
| 1992-06-28 | vs MIN | 74 | L 2-10 | 43-31 | 2 | 38,976 | Kevin Campbell | Scott Erickson | Scott Erickson | Kevin Campbell | | 347 | 334 | 13 |
| 1992-06-29 | @ SEA | 75 | W 5-4 | 44-31 | 2 | 21,463 | Dave Stewart | Dave Fleming | Vince Horsman | Mike Schooler | Dennis Eckersley | 352 | 338 | 14 |
| 1992-06-30 | @ SEA | 76 | W 4-2 | 45-31 | 2 | 18,843 | Bob Welch | Rich DeLucia | Bob Welch | Jeff Nelson | Dennis Eckersley | 356 | 340 | 16 |
| 1992-07-01 | @ SEA | 77 | W 3-1 | 46-31 | 2 | 21,127 | Mike Moore | Mark Grant | Mike Moore | Mark Grant | Dennis Eckersley | 359 | 341 | 18 |
| 1992-07-03 | @ CLE | 78 | L 1-8 | 46-32 | 2 | 44,849 | Ron Darling | Charles Nagy | Charles Nagy | Ron Darling | | 360 | 349 | 11 |
| 1992-07-04 | @ CLE | 79 | L 1-8 | 46-33 | 2 | 18,510 | Kelly Downs | Scott Scudder | Scott Scudder | Kelly Downs | Ted Power | 361 | 357 | 4 |
| 1992-07-05 | @ CLE | 80 | W 5-2 | 47-33 | 2 | 30,598 | Bob Welch | Jack Armstrong | Bob Welch | Jack Armstrong | Dennis Eckersley | 366 | 359 | 7 |
| 1992-07-06 | @ CLE | 81 | W 13-4 | 48-33 | 2 | 12,057 | Mike Moore | Jeff Mutis | Mike Moore | Jeff Mutis | | 379 | 363 | 16 |
| 1992-07-07 | @ DET | 82 | L 2-3 | 48-34 | 2 | 17,548 | Ron Darling | Kevin Ritz | Kevin Ritz | Ron Darling | Mike Henneman | 381 | 366 | 15 |
| 1992-07-08 | @ DET | 83 | L 3-6 | 48-35 | 2 | 16,722 | Gene Nelson | Mark Leiter | Les Lancaster | Jim Corsi | Mike Henneman | 384 | 372 | 12 |
| 1992-07-09 | @ TOR | 84 | L 3-4 | 48-36 | 2 | 50,402 | Kelly Downs | Jack Morris | Tom Henke | Rich Gossage | | 387 | 376 | 11 |
| 1992-07-10 | @ TOR | 85 | W 5-1 | 49-36 | 2 | 50,399 | Bob Welch | David Wells | Bob Welch | David Wells | | 392 | 377 | 15 |
| 1992-07-11 | @ TOR | 86 | W 3-1 | 50-36 | 2 | 50,414 | Mike Moore | Juan Guzman | Mike Moore | Juan Guzman | Dennis Eckersley | 395 | 378 | 17 |
| 1992-07-12 | @ TOR | 87 | W 8-0 | 51-36 | 2 | 50,392 | Ron Darling | Pat Hentgen | Ron Darling | Pat Hentgen | | 403 | 378 | 25 |
| 1992-07-16 | vs DET | 88 | W 4-0 | 52-36 | 2 | 30,236 | Kelly Downs | Frank Tanana | Kelly Downs | Frank Tanana | | 407 | 378 | 29 |
| 1992-07-17 | vs DET | 89 | L 3-4 | 52-37 | 2 | 33,293 | Bob Welch | Bill Gullickson | Bill Gullickson | Bob Welch | Kurt Knudsen | 410 | 382 | 28 |
| 1992-07-18 | vs DET | 90 | L 2-5 | 52-38 | 2 | 41,533 | Mike Moore | Mark Leiter | Mark Leiter | Mike Moore | Buddy Groom | 412 | 387 | 25 |
| 1992-07-19 | vs DET | 91 | W 6-2 | 53-38 | 2 | 31,429 | Gene Nelson | Kevin Ritz | Gene Nelson | Kevin Ritz | | 418 | 389 | 29 |
| 1992-07-20 | vs NYA | 92 | L 0-1 | 53-39 | 2 | 26,637 | Ron Darling | Shawn Hillegas | Shawn Hillegas | Ron Darling | | 418 | 390 | 28 |
| 1992-07-21 | vs NYA | 93 | L 1-5 | 53-40 | 2 | 26,573 | Kelly Downs | Melido Perez | Melido Perez | Kelly Downs | | 419 | 395 | 24 |
| 1992-07-22 | vs NYA | 94 | W 8-5 | 54-40 | 2 | 40,805 | Bob Welch | Scott Sanderson | Jeff Parrett | John Habyan | Dennis Eckersley | 427 | 400 | 27 |
| 1992-07-23 | vs TOR | 95 | L 3-9 | 54-41 | 2 | 24,707 | Mike Moore | Juan Guzman | Dave Stieb | Mike Moore | | 430 | 409 | 21 |
| 1992-07-24 | vs TOR | 96 | W 6-5 | 55-41 | 2 | 30,206 | Dave Stewart | David Wells | Dennis Eckersley | Tom Henke | | 436 | 414 | 22 |
| 1992-07-25 | vs TOR | 97 | W 6-0 | 56-41 | 2 | 36,086 | Ron Darling | Todd Stottlemyre | Ron Darling | Todd Stottlemyre | | 442 | 414 | 28 |
| 1992-07-26 | vs TOR | 98 | W 9-1 | 57-41 | 2 | 34,595 | Kelly Downs | Jack Morris | Kelly Downs | Jack Morris | | 451 | 415 | 36 |
| 1992-07-27 | @ MIN | 99 | W 9-1 | 58-41 | 2 | 47,677 | Bob Welch | John Smiley | Bob Welch | John Smiley | | 460 | 416 | 44 |
| 1992-07-28 | @ MIN | 100 | W 12-10 | 59-41 | 2 | 39,314 | Mike Moore | Scott Erickson | Gene Nelson | Tom Edens | Dennis Eckersley | 472 | 426 | 46 |
| 1992-07-29 | @ MIN | 101 | W 5-4 | 60-41 | 2 | 42,786 | Dave Stewart | Bill Krueger | Jeff Parrett | Rick Aguilera | Dennis Eckersley | 477 | 430 | 47 |
| 1992-07-31 | @ KCA | 102 | L 5-6 | 60-42 | 2 | 35,087 | Ron Darling | Rick Reed | Rusty Meacham | Jeff Parrett | | 482 | 436 | 46 |
| 1992-08-01 | @ KCA | 103 | L 4-8 | 60-43 | 2 | 30,892 | Kelly Downs | Hipolito Pichardo | Tom Gordon | Kelly Downs | | 486 | 444 | 42 |
| 1992-08-02 | @ KCA | 104 | W 8-4 | 61-43 | 2 | 34,139 | Bob Welch | Dennis Moeller | Bob Welch | Juan Berenguer | | 494 | 448 | 46 |
| 1992-08-03 | @ TEX | 105 | W 4-1 | 62-43 | 2 | 32,533 | Mike Moore | Jose Guzman | Mike Moore | Jose Guzman | Dennis Eckersley | 498 | 449 | 49 |
| 1992-08-04 | @ TEX | 106 | W 9-0 | 63-43 | 2 | 27,572 | Dave Stewart | Brian Bohanon | Dave Stewart | Brian Bohanon | Kevin Campbell | 507 | 449 | 58 |
| 1992-08-05 | @ TEX | 107 | W 4-3 | 64-43 | 1 | 27,606 | Ron Darling | Bobby Witt | Ron Darling | Bobby Witt | Dennis Eckersley | 511 | 452 | 59 |
| 1992-08-06 | @ TEX | 108 | W 2-0 | 65-43 | 1 | 36,712 | Kelly Downs | Nolan Ryan | Kelly Downs | Nolan Ryan | Rick Honeycutt | 513 | 452 | 61 |
| 1992-08-07 | vs KCA | 109 | W 8-6 | 66-43 | 1 | 30,112 | Bob Welch | Dennis Moeller | Bob Welch | Dennis Moeller | Dennis Eckersley | 521 | 458 | 63 |
| 1992-08-08 | vs KCA | 110 | W 5-3 | 67-43 | 1 | 30,783 | Mike Moore | Tom Gordon | Dennis Eckersley | Jeff Montgomery | | 526 | 461 | 65 |
| 1992-08-09 | vs KCA | 111 | L 2-5 | 67-44 | 1 | 30,477 | Dave Stewart | Kevin Appier | Kevin Appier | Dave Stewart | Jeff Montgomery | 528 | 466 | 62 |
| 1992-08-10 | vs CHA | 112 | W 5-3 | 68-44 | 1 | 31,374 | Ron Darling | Charlie Hough | Ron Darling | Charlie Hough | Dennis Eckersley | 533 | 469 | 64 |
| 1992-08-11 | vs CHA | 113 | L 6-10 | 68-45 | 1 | 27,550 | Kelly Downs | Kirk McCaskill | Roberto Hernandez | Rick Honeycutt | Scott Radinsky | 539 | 479 | 60 |
| 1992-08-12 | vs CHA | 114 | W 2-1 | 69-45 | 1 | 34,767 | Kevin Campbell | Jack McDowell | Dennis Eckersley | Jack McDowell | | 541 | 480 | 61 |
| 1992-08-13 | vs CAL | 115 | W 4-1 | 70-45 | 1 | 24,650 | Mike Moore | Jim Abbott | Mike Moore | Jim Abbott | | 545 | 481 | 64 |
| 1992-08-14 | vs CAL | 116 | L 1-2 | 70-46 | 1 | 28,882 | Dave Stewart | Bert Blyleven | Bert Blyleven | Dave Stewart | Joe Grahe | 546 | 483 | 63 |
| 1992-08-15 | vs CAL | 117 | W 9-5 | 71-46 | 1 | 33,149 | Ron Darling | Julio Valera | Jim Corsi | Chuck Crim | | 555 | 488 | 67 |
| 1992-08-16 | vs CAL | 118 | W 5-4 | 72-46 | 1 | 32,003 | Kelly Downs | Chuck Finley | Dennis Eckersley | Joe Grahe | | 560 | 492 | 68 |
| 1992-08-18 | @ NYA | 119 | L 3-7 | 72-47 | 1 | 20,669 | Mike Moore | Scott Sanderson | Scott Sanderson | Mike Moore | Steve Farr | 563 | 499 | 64 |
| 1992-08-19 | @ NYA | 120 | L 3-14 | 72-48 | 1 | 20,568 | Dave Stewart | Scott Kamieniecki | Scott Kamieniecki | Dave Stewart | | 566 | 513 | 53 |
| 1992-08-20 | @ NYA | 121 | W 8-6 | 73-48 | 1 | 29,671 | Ron Darling | Sam Militello | Jeff Parrett | Steve Farr | Dennis Eckersley | 574 | 519 | 55 |
| 1992-08-21 | @ BAL | 122 | L 2-4 | 73-49 | 1 | 45,909 | Kelly Downs | Mike Mussina | Mike Mussina | Kelly Downs | Alan Mills | 576 | 523 | 53 |
| 1992-08-22 | @ BAL | 123 | W 5-3 | 74-49 | 1 | 45,580 | Kevin Campbell | Richie Lewis | Jeff Parrett | Richie Lewis | Dennis Eckersley | 581 | 526 | 55 |
| 1992-08-23 | @ BAL | 124 | W 7-3 | 75-49 | 1 | 45,479 | Mike Moore | Ben McDonald | Mike Moore | Ben McDonald | Dennis Eckersley | 588 | 529 | 59 |
| 1992-08-24 | @ BOS | 125 | W 9-3 | 76-49 | 1 | 33,494 | Dave Stewart | John Dopson | Dave Stewart | John Dopson | | 597 | 532 | 65 |
| 1992-08-25 | @ BOS | 126 | L 4-5 | 76-50 | 1 | 33,387 | Ron Darling | Danny Darwin | Paul Quantrill | Dennis Eckersley | Jeff Reardon | 601 | 537 | 64 |
| 1992-08-26 | @ BOS | 127 | L 1-2 | 76-51 | 1 | 33,193 | Kelly Downs | Frank Viola | Frank Viola | Kevin Campbell | | 602 | 539 | 63 |
| 1992-08-28 | vs CLE | 128 | W 7-6 | 77-51 | 1 | 30,422 | Mike Moore | Jack Armstrong | Jim Corsi | Jack Armstrong | Dennis Eckersley | 609 | 545 | 64 |
| 1992-08-29 | vs CLE | 129 | W 4-1 | 78-51 | 1 | 35,036 | Dave Stewart | Jose Mesa | Dave Stewart | Jose Mesa | Dennis Eckersley | 613 | 546 | 67 |
| 1992-08-30 | vs CLE | 130 | W 7-5 | 79-51 | 1 | 37,524 | Ron Darling | Charles Nagy | Ron Darling | Charles Nagy | Rick Honeycutt | 620 | 551 | 69 |
| 1992-08-31 | vs BAL | 131 | L 0-4 | 79-52 | 1 | 25,442 | Kelly Downs | Mike Mussina | Mike Mussina | Kelly Downs | | 620 | 555 | 65 |
| 1992-09-01 | vs BAL | 132 | L 1-5 | 79-53 | 1 | 21,303 | Joe Slusarski | Bob Milacki | Bob Milacki | Joe Slusarski | | 621 | 560 | 61 |
| 1992-09-02 | vs BAL | 133 | L 1-2 | 79-54 | 1 | 25,313 | Mike Moore | Ben McDonald | Alan Mills | Rick Honeycutt | | 622 | 562 | 60 |
| 1992-09-04 | vs BOS | 134 | L 3-8 | 79-55 | 1 | 35,084 | Dave Stewart | Danny Darwin | Danny Darwin | Dave Stewart | | 625 | 570 | 55 |
| 1992-09-05 | vs BOS | 135 | L 3-7 | 79-56 | 1 | 32,610 | Ron Darling | John Dopson | John Dopson | Ron Darling | | 628 | 577 | 51 |
| 1992-09-06 | vs BOS | 136 | W 2-1 | 80-56 | 1 | 29,670 | Bobby Witt | Frank Viola | Dennis Eckersley | Paul Quantrill | | 630 | 578 | 52 |
| 1992-09-07 | @ CAL | 137 | L 2-3 | 80-57 | 1 | 21,251 | Mike Moore | Julio Valera | Julio Valera | Mike Moore | Joe Grahe | 632 | 581 | 51 |
| 1992-09-08 | @ CAL | 138 | W 14-2 | 81-57 | 1 | 18,904 | Kelly Downs | Chuck Finley | Kelly Downs | Chuck Finley | | 646 | 583 | 63 |
| 1992-09-09 | @ CAL | 139 | W 3-0 | 82-57 | 1 | 21,795 | Dave Stewart | Mark Langston | Dave Stewart | Mark Langston | Dennis Eckersley | 649 | 583 | 66 |
| 1992-09-10 | vs SEA | 140 | W 6-4 | 83-57 | 1 | 18,745 | Ron Darling | Randy Johnson | Ron Darling | Randy Johnson | Dennis Eckersley | 655 | 587 | 68 |
| 1992-09-11 | vs SEA | 141 | W 4-3 | 84-57 | 1 | 29,177 | Bobby Witt | Brian Fisher | Jeff Russell | Jeff Nelson | | 659 | 590 | 69 |
| 1992-09-12 | vs SEA | 142 | W 5-4 | 85-57 | 1 | 30,159 | Mike Moore | Tim Leary | Mike Moore | Tim Leary | Dennis Eckersley | 664 | 594 | 70 |
| 1992-09-13 | vs SEA | 143 | W 3-1 | 86-57 | 1 | 28,088 | Bob Welch | Erik Hanson | Kelly Downs | Erik Hanson | Jeff Russell | 667 | 595 | 72 |
| 1992-09-14 | vs MIN | 144 | W 3-2 | 87-57 | 1 | 30,236 | Dave Stewart | Kevin Tapani | Jim Corsi | Tom Edens | Dennis Eckersley | 670 | 597 | 73 |
| 1992-09-15 | vs MIN | 145 | W 2-1 | 88-57 | 1 | 30,424 | Ron Darling | Pat Mahomes | Ron Darling | Pat Mahomes | Dennis Eckersley | 672 | 598 | 74 |
| 1992-09-16 | vs MIN | 146 | W 4-2 | 89-57 | 1 | 35,348 | Bobby Witt | John Smiley | Bobby Witt | John Smiley | Jeff Russell | 676 | 600 | 76 |
| 1992-09-18 | @ SEA | 147 | W 7-4 | 90-57 | 1 | 39,508 | Mike Moore | Brian Fisher | Mike Moore | Brian Fisher | Dennis Eckersley | 683 | 604 | 79 |
| 1992-09-19 | @ SEA | 148 | L 4-6 | 90-58 | 1 | 17,517 | Bob Welch | Tim Leary | Tim Leary | Bob Welch | Jeff Nelson | 687 | 610 | 77 |
| 1992-09-20 | @ SEA | 149 | W 4-2 | 91-58 | 1 | 15,295 | Dave Stewart | Erik Hanson | Dave Stewart | Erik Hanson | Dennis Eckersley | 691 | 612 | 79 |
| 1992-09-21 | @ CHA | 150 | W 6-5 | 92-58 | 1 | 29,529 | Ron Darling | Alex Fernandez | Ron Darling | Alex Fernandez | Dennis Eckersley | 697 | 617 | 80 |
| 1992-09-22 | @ CHA | 151 | L 3-8 | 92-59 | 1 | 25,891 | Bobby Witt | Charlie Hough | Charlie Hough | Bobby Witt | | 700 | 625 | 75 |
| 1992-09-23 | @ CHA | 152 | L 6-17 | 92-60 | 1 | 26,279 | Mike Moore | Kirk McCaskill | Kirk McCaskill | Mike Moore | | 706 | 642 | 64 |
| 1992-09-24 | @ CHA | 153 | W 4-1 | 93-60 | 1 | 26,817 | Bob Welch | Jack McDowell | Bob Welch | Jack McDowell | Dennis Eckersley | 710 | 643 | 67 |
| 1992-09-25 | @ MIL | 154 | L 1-4 | 93-61 | 1 | 24,846 | Dave Stewart | Ricky Bones | Ricky Bones | Dave Stewart | | 711 | 647 | 64 |
| 1992-09-26 | @ MIL | 155 | L 1-2 | 93-62 | 1 | 26,509 | Ron Darling | Bill Wegman | Jesse Orosco | Ron Darling | Doug Henry | 712 | 649 | 63 |
| 1992-09-27 | @ MIL | 156 | L 3-5 | 93-63 | 1 | 54,985 | Bobby Witt | Jaime Navarro | Jaime Navarro | Kevin Campbell | Doug Henry | 715 | 654 | 61 |
| 1992-09-29 | vs TEX | 157 | W 5-0 | 94-63 | 1 | 37,069 | Mike Moore | Kevin Brown | Mike Moore | Kevin Brown | | 720 | 654 | 66 |
| 1992-09-30 | vs TEX | 158 | L 3-7 | 94-64 | 1 | 25,601 | Bob Welch | Jose Guzman | Jose Guzman | Bob Welch | Matt Whiteside | 723 | 661 | 62 |
| 1992-10-01 | vs TEX | 159 | L 3-4 | 94-65 | 1 | 29,210 | Dave Stewart | Roger Pavlik | Kenny Rogers | Vince Horsman | Matt Whiteside | 726 | 665 | 61 |
| 1992-10-02 | vs MIL | 160 | L 2-3 | 94-66 | 1 | 27,796 | Ron Darling | Jaime Navarro | Darren Holmes | Jim Corsi | Doug Henry | 728 | 668 | 60 |
| 1992-10-03 | vs MIL | 161 | W 10-3 | 95-66 | 1 | 29,040 | Mike Moore | Ricky Bones | Mike Moore | Ricky Bones | | 738 | 671 | 67 |
| 1992-10-04 | vs MIL | 162 | W 7-1 | 96-66 | 1 | 37,082 | Bobby Witt | Cal Eldred | Jeff Russell | Cal Eldred | | 745 | 672 | 73 |