| 1992-04-06 | @ OAK | 1 | L 3-5 | 0-1 | 5 | 44,078 | Kevin Appier | Dave Stewart | Rick Honeycutt | Luis Aquino | Dennis Eckersley | 3 | 5 | -2 |
| 1992-04-08 | @ OAK | 2 | L 3-4 | 0-2 | 5 | 42,421 | Tom Gordon | Mike Moore | Jeff Parrett | Neal Heaton | | 6 | 9 | -3 |
| 1992-04-09 | @ OAK | 3 | L 2-5 | 0-3 | 5 | 20,211 | Mark Gubicza | Ron Darling | Ron Darling | Mark Gubicza | Dennis Eckersley | 8 | 14 | -6 |
| 1992-04-10 | @ SEA | 4 | L 3-9 | 0-4 | 6 | 17,043 | Mark Davis | Rich DeLucia | Rich DeLucia | Mark Davis | | 11 | 23 | -12 |
| 1992-04-11 | @ SEA | 5 | L 0-1 | 0-5 | 7 | 46,595 | Kevin Appier | Randy Johnson | Randy Johnson | Kevin Appier | | 11 | 24 | -13 |
| 1992-04-12 | @ SEA | 6 | L 1-2 | 0-6 | 7 | 15,681 | Mike Boddicker | Erik Hanson | Erik Hanson | Mike Boddicker | Mike Schooler | 12 | 26 | -14 |
| 1992-04-13 | vs OAK | 7 | L 1-6 | 0-7 | 7 | 39,428 | Tom Gordon | Mike Moore | Mike Moore | Tom Gordon | | 13 | 32 | -19 |
| 1992-04-14 | vs OAK | 8 | W 3-1 | 1-7 | 7 | 17,321 | Mark Gubicza | Ron Darling | Neal Heaton | Rick Honeycutt | Jeff Montgomery | 16 | 33 | -17 |
| 1992-04-15 | vs OAK | 9 | L 6-10 | 1-8 | 7 | 16,519 | Mark Davis | Joe Slusarski | Jeff Parrett | Mike Magnante | Vince Horsman | 22 | 43 | -21 |
| 1992-04-16 | vs OAK | 10 | L 0-1 | 1-9 | 7 | 22,041 | Kevin Appier | Dave Stewart | Dave Stewart | Jeff Montgomery | Dennis Eckersley | 22 | 44 | -22 |
| 1992-04-17 | vs CAL | 11 | L 1-8 | 1-10 | 7 | 18,296 | Mike Boddicker | Scott Lewis | Scott Lewis | Mike Boddicker | | 23 | 52 | -29 |
| 1992-04-18 | vs CAL | 12 | L 3-5 | 1-11 | 7 | 20,129 | Tom Gordon | Jim Abbott | Steve Frey | Jeff Montgomery | | 26 | 57 | -31 |
| 1992-04-21 | vs BAL | 13 | L 4-10 | 1-12 | 7 | 15,258 | Mark Gubicza | Jose Mesa | Jose Mesa | Mark Gubicza | | 30 | 67 | -37 |
| 1992-04-22 | vs BAL | 14 | L 1-2 | 1-13 | 7 | 16,131 | Kevin Appier | Rick Sutcliffe | Rick Sutcliffe | Kevin Appier | | 31 | 69 | -38 |
| 1992-04-23 | vs BAL | 15 | L 1-8 | 1-14 | 7 | 20,495 | Mark Davis | Mike Mussina | Mike Mussina | Mark Davis | | 32 | 77 | -45 |
| 1992-04-24 | @ TOR | 16 | L 3-4 | 1-15 | 7 | 50,352 | Tom Gordon | Juan Guzman | Juan Guzman | Tom Gordon | Tom Henke | 35 | 81 | -46 |
| 1992-04-25 | @ TOR | 17 | L 4-6 | 1-16 | 7 | 50,346 | Mike Magnante | Jimmy Key | Pat Hentgen | Curt Young | Duane Ward | 39 | 87 | -48 |
| 1992-04-26 | @ TOR | 18 | W 9-0 | 2-16 | 7 | 46,486 | Mark Gubicza | Jack Morris | Mark Gubicza | Jack Morris | | 48 | 87 | -39 |
| 1992-04-28 | @ MIL | 19 | W 3-2 | 3-16 | 7 | 8,009 | Kevin Appier | Bill Wegman | Neal Heaton | Jesse Orosco | Jeff Montgomery | 51 | 89 | -38 |
| 1992-04-29 | @ MIL | 20 | L 3-5 | 3-17 | 7 | 9,779 | Tom Gordon | Ricky Bones | Ricky Bones | Tom Gordon | Doug Henry | 54 | 94 | -40 |
| 1992-05-01 | @ BOS | 21 | L 5-6 | 3-18 | 7 | 27,973 | Mark Gubicza | Mike Gardiner | Danny Darwin | Jeff Montgomery | | 59 | 100 | -41 |
| 1992-05-02 | @ BOS | 22 | L 6-7 | 3-19 | 7 | 31,978 | Mark Davis | Matt Young | Greg Harris | Hipolito Pichardo | Jeff Reardon | 65 | 107 | -42 |
| 1992-05-03 | @ BOS | 23 | W 5-2 | 4-19 | 7 | 33,368 | Kevin Appier | Joe Hesketh | Kevin Appier | Joe Hesketh | Jeff Montgomery | 70 | 109 | -39 |
| 1992-05-04 | @ CLE | 24 | W 11-6 | 5-19 | 7 | 3,930 | Tom Gordon | Dave Otto | Rusty Meacham | Rod Nichols | | 81 | 115 | -34 |
| 1992-05-05 | @ CLE | 25 | L 6-8 | 5-20 | 7 | 5,021 | Mike Magnante | Jack Armstrong | Jack Armstrong | Mike Magnante | Steve Olin | 87 | 123 | -36 |
| 1992-05-06 | vs MIL | 26 | W 3-1 | 6-20 | 7 | 17,271 | Mark Gubicza | Jaime Navarro | Mark Gubicza | Jaime Navarro | Jeff Montgomery | 90 | 124 | -34 |
| 1992-05-07 | vs MIL | 27 | W 6-4 | 7-20 | 7 | 21,518 | Curt Young | Dan Plesac | Curt Young | Dan Plesac | Jeff Montgomery | 96 | 128 | -32 |
| 1992-05-08 | vs BOS | 28 | W 2-1 | 8-20 | 7 | 22,063 | Kevin Appier | Joe Hesketh | Kevin Appier | Joe Hesketh | Jeff Montgomery | 98 | 129 | -31 |
| 1992-05-09 | vs BOS | 29 | L 0-5 | 8-21 | 7 | 28,444 | Tom Gordon | Roger Clemens | Roger Clemens | Tom Gordon | | 98 | 134 | -36 |
| 1992-05-10 | vs BOS | 30 | L 6-10 | 8-22 | 7 | 19,180 | Mike Magnante | Frank Viola | Frank Viola | Mike Magnante | | 104 | 144 | -40 |
| 1992-05-12 | vs CLE | 31 | W 3-0 | 9-22 | 7 | 18,480 | Mark Gubicza | Scott Scudder | Mark Gubicza | Scott Scudder | | 107 | 144 | -37 |
| 1992-05-13 | vs CLE | 32 | W 5-3 | 10-22 | 7 | 17,252 | Kevin Appier | Dennis Cook | Kevin Appier | Dennis Cook | Jeff Montgomery | 112 | 147 | -35 |
| 1992-05-15 | vs DET | 33 | L 2-8 | 10-23 | 7 | 22,844 | Curt Young | Bill Gullickson | John Doherty | Curt Young | | 114 | 155 | -41 |
| 1992-05-16 | vs DET | 34 | L 2-7 | 10-24 | 7 | 32,460 | Tom Gordon | Scott Aldred | Scott Aldred | Tom Gordon | | 116 | 162 | -46 |
| 1992-05-17 | vs DET | 35 | W 2-1 | 11-24 | 7 | 20,642 | Mark Gubicza | Mark Leiter | Mark Gubicza | Walt Terrell | | 118 | 163 | -45 |
| 1992-05-18 | @ CHA | 36 | W 6-1 | 12-24 | 7 | 25,434 | Mike Magnante | Kirk McCaskill | Mike Magnante | Kirk McCaskill | | 124 | 164 | -40 |
| 1992-05-19 | @ CHA | 37 | L 1-2 | 12-25 | 7 | 26,510 | Kevin Appier | Charlie Hough | Charlie Hough | Kevin Appier | Bobby Thigpen | 125 | 166 | -41 |
| 1992-05-20 | @ CHA | 38 | W 7-2 | 13-25 | 7 | 29,250 | Hipolito Pichardo | Alex Fernandez | Hipolito Pichardo | Alex Fernandez | Mike Boddicker | 132 | 168 | -36 |
| 1992-05-21 | @ TEX | 39 | W 7-5 | 14-25 | 7 | 21,363 | Tom Gordon | Nolan Ryan | Rusty Meacham | Kenny Rogers | Jeff Montgomery | 139 | 173 | -34 |
| 1992-05-22 | @ TEX | 40 | L 7-10 | 14-26 | 7 | 34,385 | Mark Gubicza | Bobby Witt | Bobby Witt | Mark Gubicza | | 146 | 183 | -37 |
| 1992-05-23 | @ TEX | 41 | L 2-4 | 14-27 | 7 | 33,347 | Mike Magnante | Kevin Brown | Kevin Brown | Mike Magnante | | 148 | 187 | -39 |
| 1992-05-24 | @ TEX | 42 | L 3-4 | 14-28 | 7 | 28,059 | Kevin Appier | Mike Jeffcoat | Gerald Alexander | Tom Gordon | | 151 | 191 | -40 |
| 1992-05-26 | @ DET | 43 | L 1-8 | 14-29 | 7 | 10,290 | Hipolito Pichardo | Bill Gullickson | Bill Gullickson | Hipolito Pichardo | | 152 | 199 | -47 |
| 1992-05-27 | @ DET | 44 | L 2-11 | 14-30 | 7 | 10,622 | Mike Boddicker | Scott Aldred | Scott Aldred | Mike Boddicker | | 154 | 210 | -56 |
| 1992-05-28 | @ DET | 45 | W 5-1 | 15-30 | 7 | 11,688 | Mark Gubicza | Mark Leiter | Mark Gubicza | Mark Leiter | | 159 | 211 | -52 |
| 1992-05-29 | vs TEX | 46 | L 3-5 | 15-31 | 7 | 20,591 | Mike Magnante | Kevin Brown | Kevin Brown | Jeff Montgomery | | 162 | 216 | -54 |
| 1992-05-30 | vs TEX | 47 | W 8-2 | 16-31 | 7 | 25,657 | Kevin Appier | Mike Jeffcoat | Kevin Appier | Mike Jeffcoat | | 170 | 218 | -48 |
| 1992-05-31 | vs TEX | 48 | W 7-6 | 17-31 | 7 | 21,681 | Hipolito Pichardo | Jose Guzman | Rusty Meacham | Jeff Russell | | 177 | 224 | -47 |
| 1992-06-01 | vs CHA | 49 | L 3-5 | 17-32 | 7 | 25,297 | Mike Boddicker | Alex Fernandez | Alex Fernandez | Mike Boddicker | | 180 | 229 | -49 |
| 1992-06-02 | vs CHA | 50 | W 2-1 | 18-32 | 7 | 18,203 | Mark Gubicza | Jack McDowell | Mark Gubicza | Scott Radinsky | Jeff Montgomery | 182 | 230 | -48 |
| 1992-06-03 | vs CHA | 51 | W 3-1 | 19-32 | 7 | 19,218 | Mike Magnante | Greg Hibbard | Mike Magnante | Greg Hibbard | Jeff Montgomery | 185 | 231 | -46 |
| 1992-06-05 | vs SEA | 52 | W 6-4 | 20-32 | 7 | 25,023 | Kevin Appier | Calvin Jones | Kevin Appier | Calvin Jones | Jeff Montgomery | 191 | 235 | -44 |
| 1992-06-06 | vs SEA | 53 | W 4-3 | 21-32 | 7 | 24,111 | Hipolito Pichardo | Randy Kramer | Neal Heaton | Mike Schooler | | 195 | 238 | -43 |
| 1992-06-07 | vs SEA | 54 | W 4-1 | 22-32 | 5 | 21,866 | Mike Boddicker | Erik Hanson | Rick Reed | Erik Hanson | Jeff Montgomery | 199 | 239 | -40 |
| 1992-06-08 | vs MIN | 55 | W 9-6 | 23-32 | 5 | 26,119 | Mark Gubicza | Kevin Tapani | Tom Gordon | Bob Kipper | Jeff Montgomery | 208 | 245 | -37 |
| 1992-06-09 | vs MIN | 56 | L 2-4 | 23-33 | 5 | 25,171 | Mike Magnante | Bill Krueger | Bill Krueger | Mike Magnante | Rick Aguilera | 210 | 249 | -39 |
| 1992-06-10 | vs MIN | 57 | W 7-6 | 24-33 | 5 | 19,347 | Kevin Appier | Willie Banks | Rusty Meacham | Mark Guthrie | Jeff Montgomery | 217 | 255 | -38 |
| 1992-06-12 | @ CAL | 58 | L 0-5 | 24-34 | 5 | 40,407 | Hipolito Pichardo | Mark Langston | Mark Langston | Hipolito Pichardo | | 217 | 260 | -43 |
| 1992-06-13 | @ CAL | 59 | L 4-5 | 24-35 | 6 | 26,635 | Rick Reed | Chuck Finley | Chuck Finley | Rick Reed | Mark Eichhorn | 221 | 265 | -44 |
| 1992-06-14 | @ CAL | 60 | L 1-5 | 24-36 | 6 | 39,902 | Mark Gubicza | Julio Valera | Julio Valera | Mark Gubicza | Steve Frey | 222 | 270 | -48 |
| 1992-06-15 | @ MIN | 61 | W 7-0 | 25-36 | 6 | 21,614 | Mike Magnante | Bill Krueger | Mike Magnante | Bill Krueger | | 229 | 270 | -41 |
| 1992-06-16 | @ MIN | 62 | W 7-5 | 26-36 | 6 | 21,116 | Kevin Appier | Willie Banks | Kevin Appier | Bob Kipper | Jeff Montgomery | 236 | 275 | -39 |
| 1992-06-17 | @ MIN | 63 | L 2-4 | 26-37 | 7 | 19,199 | Hipolito Pichardo | John Smiley | Rick Aguilera | Tom Gordon | | 238 | 279 | -41 |
| 1992-06-18 | @ MIN | 64 | L 1-3 | 26-38 | 7 | 23,315 | Rick Reed | Scott Erickson | Scott Erickson | Rick Reed | Rick Aguilera | 239 | 282 | -43 |
| 1992-06-19 | vs TOR | 65 | W 11-4 | 27-38 | 7 | 23,942 | Mark Gubicza | Todd Stottlemyre | Mark Gubicza | Todd Stottlemyre | | 250 | 286 | -36 |
| 1992-06-20 | vs TOR | 66 | L 1-6 | 27-39 | 7 | 29,194 | Mike Magnante | Juan Guzman | Juan Guzman | Mike Magnante | | 251 | 292 | -41 |
| 1992-06-21 | vs TOR | 67 | W 2-0 | 28-39 | 7 | 24,275 | Kevin Appier | Jimmy Key | Kevin Appier | Jimmy Key | Jeff Montgomery | 253 | 292 | -39 |
| 1992-06-23 | vs NYA | 68 | W 2-1 | 29-39 | 6 | 23,157 | Hipolito Pichardo | Melido Perez | Hipolito Pichardo | Melido Perez | Jeff Montgomery | 255 | 293 | -38 |
| 1992-06-24 | vs NYA | 69 | L 3-6 | 29-40 | 6 | 23,277 | Rick Reed | Jeff Johnson | Jeff Johnson | Rick Reed | Steve Farr | 258 | 299 | -41 |
| 1992-06-25 | vs NYA | 70 | L 3-4 | 29-41 | 7 | 28,200 | Mark Gubicza | Scott Sanderson | Scott Sanderson | Mark Gubicza | Steve Farr | 261 | 303 | -42 |
| 1992-06-26 | @ BAL | 71 | L 5-6 | 29-42 | 7 | 45,710 | Mike Magnante | Ben McDonald | Todd Frohwirth | Rusty Meacham | Gregg Olson | 266 | 309 | -43 |
| 1992-06-27 | @ BAL | 72 | W 2-0 | 30-42 | 6 | 45,994 | Kevin Appier | Mike Mussina | Kevin Appier | Mike Mussina | Jeff Montgomery | 268 | 309 | -41 |
| 1992-06-28 | @ BAL | 73 | W 9-2 | 31-42 | 6 | 45,862 | Hipolito Pichardo | Jose Mesa | Hipolito Pichardo | Jose Mesa | Mike Boddicker | 277 | 311 | -34 |
| 1992-06-29 | @ NYA | 74 | W 7-3 | 32-42 | 5 | 16,860 | Mark Davis | Jeff Johnson | Mark Davis | Jeff Johnson | Jeff Montgomery | 284 | 314 | -30 |
| 1992-06-30 | @ NYA | 75 | L 0-6 | 32-43 | 5 | 17,318 | Mark Gubicza | Scott Sanderson | Scott Sanderson | Mark Gubicza | | 284 | 320 | -36 |
| 1992-07-01 | @ NYA | 76 | L 6-7 | 32-44 | 5 | 21,492 | Mike Magnante | Tim Leary | Greg Cadaret | Tom Gordon | John Habyan | 290 | 327 | -37 |
| 1992-07-02 | vs MIL | 77 | W 8-2 | 33-44 | 5 | 23,558 | Kevin Appier | Ron Robinson | Kevin Appier | Ron Robinson | | 298 | 329 | -31 |
| 1992-07-03 | vs MIL | 78 | L 3-7 | 33-45 | 5 | 40,309 | Hipolito Pichardo | Jaime Navarro | Jaime Navarro | Hipolito Pichardo | | 301 | 336 | -35 |
| 1992-07-05 | vs MIL | 79 | L 1-2 | 33-47 | 5 | 0 | Mark Gubicza | Chris Bosio | Mike Fetters | Jeff Montgomery | Doug Henry | 302 | 338 | -36 |
| 1992-07-05 | vs MIL | 80 | L 7-9 | 33-47 | 5 | 25,835 | Mark Davis | Ricky Bones | Ricky Bones | Mark Davis | Darren Holmes | 309 | 347 | -38 |
| 1992-07-06 | @ BOS | 81 | W 6-3 | 34-47 | 5 | 28,495 | Rick Reed | John Dopson | Rick Reed | John Dopson | Rusty Meacham | 315 | 350 | -35 |
| 1992-07-07 | @ BOS | 82 | L 2-3 | 34-48 | 5 | 30,078 | Kevin Appier | Greg Harris | Danny Darwin | Rusty Meacham | | 317 | 353 | -36 |
| 1992-07-08 | @ BOS | 83 | L 4-5 | 34-49 | 5 | 31,196 | Hipolito Pichardo | Frank Viola | Tony Fossas | Tom Gordon | Jeff Reardon | 321 | 358 | -37 |
| 1992-07-09 | @ MIL | 84 | W 3-2 | 35-49 | 5 | 18,573 | Mike Boddicker | Chris Bosio | Steve Shifflett | Chris Bosio | Jeff Montgomery | 324 | 360 | -36 |
| 1992-07-10 | @ MIL | 85 | W 3-1 | 36-49 | 5 | 22,594 | Mark Gubicza | Ricky Bones | Tom Gordon | Ricky Bones | Jeff Montgomery | 327 | 361 | -34 |
| 1992-07-11 | @ MIL | 86 | L 1-5 | 36-50 | 5 | 30,838 | Rick Reed | Bill Wegman | Bill Wegman | Rick Reed | | 328 | 366 | -38 |
| 1992-07-12 | @ MIL | 87 | W 5-1 | 37-50 | 5 | 31,080 | Kevin Appier | Bruce Ruffin | Kevin Appier | Bruce Ruffin | Mike Boddicker | 333 | 367 | -34 |
| 1992-07-16 | vs CLE | 88 | W 3-2 | 38-50 | 5 | 25,080 | Hipolito Pichardo | Jose Mesa | Hipolito Pichardo | Jose Mesa | Jeff Montgomery | 336 | 369 | -33 |
| 1992-07-17 | vs CLE | 89 | W 4-3 | 39-50 | 5 | 28,033 | Rick Reed | Charles Nagy | Jeff Montgomery | Eric Plunk | | 340 | 372 | -32 |
| 1992-07-18 | vs CLE | 90 | W 4-1 | 40-50 | 5 | 29,000 | Kevin Appier | Jack Armstrong | Kevin Appier | Jack Armstrong | Rusty Meacham | 344 | 373 | -29 |
| 1992-07-19 | vs CLE | 91 | L 3-4 | 40-51 | 5 | 21,637 | Luis Aquino | Scott Scudder | Derek Lilliquist | Steve Shifflett | Steve Olin | 347 | 377 | -30 |
| 1992-07-20 | vs BOS | 92 | L 3-5 | 40-52 | 5 | 30,260 | Mike Boddicker | Danny Darwin | Paul Quantrill | Steve Shifflett | Jeff Reardon | 350 | 382 | -32 |
| 1992-07-21 | vs BOS | 93 | W 8-0 | 41-52 | 5 | 21,921 | Hipolito Pichardo | Joe Hesketh | Hipolito Pichardo | Joe Hesketh | | 358 | 382 | -24 |
| 1992-07-22 | vs BOS | 94 | W 6-4 | 42-52 | 5 | 22,978 | Rick Reed | Frank Viola | Tom Gordon | Frank Viola | Jeff Montgomery | 364 | 386 | -22 |
| 1992-07-23 | @ CLE | 95 | L 0-1 | 42-53 | 5 | 8,788 | Kevin Appier | Rod Nichols | Kevin Wickander | Mike Magnante | | 364 | 387 | -23 |
| 1992-07-24 | @ CLE | 96 | W 8-3 | 43-53 | 5 | 10,824 | Luis Aquino | Scott Scudder | Luis Aquino | Scott Scudder | Jeff Montgomery | 372 | 390 | -18 |
| 1992-07-25 | @ CLE | 97 | L 5-6 | 43-54 | 5 | 15,779 | Mike Boddicker | Dennis Cook | Steve Olin | Rusty Meacham | | 377 | 396 | -19 |
| 1992-07-26 | @ CLE | 98 | L 1-2 | 43-55 | 5 | 22,239 | Hipolito Pichardo | Jose Mesa | Steve Olin | Steve Shifflett | | 378 | 398 | -20 |
| 1992-07-28 | @ TOR | 99 | L 4-6 | 43-56 | 6 | 50,392 | Dennis Moeller | Jimmy Key | Jimmy Key | Dennis Moeller | Tom Henke | 382 | 404 | -22 |
| 1992-07-29 | @ TOR | 100 | W 5-2 | 44-56 | 5 | 50,418 | Kevin Appier | Dave Stieb | Kevin Appier | Mike Timlin | Jeff Montgomery | 387 | 406 | -19 |
| 1992-07-30 | @ TOR | 101 | L 0-3 | 44-57 | 6 | 50,417 | Luis Aquino | David Wells | David Wells | Luis Aquino | Tom Henke | 387 | 409 | -22 |
| 1992-07-31 | vs OAK | 102 | W 6-5 | 45-57 | 6 | 35,087 | Rick Reed | Ron Darling | Rusty Meacham | Jeff Parrett | | 393 | 414 | -21 |
| 1992-08-01 | vs OAK | 103 | W 8-4 | 46-57 | 6 | 30,892 | Hipolito Pichardo | Kelly Downs | Tom Gordon | Kelly Downs | | 401 | 418 | -17 |
| 1992-08-02 | vs OAK | 104 | L 4-8 | 46-58 | 6 | 34,139 | Dennis Moeller | Bob Welch | Bob Welch | Juan Berenguer | | 405 | 426 | -21 |
| 1992-08-04 | vs CAL | 105 | L 1-5 | 47-59 | 6 | 0 | Kevin Appier | Bert Blyleven | Bert Blyleven | Kevin Appier | Chuck Crim | 406 | 431 | -25 |
| 1992-08-04 | vs CAL | 106 | W 4-1 | 47-59 | 6 | 25,576 | Luis Aquino | Tim Fortugno | Luis Aquino | Tim Fortugno | | 410 | 432 | -22 |
| 1992-08-05 | vs CAL | 107 | W 5-2 | 48-59 | 5 | 24,300 | Rick Reed | Julio Valera | Tom Gordon | Julio Valera | Jeff Montgomery | 415 | 434 | -19 |
| 1992-08-06 | vs CAL | 108 | W 7-6 | 49-59 | 5 | 22,553 | Hipolito Pichardo | Chuck Finley | Juan Berenguer | Chuck Crim | Jeff Montgomery | 422 | 440 | -18 |
| 1992-08-07 | @ OAK | 109 | L 6-8 | 49-60 | 5 | 30,112 | Dennis Moeller | Bob Welch | Bob Welch | Dennis Moeller | Dennis Eckersley | 428 | 448 | -20 |
| 1992-08-08 | @ OAK | 110 | L 3-5 | 49-61 | 5 | 30,783 | Tom Gordon | Mike Moore | Dennis Eckersley | Jeff Montgomery | | 431 | 453 | -22 |
| 1992-08-09 | @ OAK | 111 | W 5-2 | 50-61 | 5 | 30,477 | Kevin Appier | Dave Stewart | Kevin Appier | Dave Stewart | Jeff Montgomery | 436 | 455 | -19 |
| 1992-08-10 | @ SEA | 112 | L 1-3 | 50-62 | 5 | 24,889 | Luis Aquino | Randy Johnson | Randy Johnson | Luis Aquino | | 437 | 458 | -21 |
| 1992-08-11 | @ SEA | 113 | W 9-6 | 51-62 | 5 | 12,691 | Hipolito Pichardo | Erik Hanson | Hipolito Pichardo | Erik Hanson | Jeff Montgomery | 446 | 464 | -18 |
| 1992-08-12 | @ SEA | 114 | L 3-6 | 51-63 | 6 | 15,983 | Dennis Moeller | Dave Fleming | Dave Fleming | Dennis Moeller | Jeff Nelson | 449 | 470 | -21 |
| 1992-08-14 | vs BAL | 115 | L 1-3 | 51-64 | 6 | 35,034 | Kevin Appier | Rick Sutcliffe | Rick Sutcliffe | Kevin Appier | Gregg Olson | 450 | 473 | -23 |
| 1992-08-15 | vs BAL | 116 | W 5-4 | 52-64 | 6 | 40,249 | Luis Aquino | Mike Mussina | Rusty Meacham | Gregg Olson | | 455 | 477 | -22 |
| 1992-08-16 | vs BAL | 117 | W 15-2 | 53-64 | 5 | 26,290 | Hipolito Pichardo | Alan Mills | Hipolito Pichardo | Alan Mills | | 470 | 479 | -9 |
| 1992-08-17 | vs DET | 118 | W 6-5 | 54-64 | 5 | 28,927 | Rick Reed | Bill Gullickson | Rusty Meacham | Kurt Knudsen | Jeff Montgomery | 476 | 484 | -8 |
| 1992-08-18 | vs DET | 119 | L 1-5 | 54-65 | 5 | 20,358 | Juan Berenguer | Eric King | Eric King | Juan Berenguer | | 477 | 489 | -12 |
| 1992-08-19 | vs DET | 120 | W 7-2 | 55-65 | 5 | 23,507 | Kevin Appier | Dave Haas | Kevin Appier | Dave Haas | | 484 | 491 | -7 |
| 1992-08-21 | @ CHA | 121 | W 4-3 | 56-65 | 5 | 31,761 | Luis Aquino | Kirk McCaskill | Rusty Meacham | Kirk McCaskill | Jeff Montgomery | 488 | 494 | -6 |
| 1992-08-22 | @ CHA | 122 | L 2-3 | 56-66 | 5 | 41,344 | Hipolito Pichardo | Greg Hibbard | Greg Hibbard | Hipolito Pichardo | Scott Radinsky | 490 | 497 | -7 |
| 1992-08-23 | @ CHA | 123 | L 1-3 | 56-67 | 6 | 37,112 | Rick Reed | Jack McDowell | Jack McDowell | Rick Reed | | 491 | 500 | -9 |
| 1992-08-25 | @ TEX | 124 | L 2-6 | 56-68 | 6 | 26,586 | Kevin Appier | Jose Guzman | Jose Guzman | Kevin Appier | | 493 | 506 | -13 |
| 1992-08-26 | @ TEX | 125 | L 1-3 | 56-69 | 6 | 20,054 | Luis Aquino | Roger Pavlik | Roger Pavlik | Rich Sauveur | Jeff Russell | 494 | 509 | -15 |
| 1992-08-27 | @ TEX | 126 | W 7-2 | 57-69 | 6 | 18,993 | Hipolito Pichardo | Nolan Ryan | Hipolito Pichardo | Nolan Ryan | | 501 | 511 | -10 |
| 1992-08-28 | @ DET | 127 | L 2-4 | 57-70 | 6 | 24,715 | Rick Reed | Frank Tanana | Walt Terrell | Rusty Meacham | Mike Henneman | 503 | 515 | -12 |
| 1992-08-29 | @ DET | 128 | L 1-12 | 57-71 | 6 | 41,605 | Juan Berenguer | Bill Gullickson | Bill Gullickson | Juan Berenguer | | 504 | 527 | -23 |
| 1992-08-30 | @ DET | 129 | W 9-4 | 58-71 | 6 | 24,667 | Kevin Appier | Eric King | Kevin Appier | Eric King | | 513 | 531 | -18 |
| 1992-08-31 | vs TEX | 130 | W 5-2 | 59-71 | 5 | 21,991 | Chris Haney | Roger Pavlik | Chris Haney | Roger Pavlik | Jeff Montgomery | 518 | 533 | -15 |
| 1992-09-01 | vs TEX | 131 | W 8-3 | 60-71 | 5 | 21,374 | Hipolito Pichardo | Nolan Ryan | Mike Boddicker | Todd Burns | | 526 | 536 | -10 |
| 1992-09-02 | vs TEX | 132 | L 2-6 | 60-72 | 6 | 15,784 | Rick Reed | Kevin Brown | Kevin Brown | Rick Reed | | 528 | 542 | -14 |
| 1992-09-03 | vs CHA | 133 | L 3-7 | 60-73 | 6 | 18,867 | Luis Aquino | Jack McDowell | Jack McDowell | Luis Aquino | | 531 | 549 | -18 |
| 1992-09-04 | vs CHA | 134 | L 0-8 | 60-74 | 6 | 18,513 | Kevin Appier | Alex Fernandez | Alex Fernandez | Kevin Appier | | 531 | 557 | -26 |
| 1992-09-05 | vs CHA | 135 | L 6-12 | 60-75 | 6 | 26,845 | Chris Haney | Charlie Hough | Wilson Alvarez | Juan Berenguer | | 537 | 569 | -32 |
| 1992-09-06 | vs CHA | 136 | W 3-2 | 61-75 | 6 | 25,166 | Ed Pierce | Kirk McCaskill | Tom Gordon | Roberto Hernandez | Jeff Montgomery | 540 | 571 | -31 |
| 1992-09-07 | vs TOR | 137 | W 5-4 | 62-75 | 6 | 21,015 | Rick Reed | Jack Morris | Mike Magnante | David Wells | | 545 | 575 | -30 |
| 1992-09-08 | vs TOR | 138 | L 0-5 | 62-76 | 6 | 15,454 | Luis Aquino | Jimmy Key | Jimmy Key | Luis Aquino | | 545 | 580 | -35 |
| 1992-09-09 | vs TOR | 139 | L 0-1 | 62-77 | 6 | 17,730 | Kevin Appier | David Cone | David Cone | Kevin Appier | Tom Henke | 545 | 581 | -36 |
| 1992-09-11 | @ NYA | 140 | L 1-2 | 62-78 | 6 | 15,597 | Chris Haney | Sterling Hitchcock | Rich Monteleone | Mike Magnante | Steve Farr | 546 | 583 | -37 |
| 1992-09-12 | @ NYA | 141 | L 9-11 | 62-79 | 6 | 18,566 | Hipolito Pichardo | Scott Kamieniecki | John Habyan | Mike Magnante | Steve Farr | 555 | 594 | -39 |
| 1992-09-13 | @ NYA | 142 | W 3-0 | 63-79 | 6 | 21,319 | Dennis Rasmussen | Melido Perez | Dennis Rasmussen | Melido Perez | Jeff Montgomery | 558 | 594 | -36 |
| 1992-09-14 | @ BAL | 143 | L 1-2 | 63-80 | 6 | 45,073 | Rick Reed | Rick Sutcliffe | Rick Sutcliffe | Rick Reed | Gregg Olson | 559 | 596 | -37 |
| 1992-09-15 | @ BAL | 144 | L 1-2 | 63-81 | 6 | 41,146 | Luis Aquino | Arthur Rhodes | Storm Davis | Bill Sampen | | 560 | 598 | -38 |
| 1992-09-16 | @ BAL | 145 | L 0-3 | 63-82 | 6 | 44,050 | Chris Haney | Mike Mussina | Mike Mussina | Chris Haney | | 560 | 601 | -41 |
| 1992-09-18 | vs NYA | 146 | W 3-2 | 64-82 | 6 | 20,310 | Hipolito Pichardo | Scott Kamieniecki | Hipolito Pichardo | Scott Kamieniecki | Jeff Montgomery | 563 | 603 | -40 |
| 1992-09-19 | vs NYA | 147 | W 7-4 | 65-82 | 6 | 23,903 | Dennis Rasmussen | Melido Perez | Dennis Rasmussen | Melido Perez | Jeff Montgomery | 570 | 607 | -37 |
| 1992-09-20 | vs NYA | 148 | L 4-10 | 65-83 | 6 | 23,982 | Rick Reed | Bob Wickman | Bob Wickman | Tom Gordon | Greg Cadaret | 574 | 617 | -43 |
| 1992-09-21 | vs SEA | 149 | W 3-0 | 66-83 | 6 | 17,105 | Luis Aquino | Dave Fleming | Luis Aquino | Dave Fleming | Jeff Montgomery | 577 | 617 | -40 |
| 1992-09-22 | vs SEA | 150 | W 3-0 | 67-83 | 5 | 16,172 | Chris Haney | Randy Johnson | Chris Haney | Randy Johnson | | 580 | 617 | -37 |
| 1992-09-23 | vs SEA | 151 | L 1-6 | 67-84 | 5 | 15,338 | Hipolito Pichardo | Brian Fisher | Brian Fisher | Hipolito Pichardo | | 581 | 623 | -42 |
| 1992-09-24 | vs SEA | 152 | W 2-0 | 68-84 | 5 | 17,915 | Dennis Rasmussen | Tim Leary | Dennis Rasmussen | Tim Leary | Jeff Montgomery | 583 | 623 | -40 |
| 1992-09-25 | @ MIN | 153 | W 4-3 | 69-84 | 5 | 22,699 | Rick Reed | Scott Erickson | Rusty Meacham | Scott Erickson | Jeff Montgomery | 587 | 626 | -39 |
| 1992-09-26 | @ MIN | 154 | L 2-9 | 69-85 | 5 | 33,502 | Luis Aquino | Kevin Tapani | Kevin Tapani | Luis Aquino | | 589 | 635 | -46 |
| 1992-09-27 | @ MIN | 155 | L 0-4 | 69-86 | 5 | 22,388 | Chris Haney | John Smiley | John Smiley | Chris Haney | | 589 | 639 | -50 |
| 1992-09-28 | @ CAL | 156 | L 5-6 | 69-87 | 5 | 19,916 | Hipolito Pichardo | Jim Abbott | Scott Lewis | Steve Shifflett | | 594 | 645 | -51 |
| 1992-09-29 | @ CAL | 157 | W 2-0 | 70-87 | 5 | 17,440 | Dennis Rasmussen | Bert Blyleven | Dennis Rasmussen | Bert Blyleven | | 596 | 645 | -49 |
| 1992-09-30 | @ CAL | 158 | W 4-0 | 71-87 | 5 | 17,336 | Rick Reed | Julio Valera | Rick Reed | Julio Valera | | 600 | 645 | -45 |
| 1992-10-01 | @ CAL | 159 | L 2-5 | 71-88 | 5 | 16,867 | Bill Sampen | Chuck Finley | Chuck Finley | Bill Sampen | Steve Frey | 602 | 650 | -48 |
| 1992-10-02 | vs MIN | 160 | L 1-5 | 71-89 | 5 | 24,590 | Chris Haney | John Smiley | John Smiley | Chris Haney | | 603 | 655 | -52 |
| 1992-10-03 | vs MIN | 161 | W 7-6 | 72-89 | 5 | 36,958 | Tom Gordon | Pat Mahomes | Rusty Meacham | Gary Wayne | | 610 | 661 | -51 |
| 1992-10-04 | vs MIN | 162 | L 0-6 | 72-90 | 5 | 23,053 | Dennis Rasmussen | Mike Trombley | Mike Trombley | Dennis Rasmussen | | 610 | 667 | -57 |