| 1991-04-08 | @ KCA | 1 | L 2-4 | 0-1 | 5 | 39,363 | Greg Swindell | Bret Saberhagen | Bret Saberhagen | Greg Swindell | Jeff Montgomery | 2 | 4 | -2 |
| 1991-04-09 | @ KCA | 2 | W 2-1 | 1-1 | 4 | 19,015 | Tom Candiotti | Mike Boddicker | Tom Candiotti | Mike Boddicker | Doug Jones | 4 | 5 | -1 |
| 1991-04-10 | @ KCA | 3 | L 0-1 | 1-2 | 6 | 18,428 | Charles Nagy | Kevin Appier | Kevin Appier | Charles Nagy | Jeff Montgomery | 4 | 6 | -2 |
| 1991-04-11 | @ BOS | 4 | W 6-4 | 2-2 | 4 | 34,134 | Eric King | Danny Darwin | Eric King | Danny Darwin | Doug Jones | 10 | 10 | 0 |
| 1991-04-13 | @ BOS | 5 | L 0-4 | 2-3 | 5 | 33,212 | Greg Swindell | Roger Clemens | Roger Clemens | Greg Swindell | | 10 | 14 | -4 |
| 1991-04-14 | @ BOS | 6 | W 6-0 | 3-3 | 2 | 33,348 | Tom Candiotti | Greg Harris | Tom Candiotti | Greg Harris | | 16 | 14 | 2 |
| 1991-04-15 | @ BOS | 7 | W 1-0 | 4-3 | 2 | 33,205 | Charles Nagy | Matt Young | Steve Olin | Dennis Lamp | Doug Jones | 17 | 14 | 3 |
| 1991-04-16 | vs TEX | 8 | L 1-3 | 4-4 | 3 | 46,606 | Eric King | Kevin Brown | Kevin Brown | Eric King | Jeff Russell | 18 | 17 | 1 |
| 1991-04-18 | vs TEX | 9 | L 0-7 | 4-5 | 5 | 6,023 | Greg Swindell | Bobby Witt | Bobby Witt | Greg Swindell | | 18 | 24 | -6 |
| 1991-04-20 | vs BOS | 10 | L 1-2 | 4-6 | 6 | 9,153 | Tom Candiotti | Greg Harris | Greg Harris | Tom Candiotti | Jeff Reardon | 19 | 26 | -7 |
| 1991-04-22 | vs KCA | 11 | W 10-4 | 5-6 | 5 | 4,407 | Charles Nagy | Kevin Appier | Charles Nagy | Kevin Appier | | 29 | 30 | -1 |
| 1991-04-23 | vs KCA | 12 | L 0-6 | 5-7 | 5 | 4,805 | Eric King | Storm Davis | Storm Davis | Eric King | | 29 | 36 | -7 |
| 1991-04-24 | vs KCA | 13 | L 2-4 | 5-8 | 6 | 5,157 | Greg Swindell | Bret Saberhagen | Jeff Montgomery | Doug Jones | | 31 | 40 | -9 |
| 1991-04-26 | @ TEX | 14 | W 5-2 | 6-8 | 5 | 29,510 | Tom Candiotti | Nolan Ryan | Steve Olin | Nolan Ryan | Doug Jones | 36 | 42 | -6 |
| 1991-04-27 | @ TEX | 15 | L 1-4 | 6-9 | 5 | 27,428 | Charles Nagy | Scott Chiamparino | Mike Jeffcoat | Steve Olin | Jeff Russell | 37 | 46 | -9 |
| 1991-04-28 | @ TEX | 16 | W 4-2 | 7-9 | 5 | 21,264 | Eric King | Bobby Witt | Eric King | Bobby Witt | Doug Jones | 41 | 48 | -7 |
| 1991-04-30 | @ CAL | 17 | L 5-6 | 7-10 | 5 | 20,740 | Greg Swindell | Scott Lewis | Bryan Harvey | Doug Jones | | 46 | 54 | -8 |
| 1991-05-01 | @ CAL | 18 | W 5-1 | 8-10 | 5 | 21,049 | Tom Candiotti | Chuck Finley | Tom Candiotti | Chuck Finley | | 51 | 55 | -4 |
| 1991-05-03 | @ OAK | 19 | L 3-4 | 8-11 | 5 | 25,252 | Charles Nagy | Dave Stewart | Joe Klink | Steve Olin | | 54 | 59 | -5 |
| 1991-05-04 | @ OAK | 20 | W 20-6 | 9-11 | 5 | 35,028 | Eric King | Kirk Dressendorfer | Eric King | Kirk Dressendorfer | | 74 | 65 | 9 |
| 1991-05-05 | @ OAK | 21 | W 15-6 | 10-11 | 5 | 44,164 | Greg Swindell | Bob Welch | Greg Swindell | Bob Welch | | 89 | 71 | 18 |
| 1991-05-07 | @ SEA | 22 | L 6-7 | 10-12 | 5 | 9,511 | Tom Candiotti | Randy Johnson | Michael Jackson | Doug Jones | | 95 | 78 | 17 |
| 1991-05-08 | @ SEA | 23 | L 2-6 | 10-13 | 5 | 10,930 | Charles Nagy | Brian Holman | Brian Holman | Charles Nagy | Bill Swift | 97 | 84 | 13 |
| 1991-05-10 | vs CAL | 24 | L 2-12 | 10-14 | 5 | 27,301 | Eric King | Mark Langston | Mark Langston | Eric King | | 99 | 96 | 3 |
| 1991-05-11 | vs CAL | 25 | L 1-2 | 10-15 | 5 | 14,720 | Greg Swindell | Jim Abbott | Jim Abbott | Greg Swindell | Bryan Harvey | 100 | 98 | 2 |
| 1991-05-12 | vs CAL | 26 | W 4-1 | 11-15 | 5 | 12,667 | Tom Candiotti | Scott Lewis | Tom Candiotti | Scott Lewis | | 104 | 99 | 5 |
| 1991-05-13 | vs CAL | 27 | L 5-9 | 11-16 | 5 | 5,880 | Charles Nagy | Chuck Finley | Chuck Finley | Steve Olin | Jeff Robinson | 109 | 108 | 1 |
| 1991-05-14 | vs SEA | 28 | L 1-2 | 11-17 | 6 | 5,962 | Rod Nichols | Brian Holman | Brian Holman | Rod Nichols | Bill Swift | 110 | 110 | 0 |
| 1991-05-15 | vs SEA | 29 | L 4-6 | 11-18 | 6 | 6,327 | Eric King | Rich DeLucia | Rich DeLucia | Eric King | Bill Swift | 114 | 116 | -2 |
| 1991-05-16 | vs SEA | 30 | L 1-3 | 11-19 | 6 | 5,665 | Greg Swindell | Bill Krueger | Michael Jackson | Greg Swindell | | 115 | 119 | -4 |
| 1991-05-17 | vs OAK | 31 | W 11-6 | 12-19 | 5 | 43,717 | Tom Candiotti | Mike Moore | Tom Candiotti | Mike Moore | | 126 | 125 | 1 |
| 1991-05-18 | vs OAK | 32 | L 0-3 | 12-20 | 5 | 20,963 | Charles Nagy | Andy Hawkins | Andy Hawkins | Charles Nagy | Dennis Eckersley | 126 | 128 | -2 |
| 1991-05-19 | vs OAK | 33 | L 4-9 | 12-21 | 6 | 29,465 | Rod Nichols | Joe Slusarski | Curt Young | Rod Nichols | | 130 | 137 | -7 |
| 1991-05-20 | vs NYA | 34 | W 3-1 | 13-21 | 5 | 7,047 | Eric King | Chuck Cary | Eric King | Chuck Cary | Shawn Hillegas | 133 | 138 | -5 |
| 1991-05-21 | vs NYA | 35 | W 5-2 | 14-21 | 5 | 11,683 | Greg Swindell | Dave Eiland | Greg Swindell | Dave Eiland | | 138 | 140 | -2 |
| 1991-05-22 | vs NYA | 36 | L 1-8 | 14-22 | 5 | 10,630 | Tom Candiotti | Tim Leary | Tim Leary | Tom Candiotti | | 139 | 148 | -9 |
| 1991-05-23 | @ MIL | 37 | L 3-7 | 14-23 | 5 | 12,623 | Charles Nagy | Don August | Don August | Charles Nagy | Darren Holmes | 142 | 155 | -13 |
| 1991-05-24 | @ MIL | 38 | L 0-1 | 14-24 | 6 | 16,598 | Rod Nichols | Jaime Navarro | Jaime Navarro | Rod Nichols | | 142 | 156 | -14 |
| 1991-05-25 | @ MIL | 39 | W 5-4 | 15-24 | 6 | 17,664 | Eric King | Chris Bosio | Doug Jones | Julio Machado | | 147 | 160 | -13 |
| 1991-05-26 | @ MIL | 40 | L 6-7 | 15-25 | 6 | 23,214 | Greg Swindell | Bill Wegman | Chuck Crim | Doug Jones | | 153 | 167 | -14 |
| 1991-05-27 | @ BAL | 41 | W 3-2 | 16-25 | 6 | 23,338 | Tom Candiotti | Bob Milacki | Tom Candiotti | Bob Milacki | Shawn Hillegas | 156 | 169 | -13 |
| 1991-05-28 | @ BAL | 42 | L 2-5 | 16-26 | 6 | 19,349 | Charles Nagy | Roy Smith | Roy Smith | Charles Nagy | Gregg Olson | 158 | 174 | -16 |
| 1991-05-29 | @ BAL | 43 | L 1-2 | 16-27 | 6 | 23,328 | Rod Nichols | Jeff Robinson | Jeff Robinson | Mike Walker | Gregg Olson | 159 | 176 | -17 |
| 1991-05-31 | vs DET | 44 | W 11-9 | 17-27 | 6 | 22,658 | Eric King | Kevin Ritz | Sergio Valdez | Kevin Ritz | Shawn Hillegas | 170 | 185 | -15 |
| 1991-06-01 | vs DET | 45 | W 3-1 | 18-27 | 6 | 22,535 | Greg Swindell | Bill Gullickson | Greg Swindell | Bill Gullickson | | 173 | 186 | -13 |
| 1991-06-02 | vs DET | 46 | W 3-2 | 19-27 | 6 | 14,164 | Tom Candiotti | Frank Tanana | Tom Candiotti | Frank Tanana | Doug Jones | 176 | 188 | -12 |
| 1991-06-03 | vs DET | 47 | W 2-0 | 20-27 | 6 | 6,832 | Charles Nagy | Walt Terrell | Charles Nagy | Walt Terrell | Shawn Hillegas | 178 | 188 | -10 |
| 1991-06-04 | vs CHA | 48 | L 1-4 | 20-28 | 6 | 8,219 | Rod Nichols | Jack McDowell | Jack McDowell | Rod Nichols | | 179 | 192 | -13 |
| 1991-06-05 | vs CHA | 49 | W 2-1 | 21-28 | 6 | 6,837 | Eric King | Ramon Garcia | Shawn Hillegas | Ramon Garcia | | 181 | 193 | -12 |
| 1991-06-06 | vs CHA | 50 | L 1-2 | 21-29 | 6 | 8,436 | Greg Swindell | Alex Fernandez | Melido Perez | Doug Jones | Bobby Thigpen | 182 | 195 | -13 |
| 1991-06-07 | @ MIN | 51 | L 0-2 | 21-30 | 6 | 18,200 | Tom Candiotti | Allan Anderson | Allan Anderson | Tom Candiotti | Rick Aguilera | 182 | 197 | -15 |
| 1991-06-08 | @ MIN | 52 | L 1-2 | 21-31 | 6 | 25,313 | Charles Nagy | Scott Erickson | Scott Erickson | Charles Nagy | Rick Aguilera | 183 | 199 | -16 |
| 1991-06-09 | @ MIN | 53 | L 2-9 | 21-32 | 6 | 20,677 | Rod Nichols | Jack Morris | Jack Morris | Rod Nichols | | 185 | 208 | -23 |
| 1991-06-10 | @ MIN | 54 | L 5-8 | 21-33 | 6 | 14,171 | Eric King | Mark Guthrie | Paul Abbott | Eric King | Rick Aguilera | 190 | 216 | -26 |
| 1991-06-11 | vs TOR | 55 | W 2-1 | 22-33 | 6 | 10,753 | Greg Swindell | David Wells | Shawn Hillegas | Jim Acker | | 192 | 217 | -25 |
| 1991-06-12 | vs TOR | 56 | L 0-1 | 22-34 | 6 | 8,089 | Tom Candiotti | Mike Timlin | Mike Timlin | Tom Candiotti | Tom Henke | 192 | 218 | -26 |
| 1991-06-13 | vs TOR | 57 | L 0-1 | 22-35 | 6 | 8,371 | Charles Nagy | Jimmy Key | Jimmy Key | Charles Nagy | | 192 | 219 | -27 |
| 1991-06-14 | vs MIN | 58 | L 0-7 | 22-36 | 6 | 55,158 | Jeff Shaw | Jack Morris | Jack Morris | Jeff Shaw | | 192 | 226 | -34 |
| 1991-06-15 | vs MIN | 59 | L 7-11 | 22-37 | 6 | 20,997 | Jeff Mutis | Mark Guthrie | Paul Abbott | Jeff Mutis | | 199 | 237 | -38 |
| 1991-06-16 | vs MIN | 60 | L 2-4 | 22-38 | 7 | 20,725 | Greg Swindell | Kevin Tapani | Rick Aguilera | Shawn Hillegas | | 201 | 241 | -40 |
| 1991-06-18 | @ CHA | 61 | L 5-6 | 22-39 | 7 | 32,151 | Tom Candiotti | Charlie Hough | Charlie Hough | Tom Candiotti | Bobby Thigpen | 206 | 247 | -41 |
| 1991-06-19 | @ CHA | 62 | W 4-3 | 23-39 | 6 | 34,666 | Charles Nagy | Greg Hibbard | Charles Nagy | Greg Hibbard | Rod Nichols | 210 | 250 | -40 |
| 1991-06-21 | @ TOR | 63 | L 4-8 | 23-40 | 6 | 50,283 | Greg Swindell | David Wells | David Wells | Greg Swindell | Tom Henke | 214 | 258 | -44 |
| 1991-06-22 | @ TOR | 64 | L 0-4 | 23-41 | 7 | 50,285 | Jeff Mutis | Juan Guzman | Juan Guzman | Jeff Mutis | Duane Ward | 214 | 262 | -48 |
| 1991-06-23 | @ TOR | 65 | L 1-3 | 23-42 | 7 | 50,275 | Tom Candiotti | Mike Timlin | Bob Macdonald | Tom Candiotti | Tom Henke | 215 | 265 | -50 |
| 1991-06-24 | @ TOR | 66 | L 3-4 | 23-43 | 7 | 50,263 | Charles Nagy | Jimmy Key | Duane Ward | Charles Nagy | Tom Henke | 218 | 269 | -51 |
| 1991-06-25 | vs BAL | 67 | L 3-5 | 23-44 | 7 | 11,150 | Rod Nichols | Jeff Robinson | Mark Williamson | Doug Jones | Gregg Olson | 221 | 274 | -53 |
| 1991-06-26 | vs BAL | 68 | W 10-4 | 24-44 | 7 | 10,457 | Greg Swindell | Jeff Ballard | Greg Swindell | Jeff Ballard | Jeff Shaw | 231 | 278 | -47 |
| 1991-06-27 | vs BAL | 69 | L 2-7 | 24-45 | 7 | 18,889 | Jeff Mutis | Bob Milacki | Bob Milacki | Jeff Mutis | Gregg Olson | 233 | 285 | -52 |
| 1991-06-28 | @ DET | 70 | L 1-7 | 24-46 | 7 | 16,991 | Denis Boucher | Frank Tanana | Frank Tanana | Denis Boucher | | 234 | 292 | -58 |
| 1991-06-29 | @ DET | 71 | L 4-9 | 24-47 | 7 | 39,091 | Charles Nagy | Rusty Meacham | Rusty Meacham | Charles Nagy | Mike Henneman | 238 | 301 | -63 |
| 1991-06-30 | @ DET | 72 | L 1-4 | 24-48 | 7 | 24,640 | Rod Nichols | Walt Terrell | Walt Terrell | Rod Nichols | Mark Leiter | 239 | 305 | -66 |
| 1991-07-01 | @ NYA | 73 | L 2-6 | 24-49 | 7 | 19,720 | Greg Swindell | Scott Sanderson | Scott Sanderson | Greg Swindell | Lee Guetterman | 241 | 311 | -70 |
| 1991-07-02 | @ NYA | 74 | L 5-8 | 24-50 | 7 | 17,636 | Mike York | Wade Taylor | Wade Taylor | Mike York | Steve Farr | 246 | 319 | -73 |
| 1991-07-03 | @ NYA | 75 | L 2-3 | 24-51 | 7 | 18,120 | Denis Boucher | Scott Kamieniecki | Scott Kamieniecki | Denis Boucher | Steve Farr | 248 | 322 | -74 |
| 1991-07-04 | vs MIL | 76 | W 3-0 | 25-51 | 7 | 25,699 | Charles Nagy | Jim Hunter | Charles Nagy | Jim Hunter | | 251 | 322 | -71 |
| 1991-07-05 | vs MIL | 77 | L 2-4 | 25-52 | 7 | 13,221 | Rod Nichols | Bill Wegman | Bill Wegman | Rod Nichols | Dan Plesac | 253 | 326 | -73 |
| 1991-07-06 | vs MIL | 78 | W 2-0 | 26-52 | 7 | 15,461 | Greg Swindell | Jaime Navarro | Greg Swindell | Jaime Navarro | Shawn Hillegas | 255 | 326 | -71 |
| 1991-07-07 | vs MIL | 79 | L 6-10 | 26-53 | 7 | 14,989 | Mike York | Mark Knudson | Chuck Crim | Jeff Shaw | Dan Plesac | 261 | 336 | -75 |
| 1991-07-11 | @ SEA | 80 | L 0-6 | 26-54 | 7 | 12,342 | Charles Nagy | Brian Holman | Brian Holman | Charles Nagy | Bill Swift | 261 | 342 | -81 |
| 1991-07-12 | @ SEA | 81 | L 0-7 | 26-55 | 7 | 15,211 | Rod Nichols | Randy Johnson | Randy Johnson | Rod Nichols | | 261 | 349 | -88 |
| 1991-07-13 | @ SEA | 82 | W 6-3 | 27-55 | 7 | 20,726 | Greg Swindell | Erik Hanson | Greg Swindell | Michael Jackson | | 267 | 352 | -85 |
| 1991-07-14 | @ SEA | 83 | L 3-14 | 27-56 | 7 | 15,441 | Mike York | Rich DeLucia | Rich DeLucia | Mike York | | 270 | 366 | -96 |
| 1991-07-15 | @ OAK | 84 | L 1-6 | 27-57 | 7 | 23,467 | Denis Boucher | Andy Hawkins | Andy Hawkins | Denis Boucher | | 271 | 372 | -101 |
| 1991-07-16 | @ OAK | 85 | L 6-7 | 27-58 | 7 | 24,782 | Charles Nagy | Dave Stewart | Joe Klink | Doug Jones | | 277 | 379 | -102 |
| 1991-07-17 | @ OAK | 86 | W 2-1 | 28-58 | 7 | 40,158 | Rod Nichols | Bob Welch | Rod Nichols | Bob Welch | | 279 | 380 | -101 |
| 1991-07-18 | @ CAL | 87 | L 4-5 | 28-59 | 7 | 24,560 | Greg Swindell | Jim Abbott | Bryan Harvey | Shawn Hillegas | | 283 | 385 | -102 |
| 1991-07-19 | @ CAL | 88 | W 4-2 | 29-59 | 7 | 30,283 | Dave Otto | Chuck Finley | Jesse Orosco | Mark Eichhorn | Steve Olin | 287 | 387 | -100 |
| 1991-07-20 | @ CAL | 89 | W 4-1 | 30-59 | 7 | 27,369 | Denis Boucher | Kirk McCaskill | Denis Boucher | Kirk McCaskill | Steve Olin | 291 | 388 | -97 |
| 1991-07-21 | @ CAL | 90 | W 5-2 | 31-59 | 7 | 34,044 | Charles Nagy | Mark Langston | Charles Nagy | Mark Langston | Steve Olin | 296 | 390 | -94 |
| 1991-07-23 | vs OAK | 91 | L 7-10 | 31-60 | 7 | 26,191 | Rod Nichols | Bob Welch | Rick Honeycutt | Jeff Shaw | | 303 | 400 | -97 |
| 1991-07-24 | vs OAK | 92 | L 4-8 | 31-61 | 7 | 14,553 | Greg Swindell | Eric Show | Eric Show | Greg Swindell | | 307 | 408 | -101 |
| 1991-07-25 | vs OAK | 93 | W 8-7 | 32-61 | 7 | 15,321 | Dave Otto | Andy Hawkins | Mike York | Dennis Eckersley | Steve Olin | 315 | 415 | -100 |
| 1991-07-26 | vs SEA | 94 | L 4-7 | 32-62 | 7 | 12,839 | Denis Boucher | Rich DeLucia | Rich DeLucia | Denis Boucher | Mike Schooler | 319 | 422 | -103 |
| 1991-07-27 | vs SEA | 95 | W 6-1 | 33-62 | 7 | 32,979 | Charles Nagy | Brian Holman | Charles Nagy | Brian Holman | | 325 | 423 | -98 |
| 1991-07-28 | vs SEA | 96 | L 5-6 | 33-63 | 7 | 17,484 | Rod Nichols | Randy Johnson | Randy Johnson | Mike York | Bill Swift | 330 | 429 | -99 |
| 1991-07-29 | vs CAL | 97 | L 2-10 | 33-64 | 7 | 7,998 | Greg Swindell | Chuck Finley | Chuck Finley | Greg Swindell | | 332 | 439 | -107 |
| 1991-07-30 | vs CAL | 98 | L 2-4 | 33-65 | 7 | 11,992 | Dave Otto | Kirk McCaskill | Kirk McCaskill | Dave Otto | Bryan Harvey | 334 | 443 | -109 |
| 1991-07-31 | @ TOR | 99 | L 1-3 | 33-66 | 7 | 50,276 | Eric King | Jimmy Key | Jimmy Key | Eric King | Tom Henke | 335 | 446 | -111 |
| 1991-08-01 | @ TOR | 100 | L 5-7 | 33-67 | 7 | 50,275 | Charles Nagy | Juan Guzman | Duane Ward | Jeff Shaw | Tom Henke | 340 | 453 | -113 |
| 1991-08-02 | vs KCA | 101 | L 4-6 | 33-68 | 7 | 21,712 | Rod Nichols | Kevin Appier | Kevin Appier | Rod Nichols | Jeff Montgomery | 344 | 459 | -115 |
| 1991-08-03 | vs KCA | 102 | W 3-1 | 34-68 | 7 | 13,165 | Greg Swindell | Mark Gubicza | Greg Swindell | Tom Gordon | | 347 | 460 | -113 |
| 1991-08-04 | vs KCA | 103 | L 0-2 | 34-69 | 7 | 13,304 | Dave Otto | Bret Saberhagen | Bret Saberhagen | Dave Otto | | 347 | 462 | -115 |
| 1991-08-05 | @ TEX | 104 | W 9-0 | 35-69 | 7 | 22,315 | Eric King | Kevin Brown | Eric King | Kevin Brown | | 356 | 462 | -106 |
| 1991-08-06 | @ TEX | 105 | L 8-10 | 35-70 | 7 | 23,266 | Charles Nagy | Bobby Witt | Kenny Rogers | Mike York | Jeff Russell | 364 | 472 | -108 |
| 1991-08-07 | @ TEX | 106 | L 10-12 | 35-71 | 7 | 23,943 | Mauro Gozzo | Brian Bohanon | Mike Jeffcoat | Shawn Hillegas | Jeff Russell | 374 | 484 | -110 |
| 1991-08-09 | @ KCA | 107 | L 2-4 | 35-72 | 7 | 40,661 | Greg Swindell | Mark Gubicza | Mark Gubicza | Greg Swindell | Jeff Montgomery | 376 | 488 | -112 |
| 1991-08-10 | @ KCA | 108 | W 1-0 | 36-72 | 7 | 38,209 | Dave Otto | Bret Saberhagen | Dave Otto | Bret Saberhagen | Steve Olin | 377 | 488 | -111 |
| 1991-08-11 | @ KCA | 109 | L 2-3 | 36-73 | 7 | 27,006 | Eric King | Luis Aquino | Tom Gordon | Steve Olin | | 379 | 491 | -112 |
| 1991-08-13 | vs BOS | 110 | W 8-6 | 37-74 | 7 | 0 | Charles Nagy | Matt Young | Shawn Hillegas | Dana Kiecker | Steve Olin | 387 | 497 | -110 |
| 1991-08-13 | vs BOS | 111 | L 5-7 | 37-74 | 7 | 15,506 | Mauro Gozzo | Kevin Morton | Tony Fossas | Rod Nichols | Jeff Reardon | 392 | 504 | -112 |
| 1991-08-14 | vs BOS | 112 | L 1-2 | 37-75 | 7 | 10,636 | Greg Swindell | Joe Hesketh | Joe Hesketh | Greg Swindell | Jeff Reardon | 393 | 506 | -113 |
| 1991-08-15 | vs BOS | 113 | L 2-6 | 37-76 | 7 | 9,160 | Dave Otto | Mike Gardiner | Mike Gardiner | Dave Otto | | 395 | 512 | -117 |
| 1991-08-16 | vs TEX | 114 | L 3-5 | 38-77 | 7 | 0 | Eric King | Kevin Brown | Kevin Brown | Eric King | Jeff Russell | 398 | 517 | -119 |
| 1991-08-16 | vs TEX | 115 | W 13-9 | 38-77 | 7 | 14,540 | Mike York | Bobby Witt | Jesse Orosco | Mike Jeffcoat | | 411 | 526 | -115 |
| 1991-08-17 | vs TEX | 116 | L 0-2 | 38-78 | 7 | 10,511 | Willie Blair | Jose Guzman | Jose Guzman | Willie Blair | Jeff Russell | 411 | 528 | -117 |
| 1991-08-18 | vs TEX | 117 | L 4-9 | 38-79 | 7 | 13,443 | Charles Nagy | Brian Bohanon | Brian Bohanon | Charles Nagy | Wayne Rosenthal | 415 | 537 | -122 |
| 1991-08-21 | @ BOS | 118 | L 5-13 | 38-81 | 7 | 33,000 | Greg Swindell | Joe Hesketh | Joe Hesketh | Greg Swindell | | 420 | 550 | -130 |
| 1991-08-21 | @ BOS | 119 | L 4-5 | 38-81 | 7 | 34,069 | Dave Otto | Roger Clemens | Greg Harris | Steve Olin | | 424 | 555 | -131 |
| 1991-08-22 | @ BOS | 120 | L 6-7 | 38-82 | 7 | 14,037 | Eric King | Mike Gardiner | Greg Harris | Steve Olin | | 430 | 562 | -132 |
| 1991-08-23 | vs CHA | 121 | W 4-3 | 39-82 | 7 | 19,259 | Willie Blair | Greg Hibbard | Willie Blair | Greg Hibbard | Shawn Hillegas | 434 | 565 | -131 |
| 1991-08-24 | vs CHA | 122 | W 2-1 | 40-82 | 7 | 13,915 | Charles Nagy | Jack McDowell | Charles Nagy | Jack McDowell | Steve Olin | 436 | 566 | -130 |
| 1991-08-25 | vs CHA | 123 | W 3-0 | 41-82 | 7 | 10,106 | Rod Nichols | Alex Fernandez | Rod Nichols | Alex Fernandez | | 439 | 566 | -127 |
| 1991-08-26 | vs MIN | 124 | L 3-5 | 41-83 | 7 | 5,003 | Dave Otto | Kevin Tapani | Kevin Tapani | Dave Otto | Rick Aguilera | 442 | 571 | -129 |
| 1991-08-27 | vs MIN | 125 | W 2-1 | 42-83 | 7 | 7,664 | Greg Swindell | Jack Morris | Greg Swindell | Jack Morris | Steve Olin | 444 | 572 | -128 |
| 1991-08-28 | vs MIN | 126 | L 2-4 | 42-84 | 7 | 5,317 | Eric King | David West | David West | Eric King | Rick Aguilera | 446 | 576 | -130 |
| 1991-08-29 | @ CHA | 127 | L 2-7 | 42-85 | 7 | 33,074 | Willie Blair | Jack McDowell | Jack McDowell | Willie Blair | | 448 | 583 | -135 |
| 1991-08-30 | @ CHA | 128 | W 3-2 | 43-85 | 7 | 33,434 | Charles Nagy | Alex Fernandez | Charles Nagy | Alex Fernandez | Steve Olin | 451 | 585 | -134 |
| 1991-08-31 | @ CHA | 129 | L 5-10 | 43-86 | 7 | 41,619 | Dave Otto | Charlie Hough | Donn Pall | Dave Otto | Scott Radinsky | 456 | 595 | -139 |
| 1991-09-01 | @ CHA | 130 | L 1-6 | 43-87 | 7 | 40,179 | Greg Swindell | Wilson Alvarez | Wilson Alvarez | Greg Swindell | | 457 | 601 | -144 |
| 1991-09-02 | @ MIN | 131 | L 3-9 | 43-88 | 7 | 28,267 | Eric King | Scott Erickson | Scott Erickson | Eric King | Rick Aguilera | 460 | 610 | -150 |
| 1991-09-04 | @ MIN | 132 | W 8-4 | 44-88 | 7 | 19,760 | Willie Blair | David West | Willie Blair | David West | Shawn Hillegas | 468 | 614 | -146 |
| 1991-09-05 | vs TOR | 133 | L 1-13 | 44-89 | 7 | 5,666 | Charles Nagy | Jimmy Key | Jimmy Key | Charles Nagy | | 469 | 627 | -158 |
| 1991-09-06 | vs TOR | 134 | L 4-7 | 44-90 | 7 | 14,533 | Dave Otto | Juan Guzman | Juan Guzman | Dave Otto | Duane Ward | 473 | 634 | -161 |
| 1991-09-07 | vs TOR | 135 | L 1-4 | 44-91 | 7 | 17,830 | Greg Swindell | Tom Candiotti | Tom Candiotti | Greg Swindell | | 474 | 638 | -164 |
| 1991-09-08 | vs TOR | 136 | L 5-11 | 44-92 | 7 | 13,071 | Eric King | David Wells | David Wells | Eric King | | 479 | 649 | -170 |
| 1991-09-09 | vs BOS | 137 | L 3-4 | 44-93 | 7 | 1,695 | Willie Blair | Joe Hesketh | Greg Harris | Shawn Hillegas | Jeff Reardon | 482 | 653 | -171 |
| 1991-09-10 | @ MIL | 138 | W 5-2 | 45-93 | 7 | 7,950 | Doug Jones | Bill Wegman | Doug Jones | Bill Wegman | Steve Olin | 487 | 655 | -168 |
| 1991-09-12 | @ BAL | 139 | W 6-5 | 46-93 | 7 | 20,401 | Charles Nagy | Jose Mesa | Charles Nagy | Jose Mesa | Steve Olin | 493 | 660 | -167 |
| 1991-09-13 | @ BAL | 140 | L 4-5 | 46-94 | 7 | 30,861 | Dave Otto | Anthony Telford | Gregg Olson | Jeff Shaw | | 497 | 665 | -168 |
| 1991-09-14 | @ BAL | 141 | W 6-5 | 47-94 | 7 | 31,575 | Greg Swindell | Bob Milacki | Eric Bell | Mike Flanagan | Steve Olin | 503 | 670 | -167 |
| 1991-09-15 | @ BAL | 142 | L 3-4 | 47-95 | 7 | 35,326 | Eric King | Arthur Rhodes | Mark Williamson | Willie Blair | Gregg Olson | 506 | 674 | -168 |
| 1991-09-17 | vs DET | 143 | W 3-1 | 48-95 | 7 | 5,749 | Doug Jones | Walt Terrell | Doug Jones | Walt Terrell | Steve Olin | 509 | 675 | -166 |
| 1991-09-18 | vs DET | 144 | W 3-2 | 49-95 | 7 | 4,976 | Charles Nagy | Bill Gullickson | Charles Nagy | Bill Gullickson | | 512 | 677 | -165 |
| 1991-09-20 | vs BAL | 145 | L 1-2 | 49-96 | 7 | 5,057 | Dave Otto | Bob Milacki | Bob Milacki | Dave Otto | Gregg Olson | 513 | 679 | -166 |
| 1991-09-21 | vs BAL | 146 | W 10-1 | 50-96 | 7 | 6,957 | Greg Swindell | Arthur Rhodes | Greg Swindell | Arthur Rhodes | | 523 | 680 | -157 |
| 1991-09-22 | vs BAL | 147 | W 2-1 | 51-96 | 7 | 6,863 | Shawn Hillegas | Mike Mussina | Eric Bell | Mike Mussina | | 525 | 681 | -156 |
| 1991-09-23 | @ DET | 148 | L 1-2 | 51-97 | 7 | 9,453 | Eric King | Bill Gullickson | Bill Gullickson | Eric King | Mike Henneman | 526 | 683 | -157 |
| 1991-09-24 | @ DET | 149 | L 2-7 | 51-98 | 7 | 10,074 | Charles Nagy | Scott Aldred | Scott Aldred | Charles Nagy | | 528 | 690 | -162 |
| 1991-09-25 | @ DET | 150 | W 6-4 | 52-98 | 7 | 9,563 | Doug Jones | Mark Leiter | Doug Jones | Mark Leiter | Steve Olin | 534 | 694 | -160 |
| 1991-09-26 | @ DET | 151 | L 5-6 | 52-99 | 7 | 9,914 | Dave Otto | Frank Tanana | John Cerutti | Dave Otto | Mike Henneman | 539 | 700 | -161 |
| 1991-09-27 | vs NYA | 152 | L 0-3 | 52-100 | 7 | 6,163 | Greg Swindell | Pascual Perez | Pascual Perez | Greg Swindell | Steve Farr | 539 | 703 | -164 |
| 1991-09-28 | vs NYA | 153 | W 5-4 | 53-100 | 7 | 8,555 | Shawn Hillegas | Jeff Johnson | Eric Bell | Greg Cadaret | Steve Olin | 544 | 707 | -163 |
| 1991-09-29 | vs NYA | 154 | W 5-2 | 54-100 | 7 | 13,006 | Eric King | Alan Mills | Eric King | Alan Mills | Steve Olin | 549 | 709 | -160 |
| 1991-09-30 | vs NYA | 155 | L 0-3 | 54-101 | 7 | 4,145 | Charles Nagy | Scott Sanderson | Scott Sanderson | Charles Nagy | Greg Cadaret | 549 | 712 | -163 |
| 1991-10-01 | vs MIL | 156 | L 0-11 | 55-102 | 7 | 0 | Rod Nichols | Bill Wegman | Bill Wegman | Rod Nichols | | 549 | 723 | -174 |
| 1991-10-01 | vs MIL | 157 | W 6-2 | 55-102 | 7 | 4,346 | Dave Otto | Chris George | Dave Otto | Darren Holmes | | 555 | 725 | -170 |
| 1991-10-02 | vs MIL | 158 | L 4-11 | 55-103 | 7 | 3,785 | Doug Jones | Chris Bosio | Chuck Crim | Doug Jones | Darren Holmes | 559 | 736 | -177 |
| 1991-10-03 | vs MIL | 159 | L 3-9 | 55-104 | 7 | 5,050 | Greg Swindell | Jaime Navarro | Jaime Navarro | Greg Swindell | | 562 | 745 | -183 |
| 1991-10-04 | @ NYA | 160 | W 3-2 | 56-104 | 7 | 14,627 | Shawn Hillegas | Alan Mills | Eric Bell | Steve Farr | Steve Olin | 565 | 747 | -182 |
| 1991-10-05 | @ NYA | 161 | W 7-5 | 57-104 | 7 | 15,681 | Eric King | Eric Plunk | Steve Olin | Darrin Chapin | Doug Jones | 572 | 752 | -180 |
| 1991-10-06 | @ NYA | 162 | L 4-7 | 57-105 | 7 | 17,863 | Charles Nagy | Dave Eiland | Dave Eiland | Charles Nagy | John Habyan | 576 | 759 | -183 |