| 1991-04-09 | vs SLN | 1 | L 1-4 | 0-1 | 5 | 31,622 | Danny Jackson | Bryn Smith | Bryn Smith | Danny Jackson | Lee Smith | 1 | 4 | -3 |
| 1991-04-10 | vs SLN | 2 | W 2-0 | 1-1 | 3 | 11,204 | Greg Maddux | Jose DeLeon | Greg Maddux | Jose DeLeon | Dave Smith | 3 | 4 | -1 |
| 1991-04-11 | vs SLN | 3 | L 4-5 | 1-2 | 4 | 10,830 | Mike Harkey | Ken Hill | Ken Hill | Mike Harkey | Lee Smith | 7 | 9 | -2 |
| 1991-04-12 | vs PIT | 4 | L 1-3 | 1-3 | 6 | 8,704 | Shawn Boskie | John Smiley | John Smiley | Shawn Boskie | Vicente Palacios | 8 | 12 | -4 |
| 1991-04-13 | vs PIT | 5 | W 7-3 | 2-3 | 4 | 23,838 | Mike Bielecki | Doug Drabek | Mike Bielecki | Doug Drabek | | 15 | 15 | 0 |
| 1991-04-14 | vs PIT | 6 | W 6-4 | 3-3 | 2 | 25,994 | Danny Jackson | Bob Walk | Heathcliff Slocumb | Stan Belinda | Dave Smith | 21 | 19 | 2 |
| 1991-04-15 | vs PHI | 7 | W 5-4 | 4-3 | 2 | 27,794 | Greg Maddux | Jason Grimsley | Greg Maddux | Jason Grimsley | Dave Smith | 26 | 23 | 3 |
| 1991-04-16 | vs PHI | 8 | W 4-3 | 5-3 | 2 | 11,571 | Mike Harkey | Jose De Jesus | Mike Bielecki | Mitch Williams | | 30 | 26 | 4 |
| 1991-04-17 | vs PHI | 9 | W 4-1 | 6-3 | 1 | 13,680 | Shawn Boskie | Pat Combs | Shawn Boskie | Pat Combs | Dave Smith | 34 | 27 | 7 |
| 1991-04-18 | @ PIT | 10 | W 3-2 | 7-3 | 1 | 9,148 | Rick Sutcliffe | Doug Drabek | Rick Sutcliffe | Doug Drabek | Paul Assenmacher | 37 | 29 | 8 |
| 1991-04-19 | @ PIT | 11 | L 4-5 | 7-4 | 1 | 13,157 | Danny Jackson | Vicente Palacios | Stan Belinda | Dave Smith | | 41 | 34 | 7 |
| 1991-04-20 | @ PIT | 12 | L 3-9 | 7-5 | 1 | 13,179 | Greg Maddux | Zane Smith | Zane Smith | Greg Maddux | | 44 | 43 | 1 |
| 1991-04-21 | @ PIT | 13 | L 12-13 | 7-6 | 3 | 10,860 | Mike Harkey | Randy Tomlin | Bob Patterson | Mike Bielecki | | 56 | 56 | 0 |
| 1991-04-22 | @ SLN | 14 | L 2-3 | 7-7 | 4 | 23,943 | Shawn Boskie | Jamie Moyer | Juan Agosto | Dave Smith | | 58 | 59 | -1 |
| 1991-04-23 | @ SLN | 15 | L 2-4 | 7-8 | 4 | 25,384 | Rick Sutcliffe | Bob Tewksbury | Bob Tewksbury | Rick Sutcliffe | Lee Smith | 60 | 63 | -3 |
| 1991-04-24 | @ SLN | 16 | W 1-0 | 8-8 | 4 | 25,339 | Mike Bielecki | Jose DeLeon | Mike Bielecki | Jose DeLeon | Paul Assenmacher | 61 | 63 | -2 |
| 1991-04-25 | @ CIN | 17 | L 4-6 | 8-9 | 4 | 22,914 | Greg Maddux | Tom Browning | Ted Power | Heathcliff Slocumb | Randy Myers | 65 | 69 | -4 |
| 1991-04-26 | @ CIN | 18 | L 1-3 | 8-10 | 4 | 37,681 | Mike Harkey | Jose Rijo | Jose Rijo | Mike Harkey | Rob Dibble | 66 | 72 | -6 |
| 1991-04-27 | @ CIN | 19 | W 8-3 | 9-10 | 4 | 35,265 | Shawn Boskie | Norm Charlton | Shawn Boskie | Norm Charlton | Paul Assenmacher | 74 | 75 | -1 |
| 1991-04-28 | @ CIN | 20 | L 3-4 | 9-11 | 4 | 33,518 | Rick Sutcliffe | Chris Hammond | Chris Hammond | Rick Sutcliffe | Rob Dibble | 77 | 79 | -2 |
| 1991-04-30 | vs HOU | 21 | W 10-3 | 10-11 | 4 | 27,523 | Mike Bielecki | Mark Portugal | Mike Bielecki | Mark Portugal | | 87 | 82 | 5 |
| 1991-05-01 | vs HOU | 22 | W 11-8 | 11-11 | 4 | 17,606 | Greg Maddux | Jim Deshaies | Greg Maddux | Jim Deshaies | | 98 | 90 | 8 |
| 1991-05-03 | @ ATL | 23 | L 2-5 | 11-12 | 4 | 30,476 | Shawn Boskie | Tom Glavine | Tom Glavine | Shawn Boskie | Kent Mercker | 100 | 95 | 5 |
| 1991-05-04 | @ ATL | 24 | L 2-4 | 11-13 | 4 | 20,724 | Rick Sutcliffe | John Smoltz | John Smoltz | Rick Sutcliffe | Juan Berenguer | 102 | 99 | 3 |
| 1991-05-05 | @ ATL | 25 | W 9-6 | 12-13 | 4 | 27,141 | Mike Bielecki | Charlie Leibrandt | Chuck McElroy | Charlie Leibrandt | Dave Smith | 111 | 105 | 6 |
| 1991-05-06 | @ HOU | 26 | W 4-3 | 13-13 | 4 | 9,736 | Greg Maddux | Jim Deshaies | Greg Maddux | Jim Deshaies | Dave Smith | 115 | 108 | 7 |
| 1991-05-07 | @ HOU | 27 | W 4-3 | 14-13 | 4 | 13,640 | Bob Scanlan | Xavier Hernandez | Bob Scanlan | Xavier Hernandez | Dave Smith | 119 | 111 | 8 |
| 1991-05-08 | @ HOU | 28 | L 2-4 | 14-14 | 4 | 11,307 | Shawn Boskie | Pete Harnisch | Pete Harnisch | Shawn Boskie | Curt Schilling | 121 | 115 | 6 |
| 1991-05-10 | vs CIN | 29 | W 6-5 | 15-14 | 4 | 35,484 | Rick Sutcliffe | Tom Browning | Rick Sutcliffe | Tom Browning | Dave Smith | 127 | 120 | 7 |
| 1991-05-11 | vs CIN | 30 | L 2-12 | 15-15 | 4 | 35,998 | Mike Bielecki | Jose Rijo | Jose Rijo | Mike Bielecki | | 129 | 132 | -3 |
| 1991-05-12 | vs CIN | 31 | L 3-5 | 15-16 | 5 | 32,353 | Greg Maddux | Jack Armstrong | Jack Armstrong | Greg Maddux | Rob Dibble | 132 | 137 | -5 |
| 1991-05-13 | vs ATL | 32 | L 3-5 | 15-17 | 5 | 29,579 | Shawn Boskie | Tom Glavine | Tom Glavine | Shawn Boskie | | 135 | 142 | -7 |
| 1991-05-14 | vs ATL | 33 | W 5-4 | 16-17 | 4 | 31,446 | Bob Scanlan | John Smoltz | Paul Assenmacher | Kent Mercker | Dave Smith | 140 | 146 | -6 |
| 1991-05-15 | vs ATL | 34 | W 6-1 | 17-17 | 4 | 25,814 | Rick Sutcliffe | Charlie Leibrandt | Paul Assenmacher | Juan Berenguer | | 146 | 147 | -1 |
| 1991-05-17 | @ PHI | 35 | L 0-1 | 17-18 | 4 | 28,044 | Greg Maddux | Pat Combs | Tommy Greene | Les Lancaster | | 146 | 148 | -2 |
| 1991-05-18 | @ PHI | 36 | L 2-5 | 17-19 | 5 | 34,877 | Shawn Boskie | Danny Cox | Joe Boever | Paul Assenmacher | Mitch Williams | 148 | 153 | -5 |
| 1991-05-19 | @ PHI | 37 | W 2-1 | 18-19 | 4 | 27,830 | Bob Scanlan | Terry Mulholland | Mike Bielecki | Roger McDowell | Dave Smith | 150 | 154 | -4 |
| 1991-05-21 | @ NYN | 38 | L 6-8 | 18-20 | 5 | 29,129 | Rick Sutcliffe | Dwight Gooden | Dwight Gooden | Rick Sutcliffe | John Franco | 156 | 162 | -6 |
| 1991-05-22 | @ NYN | 39 | W 5-2 | 19-20 | 4 | 28,749 | Greg Maddux | Frank Viola | Greg Maddux | Frank Viola | | 161 | 164 | -3 |
| 1991-05-23 | @ NYN | 40 | W 4-3 | 20-20 | 4 | 29,763 | Shawn Boskie | Ron Darling | Les Lancaster | John Franco | Paul Assenmacher | 165 | 167 | -2 |
| 1991-05-24 | vs MON | 41 | W 4-3 | 21-20 | 4 | 32,410 | Bob Scanlan | Mark Gardner | Bob Scanlan | Mark Gardner | Heathcliff Slocumb | 169 | 170 | -1 |
| 1991-05-25 | vs MON | 42 | W 6-1 | 22-20 | 4 | 16,961 | Mike Bielecki | Rick Mahler | Mike Bielecki | Rick Mahler | Chuck McElroy | 175 | 171 | 4 |
| 1991-05-26 | vs MON | 43 | W 8-6 | 23-20 | 4 | 35,417 | Rick Sutcliffe | Dennis Martinez | Les Lancaster | Tim Burke | Dave Smith | 183 | 177 | 6 |
| 1991-05-27 | vs NYN | 44 | L 1-3 | 23-21 | 4 | 33,897 | Greg Maddux | Frank Viola | Frank Viola | Greg Maddux | John Franco | 184 | 180 | 4 |
| 1991-05-28 | vs NYN | 45 | L 8-9 | 23-22 | 4 | 32,811 | Shawn Boskie | Ron Darling | Alejandro Pena | Paul Assenmacher | John Franco | 192 | 189 | 3 |
| 1991-05-29 | vs NYN | 46 | L 1-8 | 23-23 | 4 | 31,359 | Bob Scanlan | David Cone | David Cone | Bob Scanlan | | 193 | 197 | -4 |
| 1991-05-31 | @ MON | 47 | W 7-2 | 24-23 | 4 | 17,308 | Mike Bielecki | Dennis Martinez | Mike Bielecki | Dennis Martinez | Les Lancaster | 200 | 199 | 1 |
| 1991-06-01 | @ MON | 48 | W 2-1 | 25-23 | 4 | 22,184 | Greg Maddux | Chris Nabholz | Chuck McElroy | Barry Jones | Dave Smith | 202 | 200 | 2 |
| 1991-06-02 | @ MON | 49 | W 4-3 | 26-23 | 4 | 23,070 | Shawn Boskie | Brian Barnes | Paul Assenmacher | Scott Ruskin | Dave Smith | 206 | 203 | 3 |
| 1991-06-04 | vs SDN | 50 | L 1-7 | 26-24 | 4 | 32,712 | Bob Scanlan | Andy Benes | Andy Benes | Bob Scanlan | | 207 | 210 | -3 |
| 1991-06-05 | vs SDN | 51 | L 0-3 | 26-25 | 4 | 22,500 | Mike Bielecki | Dennis Rasmussen | Dennis Rasmussen | Mike Bielecki | | 207 | 213 | -6 |
| 1991-06-06 | vs SDN | 52 | W 6-2 | 27-25 | 4 | 23,200 | Greg Maddux | Jose Melendez | Greg Maddux | Jose Melendez | | 213 | 215 | -2 |
| 1991-06-07 | vs LAN | 53 | L 2-3 | 27-26 | 4 | 35,414 | Shawn Boskie | Mike Morgan | Mike Morgan | Shawn Boskie | Jay Howell | 215 | 218 | -3 |
| 1991-06-08 | vs LAN | 54 | W 4-3 | 28-26 | 4 | 35,101 | Bob Scanlan | Tim Belcher | Chuck McElroy | Kevin Gross | Dave Smith | 219 | 221 | -2 |
| 1991-06-09 | vs LAN | 55 | L 3-6 | 28-27 | 4 | 34,446 | Danny Jackson | Orel Hershiser | Orel Hershiser | Danny Jackson | | 222 | 227 | -5 |
| 1991-06-10 | vs LAN | 56 | L 5-13 | 28-28 | 4 | 33,204 | Mike Bielecki | Ramon Martinez | Ramon Martinez | Mike Bielecki | Mike Hartley | 227 | 240 | -13 |
| 1991-06-11 | vs SFN | 57 | L 6-8 | 28-29 | 4 | 32,449 | Greg Maddux | Buddy Black | Kelly Downs | Dave Smith | Dave Righetti | 233 | 248 | -15 |
| 1991-06-12 | vs SFN | 58 | W 6-1 | 29-29 | 4 | 33,880 | Shawn Boskie | Don Robinson | Shawn Boskie | Don Robinson | Dave Smith | 239 | 249 | -10 |
| 1991-06-13 | vs SFN | 59 | W 4-3 | 30-29 | 4 | 34,149 | Bob Scanlan | Trevor Wilson | Mike Bielecki | Trevor Wilson | Paul Assenmacher | 243 | 252 | -9 |
| 1991-06-14 | @ SDN | 60 | W 7-3 | 31-29 | 4 | 30,161 | Danny Jackson | Andy Benes | Danny Jackson | Andy Benes | Dave Smith | 250 | 255 | -5 |
| 1991-06-15 | @ SDN | 61 | L 2-6 | 31-30 | 4 | 23,557 | Les Lancaster | Dennis Rasmussen | Dennis Rasmussen | Mike Bielecki | | 252 | 261 | -9 |
| 1991-06-16 | @ SDN | 62 | L 2-4 | 31-31 | 4 | 28,961 | Greg Maddux | Jose Melendez | Jose Melendez | Greg Maddux | Larry Andersen | 254 | 265 | -11 |
| 1991-06-17 | @ LAN | 63 | L 4-6 | 31-32 | 4 | 42,767 | Shawn Boskie | Mike Morgan | Mike Morgan | Shawn Boskie | Tim Crews | 258 | 271 | -13 |
| 1991-06-18 | @ LAN | 64 | L 5-6 | 31-33 | 4 | 37,402 | Bob Scanlan | Tim Belcher | Mike Hartley | Mike Bielecki | | 263 | 277 | -14 |
| 1991-06-19 | @ LAN | 65 | L 8-9 | 31-34 | 4 | 39,287 | Danny Jackson | Orel Hershiser | Jay Howell | Paul Assenmacher | | 271 | 286 | -15 |
| 1991-06-20 | @ SFN | 66 | L 3-4 | 31-35 | 5 | 16,408 | Les Lancaster | Mike Remlinger | Francisco Oliveras | Les Lancaster | Dave Righetti | 274 | 290 | -16 |
| 1991-06-21 | @ SFN | 67 | L 2-4 | 31-36 | 5 | 17,198 | Greg Maddux | Buddy Black | Kelly Downs | Greg Maddux | Dave Righetti | 276 | 294 | -18 |
| 1991-06-22 | @ SFN | 68 | L 3-6 | 31-37 | 5 | 31,841 | Shawn Boskie | Trevor Wilson | Trevor Wilson | Shawn Boskie | Francisco Oliveras | 279 | 300 | -21 |
| 1991-06-23 | @ SFN | 69 | L 1-2 | 31-38 | 5 | 42,389 | Bob Scanlan | John Burkett | Jeff Brantley | Dave Smith | | 280 | 302 | -22 |
| 1991-06-25 | @ PIT | 70 | W 5-1 | 32-38 | 5 | 31,115 | Les Lancaster | John Smiley | Les Lancaster | John Smiley | | 285 | 303 | -18 |
| 1991-06-26 | @ PIT | 71 | L 6-7 | 32-39 | 5 | 41,389 | Greg Maddux | Bob Walk | Bob Walk | Greg Maddux | Bill Landrum | 291 | 310 | -19 |
| 1991-06-27 | @ PIT | 72 | L 3-4 | 32-40 | 5 | 30,960 | Frank Castillo | Doug Drabek | Vicente Palacios | Paul Assenmacher | | 294 | 314 | -20 |
| 1991-06-28 | vs SLN | 73 | L 6-14 | 32-41 | 5 | 35,220 | Bob Scanlan | Omar Olivares | Omar Olivares | Bob Scanlan | | 300 | 328 | -28 |
| 1991-06-29 | vs SLN | 74 | W 6-4 | 33-41 | 4 | 34,957 | Les Lancaster | Bob Tewksbury | Les Lancaster | Bob Tewksbury | Paul Assenmacher | 306 | 332 | -26 |
| 1991-06-30 | vs SLN | 75 | W 7-4 | 34-41 | 4 | 32,736 | Greg Maddux | Jose DeLeon | Chuck McElroy | Jose DeLeon | | 313 | 336 | -23 |
| 1991-07-01 | vs PIT | 76 | W 6-5 | 35-41 | 4 | 32,633 | Frank Castillo | Bob Walk | Bob Scanlan | Stan Belinda | | 319 | 341 | -22 |
| 1991-07-02 | vs PIT | 77 | L 4-13 | 35-42 | 4 | 34,332 | Shawn Boskie | Doug Drabek | Doug Drabek | Shawn Boskie | | 323 | 354 | -31 |
| 1991-07-03 | vs PIT | 78 | L 7-11 | 35-43 | 4 | 33,432 | Les Lancaster | Zane Smith | Zane Smith | Les Lancaster | | 330 | 365 | -35 |
| 1991-07-04 | vs PIT | 79 | W 9-8 | 36-43 | 4 | 31,098 | Greg Maddux | Randy Tomlin | Chuck McElroy | Bill Landrum | | 339 | 373 | -34 |
| 1991-07-05 | @ SLN | 80 | W 5-1 | 37-43 | 4 | 49,251 | Frank Castillo | Jose DeLeon | Frank Castillo | Jose DeLeon | | 344 | 374 | -30 |
| 1991-07-06 | @ SLN | 81 | W 12-2 | 38-43 | 4 | 48,313 | Mike Bielecki | Bryn Smith | Mike Bielecki | Bryn Smith | | 356 | 376 | -20 |
| 1991-07-07 | @ SLN | 82 | L 7-8 | 38-44 | 4 | 39,595 | Les Lancaster | Ken Hill | Willie Fraser | Laddie Renfroe | | 363 | 384 | -21 |
| 1991-07-11 | vs HOU | 83 | L 4-6 | 38-45 | 4 | 32,313 | Greg Maddux | Jim Deshaies | Al Osuna | Dave Smith | Mike Capel | 367 | 390 | -23 |
| 1991-07-12 | vs HOU | 84 | W 5-2 | 39-45 | 4 | 33,772 | Frank Castillo | Mark Portugal | Frank Castillo | Mark Portugal | Paul Assenmacher | 372 | 392 | -20 |
| 1991-07-13 | vs HOU | 85 | W 4-3 | 40-45 | 4 | 32,588 | Les Lancaster | Pete Harnisch | Les Lancaster | Mike Capel | | 376 | 395 | -19 |
| 1991-07-14 | vs HOU | 86 | W 4-3 | 41-45 | 4 | 33,750 | Mike Bielecki | Darryl Kile | Mike Bielecki | Darryl Kile | Paul Assenmacher | 380 | 398 | -18 |
| 1991-07-15 | @ ATL | 87 | W 6-4 | 42-45 | 4 | 25,057 | Greg Maddux | Pete Smith | Greg Maddux | Pete Smith | Paul Assenmacher | 386 | 402 | -16 |
| 1991-07-16 | @ ATL | 88 | L 5-8 | 42-46 | 4 | 25,893 | Frank Castillo | Steve Avery | Marvin Freeman | Bob Scanlan | Juan Berenguer | 391 | 410 | -19 |
| 1991-07-17 | @ ATL | 89 | L 2-12 | 42-47 | 4 | 16,984 | Les Lancaster | John Smoltz | John Smoltz | Les Lancaster | | 393 | 422 | -29 |
| 1991-07-19 | @ HOU | 90 | L 2-5 | 42-48 | 4 | 27,577 | Mike Bielecki | Pete Harnisch | Pete Harnisch | Bob Scanlan | Al Osuna | 395 | 427 | -32 |
| 1991-07-20 | @ HOU | 91 | W 6-0 | 43-48 | 4 | 37,970 | Greg Maddux | Darryl Kile | Greg Maddux | Darryl Kile | | 401 | 427 | -26 |
| 1991-07-21 | @ HOU | 92 | W 4-2 | 44-48 | 4 | 28,847 | Frank Castillo | Jimmy Jones | Frank Castillo | Jim Clancy | | 405 | 429 | -24 |
| 1991-07-23 | vs CIN | 93 | W 8-5 | 45-48 | 4 | 34,458 | Les Lancaster | Randy Myers | Les Lancaster | Randy Myers | Paul Assenmacher | 413 | 434 | -21 |
| 1991-07-24 | vs CIN | 94 | L 3-12 | 45-49 | 4 | 36,215 | Mike Bielecki | Tom Browning | Tom Browning | Mike Bielecki | | 416 | 446 | -30 |
| 1991-07-25 | vs CIN | 95 | W 5-4 | 46-49 | 4 | 35,008 | Greg Maddux | Jose Rijo | Heathcliff Slocumb | Tim Layana | | 421 | 450 | -29 |
| 1991-07-26 | vs ATL | 96 | L 2-6 | 46-50 | 4 | 35,604 | Frank Castillo | Steve Avery | Steve Avery | Frank Castillo | | 423 | 456 | -33 |
| 1991-07-27 | vs ATL | 97 | W 7-5 | 47-50 | 4 | 34,023 | Les Lancaster | John Smoltz | Les Lancaster | John Smoltz | Chuck McElroy | 430 | 461 | -31 |
| 1991-07-28 | vs ATL | 98 | W 6-2 | 48-50 | 4 | 33,782 | Mike Bielecki | Charlie Leibrandt | Mike Bielecki | Charlie Leibrandt | Paul Assenmacher | 436 | 463 | -27 |
| 1991-07-30 | @ CIN | 99 | L 5-6 | 48-51 | 4 | 37,832 | Greg Maddux | Tom Browning | Rob Dibble | Chuck McElroy | | 441 | 469 | -28 |
| 1991-07-31 | @ CIN | 100 | L 1-5 | 48-52 | 4 | 36,483 | Frank Castillo | Jose Rijo | Jose Rijo | Frank Castillo | Ted Power | 442 | 474 | -32 |
| 1991-08-02 | @ NYN | 101 | W 4-2 | 49-52 | 4 | 35,361 | Mike Bielecki | Dwight Gooden | Paul Assenmacher | Alejandro Pena | | 446 | 476 | -30 |
| 1991-08-03 | @ NYN | 102 | W 9-2 | 50-52 | 4 | 39,804 | Danny Jackson | Frank Viola | Bob Scanlan | Frank Viola | | 455 | 478 | -23 |
| 1991-08-04 | @ NYN | 103 | W 8-3 | 51-52 | 4 | 36,080 | Greg Maddux | David Cone | Greg Maddux | David Cone | | 463 | 481 | -18 |
| 1991-08-05 | @ NYN | 104 | W 7-2 | 52-52 | 4 | 27,508 | Frank Castillo | Pete Schourek | Frank Castillo | Pete Schourek | | 470 | 483 | -13 |
| 1991-08-06 | @ PHI | 105 | L 2-6 | 52-53 | 4 | 26,562 | Rick Sutcliffe | Bruce Ruffin | Mitch Williams | Les Lancaster | | 472 | 489 | -17 |
| 1991-08-07 | @ PHI | 106 | L 4-5 | 52-54 | 4 | 26,294 | Mike Bielecki | Terry Mulholland | Mitch Williams | Les Lancaster | | 476 | 494 | -18 |
| 1991-08-08 | @ PHI | 107 | L 1-11 | 52-55 | 4 | 32,232 | Danny Jackson | Danny Cox | Danny Cox | Danny Jackson | | 477 | 505 | -28 |
| 1991-08-09 | vs NYN | 108 | W 5-4 | 53-55 | 4 | 36,110 | Greg Maddux | David Cone | Greg Maddux | David Cone | | 482 | 509 | -27 |
| 1991-08-10 | vs NYN | 109 | W 6-2 | 54-55 | 4 | 35,639 | Frank Castillo | Wally Whitehurst | Bob Scanlan | Tim Burke | Les Lancaster | 488 | 511 | -23 |
| 1991-08-11 | vs NYN | 110 | W 3-2 | 55-55 | 4 | 33,128 | Rick Sutcliffe | Sid Fernandez | Shawn Boskie | Pete Schourek | | 491 | 513 | -22 |
| 1991-08-12 | vs NYN | 111 | W 3-2 | 56-55 | 4 | 34,342 | Mike Bielecki | Dwight Gooden | Les Lancaster | Tim Burke | | 494 | 515 | -21 |
| 1991-08-13 | vs MON | 112 | L 6-7 | 56-56 | 4 | 34,085 | Danny Jackson | Mark Gardner | Bill Sampen | Les Lancaster | Jeff Fassero | 500 | 522 | -22 |
| 1991-08-14 | vs MON | 113 | L 0-2 | 56-57 | 4 | 34,817 | Greg Maddux | Brian Barnes | Brian Barnes | Greg Maddux | Barry Jones | 500 | 524 | -24 |
| 1991-08-15 | vs MON | 114 | W 7-6 | 57-57 | 3 | 33,514 | Bob Scanlan | Chris Haney | Paul Assenmacher | Jeff Fassero | Chuck McElroy | 507 | 530 | -23 |
| 1991-08-16 | vs PHI | 115 | W 9-1 | 58-57 | 3 | 34,547 | Rick Sutcliffe | Bruce Ruffin | Rick Sutcliffe | Bruce Ruffin | | 516 | 531 | -15 |
| 1991-08-17 | vs PHI | 116 | L 2-5 | 58-58 | 3 | 33,223 | Mike Bielecki | Terry Mulholland | Terry Mulholland | Mike Bielecki | Mitch Williams | 518 | 536 | -18 |
| 1991-08-18 | vs PHI | 117 | W 7-6 | 59-58 | 3 | 32,801 | Danny Jackson | Danny Cox | Paul Assenmacher | Mitch Williams | | 525 | 542 | -17 |
| 1991-08-19 | @ MON | 118 | W 3-2 | 60-58 | 3 | 10,792 | Greg Maddux | Brian Barnes | Paul Assenmacher | Bill Sampen | | 528 | 544 | -16 |
| 1991-08-20 | @ MON | 119 | L 2-4 | 60-59 | 3 | 12,987 | Bob Scanlan | Chris Haney | Chris Haney | Bob Scanlan | Mel Rojas | 530 | 548 | -18 |
| 1991-08-21 | @ MON | 120 | W 3-1 | 61-59 | 3 | 15,192 | Rick Sutcliffe | Chris Nabholz | Rick Sutcliffe | Chris Nabholz | Les Lancaster | 533 | 549 | -16 |
| 1991-08-23 | vs SDN | 121 | W 5-4 | 62-59 | 3 | 33,090 | Mike Bielecki | Bruce Hurst | Les Lancaster | Craig Lefferts | | 538 | 553 | -15 |
| 1991-08-24 | vs SDN | 122 | L 1-4 | 62-60 | 3 | 32,760 | Greg Maddux | Andy Benes | Andy Benes | Greg Maddux | Jose Melendez | 539 | 557 | -18 |
| 1991-08-25 | vs SDN | 123 | L 9-12 | 62-61 | 3 | 31,190 | Danny Jackson | Dennis Rasmussen | Mike Maddux | Bob Scanlan | Jose Melendez | 548 | 569 | -21 |
| 1991-08-26 | vs LAN | 124 | L 3-4 | 62-62 | 3 | 31,149 | Rick Sutcliffe | Orel Hershiser | Jim Gott | Chuck McElroy | Jay Howell | 551 | 573 | -22 |
| 1991-08-27 | vs LAN | 125 | W 2-1 | 63-62 | 3 | 31,624 | Frank Castillo | Ramon Martinez | Frank Castillo | Ramon Martinez | | 553 | 574 | -21 |
| 1991-08-28 | @ SFN | 126 | W 8-6 | 64-62 | 3 | 16,230 | Mike Bielecki | Paul McClellan | Mike Bielecki | Paul McClellan | Paul Assenmacher | 561 | 580 | -19 |
| 1991-08-29 | @ SFN | 127 | W 5-4 | 65-62 | 3 | 19,887 | Greg Maddux | Trevor Wilson | Greg Maddux | Francisco Oliveras | | 566 | 584 | -18 |
| 1991-08-30 | @ LAN | 128 | L 0-2 | 65-63 | 3 | 39,666 | Danny Jackson | Tim Belcher | Tim Belcher | Danny Jackson | | 566 | 586 | -20 |
| 1991-08-31 | @ LAN | 129 | L 2-3 | 65-64 | 3 | 46,943 | Rick Sutcliffe | Kevin Gross | Roger McDowell | Paul Assenmacher | Jay Howell | 568 | 589 | -21 |
| 1991-09-01 | @ LAN | 130 | L 3-12 | 65-65 | 3 | 38,742 | Frank Castillo | Ramon Martinez | Ramon Martinez | Frank Castillo | | 571 | 601 | -30 |
| 1991-09-02 | @ SDN | 131 | W 10-8 | 66-65 | 3 | 12,706 | Mike Bielecki | Bruce Hurst | Chuck McElroy | Jose Melendez | | 581 | 609 | -28 |
| 1991-09-03 | @ SDN | 132 | L 1-4 | 66-66 | 3 | 9,047 | Greg Maddux | Andy Benes | Andy Benes | Greg Maddux | | 582 | 613 | -31 |
| 1991-09-04 | @ SDN | 133 | L 1-5 | 66-67 | 3 | 9,952 | Danny Jackson | Dennis Rasmussen | Dennis Rasmussen | Danny Jackson | | 583 | 618 | -35 |
| 1991-09-06 | vs SFN | 134 | W 3-2 | 67-67 | 3 | 22,090 | Frank Castillo | Bryan Hickerson | Frank Castillo | Bryan Hickerson | Dave Smith | 586 | 620 | -34 |
| 1991-09-07 | vs SFN | 135 | W 2-1 | 68-67 | 3 | 30,821 | Mike Bielecki | Paul McClellan | Mike Bielecki | Paul McClellan | Paul Assenmacher | 588 | 621 | -33 |
| 1991-09-08 | vs SFN | 136 | L 3-4 | 68-68 | 3 | 27,875 | Greg Maddux | Trevor Wilson | Trevor Wilson | Greg Maddux | Dave Righetti | 591 | 625 | -34 |
| 1991-09-09 | vs PIT | 137 | L 10-12 | 68-69 | 3 | 18,775 | Danny Jackson | John Smiley | Stan Belinda | Dave Smith | Rosario Rodriguez | 601 | 637 | -36 |
| 1991-09-10 | vs PIT | 138 | W 6-2 | 69-69 | 3 | 29,299 | Rick Sutcliffe | Randy Tomlin | Rick Sutcliffe | Randy Tomlin | Bob Scanlan | 607 | 639 | -32 |
| 1991-09-11 | vs NYN | 139 | L 1-4 | 69-70 | 3 | 15,795 | Frank Castillo | Tony Castillo | Tony Castillo | Frank Castillo | John Franco | 608 | 643 | -35 |
| 1991-09-12 | vs NYN | 140 | L 3-6 | 69-71 | 3 | 14,324 | Mike Bielecki | Anthony Young | Anthony Young | Mike Bielecki | Wally Whitehurst | 611 | 649 | -38 |
| 1991-09-13 | vs MON | 141 | L 2-3 | 69-72 | 3 | 17,668 | Greg Maddux | Dennis Martinez | Dennis Martinez | Bob Scanlan | Barry Jones | 613 | 652 | -39 |
| 1991-09-14 | vs MON | 142 | W 7-5 | 70-72 | 3 | 30,130 | Shawn Boskie | Brian Barnes | Bob Scanlan | Barry Jones | | 620 | 657 | -37 |
| 1991-09-15 | vs MON | 143 | L 5-6 | 70-73 | 3 | 25,601 | Rick Sutcliffe | Mark Gardner | Mel Rojas | Paul Assenmacher | Jeff Fassero | 625 | 663 | -38 |
| 1991-09-16 | @ PIT | 144 | L 4-5 | 70-74 | 3 | 16,149 | Frank Castillo | Zane Smith | Zane Smith | Frank Castillo | Roger Mason | 629 | 668 | -39 |
| 1991-09-17 | @ PIT | 145 | L 2-9 | 70-75 | 3 | 18,152 | Mike Bielecki | Doug Drabek | Doug Drabek | Mike Bielecki | | 631 | 677 | -46 |
| 1991-09-18 | @ NYN | 146 | W 4-1 | 71-75 | 3 | 11,980 | Greg Maddux | Frank Viola | Greg Maddux | Frank Viola | | 635 | 678 | -43 |
| 1991-09-22 | vs MON | 147 | L 2-6 | 71-77 | 4 | 0 | Rick Sutcliffe | Mark Gardner | Mark Gardner | Rick Sutcliffe | | 637 | 684 | -47 |
| 1991-09-22 | vs MON | 148 | L 3-5 | 71-77 | 4 | 16,061 | Frank Castillo | Bill Sampen | Bill Sampen | Frank Castillo | Mel Rojas | 640 | 689 | -49 |
| 1991-09-23 | vs PHI | 149 | W 10-3 | 72-77 | 3 | 16,141 | Greg Maddux | Terry Mulholland | Greg Maddux | Terry Mulholland | | 650 | 692 | -42 |
| 1991-09-24 | vs PHI | 150 | L 2-4 | 72-78 | 3 | 19,694 | Mike Bielecki | Andy Ashby | Andy Ashby | Mike Bielecki | Mitch Williams | 652 | 696 | -44 |
| 1991-09-25 | vs PHI | 151 | L 4-5 | 72-79 | 5 | 9,892 | Shawn Boskie | Tommy Greene | Tommy Greene | Shawn Boskie | Mitch Williams | 656 | 701 | -45 |
| 1991-09-27 | @ SLN | 152 | L 4-5 | 72-80 | 5 | 30,429 | Frank Castillo | Bob Tewksbury | Bob Tewksbury | Frank Castillo | Lee Smith | 660 | 706 | -46 |
| 1991-09-28 | @ SLN | 153 | L 2-3 | 72-81 | 5 | 38,304 | Greg Maddux | Ken Hill | Ken Hill | Greg Maddux | Lee Smith | 662 | 709 | -47 |
| 1991-09-29 | @ SLN | 154 | W 5-3 | 73-81 | 5 | 42,665 | Rick Sutcliffe | Bryn Smith | Rick Sutcliffe | Bryn Smith | Paul Assenmacher | 667 | 712 | -45 |
| 1991-09-30 | @ PHI | 155 | L 5-6 | 73-82 | 5 | 12,109 | Shawn Boskie | Andy Ashby | Wally Ritchie | Paul Assenmacher | | 672 | 718 | -46 |
| 1991-10-01 | @ PHI | 156 | L 5-6 | 73-83 | 5 | 12,291 | Frank Castillo | Tommy Greene | Bruce Ruffin | Paul Assenmacher | | 677 | 724 | -47 |
| 1991-10-02 | @ PHI | 157 | W 1-0 | 74-83 | 5 | 13,680 | Greg Maddux | Jose De Jesus | Greg Maddux | Jose De Jesus | | 678 | 724 | -46 |
| 1991-10-05 | vs SLN | 158 | W 3-2 | 76-83 | 4 | 0 | Les Lancaster | Ken Hill | Bob Scanlan | Willie Fraser | | 681 | 726 | -45 |
| 1991-10-05 | vs SLN | 159 | W 7-5 | 76-83 | 4 | 21,295 | Shawn Boskie | Mark Clark | Yorkis Perez | Juan Agosto | Paul Assenmacher | 688 | 731 | -43 |
| 1991-10-06 | vs SLN | 160 | W 7-3 | 77-83 | 4 | 17,169 | Greg Maddux | Omar Olivares | Greg Maddux | Omar Olivares | | 695 | 734 | -39 |