| East | W | L | Pct | GB |
| Toronto | 91 | 71 | .562 | -- |
| Boston | 84 | 78 | .519 | 7.0 |
| Detroit | 84 | 78 | .519 | 7.0 |
| Milwaukee | 83 | 79 | .512 | 8.0 |
| NY Yankees | 71 | 91 | .438 | 20.0 |
| Baltimore | 67 | 95 | .414 | 24.0 |
| Cleveland | 57 | 105 | .352 | 34.0 |
| Date | Pitcher | Hand | Age | Game Result | Opp | GS# | Career | Dec | IP | H | R | ER | HR | BB | SO | Pit | Bal | Str | Str% | W-L | ERA | WHIP |
| 1991-04-08 | Roger Clemens | R | 29 | W 6-2 | @ TOR | 1 | 206 | W | 8.0 | 6 | 1 | 1 | 0 | 0 | 6 | 103 | 30 | 73 | 71% | 1-0 | 1.13 | 0.75 |
| 1991-04-09 | Greg Harris | R | 35 | L 3-4 | @ TOR | 1 | 76 | L | 5.1 | 6 | 3 | 3 | 0 | 4 | 2 | 96 | 45 | 51 | 53% | 0-1 | 5.40 | 2.00 |
| 1991-04-10 | Matt Young | L | 33 | L 3-5 | @ TOR | 1 | 132 | - | 5.0 | 3 | 2 | 2 | 0 | 4 | 3 | 74 | 32 | 42 | 57% | 0-0 | 3.60 | 1.40 |
| 1991-04-11 | Danny Darwin | R | 35 | W 4-6 | vs CLE | 1 | 209 | L | 1.2 | 5 | 6 | 6 | 0 | 3 | 1 | 58 | 21 | 37 | 64% | 0-1 | 27.00 | 4.00 |
| 1991-04-13 | Roger Clemens | R | 29 | L 4-0 | vs CLE | 2 | 207 | W | 9.0 | 3 | 0 | 0 | 0 | 0 | 11 | 111 | 41 | 70 | 63% | 2-0 | 0.53 | 0.53 |
| 1991-04-14 | Greg Harris | R | 35 | W 0-6 | vs CLE | 2 | 77 | L | 5.0 | 8 | 3 | 3 | 2 | 2 | 4 | 81 | 31 | 50 | 62% | 0-2 | 5.40 | 2.00 |
| 1991-04-15 | Matt Young | L | 33 | W 0-1 | vs CLE | 2 | 133 | - | 9.0 | 2 | 0 | 0 | 0 | 6 | 4 | 133 | 58 | 75 | 56% | 0-0 | 1.29 | 1.07 |
| 1991-04-16 | Danny Darwin | R | 35 | L 5-2 | vs KCA | 2 | 210 | W | 7.2 | 5 | 2 | 2 | 1 | 1 | 7 | 107 | 32 | 75 | 70% | 1-1 | 8.00 | 1.56 |
| 1991-04-17 | Tom Bolton | L | 29 | L 6-2 | vs KCA | 1 | 21 | W | 7.0 | 6 | 2 | 2 | 0 | 1 | 1 | 103 | 34 | 69 | 67% | 1-0 | 1.50 | 1.17 |
| 1991-04-18 | Roger Clemens | R | 29 | L 1-0 | vs KCA | 3 | 208 | W | 8.0 | 3 | 0 | 0 | 0 | 1 | 10 | 124 | 41 | 83 | 67% | 3-0 | 0.36 | 0.52 |
| 1991-04-20 | Greg Harris | R | 35 | W 2-1 | @ CLE | 3 | 78 | W | 6.0 | 3 | 0 | 0 | 0 | 3 | 3 | 88 | 39 | 49 | 56% | 1-2 | 3.38 | 1.63 |
| 1991-04-22 | Danny Darwin | R | 35 | L 6-4 | vs TOR | 3 | 211 | - | 4.0 | 5 | 4 | 4 | 1 | 0 | 2 | 48 | 14 | 34 | 71% | 1-1 | 8.31 | 1.46 |
| 1991-04-23 | Roger Clemens | R | 29 | L 3-0 | vs TOR | 4 | 209 | W | 7.0 | 5 | 0 | 0 | 0 | 4 | 7 | 109 | 43 | 66 | 61% | 4-0 | 0.28 | 0.69 |
| 1991-04-24 | Matt Young | L | 33 | W 1-6 | vs TOR | 3 | 134 | L | 5.0 | 4 | 5 | 3 | 0 | 5 | 4 | 85 | 45 | 40 | 47% | 0-1 | 2.37 | 1.26 |
| 1991-04-26 | Greg Harris | R | 35 | L 3-5 | @ KCA | 4 | 79 | - | 6.0 | 6 | 3 | 3 | 0 | 2 | 4 | 91 | 35 | 56 | 62% | 1-2 | 3.68 | 1.55 |
| 1991-04-27 | Tom Bolton | L | 29 | W 6-4 | @ KCA | 2 | 22 | W | 6.0 | 4 | 1 | 1 | 0 | 2 | 4 | 100 | 42 | 58 | 58% | 2-0 | 1.50 | 1.11 |
| 1991-04-28 | Dana Kiecker | R | 30 | W 2-1 | @ KCA | 1 | 26 | W | 5.1 | 5 | 1 | 1 | 0 | 1 | 6 | 82 | 30 | 52 | 63% | 1-0 | 3.00 | 1.58 |
| 1991-04-30 | Matt Young | L | 33 | W 7-5 | @ MIN | 4 | 135 | - | 6.1 | 7 | 5 | 5 | 1 | 2 | 3 | 87 | 36 | 51 | 59% | 0-1 | 3.60 | 1.32 |
| 1991-05-01 | Greg Harris | R | 35 | L 0-1 | @ MIN | 5 | 80 | - | 7.0 | 3 | 0 | 0 | 0 | 2 | 6 | 106 | 42 | 64 | 60% | 1-2 | 2.79 | 1.34 |
| 1991-05-03 | Roger Clemens | R | 29 | W 7-2 | @ CHA | 5 | 210 | W | 9.0 | 5 | 2 | 2 | 0 | 2 | 7 | 117 | 41 | 76 | 65% | 5-0 | 0.66 | 0.71 |
| 1991-05-04 | Tom Bolton | L | 29 | W 4-0 | @ CHA | 3 | 23 | W | 6.2 | 4 | 0 | 0 | 0 | 2 | 6 | 77 | 31 | 46 | 60% | 3-0 | 1.08 | 1.04 |
| 1991-05-05 | Matt Young | L | 33 | W 9-1 | @ CHA | 5 | 136 | W | 7.0 | 7 | 1 | 1 | 0 | 3 | 8 | 104 | 39 | 65 | 63% | 1-1 | 3.09 | 1.34 |
| 1991-05-07 | Greg Harris | R | 36 | W 3-9 | vs MIN | 6 | 81 | L | 4.1 | 5 | 3 | 3 | 0 | 3 | 3 | 84 | 39 | 45 | 54% | 1-3 | 3.18 | 1.38 |
| 1991-05-08 | Roger Clemens | R | 29 | L 8-3 | vs MIN | 6 | 211 | W | 8.0 | 4 | 1 | 1 | 0 | 1 | 10 | 95 | 24 | 71 | 75% | 6-0 | 0.73 | 0.69 |
| 1991-05-09 | Tom Bolton | L | 29 | L 8-4 | vs TEX | 4 | 24 | - | 5.2 | 6 | 4 | 4 | 2 | 5 | 4 | 102 | 42 | 60 | 59% | 3-0 | 2.03 | 1.19 |
| 1991-05-10 | Matt Young | L | 33 | L 5-3 | vs TEX | 6 | 137 | W | 6.0 | 8 | 2 | 2 | 0 | 0 | 8 | 100 | 37 | 63 | 63% | 2-1 | 3.08 | 1.34 |
| 1991-05-11 | Dana Kiecker | R | 30 | L 5-4 | vs TEX | 2 | 27 | W | 5.1 | 6 | 4 | 3 | 0 | 4 | 0 | 79 | 34 | 45 | 57% | 2-0 | 4.05 | 1.70 |
| 1991-05-12 | Greg Harris | R | 36 | W 5-12 | vs TEX | 7 | 82 | L | 3.0 | 6 | 7 | 7 | 1 | 2 | 2 | 64 | 24 | 40 | 63% | 1-4 | 4.62 | 1.49 |
| 1991-05-13 | Roger Clemens | R | 29 | W 3-4 | vs CHA | 7 | 212 | - | 8.0 | 5 | 2 | 2 | 0 | 2 | 7 | 106 | 36 | 70 | 66% | 6-0 | 0.95 | 0.72 |
| 1991-05-14 | Tom Bolton | L | 29 | L 4-1 | vs CHA | 5 | 25 | W | 8.1 | 8 | 1 | 0 | 0 | 2 | 5 | 108 | 41 | 67 | 62% | 4-0 | 1.62 | 1.21 |
| 1991-05-15 | Matt Young | L | 33 | L 9-6 | vs CHA | 7 | 138 | - | 3.2 | 6 | 5 | 5 | 0 | 4 | 3 | 86 | 37 | 49 | 57% | 2-1 | 3.86 | 1.45 |
| 1991-05-17 | Greg Harris | R | 36 | L 4-6 | @ TEX | 8 | 83 | L | 2.0 | 6 | 5 | 5 | 0 | 1 | 5 | 50 | 19 | 31 | 62% | 1-5 | 5.54 | 1.59 |
| 1991-05-18 | Roger Clemens | R | 29 | L 5-13 | @ TEX | 8 | 213 | L | 5.0 | 13 | 9 | 9 | 1 | 2 | 4 | 101 | 38 | 63 | 62% | 6-1 | 2.18 | 0.90 |
| 1991-05-19 | Tom Bolton | L | 29 | L 4-12 | @ TEX | 6 | 26 | L | 2.2 | 9 | 7 | 7 | 2 | 3 | 3 | 77 | 38 | 39 | 51% | 4-1 | 3.00 | 1.40 |
| 1991-05-20 | Matt Young | L | 33 | L 3-0 | vs MIL | 8 | 139 | W | 6.0 | 4 | 0 | 0 | 0 | 5 | 4 | 111 | 47 | 64 | 58% | 3-1 | 3.38 | 1.46 |
| 1991-05-21 | Dana Kiecker | R | 30 | L 10-6 | vs MIL | 3 | 28 | - | 3.0 | 6 | 5 | 5 | 1 | 1 | 0 | 54 | 22 | 32 | 59% | 2-0 | 5.25 | 1.83 |
| 1991-05-22 | Danny Darwin | R | 36 | L 4-0 | vs MIL | 4 | 212 | W | 5.0 | 6 | 0 | 0 | 0 | 0 | 4 | 58 | 17 | 41 | 71% | 2-1 | 6.00 | 1.39 |
| 1991-05-23 | Roger Clemens | R | 29 | L 3-5 | @ DET | 9 | 214 | L | 7.0 | 5 | 4 | 4 | 0 | 2 | 10 | 121 | 45 | 76 | 63% | 6-2 | 2.48 | 0.91 |
| 1991-05-24 | Tom Bolton | L | 29 | W 10-9 | @ DET | 7 | 27 | W | 6.1 | 6 | 6 | 5 | 2 | 5 | 4 | 102 | 49 | 53 | 52% | 5-1 | 3.56 | 1.46 |
| 1991-05-25 | Matt Young | L | 33 | L 2-3 | @ DET | 9 | 140 | L | 2.2 | 3 | 3 | 3 | 1 | 3 | 2 | 61 | 33 | 28 | 46% | 3-2 | 3.71 | 1.49 |
| 1991-05-26 | Dana Kiecker | R | 30 | L 4-9 | @ DET | 4 | 29 | L | 1.1 | 5 | 6 | 6 | 3 | 2 | 1 | 34 | 16 | 18 | 53% | 2-1 | 7.20 | 2.04 |
| 1991-05-27 | Danny Darwin | R | 36 | L 5-6 | @ NYA | 5 | 213 | - | 6.2 | 4 | 3 | 3 | 3 | 1 | 3 | 83 | 33 | 50 | 60% | 2-1 | 5.40 | 1.20 |
| 1991-05-28 | Roger Clemens | R | 29 | W 6-2 | @ NYA | 10 | 215 | W | 8.0 | 3 | 1 | 1 | 0 | 1 | 8 | 126 | 39 | 87 | 69% | 7-2 | 2.34 | 0.87 |
| 1991-05-29 | Tom Bolton | L | 29 | L 0-7 | @ NYA | 8 | 28 | L | 5.1 | 5 | 5 | 5 | 2 | 2 | 4 | 90 | 35 | 55 | 61% | 5-2 | 4.08 | 1.45 |
| 1991-05-30 | Matt Young | L | 33 | W 3-9 | vs BAL | 10 | 141 | L | 5.0 | 4 | 5 | 5 | 0 | 5 | 4 | 102 | 45 | 57 | 56% | 3-3 | 4.18 | 1.52 |
| 1991-05-31 | Mike Gardiner | R | 26 | L 7-2 | vs BAL | 1 | 4 | W | 7.0 | 6 | 2 | 2 | 0 | 2 | 5 | 105 | 40 | 65 | 62% | 1-0 | 2.57 | 1.14 |
| 1991-06-01 | Danny Darwin | R | 36 | W 1-3 | vs BAL | 6 | 214 | L | 6.1 | 8 | 3 | 3 | 1 | 1 | 5 | 119 | 37 | 82 | 69% | 2-2 | 5.23 | 1.26 |
| 1991-06-02 | Roger Clemens | R | 29 | W 1-5 | vs BAL | 11 | 216 | L | 8.0 | 8 | 2 | 2 | 0 | 1 | 3 | 124 | 43 | 81 | 65% | 7-3 | 2.33 | 0.89 |
| 1991-06-04 | Tom Bolton | L | 29 | L 0-3 | @ CAL | 9 | 29 | L | 4.0 | 7 | 3 | 2 | 0 | 3 | 4 | 102 | 45 | 57 | 56% | 5-3 | 4.11 | 1.53 |
| 1991-06-05 | Mike Gardiner | R | 26 | L 2-7 | @ CAL | 2 | 5 | L | 4.2 | 6 | 6 | 6 | 1 | 2 | 2 | 75 | 31 | 44 | 59% | 1-1 | 6.00 | 1.33 |
| 1991-06-06 | Danny Darwin | R | 36 | L 2-3 | @ CAL | 7 | 215 | L | 6.1 | 5 | 3 | 3 | 1 | 2 | 2 | 103 | 34 | 69 | 67% | 2-3 | 4.97 | 1.21 |
| 1991-06-07 | Greg Harris | R | 36 | W 3-1 | @ OAK | 9 | 84 | W | 6.0 | 4 | 1 | 1 | 1 | 4 | 3 | 107 | 45 | 62 | 58% | 2-5 | 4.11 | 1.47 |
| 1991-06-08 | Roger Clemens | R | 29 | W 8-1 | @ OAK | 12 | 217 | W | 8.0 | 2 | 1 | 1 | 1 | 2 | 5 | 110 | 42 | 68 | 62% | 8-3 | 2.23 | 0.86 |
| 1991-06-09 | Tom Bolton | L | 29 | L 0-8 | @ OAK | 10 | 30 | L | 1.0 | 7 | 4 | 4 | 0 | 1 | 0 | 43 | 21 | 22 | 51% | 5-4 | 4.66 | 1.64 |
| 1991-06-10 | Mike Gardiner | R | 26 | W 6-2 | @ SEA | 3 | 6 | W | 6.2 | 6 | 1 | 1 | 0 | 2 | 7 | 122 | 45 | 77 | 63% | 2-1 | 4.50 | 1.33 |
| 1991-06-11 | Danny Darwin | R | 36 | W 8-5 | @ SEA | 8 | 216 | W | 5.0 | 7 | 4 | 4 | 1 | 1 | 2 | 84 | 31 | 53 | 63% | 3-3 | 5.23 | 1.26 |
| 1991-06-12 | Greg Harris | R | 36 | L 3-5 | @ SEA | 10 | 85 | L | 6.2 | 5 | 5 | 5 | 1 | 3 | 6 | 100 | 42 | 58 | 58% | 2-6 | 4.36 | 1.44 |
| 1991-06-14 | Roger Clemens | R | 29 | L 9-4 | vs CAL | 13 | 218 | W | 9.0 | 8 | 3 | 2 | 0 | 0 | 7 | 118 | 37 | 81 | 69% | 9-3 | 2.21 | 0.86 |
| 1991-06-15 | Mike Gardiner | R | 26 | L 13-3 | vs CAL | 4 | 7 | W | 8.0 | 5 | 3 | 1 | 0 | 1 | 3 | 108 | 38 | 70 | 65% | 3-1 | 3.46 | 1.15 |
| 1991-06-16 | Tom Bolton | L | 29 | L 2-0 | vs CAL | 11 | 31 | W | 8.0 | 5 | 0 | 0 | 0 | 1 | 3 | 96 | 35 | 61 | 64% | 6-4 | 4.03 | 1.52 |
| 1991-06-17 | Greg Harris | R | 36 | W 2-4 | vs CAL | 11 | 86 | L | 7.0 | 7 | 4 | 4 | 0 | 0 | 9 | 104 | 31 | 73 | 70% | 2-7 | 4.44 | 1.39 |
| 1991-06-18 | Danny Darwin | R | 36 | W 1-2 | vs SEA | 9 | 217 | - | 7.2 | 5 | 0 | 0 | 0 | 1 | 4 | 110 | 40 | 70 | 64% | 3-3 | 4.50 | 1.20 |
| 1991-06-19 | Roger Clemens | R | 29 | W 3-4 | vs SEA | 14 | 219 | L | 7.2 | 9 | 4 | 1 | 0 | 6 | 3 | 116 | 47 | 69 | 59% | 9-4 | 2.13 | 0.94 |
| 1991-06-20 | Mike Gardiner | R | 26 | L 8-7 | vs OAK | 5 | 8 | - | 4.2 | 8 | 5 | 5 | 2 | 4 | 6 | 101 | 41 | 60 | 59% | 3-1 | 4.35 | 1.35 |
| 1991-06-21 | Tom Bolton | L | 29 | L 3-2 | vs OAK | 12 | 32 | W | 7.0 | 10 | 2 | 2 | 1 | 3 | 2 | 115 | 50 | 65 | 57% | 7-4 | 3.89 | 1.55 |
| 1991-06-22 | Greg Harris | R | 36 | L 9-5 | vs OAK | 12 | 87 | W | 6.1 | 5 | 3 | 3 | 0 | 3 | 5 | 103 | 48 | 55 | 53% | 3-7 | 4.44 | 1.39 |
| 1991-06-23 | Danny Darwin | R | 36 | W 2-4 | vs OAK | 10 | 218 | L | 7.1 | 8 | 4 | 4 | 3 | 1 | 3 | 113 | 39 | 74 | 65% | 3-4 | 4.50 | 1.19 |
| 1991-06-25 | Roger Clemens | R | 29 | W 4-6 | vs NYA | 15 | 220 | L | 9.0 | 10 | 6 | 3 | 1 | 2 | 8 | 141 | 48 | 93 | 66% | 9-5 | 2.19 | 0.97 |
| 1991-06-26 | Mike Gardiner | R | 26 | W 1-5 | vs NYA | 6 | 9 | L | 5.1 | 9 | 5 | 5 | 0 | 2 | 6 | 97 | 35 | 62 | 64% | 3-2 | 5.00 | 1.47 |
| 1991-06-27 | Tom Bolton | L | 29 | W 0-8 | vs NYA | 13 | 33 | L | 3.2 | 10 | 8 | 8 | 3 | 2 | 0 | 78 | 31 | 47 | 60% | 7-5 | 4.62 | 1.63 |
| 1991-06-28 | Greg Harris | R | 36 | W 9-3 | @ BAL | 13 | 88 | W | 6.2 | 6 | 3 | 3 | 0 | 2 | 6 | 107 | 35 | 72 | 67% | 4-7 | 4.39 | 1.37 |
| 1991-06-29 | Danny Darwin | R | 36 | L 3-7 | @ BAL | 11 | 219 | L | 5.1 | 5 | 5 | 5 | 2 | 3 | 2 | 97 | 33 | 64 | 66% | 3-5 | 4.86 | 1.22 |
| 1991-06-30 | Joe Hesketh | L | 32 | L 4-6 | @ BAL | 1 | 48 | L | 5.0 | 9 | 5 | 4 | 2 | 2 | 5 | 79 | 28 | 51 | 65% | 2-1 | 4.09 | 1.59 |
| 1991-07-01 | Roger Clemens | R | 29 | W 6-0 | @ MIL | 16 | 221 | W | 7.0 | 5 | 0 | 0 | 0 | 1 | 8 | 113 | 36 | 77 | 68% | 10-5 | 2.07 | 0.96 |
| 1991-07-02 | Tom Bolton | L | 29 | W 14-4 | @ MIL | 14 | 34 | - | 4.0 | 7 | 3 | 3 | 0 | 5 | 1 | 74 | 36 | 38 | 51% | 7-5 | 4.72 | 1.70 |
| 1991-07-03 | Greg Harris | R | 36 | W 5-3 | @ MIL | 14 | 89 | W | 6.1 | 7 | 3 | 3 | 0 | 0 | 5 | 98 | 32 | 66 | 67% | 5-7 | 4.40 | 1.36 |
| 1991-07-04 | Danny Darwin | R | 36 | W 1-6 | vs DET | 12 | 220 | L | 5.0 | 8 | 5 | 5 | 2 | 1 | 7 | 100 | 29 | 71 | 71% | 3-6 | 5.16 | 1.26 |
| 1991-07-05 | Kevin Morton | L | 23 | L 10-1 | vs DET | 1 | 1 | W | 9.0 | 5 | 1 | 1 | 1 | 1 | 9 | 102 | 33 | 69 | 68% | 1-0 | 1.00 | 0.67 |
| 1991-07-06 | Roger Clemens | R | 29 | L 7-4 | vs DET | 17 | 222 | W | 8.0 | 11 | 4 | 4 | 2 | 2 | 9 | 129 | 45 | 84 | 65% | 11-5 | 2.22 | 1.00 |
| 1991-07-07 | Tom Bolton | L | 29 | W 6-7 | vs DET | 15 | 35 | L | 3.2 | 8 | 5 | 1 | 1 | 2 | 3 | 74 | 36 | 38 | 51% | 7-6 | 4.60 | 1.73 |
| 1991-07-11 | Greg Harris | R | 36 | L 3-7 | @ MIN | 15 | 90 | L | 6.0 | 5 | 4 | 4 | 1 | 2 | 2 | 91 | 33 | 58 | 64% | 5-8 | 4.64 | 1.36 |
| 1991-07-12 | Roger Clemens | R | 29 | L 4-5 | @ MIN | 18 | 223 | L | 6.1 | 11 | 5 | 4 | 1 | 2 | 6 | 130 | 57 | 73 | 56% | 11-6 | 2.38 | 1.05 |
| 1991-07-13 | Kevin Morton | L | 23 | L 1-3 | @ MIN | 2 | 2 | L | 5.2 | 9 | 3 | 3 | 0 | 3 | 2 | 102 | 45 | 57 | 56% | 1-1 | 2.40 | 1.20 |
| 1991-07-14 | Joe Hesketh | L | 32 | W 5-3 | @ MIN | 2 | 49 | W | 7.0 | 7 | 2 | 2 | 0 | 0 | 4 | 92 | 33 | 59 | 64% | 3-1 | 3.76 | 1.47 |
| 1991-07-15 | Mike Gardiner | R | 26 | L 1-7 | @ CHA | 7 | 10 | L | 5.0 | 9 | 3 | 3 | 2 | 2 | 4 | 95 | 31 | 64 | 67% | 3-3 | 5.05 | 1.56 |
| 1991-07-16 | Greg Harris | R | 36 | W 2-0 | @ CHA | 16 | 91 | W | 7.0 | 2 | 0 | 0 | 0 | 0 | 3 | 75 | 29 | 46 | 61% | 6-8 | 4.33 | 1.29 |
| 1991-07-17 | Roger Clemens | R | 29 | W 4-2 | @ CHA | 19 | 224 | - | 7.0 | 2 | 1 | 1 | 0 | 2 | 3 | 85 | 37 | 48 | 56% | 11-6 | 2.33 | 1.03 |
| 1991-07-18 | Kevin Morton | L | 23 | W 3-11 | vs MIN | 3 | 3 | L | 2.1 | 6 | 6 | 6 | 0 | 1 | 2 | 46 | 21 | 25 | 54% | 1-2 | 5.29 | 1.47 |
| 1991-07-19 | Joe Hesketh | L | 32 | W 2-3 | vs MIN | 3 | 50 | - | 6.1 | 9 | 1 | 1 | 0 | 2 | 5 | 94 | 32 | 62 | 66% | 3-1 | 3.48 | 1.48 |
| 1991-07-20 | Mike Gardiner | R | 26 | W 0-5 | vs MIN | 8 | 11 | L | 7.1 | 5 | 3 | 2 | 1 | 4 | 2 | 106 | 42 | 64 | 60% | 3-4 | 4.59 | 1.49 |
| 1991-07-21 | Tom Bolton | L | 29 | W 1-14 | vs MIN | 16 | 36 | L | 2.2 | 5 | 5 | 4 | 0 | 3 | 1 | 48 | 22 | 26 | 54% | 7-7 | 4.74 | 1.72 |
| 1991-07-22 | Roger Clemens | R | 29 | L 1-2 | @ TEX | 20 | 225 | L | 8.0 | 7 | 2 | 2 | 1 | 4 | 4 | 162 | 72 | 90 | 56% | 11-7 | 2.32 | 1.05 |
| 1991-07-23 | Greg Harris | R | 36 | L 4-5 | @ TEX | 17 | 92 | L | 4.1 | 7 | 5 | 5 | 0 | 3 | 4 | 89 | 37 | 52 | 58% | 6-10 | 4.58 | 1.33 |
| 1991-07-24 | Joe Hesketh | L | 32 | W 2-1 | @ TEX | 4 | 51 | W | 6.2 | 2 | 1 | 1 | 1 | 2 | 4 | 82 | 30 | 52 | 63% | 4-1 | 3.31 | 1.41 |
| 1991-07-27 | Roger Clemens | R | 29 | W 8-10 | vs CHA | 21 | 226 | - | 6.0 | 6 | 5 | 4 | 0 | 2 | 6 | 116 | 41 | 75 | 65% | 11-7 | 2.46 | 1.06 |
| 1991-07-27 | Mike Gardiner | R | 26 | W 4-7 | vs CHA | 9 | 12 | L | 5.0 | 8 | 5 | 3 | 0 | 4 | 3 | 100 | 43 | 57 | 57% | 3-5 | 4.67 | 1.57 |
| 1991-07-28 | Greg Harris | R | 36 | W 2-5 | vs CHA | 18 | 93 | L | 7.1 | 7 | 4 | 3 | 1 | 2 | 3 | 110 | 43 | 67 | 61% | 6-11 | 4.50 | 1.31 |
| 1991-07-29 | Joe Hesketh | L | 32 | W 2-7 | vs TEX | 5 | 52 | L | 6.2 | 11 | 5 | 5 | 2 | 0 | 4 | 104 | 35 | 69 | 66% | 4-2 | 3.60 | 1.43 |
| 1991-07-30 | Kevin Morton | L | 23 | L 11-6 | vs TEX | 4 | 4 | W | 6.1 | 8 | 4 | 4 | 3 | 4 | 4 | 125 | 50 | 75 | 60% | 2-2 | 6.00 | 1.79 |
| 1991-07-31 | Dana Kiecker | R | 30 | L 11-10 | vs OAK | 5 | 30 | - | 5.0 | 8 | 7 | 7 | 1 | 3 | 4 | 85 | 38 | 47 | 55% | 2-2 | 8.16 | 2.13 |
| 1991-08-01 | Mike Gardiner | R | 26 | W 2-4 | vs OAK | 10 | 13 | - | 7.0 | 8 | 2 | 2 | 1 | 3 | 4 | 99 | 39 | 60 | 61% | 3-5 | 4.43 | 1.57 |
| 1991-08-02 | Roger Clemens | R | 29 | L 5-3 | vs TOR | 22 | 227 | W | 9.0 | 5 | 3 | 3 | 2 | 1 | 9 | 128 | 40 | 88 | 69% | 12-7 | 2.49 | 1.04 |
| 1991-08-03 | Joe Hesketh | L | 32 | L 4-1 | vs TOR | 6 | 53 | W | 7.2 | 4 | 0 | 0 | 0 | 2 | 8 | 107 | 44 | 63 | 59% | 5-2 | 3.25 | 1.36 |
| 1991-08-04 | Greg Harris | R | 36 | W 1-2 | vs TOR | 19 | 94 | - | 5.0 | 5 | 1 | 1 | 0 | 4 | 5 | 78 | 33 | 45 | 58% | 7-11 | 4.25 | 1.30 |
| 1991-08-05 | Kevin Morton | L | 23 | L 3-5 | @ KCA | 5 | 5 | - | 5.1 | 5 | 2 | 1 | 0 | 3 | 2 | 75 | 33 | 42 | 56% | 2-2 | 5.28 | 1.76 |
| 1991-08-06 | Mike Gardiner | R | 26 | L 0-6 | @ KCA | 11 | 14 | L | 5.0 | 9 | 6 | 6 | 1 | 2 | 0 | 83 | 32 | 51 | 61% | 3-6 | 4.91 | 1.62 |
| 1991-08-07 | Roger Clemens | R | 29 | L 0-2 | @ KCA | 23 | 228 | L | 8.0 | 7 | 2 | 2 | 0 | 3 | 7 | 118 | 47 | 71 | 60% | 12-8 | 2.48 | 1.04 |
| 1991-08-09 | Joe Hesketh | L | 32 | W 12-7 | @ TOR | 7 | 54 | W | 5.0 | 7 | 4 | 4 | 3 | 0 | 1 | 72 | 21 | 51 | 71% | 6-2 | 3.48 | 1.36 |
| 1991-08-10 | Greg Harris | R | 36 | W 7-1 | @ TOR | 20 | 95 | W | 9.0 | 4 | 1 | 1 | 0 | 1 | 7 | 107 | 33 | 74 | 69% | 8-11 | 4.04 | 1.25 |
| 1991-08-11 | Mike Gardiner | R | 26 | W 9-6 | @ TOR | 12 | 15 | W | 6.0 | 5 | 4 | 4 | 2 | 2 | 5 | 104 | 45 | 59 | 57% | 4-6 | 5.00 | 1.58 |
| 1991-08-12 | Roger Clemens | R | 29 | W 11-8 | @ TOR | 24 | 229 | - | 4.1 | 9 | 7 | 5 | 1 | 4 | 1 | 98 | 44 | 54 | 55% | 12-8 | 2.67 | 1.09 |
| 1991-08-13 | Matt Young | L | 33 | L 6-8 | @ CLE | 11 | 142 | - | 4.2 | 9 | 6 | 6 | 0 | 1 | 5 | 91 | 36 | 55 | 60% | 3-3 | 4.57 | 1.56 |
| 1991-08-13 | Kevin Morton | L | 23 | W 7-5 | @ CLE | 6 | 6 | - | 5.0 | 8 | 5 | 5 | 0 | 3 | 2 | 89 | 31 | 58 | 65% | 2-2 | 5.82 | 1.82 |
| 1991-08-14 | Joe Hesketh | L | 32 | W 2-1 | @ CLE | 8 | 55 | W | 7.0 | 6 | 1 | 1 | 0 | 1 | 3 | 104 | 38 | 66 | 63% | 7-2 | 3.32 | 1.34 |
| 1991-08-15 | Mike Gardiner | R | 26 | W 6-2 | @ CLE | 13 | 16 | W | 6.0 | 5 | 1 | 1 | 0 | 1 | 4 | 97 | 37 | 60 | 62% | 5-6 | 4.73 | 1.54 |
| 1991-08-16 | Roger Clemens | R | 29 | L 3-2 | vs KCA | 25 | 230 | - | 7.0 | 5 | 1 | 1 | 0 | 3 | 5 | 102 | 39 | 63 | 62% | 12-8 | 2.62 | 1.10 |
| 1991-08-17 | Matt Young | L | 33 | W 3-4 | vs KCA | 12 | 143 | - | 7.0 | 8 | 2 | 1 | 0 | 1 | 4 | 99 | 37 | 62 | 63% | 3-3 | 4.24 | 1.53 |
| 1991-08-18 | Kevin Morton | L | 23 | L 5-1 | vs KCA | 7 | 7 | W | 7.2 | 7 | 1 | 1 | 0 | 2 | 5 | 110 | 39 | 71 | 65% | 3-2 | 4.93 | 1.69 |
| 1991-08-21 | Joe Hesketh | L | 33 | L 13-5 | vs CLE | 9 | 56 | W | 6.0 | 2 | 1 | 1 | 1 | 1 | 2 | 66 | 25 | 41 | 62% | 8-2 | 3.21 | 1.29 |
| 1991-08-21 | Roger Clemens | R | 29 | L 5-4 | vs CLE | 26 | 231 | - | 7.0 | 8 | 4 | 4 | 0 | 3 | 9 | 135 | 53 | 82 | 61% | 12-8 | 2.71 | 1.11 |
| 1991-08-22 | Mike Gardiner | R | 26 | L 7-6 | vs CLE | 14 | 17 | - | 7.1 | 7 | 6 | 5 | 3 | 1 | 8 | 112 | 30 | 82 | 73% | 5-6 | 4.87 | 1.51 |
| 1991-08-23 | Matt Young | L | 33 | L 1-4 | @ CAL | 13 | 144 | L | 6.1 | 6 | 3 | 3 | 1 | 6 | 5 | 120 | 63 | 57 | 48% | 3-4 | 4.21 | 1.55 |
| 1991-08-24 | Kevin Morton | L | 23 | L 0-1 | @ CAL | 8 | 8 | L | 7.0 | 2 | 1 | 1 | 1 | 3 | 4 | 101 | 43 | 58 | 57% | 3-3 | 4.41 | 1.55 |
| 1991-08-25 | Joe Hesketh | L | 33 | L 5-9 | @ CAL | 10 | 57 | L | 4.1 | 7 | 7 | 7 | 2 | 2 | 1 | 77 | 32 | 45 | 58% | 8-3 | 3.69 | 1.32 |
| 1991-08-26 | Roger Clemens | R | 29 | W 3-0 | @ OAK | 27 | 232 | W | 9.0 | 3 | 0 | 0 | 0 | 1 | 10 | 135 | 50 | 85 | 63% | 13-8 | 2.59 | 1.08 |
| 1991-08-27 | Mike Gardiner | R | 26 | W 6-4 | @ OAK | 15 | 18 | W | 5.0 | 4 | 4 | 4 | 1 | 2 | 7 | 92 | 33 | 59 | 64% | 6-6 | 5.00 | 1.49 |
| 1991-08-28 | Matt Young | L | 33 | L 3-9 | @ OAK | 14 | 145 | L | 4.0 | 8 | 6 | 6 | 0 | 0 | 5 | 75 | 22 | 53 | 71% | 3-5 | 4.67 | 1.57 |
| 1991-08-30 | Joe Hesketh | L | 33 | W 3-2 | @ SEA | 11 | 58 | W | 8.0 | 7 | 2 | 2 | 0 | 0 | 5 | 106 | 36 | 70 | 66% | 9-3 | 3.58 | 1.29 |
| 1991-08-31 | Roger Clemens | R | 29 | W 4-1 | @ SEA | 28 | 233 | W | 9.0 | 4 | 1 | 1 | 1 | 3 | 8 | 135 | 54 | 81 | 60% | 14-8 | 2.52 | 1.07 |
| 1991-09-01 | Kevin Morton | L | 23 | W 13-2 | @ SEA | 9 | 9 | W | 7.0 | 7 | 2 | 2 | 0 | 4 | 2 | 118 | 51 | 67 | 57% | 4-3 | 4.18 | 1.55 |
| 1991-09-03 | Mike Gardiner | R | 26 | W 0-2 | vs CAL | 16 | 19 | L | 5.1 | 6 | 2 | 1 | 0 | 2 | 7 | 96 | 39 | 57 | 59% | 6-7 | 4.83 | 1.49 |
| 1991-09-04 | Joe Hesketh | L | 33 | L 2-0 | vs CAL | 12 | 59 | W | 5.2 | 6 | 0 | 0 | 0 | 2 | 6 | 96 | 34 | 62 | 65% | 10-3 | 3.40 | 1.29 |
| 1991-09-05 | Roger Clemens | R | 29 | L 4-3 | vs SEA | 29 | 234 | - | 9.0 | 9 | 3 | 3 | 1 | 1 | 7 | 121 | 48 | 73 | 60% | 14-8 | 2.54 | 1.07 |
| 1991-09-06 | Matt Young | L | 33 | L 6-5 | vs SEA | 15 | 146 | - | 3.2 | 6 | 5 | 5 | 1 | 2 | 2 | 68 | 30 | 38 | 56% | 3-5 | 5.04 | 1.61 |
| 1991-09-07 | Kevin Morton | L | 23 | L 11-10 | vs SEA | 10 | 10 | - | 0.2 | 3 | 5 | 5 | 0 | 3 | 1 | 32 | 15 | 17 | 53% | 4-3 | 4.89 | 1.63 |
| 1991-09-08 | Mike Gardiner | R | 26 | L 17-6 | vs SEA | 17 | 20 | W | 6.0 | 6 | 4 | 4 | 0 | 1 | 2 | 88 | 29 | 59 | 67% | 7-7 | 4.90 | 1.48 |
| 1991-09-09 | Joe Hesketh | L | 33 | W 4-3 | @ CLE | 13 | 60 | - | 6.2 | 5 | 2 | 2 | 0 | 1 | 4 | 96 | 34 | 62 | 65% | 10-3 | 3.38 | 1.28 |
| 1991-09-10 | Roger Clemens | R | 29 | W 4-0 | @ DET | 30 | 235 | W | 9.0 | 2 | 0 | 0 | 0 | 1 | 6 | 109 | 34 | 75 | 69% | 15-8 | 2.44 | 1.04 |
| 1991-09-11 | Matt Young | L | 33 | L 2-8 | @ DET | 16 | 147 | L | 3.2 | 5 | 3 | 2 | 0 | 2 | 3 | 72 | 30 | 42 | 58% | 3-6 | 5.01 | 1.61 |
| 1991-09-12 | Kevin Morton | L | 23 | W 7-2 | @ NYA | 11 | 11 | W | 6.2 | 5 | 2 | 2 | 1 | 1 | 2 | 106 | 36 | 70 | 66% | 5-3 | 4.71 | 1.57 |
| 1991-09-13 | Mike Gardiner | R | 26 | W 5-4 | @ NYA | 18 | 21 | W | 5.0 | 6 | 3 | 3 | 1 | 3 | 3 | 80 | 28 | 52 | 65% | 8-7 | 4.92 | 1.49 |
| 1991-09-14 | Joe Hesketh | L | 33 | L 1-3 | @ NYA | 14 | 61 | L | 7.0 | 9 | 3 | 2 | 0 | 2 | 1 | 108 | 41 | 67 | 62% | 10-4 | 3.34 | 1.30 |
| 1991-09-15 | Roger Clemens | R | 29 | W 5-4 | @ NYA | 31 | 236 | W | 7.0 | 8 | 4 | 4 | 0 | 0 | 6 | 96 | 32 | 64 | 67% | 16-8 | 2.52 | 1.05 |
| 1991-09-16 | Tom Bolton | L | 29 | W 2-9 | vs BAL | 17 | 37 | L | 3.0 | 5 | 4 | 4 | 2 | 1 | 4 | 64 | 25 | 39 | 61% | 8-8 | 4.90 | 1.70 |
| 1991-09-17 | Kevin Morton | L | 23 | L 4-3 | vs BAL | 12 | 12 | W | 6.0 | 6 | 3 | 3 | 2 | 1 | 4 | 97 | 37 | 60 | 62% | 6-3 | 4.70 | 1.54 |
| 1991-09-18 | Mike Gardiner | R | 26 | L 7-5 | vs BAL | 19 | 22 | W | 5.2 | 7 | 4 | 3 | 2 | 1 | 3 | 87 | 35 | 52 | 60% | 9-7 | 4.90 | 1.48 |
| 1991-09-20 | Roger Clemens | R | 29 | L 2-0 | vs NYA | 32 | 237 | W | 9.0 | 3 | 0 | 0 | 0 | 2 | 7 | 110 | 41 | 69 | 63% | 17-8 | 2.43 | 1.03 |
| 1991-09-21 | Joe Hesketh | L | 33 | L 12-1 | vs NYA | 15 | 62 | W | 8.0 | 4 | 1 | 1 | 1 | 3 | 4 | 111 | 43 | 68 | 61% | 11-4 | 3.21 | 1.27 |
| 1991-09-22 | Kevin Morton | L | 23 | W 5-7 | vs NYA | 13 | 13 | - | 4.2 | 6 | 2 | 2 | 0 | 3 | 0 | 66 | 26 | 40 | 61% | 6-3 | 4.62 | 1.55 |
| 1991-09-23 | Mike Gardiner | R | 26 | L 3-4 | @ BAL | 20 | 23 | L | 6.0 | 4 | 4 | 3 | 0 | 3 | 4 | 122 | 51 | 71 | 58% | 9-8 | 4.88 | 1.47 |
| 1991-09-26 | Roger Clemens | R | 29 | W 2-1 | @ BAL | 33 | 238 | W | 9.0 | 7 | 1 | 1 | 0 | 0 | 10 | 119 | 39 | 80 | 67% | 18-8 | 2.38 | 1.02 |
| 1991-09-26 | Joe Hesketh | L | 33 | L 5-6 | @ BAL | 16 | 63 | - | 5.2 | 7 | 3 | 3 | 1 | 1 | 4 | 101 | 35 | 66 | 65% | 11-4 | 3.27 | 1.27 |
| 1991-09-27 | Kevin Morton | L | 23 | L 5-7 | @ MIL | 14 | 14 | L | 5.2 | 5 | 6 | 6 | 0 | 2 | 2 | 87 | 35 | 52 | 60% | 6-4 | 4.95 | 1.53 |
| 1991-09-28 | Mike Gardiner | R | 26 | L 1-4 | @ MIL | 21 | 24 | L | 5.1 | 5 | 3 | 3 | 0 | 1 | 5 | 84 | 26 | 58 | 69% | 9-9 | 4.90 | 1.46 |
| 1991-09-29 | Tom Bolton | L | 29 | L 4-5 | @ MIL | 18 | 38 | - | 5.2 | 3 | 3 | 3 | 0 | 3 | 3 | 104 | 43 | 61 | 59% | 8-8 | 4.88 | 1.66 |
| 1991-09-30 | Greg Harris | R | 36 | W 9-8 | @ MIL | 21 | 96 | - | 4.1 | 8 | 7 | 4 | 2 | 1 | 4 | 73 | 24 | 49 | 67% | 11-12 | 3.81 | 1.30 |
| 1991-10-01 | Roger Clemens | R | 29 | W 5-8 | vs DET | 34 | 239 | L | 5.0 | 5 | 6 | 6 | 3 | 2 | 4 | 90 | 40 | 50 | 56% | 18-9 | 2.54 | 1.03 |
| 1991-10-02 | Joe Hesketh | L | 33 | L 5-3 | vs DET | 17 | 64 | W | 7.1 | 5 | 3 | 3 | 0 | 4 | 9 | 119 | 45 | 74 | 62% | 12-4 | 3.29 | 1.27 |
| 1991-10-03 | Kevin Morton | L | 23 | W 5-10 | vs DET | 15 | 15 | L | 6.2 | 8 | 4 | 0 | 1 | 3 | 4 | 101 | 43 | 58 | 57% | 6-5 | 4.60 | 1.55 |
| 1991-10-04 | Mike Gardiner | R | 26 | W 2-3 | vs MIL | 22 | 25 | L | 6.2 | 6 | 3 | 3 | 1 | 2 | 1 | 79 | 31 | 48 | 61% | 9-10 | 4.85 | 1.44 |
| 1991-10-05 | Tom Bolton | L | 29 | W 4-13 | vs MIL | 19 | 39 | L | 3.0 | 7 | 6 | 6 | 0 | 2 | 1 | 68 | 22 | 46 | 68% | 8-9 | 5.24 | 1.70 |
| 1991-10-06 | Roger Clemens | R | 29 | W 3-6 | vs MIL | 35 | 240 | L | 9.0 | 13 | 6 | 5 | 0 | 2 | 10 | 143 | 56 | 87 | 61% | 18-10 | 2.62 | 1.05 |