| 1991-04-08 | vs CHA | 1 | L 1-9 | 0-1 | 4 | 50,213 | Jeff Ballard | Jack McDowell | Jack McDowell | Jeff Ballard | | 1 | 9 | -8 |
| 1991-04-10 | vs CHA | 2 | L 0-2 | 0-2 | 7 | 24,973 | Jose Mesa | Greg Hibbard | Greg Hibbard | Jose Mesa | Bobby Thigpen | 1 | 11 | -10 |
| 1991-04-12 | @ TEX | 3 | W 3-0 | 1-2 | 5 | 15,932 | Dave Johnson | Bobby Witt | Dave Johnson | Bobby Witt | Gregg Olson | 4 | 11 | -7 |
| 1991-04-13 | @ TEX | 4 | W 11-4 | 2-2 | 3 | 23,632 | Jeff Ballard | Kenny Rogers | Jeff Ballard | Kenny Rogers | | 15 | 15 | 0 |
| 1991-04-14 | @ TEX | 5 | L 3-15 | 2-3 | 4 | 24,084 | Jeff Robinson | Nolan Ryan | Nolan Ryan | Jeff Robinson | | 18 | 30 | -12 |
| 1991-04-15 | @ MIL | 6 | W 7-2 | 3-3 | 3 | 50,058 | Jose Mesa | Chris Bosio | Jose Mesa | Chris Bosio | Mark Williamson | 25 | 32 | -7 |
| 1991-04-17 | @ MIL | 7 | L 3-7 | 3-4 | 6 | 8,053 | Dave Johnson | Jaime Navarro | Jaime Navarro | Dave Johnson | Mark Lee | 28 | 39 | -11 |
| 1991-04-18 | @ MIL | 8 | L 3-4 | 3-5 | 6 | 7,693 | Jeff Ballard | Mark Knudson | Ed Nunez | Jose Bautista | | 31 | 43 | -12 |
| 1991-04-19 | vs TEX | 9 | W 5-0 | 4-5 | 5 | 21,834 | Jeff Robinson | Kenny Rogers | Jeff Robinson | Kenny Rogers | | 36 | 43 | -7 |
| 1991-04-20 | vs TEX | 10 | L 0-1 | 4-6 | 5 | 22,448 | Jose Mesa | Nolan Ryan | Nolan Ryan | Jose Mesa | Jeff Russell | 36 | 44 | -8 |
| 1991-04-22 | @ CHA | 11 | L 7-8 | 4-7 | 6 | 30,480 | Ben McDonald | Alex Fernandez | Alex Fernandez | Ben McDonald | Bobby Thigpen | 43 | 52 | -9 |
| 1991-04-23 | @ CHA | 12 | L 4-10 | 4-8 | 7 | 23,215 | Dave Johnson | Jack McDowell | Jack McDowell | Dave Johnson | | 47 | 62 | -15 |
| 1991-04-24 | @ CHA | 13 | W 5-1 | 5-8 | 5 | 26,121 | Jeff Ballard | Charlie Hough | Jeff Ballard | Charlie Hough | | 52 | 63 | -11 |
| 1991-04-26 | vs MIL | 14 | L 4-5 | 5-9 | 7 | 28,657 | Jose Mesa | Kevin Brown | Darren Holmes | Jose Mesa | Ed Nunez | 56 | 68 | -12 |
| 1991-04-27 | vs MIL | 15 | L 2-5 | 5-10 | 7 | 31,488 | Jeff Robinson | Don August | Don August | Jeff Robinson | | 58 | 73 | -15 |
| 1991-04-28 | vs MIL | 16 | W 5-4 | 6-10 | 6 | 32,989 | Ben McDonald | Jaime Navarro | Bob Milacki | Darren Holmes | Gregg Olson | 63 | 77 | -14 |
| 1991-04-29 | vs SEA | 17 | L 1-10 | 6-11 | 7 | 18,892 | Dave Johnson | Rich DeLucia | Rich DeLucia | Dave Johnson | | 64 | 87 | -23 |
| 1991-04-30 | vs SEA | 18 | L 3-6 | 6-12 | 7 | 18,743 | Jeff Ballard | Erik Hanson | Erik Hanson | Jeff Ballard | Russ Swan | 67 | 93 | -26 |
| 1991-05-01 | vs SEA | 19 | W 2-1 | 7-12 | 6 | 19,918 | Jose Mesa | Randy Johnson | Jose Mesa | Randy Johnson | Gregg Olson | 69 | 94 | -25 |
| 1991-05-03 | @ CAL | 20 | W 2-0 | 8-12 | 6 | 37,085 | Ben McDonald | Kirk McCaskill | Ben McDonald | Kirk McCaskill | Gregg Olson | 71 | 94 | -23 |
| 1991-05-04 | @ CAL | 21 | L 3-6 | 8-13 | 6 | 29,612 | Jeff Robinson | Mark Langston | Mark Langston | Jeff Robinson | Bryan Harvey | 74 | 100 | -26 |
| 1991-05-05 | @ CAL | 22 | L 4-6 | 8-14 | 6 | 41,103 | Jeff Ballard | Jim Abbott | Jim Abbott | Jeff Ballard | Bryan Harvey | 78 | 106 | -28 |
| 1991-05-06 | @ CAL | 23 | W 7-0 | 9-14 | 6 | 19,972 | Jose Mesa | Scott Lewis | Jose Mesa | Scott Lewis | | 85 | 106 | -21 |
| 1991-05-07 | @ OAK | 24 | L 3-11 | 9-15 | 6 | 22,908 | Ben McDonald | Mike Moore | Mike Moore | Ben McDonald | | 88 | 117 | -29 |
| 1991-05-08 | @ OAK | 25 | L 3-9 | 9-16 | 6 | 23,528 | Mike Flanagan | Dave Stewart | Curt Young | Mike Flanagan | | 91 | 126 | -35 |
| 1991-05-10 | @ SEA | 26 | L 1-3 | 9-17 | 7 | 24,553 | Jeff Ballard | Scott Bankhead | Rich DeLucia | Jeff Ballard | Michael Jackson | 92 | 129 | -37 |
| 1991-05-11 | @ SEA | 27 | W 11-5 | 10-17 | 6 | 26,338 | Jose Mesa | Erik Hanson | Jose Mesa | Bill Krueger | | 103 | 134 | -31 |
| 1991-05-12 | @ SEA | 28 | L 4-5 | 10-18 | 7 | 16,484 | Ben McDonald | Randy Johnson | Michael Jackson | Gregg Olson | | 107 | 139 | -32 |
| 1991-05-14 | vs OAK | 29 | W 6-1 | 11-18 | 7 | 24,006 | Jeff Robinson | Joe Slusarski | Jeff Robinson | Joe Slusarski | | 113 | 140 | -27 |
| 1991-05-15 | vs OAK | 30 | L 3-6 | 11-19 | 7 | 32,596 | Jeff Ballard | Bob Welch | Bob Welch | Jeff Ballard | Dennis Eckersley | 116 | 146 | -30 |
| 1991-05-16 | vs OAK | 31 | L 5-11 | 11-20 | 7 | 32,414 | Jose Mesa | Kirk Dressendorfer | Joe Klink | Jose Mesa | | 121 | 157 | -36 |
| 1991-05-17 | vs CAL | 32 | W 5-1 | 12-20 | 6 | 34,209 | Ben McDonald | Scott Lewis | Ben McDonald | Scott Lewis | | 126 | 158 | -32 |
| 1991-05-18 | vs CAL | 33 | L 2-4 | 12-21 | 6 | 31,728 | Jeff Robinson | Chuck Finley | Chuck Finley | Mark Williamson | Bryan Harvey | 128 | 162 | -34 |
| 1991-05-19 | vs CAL | 34 | L 2-10 | 12-22 | 7 | 36,225 | Jeff Ballard | Kirk McCaskill | Kirk McCaskill | Jeff Ballard | | 130 | 172 | -42 |
| 1991-05-20 | @ DET | 35 | L 5-11 | 12-23 | 7 | 22,231 | Bob Milacki | Walt Terrell | Jerry Gleaton | Bob Milacki | | 135 | 183 | -48 |
| 1991-05-21 | @ DET | 36 | W 5-4 | 13-23 | 6 | 11,339 | Jose Mesa | John Cerutti | Mike Flanagan | Paul Gibson | Gregg Olson | 140 | 187 | -47 |
| 1991-05-22 | @ DET | 37 | L 5-9 | 13-24 | 7 | 13,440 | Ben McDonald | Bill Gullickson | Bill Gullickson | Ben McDonald | | 145 | 196 | -51 |
| 1991-05-24 | vs NYA | 38 | L 1-7 | 13-25 | 7 | 30,436 | Jeff Robinson | Scott Sanderson | Scott Sanderson | Jeff Robinson | | 146 | 203 | -57 |
| 1991-05-25 | vs NYA | 39 | L 5-6 | 13-26 | 7 | 36,459 | Jeff Ballard | Pascual Perez | Steve Farr | Mike Flanagan | Lee Guetterman | 151 | 209 | -58 |
| 1991-05-26 | vs NYA | 40 | L 1-2 | 13-27 | 7 | 39,259 | Jose Mesa | Chuck Cary | John Habyan | Mike Flanagan | Greg Cadaret | 152 | 211 | -59 |
| 1991-05-27 | vs CLE | 41 | L 2-3 | 13-28 | 7 | 23,338 | Bob Milacki | Tom Candiotti | Tom Candiotti | Bob Milacki | Shawn Hillegas | 154 | 214 | -60 |
| 1991-05-28 | vs CLE | 42 | W 5-2 | 14-28 | 7 | 19,349 | Roy Smith | Charles Nagy | Roy Smith | Charles Nagy | Gregg Olson | 159 | 216 | -57 |
| 1991-05-29 | vs CLE | 43 | W 2-1 | 15-28 | 7 | 23,328 | Jeff Robinson | Rod Nichols | Jeff Robinson | Mike Walker | Gregg Olson | 161 | 217 | -56 |
| 1991-05-30 | @ BOS | 44 | W 9-3 | 16-28 | 7 | 33,795 | Jeff Ballard | Matt Young | Jeff Ballard | Matt Young | Mike Flanagan | 170 | 220 | -50 |
| 1991-05-31 | @ BOS | 45 | L 2-7 | 16-29 | 7 | 33,744 | Jose Mesa | Mike Gardiner | Mike Gardiner | Jose Mesa | | 172 | 227 | -55 |
| 1991-06-01 | @ BOS | 46 | W 3-1 | 17-29 | 7 | 33,648 | Bob Milacki | Danny Darwin | Kevin Hickey | Danny Darwin | Gregg Olson | 175 | 228 | -53 |
| 1991-06-02 | @ BOS | 47 | W 5-1 | 18-29 | 7 | 34,305 | Roy Smith | Roger Clemens | Roy Smith | Roger Clemens | Mark Williamson | 180 | 229 | -49 |
| 1991-06-03 | @ MIN | 48 | L 2-3 | 18-30 | 7 | 12,497 | Jeff Robinson | Jack Morris | Jack Morris | Jeff Robinson | Rick Aguilera | 182 | 232 | -50 |
| 1991-06-04 | @ MIN | 49 | L 3-4 | 18-31 | 7 | 11,672 | Jeff Ballard | Mark Guthrie | Carl Willis | Gregg Olson | | 185 | 236 | -51 |
| 1991-06-05 | @ MIN | 50 | L 3-4 | 18-32 | 7 | 12,464 | Jose Mesa | Kevin Tapani | Kevin Tapani | Jose Mesa | Rick Aguilera | 188 | 240 | -52 |
| 1991-06-06 | vs TOR | 51 | W 6-4 | 19-32 | 7 | 26,539 | Bob Milacki | Jim Acker | Bob Milacki | Mike Timlin | Gregg Olson | 194 | 244 | -50 |
| 1991-06-07 | vs TOR | 52 | W 6-4 | 20-32 | 7 | 38,228 | Roy Smith | Juan Guzman | Roy Smith | Juan Guzman | Gregg Olson | 200 | 248 | -48 |
| 1991-06-08 | vs TOR | 53 | L 4-8 | 20-33 | 7 | 45,569 | Jeff Robinson | Jimmy Key | Jimmy Key | Paul Kilgus | | 204 | 256 | -52 |
| 1991-06-09 | vs TOR | 54 | L 2-3 | 20-34 | 7 | 27,783 | Jeff Ballard | Todd Stottlemyre | Todd Stottlemyre | Jeff Ballard | Tom Henke | 206 | 259 | -53 |
| 1991-06-11 | vs KCA | 55 | L 0-11 | 20-35 | 7 | 29,472 | Jose Mesa | Mark Gubicza | Mark Gubicza | Jose Mesa | Steve Crawford | 206 | 270 | -64 |
| 1991-06-12 | vs KCA | 56 | L 8-9 | 20-36 | 7 | 22,758 | Bob Milacki | Bret Saberhagen | Mark Davis | Mark Williamson | Jeff Montgomery | 214 | 279 | -65 |
| 1991-06-13 | vs KCA | 57 | L 4-6 | 20-37 | 7 | 27,012 | Roy Smith | Kevin Appier | Mark Davis | Paul Kilgus | Jeff Montgomery | 218 | 285 | -67 |
| 1991-06-14 | @ TOR | 58 | L 1-9 | 20-38 | 7 | 50,287 | Jeff Robinson | Todd Stottlemyre | Todd Stottlemyre | Jeff Robinson | | 219 | 294 | -75 |
| 1991-06-15 | @ TOR | 59 | W 8-4 | 21-38 | 7 | 50,292 | Jeff Ballard | Juan Guzman | Jeff Ballard | Juan Guzman | Mark Williamson | 227 | 298 | -71 |
| 1991-06-16 | @ TOR | 60 | W 13-8 | 22-38 | 6 | 50,273 | Jose Mesa | David Wells | Todd Frohwirth | Duane Ward | | 240 | 306 | -66 |
| 1991-06-17 | vs MIN | 61 | W 6-5 | 23-38 | 6 | 25,600 | Bob Milacki | Allan Anderson | Mark Williamson | Rick Aguilera | | 246 | 311 | -65 |
| 1991-06-18 | vs MIN | 62 | L 2-9 | 23-39 | 6 | 26,401 | Roy Smith | Scott Erickson | Scott Erickson | Roy Smith | Carl Willis | 248 | 320 | -72 |
| 1991-06-19 | vs MIN | 63 | L 4-8 | 23-40 | 7 | 44,742 | Jeff Robinson | Jack Morris | Jack Morris | Gregg Olson | | 252 | 328 | -76 |
| 1991-06-20 | @ KCA | 64 | L 2-3 | 23-41 | 7 | 35,520 | Jeff Ballard | Mike Boddicker | Steve Crawford | Todd Frohwirth | | 254 | 331 | -77 |
| 1991-06-22 | @ KCA | 65 | W 1-0 | 24-41 | 6 | 36,141 | Bob Milacki | Tom Gordon | Bob Milacki | Tom Gordon | Gregg Olson | 255 | 331 | -76 |
| 1991-06-23 | @ KCA | 66 | W 11-8 | 26-41 | 6 | 0 | Roy Smith | Kevin Appier | Todd Frohwirth | Jeff Montgomery | Gregg Olson | 266 | 339 | -73 |
| 1991-06-23 | @ KCA | 67 | W 9-8 | 26-41 | 6 | 30,018 | Jose Mesa | Luis Aquino | Gregg Olson | Storm Davis | Paul Kilgus | 275 | 347 | -72 |
| 1991-06-25 | @ CLE | 68 | W 5-3 | 27-41 | 6 | 11,150 | Jeff Robinson | Rod Nichols | Mark Williamson | Doug Jones | Gregg Olson | 280 | 350 | -70 |
| 1991-06-26 | @ CLE | 69 | L 4-10 | 27-42 | 6 | 10,457 | Jeff Ballard | Greg Swindell | Greg Swindell | Jeff Ballard | Jeff Shaw | 284 | 360 | -76 |
| 1991-06-27 | @ CLE | 70 | W 7-2 | 28-42 | 6 | 18,889 | Bob Milacki | Jeff Mutis | Bob Milacki | Jeff Mutis | Gregg Olson | 291 | 362 | -71 |
| 1991-06-28 | vs BOS | 71 | L 3-9 | 28-43 | 6 | 48,327 | Jose Mesa | Greg Harris | Greg Harris | Jose Mesa | | 294 | 371 | -77 |
| 1991-06-29 | vs BOS | 72 | W 7-3 | 29-43 | 6 | 44,023 | Roy Smith | Danny Darwin | Roy Smith | Danny Darwin | | 301 | 374 | -73 |
| 1991-06-30 | vs BOS | 73 | W 6-4 | 30-43 | 6 | 47,274 | Jeff Robinson | Joe Hesketh | Mark Williamson | Joe Hesketh | Gregg Olson | 307 | 378 | -71 |
| 1991-07-01 | vs DET | 74 | W 10-2 | 31-43 | 6 | 28,835 | Ben McDonald | Dan Gakeler | Ben McDonald | Dan Gakeler | | 317 | 380 | -63 |
| 1991-07-02 | vs DET | 75 | L 3-4 | 31-44 | 6 | 30,898 | Jeff Ballard | Bill Gullickson | Bill Gullickson | Jeff Ballard | Mike Henneman | 320 | 384 | -64 |
| 1991-07-03 | vs DET | 76 | L 2-8 | 31-45 | 6 | 46,702 | Bob Milacki | Frank Tanana | Frank Tanana | Bob Milacki | | 322 | 392 | -70 |
| 1991-07-04 | @ NYA | 77 | L 2-3 | 31-46 | 6 | 31,309 | Roy Smith | Jeff Johnson | Eric Plunk | Roy Smith | Lee Guetterman | 324 | 395 | -71 |
| 1991-07-05 | @ NYA | 78 | W 7-4 | 32-46 | 6 | 21,123 | Jeff Robinson | Tim Leary | Jeff Robinson | Tim Leary | Gregg Olson | 331 | 399 | -68 |
| 1991-07-06 | @ NYA | 79 | L 5-13 | 32-47 | 6 | 29,932 | Ben McDonald | Scott Sanderson | Eric Plunk | Todd Frohwirth | | 336 | 412 | -76 |
| 1991-07-07 | @ NYA | 80 | W 5-3 | 33-47 | 6 | 43,505 | Jeff Ballard | Wade Taylor | Jeff Ballard | Wade Taylor | Gregg Olson | 341 | 415 | -74 |
| 1991-07-11 | @ OAK | 81 | L 1-8 | 33-48 | 6 | 34,015 | Jeff Robinson | Dave Stewart | Dave Stewart | Jeff Robinson | | 342 | 423 | -81 |
| 1991-07-12 | @ OAK | 82 | W 6-3 | 34-48 | 6 | 36,539 | Ben McDonald | Bob Welch | Ben McDonald | Curt Young | Gregg Olson | 348 | 426 | -78 |
| 1991-07-13 | @ OAK | 83 | W 2-0 | 35-48 | 6 | 40,047 | Bob Milacki | Eric Show | Bob Milacki | Eric Show | Gregg Olson | 350 | 426 | -76 |
| 1991-07-14 | @ OAK | 84 | L 2-3 | 35-49 | 6 | 31,425 | Roy Smith | Mike Moore | Todd Burns | Gregg Olson | | 352 | 429 | -77 |
| 1991-07-15 | @ CAL | 85 | W 2-1 | 36-49 | 6 | 22,896 | Jeff Ballard | Kirk McCaskill | Jeff Ballard | Bryan Harvey | Todd Frohwirth | 354 | 430 | -76 |
| 1991-07-16 | @ CAL | 86 | L 1-2 | 36-50 | 6 | 26,062 | Jeff Robinson | Mark Langston | Mark Langston | Jeff Robinson | | 355 | 432 | -77 |
| 1991-07-17 | @ KCA | 87 | L 8-9 | 36-51 | 6 | 21,821 | Ben McDonald | Mark Gubicza | Luis Aquino | Mark Williamson | | 363 | 441 | -78 |
| 1991-07-18 | @ KCA | 88 | L 1-5 | 36-52 | 6 | 30,170 | Bob Milacki | Bret Saberhagen | Bret Saberhagen | Bob Milacki | | 364 | 446 | -82 |
| 1991-07-19 | vs SEA | 89 | W 4-1 | 37-52 | 6 | 39,384 | Roy Smith | Rich DeLucia | Roy Smith | Rich DeLucia | Gregg Olson | 368 | 447 | -79 |
| 1991-07-20 | vs SEA | 90 | L 1-5 | 37-53 | 6 | 35,535 | Jeff Ballard | Bill Krueger | Bill Krueger | Jeff Ballard | | 369 | 452 | -83 |
| 1991-07-21 | vs SEA | 91 | L 4-6 | 37-54 | 6 | 32,901 | Jeff Robinson | Brian Holman | Russ Swan | Jeff Robinson | Bill Swift | 373 | 458 | -85 |
| 1991-07-23 | vs CAL | 92 | L 4-5 | 37-55 | 6 | 25,537 | Ben McDonald | Jim Abbott | Jim Abbott | Ben McDonald | Bryan Harvey | 377 | 463 | -86 |
| 1991-07-24 | vs CAL | 93 | W 5-2 | 38-55 | 6 | 27,390 | Bob Milacki | Chuck Finley | Bob Milacki | Chuck Finley | Gregg Olson | 382 | 465 | -83 |
| 1991-07-25 | vs CAL | 94 | W 8-4 | 39-55 | 6 | 37,444 | Roy Smith | Kirk McCaskill | Todd Frohwirth | Kirk McCaskill | | 390 | 469 | -79 |
| 1991-07-26 | vs OAK | 95 | L 9-12 | 39-56 | 6 | 43,207 | Jeff Robinson | Dave Stewart | Joe Klink | Mark Williamson | Steve Chitren | 399 | 481 | -82 |
| 1991-07-27 | vs OAK | 96 | L 1-9 | 39-57 | 6 | 50,071 | Jeff Ballard | Joe Slusarski | Joe Slusarski | Jeff Ballard | | 400 | 490 | -90 |
| 1991-07-28 | vs OAK | 97 | L 3-4 | 39-58 | 6 | 48,341 | Ben McDonald | Bob Welch | Rick Honeycutt | Ben McDonald | Dennis Eckersley | 403 | 494 | -91 |
| 1991-07-29 | @ SEA | 98 | L 4-11 | 39-59 | 6 | 31,910 | Bob Milacki | Erik Hanson | Erik Hanson | Bob Milacki | | 407 | 505 | -98 |
| 1991-07-30 | @ SEA | 99 | L 2-8 | 39-60 | 6 | 18,725 | Roy Smith | Bill Krueger | Bill Krueger | Roy Smith | | 409 | 513 | -104 |
| 1991-07-31 | @ SEA | 100 | W 4-2 | 40-60 | 6 | 22,503 | Dave Johnson | Rich DeLucia | Mike Flanagan | Bill Swift | Gregg Olson | 413 | 515 | -102 |
| 1991-08-02 | @ CHA | 101 | W 3-0 | 41-60 | 6 | 40,437 | Ben McDonald | Alex Fernandez | Ben McDonald | Alex Fernandez | Gregg Olson | 416 | 515 | -99 |
| 1991-08-03 | @ CHA | 102 | W 6-3 | 42-60 | 6 | 41,169 | Bob Milacki | Jack McDowell | Bob Milacki | Jack McDowell | Gregg Olson | 422 | 518 | -96 |
| 1991-08-04 | @ CHA | 103 | L 0-1 | 42-61 | 6 | 41,059 | Mike Mussina | Charlie Hough | Charlie Hough | Mike Mussina | | 422 | 519 | -97 |
| 1991-08-05 | vs MIL | 104 | L 5-6 | 42-62 | 6 | 25,824 | Roy Smith | Don August | Doug Henry | Mark Williamson | Ed Nunez | 427 | 525 | -98 |
| 1991-08-06 | vs MIL | 105 | W 13-5 | 43-62 | 6 | 25,883 | Dave Johnson | Jim Hunter | Dave Johnson | Jim Hunter | | 440 | 530 | -90 |
| 1991-08-07 | vs MIL | 106 | L 2-4 | 43-63 | 6 | 24,239 | Ben McDonald | Jaime Navarro | Jaime Navarro | Ben McDonald | | 442 | 534 | -92 |
| 1991-08-08 | vs MIL | 107 | L 4-6 | 43-64 | 6 | 27,079 | Bob Milacki | Bill Wegman | Bill Wegman | Bob Milacki | Ed Nunez | 446 | 540 | -94 |
| 1991-08-09 | vs CHA | 108 | L 4-7 | 43-65 | 6 | 35,038 | Mike Mussina | Charlie Hough | Brian Drahman | Mike Mussina | Bobby Thigpen | 450 | 547 | -97 |
| 1991-08-10 | vs CHA | 109 | L 4-6 | 43-66 | 6 | 39,494 | Roy Smith | Ramon Garcia | Ramon Garcia | Mike Flanagan | Bobby Thigpen | 454 | 553 | -99 |
| 1991-08-11 | vs CHA | 110 | L 0-7 | 43-67 | 6 | 40,455 | Dave Johnson | Wilson Alvarez | Wilson Alvarez | Dave Johnson | | 454 | 560 | -106 |
| 1991-08-12 | vs CHA | 111 | W 5-4 | 44-67 | 6 | 25,975 | Ben McDonald | Jack McDowell | Gregg Olson | Donn Pall | | 459 | 564 | -105 |
| 1991-08-13 | vs TEX | 112 | W 4-3 | 46-67 | 6 | 0 | Bob Milacki | Brian Bohanon | Dave Johnson | Kenny Rogers | | 463 | 567 | -104 |
| 1991-08-13 | vs TEX | 113 | W 8-7 | 46-67 | 6 | 32,241 | Stacy Jones | Jose Guzman | Todd Frohwirth | Jose Guzman | Gregg Olson | 471 | 574 | -103 |
| 1991-08-14 | vs TEX | 114 | W 10-2 | 47-67 | 6 | 32,231 | Mike Mussina | Gerald Alexander | Mike Mussina | Gerald Alexander | | 481 | 576 | -95 |
| 1991-08-15 | vs TEX | 115 | W 9-2 | 48-67 | 6 | 32,557 | Jose Mesa | Oil Can Boyd | Jose Mesa | Oil Can Boyd | | 490 | 578 | -88 |
| 1991-08-16 | @ MIL | 116 | L 5-8 | 48-68 | 6 | 18,050 | Dave Johnson | Don August | Don August | Roy Smith | | 495 | 586 | -91 |
| 1991-08-17 | @ MIL | 117 | L 6-7 | 48-69 | 6 | 31,063 | Ben McDonald | Jaime Navarro | Jaime Navarro | Ben McDonald | Ed Nunez | 501 | 593 | -92 |
| 1991-08-18 | @ MIL | 118 | L 1-2 | 48-70 | 6 | 22,638 | Bob Milacki | Bill Wegman | Bill Wegman | Bob Milacki | Doug Henry | 502 | 595 | -93 |
| 1991-08-19 | @ TEX | 119 | L 1-4 | 48-71 | 6 | 33,652 | Mike Mussina | Nolan Ryan | Nolan Ryan | Mike Mussina | Terry Mathews | 503 | 599 | -96 |
| 1991-08-20 | @ TEX | 120 | W 8-6 | 49-71 | 6 | 19,393 | Jose Mesa | Oil Can Boyd | Dave Johnson | Wayne Rosenthal | Mike Flanagan | 511 | 605 | -94 |
| 1991-08-21 | @ TEX | 121 | W 4-3 | 50-71 | 6 | 18,576 | Arthur Rhodes | Kevin Brown | Todd Frohwirth | Kevin Brown | Gregg Olson | 515 | 608 | -93 |
| 1991-08-23 | vs MIN | 122 | W 5-4 | 51-71 | 6 | 35,365 | Ben McDonald | Allan Anderson | Gregg Olson | Carl Willis | | 520 | 612 | -92 |
| 1991-08-24 | vs MIN | 123 | L 2-5 | 51-72 | 6 | 37,958 | Bob Milacki | Tom Edens | Steve Bedrosian | Mike Flanagan | Rick Aguilera | 522 | 617 | -95 |
| 1991-08-25 | vs MIN | 124 | W 7-3 | 52-72 | 6 | 36,202 | Mike Mussina | Scott Erickson | Mike Mussina | Scott Erickson | Todd Frohwirth | 529 | 620 | -91 |
| 1991-08-26 | vs TOR | 125 | L 2-5 | 52-73 | 6 | 28,063 | Dave Johnson | Jimmy Key | Jimmy Key | Dave Johnson | Tom Henke | 531 | 625 | -94 |
| 1991-08-27 | vs TOR | 126 | L 1-6 | 52-74 | 6 | 25,090 | Arthur Rhodes | Juan Guzman | Juan Guzman | Arthur Rhodes | | 532 | 631 | -99 |
| 1991-08-28 | vs TOR | 127 | L 0-3 | 52-75 | 6 | 28,262 | Ben McDonald | Tom Candiotti | Tom Candiotti | Ben McDonald | Tom Henke | 532 | 634 | -102 |
| 1991-08-30 | @ MIN | 128 | W 11-5 | 53-75 | 6 | 30,214 | Bob Milacki | Tom Edens | Bob Milacki | Tom Edens | | 543 | 639 | -96 |
| 1991-08-31 | @ MIN | 129 | L 2-5 | 53-76 | 6 | 38,395 | Mike Mussina | Kevin Tapani | Kevin Tapani | Mike Mussina | Rick Aguilera | 545 | 644 | -99 |
| 1991-09-01 | @ MIN | 130 | L 3-14 | 53-77 | 6 | 31,435 | Arthur Rhodes | Jack Morris | Jack Morris | Arthur Rhodes | | 548 | 658 | -110 |
| 1991-09-02 | @ TOR | 131 | L 4-5 | 53-78 | 6 | 50,314 | Dave Johnson | Tom Candiotti | Mike Timlin | Gregg Olson | | 552 | 663 | -111 |
| 1991-09-03 | @ TOR | 132 | W 8-4 | 54-78 | 6 | 50,299 | Ben McDonald | David Wells | Ben McDonald | David Wells | Mike Flanagan | 560 | 667 | -107 |
| 1991-09-04 | @ TOR | 133 | L 1-3 | 54-79 | 6 | 50,303 | Bob Milacki | Todd Stottlemyre | Todd Stottlemyre | Bob Milacki | Duane Ward | 561 | 670 | -109 |
| 1991-09-06 | vs KCA | 134 | W 6-2 | 55-79 | 6 | 26,372 | Mike Mussina | Bret Saberhagen | Jim Poole | Bret Saberhagen | | 567 | 672 | -105 |
| 1991-09-07 | vs KCA | 135 | L 4-7 | 55-80 | 6 | 32,409 | Jose Mesa | Luis Aquino | Luis Aquino | Jose Mesa | | 571 | 679 | -108 |
| 1991-09-08 | vs KCA | 136 | L 2-3 | 55-81 | 6 | 32,488 | Ben McDonald | Kevin Appier | Joel Johnston | Todd Frohwirth | Jeff Montgomery | 573 | 682 | -109 |
| 1991-09-09 | vs NYA | 137 | W 8-0 | 56-81 | 6 | 22,792 | Bob Milacki | Scott Sanderson | Bob Milacki | Scott Sanderson | | 581 | 682 | -101 |
| 1991-09-10 | vs NYA | 138 | W 6-3 | 57-81 | 6 | 22,551 | Arthur Rhodes | Eric Plunk | Todd Frohwirth | Eric Plunk | | 587 | 685 | -98 |
| 1991-09-11 | vs NYA | 139 | W 4-2 | 58-81 | 6 | 44,847 | Mike Mussina | Wade Taylor | Mike Mussina | Wade Taylor | Gregg Olson | 591 | 687 | -96 |
| 1991-09-12 | vs CLE | 140 | L 5-6 | 58-82 | 6 | 20,401 | Jose Mesa | Charles Nagy | Charles Nagy | Jose Mesa | Steve Olin | 596 | 693 | -97 |
| 1991-09-13 | vs CLE | 141 | W 5-4 | 59-82 | 6 | 30,861 | Anthony Telford | Dave Otto | Gregg Olson | Jeff Shaw | | 601 | 697 | -96 |
| 1991-09-14 | vs CLE | 142 | L 5-6 | 59-83 | 6 | 31,575 | Bob Milacki | Greg Swindell | Eric Bell | Mike Flanagan | Steve Olin | 606 | 703 | -97 |
| 1991-09-15 | vs CLE | 143 | W 4-3 | 60-83 | 6 | 35,326 | Arthur Rhodes | Eric King | Mark Williamson | Willie Blair | Gregg Olson | 610 | 706 | -96 |
| 1991-09-16 | @ BOS | 144 | W 9-2 | 61-83 | 6 | 31,977 | Mike Mussina | Tom Bolton | Mike Mussina | Tom Bolton | | 619 | 708 | -89 |
| 1991-09-17 | @ BOS | 145 | L 3-4 | 61-84 | 6 | 32,657 | Jose Mesa | Kevin Morton | Kevin Morton | Jose Mesa | Jeff Reardon | 622 | 712 | -90 |
| 1991-09-18 | @ BOS | 146 | L 5-7 | 61-85 | 6 | 32,021 | Dave Johnson | Mike Gardiner | Mike Gardiner | Dave Johnson | Greg Harris | 627 | 719 | -92 |
| 1991-09-20 | @ CLE | 147 | W 2-1 | 62-85 | 6 | 5,057 | Bob Milacki | Dave Otto | Bob Milacki | Dave Otto | Gregg Olson | 629 | 720 | -91 |
| 1991-09-21 | @ CLE | 148 | L 1-10 | 62-86 | 6 | 6,957 | Arthur Rhodes | Greg Swindell | Greg Swindell | Arthur Rhodes | | 630 | 730 | -100 |
| 1991-09-22 | @ CLE | 149 | L 1-2 | 62-87 | 6 | 6,863 | Mike Mussina | Shawn Hillegas | Eric Bell | Mike Mussina | | 631 | 732 | -101 |
| 1991-09-23 | vs BOS | 150 | W 4-3 | 63-87 | 6 | 27,349 | Jose Mesa | Mike Gardiner | Jim Poole | Mike Gardiner | Gregg Olson | 635 | 735 | -100 |
| 1991-09-26 | vs BOS | 151 | L 1-2 | 64-88 | 6 | 0 | Dave Johnson | Roger Clemens | Roger Clemens | Dave Johnson | | 636 | 737 | -101 |
| 1991-09-26 | vs BOS | 152 | W 6-5 | 64-88 | 6 | 10,728 | Bob Milacki | Joe Hesketh | Todd Frohwirth | Greg Harris | | 642 | 742 | -100 |
| 1991-09-27 | @ DET | 153 | W 9-7 | 65-88 | 6 | 13,449 | Arthur Rhodes | Walt Terrell | Mark Williamson | Walt Terrell | Gregg Olson | 651 | 749 | -98 |
| 1991-09-28 | @ DET | 154 | L 4-5 | 65-89 | 6 | 22,541 | Mike Mussina | Bill Gullickson | Mike Henneman | Gregg Olson | | 655 | 754 | -99 |
| 1991-09-29 | @ DET | 155 | W 7-4 | 66-89 | 5 | 17,925 | Jose Mesa | Scott Aldred | Jose Mesa | Scott Aldred | Todd Frohwirth | 662 | 758 | -96 |
| 1991-09-30 | @ DET | 156 | L 3-8 | 66-90 | 6 | 11,824 | Dave Johnson | Mark Leiter | Mark Leiter | Dave Johnson | | 665 | 766 | -101 |
| 1991-10-01 | @ NYA | 157 | L 2-3 | 66-91 | 6 | 12,991 | Bob Milacki | Dave Eiland | Rich Monteleone | Jim Poole | | 667 | 769 | -102 |
| 1991-10-02 | @ NYA | 158 | L 3-4 | 66-92 | 6 | 12,088 | Arthur Rhodes | Pascual Perez | Greg Cadaret | Mike Flanagan | Steve Farr | 670 | 773 | -103 |
| 1991-10-03 | @ NYA | 159 | L 6-9 | 66-93 | 6 | 12,772 | Jeff Ballard | Jeff Johnson | Jeff Johnson | Jeff Ballard | Steve Farr | 676 | 782 | -106 |
| 1991-10-04 | vs DET | 160 | L 2-4 | 66-94 | 6 | 47,983 | Mike Mussina | Scott Aldred | Dave Haas | Jim Poole | John Cerutti | 678 | 786 | -108 |
| 1991-10-05 | vs DET | 161 | W 7-3 | 67-94 | 6 | 49,289 | Dave Johnson | Mark Leiter | Jim Poole | Mark Leiter | Mark Williamson | 685 | 789 | -104 |
| 1991-10-06 | vs DET | 162 | L 1-7 | 67-95 | 6 | 50,700 | Bob Milacki | Frank Tanana | Frank Tanana | Bob Milacki | | 686 | 796 | -110 |