| 1991-04-09 | vs SFN | 1 | W 7-4 | 1-0 | 2 | 48,089 | Ed Whitson | John Burkett | Mike Maddux | Trevor Wilson | Larry Andersen | 7 | 4 | 3 |
| 1991-04-10 | vs SFN | 2 | W 4-3 | 2-0 | 3 | 18,590 | Bruce Hurst | Buddy Black | Bruce Hurst | Buddy Black | Craig Lefferts | 11 | 7 | 4 |
| 1991-04-11 | vs SFN | 3 | L 9-11 | 2-1 | 3 | 22,475 | Andy Benes | Mike LaCoss | Dave Righetti | Craig Lefferts | | 20 | 18 | 2 |
| 1991-04-12 | @ LAN | 4 | W 4-2 | 3-1 | 1 | 49,676 | Greg Harris | Bob Ojeda | Greg Harris | Bob Ojeda | Wes Gardner | 24 | 20 | 4 |
| 1991-04-13 | @ LAN | 5 | W 6-3 | 4-1 | 1 | 47,793 | Eric Nolte | Kevin Gross | Eric Nolte | Kevin Gross | Mike Maddux | 30 | 23 | 7 |
| 1991-04-14 | @ LAN | 6 | W 5-3 | 5-1 | 1 | 47,698 | Ed Whitson | Mike Morgan | Ed Whitson | Mike Morgan | Craig Lefferts | 35 | 26 | 9 |
| 1991-04-15 | vs CIN | 7 | W 3-2 | 6-1 | 1 | 18,815 | Bruce Hurst | Jose Rijo | Mike Maddux | Ted Power | | 38 | 28 | 10 |
| 1991-04-16 | vs CIN | 8 | L 0-1 | 6-2 | 1 | 19,752 | Andy Benes | Norm Charlton | Norm Charlton | Andy Benes | Randy Myers | 38 | 29 | 9 |
| 1991-04-17 | vs CIN | 9 | L 1-5 | 6-3 | 1 | 18,014 | Greg Harris | Chris Hammond | Chris Hammond | Greg Harris | Scott Scudder | 39 | 34 | 5 |
| 1991-04-18 | vs LAN | 10 | W 10-5 | 7-3 | 1 | 26,331 | Eric Nolte | Kevin Gross | Eric Nolte | Kevin Gross | | 49 | 39 | 10 |
| 1991-04-19 | vs LAN | 11 | L 0-4 | 7-4 | 1 | 30,795 | Ed Whitson | Mike Morgan | Mike Morgan | Ed Whitson | | 49 | 43 | 6 |
| 1991-04-20 | vs LAN | 12 | W 5-3 | 8-4 | 1 | 39,335 | Bruce Hurst | Tim Belcher | Larry Andersen | Tim Belcher | Craig Lefferts | 54 | 46 | 8 |
| 1991-04-21 | vs LAN | 13 | L 0-6 | 8-5 | 1 | 36,269 | Andy Benes | Ramon Martinez | Ramon Martinez | Andy Benes | | 54 | 52 | 2 |
| 1991-04-22 | @ SFN | 14 | W 7-5 | 9-5 | 1 | 12,156 | Greg Harris | Kelly Downs | Pat Clements | Trevor Wilson | Craig Lefferts | 61 | 57 | 4 |
| 1991-04-23 | @ SFN | 15 | W 7-6 | 10-5 | 1 | 12,436 | Eric Nolte | Scott Garrelts | Eric Nolte | Scott Garrelts | Craig Lefferts | 68 | 63 | 5 |
| 1991-04-24 | @ SFN | 16 | L 1-6 | 10-6 | 1 | 11,491 | Ed Whitson | John Burkett | John Burkett | Ed Whitson | | 69 | 69 | 0 |
| 1991-04-26 | @ PHI | 17 | W 4-0 | 11-6 | 1 | 19,363 | Bruce Hurst | Jose De Jesus | Bruce Hurst | Jose De Jesus | | 73 | 69 | 4 |
| 1991-04-27 | @ PHI | 18 | L 3-4 | 11-7 | 1 | 20,334 | Andy Benes | Danny Cox | Darrel Akerfelds | Mike Maddux | | 76 | 73 | 3 |
| 1991-04-28 | @ PHI | 19 | L 2-9 | 11-8 | 1 | 39,332 | Eric Nolte | Jason Grimsley | Jason Grimsley | Eric Nolte | | 78 | 82 | -4 |
| 1991-04-29 | @ PHI | 20 | L 2-7 | 11-9 | 2 | 12,359 | Ed Whitson | Terry Mulholland | Terry Mulholland | Ed Whitson | | 80 | 89 | -9 |
| 1991-04-30 | @ NYN | 21 | L 3-6 | 11-10 | 2 | 17,059 | Derek Lilliquist | Dwight Gooden | Dwight Gooden | Derek Lilliquist | Alejandro Pena | 83 | 95 | -12 |
| 1991-05-01 | @ NYN | 22 | W 8-7 | 12-10 | 2 | 19,952 | Bruce Hurst | Frank Viola | Bruce Hurst | Frank Viola | Craig Lefferts | 91 | 102 | -11 |
| 1991-05-03 | @ MON | 23 | L 1-4 | 12-11 | 2 | 12,221 | Andy Benes | Oil Can Boyd | Oil Can Boyd | Andy Benes | | 92 | 106 | -14 |
| 1991-05-04 | @ MON | 24 | W 6-5 | 13-11 | 2 | 12,374 | Eric Nolte | Rick Mahler | Rich Rodriguez | Jeff Fassero | | 98 | 111 | -13 |
| 1991-05-05 | @ MON | 25 | W 6-3 | 14-11 | 2 | 15,397 | Ed Whitson | Brian Barnes | Ed Whitson | Brian Barnes | | 104 | 114 | -10 |
| 1991-05-07 | vs PHI | 26 | W 4-2 | 15-11 | 1 | 23,172 | Bruce Hurst | Jose De Jesus | Bruce Hurst | Jose De Jesus | Craig Lefferts | 108 | 116 | -8 |
| 1991-05-08 | vs PHI | 27 | L 2-5 | 15-12 | 1 | 12,063 | Andy Benes | Danny Cox | Danny Cox | Andy Benes | Roger McDowell | 110 | 121 | -11 |
| 1991-05-09 | vs PHI | 28 | L 6-9 | 15-13 | 2 | 43,153 | Derek Lilliquist | Terry Mulholland | Terry Mulholland | Derek Lilliquist | Mitch Williams | 116 | 130 | -14 |
| 1991-05-10 | vs MON | 29 | L 4-6 | 15-14 | 3 | 54,841 | Ed Whitson | Brian Barnes | Tim Burke | Wes Gardner | | 120 | 136 | -16 |
| 1991-05-11 | vs MON | 30 | L 1-5 | 15-15 | 4 | 24,062 | Adam Peterson | Dennis Martinez | Dennis Martinez | Adam Peterson | | 121 | 141 | -20 |
| 1991-05-12 | vs MON | 31 | L 6-8 | 15-16 | 4 | 17,202 | Bruce Hurst | Chris Nabholz | Bill Sampen | Rich Rodriguez | Barry Jones | 127 | 149 | -22 |
| 1991-05-13 | vs NYN | 32 | W 5-2 | 16-16 | 4 | 14,158 | Andy Benes | David Cone | Andy Benes | David Cone | Craig Lefferts | 132 | 151 | -19 |
| 1991-05-14 | vs NYN | 33 | L 1-6 | 16-17 | 4 | 24,389 | Eric Nolte | Wally Whitehurst | Wally Whitehurst | Eric Nolte | Pete Schourek | 133 | 157 | -24 |
| 1991-05-15 | vs NYN | 34 | L 1-7 | 16-18 | 4 | 24,858 | Ed Whitson | Dwight Gooden | Dwight Gooden | Ed Whitson | | 134 | 164 | -30 |
| 1991-05-17 | @ CIN | 35 | L 3-7 | 16-19 | 4 | 30,119 | Bruce Hurst | Jose Rijo | Randy Myers | Bruce Hurst | Rob Dibble | 137 | 171 | -34 |
| 1991-05-18 | @ CIN | 36 | W 5-2 | 17-19 | 4 | 38,495 | Adam Peterson | Jack Armstrong | Adam Peterson | Jack Armstrong | | 142 | 173 | -31 |
| 1991-05-19 | @ CIN | 37 | W 3-2 | 18-19 | 3 | 29,847 | Andy Benes | Norm Charlton | Andy Benes | Norm Charlton | Craig Lefferts | 145 | 175 | -30 |
| 1991-05-20 | @ ATL | 38 | W 7-3 | 19-19 | 3 | 7,800 | Ed Whitson | John Smoltz | Ed Whitson | John Smoltz | | 152 | 178 | -26 |
| 1991-05-21 | @ ATL | 39 | L 1-4 | 19-20 | 4 | 8,808 | Rich Rodriguez | Charlie Leibrandt | Kent Mercker | Steve Rosenberg | | 153 | 182 | -29 |
| 1991-05-22 | @ ATL | 40 | W 7-2 | 20-20 | 4 | 12,486 | Bruce Hurst | Steve Avery | Bruce Hurst | Steve Avery | | 160 | 184 | -24 |
| 1991-05-23 | @ ATL | 41 | W 11-10 | 21-20 | 4 | 13,780 | Adam Peterson | Pete Smith | Steve Rosenberg | Jeff Parrett | | 171 | 194 | -23 |
| 1991-05-24 | @ HOU | 42 | L 0-1 | 21-21 | 4 | 15,310 | Andy Benes | Pete Harnisch | Curt Schilling | Andy Benes | | 171 | 195 | -24 |
| 1991-05-25 | @ HOU | 43 | W 4-2 | 22-21 | 3 | 14,618 | Dennis Rasmussen | Jimmy Jones | Rich Rodriguez | Al Osuna | Craig Lefferts | 175 | 197 | -22 |
| 1991-05-26 | @ HOU | 44 | L 3-13 | 22-22 | 4 | 15,726 | Ed Whitson | Mark Portugal | Mark Portugal | Ed Whitson | | 178 | 210 | -32 |
| 1991-05-27 | vs ATL | 45 | L 1-3 | 22-23 | 4 | 21,342 | Bruce Hurst | Steve Avery | Steve Avery | Bruce Hurst | Juan Berenguer | 179 | 213 | -34 |
| 1991-05-28 | vs ATL | 46 | L 6-8 | 22-24 | 4 | 10,082 | Adam Peterson | Pete Smith | Mike Stanton | Craig Lefferts | Juan Berenguer | 185 | 221 | -36 |
| 1991-05-29 | vs ATL | 47 | L 1-5 | 22-25 | 4 | 13,038 | Andy Benes | Tom Glavine | Tom Glavine | Andy Benes | | 186 | 226 | -40 |
| 1991-05-30 | vs HOU | 48 | W 4-0 | 23-25 | 4 | 13,066 | Dennis Rasmussen | Jimmy Jones | Dennis Rasmussen | Jimmy Jones | | 190 | 226 | -36 |
| 1991-05-31 | vs HOU | 49 | W 5-4 | 24-25 | 4 | 17,749 | Jose Melendez | Mark Portugal | Jose Melendez | Mark Portugal | Craig Lefferts | 195 | 230 | -35 |
| 1991-06-01 | vs HOU | 50 | W 7-2 | 25-25 | 4 | 54,517 | Bruce Hurst | Jim Deshaies | Bruce Hurst | Jim Deshaies | | 202 | 232 | -30 |
| 1991-06-02 | vs HOU | 51 | W 3-1 | 26-25 | 3 | 16,239 | Adam Peterson | Xavier Hernandez | Adam Peterson | Xavier Hernandez | Craig Lefferts | 205 | 233 | -28 |
| 1991-06-04 | @ CHN | 52 | W 7-1 | 27-25 | 3 | 32,712 | Andy Benes | Bob Scanlan | Andy Benes | Bob Scanlan | | 212 | 234 | -22 |
| 1991-06-05 | @ CHN | 53 | W 3-0 | 28-25 | 3 | 22,500 | Dennis Rasmussen | Mike Bielecki | Dennis Rasmussen | Mike Bielecki | | 215 | 234 | -19 |
| 1991-06-06 | @ CHN | 54 | L 2-6 | 28-26 | 3 | 23,200 | Jose Melendez | Greg Maddux | Greg Maddux | Jose Melendez | | 217 | 240 | -23 |
| 1991-06-07 | @ PIT | 55 | L 0-1 | 28-27 | 3 | 25,095 | Bruce Hurst | Doug Drabek | Doug Drabek | Bruce Hurst | Bill Landrum | 217 | 241 | -24 |
| 1991-06-08 | @ PIT | 56 | W 11-0 | 29-27 | 3 | 51,292 | Mike Maddux | Randy Tomlin | Mike Maddux | Randy Tomlin | | 228 | 241 | -13 |
| 1991-06-09 | @ PIT | 57 | W 5-3 | 30-27 | 3 | 33,278 | Andy Benes | Zane Smith | Andy Benes | Zane Smith | Craig Lefferts | 233 | 244 | -11 |
| 1991-06-10 | @ PIT | 58 | L 3-5 | 30-28 | 3 | 10,512 | Dennis Rasmussen | Bob Walk | Vicente Palacios | Dennis Rasmussen | Bill Landrum | 236 | 249 | -13 |
| 1991-06-11 | vs SLN | 59 | L 4-10 | 30-29 | 4 | 24,383 | Jose Melendez | Ken Hill | Ken Hill | Jose Melendez | | 240 | 259 | -19 |
| 1991-06-12 | vs SLN | 60 | W 7-2 | 31-29 | 3 | 15,636 | Bruce Hurst | Omar Olivares | Bruce Hurst | Cris Carpenter | | 247 | 261 | -14 |
| 1991-06-13 | vs SLN | 61 | L 1-12 | 31-30 | 4 | 19,292 | Atlee Hammaker | Bob Tewksbury | Bob Tewksbury | Atlee Hammaker | | 248 | 273 | -25 |
| 1991-06-14 | vs CHN | 62 | L 3-7 | 31-31 | 4 | 30,161 | Andy Benes | Danny Jackson | Danny Jackson | Andy Benes | Dave Smith | 251 | 280 | -29 |
| 1991-06-15 | vs CHN | 63 | W 6-2 | 32-31 | 4 | 23,557 | Dennis Rasmussen | Les Lancaster | Dennis Rasmussen | Mike Bielecki | | 257 | 282 | -25 |
| 1991-06-16 | vs CHN | 64 | W 4-2 | 33-31 | 4 | 28,961 | Jose Melendez | Greg Maddux | Jose Melendez | Greg Maddux | Larry Andersen | 261 | 284 | -23 |
| 1991-06-17 | vs PIT | 65 | L 2-3 | 33-32 | 4 | 15,951 | Bruce Hurst | Doug Drabek | Doug Drabek | Bruce Hurst | Vicente Palacios | 263 | 287 | -24 |
| 1991-06-18 | vs PIT | 66 | L 1-3 | 33-33 | 4 | 14,697 | Adam Peterson | Randy Tomlin | Bill Landrum | Craig Lefferts | | 264 | 290 | -26 |
| 1991-06-19 | vs PIT | 67 | W 6-5 | 34-33 | 4 | 27,272 | Andy Benes | Zane Smith | Larry Andersen | Neal Heaton | | 270 | 295 | -25 |
| 1991-06-21 | @ SLN | 68 | L 3-4 | 34-34 | 4 | 40,927 | Dennis Rasmussen | Bryn Smith | Juan Agosto | Larry Andersen | | 273 | 299 | -26 |
| 1991-06-22 | @ SLN | 69 | W 4-3 | 35-34 | 4 | 41,808 | Jose Melendez | Ken Hill | Jose Melendez | Ken Hill | Craig Lefferts | 277 | 302 | -25 |
| 1991-06-23 | @ SLN | 70 | W 3-2 | 36-34 | 4 | 30,882 | Bruce Hurst | Omar Olivares | Bruce Hurst | Juan Agosto | | 280 | 304 | -24 |
| 1991-06-24 | @ SLN | 71 | W 4-1 | 37-34 | 3 | 32,096 | Adam Peterson | Bob Tewksbury | Adam Peterson | Bob Tewksbury | | 284 | 305 | -21 |
| 1991-06-25 | @ CIN | 72 | L 2-8 | 37-35 | 3 | 26,583 | Andy Benes | Chris Hammond | Chris Hammond | Andy Benes | | 286 | 313 | -27 |
| 1991-06-26 | @ CIN | 73 | L 2-6 | 37-36 | 4 | 30,119 | Dennis Rasmussen | Scott Scudder | Scott Scudder | Dennis Rasmussen | Randy Myers | 288 | 319 | -31 |
| 1991-06-27 | @ CIN | 74 | L 0-3 | 37-37 | 4 | 31,014 | Jose Melendez | Jack Armstrong | Jack Armstrong | Jose Melendez | Rob Dibble | 288 | 322 | -34 |
| 1991-06-28 | vs SFN | 75 | W 5-3 | 38-37 | 4 | 23,524 | Bruce Hurst | Don Robinson | Bruce Hurst | Don Robinson | Larry Andersen | 293 | 325 | -32 |
| 1991-06-29 | vs SFN | 76 | L 4-6 | 38-38 | 4 | 52,488 | Ed Whitson | Trevor Wilson | Trevor Wilson | Ed Whitson | Dave Righetti | 297 | 331 | -34 |
| 1991-06-30 | vs SFN | 77 | L 7-8 | 38-39 | 4 | 23,212 | Andy Benes | Mike Remlinger | Jeff Brantley | Craig Lefferts | | 304 | 339 | -35 |
| 1991-07-02 | vs LAN | 78 | L 1-4 | 38-40 | 4 | 31,543 | Dennis Rasmussen | Ramon Martinez | Ramon Martinez | Dennis Rasmussen | Tim Crews | 305 | 343 | -38 |
| 1991-07-03 | vs LAN | 79 | L 3-6 | 38-41 | 4 | 35,941 | Bruce Hurst | Bob Ojeda | Bob Ojeda | Bruce Hurst | | 308 | 349 | -41 |
| 1991-07-04 | vs LAN | 80 | W 5-4 | 39-41 | 4 | 40,446 | Greg Harris | Mike Morgan | Jose Melendez | Jim Gott | | 313 | 353 | -40 |
| 1991-07-05 | @ SFN | 81 | W 4-2 | 40-41 | 4 | 13,788 | Ed Whitson | Mike Remlinger | Ed Whitson | Mike Remlinger | Mike Maddux | 317 | 355 | -38 |
| 1991-07-06 | @ SFN | 82 | L 1-4 | 40-42 | 4 | 27,706 | Andy Benes | Don Robinson | Don Robinson | Andy Benes | Dave Righetti | 318 | 359 | -41 |
| 1991-07-07 | @ SFN | 83 | L 0-3 | 40-43 | 4 | 22,568 | Dennis Rasmussen | John Burkett | John Burkett | Dennis Rasmussen | | 318 | 362 | -44 |
| 1991-07-11 | @ NYN | 84 | L 3-4 | 40-44 | 4 | 32,208 | Bruce Hurst | Dwight Gooden | John Franco | Larry Andersen | | 321 | 366 | -45 |
| 1991-07-12 | @ NYN | 85 | L 3-6 | 40-45 | 4 | 30,706 | Adam Peterson | Frank Viola | Frank Viola | Adam Peterson | Alejandro Pena | 324 | 372 | -48 |
| 1991-07-13 | @ NYN | 86 | L 1-3 | 40-46 | 4 | 33,149 | Dennis Rasmussen | David Cone | David Cone | Dennis Rasmussen | John Franco | 325 | 375 | -50 |
| 1991-07-14 | @ NYN | 87 | W 2-1 | 41-46 | 4 | 46,836 | Greg Harris | Ron Darling | Greg Harris | Ron Darling | Craig Lefferts | 327 | 376 | -49 |
| 1991-07-15 | @ MON | 88 | L 0-3 | 41-47 | 4 | 12,369 | Andy Benes | Chris Haney | Chris Haney | Andy Benes | Jeff Fassero | 327 | 379 | -52 |
| 1991-07-16 | @ MON | 89 | W 4-3 | 42-47 | 4 | 19,536 | Bruce Hurst | Mark Gardner | Bruce Hurst | Mel Rojas | Larry Andersen | 331 | 382 | -51 |
| 1991-07-17 | @ MON | 90 | W 7-5 | 43-47 | 4 | 12,880 | Adam Peterson | Dennis Martinez | Jose Melendez | Dennis Martinez | Larry Andersen | 338 | 387 | -49 |
| 1991-07-19 | vs PHI | 91 | L 1-4 | 43-48 | 4 | 21,621 | Dennis Rasmussen | Jose De Jesus | Jose De Jesus | Dennis Rasmussen | Mitch Williams | 339 | 391 | -52 |
| 1991-07-20 | vs PHI | 92 | L 0-4 | 43-49 | 4 | 15,882 | Greg Harris | Bruce Ruffin | Bruce Ruffin | Greg Harris | | 339 | 395 | -56 |
| 1991-07-21 | vs PHI | 93 | W 5-2 | 44-49 | 4 | 18,053 | Bruce Hurst | Terry Mulholland | Bruce Hurst | Terry Mulholland | | 344 | 397 | -53 |
| 1991-07-23 | vs MON | 94 | W 2-1 | 45-49 | 4 | 14,007 | Andy Benes | Dennis Martinez | Larry Andersen | Dave J. Schmidt | | 346 | 398 | -52 |
| 1991-07-24 | vs MON | 95 | L 2-8 | 45-50 | 4 | 13,718 | Dennis Rasmussen | Brian Barnes | Brian Barnes | Dennis Rasmussen | Jeff Fassero | 348 | 406 | -58 |
| 1991-07-25 | vs MON | 96 | W 6-5 | 46-50 | 4 | 20,384 | Greg Harris | Ron Darling | Mike Maddux | Barry Jones | | 354 | 411 | -57 |
| 1991-07-26 | vs NYN | 97 | W 8-2 | 47-50 | 4 | 21,880 | Bruce Hurst | Sid Fernandez | Bruce Hurst | Sid Fernandez | | 362 | 413 | -51 |
| 1991-07-27 | vs NYN | 98 | L 0-4 | 47-51 | 4 | 31,304 | Adam Peterson | Dwight Gooden | Dwight Gooden | Adam Peterson | | 362 | 417 | -55 |
| 1991-07-28 | vs NYN | 99 | W 2-0 | 48-51 | 4 | 25,090 | Andy Benes | Frank Viola | Andy Benes | Frank Viola | Craig Lefferts | 364 | 417 | -53 |
| 1991-07-30 | @ PHI | 100 | L 1-2 | 48-52 | 5 | 22,946 | Dennis Rasmussen | Jose De Jesus | Jose De Jesus | Dennis Rasmussen | Mitch Williams | 365 | 419 | -54 |
| 1991-07-31 | @ PHI | 101 | L 3-9 | 48-53 | 5 | 24,779 | Greg Harris | Bruce Ruffin | Bruce Ruffin | Greg Harris | | 368 | 428 | -60 |
| 1991-08-02 | @ ATL | 102 | W 13-3 | 49-53 | 5 | 34,466 | Bruce Hurst | Charlie Leibrandt | Bruce Hurst | Charlie Leibrandt | | 381 | 431 | -50 |
| 1991-08-03 | @ ATL | 103 | W 3-2 | 50-53 | 5 | 42,067 | Andy Benes | Tom Glavine | Andy Benes | Tom Glavine | Larry Andersen | 384 | 433 | -49 |
| 1991-08-04 | @ ATL | 104 | L 7-9 | 50-54 | 5 | 25,006 | Dennis Rasmussen | Steve Avery | Steve Avery | Dennis Rasmussen | Juan Berenguer | 391 | 442 | -51 |
| 1991-08-05 | @ HOU | 105 | L 1-2 | 50-55 | 5 | 14,577 | Greg Harris | Pete Harnisch | Dwayne Henry | Larry Andersen | | 392 | 444 | -52 |
| 1991-08-06 | @ HOU | 106 | L 1-6 | 50-56 | 5 | 17,196 | Adam Peterson | Darryl Kile | Darryl Kile | Adam Peterson | Al Osuna | 393 | 450 | -57 |
| 1991-08-07 | @ HOU | 107 | W 7-4 | 51-56 | 5 | 19,305 | Bruce Hurst | Jimmy Jones | Bruce Hurst | Dean Wilkins | Larry Andersen | 400 | 454 | -54 |
| 1991-08-08 | @ HOU | 108 | W 5-3 | 52-56 | 5 | 22,606 | Andy Benes | Ryan Bowen | Andy Benes | Ryan Bowen | Craig Lefferts | 405 | 457 | -52 |
| 1991-08-09 | vs CIN | 109 | L 1-5 | 52-57 | 5 | 29,665 | Dennis Rasmussen | Mo Sanford | Mo Sanford | Dennis Rasmussen | | 406 | 462 | -56 |
| 1991-08-10 | vs CIN | 110 | W 1-0 | 53-57 | 5 | 36,861 | Greg Harris | Jose Rijo | Greg Harris | Jose Rijo | | 407 | 462 | -55 |
| 1991-08-11 | vs CIN | 111 | W 13-0 | 54-57 | 4 | 17,889 | Ricky Bones | Kip Gross | Ricky Bones | Kip Gross | | 420 | 462 | -42 |
| 1991-08-12 | vs HOU | 112 | W 6-5 | 55-57 | 4 | 13,896 | Bruce Hurst | Jimmy Jones | Jose Melendez | Mike Capel | Craig Lefferts | 426 | 467 | -41 |
| 1991-08-13 | vs HOU | 113 | L 9-12 | 55-58 | 4 | 12,688 | Andy Benes | Mark Portugal | Ryan Bowen | Mike Maddux | Al Osuna | 435 | 479 | -44 |
| 1991-08-14 | vs HOU | 114 | W 4-1 | 56-58 | 4 | 12,586 | Dennis Rasmussen | Jim Deshaies | Dennis Rasmussen | Jim Deshaies | Larry Andersen | 439 | 480 | -41 |
| 1991-08-15 | vs ATL | 115 | W 1-0 | 57-58 | 4 | 17,434 | Greg Harris | John Smoltz | Greg Harris | John Smoltz | | 440 | 480 | -40 |
| 1991-08-16 | vs ATL | 116 | L 2-3 | 57-59 | 4 | 19,049 | Ricky Bones | Armando Reynoso | Armando Reynoso | Ricky Bones | Mike Stanton | 442 | 483 | -41 |
| 1991-08-17 | vs ATL | 117 | L 1-2 | 57-60 | 4 | 39,551 | Bruce Hurst | Charlie Leibrandt | Charlie Leibrandt | Bruce Hurst | Mark Wohlers | 443 | 485 | -42 |
| 1991-08-18 | vs ATL | 118 | W 2-1 | 58-60 | 3 | 15,066 | Andy Benes | Tom Glavine | Andy Benes | Tom Glavine | Larry Andersen | 445 | 486 | -41 |
| 1991-08-19 | @ LAN | 119 | L 2-3 | 58-61 | 4 | 31,360 | Dennis Rasmussen | Tim Belcher | Kevin Gross | Larry Andersen | | 447 | 489 | -42 |
| 1991-08-20 | @ LAN | 120 | L 4-6 | 58-62 | 5 | 35,227 | Greg Harris | Ramon Martinez | Ramon Martinez | Greg Harris | Jay Howell | 451 | 495 | -44 |
| 1991-08-21 | @ LAN | 121 | L 5-9 | 58-63 | 5 | 32,864 | Ricky Bones | Orel Hershiser | Orel Hershiser | Ricky Bones | | 456 | 504 | -48 |
| 1991-08-23 | @ CHN | 122 | L 4-5 | 58-64 | 5 | 33,090 | Bruce Hurst | Mike Bielecki | Les Lancaster | Craig Lefferts | | 460 | 509 | -49 |
| 1991-08-24 | @ CHN | 123 | W 4-1 | 59-64 | 5 | 32,760 | Andy Benes | Greg Maddux | Andy Benes | Greg Maddux | Jose Melendez | 464 | 510 | -46 |
| 1991-08-25 | @ CHN | 124 | W 12-9 | 60-64 | 5 | 31,190 | Dennis Rasmussen | Danny Jackson | Mike Maddux | Bob Scanlan | Jose Melendez | 476 | 519 | -43 |
| 1991-08-26 | @ PIT | 125 | W 7-5 | 61-64 | 4 | 27,396 | Greg Harris | Randy Tomlin | Craig Lefferts | Bill Landrum | | 483 | 524 | -41 |
| 1991-08-27 | @ PIT | 126 | L 2-5 | 61-65 | 4 | 19,227 | Ricky Bones | Zane Smith | Zane Smith | Ricky Bones | Roger Mason | 485 | 529 | -44 |
| 1991-08-28 | @ SLN | 127 | W 2-1 | 62-65 | 4 | 20,479 | Bruce Hurst | Jose DeLeon | Bruce Hurst | Scott Terry | Craig Lefferts | 487 | 530 | -43 |
| 1991-08-29 | @ SLN | 128 | W 1-0 | 63-65 | 4 | 23,887 | Andy Benes | Omar Olivares | Andy Benes | Omar Olivares | | 488 | 530 | -42 |
| 1991-08-30 | vs PIT | 129 | L 1-4 | 63-66 | 4 | 21,726 | Dennis Rasmussen | John Smiley | John Smiley | Dennis Rasmussen | Rosario Rodriguez | 489 | 534 | -45 |
| 1991-08-31 | vs PIT | 130 | L 2-3 | 63-67 | 4 | 16,170 | Greg Harris | Randy Tomlin | Bill Landrum | Jose Melendez | Bob Kipper | 491 | 537 | -46 |
| 1991-09-01 | vs PIT | 131 | W 7-4 | 64-67 | 4 | 13,099 | Ricky Bones | Zane Smith | Ricky Bones | Zane Smith | Mike Maddux | 498 | 541 | -43 |
| 1991-09-02 | vs CHN | 132 | L 8-10 | 64-68 | 4 | 12,706 | Bruce Hurst | Mike Bielecki | Chuck McElroy | Jose Melendez | | 506 | 551 | -45 |
| 1991-09-03 | vs CHN | 133 | W 4-1 | 65-68 | 4 | 9,047 | Andy Benes | Greg Maddux | Andy Benes | Greg Maddux | | 510 | 552 | -42 |
| 1991-09-04 | vs CHN | 134 | W 5-1 | 66-68 | 4 | 9,952 | Dennis Rasmussen | Danny Jackson | Dennis Rasmussen | Danny Jackson | | 515 | 553 | -38 |
| 1991-09-05 | vs SLN | 135 | W 3-1 | 67-68 | 3 | 10,097 | Greg Harris | Bryn Smith | Greg Harris | Scott Terry | Jose Melendez | 518 | 554 | -36 |
| 1991-09-06 | vs SLN | 136 | W 6-2 | 68-68 | 3 | 14,791 | Ricky Bones | Bob Tewksbury | Ricky Bones | Bob Tewksbury | | 524 | 556 | -32 |
| 1991-09-07 | vs SLN | 137 | W 1-0 | 69-68 | 3 | 17,609 | Bruce Hurst | Ken Hill | Mike Maddux | Cris Carpenter | | 525 | 556 | -31 |
| 1991-09-09 | @ HOU | 138 | W 3-0 | 70-68 | 3 | 5,528 | Andy Benes | Mark Portugal | Andy Benes | Mark Portugal | Craig Lefferts | 528 | 556 | -28 |
| 1991-09-10 | @ HOU | 139 | W 7-6 | 71-68 | 3 | 4,353 | Dennis Rasmussen | Chris Gardner | Dennis Rasmussen | Chris Gardner | Craig Lefferts | 535 | 562 | -27 |
| 1991-09-11 | @ ATL | 140 | L 0-1 | 71-69 | 3 | 20,477 | Greg Harris | Kent Mercker | Kent Mercker | Greg Harris | Alejandro Pena | 535 | 563 | -28 |
| 1991-09-12 | @ ATL | 141 | L 1-5 | 71-70 | 3 | 27,794 | Bruce Hurst | Charlie Leibrandt | Charlie Leibrandt | Bruce Hurst | | 536 | 568 | -32 |
| 1991-09-13 | @ SFN | 142 | W 13-2 | 72-70 | 3 | 11,471 | Ricky Bones | Trevor Wilson | Ricky Bones | Trevor Wilson | | 549 | 570 | -21 |
| 1991-09-14 | @ SFN | 143 | W 3-1 | 73-70 | 3 | 19,439 | Andy Benes | Gil Heredia | Andy Benes | Gil Heredia | Mike Maddux | 552 | 571 | -19 |
| 1991-09-15 | @ SFN | 144 | L 2-7 | 73-71 | 3 | 14,049 | Dennis Rasmussen | John Burkett | John Burkett | Dennis Rasmussen | | 554 | 578 | -24 |
| 1991-09-16 | vs HOU | 145 | W 6-1 | 74-71 | 3 | 19,175 | Greg Harris | Brian Williams | Greg Harris | Brian Williams | Larry Andersen | 560 | 579 | -19 |
| 1991-09-17 | vs HOU | 146 | L 0-3 | 74-72 | 3 | 6,695 | Bruce Hurst | Pete Harnisch | Pete Harnisch | Bruce Hurst | Xavier Hernandez | 560 | 582 | -22 |
| 1991-09-18 | vs ATL | 147 | L 4-6 | 74-73 | 3 | 10,551 | Ricky Bones | Tom Glavine | Tom Glavine | Ricky Bones | Alejandro Pena | 564 | 588 | -24 |
| 1991-09-19 | vs ATL | 148 | L 2-4 | 74-74 | 3 | 13,556 | Andy Benes | John Smoltz | Mark Wohlers | Craig Lefferts | Alejandro Pena | 566 | 592 | -26 |
| 1991-09-20 | vs SFN | 149 | W 10-5 | 75-74 | 3 | 12,409 | Dennis Rasmussen | John Burkett | John Costello | John Burkett | Jeremy Hernandez | 576 | 597 | -21 |
| 1991-09-21 | vs SFN | 150 | W 3-2 | 76-74 | 3 | 10,954 | Greg Harris | Paul McClellan | Greg Harris | Paul McClellan | Larry Andersen | 579 | 599 | -20 |
| 1991-09-22 | vs SFN | 151 | W 6-3 | 77-74 | 3 | 25,486 | Jose Melendez | Buddy Black | Rich Rodriguez | Francisco Oliveras | Craig Lefferts | 585 | 602 | -17 |
| 1991-09-24 | vs LAN | 152 | L 2-5 | 77-75 | 3 | 19,169 | Ricky Bones | Mike Morgan | Mike Morgan | Ricky Bones | Roger McDowell | 587 | 607 | -20 |
| 1991-09-25 | vs LAN | 153 | W 8-2 | 78-75 | 3 | 25,668 | Andy Benes | Bob Ojeda | Andy Benes | Bob Ojeda | | 595 | 609 | -14 |
| 1991-09-27 | @ CIN | 154 | W 8-3 | 79-75 | 3 | 19,772 | Greg Harris | Scott Scudder | Greg Harris | Scott Scudder | Larry Andersen | 603 | 612 | -9 |
| 1991-09-28 | @ CIN | 155 | W 4-2 | 80-75 | 3 | 21,189 | Jose Melendez | Tom Browning | Jose Melendez | Tom Browning | Mike Maddux | 607 | 614 | -7 |
| 1991-09-29 | @ CIN | 156 | L 1-8 | 80-76 | 3 | 23,387 | Ricky Bones | Gino Minutelli | Ted Power | Ricky Bones | | 608 | 622 | -14 |
| 1991-09-30 | @ LAN | 157 | L 2-7 | 80-77 | 3 | 39,261 | Dennis Rasmussen | Orel Hershiser | Orel Hershiser | Dennis Rasmussen | | 610 | 629 | -19 |
| 1991-10-01 | @ LAN | 158 | L 1-3 | 80-78 | 3 | 42,827 | Andy Benes | Bob Ojeda | Bob Ojeda | Andy Benes | Roger McDowell | 611 | 632 | -21 |
| 1991-10-02 | @ LAN | 159 | W 9-4 | 81-78 | 3 | 48,358 | Greg Harris | Tim Belcher | Greg Harris | Kevin Gross | | 620 | 636 | -16 |
| 1991-10-04 | vs CIN | 160 | W 3-2 | 82-78 | 3 | 40,882 | Jose Melendez | Tom Browning | Jose Melendez | Tom Browning | Jeremy Hernandez | 623 | 638 | -15 |
| 1991-10-05 | vs CIN | 161 | W 10-7 | 83-78 | 3 | 17,847 | Ricky Bones | Jack Armstrong | Mike Maddux | Gino Minutelli | Craig Lefferts | 633 | 645 | -12 |
| 1991-10-06 | vs CIN | 162 | W 3-1 | 84-78 | 3 | 10,256 | Andy Benes | Jose Rijo | Andy Benes | Jose Rijo | Larry Andersen | 636 | 646 | -10 |