| 1991-04-08 | @ NYN | 1 | L 1-2 | 0-1 | 4 | 49,276 | Terry Mulholland | Dwight Gooden | Dwight Gooden | Terry Mulholland | John Franco | 1 | 2 | -1 |
| 1991-04-09 | @ NYN | 2 | L 1-2 | 0-2 | 6 | 16,013 | Jason Grimsley | Frank Viola | Doug Simons | Joe Boever | | 2 | 4 | -2 |
| 1991-04-10 | @ NYN | 3 | W 8-7 | 1-2 | 6 | 22,841 | Jose De Jesus | David Cone | Roger McDowell | Jeff Innis | Mitch Williams | 10 | 11 | -1 |
| 1991-04-12 | vs SLN | 4 | W 11-4 | 2-2 | 3 | 38,227 | Pat Combs | Jamie Moyer | Pat Combs | Jamie Moyer | | 21 | 15 | 6 |
| 1991-04-13 | vs SLN | 5 | W 4-2 | 3-2 | 2 | 15,485 | Terry Mulholland | Bob Tewksbury | Terry Mulholland | Bob Tewksbury | Mitch Williams | 25 | 17 | 8 |
| 1991-04-14 | vs SLN | 6 | L 7-11 | 3-3 | 3 | 20,337 | Dave LaPoint | Bryn Smith | Bryn Smith | Dave LaPoint | Lee Smith | 32 | 28 | 4 |
| 1991-04-15 | @ CHN | 7 | L 4-5 | 3-4 | 4 | 27,794 | Jason Grimsley | Greg Maddux | Greg Maddux | Jason Grimsley | Dave Smith | 36 | 33 | 3 |
| 1991-04-16 | @ CHN | 8 | L 3-4 | 3-5 | 5 | 11,571 | Jose De Jesus | Mike Harkey | Mike Bielecki | Mitch Williams | | 39 | 37 | 2 |
| 1991-04-17 | @ CHN | 9 | L 1-4 | 3-6 | 6 | 13,680 | Pat Combs | Shawn Boskie | Shawn Boskie | Pat Combs | Dave Smith | 40 | 41 | -1 |
| 1991-04-19 | @ SLN | 10 | L 1-3 | 3-7 | 6 | 21,468 | Terry Mulholland | Bob Tewksbury | Bob Tewksbury | Terry Mulholland | Lee Smith | 41 | 44 | -3 |
| 1991-04-20 | @ SLN | 11 | L 1-12 | 4-8 | 6 | 0 | Jason Grimsley | Jose DeLeon | Jose DeLeon | Jason Grimsley | Omar Olivares | 42 | 56 | -14 |
| 1991-04-20 | @ SLN | 12 | W 6-5 | 4-8 | 6 | 27,482 | Dave LaPoint | Bryn Smith | Roger McDowell | Cris Carpenter | Mitch Williams | 48 | 61 | -13 |
| 1991-04-21 | @ SLN | 13 | L 6-7 | 4-9 | 6 | 26,701 | Jose De Jesus | Ken Hill | Lee Smith | Mitch Williams | | 54 | 68 | -14 |
| 1991-04-23 | vs NYN | 14 | L 1-2 | 4-10 | 6 | 20,187 | Jason Grimsley | Ron Darling | Ron Darling | Jason Grimsley | John Franco | 55 | 70 | -15 |
| 1991-04-24 | vs NYN | 15 | L 3-7 | 4-11 | 6 | 15,214 | Terry Mulholland | Wally Whitehurst | Pete Schourek | Darrel Akerfelds | | 58 | 77 | -19 |
| 1991-04-25 | vs NYN | 16 | W 5-3 | 5-11 | 6 | 22,099 | Pat Combs | Dwight Gooden | Roger McDowell | Doug Simons | Mitch Williams | 63 | 80 | -17 |
| 1991-04-26 | vs SDN | 17 | L 0-4 | 5-12 | 6 | 19,363 | Jose De Jesus | Bruce Hurst | Bruce Hurst | Jose De Jesus | | 63 | 84 | -21 |
| 1991-04-27 | vs SDN | 18 | W 4-3 | 6-12 | 5 | 20,334 | Danny Cox | Andy Benes | Darrel Akerfelds | Mike Maddux | | 67 | 87 | -20 |
| 1991-04-28 | vs SDN | 19 | W 9-2 | 7-12 | 5 | 39,332 | Jason Grimsley | Eric Nolte | Jason Grimsley | Eric Nolte | | 76 | 89 | -13 |
| 1991-04-29 | vs SDN | 20 | W 7-2 | 8-12 | 5 | 12,359 | Terry Mulholland | Ed Whitson | Terry Mulholland | Ed Whitson | | 83 | 91 | -8 |
| 1991-04-30 | vs SFN | 21 | W 11-9 | 9-12 | 5 | 15,500 | Pat Combs | Buddy Black | Joe Boever | Jeff Brantley | Mitch Williams | 94 | 100 | -6 |
| 1991-05-01 | vs SFN | 22 | W 4-1 | 10-12 | 5 | 17,281 | Tommy Greene | Mike LaCoss | Tommy Greene | Mike LaCoss | Roger McDowell | 98 | 101 | -3 |
| 1991-05-03 | vs LAN | 23 | L 1-7 | 10-13 | 5 | 29,364 | Danny Cox | Ramon Martinez | Ramon Martinez | Danny Cox | | 99 | 108 | -9 |
| 1991-05-04 | vs LAN | 24 | W 4-3 | 11-13 | 5 | 30,106 | Terry Mulholland | Bob Ojeda | Terry Mulholland | Jay Howell | Mitch Williams | 103 | 111 | -8 |
| 1991-05-05 | vs LAN | 25 | L 2-3 | 11-14 | 5 | 44,160 | Jason Grimsley | Mike Morgan | Mike Morgan | Joe Boever | Jay Howell | 105 | 114 | -9 |
| 1991-05-07 | @ SDN | 26 | L 2-4 | 11-15 | 6 | 23,172 | Jose De Jesus | Bruce Hurst | Bruce Hurst | Jose De Jesus | Craig Lefferts | 107 | 118 | -11 |
| 1991-05-08 | @ SDN | 27 | W 5-2 | 12-15 | 6 | 12,063 | Danny Cox | Andy Benes | Danny Cox | Andy Benes | Roger McDowell | 112 | 120 | -8 |
| 1991-05-09 | @ SDN | 28 | W 9-6 | 13-15 | 5 | 43,153 | Terry Mulholland | Derek Lilliquist | Terry Mulholland | Derek Lilliquist | Mitch Williams | 121 | 126 | -5 |
| 1991-05-10 | @ LAN | 29 | L 1-3 | 13-16 | 6 | 44,255 | Jason Grimsley | Bob Ojeda | Bob Ojeda | Joe Boever | John Candelaria | 122 | 129 | -7 |
| 1991-05-11 | @ LAN | 30 | L 2-3 | 13-17 | 6 | 40,335 | Pat Combs | Mike Morgan | Mike Morgan | Pat Combs | Jay Howell | 124 | 132 | -8 |
| 1991-05-12 | @ LAN | 31 | W 7-3 | 14-17 | 6 | 33,208 | Jose De Jesus | Tim Belcher | Jose De Jesus | Tim Belcher | | 131 | 135 | -4 |
| 1991-05-13 | @ SFN | 32 | W 3-2 | 15-17 | 6 | 7,901 | Danny Cox | John Burkett | Joe Boever | Rod Beck | | 134 | 137 | -3 |
| 1991-05-14 | @ SFN | 33 | W 9-0 | 16-17 | 5 | 8,656 | Terry Mulholland | Kelly Downs | Terry Mulholland | Kelly Downs | | 143 | 137 | 6 |
| 1991-05-15 | @ SFN | 34 | L 2-4 | 16-18 | 5 | 12,661 | Jason Grimsley | Buddy Black | Buddy Black | Jason Grimsley | Jeff Brantley | 145 | 141 | 4 |
| 1991-05-17 | vs CHN | 35 | W 1-0 | 17-18 | 5 | 28,044 | Pat Combs | Greg Maddux | Tommy Greene | Les Lancaster | | 146 | 141 | 5 |
| 1991-05-18 | vs CHN | 36 | W 5-2 | 18-18 | 4 | 34,877 | Danny Cox | Shawn Boskie | Joe Boever | Paul Assenmacher | Mitch Williams | 151 | 143 | 8 |
| 1991-05-19 | vs CHN | 37 | L 1-2 | 18-19 | 6 | 27,830 | Terry Mulholland | Bob Scanlan | Mike Bielecki | Roger McDowell | Dave Smith | 152 | 145 | 7 |
| 1991-05-21 | @ MON | 38 | L 0-3 | 18-20 | 6 | 12,002 | Jason Grimsley | Dennis Martinez | Dennis Martinez | Jason Grimsley | | 152 | 148 | 4 |
| 1991-05-22 | @ MON | 39 | W 8-1 | 19-20 | 6 | 15,331 | Pat Combs | Brian Barnes | Pat Combs | Brian Barnes | | 160 | 149 | 11 |
| 1991-05-23 | @ MON | 40 | W 2-0 | 20-20 | 5 | 8,833 | Tommy Greene | Oil Can Boyd | Tommy Greene | Oil Can Boyd | | 162 | 149 | 13 |
| 1991-05-24 | @ PIT | 41 | L 1-9 | 20-21 | 5 | 29,770 | Terry Mulholland | Zane Smith | Zane Smith | Terry Mulholland | | 163 | 158 | 5 |
| 1991-05-25 | @ PIT | 42 | L 2-4 | 20-22 | 5 | 24,358 | Jose De Jesus | Bob Walk | Vicente Palacios | Joe Boever | | 165 | 162 | 3 |
| 1991-05-26 | @ PIT | 43 | L 2-5 | 20-23 | 5 | 26,117 | Jason Grimsley | John Smiley | John Smiley | Jason Grimsley | Bill Landrum | 167 | 167 | 0 |
| 1991-05-27 | vs MON | 44 | L 1-8 | 20-24 | 6 | 18,028 | Pat Combs | Chris Nabholz | Chris Nabholz | Pat Combs | | 168 | 175 | -7 |
| 1991-05-28 | vs MON | 45 | W 12-0 | 21-24 | 5 | 16,850 | Tommy Greene | Oil Can Boyd | Tommy Greene | Oil Can Boyd | | 180 | 175 | 5 |
| 1991-05-29 | vs MON | 46 | W 2-1 | 22-24 | 5 | 30,828 | Terry Mulholland | Mark Gardner | Terry Mulholland | Barry Jones | Mitch Williams | 182 | 176 | 6 |
| 1991-05-31 | vs PIT | 47 | L 1-5 | 22-25 | 5 | 25,652 | Jason Grimsley | Bob Walk | Bob Walk | Jason Grimsley | | 183 | 181 | 2 |
| 1991-06-01 | vs PIT | 48 | L 3-5 | 22-26 | 5 | 31,601 | Pat Combs | John Smiley | John Smiley | Pat Combs | Bill Landrum | 186 | 186 | 0 |
| 1991-06-02 | vs PIT | 49 | L 3-5 | 22-27 | 5 | 36,185 | Tommy Greene | Doug Drabek | Bob Walk | Mitch Williams | Bob Patterson | 189 | 191 | -2 |
| 1991-06-04 | @ ATL | 50 | L 5-9 | 22-28 | 5 | 30,165 | Terry Mulholland | Tom Glavine | Tom Glavine | Terry Mulholland | | 194 | 200 | -6 |
| 1991-06-05 | @ ATL | 51 | W 12-11 | 23-28 | 5 | 16,937 | Jason Grimsley | John Smoltz | Darrel Akerfelds | Jeff Parrett | Jose De Jesus | 206 | 211 | -5 |
| 1991-06-06 | @ ATL | 52 | L 4-9 | 23-29 | 5 | 15,682 | Pat Combs | Charlie Leibrandt | Charlie Leibrandt | Pat Combs | | 210 | 220 | -10 |
| 1991-06-07 | @ CIN | 53 | W 5-4 | 24-29 | 5 | 35,827 | Tommy Greene | Jack Armstrong | Tommy Greene | Jack Armstrong | Mitch Williams | 215 | 224 | -9 |
| 1991-06-08 | @ CIN | 54 | W 4-1 | 25-29 | 5 | 37,457 | Jose De Jesus | Chris Hammond | Jose De Jesus | Chris Hammond | Roger McDowell | 219 | 225 | -6 |
| 1991-06-09 | @ CIN | 55 | L 3-6 | 25-30 | 5 | 29,748 | Terry Mulholland | Tom Browning | Tom Browning | Terry Mulholland | Rob Dibble | 222 | 231 | -9 |
| 1991-06-10 | @ CIN | 56 | L 3-9 | 25-31 | 5 | 27,567 | Andy Ashby | Jose Rijo | Jose Rijo | Andy Ashby | | 225 | 240 | -15 |
| 1991-06-11 | @ HOU | 57 | L 0-1 | 25-32 | 5 | 7,953 | Pat Combs | Mark Portugal | Al Osuna | Roger McDowell | | 225 | 241 | -16 |
| 1991-06-12 | @ HOU | 58 | L 2-3 | 25-33 | 6 | 8,374 | Tommy Greene | Jim Deshaies | Al Osuna | Joe Boever | | 227 | 244 | -17 |
| 1991-06-13 | @ HOU | 59 | W 5-4 | 26-33 | 5 | 14,362 | Jose De Jesus | Darryl Kile | Jose De Jesus | Darryl Kile | Mitch Williams | 232 | 248 | -16 |
| 1991-06-14 | vs CIN | 60 | L 2-4 | 26-34 | 6 | 26,067 | Terry Mulholland | Tom Browning | Tom Browning | Terry Mulholland | Rob Dibble | 234 | 252 | -18 |
| 1991-06-15 | vs CIN | 61 | L 1-3 | 26-35 | 6 | 32,075 | Andy Ashby | Jose Rijo | Jose Rijo | Andy Ashby | Rob Dibble | 235 | 255 | -20 |
| 1991-06-16 | vs CIN | 62 | L 6-8 | 26-36 | 6 | 41,905 | Pat Combs | Norm Charlton | Randy Myers | Roger McDowell | Don Carman | 241 | 263 | -22 |
| 1991-06-17 | vs ATL | 63 | W 4-3 | 27-36 | 6 | 18,517 | Tommy Greene | Steve Avery | Mitch Williams | Juan Berenguer | | 245 | 266 | -21 |
| 1991-06-18 | vs ATL | 64 | W 8-4 | 28-36 | 6 | 12,405 | Jose De Jesus | Pete Smith | Jose De Jesus | Pete Smith | | 253 | 270 | -17 |
| 1991-06-19 | vs ATL | 65 | L 2-9 | 28-37 | 6 | 23,989 | Terry Mulholland | Tom Glavine | Tom Glavine | Terry Mulholland | | 255 | 279 | -24 |
| 1991-06-20 | vs HOU | 66 | W 7-3 | 29-37 | 6 | 23,415 | Danny Cox | Jimmy Jones | Danny Cox | Jimmy Jones | | 262 | 282 | -20 |
| 1991-06-21 | vs HOU | 67 | W 3-0 | 30-37 | 6 | 21,120 | Bruce Ruffin | Mark Portugal | Bruce Ruffin | Mark Portugal | Mitch Williams | 265 | 282 | -17 |
| 1991-06-22 | vs HOU | 68 | L 3-4 | 30-38 | 6 | 25,506 | Tommy Greene | Jim Deshaies | Al Osuna | Roger McDowell | Mike Capel | 268 | 286 | -18 |
| 1991-06-23 | vs HOU | 69 | L 4-6 | 30-39 | 6 | 23,455 | Jose De Jesus | Darryl Kile | Darryl Kile | Jose De Jesus | Jim Clancy | 272 | 292 | -20 |
| 1991-06-25 | @ SLN | 70 | L 9-10 | 30-40 | 6 | 30,798 | Danny Cox | Jose DeLeon | Scott Terry | Roger McDowell | Lee Smith | 281 | 302 | -21 |
| 1991-06-26 | @ SLN | 71 | L 1-14 | 30-41 | 6 | 25,706 | Pat Combs | Bryn Smith | Bryn Smith | Pat Combs | | 282 | 316 | -34 |
| 1991-06-27 | @ SLN | 72 | L 2-4 | 30-42 | 6 | 26,419 | Tommy Greene | Ken Hill | Ken Hill | Tommy Greene | Lee Smith | 284 | 320 | -36 |
| 1991-06-28 | @ NYN | 73 | W 6-2 | 31-42 | 6 | 33,511 | Jose De Jesus | Ron Darling | Jose De Jesus | Ron Darling | | 290 | 322 | -32 |
| 1991-06-29 | @ NYN | 74 | L 0-5 | 31-43 | 6 | 46,244 | Terry Mulholland | Wally Whitehurst | Wally Whitehurst | Terry Mulholland | | 290 | 327 | -37 |
| 1991-06-30 | @ NYN | 75 | W 10-9 | 32-43 | 6 | 44,310 | Danny Cox | Dwight Gooden | Danny Cox | Dwight Gooden | Mitch Williams | 300 | 336 | -36 |
| 1991-07-01 | vs SLN | 76 | L 0-1 | 32-44 | 6 | 17,281 | Bruce Ruffin | Bryn Smith | Bryn Smith | Bruce Ruffin | Lee Smith | 300 | 337 | -37 |
| 1991-07-02 | vs SLN | 77 | L 1-6 | 32-45 | 6 | 16,847 | Tommy Greene | Ken Hill | Ken Hill | Tommy Greene | Lee Smith | 301 | 343 | -42 |
| 1991-07-03 | vs SLN | 78 | L 3-4 | 32-46 | 6 | 50,156 | Jose De Jesus | Omar Olivares | Omar Olivares | Jose De Jesus | Lee Smith | 304 | 347 | -43 |
| 1991-07-04 | vs SLN | 79 | W 7-1 | 33-46 | 6 | 14,921 | Terry Mulholland | Bob Tewksbury | Terry Mulholland | Bob Tewksbury | | 311 | 348 | -37 |
| 1991-07-05 | vs NYN | 80 | L 1-3 | 33-47 | 6 | 51,314 | Danny Cox | Dwight Gooden | Dwight Gooden | Danny Cox | John Franco | 312 | 351 | -39 |
| 1991-07-06 | vs NYN | 81 | L 1-2 | 33-48 | 6 | 35,067 | Bruce Ruffin | Frank Viola | Frank Viola | Bruce Ruffin | John Franco | 313 | 353 | -40 |
| 1991-07-07 | vs NYN | 82 | L 2-8 | 33-49 | 6 | 35,444 | Tommy Greene | David Cone | David Cone | Tommy Greene | | 315 | 361 | -46 |
| 1991-07-11 | vs SFN | 83 | W 3-2 | 34-49 | 6 | 22,355 | Terry Mulholland | Trevor Wilson | Terry Mulholland | Trevor Wilson | Mitch Williams | 318 | 363 | -45 |
| 1991-07-12 | vs SFN | 84 | W 1-0 | 35-49 | 6 | 21,221 | Tommy Greene | Buddy Black | Tommy Greene | Buddy Black | Mitch Williams | 319 | 363 | -44 |
| 1991-07-13 | vs SFN | 85 | L 5-7 | 35-50 | 6 | 23,017 | Jose De Jesus | John Burkett | Francisco Oliveras | Wally Ritchie | Dave Righetti | 324 | 370 | -46 |
| 1991-07-14 | vs SFN | 86 | L 5-17 | 35-51 | 6 | 28,338 | Danny Cox | Mike Remlinger | Kelly Downs | Danny Cox | | 329 | 387 | -58 |
| 1991-07-15 | vs LAN | 87 | W 9-8 | 36-51 | 6 | 31,262 | Bruce Ruffin | Orel Hershiser | Steve Searcy | Tim Crews | Mitch Williams | 338 | 395 | -57 |
| 1991-07-16 | vs LAN | 88 | W 3-1 | 37-51 | 6 | 28,622 | Terry Mulholland | Bob Ojeda | Terry Mulholland | Bob Ojeda | | 341 | 396 | -55 |
| 1991-07-17 | vs LAN | 89 | W 4-2 | 38-51 | 6 | 33,651 | Tommy Greene | Mike Morgan | Tommy Greene | John Candelaria | Mitch Williams | 345 | 398 | -53 |
| 1991-07-19 | @ SDN | 90 | W 4-1 | 39-51 | 6 | 21,621 | Jose De Jesus | Dennis Rasmussen | Jose De Jesus | Dennis Rasmussen | Mitch Williams | 349 | 399 | -50 |
| 1991-07-20 | @ SDN | 91 | W 4-0 | 40-51 | 6 | 15,882 | Bruce Ruffin | Greg Harris | Bruce Ruffin | Greg Harris | | 353 | 399 | -46 |
| 1991-07-21 | @ SDN | 92 | L 2-5 | 40-52 | 6 | 18,053 | Terry Mulholland | Bruce Hurst | Bruce Hurst | Terry Mulholland | | 355 | 404 | -49 |
| 1991-07-23 | @ LAN | 93 | L 5-6 | 40-53 | 6 | 48,925 | Tommy Greene | Mike Morgan | Jay Howell | Roger McDowell | | 360 | 410 | -50 |
| 1991-07-24 | @ LAN | 94 | L 1-2 | 40-54 | 6 | 36,127 | Jose De Jesus | Tim Belcher | John Candelaria | Steve Searcy | | 361 | 412 | -51 |
| 1991-07-25 | @ LAN | 95 | L 0-5 | 40-55 | 6 | 39,626 | Bruce Ruffin | Ramon Martinez | Ramon Martinez | Bruce Ruffin | | 361 | 417 | -56 |
| 1991-07-26 | @ SFN | 96 | L 2-3 | 40-56 | 6 | 15,083 | Terry Mulholland | Kelly Downs | Kelly Downs | Terry Mulholland | Dave Righetti | 363 | 420 | -57 |
| 1991-07-27 | @ SFN | 97 | L 0-3 | 40-57 | 6 | 26,132 | Danny Cox | Paul McClellan | Paul McClellan | Danny Cox | Dave Righetti | 363 | 423 | -60 |
| 1991-07-28 | @ SFN | 98 | L 1-2 | 40-58 | 6 | 36,268 | Tommy Greene | Buddy Black | Buddy Black | Tommy Greene | Jeff Brantley | 364 | 425 | -61 |
| 1991-07-30 | vs SDN | 99 | W 2-1 | 41-58 | 6 | 22,946 | Jose De Jesus | Dennis Rasmussen | Jose De Jesus | Dennis Rasmussen | Mitch Williams | 366 | 426 | -60 |
| 1991-07-31 | vs SDN | 100 | W 9-3 | 42-58 | 6 | 24,779 | Bruce Ruffin | Greg Harris | Bruce Ruffin | Greg Harris | | 375 | 429 | -54 |
| 1991-08-01 | @ MON | 101 | W 4-1 | 43-58 | 6 | 24,953 | Terry Mulholland | Mark Gardner | Terry Mulholland | Mark Gardner | | 379 | 430 | -51 |
| 1991-08-02 | @ MON | 102 | W 6-5 | 44-58 | 5 | 18,638 | Danny Cox | Dennis Martinez | Mitch Williams | Mel Rojas | Mike Hartley | 385 | 435 | -50 |
| 1991-08-03 | @ MON | 103 | W 7-1 | 45-58 | 5 | 21,939 | Tommy Greene | Brian Barnes | Tommy Greene | Brian Barnes | | 392 | 436 | -44 |
| 1991-08-04 | @ MON | 104 | W 3-2 | 46-58 | 5 | 17,976 | Jose De Jesus | Chris Haney | Mitch Williams | Jeff Fassero | | 395 | 438 | -43 |
| 1991-08-06 | vs CHN | 105 | W 6-2 | 47-58 | 5 | 26,562 | Bruce Ruffin | Rick Sutcliffe | Mitch Williams | Les Lancaster | | 401 | 440 | -39 |
| 1991-08-07 | vs CHN | 106 | W 5-4 | 48-58 | 5 | 26,294 | Terry Mulholland | Mike Bielecki | Mitch Williams | Les Lancaster | | 406 | 444 | -38 |
| 1991-08-08 | vs CHN | 107 | W 11-1 | 49-58 | 5 | 32,232 | Danny Cox | Danny Jackson | Danny Cox | Danny Jackson | | 417 | 445 | -28 |
| 1991-08-09 | vs MON | 108 | W 5-4 | 50-58 | 5 | 13,297 | Tommy Greene | Brian Barnes | Mitch Williams | Dave Wainhouse | | 422 | 449 | -27 |
| 1991-08-10 | vs MON | 109 | W 4-2 | 51-58 | 5 | 31,006 | Jose De Jesus | Chris Haney | Jose De Jesus | Scott Ruskin | Mitch Williams | 426 | 451 | -25 |
| 1991-08-11 | vs MON | 110 | W 5-4 | 52-58 | 5 | 35,274 | Bruce Ruffin | Chris Nabholz | Mike Hartley | Jeff Fassero | Mitch Williams | 431 | 455 | -24 |
| 1991-08-12 | vs MON | 111 | W 2-1 | 53-58 | 5 | 31,001 | Terry Mulholland | Dennis Martinez | Terry Mulholland | Dennis Martinez | | 433 | 456 | -23 |
| 1991-08-13 | @ PIT | 112 | L 3-4 | 53-59 | 5 | 22,584 | Danny Cox | Doug Drabek | Doug Drabek | Danny Cox | Stan Belinda | 436 | 460 | -24 |
| 1991-08-14 | @ PIT | 113 | L 3-5 | 53-60 | 5 | 42,501 | Tommy Greene | John Smiley | John Smiley | Tommy Greene | Stan Belinda | 439 | 465 | -26 |
| 1991-08-15 | @ PIT | 114 | W 6-4 | 54-60 | 5 | 28,193 | Jose De Jesus | Hector Fajardo | Jose De Jesus | Neal Heaton | Mitch Williams | 445 | 469 | -24 |
| 1991-08-16 | @ CHN | 115 | L 1-9 | 54-61 | 5 | 34,547 | Bruce Ruffin | Rick Sutcliffe | Rick Sutcliffe | Bruce Ruffin | | 446 | 478 | -32 |
| 1991-08-17 | @ CHN | 116 | W 5-2 | 55-61 | 5 | 33,223 | Terry Mulholland | Mike Bielecki | Terry Mulholland | Mike Bielecki | Mitch Williams | 451 | 480 | -29 |
| 1991-08-18 | @ CHN | 117 | L 6-7 | 55-62 | 5 | 32,801 | Danny Cox | Danny Jackson | Paul Assenmacher | Mitch Williams | | 457 | 487 | -30 |
| 1991-08-20 | vs PIT | 118 | W 6-5 | 56-62 | 5 | 23,336 | Tommy Greene | John Smiley | Steve Searcy | Stan Belinda | | 463 | 492 | -29 |
| 1991-08-21 | vs PIT | 119 | W 6-5 | 57-62 | 5 | 35,591 | Jose De Jesus | Randy Tomlin | Mitch Williams | Bob Kipper | | 469 | 497 | -28 |
| 1991-08-22 | vs PIT | 120 | W 4-3 | 58-62 | 5 | 41,544 | Bruce Ruffin | Zane Smith | Mitch Williams | Bill Landrum | | 473 | 500 | -27 |
| 1991-08-23 | @ ATL | 121 | L 2-4 | 58-63 | 5 | 43,161 | Terry Mulholland | Tom Glavine | Tom Glavine | Terry Mulholland | Mark Wohlers | 475 | 504 | -29 |
| 1991-08-24 | @ ATL | 122 | W 6-5 | 59-63 | 5 | 43,966 | Danny Cox | John Smoltz | Mitch Williams | Tony Castillo | | 481 | 509 | -28 |
| 1991-08-25 | @ ATL | 123 | W 6-5 | 60-63 | 5 | 26,027 | Tommy Greene | Steve Avery | Tommy Greene | Steve Avery | Mitch Williams | 487 | 514 | -27 |
| 1991-08-26 | @ CIN | 124 | L 4-5 | 60-64 | 5 | 18,683 | Jose De Jesus | Mo Sanford | Kip Gross | Mike Hartley | Rob Dibble | 491 | 519 | -28 |
| 1991-08-27 | @ CIN | 125 | L 2-4 | 60-65 | 5 | 17,787 | Bruce Ruffin | Scott Scudder | Scott Scudder | Bruce Ruffin | Rob Dibble | 493 | 523 | -30 |
| 1991-08-28 | vs HOU | 126 | W 11-10 | 61-65 | 5 | 24,981 | Terry Mulholland | Ryan Bowen | Mike Hartley | Al Osuna | | 504 | 533 | -29 |
| 1991-08-29 | vs HOU | 127 | L 1-5 | 61-66 | 5 | 20,321 | Danny Cox | Mark Portugal | Mark Portugal | Danny Cox | | 505 | 538 | -33 |
| 1991-08-30 | vs ATL | 128 | L 1-6 | 61-67 | 5 | 22,708 | Tommy Greene | Steve Avery | Steve Avery | Tommy Greene | | 506 | 544 | -38 |
| 1991-08-31 | vs ATL | 129 | W 5-0 | 62-67 | 5 | 30,259 | Jose De Jesus | Armando Reynoso | Jose De Jesus | Armando Reynoso | | 511 | 544 | -33 |
| 1991-09-01 | vs ATL | 130 | W 5-4 | 63-67 | 5 | 25,141 | Bruce Ruffin | Charlie Leibrandt | Mitch Williams | Mark Wohlers | | 516 | 548 | -32 |
| 1991-09-02 | vs CIN | 131 | W 8-5 | 64-67 | 5 | 15,175 | Terry Mulholland | Tom Browning | Terry Mulholland | Tom Browning | Mitch Williams | 524 | 553 | -29 |
| 1991-09-03 | vs CIN | 132 | L 5-8 | 64-68 | 5 | 15,565 | Cliff Brantley | Jose Rijo | Jose Rijo | Cliff Brantley | Rob Dibble | 529 | 561 | -32 |
| 1991-09-04 | vs CIN | 133 | L 1-5 | 64-69 | 5 | 15,962 | Tommy Greene | Randy Myers | Randy Myers | Tommy Greene | | 530 | 566 | -36 |
| 1991-09-06 | @ HOU | 134 | L 1-3 | 64-70 | 5 | 7,868 | Jose De Jesus | Pete Harnisch | Pete Harnisch | Jose De Jesus | Al Osuna | 531 | 569 | -38 |
| 1991-09-07 | @ HOU | 135 | L 0-6 | 64-71 | 5 | 12,952 | Bruce Ruffin | Darryl Kile | Darryl Kile | Bruce Ruffin | | 531 | 575 | -44 |
| 1991-09-08 | @ HOU | 136 | W 5-0 | 65-71 | 5 | 7,847 | Terry Mulholland | Ryan Bowen | Terry Mulholland | Ryan Bowen | | 536 | 575 | -39 |
| 1991-09-09 | @ SLN | 137 | L 2-4 | 65-72 | 5 | 16,597 | Andy Ashby | Omar Olivares | Omar Olivares | Andy Ashby | Lee Smith | 538 | 579 | -41 |
| 1991-09-10 | @ SLN | 138 | W 5-2 | 66-72 | 5 | 16,210 | Tommy Greene | Rheal Cormier | Tommy Greene | Rheal Cormier | Mitch Williams | 543 | 581 | -38 |
| 1991-09-11 | vs MON | 139 | L 5-6 | 66-73 | 5 | 13,501 | Jose De Jesus | Chris Haney | Bill Sampen | Wally Ritchie | Barry Jones | 548 | 587 | -39 |
| 1991-09-12 | vs MON | 140 | L 2-6 | 66-74 | 5 | 13,243 | Bruce Ruffin | Chris Nabholz | Chris Nabholz | Bruce Ruffin | | 550 | 593 | -43 |
| 1991-09-13 | vs PIT | 141 | L 6-8 | 66-75 | 5 | 29,107 | Terry Mulholland | Bob Walk | Stan Belinda | Mitch Williams | Rosario Rodriguez | 556 | 601 | -45 |
| 1991-09-14 | vs PIT | 142 | L 3-5 | 66-76 | 5 | 27,412 | Andy Ashby | John Smiley | John Smiley | Andy Ashby | Vicente Palacios | 559 | 606 | -47 |
| 1991-09-15 | vs PIT | 143 | W 8-3 | 67-76 | 5 | 35,560 | Tommy Greene | Randy Tomlin | Tommy Greene | Randy Tomlin | Mitch Williams | 567 | 609 | -42 |
| 1991-09-16 | vs SLN | 144 | L 0-3 | 67-77 | 5 | 13,892 | Jose De Jesus | Bob Tewksbury | Bob Tewksbury | Jose De Jesus | Lee Smith | 567 | 612 | -45 |
| 1991-09-17 | vs SLN | 145 | W 4-2 | 68-77 | 5 | 14,059 | Cliff Brantley | Ken Hill | Cliff Brantley | Ken Hill | Mitch Williams | 571 | 614 | -43 |
| 1991-09-18 | vs MON | 146 | W 1-0 | 69-77 | 5 | 5,963 | Terry Mulholland | Dennis Martinez | Terry Mulholland | Dennis Martinez | | 572 | 614 | -42 |
| 1991-09-19 | vs MON | 147 | W 5-4 | 70-77 | 5 | 5,297 | Andy Ashby | Brian Barnes | Mitch Williams | Scott Ruskin | | 577 | 618 | -41 |
| 1991-09-20 | @ PIT | 148 | W 8-3 | 71-77 | 5 | 22,691 | Tommy Greene | Randy Tomlin | Tommy Greene | Randy Tomlin | | 585 | 621 | -36 |
| 1991-09-21 | @ PIT | 149 | L 0-7 | 71-78 | 5 | 27,162 | Jose De Jesus | Zane Smith | Zane Smith | Jose De Jesus | | 585 | 628 | -43 |
| 1991-09-22 | @ PIT | 150 | L 1-2 | 71-79 | 5 | 33,662 | Cliff Brantley | Doug Drabek | Doug Drabek | Cliff Brantley | | 586 | 630 | -44 |
| 1991-09-23 | @ CHN | 151 | L 3-10 | 71-80 | 5 | 16,141 | Terry Mulholland | Greg Maddux | Greg Maddux | Terry Mulholland | | 589 | 640 | -51 |
| 1991-09-24 | @ CHN | 152 | W 4-2 | 72-80 | 5 | 19,694 | Andy Ashby | Mike Bielecki | Andy Ashby | Mike Bielecki | Mitch Williams | 593 | 642 | -49 |
| 1991-09-25 | @ CHN | 153 | W 5-4 | 73-80 | 4 | 9,892 | Tommy Greene | Shawn Boskie | Tommy Greene | Shawn Boskie | Mitch Williams | 598 | 646 | -48 |
| 1991-09-27 | @ NYN | 154 | L 4-6 | 73-81 | 4 | 13,680 | Jose De Jesus | Pete Schourek | Pete Schourek | Jose De Jesus | John Franco | 602 | 652 | -50 |
| 1991-09-28 | @ NYN | 155 | W 6-2 | 74-81 | 4 | 16,967 | Cliff Brantley | Anthony Young | Cliff Brantley | Anthony Young | | 608 | 654 | -46 |
| 1991-09-29 | @ NYN | 156 | L 3-4 | 74-82 | 4 | 16,573 | Terry Mulholland | Frank Viola | Frank Viola | Terry Mulholland | John Franco | 611 | 658 | -47 |
| 1991-09-30 | vs CHN | 157 | W 6-5 | 75-82 | 4 | 12,109 | Andy Ashby | Shawn Boskie | Wally Ritchie | Paul Assenmacher | | 617 | 663 | -46 |
| 1991-10-01 | vs CHN | 158 | W 6-5 | 76-82 | 3 | 12,291 | Tommy Greene | Frank Castillo | Bruce Ruffin | Paul Assenmacher | | 623 | 668 | -45 |
| 1991-10-02 | vs CHN | 159 | L 0-1 | 76-83 | 4 | 13,680 | Jose De Jesus | Greg Maddux | Greg Maddux | Jose De Jesus | | 623 | 669 | -46 |
| 1991-10-04 | vs NYN | 160 | W 5-4 | 77-83 | 3 | 20,720 | Cliff Brantley | Frank Viola | Mitch Williams | John Franco | | 628 | 673 | -45 |
| 1991-10-05 | vs NYN | 161 | W 1-0 | 78-83 | 3 | 22,281 | Terry Mulholland | Anthony Young | Terry Mulholland | Anthony Young | | 629 | 673 | -44 |
| 1991-10-06 | vs NYN | 162 | L 0-7 | 78-84 | 3 | 29,676 | Andy Ashby | David Cone | David Cone | Andy Ashby | | 629 | 680 | -51 |