| 1991-04-09 | vs MIN | 1 | W 7-2 | 1-0 | 2 | 44,373 | Dave Stewart | Jack Morris | Dave Stewart | Jack Morris | | 7 | 2 | 5 |
| 1991-04-10 | vs MIN | 2 | L 1-4 | 1-1 | 5 | 22,958 | Bob Welch | Allan Anderson | Allan Anderson | Bob Welch | Rick Aguilera | 8 | 6 | 2 |
| 1991-04-11 | vs MIN | 3 | W 3-0 | 2-1 | 4 | 22,169 | Joe Slusarski | Scott Erickson | Joe Slusarski | Scott Erickson | Dennis Eckersley | 11 | 6 | 5 |
| 1991-04-12 | vs SEA | 4 | W 6-1 | 3-1 | 3 | 36,112 | Mike Moore | Scott Bankhead | Mike Moore | Scott Bankhead | | 17 | 7 | 10 |
| 1991-04-13 | vs SEA | 5 | W 4-2 | 4-1 | 2 | 38,126 | Kirk Dressendorfer | Rich DeLucia | Kirk Dressendorfer | Rich DeLucia | Dennis Eckersley | 21 | 9 | 12 |
| 1991-04-14 | vs SEA | 6 | W 7-6 | 5-1 | 2 | 28,949 | Dave Stewart | Erik Hanson | Dana Allison | Michael Jackson | | 28 | 15 | 13 |
| 1991-04-15 | @ CAL | 7 | W 5-2 | 6-1 | 2 | 44,339 | Bob Welch | Kirk McCaskill | Bob Welch | Kirk McCaskill | Dennis Eckersley | 33 | 17 | 16 |
| 1991-04-16 | @ CAL | 8 | W 8-5 | 7-1 | 2 | 26,813 | Joe Slusarski | Mark Langston | Steve Chitren | Scott Bailes | Dennis Eckersley | 41 | 22 | 19 |
| 1991-04-17 | @ CAL | 9 | W 3-1 | 8-1 | 1 | 28,685 | Mike Moore | Jim Abbott | Mike Moore | Jim Abbott | Joe Klink | 44 | 23 | 21 |
| 1991-04-18 | @ CAL | 10 | L 1-7 | 8-2 | 1 | 24,939 | Kirk Dressendorfer | Scott Lewis | Scott Lewis | Kirk Dressendorfer | | 45 | 30 | 15 |
| 1991-04-19 | @ SEA | 11 | L 7-11 | 8-3 | 2 | 24,009 | Dave Stewart | Rich DeLucia | Rich DeLucia | Dave Stewart | Rob Murphy | 52 | 41 | 11 |
| 1991-04-20 | @ SEA | 12 | L 2-3 | 8-4 | 2 | 51,412 | Bob Welch | Erik Hanson | Erik Hanson | Dennis Eckersley | | 54 | 44 | 10 |
| 1991-04-21 | @ SEA | 13 | L 2-7 | 8-5 | 2 | 30,191 | Joe Slusarski | Randy Johnson | Randy Johnson | Dana Allison | | 56 | 51 | 5 |
| 1991-04-22 | @ MIN | 14 | L 2-3 | 8-6 | 2 | 12,998 | Mike Moore | Kevin Tapani | Steve Bedrosian | Joe Klink | Rick Aguilera | 58 | 54 | 4 |
| 1991-04-23 | @ MIN | 15 | W 7-5 | 9-6 | 2 | 12,574 | Kirk Dressendorfer | Mark Guthrie | Kirk Dressendorfer | Mark Guthrie | Dennis Eckersley | 65 | 59 | 6 |
| 1991-04-24 | @ MIN | 16 | L 4-7 | 9-7 | 2 | 18,950 | Dave Stewart | Jack Morris | Jack Morris | Dave Stewart | Rick Aguilera | 69 | 66 | 3 |
| 1991-04-26 | vs CAL | 17 | W 4-1 | 10-7 | 2 | 40,262 | Bob Welch | Kirk McCaskill | Bob Welch | Kirk McCaskill | Dennis Eckersley | 73 | 67 | 6 |
| 1991-04-27 | vs CAL | 18 | W 4-3 | 11-7 | 2 | 36,947 | Mike Moore | Mark Langston | Mike Moore | Mark Langston | Dennis Eckersley | 77 | 70 | 7 |
| 1991-04-28 | vs CAL | 19 | W 7-3 | 12-7 | 2 | 40,174 | Dave Stewart | Jim Abbott | Dave Stewart | Jim Abbott | | 84 | 73 | 11 |
| 1991-04-30 | vs NYA | 20 | W 7-3 | 13-7 | 1 | 40,239 | Bob Welch | Dave Eiland | Bob Welch | Dave Eiland | | 91 | 76 | 15 |
| 1991-05-01 | vs NYA | 21 | W 7-4 | 14-7 | 1 | 36,139 | Mike Moore | Tim Leary | Mike Moore | Tim Leary | Dennis Eckersley | 98 | 80 | 18 |
| 1991-05-03 | vs CLE | 22 | W 4-3 | 15-7 | 1 | 25,252 | Dave Stewart | Charles Nagy | Joe Klink | Steve Olin | | 102 | 83 | 19 |
| 1991-05-04 | vs CLE | 23 | L 6-20 | 15-8 | 1 | 35,028 | Kirk Dressendorfer | Eric King | Eric King | Kirk Dressendorfer | | 108 | 103 | 5 |
| 1991-05-05 | vs CLE | 24 | L 6-15 | 15-9 | 1 | 44,164 | Bob Welch | Greg Swindell | Greg Swindell | Bob Welch | | 114 | 118 | -4 |
| 1991-05-07 | vs BAL | 25 | W 11-3 | 16-9 | 1 | 22,908 | Mike Moore | Ben McDonald | Mike Moore | Ben McDonald | | 125 | 121 | 4 |
| 1991-05-08 | vs BAL | 26 | W 9-3 | 17-9 | 1 | 23,528 | Dave Stewart | Mike Flanagan | Curt Young | Mike Flanagan | | 134 | 124 | 10 |
| 1991-05-10 | @ NYA | 27 | L 3-5 | 17-10 | 1 | 25,336 | Bob Welch | Chuck Cary | John Habyan | Joe Klink | Steve Farr | 137 | 129 | 8 |
| 1991-05-11 | @ NYA | 28 | W 10-2 | 18-10 | 1 | 30,967 | Kirk Dressendorfer | Dave Eiland | Kirk Dressendorfer | Dave Eiland | | 147 | 131 | 16 |
| 1991-05-12 | @ NYA | 29 | L 6-10 | 18-11 | 1 | 25,212 | Mike Moore | Tim Leary | Steve Farr | Mike Moore | | 153 | 141 | 12 |
| 1991-05-13 | @ NYA | 30 | L 3-6 | 18-12 | 1 | 17,691 | Curt Young | Scott Sanderson | Scott Sanderson | Curt Young | Lee Guetterman | 156 | 147 | 9 |
| 1991-05-14 | @ BAL | 31 | L 1-6 | 18-13 | 1 | 24,006 | Joe Slusarski | Jeff Robinson | Jeff Robinson | Joe Slusarski | | 157 | 153 | 4 |
| 1991-05-15 | @ BAL | 32 | W 6-3 | 19-13 | 1 | 32,596 | Bob Welch | Jeff Ballard | Bob Welch | Jeff Ballard | Dennis Eckersley | 163 | 156 | 7 |
| 1991-05-16 | @ BAL | 33 | W 11-5 | 20-13 | 1 | 32,414 | Kirk Dressendorfer | Jose Mesa | Joe Klink | Jose Mesa | | 174 | 161 | 13 |
| 1991-05-17 | @ CLE | 34 | L 6-11 | 20-14 | 2 | 43,717 | Mike Moore | Tom Candiotti | Tom Candiotti | Mike Moore | | 180 | 172 | 8 |
| 1991-05-18 | @ CLE | 35 | W 3-0 | 21-14 | 2 | 20,963 | Andy Hawkins | Charles Nagy | Andy Hawkins | Charles Nagy | Dennis Eckersley | 183 | 172 | 11 |
| 1991-05-19 | @ CLE | 36 | W 9-4 | 22-14 | 1 | 29,465 | Joe Slusarski | Rod Nichols | Curt Young | Rod Nichols | | 192 | 176 | 16 |
| 1991-05-20 | vs TOR | 37 | L 0-1 | 22-15 | 2 | 24,631 | Bob Welch | David Wells | David Wells | Bob Welch | Tom Henke | 192 | 177 | 15 |
| 1991-05-21 | vs TOR | 38 | L 7-11 | 22-16 | 2 | 22,738 | Kirk Dressendorfer | Jim Acker | Jim Acker | Kirk Dressendorfer | Mike Timlin | 199 | 188 | 11 |
| 1991-05-22 | vs TOR | 39 | W 2-1 | 23-16 | 1 | 34,028 | Mike Moore | Dave Stieb | Mike Moore | Dave Stieb | Dennis Eckersley | 201 | 189 | 12 |
| 1991-05-23 | vs CHA | 40 | L 1-11 | 23-17 | 2 | 30,145 | Andy Hawkins | Greg Hibbard | Greg Hibbard | Andy Hawkins | | 202 | 200 | 2 |
| 1991-05-24 | vs CHA | 41 | W 6-5 | 24-17 | 2 | 34,478 | Joe Slusarski | Jack McDowell | Dennis Eckersley | Bobby Thigpen | | 208 | 205 | 3 |
| 1991-05-25 | vs CHA | 42 | W 5-3 | 25-17 | 2 | 41,587 | Bob Welch | Melido Perez | Joe Klink | Wayne Edwards | | 213 | 208 | 5 |
| 1991-05-26 | vs CHA | 43 | W 6-2 | 26-17 | 2 | 44,089 | Dave Stewart | Alex Fernandez | Dave Stewart | Alex Fernandez | Joe Klink | 219 | 210 | 9 |
| 1991-05-28 | @ TOR | 44 | W 8-4 | 27-17 | 2 | 50,299 | Mike Moore | Jim Acker | Mike Moore | Jim Acker | Dennis Eckersley | 227 | 214 | 13 |
| 1991-05-29 | @ TOR | 45 | L 3-8 | 27-18 | 2 | 50,262 | Joe Slusarski | Jimmy Key | Jimmy Key | Joe Slusarski | Tom Henke | 230 | 222 | 8 |
| 1991-05-30 | @ TOR | 46 | W 8-6 | 28-18 | 1 | 50,271 | Bob Welch | Todd Stottlemyre | Joe Klink | Duane Ward | Dennis Eckersley | 238 | 228 | 10 |
| 1991-05-31 | @ CHA | 47 | L 4-5 | 28-19 | 2 | 41,870 | Dave Stewart | Ramon Garcia | Bobby Thigpen | Steve Chitren | | 242 | 233 | 9 |
| 1991-06-01 | @ CHA | 48 | W 7-4 | 29-19 | 1 | 42,343 | Andy Hawkins | Alex Fernandez | Joe Klink | Alex Fernandez | Dennis Eckersley | 249 | 237 | 12 |
| 1991-06-02 | @ CHA | 49 | L 3-4 | 29-20 | 1 | 41,358 | Mike Moore | Charlie Hough | Charlie Hough | Mike Moore | Bobby Thigpen | 252 | 241 | 11 |
| 1991-06-03 | @ CHA | 50 | W 5-3 | 30-20 | 1 | 36,341 | Joe Slusarski | Greg Hibbard | Joe Slusarski | Greg Hibbard | Dennis Eckersley | 257 | 244 | 13 |
| 1991-06-04 | vs MIL | 51 | W 4-3 | 31-20 | 1 | 22,214 | Bob Welch | Jaime Navarro | Bob Welch | Jaime Navarro | Dennis Eckersley | 261 | 247 | 14 |
| 1991-06-05 | vs MIL | 52 | W 6-4 | 32-20 | 1 | 21,271 | Dave Stewart | Chris Bosio | Dave Stewart | Chris Bosio | Steve Chitren | 267 | 251 | 16 |
| 1991-06-06 | vs MIL | 53 | W 9-8 | 33-20 | 1 | 26,365 | Andy Hawkins | Don August | Bruce Walton | Chuck Crim | Dennis Eckersley | 276 | 259 | 17 |
| 1991-06-07 | vs BOS | 54 | L 1-3 | 33-21 | 1 | 37,365 | Mike Moore | Greg Harris | Greg Harris | Mike Moore | Jeff Reardon | 277 | 262 | 15 |
| 1991-06-08 | vs BOS | 55 | L 1-8 | 33-22 | 1 | 44,347 | Joe Slusarski | Roger Clemens | Roger Clemens | Joe Slusarski | | 278 | 270 | 8 |
| 1991-06-09 | vs BOS | 56 | W 8-0 | 34-22 | 1 | 44,595 | Bob Welch | Tom Bolton | Bob Welch | Tom Bolton | | 286 | 270 | 16 |
| 1991-06-10 | vs DET | 57 | W 12-6 | 35-22 | 1 | 22,499 | Dave Stewart | Kevin Ritz | Johnny Guzman | Mike Henneman | | 298 | 276 | 22 |
| 1991-06-11 | vs DET | 58 | L 1-5 | 35-23 | 1 | 27,014 | Andy Hawkins | Bill Gullickson | Bill Gullickson | Andy Hawkins | Mike Henneman | 299 | 281 | 18 |
| 1991-06-12 | vs DET | 59 | W 3-1 | 36-23 | 1 | 30,404 | Mike Moore | Frank Tanana | Mike Moore | Frank Tanana | Dennis Eckersley | 302 | 282 | 20 |
| 1991-06-15 | @ MIL | 60 | L 4-6 | 37-24 | 1 | 0 | Dave Stewart | Jaime Navarro | Jaime Navarro | Dave Stewart | Dan Plesac | 306 | 288 | 18 |
| 1991-06-15 | @ MIL | 61 | W 7-3 | 37-24 | 1 | 33,797 | Andy Hawkins | Kevin Brown | Andy Hawkins | Kevin Brown | Steve Chitren | 313 | 291 | 22 |
| 1991-06-16 | @ MIL | 62 | L 7-11 | 37-25 | 2 | 28,774 | Joe Slusarski | Chris Bosio | Chuck Crim | Gene Nelson | | 320 | 302 | 18 |
| 1991-06-17 | @ MIL | 63 | L 0-5 | 37-26 | 2 | 20,431 | Mike Moore | Don August | Don August | Mike Moore | | 320 | 307 | 13 |
| 1991-06-18 | @ DET | 64 | L 0-2 | 37-27 | 2 | 23,664 | Bob Welch | Frank Tanana | Frank Tanana | Bob Welch | Mike Henneman | 320 | 309 | 11 |
| 1991-06-19 | @ DET | 65 | W 5-4 | 38-27 | 2 | 22,658 | Andy Hawkins | Walt Terrell | Gene Nelson | Walt Terrell | Dennis Eckersley | 325 | 313 | 12 |
| 1991-06-20 | @ BOS | 66 | L 7-8 | 38-28 | 2 | 33,769 | Dave Stewart | Mike Gardiner | Jeff Gray | Steve Chitren | Jeff Reardon | 332 | 321 | 11 |
| 1991-06-21 | @ BOS | 67 | L 2-3 | 38-29 | 2 | 33,951 | Mike Moore | Tom Bolton | Tom Bolton | Mike Moore | Jeff Reardon | 334 | 324 | 10 |
| 1991-06-22 | @ BOS | 68 | L 5-9 | 38-30 | 2 | 34,120 | Joe Slusarski | Greg Harris | Greg Harris | Joe Slusarski | | 339 | 333 | 6 |
| 1991-06-23 | @ BOS | 69 | W 4-2 | 39-30 | 2 | 34,147 | Bob Welch | Danny Darwin | Bob Welch | Danny Darwin | Dennis Eckersley | 343 | 335 | 8 |
| 1991-06-25 | vs TEX | 70 | L 1-6 | 39-31 | 2 | 37,195 | Dave Stewart | Jose Guzman | Jose Guzman | Dave Stewart | | 344 | 341 | 3 |
| 1991-06-26 | vs TEX | 71 | L 1-8 | 39-32 | 3 | 25,686 | Mike Moore | Kevin Brown | Kevin Brown | Gene Nelson | | 345 | 349 | -4 |
| 1991-06-27 | vs TEX | 72 | L 6-9 | 39-33 | 4 | 38,387 | Andy Hawkins | Terry Mathews | Wayne Rosenthal | Rick Honeycutt | Jeff Russell | 351 | 358 | -7 |
| 1991-06-28 | vs KCA | 73 | L 0-11 | 39-34 | 4 | 29,006 | Bob Welch | Luis Aquino | Luis Aquino | Bob Welch | | 351 | 369 | -18 |
| 1991-06-29 | vs KCA | 74 | W 6-3 | 40-34 | 4 | 43,020 | Dave Stewart | Kevin Appier | Dave Stewart | Storm Davis | Dennis Eckersley | 357 | 372 | -15 |
| 1991-06-30 | vs KCA | 75 | W 3-2 | 41-34 | 4 | 40,274 | Mike Moore | Tom Gordon | Mike Moore | Tom Gordon | Dennis Eckersley | 360 | 374 | -14 |
| 1991-07-01 | vs KCA | 76 | L 3-7 | 41-35 | 4 | 44,227 | Andy Hawkins | Mike Boddicker | Mike Boddicker | Andy Hawkins | Jeff Montgomery | 363 | 381 | -18 |
| 1991-07-02 | @ TEX | 77 | L 6-9 | 41-36 | 5 | 41,172 | Bob Welch | Nolan Ryan | Kenny Rogers | Rick Honeycutt | Jeff Russell | 369 | 390 | -21 |
| 1991-07-03 | @ TEX | 78 | W 5-0 | 42-36 | 5 | 37,698 | Dave Stewart | John Barfield | Dave Stewart | John Barfield | | 374 | 390 | -16 |
| 1991-07-04 | @ TEX | 79 | L 4-5 | 42-37 | 5 | 41,652 | Mike Moore | Gerald Alexander | Jeff Russell | Gene Nelson | | 378 | 395 | -17 |
| 1991-07-05 | @ KCA | 80 | W 9-3 | 43-37 | 5 | 40,762 | Andy Hawkins | Tom Gordon | Andy Hawkins | Tom Gordon | Steve Chitren | 387 | 398 | -11 |
| 1991-07-06 | @ KCA | 81 | W 9-7 | 44-37 | 4 | 39,509 | Bob Welch | Mike Boddicker | Bob Welch | Mike Boddicker | Dennis Eckersley | 396 | 405 | -9 |
| 1991-07-07 | @ KCA | 82 | L 5-7 | 44-38 | 5 | 31,272 | Dave Stewart | Mark Gubicza | Mark Gubicza | Dave Stewart | | 401 | 412 | -11 |
| 1991-07-11 | vs BAL | 83 | W 8-1 | 45-38 | 3 | 34,015 | Dave Stewart | Jeff Robinson | Dave Stewart | Jeff Robinson | | 409 | 413 | -4 |
| 1991-07-12 | vs BAL | 84 | L 3-6 | 45-39 | 4 | 36,539 | Bob Welch | Ben McDonald | Ben McDonald | Curt Young | Gregg Olson | 412 | 419 | -7 |
| 1991-07-13 | vs BAL | 85 | L 0-2 | 45-40 | 4 | 40,047 | Eric Show | Bob Milacki | Bob Milacki | Eric Show | Gregg Olson | 412 | 421 | -9 |
| 1991-07-14 | vs BAL | 86 | W 3-2 | 46-40 | 4 | 31,425 | Mike Moore | Roy Smith | Todd Burns | Gregg Olson | | 415 | 423 | -8 |
| 1991-07-15 | vs CLE | 87 | W 6-1 | 47-40 | 4 | 23,467 | Andy Hawkins | Denis Boucher | Andy Hawkins | Denis Boucher | | 421 | 424 | -3 |
| 1991-07-16 | vs CLE | 88 | W 7-6 | 48-40 | 2 | 24,782 | Dave Stewart | Charles Nagy | Joe Klink | Doug Jones | | 428 | 430 | -2 |
| 1991-07-17 | vs CLE | 89 | L 1-2 | 48-41 | 2 | 40,158 | Bob Welch | Rod Nichols | Rod Nichols | Bob Welch | | 429 | 432 | -3 |
| 1991-07-18 | vs NYA | 90 | L 2-3 | 48-42 | 3 | 39,437 | Eric Show | Scott Kamieniecki | Scott Kamieniecki | Eric Show | Steve Howe | 431 | 435 | -4 |
| 1991-07-19 | vs NYA | 91 | L 0-3 | 48-43 | 4 | 35,537 | Mike Moore | Jeff Johnson | Jeff Johnson | Mike Moore | Steve Farr | 431 | 438 | -7 |
| 1991-07-20 | vs NYA | 92 | L 1-5 | 48-44 | 5 | 44,429 | Andy Hawkins | Wade Taylor | Wade Taylor | Andy Hawkins | | 432 | 443 | -11 |
| 1991-07-21 | vs NYA | 93 | W 4-2 | 49-44 | 4 | 43,007 | Dave Stewart | Scott Sanderson | Dave Stewart | Scott Sanderson | Dennis Eckersley | 436 | 445 | -9 |
| 1991-07-23 | @ CLE | 94 | W 10-7 | 50-44 | 4 | 26,191 | Bob Welch | Rod Nichols | Rick Honeycutt | Jeff Shaw | | 446 | 452 | -6 |
| 1991-07-24 | @ CLE | 95 | W 8-4 | 51-44 | 4 | 14,553 | Eric Show | Greg Swindell | Eric Show | Greg Swindell | | 454 | 456 | -2 |
| 1991-07-25 | @ CLE | 96 | L 7-8 | 51-45 | 4 | 15,321 | Andy Hawkins | Dave Otto | Mike York | Dennis Eckersley | Steve Olin | 461 | 464 | -3 |
| 1991-07-26 | @ BAL | 97 | W 12-9 | 52-45 | 3 | 43,207 | Dave Stewart | Jeff Robinson | Joe Klink | Mark Williamson | Steve Chitren | 473 | 473 | 0 |
| 1991-07-27 | @ BAL | 98 | W 9-1 | 53-45 | 3 | 50,071 | Joe Slusarski | Jeff Ballard | Joe Slusarski | Jeff Ballard | | 482 | 474 | 8 |
| 1991-07-28 | @ BAL | 99 | W 4-3 | 54-45 | 3 | 48,341 | Bob Welch | Ben McDonald | Rick Honeycutt | Ben McDonald | Dennis Eckersley | 486 | 477 | 9 |
| 1991-07-29 | @ NYA | 100 | W 10-8 | 55-45 | 3 | 30,313 | Eric Show | Jeff Johnson | Kevin Campbell | Steve Howe | Dennis Eckersley | 496 | 485 | 11 |
| 1991-07-30 | @ NYA | 101 | W 6-5 | 56-45 | 3 | 36,803 | Andy Hawkins | Wade Taylor | Curt Young | Wade Taylor | Dennis Eckersley | 502 | 490 | 12 |
| 1991-07-31 | @ BOS | 102 | L 10-11 | 56-46 | 3 | 34,218 | Dave Stewart | Dana Kiecker | Greg Harris | Steve Chitren | | 512 | 501 | 11 |
| 1991-08-01 | @ BOS | 103 | W 4-2 | 57-46 | 3 | 34,099 | Eric Show | Mike Gardiner | Joe Klink | Dennis Lamp | Dennis Eckersley | 516 | 503 | 13 |
| 1991-08-02 | vs MIN | 104 | W 3-1 | 58-46 | 3 | 44,160 | Bob Welch | Jack Morris | Bob Welch | Jack Morris | | 519 | 504 | 15 |
| 1991-08-03 | vs MIN | 105 | L 6-8 | 58-47 | 3 | 43,119 | Joe Slusarski | David West | Steve Bedrosian | Joe Klink | Rick Aguilera | 525 | 512 | 13 |
| 1991-08-04 | vs MIN | 106 | L 2-6 | 58-48 | 3 | 44,088 | Dave Stewart | Scott Erickson | Scott Erickson | Dave Stewart | Carl Willis | 527 | 518 | 9 |
| 1991-08-05 | vs SEA | 107 | W 3-0 | 59-48 | 3 | 27,561 | Ron Darling | Bill Krueger | Ron Darling | Bill Krueger | Dennis Eckersley | 530 | 518 | 12 |
| 1991-08-06 | vs SEA | 108 | W 3-0 | 60-48 | 3 | 32,235 | Mike Moore | Rich DeLucia | Mike Moore | Rich DeLucia | Dennis Eckersley | 533 | 518 | 15 |
| 1991-08-07 | vs SEA | 109 | W 6-1 | 61-48 | 3 | 40,251 | Bob Welch | Brian Holman | Bob Welch | Brian Holman | | 539 | 519 | 20 |
| 1991-08-09 | @ CAL | 110 | W 5-4 | 62-48 | 3 | 41,169 | Dave Stewart | Kirk McCaskill | Dave Stewart | Kirk McCaskill | Dennis Eckersley | 544 | 523 | 21 |
| 1991-08-10 | @ CAL | 111 | W 3-1 | 63-48 | 3 | 44,385 | Ron Darling | Mark Langston | Ron Darling | Mark Langston | Dennis Eckersley | 547 | 524 | 23 |
| 1991-08-11 | @ CAL | 112 | W 3-2 | 64-48 | 3 | 41,424 | Mike Moore | Joe Grahe | Mike Moore | Joe Grahe | Dennis Eckersley | 550 | 526 | 24 |
| 1991-08-12 | @ SEA | 113 | L 3-6 | 64-49 | 3 | 41,967 | Bob Welch | Rich DeLucia | Rich DeLucia | Bob Welch | | 553 | 532 | 21 |
| 1991-08-13 | @ SEA | 114 | L 2-5 | 64-50 | 3 | 22,976 | Dave Stewart | Brian Holman | Brian Holman | Dave Stewart | Mike Schooler | 555 | 537 | 18 |
| 1991-08-14 | @ SEA | 115 | L 0-4 | 64-51 | 3 | 25,419 | Joe Slusarski | Randy Johnson | Randy Johnson | Joe Slusarski | | 555 | 541 | 14 |
| 1991-08-15 | @ SEA | 116 | L 6-8 | 64-52 | 3 | 32,006 | Ron Darling | Erik Hanson | Calvin Jones | Steve Chitren | Mike Schooler | 561 | 549 | 12 |
| 1991-08-16 | @ MIN | 117 | L 4-5 | 64-53 | 3 | 50,019 | Mike Moore | Kevin Tapani | Rick Aguilera | Gene Nelson | | 565 | 554 | 11 |
| 1991-08-17 | @ MIN | 118 | L 4-12 | 64-54 | 3 | 52,080 | Bob Welch | Jack Morris | Jack Morris | Bob Welch | | 569 | 566 | 3 |
| 1991-08-18 | @ MIN | 119 | L 4-6 | 64-55 | 3 | 44,295 | Dave Stewart | Willie Banks | Carl Willis | Rick Honeycutt | Rick Aguilera | 573 | 572 | 1 |
| 1991-08-19 | @ MIN | 120 | W 8-7 | 65-55 | 3 | 45,544 | Joe Slusarski | David West | Joe Klink | Steve Bedrosian | Dennis Eckersley | 581 | 579 | 2 |
| 1991-08-20 | vs CAL | 121 | W 3-2 | 66-55 | 3 | 32,341 | Ron Darling | Mark Langston | Ron Darling | Mark Langston | Dennis Eckersley | 584 | 581 | 3 |
| 1991-08-21 | vs CAL | 122 | W 2-0 | 67-55 | 3 | 29,126 | Mike Moore | Joe Grahe | Mike Moore | Joe Grahe | Dennis Eckersley | 586 | 581 | 5 |
| 1991-08-22 | vs CAL | 123 | W 2-1 | 68-55 | 3 | 36,549 | Bob Welch | Chuck Finley | Bob Welch | Chuck Finley | | 588 | 582 | 6 |
| 1991-08-23 | vs MIL | 124 | L 4-13 | 68-56 | 3 | 30,115 | Dave Stewart | Jaime Navarro | Jaime Navarro | Dave Stewart | | 592 | 595 | -3 |
| 1991-08-24 | vs MIL | 125 | L 0-7 | 68-57 | 3 | 41,317 | Joe Slusarski | Bill Wegman | Bill Wegman | Joe Slusarski | | 592 | 602 | -10 |
| 1991-08-25 | vs MIL | 126 | L 2-8 | 68-58 | 3 | 37,624 | Ron Darling | Chris Bosio | Chris Bosio | Ron Darling | | 594 | 610 | -16 |
| 1991-08-26 | vs BOS | 127 | L 0-3 | 68-59 | 3 | 28,869 | Mike Moore | Roger Clemens | Roger Clemens | Mike Moore | | 594 | 613 | -19 |
| 1991-08-27 | vs BOS | 128 | L 4-6 | 68-60 | 3 | 31,125 | Bob Welch | Mike Gardiner | Mike Gardiner | Bob Welch | Jeff Reardon | 598 | 619 | -21 |
| 1991-08-28 | vs BOS | 129 | W 9-3 | 69-60 | 2 | 34,793 | Dave Stewart | Matt Young | Dave Stewart | Matt Young | | 607 | 622 | -15 |
| 1991-08-30 | vs DET | 130 | W 6-3 | 70-60 | 2 | 31,774 | Ron Darling | Frank Tanana | Dennis Eckersley | Jerry Gleaton | | 613 | 625 | -12 |
| 1991-08-31 | vs DET | 131 | W 9-8 | 71-60 | 2 | 43,726 | Mike Moore | Walt Terrell | Dennis Eckersley | John Cerutti | | 622 | 633 | -11 |
| 1991-09-01 | vs DET | 132 | L 2-5 | 71-61 | 2 | 33,173 | Bob Welch | Mark Leiter | Mark Leiter | Bob Welch | Jerry Gleaton | 624 | 638 | -14 |
| 1991-09-03 | @ MIL | 133 | L 3-5 | 71-62 | 4 | 9,047 | Dave Stewart | Dan Plesac | Ed Nunez | Dennis Eckersley | | 627 | 643 | -16 |
| 1991-09-04 | @ MIL | 134 | L 0-2 | 71-63 | 4 | 12,599 | Ron Darling | Bill Wegman | Bill Wegman | Ron Darling | Doug Henry | 627 | 645 | -18 |
| 1991-09-05 | @ DET | 135 | W 4-1 | 72-63 | 3 | 16,953 | Mike Moore | Frank Tanana | Mike Moore | Frank Tanana | Dennis Eckersley | 631 | 646 | -15 |
| 1991-09-06 | @ DET | 136 | L 2-11 | 72-64 | 3 | 24,797 | Bob Welch | Walt Terrell | Walt Terrell | Bob Welch | | 633 | 657 | -24 |
| 1991-09-07 | @ DET | 137 | W 3-1 | 73-64 | 3 | 34,737 | Joe Slusarski | Mark Leiter | Joe Slusarski | Mark Leiter | Dennis Eckersley | 636 | 658 | -22 |
| 1991-09-08 | @ DET | 138 | W 7-4 | 74-64 | 3 | 28,873 | Dave Stewart | Bill Gullickson | Dave Stewart | Bill Gullickson | Dennis Eckersley | 643 | 662 | -19 |
| 1991-09-09 | vs CHA | 139 | L 1-7 | 74-65 | 3 | 23,055 | Ron Darling | Alex Fernandez | Alex Fernandez | Ron Darling | | 644 | 669 | -25 |
| 1991-09-10 | vs CHA | 140 | L 1-3 | 74-66 | 3 | 28,352 | Mike Moore | Charlie Hough | Melido Perez | Rick Honeycutt | Bobby Thigpen | 645 | 672 | -27 |
| 1991-09-11 | vs CHA | 141 | W 6-5 | 75-66 | 3 | 28,422 | Todd Van Poppel | Wilson Alvarez | Dennis Eckersley | Steve Wapnick | | 651 | 677 | -26 |
| 1991-09-13 | @ TOR | 142 | L 6-7 | 75-67 | 4 | 50,315 | Dave Stewart | Juan Guzman | Juan Guzman | Dave Stewart | Tom Henke | 657 | 684 | -27 |
| 1991-09-14 | @ TOR | 143 | L 0-6 | 75-68 | 4 | 50,319 | Bob Welch | Tom Candiotti | Tom Candiotti | Bob Welch | | 657 | 690 | -33 |
| 1991-09-15 | @ TOR | 144 | W 10-5 | 76-68 | 4 | 50,315 | Mike Moore | Todd Stottlemyre | Mike Moore | Todd Stottlemyre | Dennis Eckersley | 667 | 695 | -28 |
| 1991-09-17 | @ CHA | 145 | L 0-1 | 76-69 | 4 | 35,677 | Ron Darling | Greg Hibbard | Greg Hibbard | Ron Darling | Bobby Thigpen | 667 | 696 | -29 |
| 1991-09-18 | @ CHA | 146 | L 0-6 | 76-70 | 4 | 32,998 | Dave Stewart | Jack McDowell | Jack McDowell | Dave Stewart | | 667 | 702 | -35 |
| 1991-09-20 | vs TOR | 147 | W 6-5 | 77-70 | 4 | 33,765 | Bob Welch | Todd Stottlemyre | Dennis Eckersley | Duane Ward | | 673 | 707 | -34 |
| 1991-09-21 | vs TOR | 148 | W 4-0 | 78-70 | 3 | 36,601 | Mike Moore | Jimmy Key | Mike Moore | Jimmy Key | | 677 | 707 | -30 |
| 1991-09-22 | vs TOR | 149 | L 2-3 | 78-71 | 3 | 28,276 | Ron Darling | Juan Guzman | Juan Guzman | Ron Darling | David Wells | 679 | 710 | -31 |
| 1991-09-23 | vs KCA | 150 | W 7-6 | 79-71 | 3 | 29,255 | Dave Stewart | Luis Aquino | Joe Klink | Tom Gordon | Dennis Eckersley | 686 | 716 | -30 |
| 1991-09-24 | vs KCA | 151 | L 4-5 | 79-72 | 4 | 21,647 | Joe Slusarski | Kevin Appier | Kevin Appier | Joe Slusarski | Jeff Montgomery | 690 | 721 | -31 |
| 1991-09-25 | vs KCA | 152 | W 8-4 | 80-72 | 4 | 22,646 | Bob Welch | Mike Boddicker | Bob Welch | Mark Davis | Dennis Eckersley | 698 | 725 | -27 |
| 1991-09-26 | vs TEX | 153 | W 10-0 | 81-72 | 3 | 25,167 | Mike Moore | Oil Can Boyd | Mike Moore | Oil Can Boyd | | 708 | 725 | -17 |
| 1991-09-27 | vs TEX | 154 | L 0-3 | 81-73 | 4 | 24,134 | Ron Darling | Jose Guzman | Jose Guzman | Ron Darling | | 708 | 728 | -20 |
| 1991-09-28 | vs TEX | 155 | L 3-6 | 81-74 | 4 | 33,338 | Dave Stewart | Hector Fajardo | Terry Mathews | Dennis Eckersley | Jeff Russell | 711 | 734 | -23 |
| 1991-09-29 | vs TEX | 156 | W 19-5 | 82-74 | 4 | 40,853 | Joe Slusarski | Kevin Brown | Joe Slusarski | Kevin Brown | | 730 | 739 | -9 |
| 1991-09-30 | @ KCA | 157 | L 4-8 | 82-75 | 4 | 20,934 | Bob Welch | Mark Davis | Mark Davis | Bob Welch | | 734 | 747 | -13 |
| 1991-10-01 | @ KCA | 158 | W 4-0 | 83-75 | 3 | 17,638 | Mike Moore | Mark Gubicza | Mike Moore | Mark Gubicza | Dennis Eckersley | 738 | 747 | -9 |
| 1991-10-02 | @ KCA | 159 | L 5-16 | 83-76 | 3 | 18,552 | Ron Darling | Bret Saberhagen | Steve Crawford | Ron Darling | | 743 | 763 | -20 |
| 1991-10-04 | @ TEX | 160 | L 3-4 | 83-77 | 4 | 23,144 | Dave Stewart | Kevin Brown | Kenny Rogers | Dave Stewart | | 746 | 767 | -21 |
| 1991-10-05 | @ TEX | 161 | W 12-5 | 84-77 | 3 | 31,790 | Bob Welch | Hector Fajardo | Curt Young | Hector Fajardo | | 758 | 772 | -14 |
| 1991-10-06 | @ TEX | 162 | L 2-4 | 84-78 | 4 | 35,595 | Mike Moore | Nolan Ryan | Terry Mathews | Gene Nelson | | 760 | 776 | -16 |