| 1991-04-08 | @ DET | 1 | L 4-6 | 0-1 | 6 | 47,382 | Tim Leary | Frank Tanana | Paul Gibson | Greg Cadaret | Mike Henneman | 4 | 6 | -2 |
| 1991-04-10 | @ DET | 2 | W 4-0 | 1-1 | 4 | 7,842 | Scott Sanderson | Walt Terrell | Scott Sanderson | Walt Terrell | | 8 | 6 | 2 |
| 1991-04-11 | @ DET | 3 | L 5-11 | 1-2 | 5 | 8,392 | Dave Eiland | Bill Gullickson | Paul Gibson | John Habyan | | 13 | 17 | -4 |
| 1991-04-12 | @ KCA | 4 | L 5-9 | 1-3 | 7 | 27,100 | Chuck Cary | Storm Davis | Storm Davis | Chuck Cary | | 18 | 26 | -8 |
| 1991-04-13 | @ KCA | 5 | W 9-8 | 2-3 | 7 | 25,746 | Tim Leary | Bret Saberhagen | Tim Leary | Bret Saberhagen | Steve Farr | 27 | 34 | -7 |
| 1991-04-14 | @ KCA | 6 | L 3-5 | 2-4 | 7 | 30,005 | Andy Hawkins | Mike Boddicker | Mike Boddicker | Andy Hawkins | Jeff Montgomery | 30 | 39 | -9 |
| 1991-04-15 | vs CHA | 7 | L 5-6 | 2-5 | 7 | 50,891 | Scott Sanderson | Greg Hibbard | Greg Hibbard | Greg Cadaret | Bobby Thigpen | 35 | 45 | -10 |
| 1991-04-16 | vs CHA | 8 | L 3-4 | 2-6 | 7 | 17,541 | Dave Eiland | Melido Perez | Scott Radinsky | Steve Farr | Bobby Thigpen | 38 | 49 | -11 |
| 1991-04-17 | vs CHA | 9 | W 10-1 | 3-6 | 7 | 14,209 | Chuck Cary | Alex Fernandez | Chuck Cary | Alex Fernandez | | 48 | 50 | -2 |
| 1991-04-19 | vs KCA | 10 | W 3-1 | 4-6 | 7 | 15,773 | Tim Leary | Mike Boddicker | Tim Leary | Mike Boddicker | | 51 | 51 | 0 |
| 1991-04-20 | vs KCA | 11 | L 2-5 | 4-7 | 7 | 17,969 | Scott Sanderson | Tom Gordon | Tom Gordon | Scott Sanderson | Jeff Montgomery | 53 | 56 | -3 |
| 1991-04-22 | vs DET | 12 | L 5-10 | 4-8 | 7 | 12,938 | Andy Hawkins | Steve Searcy | Jerry Gleaton | Greg Cadaret | | 58 | 66 | -8 |
| 1991-04-23 | vs DET | 13 | W 5-0 | 5-8 | 6 | 14,789 | Dave Eiland | Frank Tanana | Dave Eiland | Frank Tanana | | 63 | 66 | -3 |
| 1991-04-26 | @ CHA | 14 | W 3-2 | 6-8 | 6 | 30,350 | Tim Leary | Greg Hibbard | Greg Cadaret | Brian Drahman | | 66 | 68 | -2 |
| 1991-04-27 | @ CHA | 15 | L 9-14 | 6-9 | 6 | 34,493 | Scott Sanderson | Melido Perez | Melido Perez | Eric Plunk | | 75 | 82 | -7 |
| 1991-04-28 | @ CHA | 16 | L 1-4 | 6-10 | 7 | 36,242 | Chuck Cary | Jack McDowell | Jack McDowell | Chuck Cary | Bobby Thigpen | 76 | 86 | -10 |
| 1991-04-30 | @ OAK | 17 | L 3-7 | 6-11 | 6 | 40,239 | Dave Eiland | Bob Welch | Bob Welch | Dave Eiland | | 79 | 93 | -14 |
| 1991-05-01 | @ OAK | 18 | L 4-7 | 6-12 | 7 | 36,139 | Tim Leary | Mike Moore | Mike Moore | Tim Leary | Dennis Eckersley | 83 | 100 | -17 |
| 1991-05-03 | @ SEA | 19 | W 5-0 | 7-12 | 7 | 22,884 | Scott Sanderson | Brian Holman | Scott Sanderson | Brian Holman | | 88 | 100 | -12 |
| 1991-05-04 | @ SEA | 20 | L 2-3 | 7-13 | 7 | 53,755 | Chuck Cary | Scott Bankhead | Scott Bankhead | Chuck Cary | Michael Jackson | 90 | 103 | -13 |
| 1991-05-05 | @ SEA | 21 | L 4-5 | 7-14 | 7 | 24,391 | Dave Eiland | Rich DeLucia | Bill Krueger | Rich Monteleone | | 94 | 108 | -14 |
| 1991-05-06 | @ SEA | 22 | L 2-4 | 7-15 | 7 | 24,210 | Tim Leary | Erik Hanson | Erik Hanson | Tim Leary | Bill Swift | 96 | 112 | -16 |
| 1991-05-07 | @ CAL | 23 | L 4-7 | 7-16 | 7 | 24,977 | Andy Hawkins | Chuck Finley | Chuck Finley | Andy Hawkins | Bryan Harvey | 100 | 119 | -19 |
| 1991-05-08 | @ CAL | 24 | W 10-5 | 8-16 | 7 | 26,024 | Scott Sanderson | Kirk McCaskill | Scott Sanderson | Kirk McCaskill | | 110 | 124 | -14 |
| 1991-05-10 | vs OAK | 25 | W 5-3 | 9-16 | 6 | 25,336 | Chuck Cary | Bob Welch | John Habyan | Joe Klink | Steve Farr | 115 | 127 | -12 |
| 1991-05-11 | vs OAK | 26 | L 2-10 | 9-17 | 7 | 30,967 | Dave Eiland | Kirk Dressendorfer | Kirk Dressendorfer | Dave Eiland | | 117 | 137 | -20 |
| 1991-05-12 | vs OAK | 27 | W 10-6 | 10-17 | 6 | 25,212 | Tim Leary | Mike Moore | Steve Farr | Mike Moore | | 127 | 143 | -16 |
| 1991-05-13 | vs OAK | 28 | W 6-3 | 11-17 | 6 | 17,691 | Scott Sanderson | Curt Young | Scott Sanderson | Curt Young | Lee Guetterman | 133 | 146 | -13 |
| 1991-05-14 | vs CAL | 29 | W 7-1 | 12-17 | 5 | 19,211 | Pascual Perez | Kirk McCaskill | Pascual Perez | Kirk McCaskill | John Habyan | 140 | 147 | -7 |
| 1991-05-15 | vs CAL | 30 | L 2-10 | 12-18 | 5 | 16,017 | Chuck Cary | Mark Langston | Mark Langston | Chuck Cary | | 142 | 157 | -15 |
| 1991-05-16 | vs CAL | 31 | L 0-7 | 12-19 | 5 | 14,774 | Dave Eiland | Jim Abbott | Jim Abbott | Eric Plunk | | 142 | 164 | -22 |
| 1991-05-17 | vs SEA | 32 | L 0-1 | 12-20 | 7 | 16,810 | Tim Leary | Randy Johnson | Randy Johnson | Tim Leary | Bill Swift | 142 | 165 | -23 |
| 1991-05-18 | vs SEA | 33 | L 1-4 | 12-21 | 7 | 23,017 | Scott Sanderson | Pat Rice | Pat Rice | Scott Sanderson | | 143 | 169 | -26 |
| 1991-05-19 | vs SEA | 34 | W 3-2 | 13-21 | 5 | 29,581 | Pascual Perez | Brian Holman | Steve Howe | Brian Holman | Lee Guetterman | 146 | 171 | -25 |
| 1991-05-20 | @ CLE | 35 | L 1-3 | 13-22 | 6 | 7,047 | Chuck Cary | Eric King | Eric King | Chuck Cary | Shawn Hillegas | 147 | 174 | -27 |
| 1991-05-21 | @ CLE | 36 | L 2-5 | 13-23 | 7 | 11,683 | Dave Eiland | Greg Swindell | Greg Swindell | Dave Eiland | | 149 | 179 | -30 |
| 1991-05-22 | @ CLE | 37 | W 8-1 | 14-23 | 6 | 10,630 | Tim Leary | Tom Candiotti | Tim Leary | Tom Candiotti | | 157 | 180 | -23 |
| 1991-05-24 | @ BAL | 38 | W 7-1 | 15-23 | 5 | 30,436 | Scott Sanderson | Jeff Robinson | Scott Sanderson | Jeff Robinson | | 164 | 181 | -17 |
| 1991-05-25 | @ BAL | 39 | W 6-5 | 16-23 | 5 | 36,459 | Pascual Perez | Jeff Ballard | Steve Farr | Mike Flanagan | Lee Guetterman | 170 | 186 | -16 |
| 1991-05-26 | @ BAL | 40 | W 2-1 | 17-23 | 5 | 39,259 | Chuck Cary | Jose Mesa | John Habyan | Mike Flanagan | Greg Cadaret | 172 | 187 | -15 |
| 1991-05-27 | vs BOS | 41 | W 6-5 | 18-23 | 5 | 32,369 | Dave Eiland | Danny Darwin | Lee Guetterman | Jeff Reardon | | 178 | 192 | -14 |
| 1991-05-28 | vs BOS | 42 | L 2-6 | 18-24 | 5 | 32,943 | Tim Leary | Roger Clemens | Roger Clemens | Tim Leary | | 180 | 198 | -18 |
| 1991-05-29 | vs BOS | 43 | W 7-0 | 19-24 | 5 | 25,242 | Scott Sanderson | Tom Bolton | Scott Sanderson | Tom Bolton | | 187 | 198 | -11 |
| 1991-05-31 | vs MIL | 44 | W 3-2 | 20-24 | 5 | 19,084 | Pascual Perez | Chris Bosio | Steve Howe | Chuck Crim | | 190 | 200 | -10 |
| 1991-06-01 | vs MIL | 45 | L 3-6 | 20-25 | 5 | 23,599 | Chuck Cary | Bill Wegman | Bill Wegman | Chuck Cary | | 193 | 206 | -13 |
| 1991-06-02 | vs MIL | 46 | W 7-4 | 21-25 | 5 | 30,507 | Wade Taylor | Teddy Higuera | Wade Taylor | Teddy Higuera | Steve Farr | 200 | 210 | -10 |
| 1991-06-03 | vs TOR | 47 | L 3-5 | 21-26 | 5 | 17,003 | Tim Leary | Jimmy Key | Jimmy Key | Tim Leary | Tom Henke | 203 | 215 | -12 |
| 1991-06-04 | vs TOR | 48 | W 5-3 | 22-26 | 5 | 15,955 | Scott Sanderson | Todd Stottlemyre | Scott Sanderson | Todd Stottlemyre | Steve Farr | 208 | 218 | -10 |
| 1991-06-05 | vs TOR | 49 | L 1-4 | 22-27 | 5 | 21,213 | Jeff Johnson | David Wells | David Wells | Jeff Johnson | Tom Henke | 209 | 222 | -13 |
| 1991-06-07 | vs TEX | 50 | W 5-4 | 23-27 | 4 | 21,452 | Mike Witt | Kenny Rogers | John Habyan | John Barfield | | 214 | 226 | -12 |
| 1991-06-08 | vs TEX | 51 | W 10-7 | 24-27 | 4 | 27,969 | Wade Taylor | Mark Petkovsek | Wade Taylor | Mark Petkovsek | Steve Farr | 224 | 233 | -9 |
| 1991-06-09 | vs TEX | 52 | W 6-4 | 25-27 | 4 | 39,014 | Tim Leary | Jose Guzman | John Habyan | Rich Gossage | Steve Farr | 230 | 237 | -7 |
| 1991-06-11 | @ MIN | 53 | L 3-5 | 25-28 | 4 | 18,233 | Scott Sanderson | Kevin Tapani | Kevin Tapani | John Habyan | Rick Aguilera | 233 | 242 | -9 |
| 1991-06-12 | @ MIN | 54 | L 3-6 | 25-29 | 4 | 19,178 | Jeff Johnson | Allan Anderson | Allan Anderson | Jeff Johnson | Steve Bedrosian | 236 | 248 | -12 |
| 1991-06-13 | @ MIN | 55 | L 3-10 | 25-30 | 4 | 29,867 | Mike Witt | Scott Erickson | Scott Erickson | Mike Witt | | 239 | 258 | -19 |
| 1991-06-14 | @ TEX | 56 | L 4-8 | 25-31 | 4 | 32,928 | Wade Taylor | Jose Guzman | Jose Guzman | Wade Taylor | | 243 | 266 | -23 |
| 1991-06-15 | @ TEX | 57 | L 3-4 | 25-32 | 5 | 41,772 | Tim Leary | Kevin Brown | Kevin Brown | Tim Leary | Jeff Russell | 246 | 270 | -24 |
| 1991-06-16 | @ TEX | 58 | L 3-4 | 25-33 | 5 | 37,691 | Scott Sanderson | Nolan Ryan | Joe Bitker | Lee Guetterman | | 249 | 274 | -25 |
| 1991-06-18 | @ TOR | 59 | W 4-2 | 26-33 | 5 | 50,271 | Scott Kamieniecki | Mike Timlin | Scott Kamieniecki | Mike Timlin | Steve Farr | 253 | 276 | -23 |
| 1991-06-19 | @ TOR | 60 | W 3-0 | 27-33 | 5 | 50,281 | Jeff Johnson | Jimmy Key | Jeff Johnson | Jimmy Key | Steve Howe | 256 | 276 | -20 |
| 1991-06-20 | @ TOR | 61 | L 1-6 | 27-34 | 5 | 50,256 | Tim Leary | Todd Stottlemyre | Todd Stottlemyre | Tim Leary | | 257 | 282 | -25 |
| 1991-06-21 | vs MIN | 62 | L 4-5 | 27-35 | 5 | 32,209 | Scott Sanderson | Mark Guthrie | Mark Guthrie | Scott Sanderson | Rick Aguilera | 261 | 287 | -26 |
| 1991-06-22 | vs MIN | 63 | L 3-4 | 27-36 | 5 | 25,352 | Wade Taylor | Kevin Tapani | Kevin Tapani | Wade Taylor | Rick Aguilera | 264 | 291 | -27 |
| 1991-06-23 | vs MIN | 64 | W 11-2 | 28-36 | 5 | 36,952 | Scott Kamieniecki | Allan Anderson | Scott Kamieniecki | Allan Anderson | | 275 | 293 | -18 |
| 1991-06-24 | vs MIN | 65 | L 0-5 | 28-37 | 5 | 23,142 | Jeff Johnson | Scott Erickson | Scott Erickson | Jeff Johnson | | 275 | 298 | -23 |
| 1991-06-25 | @ BOS | 66 | W 6-4 | 29-37 | 5 | 34,753 | Tim Leary | Roger Clemens | Tim Leary | Roger Clemens | Steve Farr | 281 | 302 | -21 |
| 1991-06-26 | @ BOS | 67 | W 5-1 | 30-37 | 5 | 34,514 | Scott Sanderson | Mike Gardiner | Scott Sanderson | Mike Gardiner | Steve Howe | 286 | 303 | -17 |
| 1991-06-27 | @ BOS | 68 | W 8-0 | 31-37 | 5 | 34,529 | Wade Taylor | Tom Bolton | Wade Taylor | Tom Bolton | | 294 | 303 | -9 |
| 1991-06-28 | @ MIL | 69 | L 2-5 | 31-38 | 5 | 19,442 | Scott Kamieniecki | Don August | Don August | Scott Kamieniecki | Dan Plesac | 296 | 308 | -12 |
| 1991-06-29 | @ MIL | 70 | W 9-8 | 32-38 | 5 | 31,992 | Jeff Johnson | Teddy Higuera | Lee Guetterman | Dan Plesac | Steve Farr | 305 | 316 | -11 |
| 1991-06-30 | @ MIL | 71 | W 8-6 | 33-38 | 5 | 27,400 | Tim Leary | Bill Wegman | Greg Cadaret | Mark Lee | Steve Farr | 313 | 322 | -9 |
| 1991-07-01 | vs CLE | 72 | W 6-2 | 34-38 | 4 | 19,720 | Scott Sanderson | Greg Swindell | Scott Sanderson | Greg Swindell | Lee Guetterman | 319 | 324 | -5 |
| 1991-07-02 | vs CLE | 73 | W 8-5 | 35-38 | 4 | 17,636 | Wade Taylor | Mike York | Wade Taylor | Mike York | Steve Farr | 327 | 329 | -2 |
| 1991-07-03 | vs CLE | 74 | W 3-2 | 36-38 | 4 | 18,120 | Scott Kamieniecki | Denis Boucher | Scott Kamieniecki | Denis Boucher | Steve Farr | 330 | 331 | -1 |
| 1991-07-04 | vs BAL | 75 | W 3-2 | 37-38 | 4 | 31,309 | Jeff Johnson | Roy Smith | Eric Plunk | Roy Smith | Lee Guetterman | 333 | 333 | 0 |
| 1991-07-05 | vs BAL | 76 | L 4-7 | 37-39 | 4 | 21,123 | Tim Leary | Jeff Robinson | Jeff Robinson | Tim Leary | Gregg Olson | 337 | 340 | -3 |
| 1991-07-06 | vs BAL | 77 | W 13-5 | 38-39 | 4 | 29,932 | Scott Sanderson | Ben McDonald | Eric Plunk | Todd Frohwirth | | 350 | 345 | 5 |
| 1991-07-07 | vs BAL | 78 | L 3-5 | 38-40 | 4 | 43,505 | Wade Taylor | Jeff Ballard | Jeff Ballard | Wade Taylor | Gregg Olson | 353 | 350 | 3 |
| 1991-07-11 | @ CAL | 79 | W 2-0 | 39-40 | 4 | 31,218 | Scott Sanderson | Kirk McCaskill | Scott Sanderson | Kirk McCaskill | | 355 | 350 | 5 |
| 1991-07-12 | @ CAL | 80 | W 2-1 | 40-40 | 4 | 31,348 | Scott Kamieniecki | Mark Langston | Steve Howe | Bryan Harvey | Steve Farr | 357 | 351 | 6 |
| 1991-07-13 | @ CAL | 81 | W 2-0 | 41-40 | 3 | 37,030 | Jeff Johnson | Jim Abbott | Jeff Johnson | Jim Abbott | Steve Farr | 359 | 351 | 8 |
| 1991-07-14 | @ CAL | 82 | L 2-10 | 41-41 | 4 | 36,150 | Wade Taylor | Chuck Finley | Chuck Finley | Wade Taylor | | 361 | 361 | 0 |
| 1991-07-15 | @ SEA | 83 | L 1-5 | 41-42 | 4 | 36,027 | Greg Cadaret | Bill Krueger | Bill Krueger | Greg Cadaret | | 362 | 366 | -4 |
| 1991-07-16 | @ SEA | 84 | L 0-5 | 41-43 | 4 | 25,641 | Scott Sanderson | Brian Holman | Brian Holman | Scott Sanderson | | 362 | 371 | -9 |
| 1991-07-18 | @ OAK | 85 | W 3-2 | 42-43 | 4 | 39,437 | Scott Kamieniecki | Eric Show | Scott Kamieniecki | Eric Show | Steve Howe | 365 | 373 | -8 |
| 1991-07-19 | @ OAK | 86 | W 3-0 | 43-43 | 4 | 35,537 | Jeff Johnson | Mike Moore | Jeff Johnson | Mike Moore | Steve Farr | 368 | 373 | -5 |
| 1991-07-20 | @ OAK | 87 | W 5-1 | 44-43 | 3 | 44,429 | Wade Taylor | Andy Hawkins | Wade Taylor | Andy Hawkins | | 373 | 374 | -1 |
| 1991-07-21 | @ OAK | 88 | L 2-4 | 44-44 | 3 | 43,007 | Scott Sanderson | Dave Stewart | Dave Stewart | Scott Sanderson | Dennis Eckersley | 375 | 378 | -3 |
| 1991-07-23 | vs SEA | 89 | L 1-6 | 44-45 | 3 | 17,293 | Scott Kamieniecki | Randy Johnson | Randy Johnson | Scott Kamieniecki | | 376 | 384 | -8 |
| 1991-07-24 | vs SEA | 90 | W 10-2 | 45-45 | 3 | 21,585 | Jeff Johnson | Erik Hanson | Jeff Johnson | Erik Hanson | | 386 | 386 | 0 |
| 1991-07-25 | vs SEA | 91 | L 3-6 | 45-46 | 3 | 24,559 | Wade Taylor | Bill Krueger | Bill Krueger | Wade Taylor | Rob Murphy | 389 | 392 | -3 |
| 1991-07-26 | vs CAL | 92 | L 1-5 | 45-47 | 4 | 22,108 | Scott Sanderson | Mark Langston | Mark Langston | Scott Sanderson | Bryan Harvey | 390 | 397 | -7 |
| 1991-07-27 | vs CAL | 93 | W 12-10 | 46-47 | 3 | 45,647 | Greg Cadaret | Mike Fetters | Greg Cadaret | Mike Fetters | Steve Farr | 402 | 407 | -5 |
| 1991-07-28 | vs CAL | 94 | L 4-8 | 46-48 | 3 | 36,303 | Scott Kamieniecki | Jim Abbott | Jim Abbott | Scott Kamieniecki | | 406 | 415 | -9 |
| 1991-07-29 | vs OAK | 95 | L 8-10 | 46-49 | 3 | 30,313 | Jeff Johnson | Eric Show | Kevin Campbell | Steve Howe | Dennis Eckersley | 414 | 425 | -11 |
| 1991-07-30 | vs OAK | 96 | L 5-6 | 46-50 | 3 | 36,803 | Wade Taylor | Andy Hawkins | Curt Young | Wade Taylor | Dennis Eckersley | 419 | 431 | -12 |
| 1991-07-31 | vs MIN | 97 | L 3-12 | 46-51 | 4 | 24,300 | Scott Sanderson | Kevin Tapani | Kevin Tapani | Scott Sanderson | | 422 | 443 | -21 |
| 1991-08-01 | vs MIN | 98 | W 8-3 | 47-51 | 3 | 25,711 | Greg Cadaret | Paul Abbott | Greg Cadaret | Paul Abbott | | 430 | 446 | -16 |
| 1991-08-02 | @ DET | 99 | L 3-7 | 47-52 | 4 | 25,578 | Scott Kamieniecki | Frank Tanana | Frank Tanana | Scott Kamieniecki | | 433 | 453 | -20 |
| 1991-08-03 | @ DET | 100 | L 6-7 | 47-53 | 4 | 30,927 | Jeff Johnson | Bill Gullickson | Bill Gullickson | Jeff Johnson | Mike Henneman | 439 | 460 | -21 |
| 1991-08-04 | @ DET | 101 | L 7-8 | 47-54 | 4 | 30,022 | Wade Taylor | Scott Aldred | Mike Henneman | Steve Farr | | 446 | 468 | -22 |
| 1991-08-05 | @ DET | 102 | W 7-5 | 48-54 | 4 | 25,938 | Scott Sanderson | Walt Terrell | Scott Sanderson | Walt Terrell | Lee Guetterman | 453 | 473 | -20 |
| 1991-08-06 | @ CHA | 103 | L 5-14 | 48-55 | 4 | 37,355 | Greg Cadaret | Ramon Garcia | Donn Pall | Tim Leary | | 458 | 487 | -29 |
| 1991-08-07 | @ CHA | 104 | L 2-10 | 48-56 | 4 | 41,870 | Dave Eiland | Jack McDowell | Jack McDowell | Dave Eiland | | 460 | 497 | -37 |
| 1991-08-08 | @ CHA | 105 | L 1-4 | 48-57 | 4 | 36,032 | Jeff Johnson | Alex Fernandez | Alex Fernandez | Jeff Johnson | Scott Radinsky | 461 | 501 | -40 |
| 1991-08-10 | vs DET | 106 | L 1-5 | 48-59 | 4 | 0 | Scott Sanderson | Mark Leiter | Mark Leiter | Scott Sanderson | | 462 | 506 | -44 |
| 1991-08-10 | vs DET | 107 | L 0-4 | 48-59 | 4 | 28,744 | Wade Taylor | Walt Terrell | Walt Terrell | Wade Taylor | | 462 | 510 | -48 |
| 1991-08-11 | vs DET | 108 | W 12-6 | 50-59 | 4 | 0 | Greg Cadaret | John Cerutti | Greg Cadaret | Dan Gakeler | | 474 | 516 | -42 |
| 1991-08-11 | vs DET | 109 | W 10-8 | 50-59 | 4 | 34,733 | Tim Leary | Scott Aldred | Steve Farr | Paul Gibson | | 484 | 524 | -40 |
| 1991-08-13 | vs KCA | 110 | L 0-5 | 50-61 | 5 | 0 | Jeff Johnson | Kevin Appier | Kevin Appier | Jeff Johnson | | 484 | 529 | -45 |
| 1991-08-13 | vs KCA | 111 | L 1-8 | 50-61 | 5 | 24,031 | Dave Eiland | Mike Boddicker | Mike Boddicker | Dave Eiland | Jeff Montgomery | 485 | 537 | -52 |
| 1991-08-14 | vs KCA | 112 | L 1-5 | 50-62 | 5 | 18,780 | Eric Plunk | Mark Davis | Tom Gordon | Steve Farr | | 486 | 542 | -56 |
| 1991-08-15 | vs KCA | 113 | W 5-1 | 51-62 | 5 | 20,758 | Scott Sanderson | Mark Gubicza | Scott Sanderson | Mark Gubicza | | 491 | 543 | -52 |
| 1991-08-16 | vs CHA | 114 | W 6-5 | 52-62 | 5 | 23,172 | Pascual Perez | Wilson Alvarez | Rich Monteleone | Scott Radinsky | | 497 | 548 | -51 |
| 1991-08-17 | vs CHA | 115 | W 4-2 | 53-62 | 5 | 27,252 | Wade Taylor | Jack McDowell | Wade Taylor | Jack McDowell | Steve Farr | 501 | 550 | -49 |
| 1991-08-18 | vs CHA | 116 | L 3-11 | 53-63 | 5 | 34,771 | Jeff Johnson | Greg Hibbard | Greg Hibbard | Jeff Johnson | | 504 | 561 | -57 |
| 1991-08-19 | @ KCA | 117 | W 6-2 | 54-63 | 5 | 39,011 | Eric Plunk | Mike Boddicker | Greg Cadaret | Mike Boddicker | | 510 | 563 | -53 |
| 1991-08-20 | @ KCA | 118 | W 7-3 | 55-63 | 4 | 24,031 | Scott Sanderson | Mark Gubicza | Scott Sanderson | Mark Gubicza | | 517 | 566 | -49 |
| 1991-08-21 | @ KCA | 119 | L 4-7 | 55-64 | 5 | 24,213 | Pascual Perez | Bret Saberhagen | Bret Saberhagen | Pascual Perez | | 521 | 573 | -52 |
| 1991-08-23 | @ TOR | 120 | L 5-6 | 55-65 | 5 | 50,318 | Wade Taylor | Tom Candiotti | Duane Ward | Steve Farr | | 526 | 579 | -53 |
| 1991-08-24 | @ TOR | 121 | W 6-5 | 56-65 | 5 | 50,324 | Jeff Johnson | David Wells | Jeff Johnson | David Wells | Greg Cadaret | 532 | 584 | -52 |
| 1991-08-25 | @ TOR | 122 | L 7-11 | 56-66 | 5 | 50,320 | Scott Sanderson | Todd Stottlemyre | Jim Acker | Lee Guetterman | | 539 | 595 | -56 |
| 1991-08-26 | vs TEX | 123 | L 2-10 | 56-67 | 5 | 17,149 | Eric Plunk | Kevin Brown | Kevin Brown | Eric Plunk | | 541 | 605 | -64 |
| 1991-08-27 | vs TEX | 124 | L 2-7 | 56-68 | 5 | 23,498 | Pascual Perez | Jose Guzman | Jose Guzman | Pascual Perez | Kenny Rogers | 543 | 612 | -69 |
| 1991-08-28 | vs TEX | 125 | W 5-1 | 57-68 | 5 | 20,657 | Wade Taylor | Brian Bohanon | Wade Taylor | Brian Bohanon | | 548 | 613 | -65 |
| 1991-08-29 | vs TOR | 126 | L 2-6 | 57-69 | 5 | 19,344 | Jeff Johnson | David Wells | David Wells | Jeff Johnson | | 550 | 619 | -69 |
| 1991-08-30 | vs TOR | 127 | W 9-2 | 58-69 | 5 | 19,393 | Scott Sanderson | Todd Stottlemyre | Scott Sanderson | Todd Stottlemyre | | 559 | 621 | -62 |
| 1991-08-31 | vs TOR | 128 | L 0-5 | 58-70 | 5 | 28,932 | Eric Plunk | Jimmy Key | Jimmy Key | Greg Cadaret | Duane Ward | 559 | 626 | -67 |
| 1991-09-01 | vs TOR | 129 | W 4-2 | 59-70 | 5 | 25,105 | Pascual Perez | Juan Guzman | Lee Guetterman | Bob Macdonald | | 563 | 628 | -65 |
| 1991-09-02 | @ TEX | 130 | L 2-7 | 59-71 | 5 | 27,657 | Wade Taylor | Oil Can Boyd | Oil Can Boyd | Tim Leary | | 565 | 635 | -70 |
| 1991-09-03 | @ TEX | 131 | L 1-5 | 59-72 | 5 | 12,909 | Jeff Johnson | Jose Guzman | Jose Guzman | Jeff Johnson | | 566 | 640 | -74 |
| 1991-09-04 | @ TEX | 132 | W 3-2 | 60-72 | 5 | 14,861 | Scott Sanderson | Brian Bohanon | Greg Cadaret | Brian Bohanon | Steve Farr | 569 | 642 | -73 |
| 1991-09-06 | @ MIN | 133 | L 1-3 | 60-73 | 5 | 27,804 | Wade Taylor | Kevin Tapani | Kevin Tapani | Wade Taylor | Rick Aguilera | 570 | 645 | -75 |
| 1991-09-07 | @ MIN | 134 | L 2-3 | 60-74 | 5 | 35,504 | Pascual Perez | Jack Morris | Carl Willis | Lee Guetterman | | 572 | 648 | -76 |
| 1991-09-08 | @ MIN | 135 | L 5-6 | 60-75 | 5 | 27,281 | Jeff Johnson | Scott Erickson | Scott Erickson | Jeff Johnson | Steve Bedrosian | 577 | 654 | -77 |
| 1991-09-09 | @ BAL | 136 | L 0-8 | 60-76 | 5 | 22,792 | Scott Sanderson | Bob Milacki | Bob Milacki | Scott Sanderson | | 577 | 662 | -85 |
| 1991-09-10 | @ BAL | 137 | L 3-6 | 60-77 | 5 | 22,551 | Eric Plunk | Arthur Rhodes | Todd Frohwirth | Eric Plunk | | 580 | 668 | -88 |
| 1991-09-11 | @ BAL | 138 | L 2-4 | 60-78 | 5 | 44,847 | Wade Taylor | Mike Mussina | Mike Mussina | Wade Taylor | Gregg Olson | 582 | 672 | -90 |
| 1991-09-12 | vs BOS | 139 | L 2-7 | 60-79 | 5 | 19,312 | Pascual Perez | Kevin Morton | Kevin Morton | Pascual Perez | | 584 | 679 | -95 |
| 1991-09-13 | vs BOS | 140 | L 4-5 | 60-80 | 5 | 27,831 | Jeff Johnson | Mike Gardiner | Mike Gardiner | Jeff Johnson | Jeff Reardon | 588 | 684 | -96 |
| 1991-09-14 | vs BOS | 141 | W 3-1 | 61-80 | 5 | 45,758 | Scott Sanderson | Joe Hesketh | Scott Sanderson | Joe Hesketh | Steve Farr | 591 | 685 | -94 |
| 1991-09-15 | vs BOS | 142 | L 4-5 | 61-81 | 5 | 22,303 | Eric Plunk | Roger Clemens | Roger Clemens | Lee Guetterman | Jeff Reardon | 595 | 690 | -95 |
| 1991-09-16 | vs MIL | 143 | L 4-5 | 61-82 | 5 | 17,751 | Wade Taylor | Don August | Mark Lee | Wade Taylor | Doug Henry | 599 | 695 | -96 |
| 1991-09-17 | vs MIL | 144 | L 0-2 | 61-83 | 5 | 12,575 | Pascual Perez | Chris Bosio | Chris Bosio | Pascual Perez | | 599 | 697 | -98 |
| 1991-09-18 | vs MIL | 145 | W 2-1 | 62-83 | 5 | 13,160 | Jeff Johnson | Jaime Navarro | Steve Farr | Jaime Navarro | | 601 | 698 | -97 |
| 1991-09-20 | @ BOS | 146 | L 0-2 | 62-84 | 5 | 34,535 | Scott Sanderson | Roger Clemens | Roger Clemens | Scott Sanderson | | 601 | 700 | -99 |
| 1991-09-21 | @ BOS | 147 | L 1-12 | 62-85 | 5 | 34,520 | Wade Taylor | Joe Hesketh | Joe Hesketh | Wade Taylor | | 602 | 712 | -110 |
| 1991-09-22 | @ BOS | 148 | W 7-5 | 63-85 | 5 | 34,514 | Pascual Perez | Kevin Morton | Steve Farr | Matt Young | | 609 | 717 | -108 |
| 1991-09-23 | @ MIL | 149 | W 9-8 | 64-85 | 5 | 8,193 | Jeff Johnson | Jaime Navarro | Rich Monteleone | Mark Lee | Steve Farr | 618 | 725 | -107 |
| 1991-09-24 | @ MIL | 150 | L 4-5 | 64-86 | 5 | 9,378 | Eric Plunk | Cal Eldred | Cal Eldred | Eric Plunk | Doug Henry | 622 | 730 | -108 |
| 1991-09-25 | @ MIL | 151 | W 8-6 | 65-86 | 5 | 7,691 | Scott Sanderson | Dan Plesac | Alan Mills | Don August | | 630 | 736 | -106 |
| 1991-09-26 | @ MIL | 152 | L 2-6 | 65-87 | 5 | 9,841 | Wade Taylor | Bill Wegman | Bill Wegman | Wade Taylor | | 632 | 742 | -110 |
| 1991-09-27 | @ CLE | 153 | W 3-0 | 66-87 | 5 | 6,163 | Pascual Perez | Greg Swindell | Pascual Perez | Greg Swindell | Steve Farr | 635 | 742 | -107 |
| 1991-09-28 | @ CLE | 154 | L 4-5 | 66-88 | 5 | 8,555 | Jeff Johnson | Shawn Hillegas | Eric Bell | Greg Cadaret | Steve Olin | 639 | 747 | -108 |
| 1991-09-29 | @ CLE | 155 | L 2-5 | 66-89 | 6 | 13,006 | Alan Mills | Eric King | Eric King | Alan Mills | Steve Olin | 641 | 752 | -111 |
| 1991-09-30 | @ CLE | 156 | W 3-0 | 67-89 | 5 | 4,145 | Scott Sanderson | Charles Nagy | Scott Sanderson | Charles Nagy | Greg Cadaret | 644 | 752 | -108 |
| 1991-10-01 | vs BAL | 157 | W 3-2 | 68-89 | 5 | 12,991 | Dave Eiland | Bob Milacki | Rich Monteleone | Jim Poole | | 647 | 754 | -107 |
| 1991-10-02 | vs BAL | 158 | W 4-3 | 69-89 | 5 | 12,088 | Pascual Perez | Arthur Rhodes | Greg Cadaret | Mike Flanagan | Steve Farr | 651 | 757 | -106 |
| 1991-10-03 | vs BAL | 159 | W 9-6 | 70-89 | 5 | 12,772 | Jeff Johnson | Jeff Ballard | Jeff Johnson | Jeff Ballard | Steve Farr | 660 | 763 | -103 |
| 1991-10-04 | vs CLE | 160 | L 2-3 | 70-90 | 5 | 14,627 | Alan Mills | Shawn Hillegas | Eric Bell | Steve Farr | Steve Olin | 662 | 766 | -104 |
| 1991-10-05 | vs CLE | 161 | L 5-7 | 70-91 | 5 | 15,681 | Eric Plunk | Eric King | Steve Olin | Darrin Chapin | Doug Jones | 667 | 773 | -106 |
| 1991-10-06 | vs CLE | 162 | W 7-4 | 71-91 | 5 | 17,863 | Dave Eiland | Charles Nagy | Dave Eiland | Charles Nagy | John Habyan | 674 | 777 | -103 |