| 1991-04-08 | vs PHI | 1 | W 2-1 | 1-0 | 2 | 49,276 | Dwight Gooden | Terry Mulholland | Dwight Gooden | Terry Mulholland | John Franco | 2 | 1 | 1 |
| 1991-04-09 | vs PHI | 2 | W 2-1 | 2-0 | 1 | 16,013 | Frank Viola | Jason Grimsley | Doug Simons | Joe Boever | | 4 | 2 | 2 |
| 1991-04-10 | vs PHI | 3 | L 7-8 | 2-1 | 1 | 22,841 | David Cone | Jose De Jesus | Roger McDowell | Jeff Innis | Mitch Williams | 11 | 10 | 1 |
| 1991-04-11 | vs MON | 4 | W 6-3 | 3-1 | 1 | 17,271 | Wally Whitehurst | Rick Mahler | Wally Whitehurst | Rick Mahler | John Franco | 17 | 13 | 4 |
| 1991-04-12 | vs MON | 5 | L 3-4 | 3-2 | 2 | 22,163 | Ron Darling | Bill Sampen | Tim Burke | John Franco | Steve Frey | 20 | 17 | 3 |
| 1991-04-13 | vs MON | 6 | W 5-3 | 4-2 | 1 | 26,046 | Dwight Gooden | Dennis Martinez | Dwight Gooden | Dennis Martinez | | 25 | 20 | 5 |
| 1991-04-14 | vs MON | 7 | W 7-1 | 5-2 | 1 | 25,944 | Frank Viola | Chris Nabholz | Frank Viola | Chris Nabholz | | 32 | 21 | 11 |
| 1991-04-15 | @ PIT | 8 | W 9-3 | 6-2 | 1 | 6,785 | David Cone | Zane Smith | David Cone | Bob Kipper | | 41 | 24 | 17 |
| 1991-04-16 | @ PIT | 9 | L 2-4 | 6-3 | 1 | 16,963 | Wally Whitehurst | Randy Tomlin | Randy Tomlin | Wally Whitehurst | Stan Belinda | 43 | 28 | 15 |
| 1991-04-17 | @ PIT | 10 | L 0-4 | 6-4 | 2 | 14,792 | Ron Darling | John Smiley | John Smiley | Ron Darling | | 43 | 32 | 11 |
| 1991-04-19 | @ MON | 11 | L 1-2 | 6-5 | 2 | 13,986 | Dwight Gooden | Dennis Martinez | Dennis Martinez | Dwight Gooden | Tim Burke | 44 | 34 | 10 |
| 1991-04-20 | @ MON | 12 | W 3-1 | 7-5 | 2 | 19,444 | Frank Viola | Chris Nabholz | Frank Viola | Chris Nabholz | John Franco | 47 | 35 | 12 |
| 1991-04-21 | @ MON | 13 | W 9-5 | 8-5 | 1 | 8,409 | David Cone | Oil Can Boyd | David Cone | Oil Can Boyd | Pete Schourek | 56 | 40 | 16 |
| 1991-04-23 | @ PHI | 14 | W 2-1 | 9-5 | 1 | 20,187 | Ron Darling | Jason Grimsley | Ron Darling | Jason Grimsley | John Franco | 58 | 41 | 17 |
| 1991-04-24 | @ PHI | 15 | W 7-3 | 10-5 | 1 | 15,214 | Wally Whitehurst | Terry Mulholland | Pete Schourek | Darrel Akerfelds | | 65 | 44 | 21 |
| 1991-04-25 | @ PHI | 16 | L 3-5 | 10-6 | 2 | 22,099 | Dwight Gooden | Pat Combs | Roger McDowell | Doug Simons | Mitch Williams | 68 | 49 | 19 |
| 1991-04-26 | vs PIT | 17 | W 2-0 | 11-6 | 1 | 30,702 | Frank Viola | Zane Smith | Frank Viola | Zane Smith | John Franco | 70 | 49 | 21 |
| 1991-04-27 | vs PIT | 18 | L 1-10 | 11-7 | 2 | 32,062 | David Cone | Randy Tomlin | Randy Tomlin | David Cone | | 71 | 59 | 12 |
| 1991-04-28 | vs PIT | 19 | L 3-7 | 11-8 | 2 | 34,141 | Ron Darling | John Smiley | John Smiley | Ron Darling | | 74 | 66 | 8 |
| 1991-04-30 | vs SDN | 20 | W 6-3 | 12-8 | 3 | 17,059 | Dwight Gooden | Derek Lilliquist | Dwight Gooden | Derek Lilliquist | Alejandro Pena | 80 | 69 | 11 |
| 1991-05-01 | vs SDN | 21 | L 7-8 | 12-9 | 3 | 19,952 | Frank Viola | Bruce Hurst | Bruce Hurst | Frank Viola | Craig Lefferts | 87 | 77 | 10 |
| 1991-05-03 | vs SFN | 22 | W 3-0 | 13-9 | 3 | 28,055 | David Cone | Kelly Downs | David Cone | Kelly Downs | John Franco | 90 | 77 | 13 |
| 1991-05-04 | vs SFN | 23 | W 6-4 | 14-9 | 2 | 38,413 | Ron Darling | John Burkett | Pete Schourek | Mike LaCoss | | 96 | 81 | 15 |
| 1991-05-05 | vs SFN | 24 | L 0-2 | 14-10 | 2 | 42,576 | Dwight Gooden | Buddy Black | Buddy Black | Dwight Gooden | | 96 | 83 | 13 |
| 1991-05-07 | vs LAN | 25 | W 6-5 | 15-10 | 2 | 47,744 | Frank Viola | Tim Belcher | Frank Viola | Tim Belcher | John Franco | 102 | 88 | 14 |
| 1991-05-08 | vs LAN | 26 | L 1-3 | 15-11 | 2 | 40,924 | David Cone | Ramon Martinez | Ramon Martinez | Doug Simons | Jay Howell | 103 | 91 | 12 |
| 1991-05-10 | @ SFN | 27 | L 0-7 | 15-12 | 2 | 21,791 | Dwight Gooden | Buddy Black | Buddy Black | Dwight Gooden | | 103 | 98 | 5 |
| 1991-05-11 | @ SFN | 28 | W 6-2 | 16-12 | 2 | 29,006 | Ron Darling | Don Robinson | Ron Darling | Don Robinson | Alejandro Pena | 109 | 100 | 9 |
| 1991-05-12 | @ SFN | 29 | W 4-2 | 17-12 | 2 | 38,046 | Frank Viola | Trevor Wilson | John Franco | Dave Righetti | | 113 | 102 | 11 |
| 1991-05-13 | @ SDN | 30 | L 2-5 | 17-13 | 2 | 14,158 | David Cone | Andy Benes | Andy Benes | David Cone | Craig Lefferts | 115 | 107 | 8 |
| 1991-05-14 | @ SDN | 31 | W 6-1 | 18-13 | 2 | 24,389 | Wally Whitehurst | Eric Nolte | Wally Whitehurst | Eric Nolte | Pete Schourek | 121 | 108 | 13 |
| 1991-05-15 | @ SDN | 32 | W 7-1 | 19-13 | 2 | 24,858 | Dwight Gooden | Ed Whitson | Dwight Gooden | Ed Whitson | | 128 | 109 | 19 |
| 1991-05-17 | @ LAN | 33 | W 4-2 | 20-13 | 2 | 47,974 | Frank Viola | Mike Morgan | Frank Viola | Mike Morgan | | 132 | 111 | 21 |
| 1991-05-18 | @ LAN | 34 | L 3-4 | 20-14 | 2 | 38,657 | Ron Darling | Tim Belcher | Tim Crews | John Franco | Jay Howell | 135 | 115 | 20 |
| 1991-05-19 | @ LAN | 35 | L 5-7 | 20-15 | 2 | 46,714 | David Cone | Ramon Martinez | Ramon Martinez | David Cone | Tim Crews | 140 | 122 | 18 |
| 1991-05-21 | vs CHN | 36 | W 8-6 | 21-15 | 2 | 29,129 | Dwight Gooden | Rick Sutcliffe | Dwight Gooden | Rick Sutcliffe | John Franco | 148 | 128 | 20 |
| 1991-05-22 | vs CHN | 37 | L 2-5 | 21-16 | 2 | 28,749 | Frank Viola | Greg Maddux | Greg Maddux | Frank Viola | | 150 | 133 | 17 |
| 1991-05-23 | vs CHN | 38 | L 3-4 | 21-17 | 3 | 29,763 | Ron Darling | Shawn Boskie | Les Lancaster | John Franco | Paul Assenmacher | 153 | 137 | 16 |
| 1991-05-24 | vs SLN | 39 | W 6-2 | 22-17 | 2 | 30,795 | David Cone | Bryn Smith | David Cone | Bryn Smith | | 159 | 139 | 20 |
| 1991-05-25 | vs SLN | 40 | L 2-7 | 22-18 | 3 | 39,113 | Wally Whitehurst | Ken Hill | Ken Hill | Wally Whitehurst | | 161 | 146 | 15 |
| 1991-05-26 | vs SLN | 41 | L 4-14 | 22-19 | 3 | 36,254 | Dwight Gooden | Omar Olivares | Cris Carpenter | Dwight Gooden | | 165 | 160 | 5 |
| 1991-05-27 | @ CHN | 42 | W 3-1 | 23-19 | 3 | 33,897 | Frank Viola | Greg Maddux | Frank Viola | Greg Maddux | John Franco | 168 | 161 | 7 |
| 1991-05-28 | @ CHN | 43 | W 9-8 | 24-19 | 2 | 32,811 | Ron Darling | Shawn Boskie | Alejandro Pena | Paul Assenmacher | John Franco | 177 | 169 | 8 |
| 1991-05-29 | @ CHN | 44 | W 8-1 | 25-19 | 2 | 31,359 | David Cone | Bob Scanlan | David Cone | Bob Scanlan | | 185 | 170 | 15 |
| 1991-05-31 | @ SLN | 45 | W 10-5 | 26-19 | 2 | 38,473 | Dwight Gooden | Ken Hill | Wally Whitehurst | Juan Agosto | | 195 | 175 | 20 |
| 1991-06-01 | @ SLN | 46 | L 5-6 | 26-20 | 2 | 40,839 | Frank Viola | Omar Olivares | Juan Agosto | John Franco | | 200 | 181 | 19 |
| 1991-06-02 | @ SLN | 47 | L 1-3 | 26-21 | 2 | 33,241 | Ron Darling | Bob Tewksbury | Bob Tewksbury | Ron Darling | Lee Smith | 201 | 184 | 17 |
| 1991-06-04 | @ CIN | 48 | W 4-2 | 27-21 | 2 | 24,670 | David Cone | Chris Hammond | David Cone | Chris Hammond | John Franco | 205 | 186 | 19 |
| 1991-06-05 | @ CIN | 49 | L 10-11 | 27-22 | 2 | 22,859 | Dwight Gooden | Tom Browning | Tom Browning | Dwight Gooden | Rob Dibble | 215 | 197 | 18 |
| 1991-06-06 | @ CIN | 50 | L 3-5 | 27-23 | 2 | 27,667 | Frank Viola | Jose Rijo | Ted Power | Frank Viola | Randy Myers | 218 | 202 | 16 |
| 1991-06-07 | @ HOU | 51 | W 6-3 | 28-23 | 2 | 15,527 | Ron Darling | Jim Deshaies | Doug Simons | Curt Schilling | | 224 | 205 | 19 |
| 1991-06-08 | @ HOU | 52 | W 4-3 | 29-23 | 2 | 19,462 | Wally Whitehurst | Darryl Kile | Alejandro Pena | Mike Capel | John Franco | 228 | 208 | 20 |
| 1991-06-09 | @ HOU | 53 | L 0-1 | 29-24 | 2 | 21,073 | David Cone | Pete Harnisch | Pete Harnisch | David Cone | | 228 | 209 | 19 |
| 1991-06-10 | @ HOU | 54 | L 4-6 | 29-25 | 2 | 11,809 | Dwight Gooden | Jimmy Jones | Curt Schilling | John Franco | Mike Capel | 232 | 215 | 17 |
| 1991-06-11 | vs ATL | 55 | W 2-1 | 30-25 | 2 | 23,395 | Frank Viola | Charlie Leibrandt | Frank Viola | Charlie Leibrandt | John Franco | 234 | 216 | 18 |
| 1991-06-12 | vs ATL | 56 | L 1-6 | 30-26 | 2 | 20,815 | Ron Darling | Steve Avery | Steve Avery | Ron Darling | | 235 | 222 | 13 |
| 1991-06-13 | vs ATL | 57 | L 2-3 | 30-27 | 3 | 26,211 | Wally Whitehurst | Pete Smith | Pete Smith | Wally Whitehurst | Juan Berenguer | 237 | 225 | 12 |
| 1991-06-14 | vs HOU | 58 | L 1-4 | 30-28 | 3 | 35,497 | David Cone | Pete Harnisch | Mike Capel | John Franco | Jim Clancy | 238 | 229 | 9 |
| 1991-06-15 | vs HOU | 59 | W 6-0 | 31-28 | 3 | 41,709 | Dwight Gooden | Jimmy Jones | Dwight Gooden | Jimmy Jones | | 244 | 229 | 15 |
| 1991-06-16 | vs HOU | 60 | L 4-5 | 31-29 | 3 | 37,550 | Frank Viola | Mark Portugal | Mark Portugal | Frank Viola | Al Osuna | 248 | 234 | 14 |
| 1991-06-17 | vs CIN | 61 | W 10-6 | 32-29 | 3 | 29,892 | Ron Darling | Scott Scudder | Ron Darling | Scott Scudder | | 258 | 240 | 18 |
| 1991-06-18 | vs CIN | 62 | W 7-5 | 33-29 | 3 | 21,058 | Wally Whitehurst | Tom Browning | Alejandro Pena | Randy Myers | | 265 | 245 | 20 |
| 1991-06-19 | vs CIN | 63 | L 6-7 | 33-30 | 3 | 22,206 | David Cone | Chris Hammond | Kip Gross | David Cone | Rob Dibble | 271 | 252 | 19 |
| 1991-06-20 | @ ATL | 64 | W 9-7 | 34-30 | 3 | 29,438 | Dwight Gooden | John Smoltz | Dwight Gooden | John Smoltz | Alejandro Pena | 280 | 259 | 21 |
| 1991-06-21 | @ ATL | 65 | L 2-4 | 34-31 | 3 | 43,229 | Frank Viola | Charlie Leibrandt | Charlie Leibrandt | Frank Viola | Juan Berenguer | 282 | 263 | 19 |
| 1991-06-22 | @ ATL | 66 | W 7-2 | 35-31 | 3 | 43,349 | Ron Darling | Steve Avery | Ron Darling | Steve Avery | | 289 | 265 | 24 |
| 1991-06-23 | @ ATL | 67 | L 3-4 | 35-32 | 3 | 27,561 | Wally Whitehurst | Pete Smith | Kent Mercker | Wally Whitehurst | Juan Berenguer | 292 | 269 | 23 |
| 1991-06-25 | vs MON | 68 | W 8-5 | 36-32 | 3 | 28,809 | Dwight Gooden | Dennis Martinez | Alejandro Pena | Barry Jones | | 300 | 274 | 26 |
| 1991-06-26 | vs MON | 69 | W 7-4 | 37-32 | 3 | 27,662 | Frank Viola | Mark Gardner | Frank Viola | Mark Gardner | John Franco | 307 | 278 | 29 |
| 1991-06-27 | vs MON | 70 | W 4-3 | 38-32 | 3 | 29,302 | David Cone | Oil Can Boyd | David Cone | Oil Can Boyd | John Franco | 311 | 281 | 30 |
| 1991-06-28 | vs PHI | 71 | L 2-6 | 38-33 | 3 | 33,511 | Ron Darling | Jose De Jesus | Jose De Jesus | Ron Darling | | 313 | 287 | 26 |
| 1991-06-29 | vs PHI | 72 | W 5-0 | 39-33 | 3 | 46,244 | Wally Whitehurst | Terry Mulholland | Wally Whitehurst | Terry Mulholland | | 318 | 287 | 31 |
| 1991-06-30 | vs PHI | 73 | L 9-10 | 39-34 | 3 | 44,310 | Dwight Gooden | Danny Cox | Danny Cox | Dwight Gooden | Mitch Williams | 327 | 297 | 30 |
| 1991-07-01 | @ MON | 74 | W 4-2 | 40-34 | 3 | 21,463 | Frank Viola | Mark Gardner | Frank Viola | Mark Gardner | John Franco | 331 | 299 | 32 |
| 1991-07-02 | @ MON | 75 | W 2-1 | 41-34 | 3 | 12,468 | David Cone | Oil Can Boyd | Alejandro Pena | Barry Jones | John Franco | 333 | 300 | 33 |
| 1991-07-03 | @ MON | 76 | W 4-0 | 42-34 | 3 | 13,830 | Ron Darling | Chris Haney | Ron Darling | Chris Haney | | 337 | 300 | 37 |
| 1991-07-04 | @ MON | 77 | W 5-1 | 43-34 | 2 | 12,763 | Wally Whitehurst | Brian Barnes | Wally Whitehurst | Tim Burke | | 342 | 301 | 41 |
| 1991-07-05 | @ PHI | 78 | W 3-1 | 44-34 | 2 | 51,314 | Dwight Gooden | Danny Cox | Dwight Gooden | Danny Cox | John Franco | 345 | 302 | 43 |
| 1991-07-06 | @ PHI | 79 | W 2-1 | 45-34 | 2 | 35,067 | Frank Viola | Bruce Ruffin | Frank Viola | Bruce Ruffin | John Franco | 347 | 303 | 44 |
| 1991-07-07 | @ PHI | 80 | W 8-2 | 46-34 | 2 | 35,444 | David Cone | Tommy Greene | David Cone | Tommy Greene | | 355 | 305 | 50 |
| 1991-07-11 | vs SDN | 81 | W 4-3 | 47-34 | 2 | 32,208 | Dwight Gooden | Bruce Hurst | John Franco | Larry Andersen | | 359 | 308 | 51 |
| 1991-07-12 | vs SDN | 82 | W 6-3 | 48-34 | 2 | 30,706 | Frank Viola | Adam Peterson | Frank Viola | Adam Peterson | Alejandro Pena | 365 | 311 | 54 |
| 1991-07-13 | vs SDN | 83 | W 3-1 | 49-34 | 2 | 33,149 | David Cone | Dennis Rasmussen | David Cone | Dennis Rasmussen | John Franco | 368 | 312 | 56 |
| 1991-07-14 | vs SDN | 84 | L 1-2 | 49-35 | 2 | 46,836 | Ron Darling | Greg Harris | Greg Harris | Ron Darling | Craig Lefferts | 369 | 314 | 55 |
| 1991-07-15 | vs SFN | 85 | L 3-4 | 49-36 | 2 | 28,531 | Wally Whitehurst | Don Robinson | Don Robinson | Wally Whitehurst | Jeff Brantley | 372 | 318 | 54 |
| 1991-07-16 | vs SFN | 86 | W 6-4 | 50-36 | 2 | 33,250 | Dwight Gooden | Trevor Wilson | Dwight Gooden | Trevor Wilson | John Franco | 378 | 322 | 56 |
| 1991-07-17 | vs SFN | 87 | W 6-5 | 51-36 | 2 | 35,731 | Frank Viola | Buddy Black | Alejandro Pena | Dave Righetti | | 384 | 327 | 57 |
| 1991-07-18 | vs LAN | 88 | L 5-10 | 51-37 | 2 | 48,475 | David Cone | Tim Belcher | Kevin Gross | David Cone | | 389 | 337 | 52 |
| 1991-07-19 | vs LAN | 89 | W 6-2 | 52-37 | 2 | 46,711 | Sid Fernandez | Ramon Martinez | Tim Burke | Ramon Martinez | | 395 | 339 | 56 |
| 1991-07-20 | vs LAN | 90 | L 7-11 | 52-38 | 2 | 41,608 | Wally Whitehurst | Orel Hershiser | Jim Gott | Wally Whitehurst | | 402 | 350 | 52 |
| 1991-07-21 | vs LAN | 91 | W 9-4 | 53-38 | 2 | 43,204 | Dwight Gooden | Bob Ojeda | Dwight Gooden | Bob Ojeda | | 411 | 354 | 57 |
| 1991-07-23 | @ SFN | 92 | L 2-4 | 53-39 | 2 | 18,346 | Frank Viola | Buddy Black | Buddy Black | Frank Viola | Dave Righetti | 413 | 358 | 55 |
| 1991-07-24 | @ SFN | 93 | L 4-8 | 53-40 | 2 | 18,809 | David Cone | John Burkett | John Burkett | David Cone | | 417 | 366 | 51 |
| 1991-07-25 | @ SFN | 94 | L 1-8 | 53-41 | 2 | 28,992 | Wally Whitehurst | Trevor Wilson | Trevor Wilson | Wally Whitehurst | | 418 | 374 | 44 |
| 1991-07-26 | @ SDN | 95 | L 2-8 | 53-42 | 2 | 21,880 | Sid Fernandez | Bruce Hurst | Bruce Hurst | Sid Fernandez | | 420 | 382 | 38 |
| 1991-07-27 | @ SDN | 96 | W 4-0 | 54-42 | 2 | 31,304 | Dwight Gooden | Adam Peterson | Dwight Gooden | Adam Peterson | | 424 | 382 | 42 |
| 1991-07-28 | @ SDN | 97 | L 0-2 | 54-43 | 2 | 25,090 | Frank Viola | Andy Benes | Andy Benes | Frank Viola | Craig Lefferts | 424 | 384 | 40 |
| 1991-07-29 | @ LAN | 98 | W 5-1 | 55-43 | 2 | 43,093 | David Cone | Tim Belcher | David Cone | Tim Belcher | | 429 | 385 | 44 |
| 1991-07-30 | @ LAN | 99 | L 1-3 | 55-44 | 2 | 44,559 | Pete Schourek | Ramon Martinez | Ramon Martinez | Pete Schourek | | 430 | 388 | 42 |
| 1991-07-31 | @ LAN | 100 | L 3-6 | 55-45 | 2 | 47,204 | Sid Fernandez | Orel Hershiser | Kevin Gross | Tim Burke | | 433 | 394 | 39 |
| 1991-08-02 | vs CHN | 101 | L 2-4 | 55-46 | 2 | 35,361 | Dwight Gooden | Mike Bielecki | Paul Assenmacher | Alejandro Pena | | 435 | 398 | 37 |
| 1991-08-03 | vs CHN | 102 | L 2-9 | 55-47 | 3 | 39,804 | Frank Viola | Danny Jackson | Bob Scanlan | Frank Viola | | 437 | 407 | 30 |
| 1991-08-04 | vs CHN | 103 | L 3-8 | 55-48 | 3 | 36,080 | David Cone | Greg Maddux | Greg Maddux | David Cone | | 440 | 415 | 25 |
| 1991-08-05 | vs CHN | 104 | L 2-7 | 55-49 | 3 | 27,508 | Pete Schourek | Frank Castillo | Frank Castillo | Pete Schourek | | 442 | 422 | 20 |
| 1991-08-06 | vs PIT | 105 | L 1-3 | 55-50 | 3 | 38,658 | Sid Fernandez | Randy Tomlin | Randy Tomlin | Sid Fernandez | | 443 | 425 | 18 |
| 1991-08-07 | vs PIT | 106 | W 7-1 | 56-50 | 3 | 41,542 | Dwight Gooden | Zane Smith | Dwight Gooden | Zane Smith | | 450 | 426 | 24 |
| 1991-08-08 | vs PIT | 107 | W 4-3 | 57-50 | 3 | 41,672 | Frank Viola | Doug Drabek | Frank Viola | Doug Drabek | John Franco | 454 | 429 | 25 |
| 1991-08-09 | @ CHN | 108 | L 4-5 | 57-51 | 3 | 36,110 | David Cone | Greg Maddux | Greg Maddux | David Cone | | 458 | 434 | 24 |
| 1991-08-10 | @ CHN | 109 | L 2-6 | 57-52 | 3 | 35,639 | Wally Whitehurst | Frank Castillo | Bob Scanlan | Tim Burke | Les Lancaster | 460 | 440 | 20 |
| 1991-08-11 | @ CHN | 110 | L 2-3 | 57-53 | 3 | 33,128 | Sid Fernandez | Rick Sutcliffe | Shawn Boskie | Pete Schourek | | 462 | 443 | 19 |
| 1991-08-12 | @ CHN | 111 | L 2-3 | 57-54 | 3 | 34,342 | Dwight Gooden | Mike Bielecki | Les Lancaster | Tim Burke | | 464 | 446 | 18 |
| 1991-08-13 | @ SLN | 112 | L 4-7 | 57-55 | 3 | 33,487 | Frank Viola | Omar Olivares | Omar Olivares | Frank Viola | Lee Smith | 468 | 453 | 15 |
| 1991-08-14 | @ SLN | 113 | L 4-5 | 57-56 | 3 | 31,399 | David Cone | Bryn Smith | Cris Carpenter | John Franco | Lee Smith | 472 | 458 | 14 |
| 1991-08-15 | @ SLN | 114 | L 1-4 | 57-57 | 4 | 32,096 | Wally Whitehurst | Rheal Cormier | Rheal Cormier | Wally Whitehurst | Lee Smith | 473 | 462 | 11 |
| 1991-08-16 | @ PIT | 115 | L 2-8 | 57-58 | 4 | 39,275 | Sid Fernandez | Randy Tomlin | Randy Tomlin | Sid Fernandez | | 475 | 470 | 5 |
| 1991-08-17 | @ PIT | 116 | L 1-4 | 57-59 | 4 | 44,707 | Dwight Gooden | Zane Smith | Zane Smith | Dwight Gooden | Stan Belinda | 476 | 474 | 2 |
| 1991-08-18 | @ PIT | 117 | L 2-9 | 57-60 | 4 | 36,014 | Frank Viola | Doug Drabek | Doug Drabek | Frank Viola | | 478 | 483 | -5 |
| 1991-08-21 | vs SLN | 118 | L 3-7 | 58-61 | 4 | 0 | David Cone | Bryn Smith | Bryn Smith | David Cone | | 481 | 490 | -9 |
| 1991-08-21 | vs SLN | 119 | W 8-0 | 58-61 | 4 | 26,169 | Sid Fernandez | Rheal Cormier | Sid Fernandez | Rheal Cormier | | 489 | 490 | -1 |
| 1991-08-22 | vs SLN | 120 | W 6-0 | 59-61 | 4 | 25,439 | Dwight Gooden | Bob Tewksbury | Dwight Gooden | Bob Tewksbury | Tim Burke | 495 | 490 | 5 |
| 1991-08-23 | vs CIN | 121 | L 1-6 | 59-62 | 4 | 28,967 | Frank Viola | Tom Browning | Tom Browning | Frank Viola | | 496 | 496 | 0 |
| 1991-08-24 | vs CIN | 122 | L 0-7 | 59-63 | 4 | 39,986 | Wally Whitehurst | Jose Rijo | Jose Rijo | Wally Whitehurst | | 496 | 503 | -7 |
| 1991-08-25 | vs CIN | 123 | W 2-1 | 60-63 | 4 | 26,399 | David Cone | Randy Myers | David Cone | Randy Myers | John Franco | 498 | 504 | -6 |
| 1991-08-26 | @ HOU | 124 | W 6-4 | 61-63 | 4 | 7,720 | Sid Fernandez | Pete Harnisch | John Franco | Dwayne Henry | | 504 | 508 | -4 |
| 1991-08-27 | @ HOU | 125 | L 3-8 | 61-64 | 4 | 9,175 | Wally Whitehurst | Darryl Kile | Darryl Kile | Wally Whitehurst | Curt Schilling | 507 | 516 | -9 |
| 1991-08-28 | @ ATL | 126 | L 1-3 | 61-65 | 4 | 25,060 | Frank Viola | Tom Glavine | Tom Glavine | Frank Viola | | 508 | 519 | -11 |
| 1991-08-29 | @ ATL | 127 | L 0-2 | 61-66 | 4 | 27,435 | Anthony Young | John Smoltz | John Smoltz | Anthony Young | Mike Stanton | 508 | 521 | -13 |
| 1991-08-30 | @ CIN | 128 | W 3-2 | 62-66 | 4 | 33,194 | David Cone | Randy Myers | David Cone | Randy Myers | John Franco | 511 | 523 | -12 |
| 1991-08-31 | @ CIN | 129 | W 8-7 | 63-66 | 4 | 39,006 | Pete Schourek | Mo Sanford | John Franco | Rob Dibble | | 519 | 530 | -11 |
| 1991-09-01 | @ CIN | 130 | W 9-4 | 64-66 | 4 | 30,641 | Wally Whitehurst | Scott Scudder | Wally Whitehurst | Scott Scudder | Doug Simons | 528 | 534 | -6 |
| 1991-09-02 | vs HOU | 131 | L 0-3 | 64-67 | 4 | 16,870 | Frank Viola | Ryan Bowen | Ryan Bowen | Frank Viola | Al Osuna | 528 | 537 | -9 |
| 1991-09-03 | vs HOU | 132 | W 6-1 | 65-67 | 4 | 12,974 | Anthony Young | Mark Portugal | Anthony Young | Mark Portugal | | 534 | 538 | -4 |
| 1991-09-04 | vs HOU | 133 | L 3-8 | 65-68 | 4 | 12,512 | David Cone | Jim Deshaies | Jim Deshaies | David Cone | | 537 | 546 | -9 |
| 1991-09-06 | vs ATL | 134 | L 2-4 | 65-69 | 4 | 21,960 | Wally Whitehurst | Kent Mercker | Alejandro Pena | Wally Whitehurst | Mike Stanton | 539 | 550 | -11 |
| 1991-09-07 | vs ATL | 135 | L 1-6 | 65-70 | 4 | 25,772 | Frank Viola | Charlie Leibrandt | Charlie Leibrandt | Frank Viola | | 540 | 556 | -16 |
| 1991-09-08 | vs ATL | 136 | L 5-7 | 65-71 | 4 | 22,449 | Anthony Young | Tom Glavine | Tom Glavine | John Franco | Alejandro Pena | 545 | 563 | -18 |
| 1991-09-09 | vs MON | 137 | L 3-4 | 65-72 | 4 | 12,950 | David Cone | Brian Barnes | Brian Barnes | David Cone | Jeff Fassero | 548 | 567 | -19 |
| 1991-09-10 | vs MON | 138 | W 9-0 | 66-72 | 4 | 9,882 | Pete Schourek | Mark Gardner | Pete Schourek | Mark Gardner | | 557 | 567 | -10 |
| 1991-09-11 | @ CHN | 139 | W 4-1 | 67-72 | 4 | 15,795 | Tony Castillo | Frank Castillo | Tony Castillo | Frank Castillo | John Franco | 561 | 568 | -7 |
| 1991-09-12 | @ CHN | 140 | W 6-3 | 68-72 | 4 | 14,324 | Anthony Young | Mike Bielecki | Anthony Young | Mike Bielecki | Wally Whitehurst | 567 | 571 | -4 |
| 1991-09-13 | @ SLN | 141 | W 4-2 | 69-72 | 4 | 26,680 | Frank Viola | Mark Clark | Tim Burke | Willie Fraser | | 571 | 573 | -2 |
| 1991-09-14 | @ SLN | 142 | L 1-2 | 69-73 | 4 | 31,583 | David Cone | Omar Olivares | Omar Olivares | David Cone | Lee Smith | 572 | 575 | -3 |
| 1991-09-15 | @ SLN | 143 | L 2-7 | 69-74 | 4 | 26,379 | Pete Schourek | Rheal Cormier | Rheal Cormier | Pete Schourek | | 574 | 582 | -8 |
| 1991-09-17 | vs MON | 144 | L 4-5 | 70-75 | 4 | 0 | Anthony Young | Chris Nabholz | Chris Nabholz | Anthony Young | Mel Rojas | 578 | 587 | -9 |
| 1991-09-17 | vs MON | 145 | W 3-2 | 70-75 | 4 | 4,355 | Tony Castillo | Chris Haney | Wally Whitehurst | Chris Haney | John Franco | 581 | 589 | -8 |
| 1991-09-18 | vs CHN | 146 | L 1-4 | 70-76 | 4 | 11,980 | Frank Viola | Greg Maddux | Greg Maddux | Frank Viola | | 582 | 593 | -11 |
| 1991-09-20 | vs SLN | 147 | W 1-0 | 71-76 | 4 | 15,683 | David Cone | Rheal Cormier | David Cone | Rheal Cormier | | 583 | 593 | -10 |
| 1991-09-21 | vs SLN | 148 | W 5-3 | 72-76 | 3 | 20,887 | Pete Schourek | Bob Tewksbury | Pete Schourek | Bob Tewksbury | John Franco | 588 | 596 | -8 |
| 1991-09-22 | vs SLN | 149 | L 1-2 | 72-77 | 3 | 21,113 | Anthony Young | Ken Hill | Ken Hill | Anthony Young | Lee Smith | 589 | 598 | -9 |
| 1991-09-24 | vs PIT | 150 | L 8-10 | 72-78 | 4 | 12,336 | Frank Viola | Bob Walk | Bob Patterson | Jeff Innis | Rosario Rodriguez | 597 | 608 | -11 |
| 1991-09-26 | vs PIT | 151 | L 3-4 | 73-79 | 3 | 0 | David Cone | Randy Tomlin | Bill Landrum | Wally Whitehurst | | 600 | 612 | -12 |
| 1991-09-26 | vs PIT | 152 | W 2-1 | 73-79 | 3 | 14,451 | Tony Castillo | John Smiley | Tim Burke | Roger Mason | John Franco | 602 | 613 | -11 |
| 1991-09-27 | vs PHI | 153 | W 6-4 | 74-79 | 3 | 13,680 | Pete Schourek | Jose De Jesus | Pete Schourek | Jose De Jesus | John Franco | 608 | 617 | -9 |
| 1991-09-28 | vs PHI | 154 | L 2-6 | 74-80 | 3 | 16,967 | Anthony Young | Cliff Brantley | Cliff Brantley | Anthony Young | | 610 | 623 | -13 |
| 1991-09-29 | vs PHI | 155 | W 4-3 | 75-80 | 3 | 16,573 | Frank Viola | Terry Mulholland | Frank Viola | Terry Mulholland | John Franco | 614 | 626 | -12 |
| 1991-09-30 | @ PIT | 156 | L 5-6 | 75-81 | 3 | 16,170 | Doug Simons | Vicente Palacios | Bill Landrum | Doug Simons | Rosario Rodriguez | 619 | 632 | -13 |
| 1991-10-01 | @ PIT | 157 | L 1-2 | 75-82 | 4 | 14,697 | David Cone | Zane Smith | John Smiley | David Cone | Stan Belinda | 620 | 634 | -14 |
| 1991-10-02 | @ PIT | 158 | W 9-6 | 76-82 | 3 | 13,328 | Pete Schourek | Randy Tomlin | John Franco | Bob Patterson | | 629 | 640 | -11 |
| 1991-10-04 | @ PHI | 159 | L 4-5 | 76-83 | 4 | 20,720 | Frank Viola | Cliff Brantley | Mitch Williams | John Franco | | 633 | 645 | -12 |
| 1991-10-05 | @ PHI | 160 | L 0-1 | 76-84 | 5 | 22,281 | Anthony Young | Terry Mulholland | Terry Mulholland | Anthony Young | | 633 | 646 | -13 |
| 1991-10-06 | @ PHI | 161 | W 7-0 | 77-84 | 5 | 29,676 | David Cone | Andy Ashby | David Cone | Andy Ashby | | 640 | 646 | -6 |