| 1991-04-08 | @ TEX | 1 | W 5-4 | - | | 40,560 | Mark Knudson | Nolan Ryan | Mark Knudson | Nolan Ryan | Ed Nunez | 5 | 4 | 1 |
| 1991-04-10 | @ TEX | 2 | W 6-0 | - | | 15,293 | Chris Bosio | Kevin Brown | Chris Bosio | Kevin Brown | | 11 | 4 | 7 |
| 1991-04-11 | @ TOR | 3 | L 3-7 | - | | 38,286 | Ron Robinson | David Wells | David Wells | Ron Robinson | | 14 | 11 | 3 |
| 1991-04-12 | @ TOR | 4 | L 4-5 | - | | 43,150 | Jaime Navarro | Denis Boucher | Mike Timlin | Dan Plesac | | 18 | 16 | 2 |
| 1991-04-13 | @ TOR | 5 | W 7-3 | - | | 49,872 | Kevin Brown | Dave Stieb | Kevin Brown | Dave Stieb | Chuck Crim | 25 | 19 | 6 |
| 1991-04-14 | @ TOR | 6 | L 0-9 | - | | 47,136 | Don August | Jimmy Key | Jimmy Key | Don August | | 25 | 28 | -3 |
| 1991-04-15 | vs BAL | 7 | L 2-7 | - | | 50,058 | Chris Bosio | Jose Mesa | Jose Mesa | Chris Bosio | Mark Williamson | 27 | 35 | -8 |
| 1991-04-17 | vs BAL | 8 | W 7-3 | - | | 8,053 | Jaime Navarro | Dave Johnson | Jaime Navarro | Dave Johnson | Mark Lee | 34 | 38 | -4 |
| 1991-04-18 | vs BAL | 9 | W 4-3 | - | | 7,693 | Mark Knudson | Jeff Ballard | Ed Nunez | Jose Bautista | | 38 | 41 | -3 |
| 1991-04-19 | vs TOR | 10 | L 2-5 | - | | 9,604 | Don August | Dave Stieb | Dave Stieb | Don August | | 40 | 46 | -6 |
| 1991-04-20 | vs TOR | 11 | L 2-4 | - | | 13,545 | Chris Bosio | Jimmy Key | Jimmy Key | Chris Bosio | Duane Ward | 42 | 50 | -8 |
| 1991-04-21 | vs TOR | 12 | W 11-8 | - | | 14,920 | Kevin Brown | Todd Stottlemyre | Chuck Crim | Frank Wills | | 53 | 58 | -5 |
| 1991-04-23 | vs TEX | 13 | L 5-6 | - | | 6,896 | Jaime Navarro | Bobby Witt | Rich Gossage | Chuck Crim | Jeff Russell | 58 | 64 | -6 |
| 1991-04-24 | vs TEX | 14 | L 2-8 | - | | 9,822 | Mark Knudson | Kevin Brown | Kevin Brown | Mark Knudson | | 60 | 72 | -12 |
| 1991-04-25 | vs TEX | 15 | W 9-1 | - | | 10,034 | Chris Bosio | Kenny Rogers | Chris Bosio | Kenny Rogers | | 69 | 73 | -4 |
| 1991-04-26 | @ BAL | 16 | W 5-4 | - | | 28,657 | Kevin Brown | Jose Mesa | Darren Holmes | Jose Mesa | Ed Nunez | 74 | 77 | -3 |
| 1991-04-27 | @ BAL | 17 | W 5-2 | - | | 31,488 | Don August | Jeff Robinson | Don August | Jeff Robinson | | 79 | 79 | 0 |
| 1991-04-28 | @ BAL | 18 | L 4-5 | - | | 32,989 | Jaime Navarro | Ben McDonald | Bob Milacki | Darren Holmes | Gregg Olson | 83 | 84 | -1 |
| 1991-04-30 | vs CHA | 19 | W 8-2 | - | | 9,136 | Chris Bosio | Alex Fernandez | Chris Bosio | Alex Fernandez | Chuck Crim | 91 | 86 | 5 |
| 1991-05-01 | vs CHA | 20 | W 10-9 | - | | 13,973 | Mark Knudson | Greg Hibbard | Don August | Wayne Edwards | | 101 | 95 | 6 |
| 1991-05-02 | vs MIN | 21 | W 5-1 | - | | 8,902 | Kevin Brown | Kevin Tapani | Kevin Brown | Kevin Tapani | Chuck Crim | 106 | 96 | 10 |
| 1991-05-03 | vs MIN | 22 | W 6-5 | - | | 13,033 | Jaime Navarro | Jack Morris | Jaime Navarro | Rick Aguilera | Ed Nunez | 112 | 101 | 11 |
| 1991-05-04 | vs MIN | 23 | L 4-7 | - | | 26,503 | Chris Bosio | Mark Guthrie | Mark Guthrie | Chris Bosio | Steve Bedrosian | 116 | 108 | 8 |
| 1991-05-05 | vs MIN | 24 | L 2-5 | - | | 11,183 | Bill Wegman | Allan Anderson | Rick Aguilera | Ed Nunez | | 118 | 113 | 5 |
| 1991-05-07 | @ CHA | 25 | L 1-2 | - | | 35,451 | Kevin Brown | Greg Hibbard | Bobby Thigpen | Mark Lee | | 119 | 115 | 4 |
| 1991-05-08 | @ CHA | 26 | L 1-2 | - | | 36,026 | Jaime Navarro | Jack McDowell | Jack McDowell | Jaime Navarro | | 120 | 117 | 3 |
| 1991-05-10 | vs KCA | 27 | L 1-2 | - | | 18,915 | Chris Bosio | Bret Saberhagen | Bret Saberhagen | Chris Bosio | | 121 | 119 | 2 |
| 1991-05-11 | vs KCA | 28 | L 2-4 | - | | 27,372 | Bill Wegman | Tom Gordon | Tom Gordon | Bill Wegman | Jeff Montgomery | 123 | 123 | 0 |
| 1991-05-12 | vs KCA | 29 | L 4-6 | - | | 15,119 | Kevin Brown | Mike Boddicker | Mike Boddicker | Kevin Brown | Jeff Montgomery | 127 | 129 | -2 |
| 1991-05-14 | @ MIN | 30 | L 1-5 | - | | 13,395 | Jaime Navarro | Jack Morris | Jack Morris | Jaime Navarro | | 128 | 134 | -6 |
| 1991-05-15 | @ MIN | 31 | W 4-2 | - | | 15,992 | Chris Bosio | Kevin Tapani | Chris Bosio | Kevin Tapani | Dan Plesac | 132 | 136 | -4 |
| 1991-05-16 | @ MIN | 32 | W 6-3 | - | | 15,182 | Bill Wegman | Allan Anderson | Bill Wegman | Allan Anderson | Darren Holmes | 138 | 139 | -1 |
| 1991-05-17 | @ KCA | 33 | W 7-5 | - | | 26,644 | Kevin Brown | Tom Gordon | Chuck Crim | Mark Davis | Julio Machado | 145 | 144 | 1 |
| 1991-05-18 | @ KCA | 34 | L 4-7 | - | | 34,727 | Don August | Storm Davis | Mark Davis | Mark Lee | Jeff Montgomery | 149 | 151 | -2 |
| 1991-05-19 | @ KCA | 35 | W 4-2 | - | | 26,483 | Jaime Navarro | Mark Gubicza | Jaime Navarro | Mark Gubicza | Julio Machado | 153 | 153 | 0 |
| 1991-05-20 | @ BOS | 36 | L 0-3 | - | | 28,983 | Chris Bosio | Matt Young | Matt Young | Chris Bosio | Jeff Reardon | 153 | 156 | -3 |
| 1991-05-21 | @ BOS | 37 | L 6-10 | - | | 28,646 | Bill Wegman | Dana Kiecker | Joe Hesketh | Jim Hunter | | 159 | 166 | -7 |
| 1991-05-22 | @ BOS | 38 | L 0-4 | - | | 33,182 | Kevin Brown | Danny Darwin | Danny Darwin | Kevin Brown | Greg Harris | 159 | 170 | -11 |
| 1991-05-23 | vs CLE | 39 | W 7-3 | - | | 12,623 | Don August | Charles Nagy | Don August | Charles Nagy | Darren Holmes | 166 | 173 | -7 |
| 1991-05-24 | vs CLE | 40 | W 1-0 | - | | 16,598 | Jaime Navarro | Rod Nichols | Jaime Navarro | Rod Nichols | | 167 | 173 | -6 |
| 1991-05-25 | vs CLE | 41 | L 4-5 | - | | 17,664 | Chris Bosio | Eric King | Doug Jones | Julio Machado | | 171 | 178 | -7 |
| 1991-05-26 | vs CLE | 42 | W 7-6 | - | | 23,214 | Bill Wegman | Greg Swindell | Chuck Crim | Doug Jones | | 178 | 184 | -6 |
| 1991-05-27 | vs DET | 43 | L 9-15 | - | | 27,667 | Kevin Brown | Bill Gullickson | Mike Henneman | Chuck Crim | | 187 | 199 | -12 |
| 1991-05-28 | vs DET | 44 | W 15-2 | - | | 12,981 | Don August | Frank Tanana | Don August | Frank Tanana | | 202 | 201 | 1 |
| 1991-05-29 | vs DET | 45 | W 6-2 | - | | 21,673 | Jaime Navarro | Walt Terrell | Jaime Navarro | Walt Terrell | | 208 | 203 | 5 |
| 1991-05-31 | @ NYA | 46 | L 2-3 | - | | 19,084 | Chris Bosio | Pascual Perez | Steve Howe | Chuck Crim | | 210 | 206 | 4 |
| 1991-06-01 | @ NYA | 47 | W 6-3 | - | | 23,599 | Bill Wegman | Chuck Cary | Bill Wegman | Chuck Cary | | 216 | 209 | 7 |
| 1991-06-02 | @ NYA | 48 | L 4-7 | - | | 30,507 | Teddy Higuera | Wade Taylor | Wade Taylor | Teddy Higuera | Steve Farr | 220 | 216 | 4 |
| 1991-06-04 | @ OAK | 49 | L 3-4 | - | | 22,214 | Jaime Navarro | Bob Welch | Bob Welch | Jaime Navarro | Dennis Eckersley | 223 | 220 | 3 |
| 1991-06-05 | @ OAK | 50 | L 4-6 | - | | 21,271 | Chris Bosio | Dave Stewart | Dave Stewart | Chris Bosio | Steve Chitren | 227 | 226 | 1 |
| 1991-06-06 | @ OAK | 51 | L 8-9 | - | | 26,365 | Don August | Andy Hawkins | Bruce Walton | Chuck Crim | Dennis Eckersley | 235 | 235 | 0 |
| 1991-06-07 | @ SEA | 52 | L 1-2 | - | | 16,968 | Teddy Higuera | Bill Krueger | Bill Krueger | Teddy Higuera | Michael Jackson | 236 | 237 | -1 |
| 1991-06-08 | @ SEA | 53 | L 2-6 | - | | 25,835 | Bill Wegman | Rich DeLucia | Rich DeLucia | Bill Wegman | Dave Burba | 238 | 243 | -5 |
| 1991-06-09 | @ SEA | 54 | L 1-6 | - | | 41,397 | Jaime Navarro | Brian Holman | Brian Holman | Jaime Navarro | | 239 | 249 | -10 |
| 1991-06-10 | @ CAL | 55 | W 7-2 | - | | 21,147 | Chris Bosio | Kirk McCaskill | Chris Bosio | Kirk McCaskill | | 246 | 251 | -5 |
| 1991-06-11 | @ CAL | 56 | L 3-4 | - | | 23,044 | Don August | Mark Langston | Mark Langston | Kevin Brown | Bryan Harvey | 249 | 255 | -6 |
| 1991-06-12 | @ CAL | 57 | W 8-0 | - | | 32,515 | Teddy Higuera | Fernando Valenzuela | Teddy Higuera | Fernando Valenzuela | | 257 | 255 | 2 |
| 1991-06-15 | vs OAK | 58 | W 6-4 | - | | 0 | Jaime Navarro | Dave Stewart | Jaime Navarro | Dave Stewart | Dan Plesac | 263 | 259 | 4 |
| 1991-06-15 | vs OAK | 59 | L 3-7 | - | | 33,797 | Kevin Brown | Andy Hawkins | Andy Hawkins | Kevin Brown | Steve Chitren | 266 | 266 | 0 |
| 1991-06-16 | vs OAK | 60 | W 11-7 | - | | 28,774 | Chris Bosio | Joe Slusarski | Chuck Crim | Gene Nelson | | 277 | 273 | 4 |
| 1991-06-17 | vs OAK | 61 | W 5-0 | - | | 20,431 | Don August | Mike Moore | Don August | Mike Moore | | 282 | 273 | 9 |
| 1991-06-18 | vs CAL | 62 | W 10-6 | - | | 17,915 | Teddy Higuera | Joe Grahe | Teddy Higuera | Joe Grahe | Dan Plesac | 292 | 279 | 13 |
| 1991-06-19 | vs CAL | 63 | L 1-4 | - | | 26,512 | Bill Wegman | Jim Abbott | Jim Abbott | Bill Wegman | Bryan Harvey | 293 | 283 | 10 |
| 1991-06-20 | vs SEA | 64 | W 4-0 | - | | 19,174 | Jaime Navarro | Brian Holman | Jaime Navarro | Brian Holman | | 297 | 283 | 14 |
| 1991-06-21 | vs SEA | 65 | L 1-5 | - | | 18,409 | Chris Bosio | Randy Johnson | Randy Johnson | Chris Bosio | | 298 | 288 | 10 |
| 1991-06-22 | vs SEA | 66 | L 0-5 | - | | 25,260 | Don August | Erik Hanson | Erik Hanson | Don August | | 298 | 293 | 5 |
| 1991-06-23 | vs SEA | 67 | W 5-2 | - | | 25,159 | Teddy Higuera | Bill Krueger | Teddy Higuera | Bill Krueger | Dan Plesac | 303 | 295 | 8 |
| 1991-06-25 | @ DET | 68 | W 11-3 | - | | 13,765 | Bill Wegman | Walt Terrell | Bill Wegman | Walt Terrell | | 314 | 298 | 16 |
| 1991-06-26 | @ DET | 69 | L 7-8 | - | | 13,355 | Jaime Navarro | Dan Gakeler | John Cerutti | Julio Machado | | 321 | 306 | 15 |
| 1991-06-27 | @ DET | 70 | W 9-3 | - | | 13,606 | Chris Bosio | Bill Gullickson | Chris Bosio | Bill Gullickson | | 330 | 309 | 21 |
| 1991-06-28 | vs NYA | 71 | W 5-2 | - | | 19,442 | Don August | Scott Kamieniecki | Don August | Scott Kamieniecki | Dan Plesac | 335 | 311 | 24 |
| 1991-06-29 | vs NYA | 72 | L 8-9 | - | | 31,992 | Teddy Higuera | Jeff Johnson | Lee Guetterman | Dan Plesac | Steve Farr | 343 | 320 | 23 |
| 1991-06-30 | vs NYA | 73 | L 6-8 | - | | 27,400 | Bill Wegman | Tim Leary | Greg Cadaret | Mark Lee | Steve Farr | 349 | 328 | 21 |
| 1991-07-01 | vs BOS | 74 | L 0-6 | - | | 14,955 | Jaime Navarro | Roger Clemens | Roger Clemens | Jaime Navarro | | 349 | 334 | 15 |
| 1991-07-02 | vs BOS | 75 | L 4-14 | - | | 16,019 | Mark Knudson | Tom Bolton | Dennis Lamp | Mark Knudson | | 353 | 348 | 5 |
| 1991-07-03 | vs BOS | 76 | L 3-5 | - | | 23,935 | Don August | Greg Harris | Greg Harris | Don August | Jeff Reardon | 356 | 353 | 3 |
| 1991-07-04 | @ CLE | 77 | L 0-3 | - | | 25,699 | Jim Hunter | Charles Nagy | Charles Nagy | Jim Hunter | | 356 | 356 | 0 |
| 1991-07-05 | @ CLE | 78 | W 4-2 | - | | 13,221 | Bill Wegman | Rod Nichols | Bill Wegman | Rod Nichols | Dan Plesac | 360 | 358 | 2 |
| 1991-07-06 | @ CLE | 79 | L 0-2 | - | | 15,461 | Jaime Navarro | Greg Swindell | Greg Swindell | Jaime Navarro | Shawn Hillegas | 360 | 360 | 0 |
| 1991-07-07 | @ CLE | 80 | W 10-6 | - | | 14,989 | Mark Knudson | Mike York | Chuck Crim | Jeff Shaw | Dan Plesac | 370 | 366 | 4 |
| 1991-07-11 | vs CHA | 81 | W 5-1 | - | | 23,875 | Bill Wegman | Charlie Hough | Bill Wegman | Charlie Hough | | 375 | 367 | 8 |
| 1991-07-12 | vs CHA | 82 | L 6-8 | - | | 24,102 | Jaime Navarro | Alex Fernandez | Melido Perez | Dan Plesac | Bobby Thigpen | 381 | 375 | 6 |
| 1991-07-13 | vs CHA | 83 | W 8-2 | - | | 44,850 | Don August | Greg Hibbard | Don August | Greg Hibbard | | 389 | 377 | 12 |
| 1991-07-14 | vs CHA | 84 | L 1-15 | - | | 31,345 | Mark Knudson | Jack McDowell | Jack McDowell | Mark Knudson | | 390 | 392 | -2 |
| 1991-07-15 | vs MIN | 85 | L 7-11 | - | | 16,201 | Jim Hunter | Scott Erickson | Mark Guthrie | Jim Hunter | Steve Bedrosian | 397 | 403 | -6 |
| 1991-07-16 | vs MIN | 86 | W 4-3 | - | | 15,954 | Chris Bosio | Kevin Tapani | Doug Henry | Rick Aguilera | | 401 | 406 | -5 |
| 1991-07-17 | vs SEA | 87 | W 6-1 | - | | 16,059 | Bill Wegman | Randy Johnson | Bill Wegman | Randy Johnson | | 407 | 407 | 0 |
| 1991-07-18 | vs SEA | 88 | L 0-12 | - | | 26,621 | Jaime Navarro | Erik Hanson | Erik Hanson | Jaime Navarro | | 407 | 419 | -12 |
| 1991-07-19 | @ CHA | 89 | L 3-14 | - | | 42,055 | Don August | Jack McDowell | Jack McDowell | Don August | | 410 | 433 | -23 |
| 1991-07-20 | @ CHA | 90 | L 6-7 | - | | 40,583 | Jim Hunter | Ramon Garcia | Bobby Thigpen | Dan Plesac | | 416 | 440 | -24 |
| 1991-07-21 | @ CHA | 91 | W 2-1 | - | | 41,207 | Chris Bosio | Charlie Hough | Chris Bosio | Charlie Hough | | 418 | 441 | -23 |
| 1991-07-22 | @ CHA | 92 | L 4-5 | - | | 42,295 | Bill Wegman | Greg Hibbard | Greg Hibbard | Bill Wegman | Bobby Thigpen | 422 | 446 | -24 |
| 1991-07-23 | @ KCA | 93 | L 7-8 | - | | 23,169 | Jaime Navarro | Mark Gubicza | Mark Gubicza | Jaime Navarro | Jeff Montgomery | 429 | 454 | -25 |
| 1991-07-24 | @ KCA | 94 | L 4-7 | - | | 26,620 | Don August | Bret Saberhagen | Storm Davis | Chuck Crim | Jeff Montgomery | 433 | 461 | -28 |
| 1991-07-25 | @ KCA | 95 | L 0-2 | - | | 30,309 | Jim Hunter | Luis Aquino | Luis Aquino | Jim Hunter | Jeff Montgomery | 433 | 463 | -30 |
| 1991-07-26 | @ MIN | 96 | L 3-6 | - | | 39,211 | Chris Bosio | Kevin Tapani | Kevin Tapani | Darren Holmes | Rick Aguilera | 436 | 469 | -33 |
| 1991-07-27 | @ MIN | 97 | L 4-7 | - | | 47,632 | Bill Wegman | Denny Neagle | Carl Willis | Bill Wegman | | 440 | 476 | -36 |
| 1991-07-28 | @ MIN | 98 | W 11-2 | - | | 47,524 | Jaime Navarro | Jack Morris | Jaime Navarro | Jack Morris | | 451 | 478 | -27 |
| 1991-07-30 | vs KCA | 99 | W 9-3 | - | | 18,952 | Don August | Bret Saberhagen | Don August | Bret Saberhagen | Dan Plesac | 460 | 481 | -21 |
| 1991-07-31 | vs KCA | 100 | L 4-5 | - | | 15,941 | Chris Bosio | Luis Aquino | Luis Aquino | Chris Bosio | Jeff Montgomery | 464 | 486 | -22 |
| 1991-08-01 | vs KCA | 101 | L 5-6 | - | | 20,631 | Jim Hunter | Mike Boddicker | Tom Gordon | Darren Holmes | Jeff Montgomery | 469 | 492 | -23 |
| 1991-08-02 | vs TEX | 102 | L 1-15 | - | | 22,323 | Jaime Navarro | Brian Bohanon | Brian Bohanon | Jaime Navarro | | 470 | 507 | -37 |
| 1991-08-03 | vs TEX | 103 | L 5-14 | - | | 31,312 | Bill Wegman | Jose Guzman | Jose Guzman | Bill Wegman | | 475 | 521 | -46 |
| 1991-08-04 | vs TEX | 104 | W 3-2 | - | | 28,464 | Chris Bosio | Oil Can Boyd | Chuck Crim | Jeff Russell | | 478 | 523 | -45 |
| 1991-08-05 | @ BAL | 105 | W 6-5 | - | | 25,824 | Don August | Roy Smith | Doug Henry | Mark Williamson | Ed Nunez | 484 | 528 | -44 |
| 1991-08-06 | @ BAL | 106 | L 5-13 | - | | 25,883 | Jim Hunter | Dave Johnson | Dave Johnson | Jim Hunter | | 489 | 541 | -52 |
| 1991-08-07 | @ BAL | 107 | W 4-2 | - | | 24,239 | Jaime Navarro | Ben McDonald | Jaime Navarro | Ben McDonald | | 493 | 543 | -50 |
| 1991-08-08 | @ BAL | 108 | W 6-4 | - | | 27,079 | Bill Wegman | Bob Milacki | Bill Wegman | Bob Milacki | Ed Nunez | 499 | 547 | -48 |
| 1991-08-09 | @ TEX | 109 | W 10-8 | - | | 35,009 | Chris Bosio | Jose Guzman | Chris Bosio | Gerald Alexander | Ed Nunez | 509 | 555 | -46 |
| 1991-08-10 | @ TEX | 110 | W 5-2 | - | | 41,286 | Dan Plesac | Oil Can Boyd | Dan Plesac | Oil Can Boyd | Doug Henry | 514 | 557 | -43 |
| 1991-08-11 | @ TEX | 111 | L 4-5 | - | | 31,169 | Don August | Kevin Brown | Kenny Rogers | Julio Machado | | 518 | 562 | -44 |
| 1991-08-12 | @ TEX | 112 | W 14-7 | - | | 21,590 | Jaime Navarro | Bobby Witt | Jaime Navarro | Bobby Witt | Doug Henry | 532 | 569 | -37 |
| 1991-08-13 | vs TOR | 113 | W 5-4 | - | | 22,996 | Bill Wegman | Tom Candiotti | Chuck Crim | Tom Henke | | 537 | 573 | -36 |
| 1991-08-14 | vs TOR | 114 | W 5-3 | - | | 19,193 | Chris Bosio | David Wells | Chris Bosio | David Wells | Doug Henry | 542 | 576 | -34 |
| 1991-08-15 | vs TOR | 115 | L 1-4 | - | | 24,519 | Dan Plesac | Todd Stottlemyre | Todd Stottlemyre | Dan Plesac | Tom Henke | 543 | 580 | -37 |
| 1991-08-16 | vs BAL | 116 | W 8-5 | - | | 18,050 | Don August | Dave Johnson | Don August | Roy Smith | | 551 | 585 | -34 |
| 1991-08-17 | vs BAL | 117 | W 7-6 | - | | 31,063 | Jaime Navarro | Ben McDonald | Jaime Navarro | Ben McDonald | Ed Nunez | 558 | 591 | -33 |
| 1991-08-18 | vs BAL | 118 | W 2-1 | - | | 22,638 | Bill Wegman | Bob Milacki | Bill Wegman | Bob Milacki | Doug Henry | 560 | 592 | -32 |
| 1991-08-20 | @ TOR | 119 | L 1-3 | - | | 50,311 | Chris Bosio | Todd Stottlemyre | Todd Stottlemyre | Chris Bosio | Tom Henke | 561 | 595 | -34 |
| 1991-08-21 | @ TOR | 120 | W 3-0 | - | | 50,306 | Dan Plesac | Jimmy Key | Julio Machado | Jimmy Key | Ed Nunez | 564 | 595 | -31 |
| 1991-08-22 | @ TOR | 121 | W 8-7 | - | | 50,309 | Don August | Juan Guzman | Mike Ignasiak | Duane Ward | Doug Henry | 572 | 602 | -30 |
| 1991-08-23 | @ OAK | 122 | W 13-4 | - | | 30,115 | Jaime Navarro | Dave Stewart | Jaime Navarro | Dave Stewart | | 585 | 606 | -21 |
| 1991-08-24 | @ OAK | 123 | W 7-0 | - | | 41,317 | Bill Wegman | Joe Slusarski | Bill Wegman | Joe Slusarski | | 592 | 606 | -14 |
| 1991-08-25 | @ OAK | 124 | W 8-2 | - | | 37,624 | Chris Bosio | Ron Darling | Chris Bosio | Ron Darling | | 600 | 608 | -8 |
| 1991-08-26 | @ SEA | 125 | L 4-5 | - | | 22,079 | Mike Ignasiak | Bill Krueger | Mike Schooler | Doug Henry | | 604 | 613 | -9 |
| 1991-08-27 | @ SEA | 126 | L 4-6 | - | | 12,067 | Don August | Rich DeLucia | Rich DeLucia | Don August | Michael Jackson | 608 | 619 | -11 |
| 1991-08-28 | @ SEA | 127 | L 6-7 | - | | 11,470 | Jaime Navarro | Brian Holman | Brian Holman | Jaime Navarro | Bill Swift | 614 | 626 | -12 |
| 1991-08-30 | vs CAL | 128 | W 6-2 | - | | 16,606 | Bill Wegman | Kirk McCaskill | Bill Wegman | Kirk McCaskill | | 620 | 628 | -8 |
| 1991-08-31 | vs CAL | 129 | W 8-2 | - | | 18,313 | Chris Bosio | Joe Grahe | Mark Lee | Joe Grahe | | 628 | 630 | -2 |
| 1991-09-01 | vs CAL | 130 | W 3-1 | - | | 12,710 | Jaime Navarro | Chuck Finley | Jaime Navarro | Chuck Finley | | 631 | 631 | 0 |
| 1991-09-02 | vs CAL | 131 | L 6-7 | - | | 22,517 | Don August | Jim Abbott | Jim Abbott | Don August | Bryan Harvey | 637 | 638 | -1 |
| 1991-09-03 | vs OAK | 132 | W 5-3 | - | | 9,047 | Dan Plesac | Dave Stewart | Ed Nunez | Dennis Eckersley | | 642 | 641 | 1 |
| 1991-09-04 | vs OAK | 133 | W 2-0 | - | | 12,599 | Bill Wegman | Ron Darling | Bill Wegman | Ron Darling | Doug Henry | 644 | 641 | 3 |
| 1991-09-06 | @ CAL | 134 | L 1-2 | - | | 21,417 | Chris Bosio | Joe Grahe | Joe Grahe | Chris Bosio | | 645 | 643 | 2 |
| 1991-09-07 | @ CAL | 135 | L 0-1 | - | | 26,366 | Jaime Navarro | Chuck Finley | Chuck Finley | Jaime Navarro | Bryan Harvey | 645 | 644 | 1 |
| 1991-09-08 | @ CAL | 136 | L 0-1 | - | | 21,390 | Dan Plesac | Jim Abbott | Jim Abbott | Dan Plesac | Bryan Harvey | 645 | 645 | 0 |
| 1991-09-10 | vs CLE | 137 | L 2-5 | - | | 7,950 | Bill Wegman | Doug Jones | Doug Jones | Bill Wegman | Steve Olin | 647 | 650 | -3 |
| 1991-09-12 | vs DET | 138 | W 7-0 | - | | 9,835 | Chris Bosio | Mark Leiter | Chris Bosio | Mark Leiter | | 654 | 650 | 4 |
| 1991-09-13 | vs DET | 139 | L 2-3 | - | | 14,554 | Jaime Navarro | Bill Gullickson | Bill Gullickson | Mark Lee | Jeff Kaiser | 656 | 653 | 3 |
| 1991-09-14 | vs DET | 140 | L 4-6 | - | | 26,644 | Dan Plesac | Scott Aldred | Scott Aldred | Dan Plesac | | 660 | 659 | 1 |
| 1991-09-15 | vs DET | 141 | W 5-3 | - | | 13,296 | Bill Wegman | Frank Tanana | Bill Wegman | Frank Tanana | Doug Henry | 665 | 662 | 3 |
| 1991-09-16 | @ NYA | 142 | W 5-4 | - | | 17,751 | Don August | Wade Taylor | Mark Lee | Wade Taylor | Doug Henry | 670 | 666 | 4 |
| 1991-09-17 | @ NYA | 143 | W 2-0 | - | | 12,575 | Chris Bosio | Pascual Perez | Chris Bosio | Pascual Perez | | 672 | 666 | 6 |
| 1991-09-18 | @ NYA | 144 | L 1-2 | - | | 13,160 | Jaime Navarro | Jeff Johnson | Steve Farr | Jaime Navarro | | 673 | 668 | 5 |
| 1991-09-20 | @ DET | 145 | W 8-5 | - | | 13,966 | Dan Plesac | Mark Leiter | Dan Plesac | Mark Leiter | Doug Henry | 681 | 673 | 8 |
| 1991-09-21 | @ DET | 146 | W 5-2 | - | | 18,317 | Bill Wegman | Frank Tanana | Bill Wegman | Frank Tanana | Doug Henry | 686 | 675 | 11 |
| 1991-09-22 | @ DET | 147 | W 9-5 | - | | 15,752 | Chris Bosio | Walt Terrell | Chris Bosio | Walt Terrell | | 695 | 680 | 15 |
| 1991-09-23 | vs NYA | 148 | L 8-9 | - | | 8,193 | Jaime Navarro | Jeff Johnson | Rich Monteleone | Mark Lee | Steve Farr | 703 | 689 | 14 |
| 1991-09-24 | vs NYA | 149 | W 5-4 | - | | 9,378 | Cal Eldred | Eric Plunk | Cal Eldred | Eric Plunk | Doug Henry | 708 | 693 | 15 |
| 1991-09-25 | vs NYA | 150 | L 6-8 | - | | 7,691 | Dan Plesac | Scott Sanderson | Alan Mills | Don August | | 714 | 701 | 13 |
| 1991-09-26 | vs NYA | 151 | W 6-2 | - | | 9,841 | Bill Wegman | Wade Taylor | Bill Wegman | Wade Taylor | | 720 | 703 | 17 |
| 1991-09-27 | vs BOS | 152 | W 7-5 | - | | 11,944 | Chris Bosio | Kevin Morton | Chris Bosio | Kevin Morton | Julio Machado | 727 | 708 | 19 |
| 1991-09-28 | vs BOS | 153 | W 4-1 | - | | 14,856 | Jaime Navarro | Mike Gardiner | Jaime Navarro | Mike Gardiner | Doug Henry | 731 | 709 | 22 |
| 1991-09-29 | vs BOS | 154 | W 5-4 | - | | 12,063 | Cal Eldred | Tom Bolton | Julio Machado | Jeff Reardon | Doug Henry | 736 | 713 | 23 |
| 1991-09-30 | vs BOS | 155 | L 8-9 | - | | 9,333 | Dan Plesac | Greg Harris | Dennis Lamp | Mike Ignasiak | Dan Petry | 744 | 722 | 22 |
| 1991-10-01 | @ CLE | 156 | W 11-0 | - | | 0 | Bill Wegman | Rod Nichols | Bill Wegman | Rod Nichols | | 755 | 722 | 33 |
| 1991-10-01 | @ CLE | 157 | L 2-6 | - | | 4,346 | Chris George | Dave Otto | Dave Otto | Darren Holmes | | 757 | 728 | 29 |
| 1991-10-02 | @ CLE | 158 | W 11-4 | - | | 3,785 | Chris Bosio | Doug Jones | Chuck Crim | Doug Jones | Darren Holmes | 768 | 732 | 36 |
| 1991-10-03 | @ CLE | 159 | W 9-3 | - | | 5,050 | Jaime Navarro | Greg Swindell | Jaime Navarro | Greg Swindell | | 777 | 735 | 42 |
| 1991-10-04 | @ BOS | 160 | W 3-2 | - | | 31,894 | Cal Eldred | Mike Gardiner | Cal Eldred | Mike Gardiner | Doug Henry | 780 | 737 | 43 |
| 1991-10-05 | @ BOS | 161 | W 13-4 | - | | 32,185 | Dan Plesac | Tom Bolton | Mike Ignasiak | Tom Bolton | | 793 | 741 | 52 |
| 1991-10-06 | @ BOS | 162 | W 6-3 | - | | 31,837 | Bill Wegman | Roger Clemens | Julio Machado | Roger Clemens | Doug Henry | 799 | 744 | 55 |