| 1991-04-08 | vs NYA | 1 | W 6-4 | 1-0 | 2 | 47,382 | Frank Tanana | Tim Leary | Paul Gibson | Greg Cadaret | Mike Henneman | 6 | 4 | 2 |
| 1991-04-10 | vs NYA | 2 | L 0-4 | 1-1 | 3 | 7,842 | Walt Terrell | Scott Sanderson | Scott Sanderson | Walt Terrell | | 6 | 8 | -2 |
| 1991-04-11 | vs NYA | 3 | W 11-5 | 2-1 | 2 | 8,392 | Bill Gullickson | Dave Eiland | Paul Gibson | John Habyan | | 17 | 13 | 4 |
| 1991-04-12 | vs CHA | 4 | L 1-4 | 2-2 | 3 | 10,847 | Steve Searcy | Alex Fernandez | Alex Fernandez | Steve Searcy | Bobby Thigpen | 18 | 17 | 1 |
| 1991-04-13 | vs CHA | 5 | L 1-4 | 2-3 | 6 | 10,673 | Frank Tanana | Jack McDowell | Jack McDowell | Frank Tanana | | 19 | 21 | -2 |
| 1991-04-15 | vs TOR | 6 | L 3-4 | 2-4 | 5 | 9,632 | Walt Terrell | Todd Stottlemyre | Todd Stottlemyre | Walt Terrell | Duane Ward | 22 | 25 | -3 |
| 1991-04-16 | vs TOR | 7 | W 6-2 | 3-4 | 4 | 10,791 | Bill Gullickson | David Wells | Bill Gullickson | David Wells | Mike Henneman | 28 | 27 | 1 |
| 1991-04-17 | vs TOR | 8 | W 5-4 | 4-4 | 3 | 16,355 | Steve Searcy | Denis Boucher | Mike Henneman | Duane Ward | | 33 | 31 | 2 |
| 1991-04-18 | @ CHA | 9 | W 16-0 | 5-4 | 2 | 42,191 | Frank Tanana | Jack McDowell | Frank Tanana | Jack McDowell | | 49 | 31 | 18 |
| 1991-04-20 | @ CHA | 10 | W 2-1 | 6-4 | 2 | 36,420 | Walt Terrell | Greg Hibbard | Mike Henneman | Scott Radinsky | Jerry Gleaton | 51 | 32 | 19 |
| 1991-04-21 | @ CHA | 11 | L 4-5 | 6-5 | 3 | 29,776 | Bill Gullickson | Melido Perez | Brian Drahman | Paul Gibson | | 55 | 37 | 18 |
| 1991-04-22 | @ NYA | 12 | W 10-5 | 7-5 | 2 | 12,938 | Steve Searcy | Andy Hawkins | Jerry Gleaton | Greg Cadaret | | 65 | 42 | 23 |
| 1991-04-23 | @ NYA | 13 | L 0-5 | 7-6 | 2 | 14,789 | Frank Tanana | Dave Eiland | Dave Eiland | Frank Tanana | | 65 | 47 | 18 |
| 1991-04-25 | @ TOR | 14 | L 2-3 | 7-7 | 3 | 49,688 | Dan Petry | Jimmy Key | Jimmy Key | Dan Petry | Duane Ward | 67 | 50 | 17 |
| 1991-04-26 | @ TOR | 15 | L 4-5 | 7-8 | 4 | 50,170 | Walt Terrell | Todd Stottlemyre | Todd Stottlemyre | Walt Terrell | Duane Ward | 71 | 55 | 16 |
| 1991-04-27 | @ TOR | 16 | W 4-2 | 8-8 | 4 | 50,211 | Bill Gullickson | David Wells | Bill Gullickson | David Wells | Mike Henneman | 75 | 57 | 18 |
| 1991-04-28 | @ TOR | 17 | L 6-9 | 8-9 | 4 | 50,134 | Frank Tanana | Denis Boucher | Mike Timlin | Mark Leiter | Duane Ward | 81 | 66 | 15 |
| 1991-04-29 | @ KCA | 18 | W 3-1 | 9-9 | 3 | 20,477 | Steve Searcy | Bret Saberhagen | Steve Searcy | Bret Saberhagen | Paul Gibson | 84 | 67 | 17 |
| 1991-04-30 | @ KCA | 19 | W 13-7 | 10-9 | 3 | 18,204 | Walt Terrell | Luis Aquino | Mark Leiter | Jeff Montgomery | Mike Henneman | 97 | 74 | 23 |
| 1991-05-01 | @ KCA | 20 | W 6-4 | 11-9 | 2 | 18,536 | Bill Gullickson | Mike Boddicker | Bill Gullickson | Mike Boddicker | Mike Henneman | 103 | 78 | 25 |
| 1991-05-03 | vs TEX | 21 | W 7-6 | 12-9 | 4 | 13,337 | Frank Tanana | Scott Chiamparino | Mike Henneman | Brad Arnsberg | | 110 | 84 | 26 |
| 1991-05-04 | vs TEX | 22 | L 5-6 | 12-10 | 4 | 16,051 | Dan Petry | Bobby Witt | Rich Gossage | Jerry Gleaton | | 115 | 90 | 25 |
| 1991-05-05 | vs TEX | 23 | W 8-7 | 13-10 | 3 | 14,619 | Walt Terrell | Kevin Brown | Walt Terrell | Kevin Brown | | 123 | 97 | 26 |
| 1991-05-07 | vs KCA | 24 | W 5-4 | 14-10 | 2 | 11,506 | Bill Gullickson | Mike Boddicker | Bill Gullickson | Kevin Appier | Paul Gibson | 128 | 101 | 27 |
| 1991-05-08 | vs KCA | 25 | W 7-3 | 15-10 | 2 | 14,495 | Frank Tanana | Storm Davis | Frank Tanana | Storm Davis | | 135 | 104 | 31 |
| 1991-05-09 | @ MIN | 26 | W 3-0 | 16-10 | 2 | 10,765 | Dan Petry | Kevin Tapani | Dan Petry | Kevin Tapani | Paul Gibson | 138 | 104 | 34 |
| 1991-05-10 | @ MIN | 27 | L 2-5 | 16-11 | 2 | 16,012 | Walt Terrell | Mark Guthrie | Mark Guthrie | Walt Terrell | Rick Aguilera | 140 | 109 | 31 |
| 1991-05-11 | @ MIN | 28 | L 4-5 | 16-12 | 3 | 23,063 | Steve Searcy | Allan Anderson | Carl Willis | Mike Henneman | Rick Aguilera | 144 | 114 | 30 |
| 1991-05-12 | @ MIN | 29 | L 3-8 | 16-13 | 3 | 13,189 | Bill Gullickson | Scott Erickson | Scott Erickson | Bill Gullickson | | 147 | 122 | 25 |
| 1991-05-13 | @ TEX | 30 | L 1-8 | 16-14 | 3 | 26,544 | John Cerutti | Nolan Ryan | John Barfield | John Cerutti | | 148 | 130 | 18 |
| 1991-05-14 | @ TEX | 31 | L 3-5 | 16-15 | 3 | 14,507 | Dan Petry | Scott Chiamparino | Scott Chiamparino | Dan Petry | Jeff Russell | 151 | 135 | 16 |
| 1991-05-15 | @ TEX | 32 | L 4-5 | 16-16 | 3 | 18,581 | Walt Terrell | Bobby Witt | Rich Gossage | Steve Searcy | | 155 | 140 | 15 |
| 1991-05-17 | vs MIN | 33 | L 1-8 | 16-17 | 3 | 13,673 | Bill Gullickson | Scott Erickson | Scott Erickson | Bill Gullickson | Steve Bedrosian | 156 | 148 | 8 |
| 1991-05-18 | vs MIN | 34 | L 1-4 | 16-18 | 3 | 31,432 | Frank Tanana | Mark Guthrie | Mark Guthrie | Frank Tanana | Rick Aguilera | 157 | 152 | 5 |
| 1991-05-19 | vs MIN | 35 | W 8-3 | 17-18 | 3 | 17,148 | Dan Petry | Jack Morris | Dan Petry | Jack Morris | | 165 | 155 | 10 |
| 1991-05-20 | vs BAL | 36 | W 11-5 | 18-18 | 3 | 22,231 | Walt Terrell | Bob Milacki | Jerry Gleaton | Bob Milacki | | 176 | 160 | 16 |
| 1991-05-21 | vs BAL | 37 | L 4-5 | 18-19 | 3 | 11,339 | John Cerutti | Jose Mesa | Mike Flanagan | Paul Gibson | Gregg Olson | 180 | 165 | 15 |
| 1991-05-22 | vs BAL | 38 | W 9-5 | 19-19 | 3 | 13,440 | Bill Gullickson | Ben McDonald | Bill Gullickson | Ben McDonald | | 189 | 170 | 19 |
| 1991-05-23 | vs BOS | 39 | W 5-3 | 20-19 | 3 | 14,744 | Frank Tanana | Roger Clemens | Mike Henneman | Roger Clemens | Paul Gibson | 194 | 173 | 21 |
| 1991-05-24 | vs BOS | 40 | L 9-10 | 20-20 | 3 | 16,546 | Dan Petry | Tom Bolton | Tom Bolton | Dan Petry | Jeff Reardon | 203 | 183 | 20 |
| 1991-05-25 | vs BOS | 41 | W 3-2 | 21-20 | 3 | 19,179 | Walt Terrell | Matt Young | Walt Terrell | Matt Young | Mike Henneman | 206 | 185 | 21 |
| 1991-05-26 | vs BOS | 42 | W 9-4 | 22-20 | 3 | 24,821 | John Cerutti | Dana Kiecker | Mark Leiter | Dana Kiecker | Paul Gibson | 215 | 189 | 26 |
| 1991-05-27 | @ MIL | 43 | W 15-9 | 23-20 | 3 | 27,667 | Bill Gullickson | Kevin Brown | Mike Henneman | Chuck Crim | | 230 | 198 | 32 |
| 1991-05-28 | @ MIL | 44 | L 2-15 | 23-21 | 3 | 12,981 | Frank Tanana | Don August | Don August | Frank Tanana | | 232 | 213 | 19 |
| 1991-05-29 | @ MIL | 45 | L 2-6 | 23-22 | 3 | 21,673 | Walt Terrell | Jaime Navarro | Jaime Navarro | Walt Terrell | | 234 | 219 | 15 |
| 1991-05-31 | @ CLE | 46 | L 9-11 | 23-23 | 3 | 22,658 | Kevin Ritz | Eric King | Sergio Valdez | Kevin Ritz | Shawn Hillegas | 243 | 230 | 13 |
| 1991-06-01 | @ CLE | 47 | L 1-3 | 23-24 | 3 | 22,535 | Bill Gullickson | Greg Swindell | Greg Swindell | Bill Gullickson | | 244 | 233 | 11 |
| 1991-06-02 | @ CLE | 48 | L 2-3 | 23-25 | 3 | 14,164 | Frank Tanana | Tom Candiotti | Tom Candiotti | Frank Tanana | Doug Jones | 246 | 236 | 10 |
| 1991-06-03 | @ CLE | 49 | L 0-2 | 23-26 | 4 | 6,832 | Walt Terrell | Charles Nagy | Charles Nagy | Walt Terrell | Shawn Hillegas | 246 | 238 | 8 |
| 1991-06-04 | vs SEA | 50 | L 6-8 | 23-27 | 4 | 11,993 | John Cerutti | Brian Holman | Brian Holman | John Cerutti | Michael Jackson | 252 | 246 | 6 |
| 1991-06-05 | vs SEA | 51 | W 7-1 | 24-27 | 3 | 12,609 | Kevin Ritz | Rich DeLucia | Jerry Gleaton | Rich DeLucia | Paul Gibson | 259 | 247 | 12 |
| 1991-06-06 | vs SEA | 52 | W 5-4 | 25-27 | 3 | 15,600 | Bill Gullickson | Scott Bankhead | Bill Gullickson | Scott Bankhead | Mike Henneman | 264 | 251 | 13 |
| 1991-06-07 | @ CAL | 53 | W 5-0 | 26-27 | 3 | 49,977 | Frank Tanana | Fernando Valenzuela | Frank Tanana | Fernando Valenzuela | | 269 | 251 | 18 |
| 1991-06-08 | @ CAL | 54 | W 4-3 | 27-27 | 3 | 59,502 | Walt Terrell | Jim Abbott | Walt Terrell | Jim Abbott | Mike Henneman | 273 | 254 | 19 |
| 1991-06-09 | @ CAL | 55 | L 3-7 | 27-28 | 3 | 42,677 | Dan Gakeler | Chuck Finley | Chuck Finley | Dan Gakeler | | 276 | 261 | 15 |
| 1991-06-10 | @ OAK | 56 | L 6-12 | 27-29 | 3 | 22,499 | Kevin Ritz | Dave Stewart | Johnny Guzman | Mike Henneman | | 282 | 273 | 9 |
| 1991-06-11 | @ OAK | 57 | W 5-1 | 28-29 | 3 | 27,014 | Bill Gullickson | Andy Hawkins | Bill Gullickson | Andy Hawkins | Mike Henneman | 287 | 274 | 13 |
| 1991-06-12 | @ OAK | 58 | L 1-3 | 28-30 | 3 | 30,404 | Frank Tanana | Mike Moore | Mike Moore | Frank Tanana | Dennis Eckersley | 288 | 277 | 11 |
| 1991-06-13 | @ SEA | 59 | L 5-6 | 28-31 | 3 | 15,557 | Walt Terrell | Rich DeLucia | Bill Swift | Paul Gibson | Michael Jackson | 293 | 283 | 10 |
| 1991-06-14 | @ SEA | 60 | W 5-1 | 29-31 | 3 | 20,616 | Dan Gakeler | Brian Holman | Dan Gakeler | Brian Holman | | 298 | 284 | 14 |
| 1991-06-15 | @ SEA | 61 | L 2-15 | 29-32 | 3 | 27,417 | Kevin Ritz | Randy Johnson | Randy Johnson | Kevin Ritz | Bill Swift | 300 | 299 | 1 |
| 1991-06-16 | @ SEA | 62 | W 7-3 | 30-32 | 3 | 53,287 | Bill Gullickson | Pat Rice | Bill Gullickson | Pat Rice | | 307 | 302 | 5 |
| 1991-06-18 | vs OAK | 63 | W 2-0 | 31-32 | 3 | 23,664 | Frank Tanana | Bob Welch | Frank Tanana | Bob Welch | Mike Henneman | 309 | 302 | 7 |
| 1991-06-19 | vs OAK | 64 | L 4-5 | 31-33 | 3 | 22,658 | Walt Terrell | Andy Hawkins | Gene Nelson | Walt Terrell | Dennis Eckersley | 313 | 307 | 6 |
| 1991-06-20 | vs CAL | 65 | L 5-7 | 31-34 | 3 | 13,744 | Dan Gakeler | Chuck Finley | Joe Grahe | Paul Gibson | Bryan Harvey | 318 | 314 | 4 |
| 1991-06-21 | vs CAL | 66 | W 9-2 | 32-34 | 3 | 27,094 | Bill Gullickson | Kirk McCaskill | Bill Gullickson | Kirk McCaskill | | 327 | 316 | 11 |
| 1991-06-22 | vs CAL | 67 | L 3-10 | 32-35 | 3 | 21,809 | Kevin Ritz | Mark Langston | Mark Langston | Kevin Ritz | | 330 | 326 | 4 |
| 1991-06-23 | vs CAL | 68 | W 4-3 | 33-35 | 3 | 23,785 | Frank Tanana | Jim Abbott | Paul Gibson | Jeff Robinson | | 334 | 329 | 5 |
| 1991-06-25 | vs MIL | 69 | L 3-11 | 33-36 | 3 | 13,765 | Walt Terrell | Bill Wegman | Bill Wegman | Walt Terrell | | 337 | 340 | -3 |
| 1991-06-26 | vs MIL | 70 | W 8-7 | 34-36 | 3 | 13,355 | Dan Gakeler | Jaime Navarro | John Cerutti | Julio Machado | | 345 | 347 | -2 |
| 1991-06-27 | vs MIL | 71 | L 3-9 | 34-37 | 3 | 13,606 | Bill Gullickson | Chris Bosio | Chris Bosio | Bill Gullickson | | 348 | 356 | -8 |
| 1991-06-28 | vs CLE | 72 | W 7-1 | 35-37 | 3 | 16,991 | Frank Tanana | Denis Boucher | Frank Tanana | Denis Boucher | | 355 | 357 | -2 |
| 1991-06-29 | vs CLE | 73 | W 9-4 | 36-37 | 3 | 39,091 | Rusty Meacham | Charles Nagy | Rusty Meacham | Charles Nagy | Mike Henneman | 364 | 361 | 3 |
| 1991-06-30 | vs CLE | 74 | W 4-1 | 37-37 | 3 | 24,640 | Walt Terrell | Rod Nichols | Walt Terrell | Rod Nichols | Mark Leiter | 368 | 362 | 6 |
| 1991-07-01 | @ BAL | 75 | L 2-10 | 37-38 | 3 | 28,835 | Dan Gakeler | Ben McDonald | Ben McDonald | Dan Gakeler | | 370 | 372 | -2 |
| 1991-07-02 | @ BAL | 76 | W 4-3 | 38-38 | 3 | 30,898 | Bill Gullickson | Jeff Ballard | Bill Gullickson | Jeff Ballard | Mike Henneman | 374 | 375 | -1 |
| 1991-07-03 | @ BAL | 77 | W 8-2 | 39-38 | 3 | 46,702 | Frank Tanana | Bob Milacki | Frank Tanana | Bob Milacki | | 382 | 377 | 5 |
| 1991-07-04 | @ BOS | 78 | W 6-1 | 40-38 | 3 | 33,611 | Rusty Meacham | Danny Darwin | Rusty Meacham | Danny Darwin | | 388 | 378 | 10 |
| 1991-07-05 | @ BOS | 79 | L 1-10 | 40-39 | 3 | 33,997 | Walt Terrell | Kevin Morton | Kevin Morton | Walt Terrell | | 389 | 388 | 1 |
| 1991-07-06 | @ BOS | 80 | L 4-7 | 40-40 | 3 | 34,440 | Dan Gakeler | Roger Clemens | Roger Clemens | Paul Gibson | Jeff Reardon | 393 | 395 | -2 |
| 1991-07-07 | @ BOS | 81 | W 7-6 | 41-40 | 3 | 33,648 | Bill Gullickson | Tom Bolton | Bill Gullickson | Tom Bolton | John Cerutti | 400 | 401 | -1 |
| 1991-07-11 | vs KCA | 82 | L 5-9 | 41-41 | 3 | 18,101 | Dan Gakeler | Kevin Appier | Kevin Appier | Dan Gakeler | | 405 | 410 | -5 |
| 1991-07-12 | vs KCA | 83 | W 6-3 | 42-41 | 3 | 23,737 | Frank Tanana | Mark Gubicza | Paul Gibson | Mike Magnante | Mike Henneman | 411 | 413 | -2 |
| 1991-07-13 | vs KCA | 84 | W 8-5 | 43-41 | 2 | 38,739 | Walt Terrell | Bret Saberhagen | Walt Terrell | Bret Saberhagen | | 419 | 418 | 1 |
| 1991-07-14 | vs KCA | 85 | L 4-18 | 43-42 | 3 | 33,202 | Bill Gullickson | Tom Gordon | Tom Gordon | Bill Gullickson | Luis Aquino | 423 | 436 | -13 |
| 1991-07-15 | vs TEX | 86 | W 8-7 | 44-42 | 2 | 14,365 | Rusty Meacham | Gerald Alexander | Mike Henneman | Mike Jeffcoat | | 431 | 443 | -12 |
| 1991-07-16 | vs TEX | 87 | W 6-5 | 45-42 | 2 | 16,662 | Mark Leiter | Kevin Brown | Mike Henneman | Kevin Brown | | 437 | 448 | -11 |
| 1991-07-17 | vs TEX | 88 | W 6-4 | 46-42 | 2 | 25,450 | Scott Aldred | Jose Guzman | Walt Terrell | Wayne Rosenthal | | 443 | 452 | -9 |
| 1991-07-19 | @ KCA | 89 | W 17-0 | 47-42 | 2 | 30,587 | Bill Gullickson | Tom Gordon | Bill Gullickson | Tom Gordon | | 460 | 452 | 8 |
| 1991-07-20 | @ KCA | 90 | L 4-8 | 47-43 | 2 | 31,057 | Rusty Meacham | Mike Boddicker | Mike Boddicker | Rusty Meacham | Luis Aquino | 464 | 460 | 4 |
| 1991-07-21 | @ KCA | 91 | L 4-8 | 47-44 | 2 | 27,759 | Mark Leiter | Kevin Appier | Kevin Appier | Mark Leiter | | 468 | 468 | 0 |
| 1991-07-23 | vs MIN | 92 | W 6-3 | 48-44 | 2 | 21,976 | Frank Tanana | Jack Morris | Frank Tanana | Allan Anderson | Mike Henneman | 474 | 471 | 3 |
| 1991-07-24 | vs MIN | 93 | W 6-3 | 49-44 | 2 | 18,391 | Bill Gullickson | David West | Bill Gullickson | David West | Mike Henneman | 480 | 474 | 6 |
| 1991-07-25 | vs MIN | 94 | L 3-9 | 49-45 | 2 | 20,007 | Scott Aldred | Scott Erickson | Scott Erickson | Scott Aldred | Steve Bedrosian | 483 | 483 | 0 |
| 1991-07-26 | @ TEX | 95 | W 3-2 | 50-45 | 2 | 40,383 | Walt Terrell | Kevin Brown | Mike Henneman | Jeff Russell | | 486 | 485 | 1 |
| 1991-07-27 | @ TEX | 96 | L 5-8 | 50-46 | 2 | 40,112 | Mark Leiter | John Barfield | Gerald Alexander | John Kiely | Kenny Rogers | 491 | 493 | -2 |
| 1991-07-28 | @ TEX | 97 | L 6-10 | 50-47 | 2 | 40,411 | Frank Tanana | Nolan Ryan | Nolan Ryan | Frank Tanana | | 497 | 503 | -6 |
| 1991-07-29 | @ MIN | 98 | L 3-6 | 50-48 | 2 | 35,599 | Bill Gullickson | David West | David West | Bill Gullickson | Rick Aguilera | 500 | 509 | -9 |
| 1991-07-30 | @ MIN | 99 | L 7-9 | 50-49 | 2 | 42,035 | Scott Aldred | Scott Erickson | Carl Willis | John Cerutti | | 507 | 518 | -11 |
| 1991-07-31 | vs CAL | 100 | W 3-1 | 51-49 | 2 | 17,626 | Walt Terrell | Mark Langston | Walt Terrell | Mark Langston | | 510 | 519 | -9 |
| 1991-08-01 | vs CAL | 101 | W 5-3 | 52-49 | 2 | 25,092 | Mark Leiter | Mike Fetters | Mark Leiter | Mike Fetters | Mike Henneman | 515 | 522 | -7 |
| 1991-08-02 | vs NYA | 102 | W 7-3 | 53-49 | 2 | 25,578 | Frank Tanana | Scott Kamieniecki | Frank Tanana | Scott Kamieniecki | | 522 | 525 | -3 |
| 1991-08-03 | vs NYA | 103 | W 7-6 | 54-49 | 2 | 30,927 | Bill Gullickson | Jeff Johnson | Bill Gullickson | Jeff Johnson | Mike Henneman | 529 | 531 | -2 |
| 1991-08-04 | vs NYA | 104 | W 8-7 | 55-49 | 2 | 30,022 | Scott Aldred | Wade Taylor | Mike Henneman | Steve Farr | | 537 | 538 | -1 |
| 1991-08-05 | vs NYA | 105 | L 5-7 | 55-50 | 2 | 25,938 | Walt Terrell | Scott Sanderson | Scott Sanderson | Walt Terrell | Lee Guetterman | 542 | 545 | -3 |
| 1991-08-06 | @ TOR | 106 | L 1-2 | 55-51 | 2 | 50,305 | John Cerutti | Jimmy Key | Jimmy Key | John Cerutti | Tom Henke | 543 | 547 | -4 |
| 1991-08-07 | @ TOR | 107 | L 2-5 | 55-52 | 2 | 50,324 | Frank Tanana | Juan Guzman | Juan Guzman | Frank Tanana | Tom Henke | 545 | 552 | -7 |
| 1991-08-08 | @ TOR | 108 | W 4-0 | 56-52 | 2 | 50,307 | Bill Gullickson | Tom Candiotti | Paul Gibson | Tom Henke | | 549 | 552 | -3 |
| 1991-08-10 | @ NYA | 109 | W 5-1 | 58-52 | 2 | 0 | Mark Leiter | Scott Sanderson | Mark Leiter | Scott Sanderson | | 554 | 553 | 1 |
| 1991-08-10 | @ NYA | 110 | W 4-0 | 58-52 | 2 | 28,744 | Walt Terrell | Wade Taylor | Walt Terrell | Wade Taylor | | 558 | 553 | 5 |
| 1991-08-11 | @ NYA | 111 | L 6-12 | 58-54 | 2 | 0 | John Cerutti | Greg Cadaret | Greg Cadaret | Dan Gakeler | | 564 | 565 | -1 |
| 1991-08-11 | @ NYA | 112 | L 8-10 | 58-54 | 2 | 34,733 | Scott Aldred | Tim Leary | Steve Farr | Paul Gibson | | 572 | 575 | -3 |
| 1991-08-13 | vs CHA | 113 | W 11-9 | 60-54 | 2 | 0 | Frank Tanana | Alex Fernandez | Frank Tanana | Alex Fernandez | | 583 | 584 | -1 |
| 1991-08-13 | vs CHA | 114 | W 4-3 | 60-54 | 2 | 29,339 | Bill Gullickson | Greg Hibbard | Bill Gullickson | Greg Hibbard | Mike Henneman | 587 | 587 | 0 |
| 1991-08-14 | vs CHA | 115 | L 8-9 | 60-55 | 2 | 21,114 | Walt Terrell | Charlie Hough | Scott Radinsky | Paul Gibson | Bobby Thigpen | 595 | 596 | -1 |
| 1991-08-15 | vs CHA | 116 | W 6-4 | 61-55 | 2 | 20,247 | Mark Leiter | Jeff Carter | Mark Leiter | Jeff Carter | Mike Henneman | 601 | 600 | 1 |
| 1991-08-16 | vs TOR | 117 | W 5-2 | 62-55 | 2 | 43,186 | John Cerutti | Jimmy Key | John Cerutti | Jimmy Key | Dan Gakeler | 606 | 602 | 4 |
| 1991-08-17 | vs TOR | 118 | L 5-7 | 62-56 | 2 | 46,634 | Scott Aldred | Juan Guzman | Bob Macdonald | Scott Aldred | Tom Henke | 611 | 609 | 2 |
| 1991-08-18 | vs TOR | 119 | L 2-4 | 62-57 | 2 | 48,724 | Bill Gullickson | Tom Candiotti | Tom Candiotti | Jeff Kaiser | Tom Henke | 613 | 613 | 0 |
| 1991-08-19 | @ CHA | 120 | W 3-2 | 63-57 | 2 | 42,406 | Frank Tanana | Alex Fernandez | Frank Tanana | Alex Fernandez | Paul Gibson | 616 | 615 | 1 |
| 1991-08-20 | @ CHA | 121 | W 5-0 | 64-57 | 2 | 34,404 | Walt Terrell | Charlie Hough | Walt Terrell | Charlie Hough | | 621 | 615 | 6 |
| 1991-08-21 | @ CHA | 122 | W 12-9 | 65-57 | 2 | 41,754 | Mark Leiter | Wilson Alvarez | Mark Leiter | Wilson Alvarez | | 633 | 624 | 9 |
| 1991-08-23 | vs SEA | 123 | W 8-6 | 66-57 | 2 | 30,214 | Bill Gullickson | Brian Holman | Bill Gullickson | Brian Holman | Jeff Kaiser | 641 | 630 | 11 |
| 1991-08-24 | vs SEA | 124 | W 7-2 | 67-57 | 1 | 42,135 | Frank Tanana | Randy Johnson | Frank Tanana | Randy Johnson | | 648 | 632 | 16 |
| 1991-08-25 | vs SEA | 125 | W 4-3 | 68-57 | 1 | 29,480 | Walt Terrell | Erik Hanson | Walt Terrell | Mike Schooler | | 652 | 635 | 17 |
| 1991-08-26 | @ CAL | 126 | W 5-1 | 69-57 | 1 | 29,104 | Mark Leiter | Joe Grahe | Mark Leiter | Joe Grahe | Dan Gakeler | 657 | 636 | 21 |
| 1991-08-27 | @ CAL | 127 | L 2-4 | 69-58 | 2 | 27,494 | John Cerutti | Chuck Finley | Chuck Finley | John Cerutti | Bryan Harvey | 659 | 640 | 19 |
| 1991-08-28 | @ CAL | 128 | L 0-1 | 69-59 | 2 | 24,882 | Bill Gullickson | Jim Abbott | Jim Abbott | Bill Gullickson | Bryan Harvey | 659 | 641 | 18 |
| 1991-08-30 | @ OAK | 129 | L 3-6 | 69-60 | 2 | 31,774 | Frank Tanana | Ron Darling | Dennis Eckersley | Jerry Gleaton | | 662 | 647 | 15 |
| 1991-08-31 | @ OAK | 130 | L 8-9 | 69-61 | 2 | 43,726 | Walt Terrell | Mike Moore | Dennis Eckersley | John Cerutti | | 670 | 656 | 14 |
| 1991-09-01 | @ OAK | 131 | W 5-2 | 70-61 | 2 | 33,173 | Mark Leiter | Bob Welch | Mark Leiter | Bob Welch | Jerry Gleaton | 675 | 658 | 17 |
| 1991-09-02 | @ SEA | 132 | W 12-5 | 71-61 | 2 | 20,208 | Bill Gullickson | Rich DeLucia | Bill Gullickson | Rich DeLucia | Paul Gibson | 687 | 663 | 24 |
| 1991-09-03 | @ SEA | 133 | L 0-1 | 71-62 | 2 | 11,441 | Scott Aldred | Brian Holman | Brian Holman | Scott Aldred | Bill Swift | 687 | 664 | 23 |
| 1991-09-05 | vs OAK | 134 | L 1-4 | 71-63 | 2 | 16,953 | Frank Tanana | Mike Moore | Mike Moore | Frank Tanana | Dennis Eckersley | 688 | 668 | 20 |
| 1991-09-06 | vs OAK | 135 | W 11-2 | 72-63 | 2 | 24,797 | Walt Terrell | Bob Welch | Walt Terrell | Bob Welch | | 699 | 670 | 29 |
| 1991-09-07 | vs OAK | 136 | L 1-3 | 72-64 | 2 | 34,737 | Mark Leiter | Joe Slusarski | Joe Slusarski | Mark Leiter | Dennis Eckersley | 700 | 673 | 27 |
| 1991-09-08 | vs OAK | 137 | L 4-7 | 72-65 | 3 | 28,873 | Bill Gullickson | Dave Stewart | Dave Stewart | Bill Gullickson | Dennis Eckersley | 704 | 680 | 24 |
| 1991-09-10 | vs BOS | 138 | L 0-4 | 72-66 | 3 | 16,859 | Frank Tanana | Roger Clemens | Roger Clemens | Frank Tanana | | 704 | 684 | 20 |
| 1991-09-11 | vs BOS | 139 | W 8-2 | 73-66 | 3 | 16,710 | Walt Terrell | Matt Young | Walt Terrell | Matt Young | | 712 | 686 | 26 |
| 1991-09-12 | @ MIL | 140 | L 0-7 | 73-67 | 3 | 9,835 | Mark Leiter | Chris Bosio | Chris Bosio | Mark Leiter | | 712 | 693 | 19 |
| 1991-09-13 | @ MIL | 141 | W 3-2 | 74-67 | 3 | 14,554 | Bill Gullickson | Jaime Navarro | Bill Gullickson | Mark Lee | Jeff Kaiser | 715 | 695 | 20 |
| 1991-09-14 | @ MIL | 142 | W 6-4 | 75-67 | 3 | 26,644 | Scott Aldred | Dan Plesac | Scott Aldred | Dan Plesac | | 721 | 699 | 22 |
| 1991-09-15 | @ MIL | 143 | L 3-5 | 75-68 | 3 | 13,296 | Frank Tanana | Bill Wegman | Bill Wegman | Frank Tanana | Doug Henry | 724 | 704 | 20 |
| 1991-09-17 | @ CLE | 144 | L 1-3 | 75-69 | 3 | 5,749 | Walt Terrell | Doug Jones | Doug Jones | Walt Terrell | Steve Olin | 725 | 707 | 18 |
| 1991-09-18 | @ CLE | 145 | L 2-3 | 75-70 | 3 | 4,976 | Bill Gullickson | Charles Nagy | Charles Nagy | Bill Gullickson | | 727 | 710 | 17 |
| 1991-09-20 | vs MIL | 146 | L 5-8 | 75-71 | 3 | 13,966 | Mark Leiter | Dan Plesac | Dan Plesac | Mark Leiter | Doug Henry | 732 | 718 | 14 |
| 1991-09-21 | vs MIL | 147 | L 2-5 | 75-72 | 3 | 18,317 | Frank Tanana | Bill Wegman | Bill Wegman | Frank Tanana | Doug Henry | 734 | 723 | 11 |
| 1991-09-22 | vs MIL | 148 | L 5-9 | 75-73 | 3 | 15,752 | Walt Terrell | Chris Bosio | Chris Bosio | Walt Terrell | | 739 | 732 | 7 |
| 1991-09-23 | vs CLE | 149 | W 2-1 | 76-73 | 3 | 9,453 | Bill Gullickson | Eric King | Bill Gullickson | Eric King | Mike Henneman | 741 | 733 | 8 |
| 1991-09-24 | vs CLE | 150 | W 7-2 | 77-73 | 3 | 10,074 | Scott Aldred | Charles Nagy | Scott Aldred | Charles Nagy | | 748 | 735 | 13 |
| 1991-09-25 | vs CLE | 151 | L 4-6 | 77-74 | 3 | 9,563 | Mark Leiter | Doug Jones | Doug Jones | Mark Leiter | Steve Olin | 752 | 741 | 11 |
| 1991-09-26 | vs CLE | 152 | W 6-5 | 78-74 | 3 | 9,914 | Frank Tanana | Dave Otto | John Cerutti | Dave Otto | Mike Henneman | 758 | 746 | 12 |
| 1991-09-27 | vs BAL | 153 | L 7-9 | 78-75 | 3 | 13,449 | Walt Terrell | Arthur Rhodes | Mark Williamson | Walt Terrell | Gregg Olson | 765 | 755 | 10 |
| 1991-09-28 | vs BAL | 154 | W 5-4 | 79-75 | 3 | 22,541 | Bill Gullickson | Mike Mussina | Mike Henneman | Gregg Olson | | 770 | 759 | 11 |
| 1991-09-29 | vs BAL | 155 | L 4-7 | 79-76 | 3 | 17,925 | Scott Aldred | Jose Mesa | Jose Mesa | Scott Aldred | Todd Frohwirth | 774 | 766 | 8 |
| 1991-09-30 | vs BAL | 156 | W 8-3 | 80-76 | 3 | 11,824 | Mark Leiter | Dave Johnson | Mark Leiter | Dave Johnson | | 782 | 769 | 13 |
| 1991-10-01 | @ BOS | 157 | W 8-5 | 81-76 | 3 | 31,942 | Frank Tanana | Roger Clemens | Frank Tanana | Roger Clemens | | 790 | 774 | 16 |
| 1991-10-02 | @ BOS | 158 | L 3-5 | 81-77 | 3 | 32,003 | Walt Terrell | Joe Hesketh | Joe Hesketh | Walt Terrell | Tony Fossas | 793 | 779 | 14 |
| 1991-10-03 | @ BOS | 159 | W 10-5 | 82-77 | 3 | 31,162 | Bill Gullickson | Kevin Morton | Bill Gullickson | Kevin Morton | | 803 | 784 | 19 |
| 1991-10-04 | @ BAL | 160 | W 4-2 | 83-77 | 3 | 47,983 | Scott Aldred | Mike Mussina | Dave Haas | Jim Poole | John Cerutti | 807 | 786 | 21 |
| 1991-10-05 | @ BAL | 161 | L 3-7 | 83-78 | 3 | 49,289 | Mark Leiter | Dave Johnson | Jim Poole | Mark Leiter | Mark Williamson | 810 | 793 | 17 |
| 1991-10-06 | @ BAL | 162 | W 7-1 | 84-78 | 3 | 50,700 | Frank Tanana | Bob Milacki | Frank Tanana | Bob Milacki | | 817 | 794 | 23 |