| 1990-04-09 | vs DET | 1 | W 5-2 | 1-0 | 2 | 35,199 | Roger Clemens | Jack Morris | Roger Clemens | Jack Morris | Lee Smith | 5 | 2 | 3 |
| 1990-04-10 | vs DET | 2 | W 4-2 | 2-0 | 2 | 15,352 | Mike Boddicker | Kevin Ritz | Mike Boddicker | Kevin Ritz | Lee Smith | 9 | 4 | 5 |
| 1990-04-11 | vs DET | 3 | W 3-2 | 3-0 | 1 | 15,369 | John Dopson | Jeff Robinson | Greg Harris | Jerry Gleaton | | 12 | 6 | 6 |
| 1990-04-12 | @ DET | 4 | L 7-11 | 3-1 | 2 | 44,906 | Mike Rochford | Frank Tanana | Urbano Lugo | Mike Rochford | | 19 | 17 | 2 |
| 1990-04-13 | vs MIL | 5 | L 5-9 | 3-2 | 2 | 22,731 | John Leister | Jaime Navarro | Chuck Crim | Rob Murphy | | 24 | 26 | -2 |
| 1990-04-14 | vs MIL | 6 | W 4-3 | 4-2 | 1 | 31,571 | Roger Clemens | Chris Bosio | Roger Clemens | Don August | Lee Smith | 28 | 29 | -1 |
| 1990-04-16 | vs MIL | 7 | L 0-18 | 4-3 | 3 | 35,478 | Mike Boddicker | Teddy Higuera | Teddy Higuera | Mike Boddicker | | 28 | 47 | -19 |
| 1990-04-17 | @ CHA | 8 | L 1-2 | 4-4 | 3 | 8,479 | John Dopson | Eric King | Barry Jones | Lee Smith | | 29 | 49 | -20 |
| 1990-04-18 | @ CHA | 9 | W 7-5 | 5-4 | 3 | 10,570 | Roger Clemens | Jack McDowell | Roger Clemens | Jack McDowell | Lee Smith | 36 | 54 | -18 |
| 1990-04-20 | @ MIL | 10 | L 0-5 | 5-5 | 4 | 15,334 | Mike Boddicker | Tom Filer | Tom Filer | Mike Boddicker | Chuck Crim | 36 | 59 | -23 |
| 1990-04-21 | @ MIL | 11 | L 0-2 | 5-6 | 4 | 19,391 | Eric Hetzel | Teddy Higuera | Teddy Higuera | Eric Hetzel | | 36 | 61 | -25 |
| 1990-04-22 | @ MIL | 12 | W 4-2 | 6-6 | 4 | 26,741 | John Dopson | Jaime Navarro | Lee Smith | Dan Plesac | | 40 | 63 | -23 |
| 1990-04-24 | vs CAL | 13 | W 4-2 | 7-6 | 3 | 24,362 | Roger Clemens | Mark Langston | Roger Clemens | Mark Langston | Jeff Reardon | 44 | 65 | -21 |
| 1990-04-25 | vs CAL | 14 | L 1-3 | 7-7 | 3 | 19,843 | Mike Boddicker | Kirk McCaskill | Kirk McCaskill | Mike Boddicker | Mark Eichhorn | 45 | 68 | -23 |
| 1990-04-26 | vs CAL | 15 | W 5-4 | 8-7 | 3 | 22,601 | Eric Hetzel | Jim Abbott | Lee Smith | Bryan Harvey | | 50 | 72 | -22 |
| 1990-04-27 | vs OAK | 16 | W 7-6 | 9-7 | 3 | 32,912 | Dana Kiecker | Scott Sanderson | Jeff Reardon | Gene Nelson | | 57 | 78 | -21 |
| 1990-04-28 | vs OAK | 17 | W 12-3 | 10-7 | 2 | 33,989 | Greg Harris | Curt Young | Greg Harris | Curt Young | | 69 | 81 | -12 |
| 1990-04-29 | vs OAK | 18 | L 0-1 | 10-8 | 2 | 33,237 | Roger Clemens | Dave Stewart | Dave Stewart | Roger Clemens | Dennis Eckersley | 69 | 82 | -13 |
| 1990-04-30 | vs SEA | 19 | W 11-0 | 11-8 | 2 | 18,540 | Mike Boddicker | Brian Holman | Mike Boddicker | Brian Holman | | 80 | 82 | -2 |
| 1990-05-01 | vs SEA | 20 | W 8-2 | 12-8 | 2 | 20,786 | Eric Hetzel | Randy Johnson | Eric Hetzel | Randy Johnson | | 88 | 84 | 4 |
| 1990-05-02 | vs SEA | 21 | L 2-9 | 12-9 | 2 | 23,977 | Greg Harris | Erik Hanson | Erik Hanson | Greg Harris | | 90 | 93 | -3 |
| 1990-05-04 | @ OAK | 22 | L 3-8 | 12-10 | 2 | 43,894 | Roger Clemens | Dave Stewart | Dave Stewart | Roger Clemens | | 93 | 101 | -8 |
| 1990-05-05 | @ OAK | 23 | W 5-1 | 13-10 | 2 | 41,850 | Mike Boddicker | Bob Welch | Mike Boddicker | Bob Welch | | 98 | 102 | -4 |
| 1990-05-06 | @ OAK | 24 | L 2-4 | 13-11 | 3 | 44,008 | Eric Hetzel | Curt Young | Curt Young | Eric Hetzel | Dennis Eckersley | 100 | 106 | -6 |
| 1990-05-07 | @ SEA | 25 | W 5-4 | 14-11 | 3 | 19,549 | Greg Harris | Erik Hanson | Greg Harris | Erik Hanson | Rob Murphy | 105 | 110 | -5 |
| 1990-05-08 | @ SEA | 26 | L 1-2 | 14-12 | 3 | 11,503 | Dana Kiecker | Matt Young | Bill Swift | Wes Gardner | | 106 | 112 | -6 |
| 1990-05-09 | @ SEA | 27 | W 4-1 | 15-12 | 3 | 14,192 | Roger Clemens | Gary Eave | Roger Clemens | Gary Eave | | 110 | 113 | -3 |
| 1990-05-11 | @ CAL | 28 | W 3-2 | 16-12 | 3 | 33,418 | Mike Boddicker | Jim Abbott | Mike Boddicker | Mark Eichhorn | Jeff Reardon | 113 | 115 | -2 |
| 1990-05-12 | @ CAL | 29 | W 7-1 | 17-12 | 2 | 50,755 | Greg Harris | Bert Blyleven | Greg Harris | Bert Blyleven | | 120 | 116 | 4 |
| 1990-05-13 | @ CAL | 30 | L 4-8 | 17-13 | 3 | 34,399 | Eric Hetzel | Chuck Finley | Chuck Finley | Dennis Lamp | Bryan Harvey | 124 | 124 | 0 |
| 1990-05-14 | @ KCA | 31 | L 5-9 | 17-14 | 3 | 32,763 | Roger Clemens | Storm Davis | Mark Davis | Jeff Reardon | | 129 | 133 | -4 |
| 1990-05-16 | @ KCA | 32 | W 7-1 | 18-14 | 3 | 21,887 | Mike Boddicker | Tom Gordon | Mike Boddicker | Tom Gordon | | 136 | 134 | 2 |
| 1990-05-18 | vs MIN | 33 | L 0-6 | 18-15 | 2 | 31,779 | Greg Harris | Tim Drummond | John Candelaria | Greg Harris | | 136 | 140 | -4 |
| 1990-05-19 | vs MIN | 34 | W 13-1 | 19-15 | 2 | 34,145 | Roger Clemens | Allan Anderson | Roger Clemens | Allan Anderson | | 149 | 141 | 8 |
| 1990-05-20 | vs MIN | 35 | L 4-5 | 19-16 | 2 | 33,141 | Eric Hetzel | Roy Smith | Roy Smith | Eric Hetzel | Rick Aguilera | 153 | 146 | 7 |
| 1990-05-21 | vs TEX | 36 | W 4-2 | 20-16 | 2 | 22,359 | Mike Boddicker | Brian Bohanon | Mike Boddicker | Gary Mielke | Jeff Reardon | 157 | 148 | 9 |
| 1990-05-22 | vs TEX | 37 | L 4-5 | 20-17 | 2 | 23,193 | Dana Kiecker | Bobby Witt | Bobby Witt | Dana Kiecker | Jeff Russell | 161 | 153 | 8 |
| 1990-05-23 | vs KCA | 38 | L 1-4 | 20-18 | 2 | 22,468 | Greg Harris | Bret Saberhagen | Bret Saberhagen | Greg Harris | | 162 | 157 | 5 |
| 1990-05-24 | vs KCA | 39 | W 4-1 | 21-18 | 2 | 31,982 | Roger Clemens | Mark Gubicza | Roger Clemens | Mark Gubicza | | 166 | 158 | 8 |
| 1990-05-25 | @ MIN | 40 | L 0-16 | 21-19 | 2 | 31,564 | Eric Hetzel | Roy Smith | Roy Smith | Eric Hetzel | | 166 | 174 | -8 |
| 1990-05-26 | @ MIN | 41 | L 5-6 | 21-20 | 2 | 32,048 | Mike Boddicker | Mark Guthrie | John Candelaria | Rob Murphy | Rick Aguilera | 171 | 180 | -9 |
| 1990-05-27 | @ MIN | 42 | L 1-3 | 21-21 | 3 | 28,173 | Dana Kiecker | Kevin Tapani | Kevin Tapani | Dana Kiecker | Rick Aguilera | 172 | 183 | -11 |
| 1990-05-28 | @ TEX | 43 | W 4-3 | 22-21 | 3 | 16,128 | Greg Harris | Mike Jeffcoat | Jerry Reed | Jeff Russell | Jeff Reardon | 176 | 186 | -10 |
| 1990-05-29 | @ TEX | 44 | W 2-1 | 23-21 | 3 | 27,185 | Roger Clemens | Charlie Hough | Roger Clemens | Charlie Hough | Jeff Reardon | 178 | 187 | -9 |
| 1990-05-30 | @ TEX | 45 | L 3-4 | 23-22 | 3 | 15,445 | Eric Hetzel | Kevin Brown | Kenny Rogers | Wes Gardner | | 181 | 191 | -10 |
| 1990-06-01 | @ CLE | 46 | W 4-3 | 24-22 | 2 | 23,833 | Mike Boddicker | Greg Swindell | Jerry Reed | Doug Jones | Jeff Reardon | 185 | 194 | -9 |
| 1990-06-02 | @ CLE | 47 | L 5-7 | 24-23 | 2 | 33,569 | Greg Harris | Buddy Black | Sergio Valdez | Rob Murphy | Doug Jones | 190 | 201 | -11 |
| 1990-06-03 | @ CLE | 48 | W 8-2 | 25-23 | 2 | 29,137 | Roger Clemens | John Farrell | Roger Clemens | John Farrell | | 198 | 203 | -5 |
| 1990-06-04 | vs NYA | 49 | W 5-3 | 26-23 | 1 | 32,125 | Dana Kiecker | Chuck Cary | Jeff Reardon | Jeff Robinson | | 203 | 206 | -3 |
| 1990-06-05 | vs NYA | 50 | W 9-8 | 27-23 | 1 | 32,919 | John Dopson | Andy Hawkins | Jeff Reardon | Eric Plunk | Jerry Reed | 212 | 214 | -2 |
| 1990-06-06 | vs NYA | 51 | W 4-1 | 28-23 | 1 | 33,385 | Mike Boddicker | Dave LaPoint | Mike Boddicker | Dave LaPoint | | 216 | 215 | 1 |
| 1990-06-07 | vs NYA | 52 | W 3-0 | 29-23 | 1 | 33,454 | Greg Harris | Tim Leary | Greg Harris | Tim Leary | Jeff Reardon | 219 | 215 | 4 |
| 1990-06-08 | vs CLE | 53 | W 4-3 | 30-23 | 1 | 34,222 | Roger Clemens | John Farrell | Roger Clemens | John Farrell | Jeff Reardon | 223 | 218 | 5 |
| 1990-06-09 | vs CLE | 54 | W 11-6 | 31-23 | 1 | 32,991 | Dana Kiecker | Sergio Valdez | Dana Kiecker | Sergio Valdez | Jerry Reed | 234 | 224 | 10 |
| 1990-06-10 | vs CLE | 55 | L 0-4 | 31-24 | 1 | 33,961 | Wes Gardner | Tom Candiotti | Tom Candiotti | Wes Gardner | Doug Jones | 234 | 228 | 6 |
| 1990-06-11 | vs CLE | 56 | L 3-4 | 31-25 | 1 | 30,404 | Mike Boddicker | Greg Swindell | Rudy Seanez | Dennis Lamp | Doug Jones | 237 | 232 | 5 |
| 1990-06-12 | @ NYA | 57 | L 4-5 | 31-26 | 2 | 31,706 | Greg Harris | Dave LaPoint | Lee Guetterman | Rob Murphy | Dave Righetti | 241 | 237 | 4 |
| 1990-06-13 | @ NYA | 58 | W 4-1 | 32-26 | 2 | 28,623 | Roger Clemens | Tim Leary | Roger Clemens | Tim Leary | Jeff Reardon | 245 | 238 | 7 |
| 1990-06-14 | @ NYA | 59 | L 1-3 | 32-27 | 2 | 27,073 | Dana Kiecker | Chuck Cary | Chuck Cary | Dana Kiecker | Dave Righetti | 246 | 241 | 5 |
| 1990-06-15 | @ BAL | 60 | W 4-3 | 33-27 | 2 | 45,503 | Wes Gardner | Pete Harnisch | Wes Gardner | Pete Harnisch | Jeff Reardon | 250 | 244 | 6 |
| 1990-06-16 | @ BAL | 61 | W 6-3 | 34-27 | 2 | 42,837 | Mike Boddicker | John Mitchell | Mike Boddicker | John Mitchell | | 256 | 247 | 9 |
| 1990-06-17 | @ BAL | 62 | W 6-5 | 35-27 | 2 | 47,534 | Greg Harris | Jeff Ballard | Greg Harris | Jeff Ballard | Rob Murphy | 262 | 252 | 10 |
| 1990-06-18 | @ BAL | 63 | L 2-7 | 35-28 | 2 | 31,582 | Roger Clemens | Dave Johnson | Dave Johnson | Roger Clemens | | 264 | 259 | 5 |
| 1990-06-19 | @ TOR | 64 | W 4-2 | 36-28 | 2 | 49,907 | Dana Kiecker | John Cerutti | Dana Kiecker | Duane Ward | Rob Murphy | 268 | 261 | 7 |
| 1990-06-20 | @ TOR | 65 | L 0-11 | 36-29 | 2 | 49,857 | Wes Gardner | Dave Stieb | Dave Stieb | Wes Gardner | Tom Henke | 268 | 272 | -4 |
| 1990-06-22 | vs BAL | 66 | W 4-3 | 37-29 | 2 | 34,711 | Mike Boddicker | Jeff Ballard | Mike Boddicker | Jeff Ballard | Rob Murphy | 272 | 275 | -3 |
| 1990-06-23 | vs BAL | 67 | W 4-3 | 38-29 | 2 | 33,767 | Roger Clemens | Dave Johnson | Jeff Gray | Gregg Olson | | 276 | 278 | -2 |
| 1990-06-24 | vs BAL | 68 | W 2-0 | 39-29 | 2 | 34,125 | Greg Harris | Bob Milacki | Greg Harris | Bob Milacki | Jeff Gray | 278 | 278 | 0 |
| 1990-06-25 | vs TOR | 69 | W 10-8 | 40-29 | 1 | 32,591 | Dana Kiecker | Dave Stieb | Dennis Lamp | Willie Blair | Jeff Reardon | 288 | 286 | 2 |
| 1990-06-26 | vs TOR | 70 | W 3-0 | 41-29 | 1 | 23,244 | Wes Gardner | David Wells | Wes Gardner | David Wells | Jeff Reardon | 291 | 286 | 5 |
| 1990-06-27 | vs TOR | 71 | W 9-5 | 42-29 | 1 | 32,961 | Mike Boddicker | Jimmy Key | Mike Boddicker | Jimmy Key | Jeff Gray | 300 | 291 | 9 |
| 1990-06-28 | vs TOR | 72 | W 4-3 | 43-29 | 1 | 34,547 | Roger Clemens | Todd Stottlemyre | Roger Clemens | Todd Stottlemyre | Jeff Reardon | 304 | 294 | 10 |
| 1990-06-29 | vs TEX | 73 | L 3-4 | 43-30 | 1 | 33,083 | Greg Harris | Charlie Hough | John Barfield | Jeff Gray | | 307 | 298 | 9 |
| 1990-06-30 | vs TEX | 74 | L 5-6 | 43-31 | 1 | 33,184 | Dana Kiecker | Mike Jeffcoat | Mike Jeffcoat | Jeff Reardon | Kenny Rogers | 312 | 304 | 8 |
| 1990-07-01 | vs TEX | 75 | W 15-4 | 44-31 | 1 | 33,825 | Wes Gardner | Kevin Brown | Tom Bolton | Kevin Brown | | 327 | 308 | 19 |
| 1990-07-02 | vs TEX | 76 | W 3-2 | 45-31 | 1 | 35,096 | Mike Boddicker | Nolan Ryan | Mike Boddicker | Kenny Rogers | | 330 | 310 | 20 |
| 1990-07-03 | @ MIN | 77 | L 3-7 | 45-32 | 1 | 20,521 | Roger Clemens | Kevin Tapani | Kevin Tapani | Roger Clemens | Rick Aguilera | 333 | 317 | 16 |
| 1990-07-04 | @ MIN | 78 | W 4-3 | 46-32 | 1 | 23,604 | Greg Harris | David West | Dennis Lamp | Rick Aguilera | Jeff Reardon | 337 | 320 | 17 |
| 1990-07-05 | @ MIN | 79 | L 4-7 | 46-33 | 1 | 18,473 | Dana Kiecker | Scott Erickson | Tim Drummond | Rob Murphy | Rick Aguilera | 341 | 327 | 14 |
| 1990-07-06 | @ TEX | 80 | L 0-4 | 46-34 | 1 | 32,540 | Wes Gardner | Kevin Brown | Kevin Brown | Wes Gardner | | 341 | 331 | 10 |
| 1990-07-07 | @ TEX | 81 | L 4-7 | 46-35 | 1 | 41,773 | Mike Boddicker | Nolan Ryan | Nolan Ryan | Mike Boddicker | Kenny Rogers | 345 | 338 | 7 |
| 1990-07-08 | @ TEX | 82 | L 3-4 | 46-36 | 1 | 26,819 | Roger Clemens | Bobby Witt | Kenny Rogers | Jeff Gray | | 348 | 342 | 6 |
| 1990-07-13 | vs KCA | 83 | L 3-5 | 46-37 | 1 | 34,701 | Mike Boddicker | Tom Gordon | Tom Gordon | Mike Boddicker | Jeff Montgomery | 351 | 347 | 4 |
| 1990-07-14 | vs KCA | 84 | L 1-2 | 47-38 | 1 | 34,287 | Roger Clemens | Luis Aquino | Luis Aquino | Rob Murphy | Jeff Montgomery | 352 | 349 | 3 |
| 1990-07-14 | vs KCA | 85 | W 8-7 | 47-38 | 1 | 27,163 | Greg Harris | Kevin Appier | Tom Bolton | Jay Baller | Jeff Reardon | 360 | 356 | 4 |
| 1990-07-15 | vs KCA | 86 | L 4-13 | 47-39 | 1 | 34,054 | Dana Kiecker | Bret Saberhagen | Steve Crawford | Dana Kiecker | | 364 | 369 | -5 |
| 1990-07-16 | vs MIN | 87 | L 2-3 | 47-40 | 2 | 33,445 | Wes Gardner | Mark Guthrie | Juan Berenguer | Jeff Gray | Rick Aguilera | 366 | 372 | -6 |
| 1990-07-17 | vs MIN | 88 | W 1-0 | 48-40 | 1 | 34,113 | Tom Bolton | Scott Erickson | Tom Bolton | Scott Erickson | Jeff Reardon | 367 | 372 | -5 |
| 1990-07-18 | vs MIN | 89 | W 5-4 | 49-40 | 1 | 34,838 | Mike Boddicker | David West | Dennis Lamp | Juan Berenguer | Jeff Reardon | 372 | 376 | -4 |
| 1990-07-19 | @ DET | 90 | L 0-1 | 49-41 | 1 | 12,678 | Greg Harris | Jeff Robinson | Jeff Robinson | Greg Harris | Jerry Gleaton | 372 | 377 | -5 |
| 1990-07-20 | @ KCA | 91 | L 0-5 | 50-42 | 1 | 0 | Roger Clemens | Kevin Appier | Kevin Appier | Roger Clemens | | 372 | 382 | -10 |
| 1990-07-20 | @ KCA | 92 | W 3-1 | 50-42 | 1 | 36,750 | Dana Kiecker | Luis Aquino | Dana Kiecker | Luis Aquino | Jeff Reardon | 375 | 383 | -8 |
| 1990-07-21 | @ KCA | 93 | L 2-4 | 50-43 | 2 | 35,600 | Wes Gardner | Pete Filson | Steve Farr | Jeff Reardon | Jeff Montgomery | 377 | 387 | -10 |
| 1990-07-22 | @ KCA | 94 | L 1-2 | 50-44 | 2 | 33,255 | Tom Bolton | Storm Davis | Storm Davis | Tom Bolton | Jeff Montgomery | 378 | 389 | -11 |
| 1990-07-23 | @ MIL | 95 | L 0-13 | 50-45 | 2 | 20,980 | Mike Boddicker | Mark Knudson | Mark Knudson | Mike Boddicker | | 378 | 402 | -24 |
| 1990-07-24 | @ MIL | 96 | L 5-6 | 50-46 | 2 | 24,718 | Greg Harris | Bill Krueger | Dan Plesac | Jerry Reed | | 383 | 408 | -25 |
| 1990-07-25 | @ MIL | 97 | W 2-0 | 51-46 | 1 | 35,948 | Roger Clemens | Chris Bosio | Roger Clemens | Chris Bosio | | 385 | 408 | -23 |
| 1990-07-26 | @ DET | 98 | L 4-10 | 51-47 | 2 | 20,564 | Wes Gardner | Dan Petry | Dan Petry | Wes Gardner | | 389 | 418 | -29 |
| 1990-07-27 | @ DET | 99 | W 1-0 | 52-47 | 2 | 27,556 | Tom Bolton | Jack Morris | Tom Bolton | Jack Morris | Rob Murphy | 390 | 418 | -28 |
| 1990-07-28 | @ DET | 100 | L 9-17 | 52-48 | 2 | 39,727 | Mike Boddicker | Frank Tanana | Paul Gibson | Dennis Lamp | | 399 | 435 | -36 |
| 1990-07-29 | @ DET | 101 | W 13-3 | 53-48 | 2 | 28,631 | Greg Harris | Jeff Robinson | Greg Harris | Jeff Robinson | | 412 | 438 | -26 |
| 1990-07-30 | vs CHA | 102 | W 3-0 | 54-48 | 2 | 35,599 | Roger Clemens | Adam Peterson | Roger Clemens | Adam Peterson | | 415 | 438 | -23 |
| 1990-07-31 | vs CHA | 103 | W 7-2 | 55-48 | 1 | 33,033 | Dana Kiecker | Eric King | Dana Kiecker | Eric King | | 422 | 440 | -18 |
| 1990-08-01 | vs CHA | 104 | W 9-5 | 56-48 | 1 | 35,522 | Tom Bolton | Jack McDowell | Tom Bolton | Jack McDowell | | 431 | 445 | -14 |
| 1990-08-03 | vs DET | 105 | W 14-5 | 57-48 | 1 | 34,713 | Greg Harris | Jeff Robinson | Greg Harris | Jeff Robinson | | 445 | 450 | -5 |
| 1990-08-04 | vs DET | 106 | W 3-1 | 58-48 | 1 | 34,857 | Roger Clemens | Steve Searcy | Roger Clemens | Steve Searcy | Rob Murphy | 448 | 451 | -3 |
| 1990-08-05 | vs DET | 107 | L 2-7 | 58-49 | 1 | 34,581 | Mike Boddicker | Dan Petry | Dan Petry | Mike Boddicker | Jerry Gleaton | 450 | 458 | -8 |
| 1990-08-07 | @ CAL | 108 | W 6-3 | 59-49 | 1 | 29,262 | Tom Bolton | Mark Langston | Tom Bolton | Mark Langston | Rob Murphy | 456 | 461 | -5 |
| 1990-08-08 | @ CAL | 109 | L 6-8 | 59-50 | 1 | 29,362 | Greg Harris | Kirk McCaskill | Willie Fraser | Dennis Lamp | | 462 | 469 | -7 |
| 1990-08-09 | @ CAL | 110 | W 14-3 | 60-50 | 1 | 32,802 | Roger Clemens | Jim Abbott | Roger Clemens | Jim Abbott | | 476 | 472 | 4 |
| 1990-08-10 | @ SEA | 111 | L 1-4 | 60-51 | 1 | 20,506 | Dana Kiecker | Randy Johnson | Randy Johnson | Dana Kiecker | Mike Schooler | 477 | 476 | 1 |
| 1990-08-11 | @ SEA | 112 | W 4-2 | 61-51 | 1 | 30,113 | Mike Boddicker | Bill Swift | Daryl Irvine | Mike Schooler | | 481 | 478 | 3 |
| 1990-08-12 | @ SEA | 113 | W 7-2 | 62-51 | 1 | 25,553 | Tom Bolton | Erik Hanson | Tom Bolton | Michael Jackson | | 488 | 480 | 8 |
| 1990-08-13 | @ OAK | 114 | L 0-4 | 62-52 | 1 | 34,758 | Greg Harris | Scott Sanderson | Scott Sanderson | Greg Harris | | 488 | 484 | 4 |
| 1990-08-14 | @ OAK | 115 | W 2-0 | 63-52 | 1 | 38,009 | Roger Clemens | Mike Moore | Roger Clemens | Mike Moore | | 490 | 484 | 6 |
| 1990-08-15 | @ OAK | 116 | L 2-6 | 63-53 | 1 | 41,704 | Dana Kiecker | Dave Stewart | Dave Stewart | Daryl Irvine | | 492 | 490 | 2 |
| 1990-08-17 | vs CAL | 117 | L 0-1 | 63-54 | 1 | 35,107 | Mike Boddicker | Chuck Finley | Chuck Finley | Mike Boddicker | | 492 | 491 | 1 |
| 1990-08-18 | vs CAL | 118 | L 3-4 | 63-55 | 1 | 34,131 | Tom Bolton | Kirk McCaskill | Kirk McCaskill | Tom Bolton | Bryan Harvey | 495 | 495 | 0 |
| 1990-08-19 | vs CAL | 119 | W 4-1 | 64-55 | 1 | 33,365 | Roger Clemens | Jim Abbott | Roger Clemens | Jim Abbott | Jeff Gray | 499 | 496 | 3 |
| 1990-08-20 | vs BAL | 120 | W 2-1 | 65-55 | 1 | 35,060 | Greg Harris | Pete Harnisch | Greg Harris | Pete Harnisch | Jeff Gray | 501 | 497 | 4 |
| 1990-08-21 | vs BAL | 121 | L 5-9 | 65-56 | 1 | 35,022 | Dana Kiecker | John Mitchell | John Mitchell | Dana Kiecker | Gregg Olson | 506 | 506 | 0 |
| 1990-08-22 | vs BAL | 122 | W 13-2 | 66-56 | 1 | 35,189 | Mike Boddicker | Ben McDonald | Mike Boddicker | Ben McDonald | | 519 | 508 | 11 |
| 1990-08-23 | @ TOR | 123 | L 3-4 | 66-57 | 1 | 49,918 | Tom Bolton | Dave Stieb | Tom Henke | Joe Hesketh | | 522 | 512 | 10 |
| 1990-08-24 | @ TOR | 124 | W 2-0 | 67-57 | 1 | 49,914 | Dana Kiecker | Jimmy Key | Dana Kiecker | Duane Ward | Jeff Gray | 524 | 512 | 12 |
| 1990-08-25 | @ TOR | 125 | W 1-0 | 68-57 | 1 | 49,890 | Roger Clemens | David Wells | Roger Clemens | David Wells | | 525 | 512 | 13 |
| 1990-08-26 | @ TOR | 126 | W 1-0 | 69-57 | 1 | 49,897 | Greg Harris | Todd Stottlemyre | Greg Harris | Todd Stottlemyre | Jeff Gray | 526 | 512 | 14 |
| 1990-08-27 | @ CLE | 127 | W 12-4 | 70-57 | 1 | 10,411 | Mike Boddicker | Tom Candiotti | Mike Boddicker | Tom Candiotti | | 538 | 516 | 22 |
| 1990-08-28 | @ CLE | 128 | W 6-5 | 71-57 | 1 | 10,799 | Tom Bolton | Charles Nagy | Wes Gardner | Doug Jones | Jeff Gray | 544 | 521 | 23 |
| 1990-08-29 | @ CLE | 129 | W 7-1 | 72-57 | 1 | 8,862 | Dana Kiecker | Mike Walker | Dana Kiecker | Mike Walker | | 551 | 522 | 29 |
| 1990-08-30 | @ CLE | 130 | W 9-2 | 73-57 | 1 | 9,651 | Roger Clemens | Sergio Valdez | Roger Clemens | Doug Jones | | 560 | 524 | 36 |
| 1990-08-31 | vs NYA | 131 | W 7-3 | 74-57 | 1 | 34,464 | Greg Harris | Chuck Cary | Greg Harris | Chuck Cary | Jeff Gray | 567 | 527 | 40 |
| 1990-09-01 | vs NYA | 132 | W 15-1 | 75-57 | 1 | 34,482 | Mike Boddicker | Andy Hawkins | Mike Boddicker | Andy Hawkins | | 582 | 528 | 54 |
| 1990-09-02 | vs NYA | 133 | W 7-1 | 76-57 | 1 | 35,458 | Tom Bolton | Mike Witt | Tom Bolton | Mike Witt | | 589 | 529 | 60 |
| 1990-09-03 | vs OAK | 134 | L 5-9 | 76-58 | 1 | 34,692 | Dana Kiecker | Scott Sanderson | Scott Sanderson | Dana Kiecker | | 594 | 538 | 56 |
| 1990-09-04 | vs OAK | 135 | L 2-6 | 76-59 | 1 | 35,408 | Roger Clemens | Dave Stewart | Dave Stewart | Roger Clemens | | 596 | 544 | 52 |
| 1990-09-05 | vs OAK | 136 | L 0-10 | 76-60 | 1 | 33,156 | Greg Harris | Bob Welch | Bob Welch | Greg Harris | | 596 | 554 | 42 |
| 1990-09-07 | vs SEA | 137 | W 5-4 | 77-60 | 1 | 32,868 | Mike Boddicker | Russ Swan | Jeff Gray | Michael Jackson | | 601 | 558 | 43 |
| 1990-09-08 | vs SEA | 138 | W 10-2 | 78-60 | 1 | 32,680 | Tom Bolton | Rich DeLucia | Tom Bolton | Scott Medvin | | 611 | 560 | 51 |
| 1990-09-09 | vs SEA | 139 | L 1-3 | 78-61 | 1 | 33,923 | Joe Hesketh | Matt Young | Matt Young | Joe Hesketh | Bill Swift | 612 | 563 | 49 |
| 1990-09-10 | vs MIL | 140 | W 5-4 | 79-62 | 1 | 0 | Greg Harris | Mark Knudson | Greg Harris | Mark Knudson | Jeff Gray | 617 | 567 | 50 |
| 1990-09-10 | vs MIL | 141 | L 1-6 | 79-62 | 1 | 28,757 | Dana Kiecker | Tom Edens | Tom Edens | Dana Kiecker | Chuck Crim | 618 | 573 | 45 |
| 1990-09-11 | vs MIL | 142 | L 2-4 | 79-63 | 1 | 27,778 | Dennis Lamp | Ron Robinson | Ron Robinson | Wes Gardner | Dan Plesac | 620 | 577 | 43 |
| 1990-09-12 | vs MIL | 143 | W 6-1 | 80-63 | 1 | 29,098 | Mike Boddicker | Teddy Higuera | Mike Boddicker | Teddy Higuera | | 626 | 578 | 48 |
| 1990-09-13 | @ CHA | 144 | L 6-9 | 80-64 | 1 | 27,648 | Tom Bolton | Alex Fernandez | Alex Fernandez | Tom Bolton | Ken Patterson | 632 | 587 | 45 |
| 1990-09-14 | @ CHA | 145 | L 0-4 | 80-65 | 1 | 34,349 | Joe Hesketh | Jack McDowell | Jack McDowell | Joe Hesketh | | 632 | 591 | 41 |
| 1990-09-15 | @ CHA | 146 | L 4-7 | 80-66 | 1 | 41,197 | Greg Harris | Greg Hibbard | Greg Hibbard | Greg Harris | Bobby Thigpen | 636 | 598 | 38 |
| 1990-09-16 | @ CHA | 147 | L 2-4 | 80-67 | 1 | 37,561 | Dana Kiecker | Eric King | Eric King | Dana Kiecker | Bobby Thigpen | 638 | 602 | 36 |
| 1990-09-17 | @ BAL | 148 | W 7-3 | 81-67 | 1 | 22,826 | Mike Boddicker | Ben McDonald | Mike Boddicker | Ben McDonald | | 645 | 605 | 40 |
| 1990-09-18 | @ BAL | 149 | L 1-4 | 81-68 | 1 | 23,308 | Tom Bolton | Jose Mesa | Jose Mesa | Tom Bolton | Gregg Olson | 646 | 609 | 37 |
| 1990-09-19 | @ BAL | 150 | L 4-8 | 81-69 | 2 | 25,598 | Greg Harris | Anthony Telford | Anthony Telford | Greg Harris | Curt Schilling | 650 | 617 | 33 |
| 1990-09-21 | @ NYA | 151 | W 3-0 | 82-69 | 1 | 27,573 | Dana Kiecker | Chuck Cary | Dana Kiecker | Chuck Cary | Larry Andersen | 653 | 617 | 36 |
| 1990-09-22 | @ NYA | 152 | L 2-5 | 82-70 | 1 | 37,795 | Mike Boddicker | Steve Adkins | Eric Plunk | Jeff Gray | Dave Righetti | 655 | 622 | 33 |
| 1990-09-23 | @ NYA | 153 | L 4-5 | 82-71 | 2 | 40,431 | Tom Bolton | Mike Witt | Mike Witt | Tom Bolton | Dave Righetti | 659 | 627 | 32 |
| 1990-09-25 | vs CLE | 154 | L 2-5 | 82-72 | 2 | 28,670 | Greg Harris | Greg Swindell | Greg Swindell | Greg Harris | Doug Jones | 661 | 632 | 29 |
| 1990-09-26 | vs CLE | 155 | W 7-2 | 83-72 | 2 | 28,824 | Dana Kiecker | Tom Candiotti | Dana Kiecker | Tom Candiotti | | 668 | 634 | 34 |
| 1990-09-27 | @ DET | 156 | W 3-2 | 84-72 | 1 | 13,247 | Tom Bolton | Steve Searcy | Tom Bolton | Steve Searcy | Jeff Reardon | 671 | 636 | 35 |
| 1990-09-28 | vs TOR | 157 | W 7-6 | 85-72 | 1 | 35,735 | Mike Boddicker | Dave Stieb | Jeff Reardon | Tom Henke | | 678 | 642 | 36 |
| 1990-09-29 | vs TOR | 158 | W 7-5 | 86-72 | 1 | 35,444 | Roger Clemens | Todd Stottlemyre | Roger Clemens | Todd Stottlemyre | Jeff Reardon | 685 | 647 | 38 |
| 1990-09-30 | vs TOR | 159 | L 5-10 | 86-73 | 1 | 34,400 | Greg Harris | Jimmy Key | Jimmy Key | Joe Hesketh | | 690 | 657 | 33 |
| 1990-10-01 | vs CHA | 160 | W 4-3 | 87-73 | 1 | 31,118 | Dana Kiecker | Greg Hibbard | Jeff Reardon | Barry Jones | | 694 | 660 | 34 |
| 1990-10-02 | vs CHA | 161 | L 2-3 | 87-74 | 1 | 33,917 | Tom Bolton | Melido Perez | Donn Pall | Dennis Lamp | Wayne Edwards | 696 | 663 | 33 |
| 1990-10-03 | vs CHA | 162 | W 3-1 | 88-74 | 1 | 33,637 | Mike Boddicker | Alex Fernandez | Mike Boddicker | Alex Fernandez | Jeff Reardon | 699 | 664 | 35 |