| 1990-04-10 | @ CHN | 1 | L 1-2 | 0-1 | 6 | 7,791 | Bruce Ruffin | Mike Bielecki | Les Lancaster | Jeff Parrett | Mitch Williams | 1 | 2 | -1 |
| 1990-04-12 | @ CHN | 2 | W 5-4 | 1-2 | 6 | 0 | Terry Mulholland | Steve Wilson | Terry Mulholland | Steve Wilson | Roger McDowell | 6 | 6 | 0 |
| 1990-04-12 | @ CHN | 3 | L 3-6 | 1-2 | 6 | 7,717 | Pat Combs | Jose Nunez | Jose Nunez | Pat Combs | Mitch Williams | 9 | 12 | -3 |
| 1990-04-13 | vs SLN | 4 | L 0-11 | 1-3 | 6 | 32,173 | Ken Howell | John Tudor | John Tudor | Ken Howell | Bob Tewksbury | 9 | 23 | -14 |
| 1990-04-14 | vs SLN | 5 | W 6-2 | 2-3 | 5 | 15,613 | Bruce Ruffin | Joe Magrane | Bruce Ruffin | Joe Magrane | Jeff Parrett | 15 | 25 | -10 |
| 1990-04-15 | vs SLN | 6 | W 4-0 | 3-3 | 3 | 14,435 | Dennis Cook | Bryn Smith | Dennis Cook | Bryn Smith | Roger McDowell | 19 | 25 | -6 |
| 1990-04-16 | @ MON | 7 | L 4-5 | 3-4 | 5 | 11,063 | Terry Mulholland | Oil Can Boyd | Joe Hesketh | Jeff Parrett | Steve Frey | 23 | 30 | -7 |
| 1990-04-17 | @ MON | 8 | L 1-2 | 3-5 | 6 | 8,406 | Pat Combs | Mark Gardner | Drew Hall | Todd Frohwirth | Steve Frey | 24 | 32 | -8 |
| 1990-04-18 | @ MON | 9 | W 4-3 | 4-5 | 4 | 10,096 | Ken Howell | Kevin Gross | Ken Howell | Kevin Gross | Roger McDowell | 28 | 35 | -7 |
| 1990-04-19 | vs MON | 10 | L 0-5 | 4-6 | 6 | 8,417 | Bruce Ruffin | Dennis Martinez | Dennis Martinez | Bruce Ruffin | | 28 | 40 | -12 |
| 1990-04-20 | @ SLN | 11 | W 3-0 | 5-6 | 4 | 29,343 | Dennis Cook | Bryn Smith | Dennis Cook | Bryn Smith | | 31 | 40 | -9 |
| 1990-04-21 | @ SLN | 12 | W 7-6 | 6-6 | 4 | 39,798 | Terry Mulholland | Jose DeLeon | Roger McDowell | Scott Terry | | 38 | 46 | -8 |
| 1990-04-22 | @ SLN | 13 | W 5-3 | 7-6 | 3 | 36,819 | Pat Combs | Greg Mathews | Pat Combs | Ricky Horton | Roger McDowell | 43 | 49 | -6 |
| 1990-04-24 | vs CIN | 14 | W 6-3 | 8-6 | 3 | 19,161 | Ken Howell | Jose Rijo | Ken Howell | Jose Rijo | Roger McDowell | 49 | 52 | -3 |
| 1990-04-25 | vs CIN | 15 | L 7-12 | 8-7 | 4 | 18,497 | Bruce Ruffin | Rick Mahler | Rick Mahler | Bruce Ruffin | | 56 | 64 | -8 |
| 1990-04-27 | @ ATL | 16 | W 7-1 | 9-7 | 4 | 12,598 | Dennis Cook | Marty Clary | Dennis Cook | Mike Stanton | | 63 | 65 | -2 |
| 1990-04-28 | @ ATL | 17 | W 2-1 | 10-7 | 2 | 12,659 | Terry Mulholland | Tom Glavine | Jeff Parrett | Joe Boever | Roger McDowell | 65 | 66 | -1 |
| 1990-04-29 | @ ATL | 18 | L 1-3 | 10-8 | 3 | 11,966 | Pat Combs | Pete Smith | Pete Smith | Pat Combs | | 66 | 69 | -3 |
| 1990-04-30 | @ CIN | 19 | L 2-6 | 10-9 | 3 | 17,294 | Ken Howell | Jose Rijo | Jose Rijo | Ken Howell | Rob Dibble | 68 | 75 | -7 |
| 1990-05-01 | @ CIN | 20 | W 4-2 | 11-9 | 3 | 16,926 | Bruce Ruffin | Rick Mahler | Bruce Ruffin | Tim Birtsas | Roger McDowell | 72 | 77 | -5 |
| 1990-05-02 | vs HOU | 21 | W 14-4 | 12-9 | 2 | 15,196 | Dennis Cook | Jim Clancy | Dennis Cook | Jim Clancy | | 86 | 81 | 5 |
| 1990-05-03 | vs HOU | 22 | L 3-10 | 12-10 | 2 | 13,653 | Terry Mulholland | Bill Gullickson | Bill Gullickson | Terry Mulholland | Dave Smith | 89 | 91 | -2 |
| 1990-05-04 | vs LAN | 23 | W 8-3 | 13-10 | 2 | 8,926 | Pat Combs | Ramon Martinez | Don Carman | Ramon Martinez | | 97 | 94 | 3 |
| 1990-05-05 | vs LAN | 24 | L 0-3 | 13-11 | 2 | 25,290 | Ken Howell | Mike Morgan | Mike Morgan | Ken Howell | | 97 | 97 | 0 |
| 1990-05-06 | vs LAN | 25 | W 9-5 | 14-11 | 2 | 38,167 | Bruce Ruffin | John Wetteland | Don Carman | Mike Munoz | | 106 | 102 | 4 |
| 1990-05-08 | @ HOU | 26 | L 2-3 | 14-12 | 3 | 12,909 | Dennis Cook | Bill Gullickson | Dave Smith | Dickie Noles | | 108 | 105 | 3 |
| 1990-05-09 | @ HOU | 27 | W 10-1 | 15-12 | 3 | 11,257 | Pat Combs | Mike Scott | Pat Combs | Mike Scott | | 118 | 106 | 12 |
| 1990-05-11 | vs SFN | 28 | W 10-6 | 16-12 | 2 | 26,750 | Ken Howell | John Burkett | Ken Howell | John Burkett | | 128 | 112 | 16 |
| 1990-05-12 | vs SFN | 29 | L 2-6 | 16-13 | 2 | 24,272 | Bruce Ruffin | Scott Garrelts | Scott Garrelts | Bruce Ruffin | Jeff Brantley | 130 | 118 | 12 |
| 1990-05-13 | vs SFN | 30 | W 4-1 | 17-13 | 2 | 19,631 | Dennis Cook | Rick Reuschel | Dennis Cook | Rick Reuschel | | 134 | 119 | 15 |
| 1990-05-14 | @ SDN | 31 | L 1-5 | 17-14 | 2 | 16,389 | Pat Combs | Andy Benes | Andy Benes | Pat Combs | | 135 | 124 | 11 |
| 1990-05-15 | @ SDN | 32 | W 2-1 | 18-14 | 2 | 22,596 | Terry Mulholland | Dennis Rasmussen | Terry Mulholland | Dennis Rasmussen | Roger McDowell | 137 | 125 | 12 |
| 1990-05-16 | @ SDN | 33 | W 6-5 | 19-14 | 2 | 17,710 | Ken Howell | Ed Whitson | Ken Howell | Ed Whitson | Roger McDowell | 143 | 130 | 13 |
| 1990-05-18 | @ LAN | 34 | L 2-4 | 19-15 | 2 | 34,274 | Bruce Ruffin | Tim Belcher | Tim Belcher | Bruce Ruffin | Jay Howell | 145 | 134 | 11 |
| 1990-05-19 | @ LAN | 35 | W 15-12 | 20-15 | 2 | 44,703 | Dennis Cook | Fernando Valenzuela | Roger McDowell | Jay Howell | | 160 | 146 | 14 |
| 1990-05-20 | @ LAN | 36 | L 3-6 | 20-16 | 2 | 45,770 | Pat Combs | Ramon Martinez | Ramon Martinez | Pat Combs | Mike Hartley | 163 | 152 | 11 |
| 1990-05-21 | @ SFN | 37 | W 5-2 | 21-16 | 2 | 11,263 | Terry Mulholland | Scott Garrelts | Terry Mulholland | Scott Garrelts | Roger McDowell | 168 | 154 | 14 |
| 1990-05-22 | @ SFN | 38 | W 4-2 | 22-16 | 2 | 8,799 | Ken Howell | Rick Reuschel | Ken Howell | Rick Reuschel | Roger McDowell | 172 | 156 | 16 |
| 1990-05-24 | vs ATL | 39 | W 8-4 | 23-16 | 2 | 21,160 | Bruce Ruffin | Marty Clary | Bruce Ruffin | Marty Clary | Marvin Freeman | 180 | 160 | 20 |
| 1990-05-25 | vs ATL | 40 | W 5-4 | 24-16 | 1 | 22,162 | Dennis Cook | Tom Glavine | Jeff Parrett | Joe Hesketh | Roger McDowell | 185 | 164 | 21 |
| 1990-05-26 | vs ATL | 41 | L 3-12 | 24-17 | 2 | 56,789 | Pat Combs | Pete Smith | Pete Smith | Pat Combs | | 188 | 176 | 12 |
| 1990-05-27 | vs ATL | 42 | L 1-6 | 24-18 | 2 | 27,139 | Terry Mulholland | John Smoltz | John Smoltz | Terry Mulholland | | 189 | 182 | 7 |
| 1990-05-28 | vs SDN | 43 | L 5-9 | 24-19 | 2 | 18,390 | Ken Howell | Bruce Hurst | Mark Grant | Jeff Parrett | | 194 | 191 | 3 |
| 1990-05-30 | vs SDN | 44 | L 3-8 | 24-20 | 2 | 21,375 | Bruce Ruffin | Andy Benes | Andy Benes | Bruce Ruffin | Greg Harris | 197 | 199 | -2 |
| 1990-06-01 | vs NYN | 45 | L 0-4 | 24-21 | 3 | 34,457 | Dennis Cook | Frank Viola | Frank Viola | Dennis Cook | | 197 | 203 | -6 |
| 1990-06-02 | vs NYN | 46 | W 5-4 | 25-21 | 2 | 41,950 | Ken Howell | Dwight Gooden | Ken Howell | Dwight Gooden | Roger McDowell | 202 | 207 | -5 |
| 1990-06-03 | vs NYN | 47 | W 8-3 | 26-21 | 2 | 43,643 | Pat Combs | Sid Fernandez | Pat Combs | Sid Fernandez | | 210 | 210 | 0 |
| 1990-06-04 | @ SLN | 48 | L 2-3 | 26-22 | 3 | 29,937 | Terry Mulholland | John Tudor | Frank DiPino | Marvin Freeman | | 212 | 213 | -1 |
| 1990-06-05 | @ SLN | 49 | W 9-6 | 27-22 | 2 | 26,522 | Bruce Ruffin | Joe Magrane | Don Carman | Scott Terry | | 221 | 219 | 2 |
| 1990-06-06 | @ SLN | 50 | L 11-12 | 27-23 | 2 | 28,319 | Dennis Cook | Greg Mathews | Frank DiPino | Roger McDowell | | 232 | 231 | 1 |
| 1990-06-07 | @ CHN | 51 | W 3-1 | 28-23 | 2 | 29,271 | Ken Howell | Mike Bielecki | Ken Howell | Mike Bielecki | | 235 | 232 | 3 |
| 1990-06-08 | @ CHN | 52 | L 2-15 | 28-24 | 3 | 32,219 | Terry Mulholland | Jeff Pico | Jeff Pico | Terry Mulholland | | 237 | 247 | -10 |
| 1990-06-09 | @ CHN | 53 | L 3-4 | 28-25 | 3 | 33,266 | Marvin Freeman | Shawn Boskie | Les Lancaster | Jeff Parrett | | 240 | 251 | -11 |
| 1990-06-10 | @ CHN | 54 | L 3-7 | 28-26 | 3 | 32,187 | Bruce Ruffin | Steve Wilson | Steve Wilson | Bruce Ruffin | Les Lancaster | 243 | 258 | -15 |
| 1990-06-11 | vs MON | 55 | L 0-5 | 28-28 | 3 | 0 | Dennis Cook | Kevin Gross | Kevin Gross | Dennis Cook | | 243 | 263 | -20 |
| 1990-06-11 | vs MON | 56 | L 2-3 | 28-28 | 3 | 22,700 | Pat Combs | Chris Nabholz | Drew Hall | Jeff Parrett | Dave J. Schmidt | 245 | 266 | -21 |
| 1990-06-12 | vs MON | 57 | W 7-2 | 29-28 | 3 | 19,169 | Ken Howell | Zane Smith | Ken Howell | Zane Smith | | 252 | 268 | -16 |
| 1990-06-13 | vs MON | 58 | L 3-4 | 29-29 | 4 | 18,655 | Jose De Jesus | Dennis Martinez | Dave J. Schmidt | Roger McDowell | Drew Hall | 255 | 272 | -17 |
| 1990-06-15 | vs CHN | 59 | W 6-5 | 31-29 | 4 | 0 | Pat Combs | Steve Wilson | Darrel Akerfelds | Jose Nunez | | 261 | 277 | -16 |
| 1990-06-15 | vs CHN | 60 | W 7-0 | 31-29 | 4 | 26,098 | Bruce Ruffin | Mike Bielecki | Bruce Ruffin | Mike Bielecki | | 268 | 277 | -9 |
| 1990-06-16 | vs CHN | 61 | W 2-1 | 32-29 | 3 | 32,023 | Dennis Cook | Greg Maddux | Darrel Akerfelds | Greg Maddux | | 270 | 278 | -8 |
| 1990-06-17 | vs CHN | 62 | L 3-5 | 32-30 | 4 | 30,338 | Ken Howell | Jeff Pico | Jeff Pico | Jeff Parrett | Les Lancaster | 273 | 283 | -10 |
| 1990-06-19 | vs PIT | 63 | W 2-1 | 33-30 | 4 | 29,781 | Jose De Jesus | Bob Walk | Don Carman | Bill Landrum | | 275 | 284 | -9 |
| 1990-06-20 | vs PIT | 64 | W 7-2 | 34-30 | 4 | 40,256 | Bruce Ruffin | Bob Patterson | Bruce Ruffin | Bob Patterson | | 282 | 286 | -4 |
| 1990-06-22 | @ NYN | 65 | L 1-5 | 34-31 | 4 | 43,587 | Ken Howell | Frank Viola | Frank Viola | Ken Howell | | 283 | 291 | -8 |
| 1990-06-23 | @ NYN | 66 | L 0-3 | 34-32 | 4 | 45,661 | Pat Combs | Dwight Gooden | Dwight Gooden | Pat Combs | | 283 | 294 | -11 |
| 1990-06-24 | @ NYN | 67 | L 5-6 | 34-33 | 4 | 47,836 | Marvin Freeman | Bob Ojeda | Jeff Innis | Roger McDowell | | 288 | 300 | -12 |
| 1990-06-25 | @ PIT | 68 | L 0-5 | 34-34 | 4 | 29,369 | Jose De Jesus | Rick Reed | Rick Reed | Jose De Jesus | | 288 | 305 | -17 |
| 1990-06-26 | @ PIT | 69 | L 0-1 | 34-35 | 4 | 25,807 | Bruce Ruffin | Bob Patterson | Scott Ruskin | Bruce Ruffin | Stan Belinda | 288 | 306 | -18 |
| 1990-06-27 | @ PIT | 70 | L 3-5 | 34-36 | 4 | 40,207 | Ken Howell | Walt Terrell | Bob Kipper | Ken Howell | Bill Landrum | 291 | 311 | -20 |
| 1990-06-29 | vs HOU | 71 | W 2-0 | 35-36 | 4 | 26,339 | Pat Combs | Bill Gullickson | Pat Combs | Bill Gullickson | | 293 | 311 | -18 |
| 1990-06-30 | vs HOU | 72 | L 3-8 | 35-37 | 4 | 27,111 | Marvin Freeman | Mike Scott | Mike Scott | Marvin Freeman | Juan Agosto | 296 | 319 | -23 |
| 1990-07-01 | vs HOU | 73 | W 8-4 | 36-37 | 4 | 27,014 | Jose De Jesus | Danny Darwin | Roger McDowell | Larry Andersen | | 304 | 323 | -19 |
| 1990-07-02 | vs HOU | 74 | W 5-1 | 37-37 | 4 | 32,349 | Bruce Ruffin | Jim Deshaies | Bruce Ruffin | Jim Deshaies | Darrel Akerfelds | 309 | 324 | -15 |
| 1990-07-03 | vs ATL | 75 | W 5-1 | 38-37 | 4 | 55,147 | Jeff Parrett | Marty Clary | Jeff Parrett | Marty Clary | Dennis Cook | 314 | 325 | -11 |
| 1990-07-04 | vs ATL | 76 | L 1-4 | 38-38 | 4 | 18,286 | Pat Combs | Tom Glavine | Tom Glavine | Pat Combs | Joe Boever | 315 | 329 | -14 |
| 1990-07-05 | vs CIN | 77 | L 2-9 | 38-39 | 4 | 19,961 | Ken Howell | Jack Armstrong | Jack Armstrong | Ken Howell | | 317 | 338 | -21 |
| 1990-07-06 | vs CIN | 78 | L 1-4 | 38-40 | 4 | 28,501 | Jose De Jesus | Danny Jackson | Danny Jackson | Jose De Jesus | Randy Myers | 318 | 342 | -24 |
| 1990-07-07 | vs CIN | 79 | L 0-5 | 38-41 | 4 | 29,515 | Bruce Ruffin | Rick Mahler | Rick Mahler | Bruce Ruffin | | 318 | 347 | -29 |
| 1990-07-08 | vs CIN | 80 | W 4-3 | 39-41 | 4 | 31,602 | Jeff Parrett | Tom Browning | Darrel Akerfelds | Norm Charlton | | 322 | 350 | -28 |
| 1990-07-12 | @ HOU | 81 | L 4-7 | 39-42 | 4 | 16,983 | Bruce Ruffin | Bill Gullickson | Bill Gullickson | Bruce Ruffin | Dave Smith | 326 | 357 | -31 |
| 1990-07-13 | @ HOU | 82 | W 4-2 | 40-42 | 4 | 15,248 | Jose De Jesus | Mike Scott | Jose De Jesus | Mike Scott | Darrel Akerfelds | 330 | 359 | -29 |
| 1990-07-14 | @ HOU | 83 | W 12-8 | 41-42 | 4 | 28,308 | Pat Combs | Jim Deshaies | Pat Combs | Jim Deshaies | | 342 | 367 | -25 |
| 1990-07-15 | @ HOU | 84 | L 1-6 | 41-43 | 4 | 19,616 | Jeff Parrett | Danny Darwin | Danny Darwin | Jeff Parrett | | 343 | 373 | -30 |
| 1990-07-16 | @ ATL | 85 | W 7-2 | 42-43 | 4 | 8,211 | Terry Mulholland | Marty Clary | Terry Mulholland | Marty Clary | | 350 | 375 | -25 |
| 1990-07-17 | @ ATL | 86 | L 10-14 | 42-44 | 4 | 8,558 | Bruce Ruffin | Tom Glavine | Tom Glavine | Bruce Ruffin | Kent Mercker | 360 | 389 | -29 |
| 1990-07-18 | @ ATL | 87 | W 4-3 | 43-44 | 4 | 8,706 | Jose De Jesus | John Smoltz | Dennis Cook | John Smoltz | Darrel Akerfelds | 364 | 392 | -28 |
| 1990-07-19 | @ CIN | 88 | W 5-2 | 44-44 | 4 | 37,163 | Pat Combs | Jack Armstrong | Pat Combs | Jack Armstrong | Roger McDowell | 369 | 394 | -25 |
| 1990-07-20 | @ CIN | 89 | L 1-5 | 44-45 | 4 | 39,394 | Jeff Parrett | Norm Charlton | Norm Charlton | Jeff Parrett | Rob Dibble | 370 | 399 | -29 |
| 1990-07-21 | @ CIN | 90 | L 1-6 | 44-46 | 4 | 34,506 | Terry Mulholland | Jose Rijo | Jose Rijo | Terry Mulholland | Rick Mahler | 371 | 405 | -34 |
| 1990-07-22 | @ CIN | 91 | W 6-2 | 45-46 | 4 | 33,658 | Jose De Jesus | Scott Scudder | Jose De Jesus | Scott Scudder | | 377 | 407 | -30 |
| 1990-07-23 | vs NYN | 92 | W 7-4 | 46-46 | 4 | 39,260 | Bruce Ruffin | Frank Viola | Darrel Akerfelds | Frank Viola | Roger McDowell | 384 | 411 | -27 |
| 1990-07-24 | vs NYN | 93 | L 4-7 | 46-47 | 4 | 43,235 | Pat Combs | David Cone | Julio Machado | Roger McDowell | John Franco | 388 | 418 | -30 |
| 1990-07-25 | vs NYN | 94 | L 9-10 | 46-48 | 4 | 40,079 | Jeff Parrett | Sid Fernandez | Sid Fernandez | Jeff Parrett | John Franco | 397 | 428 | -31 |
| 1990-07-26 | @ PIT | 95 | W 12-4 | 47-48 | 4 | 24,088 | Terry Mulholland | Neal Heaton | Terry Mulholland | Neal Heaton | | 409 | 432 | -23 |
| 1990-07-27 | @ PIT | 96 | W 5-3 | 48-48 | 4 | 29,117 | Jose De Jesus | Rick Reed | Dennis Cook | Rick Reed | Joe Boever | 414 | 435 | -21 |
| 1990-07-28 | @ PIT | 97 | W 4-3 | 49-48 | 4 | 37,022 | Bruce Ruffin | John Smiley | Jeff Parrett | Bill Landrum | Joe Boever | 418 | 438 | -20 |
| 1990-07-29 | @ PIT | 98 | L 1-2 | 49-49 | 4 | 33,018 | Pat Combs | Doug Drabek | Doug Drabek | Pat Combs | | 419 | 440 | -21 |
| 1990-07-31 | vs SLN | 99 | L 2-4 | 49-50 | 4 | 25,463 | Ken Howell | John Tudor | John Tudor | Ken Howell | Lee Smith | 421 | 444 | -23 |
| 1990-08-01 | vs SLN | 100 | W 11-10 | 50-50 | 4 | 23,142 | Terry Mulholland | Ken Hill | Terry Mulholland | Ken Hill | Roger McDowell | 432 | 454 | -22 |
| 1990-08-02 | vs SLN | 101 | L 3-4 | 50-51 | 4 | 21,898 | Jose De Jesus | Bob Tewksbury | Bob Tewksbury | Jose De Jesus | Lee Smith | 435 | 458 | -23 |
| 1990-08-03 | vs PIT | 102 | L 0-11 | 50-52 | 4 | 36,057 | Bruce Ruffin | Doug Drabek | Doug Drabek | Bruce Ruffin | | 435 | 469 | -34 |
| 1990-08-04 | vs PIT | 103 | L 1-3 | 50-53 | 4 | 45,305 | Pat Combs | Neal Heaton | Bob Patterson | Roger McDowell | Ted Power | 436 | 472 | -36 |
| 1990-08-05 | vs PIT | 104 | W 8-6 | 51-53 | 4 | 40,142 | Ken Howell | Bob Walk | Don Carman | Scott Ruskin | Joe Boever | 444 | 478 | -34 |
| 1990-08-06 | vs PIT | 105 | L 1-10 | 51-55 | 4 | 0 | Terry Mulholland | Randy Tomlin | Randy Tomlin | Terry Mulholland | | 445 | 488 | -43 |
| 1990-08-06 | vs PIT | 106 | L 3-4 | 51-55 | 4 | 30,827 | Dennis Cook | Rick Reed | Bill Landrum | Roger McDowell | | 448 | 492 | -44 |
| 1990-08-07 | @ NYN | 107 | W 9-0 | 52-55 | 4 | 33,120 | Jose De Jesus | Frank Viola | Jose De Jesus | Frank Viola | | 457 | 492 | -35 |
| 1990-08-08 | @ NYN | 108 | L 4-8 | 52-56 | 5 | 41,204 | Don Carman | David Cone | David Cone | Don Carman | | 461 | 500 | -39 |
| 1990-08-09 | @ NYN | 109 | L 4-5 | 52-57 | 5 | 39,240 | Pat Combs | Dwight Gooden | Bob Ojeda | Darrel Akerfelds | John Franco | 465 | 505 | -40 |
| 1990-08-10 | @ MON | 110 | L 3-4 | 52-58 | 5 | 17,904 | Terry Mulholland | Oil Can Boyd | Oil Can Boyd | Terry Mulholland | Steve Frey | 468 | 509 | -41 |
| 1990-08-11 | @ MON | 111 | L 4-5 | 52-59 | 5 | 23,708 | Jason Grimsley | Mark Gardner | Bill Sampen | Don Carman | | 472 | 514 | -42 |
| 1990-08-12 | @ MON | 112 | L 3-6 | 52-60 | 6 | 29,186 | Jose De Jesus | Chris Nabholz | Chris Nabholz | Jose De Jesus | Tim Burke | 475 | 520 | -45 |
| 1990-08-14 | vs SFN | 113 | W 4-3 | 53-60 | 5 | 29,538 | Pat Combs | Mike LaCoss | Dennis Cook | Steve Bedrosian | | 479 | 523 | -44 |
| 1990-08-15 | vs SFN | 114 | W 6-0 | 54-60 | 5 | 32,156 | Terry Mulholland | Don Robinson | Terry Mulholland | Don Robinson | | 485 | 523 | -38 |
| 1990-08-16 | vs SFN | 115 | W 6-4 | 55-60 | 5 | 37,340 | Jason Grimsley | John Burkett | Roger McDowell | Mark Thurmond | | 491 | 527 | -36 |
| 1990-08-17 | @ SDN | 116 | W 2-1 | 56-60 | 5 | 18,488 | Jose De Jesus | Calvin Schiraldi | Jose De Jesus | Calvin Schiraldi | | 493 | 528 | -35 |
| 1990-08-18 | @ SDN | 117 | L 2-4 | 56-61 | 5 | 35,145 | Tommy Greene | Andy Benes | Andy Benes | Tommy Greene | Craig Lefferts | 495 | 532 | -37 |
| 1990-08-19 | @ SDN | 118 | W 3-2 | 57-61 | 5 | 22,627 | Pat Combs | Dennis Rasmussen | Joe Boever | Dennis Rasmussen | Roger McDowell | 498 | 534 | -36 |
| 1990-08-20 | @ LAN | 119 | L 1-2 | 57-62 | 5 | 28,112 | Terry Mulholland | Mike Morgan | Jim Gott | Terry Mulholland | | 499 | 536 | -37 |
| 1990-08-21 | @ LAN | 120 | W 12-11 | 58-62 | 5 | 39,682 | Jason Grimsley | Mike Hartley | Roger McDowell | Tim Crews | Don Carman | 511 | 547 | -36 |
| 1990-08-22 | @ LAN | 121 | L 2-3 | 58-63 | 5 | 27,934 | Jose De Jesus | Jim Neidlinger | Jim Gott | Joe Boever | | 513 | 550 | -37 |
| 1990-08-23 | @ SFN | 122 | L 3-6 | 58-64 | 5 | 13,918 | Tommy Greene | Kelly Downs | Francisco Oliveras | Dennis Cook | Steve Bedrosian | 516 | 556 | -40 |
| 1990-08-24 | @ SFN | 123 | L 2-13 | 58-65 | 5 | 15,961 | Pat Combs | Mike LaCoss | Mike LaCoss | Pat Combs | | 518 | 569 | -51 |
| 1990-08-25 | @ SFN | 124 | L 2-4 | 58-66 | 5 | 28,208 | Terry Mulholland | Don Robinson | Don Robinson | Terry Mulholland | Jeff Brantley | 520 | 573 | -53 |
| 1990-08-26 | @ SFN | 125 | W 5-1 | 59-66 | 5 | 30,208 | Jason Grimsley | John Burkett | Jason Grimsley | John Burkett | | 525 | 574 | -49 |
| 1990-08-28 | vs LAN | 126 | L 1-5 | 59-67 | 5 | 24,296 | Jose De Jesus | Jim Neidlinger | Jim Neidlinger | Jose De Jesus | | 526 | 579 | -53 |
| 1990-08-29 | vs LAN | 127 | L 2-12 | 59-68 | 5 | 18,545 | Tommy Greene | Fernando Valenzuela | Fernando Valenzuela | Tommy Greene | Tim Crews | 528 | 591 | -63 |
| 1990-08-30 | vs LAN | 128 | L 2-3 | 59-69 | 6 | 24,160 | Pat Combs | Ramon Martinez | Ramon Martinez | Joe Boever | Dave Walsh | 530 | 594 | -64 |
| 1990-08-31 | vs SDN | 129 | W 4-2 | 60-69 | 5 | 23,286 | Terry Mulholland | Dennis Rasmussen | Roger McDowell | Atlee Hammaker | | 534 | 596 | -62 |
| 1990-09-01 | vs SDN | 130 | W 3-2 | 62-69 | 5 | 0 | Jason Grimsley | Bruce Hurst | Joe Boever | Greg Harris | | 537 | 598 | -61 |
| 1990-09-01 | vs SDN | 131 | W 2-1 | 62-69 | 5 | 25,008 | Tommy Greene | Derek Lilliquist | Darrel Akerfelds | Rich Rodriguez | Roger McDowell | 539 | 599 | -60 |
| 1990-09-02 | vs SDN | 132 | L 1-9 | 62-70 | 5 | 33,498 | Jose De Jesus | Ed Whitson | Ed Whitson | Jose De Jesus | | 540 | 608 | -68 |
| 1990-09-03 | @ PIT | 133 | L 1-4 | 62-71 | 5 | 23,854 | Bruce Ruffin | Doug Drabek | Doug Drabek | Bruce Ruffin | | 541 | 612 | -71 |
| 1990-09-04 | @ PIT | 134 | L 7-11 | 62-72 | 5 | 16,858 | Pat Combs | Bob Walk | Bill Landrum | Darrel Akerfelds | Bob Patterson | 548 | 623 | -75 |
| 1990-09-05 | vs CHN | 135 | W 4-1 | 63-72 | 5 | 16,177 | Terry Mulholland | Mike Harkey | Terry Mulholland | Steve Wilson | Roger McDowell | 552 | 624 | -72 |
| 1990-09-06 | vs CHN | 136 | L 2-5 | 63-73 | 5 | 13,849 | Jason Grimsley | Jose Nunez | Jose Nunez | Jason Grimsley | Mitch Williams | 554 | 629 | -75 |
| 1990-09-07 | vs NYN | 137 | W 4-1 | 64-73 | 5 | 29,744 | Jose De Jesus | David Cone | Jose De Jesus | David Cone | | 558 | 630 | -72 |
| 1990-09-08 | vs NYN | 138 | L 2-12 | 64-74 | 5 | 37,489 | Bruce Ruffin | Dwight Gooden | Dwight Gooden | Bruce Ruffin | | 560 | 642 | -82 |
| 1990-09-09 | vs NYN | 139 | W 6-2 | 65-74 | 5 | 36,502 | Pat Combs | Sid Fernandez | Pat Combs | Sid Fernandez | Joe Boever | 566 | 644 | -78 |
| 1990-09-10 | vs PIT | 140 | L 2-3 | 65-75 | 5 | 18,970 | Terry Mulholland | Zane Smith | Stan Belinda | Joe Boever | | 568 | 647 | -79 |
| 1990-09-11 | vs PIT | 141 | L 1-5 | 65-76 | 5 | 20,289 | Jason Grimsley | Randy Tomlin | Randy Tomlin | Jason Grimsley | | 569 | 652 | -83 |
| 1990-09-12 | @ CHN | 142 | L 3-9 | 65-77 | 5 | 16,258 | Jose De Jesus | Greg Maddux | Greg Maddux | Jose De Jesus | | 572 | 661 | -89 |
| 1990-09-13 | @ CHN | 143 | L 5-6 | 65-78 | 5 | 15,495 | Bruce Ruffin | Rick Sutcliffe | Paul Assenmacher | Roger McDowell | Les Lancaster | 577 | 667 | -90 |
| 1990-09-14 | @ NYN | 144 | W 4-1 | 66-78 | 5 | 36,339 | Pat Combs | Sid Fernandez | Pat Combs | Sid Fernandez | | 581 | 668 | -87 |
| 1990-09-15 | @ NYN | 145 | L 2-4 | 66-79 | 5 | 45,202 | Terry Mulholland | Frank Viola | Frank Viola | Terry Mulholland | John Franco | 583 | 672 | -89 |
| 1990-09-16 | @ NYN | 146 | W 8-3 | 67-79 | 5 | 44,813 | Jose De Jesus | David Cone | Jose De Jesus | David Cone | | 591 | 675 | -84 |
| 1990-09-18 | @ SLN | 147 | W 6-3 | 68-79 | 5 | 15,588 | Jason Grimsley | Bob Tewksbury | Jason Grimsley | Bob Tewksbury | Joe Boever | 597 | 678 | -81 |
| 1990-09-19 | @ SLN | 148 | W 8-4 | 69-79 | 5 | 15,828 | Pat Combs | Joe Magrane | Pat Combs | Joe Magrane | | 605 | 682 | -77 |
| 1990-09-20 | @ SLN | 149 | L 4-5 | 69-80 | 5 | 14,744 | Terry Mulholland | Bryn Smith | Mike Perez | Roger McDowell | | 609 | 687 | -78 |
| 1990-09-21 | vs MON | 150 | W 5-4 | 70-80 | 5 | 23,274 | Jose De Jesus | Dennis Martinez | Chuck Malone | Bill Sampen | | 614 | 691 | -77 |
| 1990-09-22 | vs MON | 151 | W 3-2 | 71-80 | 5 | 17,215 | Tommy Greene | Scott Anderson | Tommy Greene | Scott Anderson | Roger McDowell | 617 | 693 | -76 |
| 1990-09-23 | vs MON | 152 | W 2-1 | 72-80 | 5 | 25,715 | Jason Grimsley | Oil Can Boyd | Don Carman | Howard Farmer | | 619 | 694 | -75 |
| 1990-09-24 | vs MON | 153 | W 3-0 | 73-80 | 5 | 11,527 | Pat Combs | Brian Barnes | Pat Combs | Brian Barnes | | 622 | 694 | -72 |
| 1990-09-25 | vs SLN | 154 | L 0-1 | 73-81 | 5 | 13,615 | Terry Mulholland | Joe Magrane | Joe Magrane | Terry Mulholland | Ken Dayley | 622 | 695 | -73 |
| 1990-09-26 | vs SLN | 155 | L 1-8 | 73-82 | 5 | 12,443 | Jose De Jesus | Bryn Smith | Bryn Smith | Jose De Jesus | | 623 | 703 | -80 |
| 1990-09-27 | vs SLN | 156 | W 4-3 | 74-82 | 4 | 9,119 | Tommy Greene | Jose DeLeon | Tommy Greene | Jose DeLeon | Joe Boever | 627 | 706 | -79 |
| 1990-09-28 | @ MON | 157 | W 5-4 | 75-82 | 4 | 8,230 | Jason Grimsley | Oil Can Boyd | Jason Grimsley | Oil Can Boyd | Roger McDowell | 632 | 710 | -78 |
| 1990-09-29 | @ MON | 158 | L 1-5 | 75-83 | 4 | 8,985 | Pat Combs | Brian Barnes | Brian Barnes | Pat Combs | | 633 | 715 | -82 |
| 1990-09-30 | @ MON | 159 | W 2-1 | 76-83 | 4 | 17,464 | Terry Mulholland | Chris Nabholz | Terry Mulholland | Chris Nabholz | | 635 | 716 | -81 |
| 1990-10-01 | vs CHN | 160 | W 7-6 | 77-83 | 4 | 9,041 | Jose De Jesus | Kevin Coffman | Jose De Jesus | Kevin Coffman | Roger McDowell | 642 | 722 | -80 |
| 1990-10-02 | vs CHN | 161 | L 1-3 | 77-84 | 4 | 9,940 | Tommy Greene | Mike Bielecki | Mike Bielecki | Tommy Greene | Mitch Williams | 643 | 725 | -82 |
| 1990-10-03 | vs CHN | 162 | L 3-4 | 77-85 | 5 | 11,889 | Jason Grimsley | Greg Maddux | Greg Maddux | Chuck McElroy | Paul Assenmacher | 646 | 729 | -83 |