| 1990-04-09 | vs MIN | 1 | W 8-3 | 1-0 | 2 | 48,219 | Dave Stewart | Allan Anderson | Dave Stewart | Allan Anderson | Rick Honeycutt | 8 | 3 | 5 |
| 1990-04-10 | vs MIN | 2 | W 5-3 | 2-0 | 2 | 19,757 | Bob Welch | Roy Smith | Bob Welch | Roy Smith | Dennis Eckersley | 13 | 6 | 7 |
| 1990-04-11 | vs MIN | 3 | L 0-3 | 2-1 | 2 | 27,775 | Mike Moore | Kevin Tapani | Kevin Tapani | Mike Moore | Rick Aguilera | 13 | 9 | 4 |
| 1990-04-13 | @ SEA | 4 | W 15-7 | 3-1 | 1 | 54,874 | Scott Sanderson | Scott Bankhead | Scott Sanderson | Scott Bankhead | | 28 | 16 | 12 |
| 1990-04-14 | @ SEA | 5 | W 5-2 | 4-1 | 1 | 25,961 | Dave Stewart | Matt Young | Dave Stewart | Matt Young | Dennis Eckersley | 33 | 18 | 15 |
| 1990-04-15 | @ SEA | 6 | W 3-0 | 5-1 | 1 | 17,139 | Bob Welch | Brian Holman | Bob Welch | Brian Holman | Dennis Eckersley | 36 | 18 | 18 |
| 1990-04-17 | @ CAL | 7 | W 7-5 | 6-1 | 1 | 34,370 | Mike Moore | Mark Langston | Mike Norris | Mark Eichhorn | Dennis Eckersley | 43 | 23 | 20 |
| 1990-04-18 | @ CAL | 8 | W 3-1 | 7-1 | 1 | 33,579 | Scott Sanderson | Kirk McCaskill | Scott Sanderson | Mike Witt | Gene Nelson | 46 | 24 | 22 |
| 1990-04-19 | vs SEA | 9 | W 5-2 | 8-1 | 1 | 23,979 | Dave Stewart | Gary Eave | Dave Stewart | Gary Eave | | 51 | 26 | 25 |
| 1990-04-20 | vs SEA | 10 | L 1-6 | 8-2 | 1 | 44,911 | Bob Welch | Brian Holman | Brian Holman | Bob Welch | | 52 | 32 | 20 |
| 1990-04-21 | vs SEA | 11 | W 7-6 | 9-2 | 1 | 33,277 | Mike Moore | Randy Johnson | Dennis Eckersley | Jerry Reed | | 59 | 38 | 21 |
| 1990-04-22 | vs SEA | 12 | L 2-5 | 9-3 | 1 | 40,901 | Scott Sanderson | Erik Hanson | Erik Hanson | Scott Sanderson | Michael Jackson | 61 | 43 | 18 |
| 1990-04-24 | @ BAL | 13 | W 7-1 | 10-3 | 1 | 25,431 | Dave Stewart | Dave Johnson | Dave Stewart | Dave Johnson | | 68 | 44 | 24 |
| 1990-04-25 | @ BAL | 14 | W 4-3 | 11-3 | 1 | 25,341 | Bob Welch | Bob Milacki | Gene Nelson | Kevin Hickey | Dennis Eckersley | 72 | 47 | 25 |
| 1990-04-26 | @ BAL | 15 | W 6-4 | 12-3 | 1 | 27,195 | Mike Moore | Jay Tibbs | Mike Moore | Jay Tibbs | Dennis Eckersley | 78 | 51 | 27 |
| 1990-04-27 | @ BOS | 16 | L 6-7 | 12-4 | 1 | 32,912 | Scott Sanderson | Dana Kiecker | Jeff Reardon | Gene Nelson | | 84 | 58 | 26 |
| 1990-04-28 | @ BOS | 17 | L 3-12 | 12-5 | 1 | 33,989 | Curt Young | Greg Harris | Greg Harris | Curt Young | | 87 | 70 | 17 |
| 1990-04-29 | @ BOS | 18 | W 1-0 | 13-5 | 1 | 33,237 | Dave Stewart | Roger Clemens | Dave Stewart | Roger Clemens | Dennis Eckersley | 88 | 70 | 18 |
| 1990-04-30 | @ NYA | 19 | W 6-0 | 14-5 | 1 | 18,178 | Bob Welch | Clay Parker | Bob Welch | Clay Parker | | 94 | 70 | 24 |
| 1990-05-01 | @ NYA | 20 | W 4-2 | 15-5 | 1 | 22,018 | Mike Moore | Andy Hawkins | Mike Moore | Andy Hawkins | Dennis Eckersley | 98 | 72 | 26 |
| 1990-05-02 | @ NYA | 21 | W 2-0 | 16-5 | 1 | 21,475 | Scott Sanderson | Tim Leary | Scott Sanderson | Tim Leary | Rick Honeycutt | 100 | 72 | 28 |
| 1990-05-04 | vs BOS | 22 | W 8-3 | 17-5 | 1 | 43,894 | Dave Stewart | Roger Clemens | Dave Stewart | Roger Clemens | | 108 | 75 | 33 |
| 1990-05-05 | vs BOS | 23 | L 1-5 | 17-6 | 1 | 41,850 | Bob Welch | Mike Boddicker | Mike Boddicker | Bob Welch | | 109 | 80 | 29 |
| 1990-05-06 | vs BOS | 24 | W 4-2 | 18-6 | 1 | 44,008 | Curt Young | Eric Hetzel | Curt Young | Eric Hetzel | Dennis Eckersley | 113 | 82 | 31 |
| 1990-05-07 | vs NYA | 25 | W 5-1 | 19-6 | 1 | 30,304 | Mike Moore | Tim Leary | Mike Moore | Tim Leary | Todd Burns | 118 | 83 | 35 |
| 1990-05-08 | vs NYA | 26 | W 5-0 | 20-6 | 1 | 28,143 | Scott Sanderson | Greg Cadaret | Scott Sanderson | Greg Cadaret | Gene Nelson | 123 | 83 | 40 |
| 1990-05-09 | vs NYA | 27 | W 2-1 | 21-6 | 1 | 32,664 | Dave Stewart | Dave LaPoint | Rick Honeycutt | Eric Plunk | | 125 | 84 | 41 |
| 1990-05-11 | vs BAL | 28 | W 5-0 | 22-6 | 1 | 36,892 | Bob Welch | Bob Milacki | Bob Welch | Bob Milacki | | 130 | 84 | 46 |
| 1990-05-12 | vs BAL | 29 | L 2-3 | 22-7 | 1 | 40,958 | Curt Young | Dave Johnson | Mark Williamson | Gene Nelson | Gregg Olson | 132 | 87 | 45 |
| 1990-05-13 | vs BAL | 30 | L 1-4 | 22-8 | 1 | 36,394 | Mike Moore | Jay Tibbs | Jay Tibbs | Mike Moore | Gregg Olson | 133 | 91 | 42 |
| 1990-05-14 | @ MIN | 31 | L 2-6 | 22-9 | 1 | 18,966 | Dave Stewart | Allan Anderson | Allan Anderson | Dave Stewart | | 135 | 97 | 38 |
| 1990-05-15 | @ CLE | 32 | L 4-5 | 22-10 | 1 | 8,734 | Scott Sanderson | Greg Swindell | Cecilio Guante | Rick Honeycutt | Doug Jones | 139 | 102 | 37 |
| 1990-05-16 | @ CLE | 33 | W 7-6 | 23-10 | 1 | 10,706 | Bob Welch | Jeff Shaw | Dennis Eckersley | Doug Jones | | 146 | 108 | 38 |
| 1990-05-18 | @ MIL | 34 | L 0-5 | 23-11 | 1 | 23,580 | Mike Moore | Bill Wegman | Bill Wegman | Mike Moore | | 146 | 113 | 33 |
| 1990-05-19 | @ MIL | 35 | W 9-1 | 24-11 | 1 | 21,507 | Dave Stewart | Tom Filer | Dave Stewart | Tom Filer | Gene Nelson | 155 | 114 | 41 |
| 1990-05-20 | @ MIL | 36 | L 2-5 | 24-12 | 1 | 39,301 | Scott Sanderson | Chris Bosio | Chris Bosio | Scott Sanderson | | 157 | 119 | 38 |
| 1990-05-21 | @ TOR | 37 | W 4-1 | 25-12 | 1 | 49,471 | Bob Welch | Todd Stottlemyre | Bob Welch | Todd Stottlemyre | Dennis Eckersley | 161 | 120 | 41 |
| 1990-05-22 | @ TOR | 38 | W 5-4 | 26-12 | 1 | 49,559 | Curt Young | Jimmy Key | Curt Young | Frank Wills | Dennis Eckersley | 166 | 124 | 42 |
| 1990-05-23 | vs MIL | 39 | W 12-5 | 27-12 | 1 | 31,730 | Mike Moore | Bill Wegman | Mike Moore | Bill Wegman | | 178 | 129 | 49 |
| 1990-05-24 | vs MIL | 40 | W 13-1 | 28-12 | 1 | 27,091 | Dave Stewart | Tom Filer | Dave Stewart | Tom Filer | | 191 | 130 | 61 |
| 1990-05-25 | vs CLE | 41 | W 5-2 | 29-12 | 1 | 33,622 | Scott Sanderson | Greg Swindell | Scott Sanderson | Greg Swindell | Dennis Eckersley | 196 | 132 | 64 |
| 1990-05-26 | vs CLE | 42 | W 6-3 | 30-12 | 1 | 42,783 | Bob Welch | Sergio Valdez | Bob Welch | Sergio Valdez | Dennis Eckersley | 202 | 135 | 67 |
| 1990-05-28 | vs TOR | 43 | L 0-1 | 30-13 | 1 | 45,005 | Mike Moore | Dave Stieb | Dave Stieb | Mike Moore | | 202 | 136 | 66 |
| 1990-05-29 | vs TOR | 44 | L 1-2 | 30-14 | 1 | 25,255 | Dave Stewart | David Wells | David Wells | Dave Stewart | Tom Henke | 203 | 138 | 65 |
| 1990-05-30 | vs TOR | 45 | W 8-5 | 31-14 | 1 | 24,257 | Curt Young | Willie Blair | Todd Burns | Willie Blair | Dennis Eckersley | 211 | 143 | 68 |
| 1990-05-31 | @ KCA | 46 | W 6-4 | 32-14 | 1 | 37,341 | Bob Welch | Tom Gordon | Bob Welch | Tom Gordon | Dennis Eckersley | 217 | 147 | 70 |
| 1990-06-01 | @ KCA | 47 | W 4-3 | 33-14 | 1 | 29,820 | Scott Sanderson | Kevin Appier | Scott Sanderson | Kevin Appier | Dennis Eckersley | 221 | 150 | 71 |
| 1990-06-02 | @ KCA | 48 | L 4-10 | 33-15 | 1 | 40,052 | Mike Moore | Bret Saberhagen | Bret Saberhagen | Mike Moore | | 225 | 160 | 65 |
| 1990-06-03 | @ KCA | 49 | L 2-8 | 33-16 | 1 | 40,022 | Dave Stewart | Mark Gubicza | Mark Gubicza | Dave Stewart | | 227 | 168 | 59 |
| 1990-06-05 | @ TEX | 50 | W 7-4 | 34-16 | 1 | 23,055 | Bob Welch | Brian Bohanon | Bob Welch | Brian Bohanon | Dennis Eckersley | 234 | 172 | 62 |
| 1990-06-06 | @ TEX | 51 | W 5-4 | 35-16 | 1 | 30,639 | Scott Sanderson | Nolan Ryan | Scott Sanderson | Nolan Ryan | Dennis Eckersley | 239 | 176 | 63 |
| 1990-06-07 | @ TEX | 52 | L 1-3 | 35-17 | 1 | 26,129 | Mike Moore | Bobby Witt | Bobby Witt | Mike Moore | Kenny Rogers | 240 | 179 | 61 |
| 1990-06-08 | vs KCA | 53 | W 3-1 | 36-17 | 1 | 44,021 | Curt Young | Mark Gubicza | Curt Young | Mark Gubicza | Dennis Eckersley | 243 | 180 | 63 |
| 1990-06-09 | vs KCA | 54 | W 5-0 | 37-17 | 1 | 43,916 | Dave Stewart | Kevin Appier | Dave Stewart | Kevin Appier | | 248 | 180 | 68 |
| 1990-06-10 | vs KCA | 55 | W 3-2 | 38-17 | 1 | 43,700 | Bob Welch | Steve Farr | Bob Welch | Steve Farr | Dennis Eckersley | 251 | 182 | 69 |
| 1990-06-11 | vs TEX | 56 | L 0-5 | 38-18 | 1 | 33,436 | Scott Sanderson | Nolan Ryan | Nolan Ryan | Scott Sanderson | | 251 | 187 | 64 |
| 1990-06-12 | vs TEX | 57 | L 5-6 | 38-19 | 1 | 21,625 | Mike Moore | Bobby Witt | Brad Arnsberg | Dennis Eckersley | Kenny Rogers | 256 | 193 | 63 |
| 1990-06-13 | vs TEX | 58 | W 3-2 | 39-19 | 1 | 26,457 | Curt Young | Charlie Hough | Todd Burns | Brad Arnsberg | | 259 | 195 | 64 |
| 1990-06-14 | @ CHA | 59 | L 2-3 | 39-20 | 1 | 30,076 | Dave Stewart | Eric King | Eric King | Dave Stewart | Bobby Thigpen | 261 | 198 | 63 |
| 1990-06-15 | @ CHA | 60 | W 5-4 | 40-20 | 1 | 40,417 | Bob Welch | Greg Hibbard | Bob Welch | Barry Jones | Dennis Eckersley | 266 | 202 | 64 |
| 1990-06-16 | @ CHA | 61 | W 12-3 | 41-20 | 1 | 44,176 | Scott Sanderson | Melido Perez | Scott Sanderson | Melido Perez | | 278 | 205 | 73 |
| 1990-06-17 | @ CHA | 62 | W 5-2 | 42-20 | 1 | 32,283 | Mike Moore | Adam Peterson | Mike Moore | Donn Pall | Dennis Eckersley | 283 | 207 | 76 |
| 1990-06-18 | @ DET | 63 | L 2-7 | 42-21 | 1 | 18,551 | Curt Young | Jeff Robinson | Jeff Robinson | Curt Young | Ed Nunez | 285 | 214 | 71 |
| 1990-06-19 | @ DET | 64 | L 6-7 | 42-22 | 1 | 21,738 | Dave Stewart | Frank Tanana | Paul Gibson | Dave Stewart | Mike Henneman | 291 | 221 | 70 |
| 1990-06-20 | @ DET | 65 | W 12-7 | 43-22 | 1 | 24,799 | Bob Welch | Dan Petry | Bob Welch | Dan Petry | | 303 | 228 | 75 |
| 1990-06-22 | vs CHA | 66 | L 0-5 | 43-23 | 1 | 43,924 | Scott Sanderson | Eric King | Eric King | Scott Sanderson | | 303 | 233 | 70 |
| 1990-06-23 | vs CHA | 67 | L 3-5 | 43-24 | 1 | 43,084 | Mike Moore | Jack McDowell | Jack McDowell | Mike Moore | Bobby Thigpen | 306 | 238 | 68 |
| 1990-06-24 | vs CHA | 68 | L 2-3 | 43-25 | 1 | 44,347 | Dave Stewart | Melido Perez | Bobby Thigpen | Dave Stewart | Barry Jones | 308 | 241 | 67 |
| 1990-06-25 | vs DET | 69 | W 4-3 | 44-25 | 1 | 30,095 | Bob Welch | Dan Petry | Bob Welch | Dan Petry | Dennis Eckersley | 312 | 244 | 68 |
| 1990-06-26 | vs DET | 70 | W 3-2 | 45-25 | 1 | 31,643 | Scott Sanderson | Jack Morris | Scott Sanderson | Jack Morris | Dennis Eckersley | 315 | 246 | 69 |
| 1990-06-27 | vs DET | 71 | L 4-5 | 45-26 | 2 | 36,480 | Mike Moore | Brian Dubois | Mike Henneman | Todd Burns | | 319 | 251 | 68 |
| 1990-06-29 | @ TOR | 72 | W 5-0 | 46-26 | 2 | 49,817 | Dave Stewart | John Cerutti | Dave Stewart | John Cerutti | | 324 | 251 | 73 |
| 1990-06-30 | @ TOR | 73 | W 9-4 | 47-26 | 1 | 49,865 | Bob Welch | Dave Stieb | Bob Welch | Dave Stieb | | 333 | 255 | 78 |
| 1990-07-01 | @ TOR | 74 | L 3-4 | 47-27 | 2 | 49,857 | Scott Sanderson | David Wells | Willie Blair | Todd Burns | Tom Henke | 336 | 259 | 77 |
| 1990-07-02 | @ TOR | 75 | W 3-2 | 48-27 | 2 | 49,855 | Mike Moore | Jimmy Key | Mike Moore | Jimmy Key | Dennis Eckersley | 339 | 261 | 78 |
| 1990-07-03 | @ MIL | 76 | W 5-0 | 49-27 | 1 | 36,623 | Curt Young | Bill Krueger | Curt Young | Bill Krueger | | 344 | 261 | 83 |
| 1990-07-04 | @ MIL | 77 | L 1-7 | 49-28 | 1 | 15,030 | Dave Stewart | Ron Robinson | Ron Robinson | Dave Stewart | | 345 | 268 | 77 |
| 1990-07-05 | @ MIL | 78 | L 3-4 | 49-29 | 1 | 31,022 | Bob Welch | Teddy Higuera | Teddy Higuera | Bob Welch | Dan Plesac | 348 | 272 | 76 |
| 1990-07-06 | @ CLE | 79 | L 1-6 | 50-30 | 2 | 0 | Scott Sanderson | Greg Swindell | Greg Swindell | Scott Sanderson | | 349 | 278 | 71 |
| 1990-07-06 | @ CLE | 80 | W 12-1 | 50-30 | 2 | 45,705 | Mike Moore | Sergio Valdez | Mike Moore | Sergio Valdez | | 361 | 279 | 82 |
| 1990-07-07 | @ CLE | 81 | L 0-1 | 50-31 | 2 | 49,989 | Curt Young | Buddy Black | Buddy Black | Curt Young | | 361 | 280 | 81 |
| 1990-07-08 | @ CLE | 82 | W 8-3 | 51-31 | 1 | 31,299 | Dave Stewart | Al Nipper | Dave Stewart | Al Nipper | | 369 | 283 | 86 |
| 1990-07-11 | @ MIN | 83 | W 11-7 | 52-31 | 1 | 20,948 | Scott Sanderson | Allan Anderson | Scott Sanderson | Allan Anderson | Dennis Eckersley | 380 | 290 | 90 |
| 1990-07-12 | vs MIL | 84 | W 5-3 | 53-31 | 1 | 31,055 | Mike Moore | Teddy Higuera | Mike Moore | Teddy Higuera | Dennis Eckersley | 385 | 293 | 92 |
| 1990-07-13 | vs MIL | 85 | L 0-2 | 53-32 | 1 | 39,200 | Dave Stewart | Mark Knudson | Mark Knudson | Dave Stewart | | 385 | 295 | 90 |
| 1990-07-14 | vs MIL | 86 | W 3-1 | 54-32 | 1 | 43,612 | Bob Welch | Bill Krueger | Bob Welch | Bill Krueger | Dennis Eckersley | 388 | 296 | 92 |
| 1990-07-15 | vs MIL | 87 | W 4-1 | 55-32 | 1 | 43,797 | Curt Young | Chris Bosio | Curt Young | Chris Bosio | Rick Honeycutt | 392 | 297 | 95 |
| 1990-07-16 | vs CLE | 88 | W 3-0 | 56-32 | 1 | 28,079 | Scott Sanderson | Al Nipper | Scott Sanderson | Al Nipper | Gene Nelson | 395 | 297 | 98 |
| 1990-07-17 | vs CLE | 89 | L 2-4 | 56-33 | 1 | 26,811 | Mike Moore | Greg Swindell | Greg Swindell | Mike Moore | Doug Jones | 397 | 301 | 96 |
| 1990-07-18 | vs CLE | 90 | W 4-1 | 58-33 | 1 | 0 | Bob Welch | Tom Candiotti | Bob Welch | Tom Candiotti | Dennis Eckersley | 401 | 302 | 99 |
| 1990-07-18 | vs CLE | 91 | W 5-2 | 58-33 | 1 | 38,958 | Dave Stewart | Rod Nichols | Dave Stewart | Rod Nichols | Dennis Eckersley | 406 | 304 | 102 |
| 1990-07-20 | vs TOR | 92 | L 6-8 | 58-34 | 1 | 40,171 | Curt Young | John Cerutti | John Cerutti | Curt Young | Tom Henke | 412 | 312 | 100 |
| 1990-07-21 | vs TOR | 93 | L 1-2 | 58-35 | 1 | 43,097 | Scott Sanderson | Dave Stieb | Dave Stieb | Scott Sanderson | Tom Henke | 413 | 314 | 99 |
| 1990-07-22 | vs TOR | 94 | W 3-0 | 59-35 | 1 | 43,821 | Mike Moore | Jimmy Key | Mike Moore | Jimmy Key | Rick Honeycutt | 416 | 314 | 102 |
| 1990-07-23 | vs CAL | 95 | W 7-6 | 60-35 | 1 | 31,252 | Dave Stewart | Kirk McCaskill | Gene Nelson | Cliff Young | | 423 | 320 | 103 |
| 1990-07-24 | vs CAL | 96 | W 5-3 | 61-35 | 1 | 37,906 | Bob Welch | Jim Abbott | Bob Welch | Jim Abbott | Dennis Eckersley | 428 | 323 | 105 |
| 1990-07-25 | vs CAL | 97 | W 13-3 | 62-35 | 1 | 35,587 | Curt Young | Bert Blyleven | Curt Young | Bert Blyleven | Todd Burns | 441 | 326 | 115 |
| 1990-07-26 | vs CAL | 98 | L 2-4 | 62-36 | 1 | 35,188 | Scott Sanderson | Chuck Finley | Bryan Harvey | Dennis Eckersley | | 443 | 330 | 113 |
| 1990-07-27 | @ MIN | 99 | L 4-9 | 62-37 | 1 | 30,744 | Mike Moore | Roy Smith | Roy Smith | Mike Moore | | 447 | 339 | 108 |
| 1990-07-28 | @ MIN | 100 | W 4-1 | 63-38 | 1 | 0 | Dave Stewart | Mark Guthrie | Dave Stewart | Mark Guthrie | | 451 | 340 | 111 |
| 1990-07-28 | @ MIN | 101 | L 4-9 | 63-38 | 1 | 51,017 | Bob Welch | Scott Erickson | Scott Erickson | Bob Welch | | 455 | 349 | 106 |
| 1990-07-29 | @ MIN | 102 | L 5-6 | 63-39 | 1 | 33,588 | Curt Young | David West | Rick Aguilera | Rick Honeycutt | | 460 | 355 | 105 |
| 1990-07-30 | vs SEA | 103 | W 6-2 | 64-39 | 1 | 41,752 | Scott Sanderson | Randy Johnson | Rick Honeycutt | Randy Johnson | Dennis Eckersley | 466 | 357 | 109 |
| 1990-07-31 | vs SEA | 104 | L 2-7 | 64-40 | 1 | 30,130 | Mike Moore | Bill Swift | Bill Swift | Mike Moore | | 468 | 364 | 104 |
| 1990-08-01 | vs SEA | 105 | W 1-0 | 65-40 | 1 | 31,509 | Dave Stewart | Erik Hanson | Dave Stewart | Mike Schooler | | 469 | 364 | 105 |
| 1990-08-02 | @ CAL | 106 | W 7-5 | 66-40 | 1 | 38,698 | Bob Welch | Kirk McCaskill | Bob Welch | Kirk McCaskill | Dennis Eckersley | 476 | 369 | 107 |
| 1990-08-03 | @ CAL | 107 | W 8-6 | 67-40 | 1 | 45,457 | Scott Sanderson | Jim Abbott | Reggie Harris | Willie Fraser | Dennis Eckersley | 484 | 375 | 109 |
| 1990-08-04 | @ CAL | 108 | L 5-6 | 67-41 | 1 | 52,774 | Mike Moore | Joe Grahe | Mark Eichhorn | Todd Burns | | 489 | 381 | 108 |
| 1990-08-05 | @ CAL | 109 | W 4-1 | 68-41 | 1 | 51,597 | Dave Stewart | Chuck Finley | Dave Stewart | Chuck Finley | Dennis Eckersley | 493 | 382 | 111 |
| 1990-08-07 | vs BAL | 110 | W 3-2 | 69-41 | 1 | 40,117 | Bob Welch | John Mitchell | Bob Welch | John Mitchell | Dennis Eckersley | 496 | 384 | 112 |
| 1990-08-08 | vs BAL | 111 | L 1-4 | 69-42 | 1 | 30,739 | Scott Sanderson | Ben McDonald | Ben McDonald | Scott Sanderson | Gregg Olson | 497 | 388 | 109 |
| 1990-08-09 | vs BAL | 112 | W 5-2 | 70-42 | 1 | 28,008 | Mike Moore | Dave Johnson | Mike Moore | Dave Johnson | Dennis Eckersley | 502 | 390 | 112 |
| 1990-08-10 | vs NYA | 113 | W 3-0 | 71-42 | 1 | 44,400 | Dave Stewart | Dave LaPoint | Dave Stewart | Dave LaPoint | Rick Honeycutt | 505 | 390 | 115 |
| 1990-08-11 | vs NYA | 114 | W 10-1 | 72-42 | 1 | 43,479 | Curt Young | Andy Hawkins | Curt Young | Andy Hawkins | Gene Nelson | 515 | 391 | 124 |
| 1990-08-12 | vs NYA | 115 | W 6-1 | 73-42 | 1 | 44,192 | Bob Welch | Mike Witt | Bob Welch | Mike Witt | Rick Honeycutt | 521 | 392 | 129 |
| 1990-08-13 | vs BOS | 116 | W 4-0 | 74-42 | 1 | 34,758 | Scott Sanderson | Greg Harris | Scott Sanderson | Greg Harris | | 525 | 392 | 133 |
| 1990-08-14 | vs BOS | 117 | L 0-2 | 74-43 | 1 | 38,009 | Mike Moore | Roger Clemens | Roger Clemens | Mike Moore | | 525 | 394 | 131 |
| 1990-08-15 | vs BOS | 118 | W 6-2 | 75-43 | 1 | 41,704 | Dave Stewart | Dana Kiecker | Dave Stewart | Daryl Irvine | | 531 | 396 | 135 |
| 1990-08-17 | @ BAL | 119 | W 8-3 | 76-43 | 1 | 45,379 | Bob Welch | John Mitchell | Bob Welch | John Mitchell | | 539 | 399 | 140 |
| 1990-08-18 | @ BAL | 120 | W 3-1 | 77-43 | 1 | 49,417 | Curt Young | Ben McDonald | Gene Nelson | Ben McDonald | Dennis Eckersley | 542 | 400 | 142 |
| 1990-08-19 | @ BAL | 121 | L 2-3 | 77-44 | 1 | 47,756 | Scott Sanderson | Anthony Telford | Anthony Telford | Scott Sanderson | Gregg Olson | 544 | 403 | 141 |
| 1990-08-20 | @ CHA | 122 | L 1-11 | 77-45 | 1 | 39,294 | Dave Stewart | Jack McDowell | Jack McDowell | Dave Stewart | | 545 | 414 | 131 |
| 1990-08-21 | @ CHA | 123 | L 1-4 | 77-46 | 1 | 31,172 | Mike Moore | Greg Hibbard | Greg Hibbard | Mike Moore | Bobby Thigpen | 546 | 418 | 128 |
| 1990-08-22 | @ CHA | 124 | W 7-1 | 78-46 | 1 | 33,858 | Bob Welch | Melido Perez | Bob Welch | Melido Perez | | 553 | 419 | 134 |
| 1990-08-24 | @ DET | 125 | W 6-4 | 79-46 | 1 | 29,613 | Scott Sanderson | Walt Terrell | Scott Sanderson | Walt Terrell | Dennis Eckersley | 559 | 423 | 136 |
| 1990-08-25 | @ DET | 126 | L 4-14 | 79-47 | 1 | 45,474 | Dave Stewart | Frank Tanana | Frank Tanana | Dave Stewart | | 563 | 437 | 126 |
| 1990-08-26 | @ DET | 127 | L 3-7 | 79-48 | 1 | 24,630 | Bob Welch | Jeff Robinson | Jeff Robinson | Bob Welch | | 566 | 444 | 122 |
| 1990-08-28 | vs KCA | 128 | W 3-2 | 80-48 | 1 | 34,924 | Mike Moore | Tom Gordon | Mike Moore | Jeff Montgomery | | 569 | 446 | 123 |
| 1990-08-29 | vs KCA | 129 | L 0-6 | 80-49 | 1 | 30,002 | Scott Sanderson | Kevin Appier | Kevin Appier | Scott Sanderson | | 569 | 452 | 117 |
| 1990-08-30 | vs KCA | 130 | W 6-5 | 81-49 | 1 | 36,856 | Dave Stewart | Andy McGaffigan | Dennis Eckersley | Steve Crawford | | 575 | 457 | 118 |
| 1990-08-31 | vs TEX | 131 | W 4-2 | 82-49 | 1 | 35,306 | Bob Welch | Jamie Moyer | Bob Welch | Jamie Moyer | Dennis Eckersley | 579 | 459 | 120 |
| 1990-09-01 | vs TEX | 132 | L 2-3 | 82-50 | 1 | 43,375 | Curt Young | Bobby Witt | Bobby Witt | Curt Young | Kenny Rogers | 581 | 462 | 119 |
| 1990-09-02 | vs TEX | 133 | W 4-2 | 83-50 | 1 | 42,863 | Mike Moore | Charlie Hough | Mike Moore | Charlie Hough | Dennis Eckersley | 585 | 464 | 121 |
| 1990-09-03 | @ BOS | 134 | W 9-5 | 84-50 | 1 | 34,692 | Scott Sanderson | Dana Kiecker | Scott Sanderson | Dana Kiecker | | 594 | 469 | 125 |
| 1990-09-04 | @ BOS | 135 | W 6-2 | 85-50 | 1 | 35,408 | Dave Stewart | Roger Clemens | Dave Stewart | Roger Clemens | | 600 | 471 | 129 |
| 1990-09-05 | @ BOS | 136 | W 10-0 | 86-50 | 1 | 33,156 | Bob Welch | Greg Harris | Bob Welch | Greg Harris | | 610 | 471 | 139 |
| 1990-09-07 | @ NYA | 137 | W 7-1 | 87-50 | 1 | 27,034 | Curt Young | Andy Hawkins | Curt Young | Andy Hawkins | Todd Burns | 617 | 472 | 145 |
| 1990-09-08 | @ NYA | 138 | W 5-2 | 88-50 | 1 | 35,721 | Scott Sanderson | Mike Witt | Scott Sanderson | Mike Witt | Dennis Eckersley | 622 | 474 | 148 |
| 1990-09-09 | @ NYA | 139 | W 7-3 | 89-50 | 1 | 36,391 | Dave Stewart | Tim Leary | Dave Stewart | Tim Leary | | 629 | 477 | 152 |
| 1990-09-10 | @ SEA | 140 | L 2-5 | 89-51 | 1 | 25,129 | Bob Welch | Erik Hanson | Erik Hanson | Bob Welch | Keith Comstock | 631 | 482 | 149 |
| 1990-09-11 | @ SEA | 141 | W 10-2 | 90-51 | 1 | 17,867 | Curt Young | Randy Johnson | Curt Young | Randy Johnson | | 641 | 484 | 157 |
| 1990-09-12 | @ SEA | 142 | W 9-3 | 91-51 | 1 | 14,427 | Scott Sanderson | Mike Gardiner | Scott Sanderson | Mike Gardiner | | 650 | 487 | 163 |
| 1990-09-13 | vs MIN | 143 | L 1-3 | 91-52 | 1 | 26,622 | Todd Burns | Scott Erickson | Juan Berenguer | Gene Nelson | | 651 | 490 | 161 |
| 1990-09-14 | vs MIN | 144 | W 9-1 | 92-52 | 1 | 34,091 | Dave Stewart | Mark Guthrie | Dave Stewart | Mark Guthrie | | 660 | 491 | 169 |
| 1990-09-15 | vs MIN | 145 | W 4-1 | 93-52 | 1 | 43,151 | Bob Welch | Paul Abbott | Bob Welch | Paul Abbott | Dennis Eckersley | 664 | 492 | 172 |
| 1990-09-16 | vs MIN | 146 | W 5-4 | 94-52 | 1 | 38,043 | Curt Young | Kevin Tapani | Dennis Eckersley | Juan Berenguer | | 669 | 496 | 173 |
| 1990-09-17 | vs CHA | 147 | L 0-7 | 94-53 | 1 | 43,953 | Scott Sanderson | Melido Perez | Melido Perez | Scott Sanderson | | 669 | 503 | 166 |
| 1990-09-18 | vs CHA | 148 | L 2-8 | 94-54 | 1 | 33,728 | Mike Moore | Alex Fernandez | Alex Fernandez | Mike Moore | | 671 | 511 | 160 |
| 1990-09-19 | vs CHA | 149 | W 7-3 | 95-54 | 1 | 35,990 | Dave Stewart | Jack McDowell | Dave Stewart | Jack McDowell | | 678 | 514 | 164 |
| 1990-09-21 | vs DET | 150 | W 6-5 | 96-54 | 1 | 41,356 | Bob Welch | Frank Tanana | Bob Welch | Clay Parker | Dennis Eckersley | 684 | 519 | 165 |
| 1990-09-22 | vs DET | 151 | W 5-1 | 97-54 | 1 | 40,904 | Scott Sanderson | Steve Searcy | Scott Sanderson | Steve Searcy | Rick Honeycutt | 689 | 520 | 169 |
| 1990-09-23 | vs DET | 152 | L 0-6 | 97-55 | 1 | 43,666 | Mike Moore | Jack Morris | Jack Morris | Mike Moore | | 689 | 526 | 163 |
| 1990-09-24 | @ KCA | 153 | L 3-10 | 97-56 | 1 | 27,630 | Curt Young | Tom Gordon | Tom Gordon | Curt Young | | 692 | 536 | 156 |
| 1990-09-25 | @ KCA | 154 | W 5-0 | 98-56 | 1 | 22,145 | Dave Stewart | Kevin Appier | Dave Stewart | Kevin Appier | | 697 | 536 | 161 |
| 1990-09-26 | @ KCA | 155 | W 3-2 | 99-56 | 1 | 27,535 | Bob Welch | Bret Saberhagen | Bob Welch | Bret Saberhagen | Dennis Eckersley | 700 | 538 | 162 |
| 1990-09-27 | @ TEX | 156 | L 6-8 | 99-57 | 1 | 16,857 | Scott Sanderson | Scott Chiamparino | Scott Chiamparino | Scott Sanderson | Jeff Russell | 706 | 546 | 160 |
| 1990-09-28 | @ TEX | 157 | W 4-1 | 100-57 | 1 | 27,477 | Mike Moore | Charlie Hough | Mike Moore | Charlie Hough | Dennis Eckersley | 710 | 547 | 163 |
| 1990-09-29 | @ TEX | 158 | W 7-3 | 101-57 | 1 | 37,260 | Todd Burns | Craig McMurtry | Todd Burns | Craig McMurtry | Dennis Eckersley | 717 | 550 | 167 |
| 1990-09-30 | @ TEX | 159 | W 4-3 | 102-57 | 1 | 35,912 | Reggie Harris | Nolan Ryan | Steve Chitren | Nolan Ryan | Joe Klink | 721 | 553 | 168 |
| 1990-10-01 | vs CAL | 160 | L 0-2 | 102-58 | 1 | 31,378 | Dave Stewart | Joe Grahe | Joe Grahe | Dave Stewart | Bryan Harvey | 721 | 555 | 166 |
| 1990-10-02 | vs CAL | 161 | W 6-4 | 103-58 | 1 | 29,042 | Bob Welch | Jim Abbott | Bob Welch | Willie Fraser | Dennis Eckersley | 727 | 559 | 168 |
| 1990-10-03 | vs CAL | 162 | L 6-11 | 103-59 | 1 | 24,225 | Mike Moore | Mike Fetters | Cliff Young | Mike Moore | | 733 | 570 | 163 |