| 1990-04-12 | vs CLE | 1 | W 6-4 | 1-0 | 1 | 50,114 | Dave LaPoint | Buddy Black | Eric Plunk | Jesse Orosco | | 6 | 4 | 2 |
| 1990-04-13 | vs TEX | 2 | W 3-0 | 2-0 | 1 | 21,505 | Pascual Perez | Bobby Witt | Pascual Perez | Bobby Witt | Dave Righetti | 9 | 4 | 5 |
| 1990-04-14 | vs TEX | 3 | L 4-8 | 2-1 | 2 | 24,085 | Andy Hawkins | Nolan Ryan | Nolan Ryan | Andy Hawkins | | 13 | 12 | 1 |
| 1990-04-15 | vs TEX | 4 | W 3-1 | 3-1 | 1 | 22,268 | Greg Cadaret | Charlie Hough | Eric Plunk | Jeff Russell | Dave Righetti | 16 | 13 | 3 |
| 1990-04-17 | @ DET | 5 | W 4-1 | 4-1 | 1 | 11,595 | Tim Leary | Frank Tanana | Tim Leary | Frank Tanana | Dave Righetti | 20 | 14 | 6 |
| 1990-04-18 | @ DET | 6 | L 4-8 | 4-2 | 1 | 14,515 | Dave LaPoint | Jack Morris | Jack Morris | Dave LaPoint | Mike Henneman | 24 | 22 | 2 |
| 1990-04-19 | @ CLE | 7 | L 0-1 | 4-3 | 2 | 6,000 | Pascual Perez | Greg Swindell | Greg Swindell | Pascual Perez | Doug Jones | 24 | 23 | 1 |
| 1990-04-20 | @ TEX | 8 | L 5-6 | 4-4 | 5 | 26,648 | Andy Hawkins | Nolan Ryan | Nolan Ryan | Lee Guetterman | Jeff Russell | 29 | 29 | 0 |
| 1990-04-21 | @ TEX | 9 | L 6-9 | 4-5 | 6 | 35,453 | Greg Cadaret | Charlie Hough | Charlie Hough | Greg Cadaret | Jeff Russell | 35 | 38 | -3 |
| 1990-04-22 | @ TEX | 10 | L 4-10 | 4-6 | 6 | 30,717 | Tim Leary | Kevin Brown | Kevin Brown | Tim Leary | Jeff Russell | 39 | 48 | -9 |
| 1990-04-24 | vs SEA | 11 | W 6-2 | 5-6 | 5 | 17,018 | Dave LaPoint | Matt Young | Dave LaPoint | Matt Young | | 45 | 50 | -5 |
| 1990-04-25 | vs SEA | 12 | L 2-5 | 5-7 | 6 | 15,537 | Pascual Perez | Brian Holman | Brian Holman | Pascual Perez | Mike Schooler | 47 | 55 | -8 |
| 1990-04-26 | vs SEA | 13 | L 2-6 | 5-8 | 7 | 15,857 | Andy Hawkins | Randy Johnson | Randy Johnson | Andy Hawkins | Bill Swift | 49 | 61 | -12 |
| 1990-04-27 | vs CAL | 14 | W 5-4 | 6-8 | 5 | 20,289 | Tim Leary | Bert Blyleven | Lee Guetterman | Willie Fraser | Dave Righetti | 54 | 65 | -11 |
| 1990-04-28 | vs CAL | 15 | W 3-2 | 7-8 | 5 | 25,751 | Greg Cadaret | Chuck Finley | Greg Cadaret | Chuck Finley | Dave Righetti | 57 | 67 | -10 |
| 1990-04-29 | vs CAL | 16 | L 3-4 | 7-9 | 5 | 30,098 | Dave LaPoint | Mark Langston | Mark Langston | Dave LaPoint | Bryan Harvey | 60 | 71 | -11 |
| 1990-04-30 | vs OAK | 17 | L 0-6 | 7-10 | 6 | 18,178 | Clay Parker | Bob Welch | Bob Welch | Clay Parker | | 60 | 77 | -17 |
| 1990-05-01 | vs OAK | 18 | L 2-4 | 7-11 | 6 | 22,018 | Andy Hawkins | Mike Moore | Mike Moore | Andy Hawkins | Dennis Eckersley | 62 | 81 | -19 |
| 1990-05-02 | vs OAK | 19 | L 0-2 | 7-12 | 6 | 21,475 | Tim Leary | Scott Sanderson | Scott Sanderson | Tim Leary | Rick Honeycutt | 62 | 83 | -21 |
| 1990-05-03 | vs CLE | 20 | L 5-10 | 7-13 | 6 | 15,169 | Greg Cadaret | John Farrell | Jesse Orosco | Jeff Robinson | Doug Jones | 67 | 93 | -26 |
| 1990-05-04 | @ CAL | 21 | W 5-2 | 8-13 | 6 | 36,703 | Dave LaPoint | Mark Langston | Dave LaPoint | Mark Langston | | 72 | 95 | -23 |
| 1990-05-05 | @ CAL | 22 | W 11-3 | 9-13 | 6 | 47,933 | Clay Parker | Kirk McCaskill | Clay Parker | Kirk McCaskill | | 83 | 98 | -15 |
| 1990-05-06 | @ CAL | 23 | W 4-2 | 10-13 | 5 | 50,717 | Andy Hawkins | Jim Abbott | Andy Hawkins | Jim Abbott | Dave Righetti | 87 | 100 | -13 |
| 1990-05-07 | @ OAK | 24 | L 1-5 | 10-14 | 6 | 30,304 | Tim Leary | Mike Moore | Mike Moore | Tim Leary | Todd Burns | 88 | 105 | -17 |
| 1990-05-08 | @ OAK | 25 | L 0-5 | 10-15 | 6 | 28,143 | Greg Cadaret | Scott Sanderson | Scott Sanderson | Greg Cadaret | Gene Nelson | 88 | 110 | -22 |
| 1990-05-09 | @ OAK | 26 | L 1-2 | 10-16 | 6 | 32,664 | Dave LaPoint | Dave Stewart | Rick Honeycutt | Eric Plunk | | 89 | 112 | -23 |
| 1990-05-11 | @ SEA | 27 | W 8-5 | 11-16 | 6 | 26,699 | Andy Hawkins | Randy Johnson | Lee Guetterman | Gene Harris | Dave Righetti | 97 | 117 | -20 |
| 1990-05-12 | @ SEA | 28 | W 4-1 | 12-16 | 6 | 43,977 | Tim Leary | Erik Hanson | Tim Leary | Erik Hanson | | 101 | 118 | -17 |
| 1990-05-13 | @ SEA | 29 | L 5-10 | 12-17 | 6 | 18,492 | Greg Cadaret | Matt Young | Matt Young | Greg Cadaret | | 106 | 128 | -22 |
| 1990-05-15 | vs MIN | 30 | W 7-3 | 13-17 | 6 | 16,586 | Chuck Cary | Roy Smith | Chuck Cary | Roy Smith | | 113 | 131 | -18 |
| 1990-05-17 | vs MIN | 31 | L 1-4 | 13-18 | 5 | 16,267 | Dave LaPoint | Kevin Tapani | Kevin Tapani | Dave LaPoint | Rick Aguilera | 114 | 135 | -21 |
| 1990-05-18 | vs KCA | 32 | L 1-4 | 13-19 | 6 | 30,112 | Tim Leary | Bret Saberhagen | Bret Saberhagen | Tim Leary | | 115 | 139 | -24 |
| 1990-05-19 | vs KCA | 33 | W 5-4 | 14-19 | 5 | 35,473 | Mike Witt | Mark Gubicza | Lance McCullers | Steve Farr | | 120 | 143 | -23 |
| 1990-05-20 | vs KCA | 34 | L 3-4 | 14-20 | 7 | 22,327 | Chuck Cary | Storm Davis | Jeff Montgomery | Jeff Robinson | | 123 | 147 | -24 |
| 1990-05-21 | vs CHA | 35 | L 5-6 | 14-21 | 7 | 14,313 | Andy Hawkins | Jerry Kutzler | Scott Radinsky | Lee Guetterman | Bobby Thigpen | 128 | 153 | -25 |
| 1990-05-22 | vs CHA | 36 | W 5-2 | 15-21 | 7 | 24,142 | Dave LaPoint | Melido Perez | Dave LaPoint | Melido Perez | Dave Righetti | 133 | 155 | -22 |
| 1990-05-23 | @ MIN | 37 | W 12-0 | 16-21 | 6 | 17,195 | Tim Leary | Tim Drummond | Tim Leary | Tim Drummond | | 145 | 155 | -10 |
| 1990-05-24 | @ MIN | 38 | L 4-5 | 16-22 | 6 | 19,649 | Mike Witt | Allan Anderson | Rick Aguilera | Greg Cadaret | | 149 | 160 | -11 |
| 1990-05-25 | @ KCA | 39 | W 6-3 | 17-22 | 6 | 27,601 | Chuck Cary | Storm Davis | Chuck Cary | Storm Davis | Dave Righetti | 155 | 163 | -8 |
| 1990-05-26 | @ KCA | 40 | L 4-9 | 17-23 | 7 | 35,322 | Andy Hawkins | Tom Gordon | Tom Gordon | Andy Hawkins | | 159 | 172 | -13 |
| 1990-05-27 | @ KCA | 41 | L 2-6 | 17-24 | 7 | 32,352 | Dave LaPoint | Kevin Appier | Kevin Appier | Dave LaPoint | Jeff Montgomery | 161 | 178 | -17 |
| 1990-05-28 | @ CHA | 42 | L 1-2 | 17-25 | 7 | 25,008 | Tim Leary | Eric King | Eric King | Tim Leary | Bobby Thigpen | 162 | 180 | -18 |
| 1990-05-29 | @ CHA | 43 | L 4-5 | 17-26 | 7 | 15,353 | Mike Witt | Jack McDowell | Bobby Thigpen | Jeff Robinson | | 166 | 185 | -19 |
| 1990-05-30 | @ CHA | 44 | L 2-5 | 17-27 | 7 | 18,585 | Chuck Cary | Greg Hibbard | Greg Hibbard | Chuck Cary | Bobby Thigpen | 168 | 190 | -22 |
| 1990-06-01 | vs BAL | 45 | W 4-3 | 18-27 | 7 | 28,191 | Dave LaPoint | Jeff Ballard | Dave LaPoint | Jeff Ballard | Dave Righetti | 172 | 193 | -21 |
| 1990-06-02 | vs BAL | 46 | L 2-4 | 18-28 | 7 | 27,569 | Tim Leary | Dave Johnson | Dave Johnson | Tim Leary | Gregg Olson | 174 | 197 | -23 |
| 1990-06-03 | vs BAL | 47 | L 3-4 | 18-29 | 7 | 42,673 | Mike Witt | Bob Milacki | Bob Milacki | Mike Witt | Gregg Olson | 177 | 201 | -24 |
| 1990-06-04 | @ BOS | 48 | L 3-5 | 18-30 | 7 | 32,125 | Chuck Cary | Dana Kiecker | Jeff Reardon | Jeff Robinson | | 180 | 206 | -26 |
| 1990-06-05 | @ BOS | 49 | L 8-9 | 18-31 | 7 | 32,919 | Andy Hawkins | John Dopson | Jeff Reardon | Eric Plunk | Jerry Reed | 188 | 215 | -27 |
| 1990-06-06 | @ BOS | 50 | L 1-4 | 18-32 | 7 | 33,385 | Dave LaPoint | Mike Boddicker | Mike Boddicker | Dave LaPoint | | 189 | 219 | -30 |
| 1990-06-07 | @ BOS | 51 | L 0-3 | 18-33 | 7 | 33,454 | Tim Leary | Greg Harris | Greg Harris | Tim Leary | Jeff Reardon | 189 | 222 | -33 |
| 1990-06-08 | @ BAL | 52 | L 4-5 | 18-34 | 7 | 44,347 | Mike Witt | Bob Milacki | Brian Holton | Alan Mills | | 193 | 227 | -34 |
| 1990-06-09 | @ BAL | 53 | L 1-10 | 18-35 | 7 | 45,092 | Chuck Cary | Pete Harnisch | Pete Harnisch | Chuck Cary | | 194 | 237 | -43 |
| 1990-06-10 | @ BAL | 54 | W 5-2 | 19-35 | 7 | 47,617 | Jimmy Jones | Jay Tibbs | Jimmy Jones | Jay Tibbs | Dave Righetti | 199 | 239 | -40 |
| 1990-06-12 | vs BOS | 55 | W 5-4 | 20-35 | 7 | 31,706 | Dave LaPoint | Greg Harris | Lee Guetterman | Rob Murphy | Dave Righetti | 204 | 243 | -39 |
| 1990-06-13 | vs BOS | 56 | L 1-4 | 20-36 | 7 | 28,623 | Tim Leary | Roger Clemens | Roger Clemens | Tim Leary | Jeff Reardon | 205 | 247 | -42 |
| 1990-06-14 | vs BOS | 57 | W 3-1 | 21-36 | 7 | 27,073 | Chuck Cary | Dana Kiecker | Chuck Cary | Dana Kiecker | Dave Righetti | 208 | 248 | -40 |
| 1990-06-15 | vs TOR | 58 | L 4-5 | 21-37 | 7 | 31,827 | Jimmy Jones | David Wells | David Wells | Jeff Robinson | Tom Henke | 212 | 253 | -41 |
| 1990-06-16 | vs TOR | 59 | L 1-2 | 21-38 | 7 | 26,061 | Andy Hawkins | Willie Blair | Frank Wills | Alan Mills | Duane Ward | 213 | 255 | -42 |
| 1990-06-17 | vs TOR | 60 | L 1-8 | 21-39 | 7 | 38,173 | Dave LaPoint | Todd Stottlemyre | Todd Stottlemyre | Dave LaPoint | | 214 | 263 | -49 |
| 1990-06-18 | @ MIL | 61 | L 2-4 | 21-40 | 7 | 18,389 | Tim Leary | Mark Knudson | Mark Knudson | Tim Leary | Chuck Crim | 216 | 267 | -51 |
| 1990-06-19 | @ MIL | 62 | W 5-1 | 22-40 | 7 | 21,268 | Chuck Cary | Chris Bosio | Chuck Cary | Chris Bosio | | 221 | 268 | -47 |
| 1990-06-20 | @ MIL | 63 | W 5-4 | 23-40 | 7 | 29,795 | Jimmy Jones | Dennis Powell | Lee Guetterman | Chuck Crim | | 226 | 272 | -46 |
| 1990-06-21 | @ TOR | 64 | W 7-6 | 24-40 | 7 | 49,883 | Andy Hawkins | David Wells | Alan Mills | Jim Acker | Dave Righetti | 233 | 278 | -45 |
| 1990-06-22 | @ TOR | 65 | W 8-7 | 25-40 | 7 | 49,908 | Dave LaPoint | Jimmy Key | Greg Cadaret | Willie Blair | Dave Righetti | 241 | 285 | -44 |
| 1990-06-23 | @ TOR | 66 | L 4-8 | 25-41 | 7 | 49,858 | Tim Leary | Todd Stottlemyre | Todd Stottlemyre | Tim Leary | Tom Henke | 245 | 293 | -48 |
| 1990-06-24 | @ TOR | 67 | L 3-8 | 25-42 | 7 | 49,806 | Chuck Cary | John Cerutti | John Cerutti | Chuck Cary | Jim Acker | 248 | 301 | -53 |
| 1990-06-26 | vs MIL | 68 | W 8-2 | 26-42 | 7 | 25,802 | Andy Hawkins | Dennis Powell | Lee Guetterman | Dennis Powell | | 256 | 303 | -47 |
| 1990-06-27 | vs MIL | 69 | L 4-5 | 26-43 | 7 | 18,652 | Jimmy Jones | Bill Krueger | Bill Krueger | Jimmy Jones | Chuck Crim | 260 | 308 | -48 |
| 1990-06-28 | vs MIL | 70 | W 3-2 | 27-43 | 7 | 23,643 | Tim Leary | Mark Knudson | Dave Righetti | Bob Sebra | | 263 | 310 | -47 |
| 1990-06-29 | @ CHA | 71 | L 0-1 | 27-44 | 7 | 30,137 | Chuck Cary | Jack McDowell | Jack McDowell | Chuck Cary | Bobby Thigpen | 263 | 311 | -48 |
| 1990-06-30 | @ CHA | 72 | W 10-7 | 28-44 | 7 | 38,078 | Dave LaPoint | Melido Perez | Jeff Robinson | Melido Perez | Dave Righetti | 273 | 318 | -45 |
| 1990-07-01 | @ CHA | 73 | L 0-4 | 28-45 | 7 | 30,642 | Andy Hawkins | Greg Hibbard | Barry Jones | Andy Hawkins | | 273 | 322 | -49 |
| 1990-07-02 | @ KCA | 74 | L 5-11 | 28-46 | 7 | 38,693 | Jimmy Jones | Kevin Appier | Kevin Appier | Jimmy Jones | | 278 | 333 | -55 |
| 1990-07-03 | @ KCA | 75 | L 1-6 | 28-47 | 7 | 27,529 | Tim Leary | Steve Farr | Steve Farr | Tim Leary | Jeff Montgomery | 279 | 339 | -60 |
| 1990-07-04 | @ KCA | 76 | L 6-13 | 28-48 | 7 | 38,323 | Chuck Cary | Bret Saberhagen | Steve Crawford | Lee Guetterman | | 285 | 352 | -67 |
| 1990-07-06 | vs MIN | 77 | L 0-2 | 29-49 | 7 | 0 | Andy Hawkins | Allan Anderson | Juan Berenguer | Andy Hawkins | Rick Aguilera | 285 | 354 | -69 |
| 1990-07-06 | vs MIN | 78 | W 5-3 | 29-49 | 7 | 25,120 | Dave LaPoint | Roy Smith | Dave LaPoint | Roy Smith | Dave Righetti | 290 | 357 | -67 |
| 1990-07-07 | vs MIN | 79 | W 5-4 | 30-49 | 7 | 30,201 | Jimmy Jones | Kevin Tapani | Lee Guetterman | Terry Leach | | 295 | 361 | -66 |
| 1990-07-08 | vs MIN | 80 | L 3-6 | 30-50 | 7 | 38,119 | Tim Leary | David West | David West | Tim Leary | Tim Drummond | 298 | 367 | -69 |
| 1990-07-12 | vs CHA | 81 | L 0-8 | 30-51 | 7 | 17,586 | Andy Hawkins | Melido Perez | Melido Perez | Andy Hawkins | | 298 | 375 | -77 |
| 1990-07-13 | vs CHA | 82 | L 2-3 | 30-52 | 7 | 20,202 | Chuck Cary | Greg Hibbard | Greg Hibbard | Chuck Cary | Bobby Thigpen | 300 | 378 | -78 |
| 1990-07-14 | vs CHA | 83 | L 7-8 | 30-53 | 7 | 41,513 | Tim Leary | Adam Peterson | Donn Pall | Lee Guetterman | Bobby Thigpen | 307 | 386 | -79 |
| 1990-07-15 | vs CHA | 84 | L 5-8 | 30-54 | 7 | 31,939 | Dave LaPoint | Eric King | Ken Patterson | Alan Mills | Bobby Thigpen | 312 | 394 | -82 |
| 1990-07-16 | vs KCA | 85 | W 3-2 | 31-54 | 7 | 20,718 | Jeff Robinson | Pete Filson | Jeff Robinson | Pete Filson | Dave Righetti | 315 | 396 | -81 |
| 1990-07-17 | vs KCA | 86 | L 7-10 | 31-55 | 7 | 26,777 | Andy Hawkins | Storm Davis | Storm Davis | Andy Hawkins | Jeff Montgomery | 322 | 406 | -84 |
| 1990-07-18 | vs KCA | 87 | W 5-3 | 32-55 | 7 | 32,246 | Chuck Cary | Tom Gordon | Eric Plunk | Steve Crawford | Dave Righetti | 327 | 409 | -82 |
| 1990-07-19 | @ MIN | 88 | W 2-1 | 33-55 | 7 | 29,988 | Tim Leary | Roy Smith | Tim Leary | Roy Smith | Dave Righetti | 329 | 410 | -81 |
| 1990-07-20 | @ MIN | 89 | L 1-2 | 33-56 | 7 | 25,146 | Dave LaPoint | Allan Anderson | Allan Anderson | Dave LaPoint | | 330 | 412 | -82 |
| 1990-07-21 | @ MIN | 90 | L 1-2 | 33-57 | 7 | 27,108 | Jeff Robinson | Mark Guthrie | Mark Guthrie | Jeff Robinson | Rick Aguilera | 331 | 414 | -83 |
| 1990-07-22 | @ MIN | 91 | W 10-6 | 34-57 | 7 | 29,238 | Andy Hawkins | Scott Erickson | Greg Cadaret | Rick Aguilera | | 341 | 420 | -79 |
| 1990-07-23 | @ TEX | 92 | L 2-3 | 34-58 | 7 | 22,008 | Chuck Cary | Kevin Brown | Kevin Brown | Chuck Cary | | 343 | 423 | -80 |
| 1990-07-24 | @ TEX | 93 | L 1-4 | 34-59 | 7 | 21,602 | Tim Leary | Bobby Witt | Bobby Witt | Tim Leary | | 344 | 427 | -83 |
| 1990-07-25 | @ TEX | 94 | L 7-9 | 34-60 | 7 | 41,954 | Dave LaPoint | Nolan Ryan | Kenny Rogers | Mark Leiter | | 351 | 436 | -85 |
| 1990-07-27 | @ CLE | 95 | W 3-0 | 36-60 | 7 | 0 | Andy Hawkins | Greg Swindell | Andy Hawkins | Greg Swindell | | 354 | 436 | -82 |
| 1990-07-27 | @ CLE | 96 | W 4-1 | 36-60 | 7 | 44,510 | Jeff Robinson | Mike Walker | Jeff Robinson | Mike Walker | Dave Righetti | 358 | 437 | -79 |
| 1990-07-28 | @ CLE | 97 | L 1-2 | 36-61 | 7 | 28,387 | Chuck Cary | Tom Candiotti | Tom Candiotti | Chuck Cary | Doug Jones | 359 | 439 | -80 |
| 1990-07-29 | @ CLE | 98 | W 8-5 | 38-61 | 7 | 0 | Tim Leary | Buddy Black | Tim Leary | Buddy Black | Greg Cadaret | 367 | 444 | -77 |
| 1990-07-29 | @ CLE | 99 | W 4-3 | 38-61 | 7 | 32,656 | Jimmy Jones | Cecilio Guante | Eric Plunk | Cecilio Guante | Greg Cadaret | 371 | 447 | -76 |
| 1990-07-30 | vs DET | 100 | W 6-2 | 39-61 | 7 | 24,037 | Dave LaPoint | Steve Searcy | Dave LaPoint | Steve Searcy | | 377 | 449 | -72 |
| 1990-07-31 | vs DET | 101 | W 10-4 | 40-61 | 7 | 21,682 | Mark Leiter | Dan Petry | Mark Leiter | Dan Petry | | 387 | 453 | -66 |
| 1990-08-01 | vs DET | 102 | L 4-15 | 40-62 | 7 | 22,288 | Andy Hawkins | Jack Morris | Jack Morris | Andy Hawkins | | 391 | 468 | -77 |
| 1990-08-02 | vs DET | 103 | L 5-6 | 40-63 | 7 | 20,160 | Jeff Robinson | Walt Terrell | Clay Parker | Alan Mills | Frank Tanana | 396 | 474 | -78 |
| 1990-08-03 | vs CLE | 104 | W 6-4 | 41-63 | 7 | 27,945 | Chuck Cary | Tom Candiotti | Lee Guetterman | Tom Candiotti | | 402 | 478 | -76 |
| 1990-08-04 | vs CLE | 105 | L 3-17 | 41-64 | 7 | 24,550 | Tim Leary | Buddy Black | Buddy Black | Tim Leary | | 405 | 495 | -90 |
| 1990-08-05 | vs CLE | 106 | W 5-3 | 42-64 | 7 | 34,488 | Dave LaPoint | Mike Walker | Greg Cadaret | Steve Olin | | 410 | 498 | -88 |
| 1990-08-06 | vs CLE | 107 | W 2-1 | 43-64 | 7 | 22,205 | Andy Hawkins | Greg Swindell | Andy Hawkins | Greg Swindell | Dave Righetti | 412 | 499 | -87 |
| 1990-08-07 | @ SEA | 108 | W 3-1 | 44-64 | 7 | 17,823 | Mike Witt | Erik Hanson | Mike Witt | Erik Hanson | Dave Righetti | 415 | 500 | -85 |
| 1990-08-08 | @ SEA | 109 | W 6-4 | 45-64 | 7 | 14,081 | Chuck Cary | Brian Holman | Eric Plunk | Keith Comstock | Dave Righetti | 421 | 504 | -83 |
| 1990-08-09 | @ SEA | 110 | W 1-0 | 46-64 | 7 | 15,329 | Tim Leary | Matt Young | Tim Leary | Matt Young | Lee Guetterman | 422 | 504 | -82 |
| 1990-08-10 | @ OAK | 111 | L 0-3 | 46-65 | 7 | 44,400 | Dave LaPoint | Dave Stewart | Dave Stewart | Dave LaPoint | Rick Honeycutt | 422 | 507 | -85 |
| 1990-08-11 | @ OAK | 112 | L 1-10 | 46-66 | 7 | 43,479 | Andy Hawkins | Curt Young | Curt Young | Andy Hawkins | Gene Nelson | 423 | 517 | -94 |
| 1990-08-12 | @ OAK | 113 | L 1-6 | 46-67 | 7 | 44,192 | Mike Witt | Bob Welch | Bob Welch | Mike Witt | Rick Honeycutt | 424 | 523 | -99 |
| 1990-08-13 | @ CAL | 114 | L 2-4 | 46-68 | 7 | 28,387 | Chuck Cary | Kirk McCaskill | Kirk McCaskill | Chuck Cary | Bryan Harvey | 426 | 527 | -101 |
| 1990-08-14 | @ CAL | 115 | L 5-9 | 46-69 | 7 | 27,937 | Tim Leary | Jim Abbott | Jim Abbott | Tim Leary | Willie Fraser | 431 | 536 | -105 |
| 1990-08-15 | @ CAL | 116 | L 1-8 | 46-70 | 7 | 29,845 | Dave LaPoint | Mark Langston | Mark Langston | Dave LaPoint | | 432 | 544 | -112 |
| 1990-08-17 | vs SEA | 117 | W 3-2 | 47-70 | 7 | 28,802 | Andy Hawkins | Bill Swift | Lee Guetterman | Bill Swift | Dave Righetti | 435 | 546 | -111 |
| 1990-08-18 | vs SEA | 118 | W 6-0 | 48-70 | 7 | 30,532 | Mike Witt | Brian Holman | Mike Witt | Brian Holman | | 441 | 546 | -105 |
| 1990-08-19 | vs SEA | 119 | W 3-1 | 49-70 | 7 | 35,056 | Tim Leary | Matt Young | Tim Leary | Matt Young | Dave Righetti | 444 | 547 | -103 |
| 1990-08-20 | vs TOR | 120 | W 6-5 | 50-70 | 7 | 21,661 | Dave LaPoint | Todd Stottlemyre | Greg Cadaret | Jim Acker | | 450 | 552 | -102 |
| 1990-08-21 | vs TOR | 121 | W 3-2 | 51-70 | 7 | 22,315 | Chuck Cary | John Candelaria | Chuck Cary | John Candelaria | Lee Guetterman | 453 | 554 | -101 |
| 1990-08-22 | vs TOR | 122 | W 4-2 | 52-70 | 7 | 25,088 | Andy Hawkins | John Cerutti | Andy Hawkins | John Cerutti | Dave Righetti | 457 | 556 | -99 |
| 1990-08-23 | vs MIL | 123 | L 2-8 | 52-71 | 7 | 18,729 | Mike Witt | Jaime Navarro | Jaime Navarro | Mike Witt | | 459 | 564 | -105 |
| 1990-08-24 | vs MIL | 124 | L 0-1 | 52-72 | 7 | 20,191 | Tim Leary | Mark Knudson | Mark Knudson | Tim Leary | Dan Plesac | 459 | 565 | -106 |
| 1990-08-25 | vs MIL | 125 | L 3-5 | 52-73 | 7 | 24,433 | Dave LaPoint | Tom Edens | Mark Lee | Dave Righetti | Chuck Crim | 462 | 570 | -108 |
| 1990-08-26 | vs MIL | 126 | W 4-3 | 53-73 | 7 | 31,045 | Chuck Cary | Ron Robinson | Lee Guetterman | Dan Plesac | | 466 | 573 | -107 |
| 1990-08-27 | @ BAL | 127 | W 4-0 | 54-73 | 7 | 24,589 | Andy Hawkins | Ben McDonald | Andy Hawkins | Ben McDonald | Dave Righetti | 470 | 573 | -103 |
| 1990-08-28 | @ BAL | 128 | W 11-3 | 55-73 | 7 | 23,900 | Mike Witt | Jose Mesa | Mike Witt | Jose Mesa | | 481 | 576 | -95 |
| 1990-08-29 | @ BAL | 129 | W 3-2 | 56-73 | 7 | 22,887 | Tim Leary | Anthony Telford | Tim Leary | Anthony Telford | Dave Righetti | 484 | 578 | -94 |
| 1990-08-30 | @ BAL | 130 | L 1-6 | 56-74 | 7 | 25,796 | Dave LaPoint | Pete Harnisch | Pete Harnisch | Dave LaPoint | | 485 | 584 | -99 |
| 1990-08-31 | @ BOS | 131 | L 3-7 | 56-75 | 7 | 34,464 | Chuck Cary | Greg Harris | Greg Harris | Chuck Cary | Jeff Gray | 488 | 591 | -103 |
| 1990-09-01 | @ BOS | 132 | L 1-15 | 56-76 | 7 | 34,482 | Andy Hawkins | Mike Boddicker | Mike Boddicker | Andy Hawkins | | 489 | 606 | -117 |
| 1990-09-02 | @ BOS | 133 | L 1-7 | 56-77 | 7 | 35,458 | Mike Witt | Tom Bolton | Tom Bolton | Mike Witt | | 490 | 613 | -123 |
| 1990-09-03 | vs CAL | 134 | L 0-7 | 56-78 | 7 | 27,013 | Tim Leary | Kirk McCaskill | Kirk McCaskill | Tim Leary | Willie Fraser | 490 | 620 | -130 |
| 1990-09-05 | vs CAL | 135 | W 2-1 | 57-78 | 7 | 23,010 | Dave LaPoint | Jim Abbott | Dave LaPoint | Bryan Harvey | Dave Righetti | 492 | 621 | -129 |
| 1990-09-06 | vs CAL | 136 | L 6-12 | 57-79 | 7 | 18,707 | Chuck Cary | Mark Langston | Bob McClure | Lee Guetterman | | 498 | 633 | -135 |
| 1990-09-07 | vs OAK | 137 | L 1-7 | 57-80 | 7 | 27,034 | Andy Hawkins | Curt Young | Curt Young | Andy Hawkins | Todd Burns | 499 | 640 | -141 |
| 1990-09-08 | vs OAK | 138 | L 2-5 | 57-81 | 7 | 35,721 | Mike Witt | Scott Sanderson | Scott Sanderson | Mike Witt | Dennis Eckersley | 501 | 645 | -144 |
| 1990-09-09 | vs OAK | 139 | L 3-7 | 57-82 | 7 | 36,391 | Tim Leary | Dave Stewart | Dave Stewart | Tim Leary | | 504 | 652 | -148 |
| 1990-09-10 | vs TEX | 140 | L 0-1 | 57-83 | 7 | 17,048 | Dave Eiland | Scott Chiamparino | Kenny Rogers | Lee Guetterman | Mike Jeffcoat | 504 | 653 | -149 |
| 1990-09-11 | vs TEX | 141 | W 5-4 | 58-83 | 7 | 19,413 | Chuck Cary | Bobby Witt | Lee Guetterman | Bobby Witt | Dave Righetti | 509 | 657 | -148 |
| 1990-09-12 | vs TEX | 142 | L 4-5 | 58-84 | 7 | 18,624 | Steve Adkins | Charlie Hough | Charlie Hough | Steve Adkins | Kenny Rogers | 513 | 662 | -149 |
| 1990-09-13 | @ DET | 143 | W 7-3 | 59-84 | 7 | 13,152 | Mike Witt | Walt Terrell | Mike Witt | Walt Terrell | | 520 | 665 | -145 |
| 1990-09-14 | @ DET | 144 | W 5-2 | 60-84 | 7 | 15,646 | Tim Leary | Scott Aldred | Tim Leary | Scott Aldred | Dave Righetti | 525 | 667 | -142 |
| 1990-09-15 | @ DET | 145 | L 3-4 | 60-85 | 7 | 18,976 | Dave Eiland | Frank Tanana | Frank Tanana | Dave Eiland | Ed Nunez | 528 | 671 | -143 |
| 1990-09-16 | @ DET | 146 | L 2-5 | 60-86 | 7 | 19,953 | Chuck Cary | Steve Searcy | Steve Searcy | Chuck Cary | Paul Gibson | 530 | 676 | -146 |
| 1990-09-17 | @ TOR | 147 | L 4-6 | 60-87 | 7 | 49,902 | Steve Adkins | Todd Stottlemyre | John Cerutti | Eric Plunk | Tom Henke | 534 | 682 | -148 |
| 1990-09-18 | @ TOR | 148 | L 2-3 | 60-88 | 7 | 49,887 | Mike Witt | Dave Stieb | Buddy Black | Lee Guetterman | | 536 | 685 | -149 |
| 1990-09-19 | @ TOR | 149 | L 6-7 | 60-89 | 7 | 49,890 | Tim Leary | Jimmy Key | Jimmy Key | Tim Leary | Tom Henke | 542 | 692 | -150 |
| 1990-09-20 | vs CLE | 150 | L 7-12 | 60-90 | 7 | 18,058 | Dave Eiland | Greg Swindell | Mike Walker | Rich Monteleone | | 549 | 704 | -155 |
| 1990-09-21 | vs BOS | 151 | L 0-3 | 60-91 | 7 | 27,573 | Chuck Cary | Dana Kiecker | Dana Kiecker | Chuck Cary | Larry Andersen | 549 | 707 | -158 |
| 1990-09-22 | vs BOS | 152 | W 5-2 | 61-91 | 7 | 37,795 | Steve Adkins | Mike Boddicker | Eric Plunk | Jeff Gray | Dave Righetti | 554 | 709 | -155 |
| 1990-09-23 | vs BOS | 153 | W 5-4 | 62-91 | 7 | 40,431 | Mike Witt | Tom Bolton | Mike Witt | Tom Bolton | Dave Righetti | 559 | 713 | -154 |
| 1990-09-24 | vs BAL | 154 | L 3-6 | 62-92 | 7 | 17,084 | Mark Leiter | Jose Mesa | Jose Bautista | Alan Mills | Gregg Olson | 562 | 719 | -157 |
| 1990-09-25 | vs BAL | 155 | W 15-3 | 63-92 | 7 | 17,548 | Dave Eiland | Anthony Telford | Dave Eiland | Anthony Telford | | 577 | 722 | -145 |
| 1990-09-26 | vs BAL | 156 | W 4-2 | 64-92 | 7 | 17,544 | Chuck Cary | Jeff Ballard | Chuck Cary | Jeff Ballard | Dave Righetti | 581 | 724 | -143 |
| 1990-09-28 | @ MIL | 157 | W 7-2 | 65-92 | 7 | 12,072 | Steve Adkins | Teddy Higuera | Steve Adkins | Teddy Higuera | | 588 | 726 | -138 |
| 1990-09-29 | @ MIL | 158 | L 1-8 | 65-93 | 7 | 16,531 | Mike Witt | Jaime Navarro | Jaime Navarro | Mike Witt | | 589 | 734 | -145 |
| 1990-09-30 | @ MIL | 159 | W 7-2 | 66-93 | 7 | 10,622 | Dave Eiland | Bill Krueger | Dave Eiland | Tom Edens | Greg Cadaret | 596 | 736 | -140 |
| 1990-10-01 | vs DET | 160 | L 0-2 | 66-94 | 7 | 12,125 | Chuck Cary | Frank Tanana | Frank Tanana | Chuck Cary | Jerry Gleaton | 596 | 738 | -142 |
| 1990-10-02 | vs DET | 161 | W 4-1 | 67-94 | 7 | 13,734 | Mark Leiter | Steve Searcy | Lee Guetterman | Ed Nunez | Dave Righetti | 600 | 739 | -139 |
| 1990-10-03 | vs DET | 162 | L 3-10 | 67-95 | 7 | 13,380 | Steve Adkins | Jack Morris | Jack Morris | Steve Adkins | | 603 | 749 | -146 |