| 1990-04-09 | @ OAK | 1 | L 3-8 | 0-1 | 6 | 48,219 | Allan Anderson | Dave Stewart | Dave Stewart | Allan Anderson | Rick Honeycutt | 3 | 8 | -5 |
| 1990-04-10 | @ OAK | 2 | L 3-5 | 0-2 | 7 | 19,757 | Roy Smith | Bob Welch | Bob Welch | Roy Smith | Dennis Eckersley | 6 | 13 | -7 |
| 1990-04-11 | @ OAK | 3 | W 3-0 | 1-2 | 6 | 27,775 | Kevin Tapani | Mike Moore | Kevin Tapani | Mike Moore | Rick Aguilera | 9 | 13 | -4 |
| 1990-04-12 | @ CAL | 4 | L 1-3 | 1-3 | 7 | 24,479 | David West | Kirk McCaskill | Kirk McCaskill | David West | Mark Eichhorn | 10 | 16 | -6 |
| 1990-04-13 | @ CAL | 5 | W 7-4 | 2-3 | 4 | 33,217 | Allan Anderson | Jim Abbott | Allan Anderson | Mike Witt | Rick Aguilera | 17 | 20 | -3 |
| 1990-04-14 | @ CAL | 6 | L 5-7 | 2-4 | 6 | 34,407 | Roy Smith | Bert Blyleven | Bryan Harvey | Rick Aguilera | | 22 | 27 | -5 |
| 1990-04-15 | @ CAL | 7 | L 1-4 | 2-5 | 6 | 27,302 | Kevin Tapani | Chuck Finley | Chuck Finley | Kevin Tapani | Bryan Harvey | 23 | 31 | -8 |
| 1990-04-16 | @ SEA | 8 | L 3-6 | 2-6 | 7 | 12,538 | David West | Randy Johnson | Randy Johnson | David West | Mike Schooler | 26 | 37 | -11 |
| 1990-04-17 | @ SEA | 9 | W 6-5 | 3-6 | 6 | 9,053 | Allan Anderson | Erik Hanson | Juan Berenguer | Keith Comstock | Rick Aguilera | 32 | 42 | -10 |
| 1990-04-18 | @ SEA | 10 | W 4-3 | 4-6 | 6 | 9,425 | Roy Smith | Matt Young | Terry Leach | Matt Young | Rick Aguilera | 36 | 45 | -9 |
| 1990-04-20 | vs CAL | 11 | W 13-1 | 5-6 | 4 | 37,975 | Kevin Tapani | Jim Abbott | Kevin Tapani | Jim Abbott | | 49 | 46 | 3 |
| 1990-04-21 | vs CAL | 12 | W 8-0 | 6-6 | 3 | 21,600 | David West | Bert Blyleven | David West | Bert Blyleven | John Candelaria | 57 | 46 | 11 |
| 1990-04-22 | vs CAL | 13 | L 2-5 | 6-7 | 5 | 20,875 | Allan Anderson | Chuck Finley | Chuck Finley | Allan Anderson | Mark Eichhorn | 59 | 51 | 8 |
| 1990-04-23 | vs DET | 14 | L 3-6 | 6-8 | 5 | 13,129 | Roy Smith | Frank Tanana | Frank Tanana | Roy Smith | Mike Henneman | 62 | 57 | 5 |
| 1990-04-24 | vs DET | 15 | W 16-4 | 7-8 | 4 | 13,561 | Mark Guthrie | Kevin Ritz | John Candelaria | Kevin Ritz | | 78 | 61 | 17 |
| 1990-04-25 | vs DET | 16 | L 4-6 | 7-9 | 5 | 14,865 | Kevin Tapani | Jeff Robinson | Jeff Robinson | Kevin Tapani | Mike Henneman | 82 | 67 | 15 |
| 1990-04-27 | @ CLE | 17 | L 2-7 | 7-10 | 5 | 12,753 | David West | Buddy Black | Buddy Black | David West | | 84 | 74 | 10 |
| 1990-04-28 | @ CLE | 18 | L 0-3 | 7-11 | 6 | 9,978 | Allan Anderson | John Farrell | John Farrell | Allan Anderson | Jesse Orosco | 84 | 77 | 7 |
| 1990-04-29 | @ CLE | 19 | L 4-6 | 7-12 | 6 | 14,956 | Roy Smith | Greg Swindell | Greg Swindell | Roy Smith | Doug Jones | 88 | 83 | 5 |
| 1990-05-01 | @ DET | 20 | W 9-5 | 8-12 | 5 | 10,563 | Kevin Tapani | Urbano Lugo | John Candelaria | Paul Gibson | | 97 | 88 | 9 |
| 1990-05-02 | @ DET | 21 | W 8-2 | 9-12 | 5 | 10,665 | David West | Jack Morris | David West | Jack Morris | | 105 | 90 | 15 |
| 1990-05-03 | @ DET | 22 | W 3-1 | 10-12 | 4 | 12,454 | Allan Anderson | Frank Tanana | Terry Leach | Mike Henneman | Rick Aguilera | 108 | 91 | 17 |
| 1990-05-05 | @ MIL | 23 | W 9-5 | 11-12 | 4 | 35,002 | Roy Smith | Chris Bosio | John Candelaria | Chuck Crim | | 117 | 96 | 21 |
| 1990-05-06 | @ MIL | 24 | W 4-0 | 12-12 | 4 | 27,314 | Kevin Tapani | Teddy Higuera | Kevin Tapani | Teddy Higuera | | 121 | 96 | 25 |
| 1990-05-08 | vs CLE | 25 | W 6-5 | 13-12 | 3 | 13,608 | David West | John Farrell | Juan Berenguer | Steve Olin | Rick Aguilera | 127 | 101 | 26 |
| 1990-05-09 | vs CLE | 26 | L 3-7 | 13-13 | 4 | 16,748 | John Candelaria | Sergio Valdez | Sergio Valdez | John Candelaria | Doug Jones | 130 | 108 | 22 |
| 1990-05-10 | vs CLE | 27 | W 3-2 | 14-13 | 3 | 13,439 | Roy Smith | Greg Swindell | Roy Smith | Greg Swindell | Rick Aguilera | 133 | 110 | 23 |
| 1990-05-11 | vs MIL | 28 | L 3-6 | 14-14 | 3 | 32,804 | Allan Anderson | Bill Wegman | Bill Wegman | Allan Anderson | Dan Plesac | 136 | 116 | 20 |
| 1990-05-12 | vs MIL | 29 | W 5-2 | 15-14 | 3 | 37,759 | Kevin Tapani | Mark Knudson | Kevin Tapani | Mark Knudson | Rick Aguilera | 141 | 118 | 23 |
| 1990-05-13 | vs MIL | 30 | W 8-6 | 16-14 | 3 | 24,123 | David West | Jaime Navarro | Juan Berenguer | Bill Krueger | Rick Aguilera | 149 | 124 | 25 |
| 1990-05-14 | vs OAK | 31 | W 6-2 | 17-14 | 3 | 18,966 | Allan Anderson | Dave Stewart | Allan Anderson | Dave Stewart | | 155 | 126 | 29 |
| 1990-05-15 | @ NYA | 32 | L 3-7 | 17-15 | 3 | 16,586 | Roy Smith | Chuck Cary | Chuck Cary | Roy Smith | | 158 | 133 | 25 |
| 1990-05-17 | @ NYA | 33 | W 4-1 | 18-15 | 3 | 16,267 | Kevin Tapani | Dave LaPoint | Kevin Tapani | Dave LaPoint | Rick Aguilera | 162 | 134 | 28 |
| 1990-05-18 | @ BOS | 34 | W 6-0 | 19-15 | 3 | 31,779 | Tim Drummond | Greg Harris | John Candelaria | Greg Harris | | 168 | 134 | 34 |
| 1990-05-19 | @ BOS | 35 | L 1-13 | 19-16 | 3 | 34,145 | Allan Anderson | Roger Clemens | Roger Clemens | Allan Anderson | | 169 | 147 | 22 |
| 1990-05-20 | @ BOS | 36 | W 5-4 | 20-16 | 3 | 33,141 | Roy Smith | Eric Hetzel | Roy Smith | Eric Hetzel | Rick Aguilera | 174 | 151 | 23 |
| 1990-05-21 | @ BAL | 37 | W 7-3 | 21-16 | 3 | 20,353 | David West | Bob Milacki | Mark Guthrie | Bob Milacki | | 181 | 154 | 27 |
| 1990-05-22 | @ BAL | 38 | L 2-10 | 21-17 | 3 | 18,892 | Kevin Tapani | Jeff Ballard | Mark Williamson | Kevin Tapani | | 183 | 164 | 19 |
| 1990-05-23 | vs NYA | 39 | L 0-12 | 21-18 | 3 | 17,195 | Tim Drummond | Tim Leary | Tim Leary | Tim Drummond | | 183 | 176 | 7 |
| 1990-05-24 | vs NYA | 40 | W 5-4 | 22-18 | 3 | 19,649 | Allan Anderson | Mike Witt | Rick Aguilera | Greg Cadaret | | 188 | 180 | 8 |
| 1990-05-25 | vs BOS | 41 | W 16-0 | 23-18 | 3 | 31,564 | Roy Smith | Eric Hetzel | Roy Smith | Eric Hetzel | | 204 | 180 | 24 |
| 1990-05-26 | vs BOS | 42 | W 6-5 | 24-18 | 3 | 32,048 | Mark Guthrie | Mike Boddicker | John Candelaria | Rob Murphy | Rick Aguilera | 210 | 185 | 25 |
| 1990-05-27 | vs BOS | 43 | W 3-1 | 25-18 | 3 | 28,173 | Kevin Tapani | Dana Kiecker | Kevin Tapani | Dana Kiecker | Rick Aguilera | 213 | 186 | 27 |
| 1990-05-28 | vs BAL | 44 | W 6-4 | 26-18 | 3 | 21,226 | David West | Dave Johnson | Juan Berenguer | Joe Price | John Candelaria | 219 | 190 | 29 |
| 1990-05-29 | vs BAL | 45 | L 1-5 | 26-19 | 3 | 15,225 | Allan Anderson | Bob Milacki | Bob Milacki | Allan Anderson | | 220 | 195 | 25 |
| 1990-05-30 | vs BAL | 46 | W 12-3 | 27-19 | 3 | 14,689 | Roy Smith | Pete Harnisch | Roy Smith | Pete Harnisch | | 232 | 198 | 34 |
| 1990-05-31 | @ CHA | 47 | W 3-2 | 28-19 | 3 | 13,124 | Mark Guthrie | Jerry Kutzler | Mark Guthrie | Jerry Kutzler | Rick Aguilera | 235 | 200 | 35 |
| 1990-06-01 | @ CHA | 48 | L 1-2 | 28-20 | 3 | 17,552 | Kevin Tapani | Melido Perez | Barry Jones | Terry Leach | | 236 | 202 | 34 |
| 1990-06-02 | @ CHA | 49 | W 2-1 | 29-20 | 3 | 30,153 | David West | Eric King | John Candelaria | Eric King | Rick Aguilera | 238 | 203 | 35 |
| 1990-06-03 | @ CHA | 50 | L 2-5 | 29-21 | 3 | 15,952 | Allan Anderson | Jack McDowell | Jack McDowell | Allan Anderson | Bobby Thigpen | 240 | 208 | 32 |
| 1990-06-05 | @ TOR | 51 | L 3-7 | 29-22 | 3 | 49,741 | Roy Smith | David Wells | David Wells | Roy Smith | | 243 | 215 | 28 |
| 1990-06-06 | @ TOR | 52 | W 12-5 | 30-22 | 3 | 49,652 | Mark Guthrie | Willie Blair | John Candelaria | Willie Blair | | 255 | 220 | 35 |
| 1990-06-07 | @ TOR | 53 | L 3-10 | 30-23 | 3 | 49,845 | Kevin Tapani | Todd Stottlemyre | Todd Stottlemyre | Kevin Tapani | | 258 | 230 | 28 |
| 1990-06-08 | vs CHA | 54 | L 2-3 | 30-24 | 3 | 25,205 | David West | Jack McDowell | Scott Radinsky | Juan Berenguer | Bobby Thigpen | 260 | 233 | 27 |
| 1990-06-09 | vs CHA | 55 | L 2-4 | 30-25 | 3 | 27,991 | Allan Anderson | Eric King | Eric King | Allan Anderson | Bobby Thigpen | 262 | 237 | 25 |
| 1990-06-10 | vs CHA | 56 | L 3-5 | 30-26 | 3 | 21,268 | Roy Smith | Greg Hibbard | Greg Hibbard | Roy Smith | Bobby Thigpen | 265 | 242 | 23 |
| 1990-06-12 | vs TOR | 57 | L 4-5 | 30-27 | 3 | 18,298 | Kevin Tapani | Todd Stottlemyre | Todd Stottlemyre | John Candelaria | Duane Ward | 269 | 247 | 22 |
| 1990-06-13 | vs TOR | 58 | L 1-10 | 30-28 | 3 | 17,086 | David West | John Cerutti | John Cerutti | David West | Tom Henke | 270 | 257 | 13 |
| 1990-06-14 | vs TOR | 59 | L 1-7 | 30-29 | 3 | 18,679 | Allan Anderson | Dave Stieb | Dave Stieb | Allan Anderson | | 271 | 264 | 7 |
| 1990-06-15 | @ KCA | 60 | L 1-5 | 30-30 | 3 | 29,786 | Tim Drummond | Kevin Appier | Kevin Appier | Tim Drummond | | 272 | 269 | 3 |
| 1990-06-16 | @ KCA | 61 | L 3-5 | 30-31 | 4 | 38,006 | Mark Guthrie | Tom Gordon | Tom Gordon | Mark Guthrie | | 275 | 274 | 1 |
| 1990-06-17 | @ KCA | 62 | W 4-1 | 31-31 | 3 | 28,370 | Kevin Tapani | Bret Saberhagen | Kevin Tapani | Bret Saberhagen | Rick Aguilera | 279 | 275 | 4 |
| 1990-06-18 | @ TEX | 63 | L 1-7 | 31-32 | 4 | 26,766 | David West | Charlie Hough | Charlie Hough | David West | | 280 | 282 | -2 |
| 1990-06-19 | @ TEX | 64 | L 4-5 | 31-33 | 4 | 19,068 | Allan Anderson | Mike Jeffcoat | Brad Arnsberg | John Candelaria | Kenny Rogers | 284 | 287 | -3 |
| 1990-06-20 | @ TEX | 65 | L 0-8 | 31-34 | 5 | 37,821 | Tim Drummond | Kevin Brown | Kevin Brown | Tim Drummond | | 284 | 295 | -11 |
| 1990-06-21 | vs KCA | 66 | L 4-14 | 31-35 | 5 | 22,489 | Mark Guthrie | Tom Gordon | Tom Gordon | Mark Guthrie | Andy McGaffigan | 288 | 309 | -21 |
| 1990-06-22 | vs KCA | 67 | W 3-2 | 32-35 | 4 | 21,033 | Kevin Tapani | Bret Saberhagen | Kevin Tapani | Bret Saberhagen | Rick Aguilera | 291 | 311 | -20 |
| 1990-06-23 | vs KCA | 68 | W 5-1 | 33-35 | 4 | 26,795 | David West | Mark Gubicza | David West | Mark Gubicza | Jack Savage | 296 | 312 | -16 |
| 1990-06-24 | vs KCA | 69 | L 2-11 | 33-36 | 5 | 39,566 | Allan Anderson | Storm Davis | Storm Davis | Allan Anderson | | 298 | 323 | -25 |
| 1990-06-25 | vs TEX | 70 | W 9-1 | 34-36 | 5 | 13,687 | Scott Erickson | Mike Jeffcoat | Scott Erickson | Mike Jeffcoat | John Candelaria | 307 | 324 | -17 |
| 1990-06-26 | vs TEX | 71 | W 5-4 | 35-36 | 4 | 15,934 | Roy Smith | Kevin Brown | Juan Berenguer | Kevin Brown | Rick Aguilera | 312 | 328 | -16 |
| 1990-06-27 | vs TEX | 72 | L 2-9 | 35-37 | 5 | 28,495 | Kevin Tapani | Nolan Ryan | Nolan Ryan | Kevin Tapani | | 314 | 337 | -23 |
| 1990-06-28 | vs TEX | 73 | L 6-8 | 35-38 | 5 | 25,666 | David West | Bobby Witt | Bobby Witt | David West | | 320 | 345 | -25 |
| 1990-06-29 | vs BAL | 74 | L 2-6 | 35-39 | 5 | 20,110 | Allan Anderson | Dave Johnson | Dave Johnson | Allan Anderson | Curt Schilling | 322 | 351 | -29 |
| 1990-06-30 | vs BAL | 75 | L 0-6 | 35-40 | 5 | 21,080 | Scott Erickson | Bob Milacki | Bob Milacki | Scott Erickson | | 322 | 357 | -35 |
| 1990-07-01 | vs BAL | 76 | W 4-3 | 36-40 | 5 | 31,785 | Roy Smith | Pete Harnisch | Rick Aguilera | Gregg Olson | | 326 | 360 | -34 |
| 1990-07-03 | vs BOS | 77 | W 7-3 | 37-40 | 5 | 20,521 | Kevin Tapani | Roger Clemens | Kevin Tapani | Roger Clemens | Rick Aguilera | 333 | 363 | -30 |
| 1990-07-04 | vs BOS | 78 | L 3-4 | 37-41 | 5 | 23,604 | David West | Greg Harris | Dennis Lamp | Rick Aguilera | Jeff Reardon | 336 | 367 | -31 |
| 1990-07-05 | vs BOS | 79 | W 7-4 | 38-41 | 5 | 18,473 | Scott Erickson | Dana Kiecker | Tim Drummond | Rob Murphy | Rick Aguilera | 343 | 371 | -28 |
| 1990-07-06 | @ NYA | 80 | W 2-0 | 39-42 | 5 | 0 | Allan Anderson | Andy Hawkins | Juan Berenguer | Andy Hawkins | Rick Aguilera | 345 | 371 | -26 |
| 1990-07-06 | @ NYA | 81 | L 3-5 | 39-42 | 5 | 25,120 | Roy Smith | Dave LaPoint | Dave LaPoint | Roy Smith | Dave Righetti | 348 | 376 | -28 |
| 1990-07-07 | @ NYA | 82 | L 4-5 | 39-43 | 5 | 30,201 | Kevin Tapani | Jimmy Jones | Lee Guetterman | Terry Leach | | 352 | 381 | -29 |
| 1990-07-08 | @ NYA | 83 | W 6-3 | 40-43 | 5 | 38,119 | David West | Tim Leary | David West | Tim Leary | Tim Drummond | 358 | 384 | -26 |
| 1990-07-11 | vs OAK | 84 | L 7-11 | 40-44 | 5 | 20,948 | Allan Anderson | Scott Sanderson | Scott Sanderson | Allan Anderson | Dennis Eckersley | 365 | 395 | -30 |
| 1990-07-13 | @ BAL | 85 | L 5-8 | 41-45 | 6 | 0 | Kevin Tapani | Pete Harnisch | Mark Williamson | Juan Berenguer | Gregg Olson | 370 | 403 | -33 |
| 1990-07-13 | @ BAL | 86 | W 3-1 | 41-45 | 6 | 32,915 | David West | Dave Johnson | David West | Dave Johnson | Terry Leach | 373 | 404 | -31 |
| 1990-07-14 | @ BAL | 87 | L 2-3 | 41-46 | 6 | 33,128 | Roy Smith | John Mitchell | Mark Williamson | Terry Leach | | 375 | 407 | -32 |
| 1990-07-15 | @ BAL | 88 | W 10-3 | 42-46 | 6 | 42,817 | Allan Anderson | Bob Milacki | Allan Anderson | Bob Milacki | | 385 | 410 | -25 |
| 1990-07-16 | @ BOS | 89 | W 3-2 | 43-46 | 5 | 33,445 | Mark Guthrie | Wes Gardner | Juan Berenguer | Jeff Gray | Rick Aguilera | 388 | 412 | -24 |
| 1990-07-17 | @ BOS | 90 | L 0-1 | 43-47 | 5 | 34,113 | Scott Erickson | Tom Bolton | Tom Bolton | Scott Erickson | Jeff Reardon | 388 | 413 | -25 |
| 1990-07-18 | @ BOS | 91 | L 4-5 | 43-48 | 6 | 34,838 | David West | Mike Boddicker | Dennis Lamp | Juan Berenguer | Jeff Reardon | 392 | 418 | -26 |
| 1990-07-19 | vs NYA | 92 | L 1-2 | 43-49 | 6 | 29,988 | Roy Smith | Tim Leary | Tim Leary | Roy Smith | Dave Righetti | 393 | 420 | -27 |
| 1990-07-20 | vs NYA | 93 | W 2-1 | 44-49 | 6 | 25,146 | Allan Anderson | Dave LaPoint | Allan Anderson | Dave LaPoint | | 395 | 421 | -26 |
| 1990-07-21 | vs NYA | 94 | W 2-1 | 45-49 | 6 | 27,108 | Mark Guthrie | Jeff Robinson | Mark Guthrie | Jeff Robinson | Rick Aguilera | 397 | 422 | -25 |
| 1990-07-22 | vs NYA | 95 | L 6-10 | 45-50 | 6 | 29,238 | Scott Erickson | Andy Hawkins | Greg Cadaret | Rick Aguilera | | 403 | 432 | -29 |
| 1990-07-24 | vs SEA | 96 | L 2-8 | 45-51 | 6 | 17,380 | David West | Matt Young | Matt Young | David West | | 405 | 440 | -35 |
| 1990-07-25 | vs SEA | 97 | W 6-0 | 46-51 | 6 | 21,384 | Kevin Tapani | Randy Johnson | Kevin Tapani | Randy Johnson | John Candelaria | 411 | 440 | -29 |
| 1990-07-26 | vs SEA | 98 | L 4-6 | 46-52 | 6 | 29,455 | Allan Anderson | Bill Swift | Bill Swift | Allan Anderson | Mike Schooler | 415 | 446 | -31 |
| 1990-07-27 | vs OAK | 99 | W 9-4 | 47-52 | 6 | 30,744 | Roy Smith | Mike Moore | Roy Smith | Mike Moore | | 424 | 450 | -26 |
| 1990-07-28 | vs OAK | 100 | L 1-4 | 48-53 | 5 | 0 | Mark Guthrie | Dave Stewart | Dave Stewart | Mark Guthrie | | 425 | 454 | -29 |
| 1990-07-28 | vs OAK | 101 | W 9-4 | 48-53 | 5 | 51,017 | Scott Erickson | Bob Welch | Scott Erickson | Bob Welch | | 434 | 458 | -24 |
| 1990-07-29 | vs OAK | 102 | W 6-5 | 49-53 | 5 | 33,588 | David West | Curt Young | Rick Aguilera | Rick Honeycutt | | 440 | 463 | -23 |
| 1990-07-30 | vs CAL | 103 | W 7-3 | 50-53 | 5 | 19,608 | Kevin Tapani | Bert Blyleven | Kevin Tapani | Bert Blyleven | Terry Leach | 447 | 466 | -19 |
| 1990-07-31 | vs CAL | 104 | L 2-13 | 50-54 | 5 | 20,607 | Allan Anderson | Chuck Finley | Chuck Finley | Allan Anderson | | 449 | 479 | -30 |
| 1990-08-01 | vs CAL | 105 | L 5-11 | 50-55 | 6 | 21,260 | Roy Smith | Mark Langston | Mark Langston | Roy Smith | Bryan Harvey | 454 | 490 | -36 |
| 1990-08-02 | @ SEA | 106 | L 2-7 | 50-56 | 6 | 14,004 | Mark Guthrie | Brian Holman | Brian Holman | Mark Guthrie | | 456 | 497 | -41 |
| 1990-08-03 | @ SEA | 107 | W 6-2 | 51-56 | 5 | 13,818 | Scott Erickson | Matt Young | Rick Aguilera | Mike Schooler | | 462 | 499 | -37 |
| 1990-08-04 | @ SEA | 108 | L 3-4 | 51-57 | 6 | 20,508 | Kevin Tapani | Randy Johnson | Michael Jackson | Jack Savage | | 465 | 503 | -38 |
| 1990-08-05 | @ SEA | 109 | L 0-4 | 51-58 | 6 | 17,248 | Allan Anderson | Bill Swift | Gene Harris | Allan Anderson | Keith Comstock | 465 | 507 | -42 |
| 1990-08-06 | vs MIL | 110 | L 0-6 | 51-59 | 7 | 27,583 | Roy Smith | Ron Robinson | Ron Robinson | Roy Smith | | 465 | 513 | -48 |
| 1990-08-07 | vs MIL | 111 | L 3-5 | 51-60 | 7 | 23,426 | Mark Guthrie | Jaime Navarro | Jaime Navarro | Mark Guthrie | Tom Edens | 468 | 518 | -50 |
| 1990-08-08 | vs MIL | 112 | W 4-2 | 52-60 | 7 | 23,748 | Scott Erickson | Mark Knudson | Scott Erickson | Mark Knudson | Rick Aguilera | 472 | 520 | -48 |
| 1990-08-10 | @ TOR | 113 | W 7-3 | 53-60 | 7 | 49,888 | David West | John Cerutti | David West | John Cerutti | | 479 | 523 | -44 |
| 1990-08-11 | @ TOR | 114 | L 4-7 | 53-61 | 7 | 49,873 | Roy Smith | Dave Stieb | Dave Stieb | Terry Leach | Tom Henke | 483 | 530 | -47 |
| 1990-08-12 | @ TOR | 115 | W 5-4 | 54-61 | 7 | 49,892 | Allan Anderson | Jimmy Key | Allan Anderson | Jimmy Key | | 488 | 534 | -46 |
| 1990-08-14 | @ CLE | 116 | W 5-4 | 55-61 | 7 | 11,270 | Mark Guthrie | Buddy Black | Mark Guthrie | Buddy Black | Rick Aguilera | 493 | 538 | -45 |
| 1990-08-15 | @ CLE | 117 | L 4-5 | 55-62 | 7 | 10,917 | David West | Mike Walker | Jesse Orosco | Tim Drummond | Doug Jones | 497 | 543 | -46 |
| 1990-08-16 | @ CLE | 118 | L 5-7 | 55-63 | 7 | 11,085 | Kevin Tapani | Greg Swindell | Greg Swindell | Kevin Tapani | Doug Jones | 502 | 550 | -48 |
| 1990-08-17 | vs TOR | 119 | L 1-5 | 55-64 | 7 | 28,173 | Scott Erickson | Dave Stieb | Dave Stieb | Scott Erickson | Duane Ward | 503 | 555 | -52 |
| 1990-08-18 | vs TOR | 120 | L 0-3 | 55-65 | 7 | 32,605 | Allan Anderson | Jimmy Key | Jimmy Key | Allan Anderson | Tom Henke | 503 | 558 | -55 |
| 1990-08-19 | vs TOR | 121 | L 1-9 | 55-66 | 7 | 29,004 | Mark Guthrie | David Wells | David Wells | Mark Guthrie | | 504 | 567 | -63 |
| 1990-08-20 | @ KCA | 122 | L 1-7 | 55-67 | 7 | 31,368 | David West | Storm Davis | Storm Davis | David West | | 505 | 574 | -69 |
| 1990-08-21 | @ KCA | 123 | L 7-8 | 55-68 | 7 | 22,751 | Paul Abbott | Jim Campbell | Steve Crawford | Paul Abbott | Jeff Montgomery | 512 | 582 | -70 |
| 1990-08-22 | @ KCA | 124 | L 2-6 | 55-69 | 7 | 24,483 | Scott Erickson | Tom Gordon | Tom Gordon | Scott Erickson | | 514 | 588 | -74 |
| 1990-08-24 | @ TEX | 125 | L 0-2 | 55-70 | 7 | 22,301 | Mark Guthrie | Craig McMurtry | John Barfield | Mark Guthrie | Brad Arnsberg | 514 | 590 | -76 |
| 1990-08-25 | @ TEX | 126 | W 8-5 | 56-70 | 7 | 27,073 | David West | Jamie Moyer | David West | Gary Mielke | Rick Aguilera | 522 | 595 | -73 |
| 1990-08-26 | @ TEX | 127 | L 0-1 | 56-71 | 7 | 17,691 | Paul Abbott | Bobby Witt | Bobby Witt | Terry Leach | | 522 | 596 | -74 |
| 1990-08-27 | vs CHA | 128 | W 7-0 | 57-71 | 7 | 15,329 | Allan Anderson | Melido Perez | Allan Anderson | Melido Perez | | 529 | 596 | -67 |
| 1990-08-28 | vs CHA | 129 | W 12-6 | 58-71 | 7 | 19,899 | Scott Erickson | Alex Fernandez | Tim Drummond | Adam Peterson | Gary Wayne | 541 | 602 | -61 |
| 1990-08-29 | vs CHA | 130 | W 6-1 | 59-71 | 7 | 18,159 | Mark Guthrie | Wayne Edwards | Mark Guthrie | Wayne Edwards | | 547 | 603 | -56 |
| 1990-08-30 | vs CHA | 131 | L 3-4 | 59-72 | 7 | 15,771 | David West | Jack McDowell | Jack McDowell | David West | Bobby Thigpen | 550 | 607 | -57 |
| 1990-08-31 | vs DET | 132 | L 6-12 | 59-73 | 7 | 21,071 | Paul Abbott | Jeff Robinson | Clay Parker | Paul Abbott | | 556 | 619 | -63 |
| 1990-09-01 | vs DET | 133 | L 5-9 | 59-74 | 7 | 17,370 | Allan Anderson | Randy Nosek | Randy Nosek | Allan Anderson | Mike Henneman | 561 | 628 | -67 |
| 1990-09-02 | vs DET | 134 | W 4-3 | 60-74 | 7 | 21,894 | Scott Erickson | Jack Morris | Scott Erickson | Jack Morris | Rick Aguilera | 565 | 631 | -66 |
| 1990-09-03 | @ MIL | 135 | W 6-0 | 62-74 | 7 | 0 | Mark Guthrie | Mark Knudson | Mark Guthrie | Mark Knudson | | 571 | 631 | -60 |
| 1990-09-03 | @ MIL | 136 | W 9-5 | 62-74 | 7 | 17,110 | Paul Abbott | Bill Krueger | Rick Aguilera | Dan Plesac | | 580 | 636 | -56 |
| 1990-09-04 | @ MIL | 137 | W 7-1 | 63-74 | 7 | 8,747 | David West | Tom Edens | Tim Drummond | Tom Edens | | 587 | 637 | -50 |
| 1990-09-05 | @ MIL | 138 | L 4-7 | 63-75 | 7 | 10,232 | Roy Smith | Ron Robinson | Ron Robinson | Gary Wayne | | 591 | 644 | -53 |
| 1990-09-07 | vs CLE | 139 | W 2-0 | 64-75 | 7 | 18,696 | Allan Anderson | Buddy Black | Allan Anderson | Buddy Black | Rick Aguilera | 593 | 644 | -51 |
| 1990-09-08 | vs CLE | 140 | W 6-1 | 65-75 | 7 | 17,394 | Scott Erickson | Mike Walker | Scott Erickson | Mike Walker | | 599 | 645 | -46 |
| 1990-09-09 | vs CLE | 141 | L 9-12 | 65-76 | 7 | 14,414 | Mark Guthrie | Sergio Valdez | Steve Olin | Jack Savage | | 608 | 657 | -49 |
| 1990-09-10 | @ CAL | 142 | L 1-3 | 65-77 | 7 | 21,379 | Paul Abbott | Jim Abbott | Jim Abbott | Paul Abbott | Bryan Harvey | 609 | 660 | -51 |
| 1990-09-11 | @ CAL | 143 | L 0-9 | 65-78 | 7 | 21,908 | Kevin Tapani | Mark Langston | Mark Langston | Kevin Tapani | | 609 | 669 | -60 |
| 1990-09-12 | @ CAL | 144 | L 6-8 | 65-79 | 7 | 21,480 | Larry Casian | Joe Grahe | Joe Grahe | Tim Drummond | Bryan Harvey | 615 | 677 | -62 |
| 1990-09-13 | @ OAK | 145 | W 3-1 | 66-79 | 7 | 26,622 | Scott Erickson | Todd Burns | Juan Berenguer | Gene Nelson | | 618 | 678 | -60 |
| 1990-09-14 | @ OAK | 146 | L 1-9 | 66-80 | 7 | 34,091 | Mark Guthrie | Dave Stewart | Dave Stewart | Mark Guthrie | | 619 | 687 | -68 |
| 1990-09-15 | @ OAK | 147 | L 1-4 | 66-81 | 7 | 43,151 | Paul Abbott | Bob Welch | Bob Welch | Paul Abbott | Dennis Eckersley | 620 | 691 | -71 |
| 1990-09-16 | @ OAK | 148 | L 4-5 | 66-82 | 7 | 38,043 | Kevin Tapani | Curt Young | Dennis Eckersley | Juan Berenguer | | 624 | 696 | -72 |
| 1990-09-17 | vs KCA | 149 | L 0-1 | 66-83 | 7 | 10,818 | Larry Casian | Steve Farr | Steve Farr | Larry Casian | Jeff Montgomery | 624 | 697 | -73 |
| 1990-09-18 | vs KCA | 150 | W 10-4 | 67-83 | 7 | 11,621 | Scott Erickson | Tom Gordon | Scott Erickson | Tom Gordon | | 634 | 701 | -67 |
| 1990-09-19 | vs KCA | 151 | W 1-0 | 68-83 | 7 | 10,690 | Mark Guthrie | Kevin Appier | Gary Wayne | Jeff Montgomery | | 635 | 701 | -66 |
| 1990-09-21 | vs TEX | 152 | L 1-2 | 68-84 | 7 | 13,400 | Kevin Tapani | Bobby Witt | Bobby Witt | Juan Berenguer | | 636 | 703 | -67 |
| 1990-09-22 | vs TEX | 153 | W 2-0 | 69-84 | 7 | 26,977 | Allan Anderson | Scott Chiamparino | Larry Casian | Scott Chiamparino | Rich Garces | 638 | 703 | -65 |
| 1990-09-23 | vs TEX | 154 | W 6-4 | 70-84 | 7 | 12,730 | Scott Erickson | Charlie Hough | Scott Erickson | Charlie Hough | Rick Aguilera | 644 | 707 | -63 |
| 1990-09-25 | @ CHA | 155 | W 4-3 | 71-84 | 7 | 24,455 | Mark Guthrie | Jack McDowell | Mark Guthrie | Jack McDowell | Rick Aguilera | 648 | 710 | -62 |
| 1990-09-26 | @ CHA | 156 | L 1-3 | 71-85 | 7 | 25,617 | Kevin Tapani | Greg Hibbard | Greg Hibbard | Kevin Tapani | Bobby Thigpen | 649 | 713 | -64 |
| 1990-09-28 | @ DET | 157 | L 1-3 | 71-86 | 7 | 18,321 | Allan Anderson | Jack Morris | Jack Morris | Allan Anderson | Mike Henneman | 650 | 716 | -66 |
| 1990-09-29 | @ DET | 158 | W 2-0 | 72-86 | 7 | 19,727 | Scott Erickson | Scott Aldred | Scott Erickson | Scott Aldred | Rick Aguilera | 652 | 716 | -64 |
| 1990-09-30 | @ DET | 159 | L 0-1 | 72-87 | 7 | 19,487 | Mark Guthrie | Walt Terrell | Walt Terrell | Mark Guthrie | Jerry Gleaton | 652 | 717 | -65 |
| 1990-10-01 | vs SEA | 160 | W 7-5 | 73-87 | 7 | 9,202 | Kevin Tapani | Russ Swan | Kevin Tapani | Russ Swan | Rich Garces | 659 | 722 | -63 |
| 1990-10-02 | vs SEA | 161 | L 0-3 | 73-88 | 7 | 10,091 | Paul Abbott | Erik Hanson | Erik Hanson | Paul Abbott | | 659 | 725 | -66 |
| 1990-10-03 | vs SEA | 162 | W 7-4 | 74-88 | 7 | 9,826 | Larry Casian | Randy Johnson | Larry Casian | Randy Johnson | Rick Aguilera | 666 | 729 | -63 |