| 1989-04-03 | vs MIL | 1 | W 2-1 | 1-0 | 2 | 40,618 | Greg Swindell | Don August | Greg Swindell | Don August | Doug Jones | 2 | 1 | 1 |
| 1989-04-06 | vs MIL | 2 | L 0-3 | 1-1 | 2 | 4,905 | Buddy Black | Chris Bosio | Chris Bosio | Buddy Black | | 2 | 4 | -2 |
| 1989-04-07 | @ NYA | 3 | W 4-2 | 2-1 | 2 | 55,655 | Rich Yett | John Candelaria | Rich Yett | John Candelaria | Doug Jones | 6 | 6 | 0 |
| 1989-04-08 | @ NYA | 4 | W 11-1 | 3-1 | 1 | 20,369 | Greg Swindell | Al Leiter | Greg Swindell | Al Leiter | | 17 | 7 | 10 |
| 1989-04-09 | @ NYA | 5 | W 4-3 | 4-1 | 1 | 25,328 | Tom Candiotti | Tommy John | Tom Candiotti | Tommy John | Doug Jones | 21 | 10 | 11 |
| 1989-04-10 | @ BOS | 6 | L 2-5 | 4-2 | 1 | 32,909 | Joe Skalski | Mike Boddicker | Mike Boddicker | Joe Skalski | Mike Smithson | 23 | 15 | 8 |
| 1989-04-12 | @ BOS | 7 | W 10-6 | 5-2 | 1 | 19,210 | Buddy Black | Oil Can Boyd | Buddy Black | Oil Can Boyd | Keith Atherton | 33 | 21 | 12 |
| 1989-04-13 | @ BOS | 8 | L 1-9 | 5-3 | 1 | 18,518 | Rich Yett | Roger Clemens | Roger Clemens | Rich Yett | | 34 | 30 | 4 |
| 1989-04-14 | @ MIL | 9 | L 4-8 | 5-4 | 1 | 9,533 | Greg Swindell | Mike Birkbeck | Mark Knudson | Joe Skalski | Dan Plesac | 38 | 38 | 0 |
| 1989-04-15 | @ MIL | 10 | L 1-5 | 5-5 | 2 | 19,043 | Tom Candiotti | Chris Bosio | Chris Bosio | Tom Candiotti | Chuck Crim | 39 | 43 | -4 |
| 1989-04-16 | @ MIL | 11 | L 3-4 | 5-6 | 4 | 18,547 | John Farrell | Bryan Clutterbuck | Chuck Crim | Keith Atherton | | 42 | 47 | -5 |
| 1989-04-19 | vs BOS | 12 | L 4-8 | 5-7 | 5 | 6,182 | Buddy Black | Roger Clemens | Roger Clemens | Buddy Black | | 46 | 55 | -9 |
| 1989-04-20 | vs BOS | 13 | L 2-5 | 5-8 | 6 | 7,236 | Rich Yett | Oil Can Boyd | Oil Can Boyd | Rich Yett | Lee Smith | 48 | 60 | -12 |
| 1989-04-21 | vs NYA | 14 | W 6-5 | 6-8 | 5 | 14,793 | Greg Swindell | Al Leiter | Doug Jones | Dale Mohorcic | | 54 | 65 | -11 |
| 1989-04-22 | vs NYA | 15 | W 3-1 | 7-8 | 4 | 16,607 | Tom Candiotti | Tommy John | Scott Bailes | Tommy John | | 57 | 66 | -9 |
| 1989-04-23 | vs NYA | 16 | L 0-5 | 7-9 | 4 | 22,128 | John Farrell | Andy Hawkins | Andy Hawkins | John Farrell | | 57 | 71 | -14 |
| 1989-04-24 | vs NYA | 17 | L 3-6 | 7-10 | 6 | 13,720 | Buddy Black | Dave LaPoint | Dave LaPoint | Buddy Black | Dave Righetti | 60 | 77 | -17 |
| 1989-04-25 | vs TEX | 18 | L 7-11 | 7-11 | 7 | 6,585 | Rich Yett | Bobby Witt | Bobby Witt | Scott Bailes | Brad Arnsberg | 67 | 88 | -21 |
| 1989-04-26 | vs TEX | 19 | L 2-3 | 7-12 | 7 | 5,457 | Greg Swindell | Jamie Moyer | Jeff Russell | Doug Jones | | 69 | 91 | -22 |
| 1989-04-28 | @ MIN | 20 | W 9-7 | 8-12 | 5 | 30,972 | Tom Candiotti | Shane Rawley | Tom Candiotti | Shane Rawley | Doug Jones | 78 | 98 | -20 |
| 1989-04-29 | @ MIN | 21 | W 4-1 | 9-12 | 5 | 49,653 | John Farrell | Frank Viola | John Farrell | Frank Viola | Doug Jones | 82 | 99 | -17 |
| 1989-04-30 | @ MIN | 22 | L 1-2 | 9-13 | 5 | 26,644 | Buddy Black | Roy Smith | Roy Smith | Buddy Black | Jeff Reardon | 83 | 101 | -18 |
| 1989-05-01 | @ TEX | 23 | W 11-1 | 10-13 | 4 | 30,192 | Rich Yett | Bobby Witt | Rich Yett | Bobby Witt | Keith Atherton | 94 | 102 | -8 |
| 1989-05-02 | @ TEX | 24 | W 8-3 | 11-13 | 4 | 12,772 | Greg Swindell | Jamie Moyer | Greg Swindell | Jamie Moyer | | 102 | 105 | -3 |
| 1989-05-03 | vs KCA | 25 | W 6-2 | 12-13 | 3 | 8,090 | Tom Candiotti | Charlie Leibrandt | Tom Candiotti | Charlie Leibrandt | | 108 | 107 | 1 |
| 1989-05-04 | vs KCA | 26 | W 3-1 | 13-13 | 3 | 6,757 | John Farrell | Bret Saberhagen | John Farrell | Bret Saberhagen | Doug Jones | 111 | 108 | 3 |
| 1989-05-05 | vs MIN | 27 | L 2-3 | 13-14 | 4 | 7,889 | Buddy Black | Roy Smith | German Gonzalez | Doug Jones | | 113 | 111 | 2 |
| 1989-05-07 | vs MIN | 28 | W 5-4 | 15-14 | 2 | 0 | Greg Swindell | Allan Anderson | Doug Jones | Francisco Oliveras | | 118 | 115 | 3 |
| 1989-05-07 | vs MIN | 29 | W 12-1 | 15-14 | 2 | 11,357 | Rich Yett | Freddie Toliver | Rich Yett | Freddie Toliver | | 130 | 116 | 14 |
| 1989-05-09 | @ KCA | 30 | L 1-3 | 15-15 | 2 | 22,634 | Tom Candiotti | Bret Saberhagen | Bret Saberhagen | Tom Candiotti | | 131 | 119 | 12 |
| 1989-05-10 | @ KCA | 31 | L 2-3 | 15-16 | 3 | 25,983 | John Farrell | Floyd Bannister | Jeff Montgomery | John Farrell | Steve Farr | 133 | 122 | 11 |
| 1989-05-12 | vs DET | 32 | L 3-6 | 15-17 | 4 | 19,866 | Buddy Black | Jack Morris | Jack Morris | Buddy Black | | 136 | 128 | 8 |
| 1989-05-13 | vs DET | 33 | W 3-1 | 16-17 | 3 | 16,272 | Greg Swindell | Doyle Alexander | Greg Swindell | Doyle Alexander | | 139 | 129 | 10 |
| 1989-05-14 | vs DET | 34 | W 8-3 | 17-17 | 2 | 13,906 | Tom Candiotti | Paul Gibson | Tom Candiotti | Paul Gibson | | 147 | 132 | 15 |
| 1989-05-15 | @ TOR | 35 | L 3-5 | 17-18 | 2 | 22,330 | John Farrell | Jimmy Key | Jimmy Key | John Farrell | | 150 | 137 | 13 |
| 1989-05-16 | @ TOR | 36 | L 6-7 | 17-19 | 3 | 23,214 | Rich Yett | John Cerutti | Tom Henke | Keith Atherton | Duane Ward | 156 | 144 | 12 |
| 1989-05-17 | @ TOR | 37 | W 6-3 | 18-19 | 1 | 24,406 | Buddy Black | Dave Stieb | Buddy Black | Dave Stieb | Doug Jones | 162 | 147 | 15 |
| 1989-05-18 | @ BAL | 38 | L 2-3 | 18-20 | 2 | 23,576 | Greg Swindell | Bob Milacki | Mark Williamson | Keith Atherton | | 164 | 150 | 14 |
| 1989-05-19 | @ BAL | 39 | W 4-1 | 19-20 | 2 | 21,933 | Tom Candiotti | Jose Bautista | Tom Candiotti | Jose Bautista | Doug Jones | 168 | 151 | 17 |
| 1989-05-20 | @ BAL | 40 | L 1-5 | 19-21 | 2 | 30,372 | John Farrell | Jeff Ballard | Jeff Ballard | John Farrell | | 169 | 156 | 13 |
| 1989-05-21 | @ BAL | 41 | W 2-0 | 20-21 | 1 | 35,428 | Rich Yett | Brian Holton | Rich Yett | Brian Holton | Doug Jones | 171 | 156 | 15 |
| 1989-05-22 | @ DET | 42 | W 7-3 | 21-21 | 1 | 13,702 | Buddy Black | Jack Morris | Buddy Black | Jack Morris | Jesse Orosco | 178 | 159 | 19 |
| 1989-05-23 | @ DET | 43 | L 2-7 | 21-22 | 1 | 13,141 | Greg Swindell | Mike Trujillo | Mike Trujillo | Greg Swindell | | 180 | 166 | 14 |
| 1989-05-24 | @ DET | 44 | L 1-2 | 21-23 | 3 | 14,352 | Tom Candiotti | Doyle Alexander | Guillermo Hernandez | Scott Bailes | | 181 | 168 | 13 |
| 1989-05-25 | @ DET | 45 | L 5-9 | 21-24 | 4 | 20,594 | John Farrell | Frank Tanana | Frank Tanana | John Farrell | Guillermo Hernandez | 186 | 177 | 9 |
| 1989-05-26 | vs BAL | 46 | L 2-5 | 21-25 | 4 | 20,515 | Rich Yett | Jeff Ballard | Jeff Ballard | Rich Yett | Gregg Olson | 188 | 182 | 6 |
| 1989-05-27 | vs BAL | 47 | L 1-5 | 21-26 | 4 | 13,260 | Buddy Black | Dave J. Schmidt | Dave J. Schmidt | Buddy Black | Mark Huismann | 189 | 187 | 2 |
| 1989-05-28 | vs BAL | 48 | W 1-0 | 22-26 | 3 | 33,918 | Greg Swindell | Bob Milacki | Greg Swindell | Bob Milacki | | 190 | 187 | 3 |
| 1989-05-29 | vs TOR | 49 | W 5-3 | 23-26 | 3 | 19,947 | Tom Candiotti | Mike Flanagan | Tom Candiotti | Mike Flanagan | Doug Jones | 195 | 190 | 5 |
| 1989-05-30 | vs TOR | 50 | W 6-2 | 24-26 | 3 | 6,204 | John Farrell | Alex Sanchez | John Farrell | Alex Sanchez | | 201 | 192 | 9 |
| 1989-05-31 | vs TOR | 51 | W 7-4 | 25-26 | 3 | 12,890 | Rich Yett | Jimmy Key | Buddy Black | Jimmy Key | Doug Jones | 208 | 196 | 12 |
| 1989-06-02 | @ OAK | 52 | W 5-3 | 26-26 | 2 | 28,052 | Greg Swindell | Mike Moore | Greg Swindell | Mike Moore | Doug Jones | 213 | 199 | 14 |
| 1989-06-03 | @ OAK | 53 | L 0-7 | 26-27 | 2 | 35,466 | Tom Candiotti | Bob Welch | Bob Welch | Tom Candiotti | | 213 | 206 | 7 |
| 1989-06-04 | @ OAK | 54 | L 0-4 | 26-28 | 2 | 34,610 | John Farrell | Dave Stewart | Dave Stewart | John Farrell | | 213 | 210 | 3 |
| 1989-06-05 | @ CAL | 55 | W 7-3 | 27-28 | 2 | 24,188 | Buddy Black | Mike Witt | Buddy Black | Mike Witt | | 220 | 213 | 7 |
| 1989-06-06 | @ CAL | 56 | L 1-2 | 27-29 | 2 | 22,586 | Rich Yett | Dan Petry | Dan Petry | Rich Yett | Bryan Harvey | 221 | 215 | 6 |
| 1989-06-07 | @ CAL | 57 | W 1-0 | 28-29 | 2 | 26,536 | Greg Swindell | Chuck Finley | Greg Swindell | Chuck Finley | | 222 | 215 | 7 |
| 1989-06-09 | vs SEA | 58 | W 5-4 | 29-29 | 2 | 59,671 | Tom Candiotti | Clint Zavaras | Tom Candiotti | Clint Zavaras | Doug Jones | 227 | 219 | 8 |
| 1989-06-10 | vs SEA | 59 | L 1-3 | 29-30 | 2 | 11,480 | John Farrell | Randy Johnson | Randy Johnson | John Farrell | Mike Schooler | 228 | 222 | 6 |
| 1989-06-11 | vs SEA | 60 | L 3-6 | 29-31 | 2 | 25,390 | Buddy Black | Brian Holman | Brian Holman | Buddy Black | Gene Harris | 231 | 228 | 3 |
| 1989-06-12 | @ CHA | 61 | L 3-5 | 29-32 | 3 | 9,587 | Rich Yett | Steve Rosenberg | Steve Rosenberg | Rich Yett | Bobby Thigpen | 234 | 233 | 1 |
| 1989-06-13 | @ CHA | 62 | W 9-6 | 30-32 | 2 | 10,264 | Greg Swindell | Adam Peterson | Greg Swindell | Adam Peterson | Doug Jones | 243 | 239 | 4 |
| 1989-06-14 | @ CHA | 63 | L 1-3 | 30-33 | 3 | 8,993 | Tom Candiotti | Jerry Reuss | Jerry Reuss | Tom Candiotti | Bobby Thigpen | 244 | 242 | 2 |
| 1989-06-15 | vs KCA | 64 | L 4-5 | 30-34 | 3 | 3,661 | John Farrell | Bret Saberhagen | Bret Saberhagen | Doug Jones | Steve Farr | 248 | 247 | 1 |
| 1989-06-16 | vs KCA | 65 | W 1-0 | 31-34 | 3 | 11,916 | Buddy Black | Luis Aquino | Buddy Black | Terry Leach | | 249 | 247 | 2 |
| 1989-06-17 | vs KCA | 66 | W 4-3 | 32-34 | 3 | 17,040 | Scott Bailes | Mark Gubicza | Scott Bailes | Mark Gubicza | Doug Jones | 253 | 250 | 3 |
| 1989-06-18 | vs KCA | 67 | W 4-1 | 33-34 | 2 | 28,928 | Greg Swindell | Kevin Appier | Greg Swindell | Kevin Appier | | 257 | 251 | 6 |
| 1989-06-20 | vs MIN | 68 | L 4-7 | 33-35 | 3 | 16,384 | Tom Candiotti | Allan Anderson | Allan Anderson | Tom Candiotti | Jeff Reardon | 261 | 258 | 3 |
| 1989-06-21 | vs MIN | 69 | L 1-5 | 33-36 | 4 | 8,632 | John Farrell | Shane Rawley | Shane Rawley | John Farrell | Randy St. Claire | 262 | 263 | -1 |
| 1989-06-22 | vs MIN | 70 | L 8-9 | 33-37 | 5 | 8,892 | Buddy Black | Roy Smith | Gary Wayne | Jesse Orosco | Jeff Reardon | 270 | 272 | -2 |
| 1989-06-23 | @ TEX | 71 | L 0-4 | 33-38 | 6 | 25,490 | Scott Bailes | Mike Jeffcoat | Mike Jeffcoat | Scott Bailes | | 270 | 276 | -6 |
| 1989-06-24 | @ TEX | 72 | W 7-3 | 34-38 | 5 | 39,496 | Greg Swindell | Charlie Hough | Greg Swindell | Charlie Hough | Doug Jones | 277 | 279 | -2 |
| 1989-06-25 | @ TEX | 73 | L 2-4 | 34-39 | 6 | 23,606 | Tom Candiotti | Nolan Ryan | Nolan Ryan | Tom Candiotti | Jeff Russell | 279 | 283 | -4 |
| 1989-06-26 | @ TEX | 74 | W 4-3 | 35-39 | 5 | 17,676 | John Farrell | Bobby Witt | John Farrell | Bobby Witt | Doug Jones | 283 | 286 | -3 |
| 1989-06-27 | vs CAL | 75 | L 1-2 | 35-40 | 6 | 17,281 | Buddy Black | Bert Blyleven | Rich Monteleone | Neil Allen | Bryan Harvey | 284 | 288 | -4 |
| 1989-06-28 | vs CAL | 76 | W 2-1 | 36-40 | 4 | 11,211 | Scott Bailes | Jim Abbott | Scott Bailes | Jim Abbott | Doug Jones | 286 | 289 | -3 |
| 1989-06-30 | vs OAK | 77 | L 0-5 | 36-41 | 6 | 27,435 | Greg Swindell | Bob Welch | Bob Welch | Greg Swindell | Rick Honeycutt | 286 | 294 | -8 |
| 1989-07-01 | vs OAK | 78 | L 4-6 | 36-42 | 6 | 18,826 | Tom Candiotti | Mike Moore | Mike Moore | Rich Yett | Todd Burns | 290 | 300 | -10 |
| 1989-07-02 | vs OAK | 79 | L 3-11 | 36-43 | 6 | 22,549 | John Farrell | Storm Davis | Storm Davis | John Farrell | | 293 | 311 | -18 |
| 1989-07-03 | vs CHA | 80 | W 4-2 | 37-43 | 6 | 53,046 | Buddy Black | Steve Rosenberg | Buddy Black | Shawn Hillegas | Doug Jones | 297 | 313 | -16 |
| 1989-07-04 | vs CHA | 81 | W 3-2 | 38-43 | 5 | 8,319 | Scott Bailes | Melido Perez | Scott Bailes | Melido Perez | Doug Jones | 300 | 315 | -15 |
| 1989-07-05 | vs CHA | 82 | W 4-2 | 39-43 | 5 | 11,476 | Greg Swindell | Jerry Reuss | Greg Swindell | Jerry Reuss | Doug Jones | 304 | 317 | -13 |
| 1989-07-07 | @ SEA | 83 | W 4-3 | 40-43 | 5 | 12,096 | John Farrell | Randy Johnson | Doug Jones | Michael Jackson | | 308 | 320 | -12 |
| 1989-07-08 | @ SEA | 84 | L 3-4 | 40-44 | 6 | 15,229 | Buddy Black | Brian Holman | Bill Swift | Jesse Orosco | | 311 | 324 | -13 |
| 1989-07-09 | @ SEA | 85 | L 0-8 | 40-45 | 6 | 14,022 | Scott Bailes | Scott Bankhead | Scott Bankhead | Scott Bailes | | 311 | 332 | -21 |
| 1989-07-13 | vs TEX | 86 | L 3-9 | 40-46 | 6 | 11,300 | Buddy Black | Bobby Witt | Jeff Russell | Rod Nichols | | 314 | 341 | -27 |
| 1989-07-14 | vs TEX | 87 | W 11-5 | 41-46 | 6 | 14,511 | John Farrell | Charlie Hough | Jesse Orosco | Cecilio Guante | Doug Jones | 325 | 346 | -21 |
| 1989-07-15 | vs TEX | 88 | W 7-1 | 42-46 | 5 | 28,952 | Greg Swindell | Nolan Ryan | Greg Swindell | Nolan Ryan | | 332 | 347 | -15 |
| 1989-07-16 | vs TEX | 89 | W 11-5 | 43-46 | 5 | 22,095 | Scott Bailes | Kevin Brown | Rich Yett | Kevin Brown | | 343 | 352 | -9 |
| 1989-07-17 | @ MIN | 90 | L 2-5 | 43-47 | 5 | 21,004 | Tom Candiotti | Mike Dyer | Juan Berenguer | Doug Jones | Jeff Reardon | 345 | 357 | -12 |
| 1989-07-18 | @ MIN | 91 | L 4-5 | 43-48 | 5 | 24,016 | Buddy Black | Frank Viola | Frank Viola | Doug Jones | | 349 | 362 | -13 |
| 1989-07-19 | @ MIN | 92 | W 10-1 | 44-48 | 5 | 22,504 | John Farrell | Allan Anderson | John Farrell | Allan Anderson | | 359 | 363 | -4 |
| 1989-07-20 | @ KCA | 93 | W 4-0 | 45-48 | 5 | 38,595 | Greg Swindell | Bret Saberhagen | Greg Swindell | Bret Saberhagen | | 363 | 363 | 0 |
| 1989-07-21 | @ KCA | 94 | L 1-6 | 45-49 | 5 | 38,274 | Scott Bailes | Luis Aquino | Luis Aquino | Scott Bailes | Jeff Montgomery | 364 | 369 | -5 |
| 1989-07-22 | @ KCA | 95 | W 1-0 | 46-49 | 3 | 38,606 | Tom Candiotti | Tom Gordon | Tom Candiotti | Tom Gordon | Doug Jones | 365 | 369 | -4 |
| 1989-07-23 | @ KCA | 96 | W 17-5 | 47-49 | 3 | 33,991 | Buddy Black | Mark Gubicza | Buddy Black | Mark Gubicza | | 382 | 374 | 8 |
| 1989-07-24 | vs NYA | 97 | W 7-3 | 48-49 | 3 | 23,794 | John Farrell | Clay Parker | John Farrell | Lee Guetterman | | 389 | 377 | 12 |
| 1989-07-25 | vs NYA | 98 | L 1-5 | 48-50 | 3 | 40,496 | Greg Swindell | Andy Hawkins | Andy Hawkins | Greg Swindell | | 390 | 382 | 8 |
| 1989-07-26 | vs NYA | 99 | W 9-7 | 49-50 | 3 | 21,374 | Scott Bailes | Walt Terrell | Doug Jones | Lee Guetterman | | 399 | 389 | 10 |
| 1989-07-28 | vs BOS | 100 | W 3-2 | 51-50 | 2 | 0 | Tom Candiotti | Roger Clemens | Tom Candiotti | Roger Clemens | | 402 | 391 | 11 |
| 1989-07-28 | vs BOS | 101 | W 2-1 | 51-50 | 2 | 35,792 | Rod Nichols | Wes Gardner | Rod Nichols | Wes Gardner | Doug Jones | 404 | 392 | 12 |
| 1989-07-29 | vs BOS | 102 | L 0-5 | 51-51 | 2 | 26,146 | Buddy Black | Mike Smithson | Mike Smithson | Buddy Black | | 404 | 397 | 7 |
| 1989-07-30 | vs BOS | 103 | L 2-5 | 51-52 | 2 | 25,022 | John Farrell | Mike Boddicker | Dennis Lamp | John Farrell | Rob Murphy | 406 | 402 | 4 |
| 1989-07-31 | @ MIL | 104 | L 1-6 | 51-53 | 4 | 17,434 | Scott Bailes | Teddy Higuera | Teddy Higuera | Scott Bailes | Chuck Crim | 407 | 408 | -1 |
| 1989-08-01 | @ MIL | 105 | L 2-4 | 51-54 | 5 | 22,396 | Ed Wojna | Jaime Navarro | Jaime Navarro | Doug Jones | Dan Plesac | 409 | 412 | -3 |
| 1989-08-02 | @ MIL | 106 | W 1-0 | 52-54 | 4 | 25,813 | Tom Candiotti | Chris Bosio | Tom Candiotti | Chris Bosio | Jesse Orosco | 410 | 412 | -2 |
| 1989-08-03 | @ BOS | 107 | W 4-2 | 53-54 | 2 | 33,992 | Rod Nichols | Tom Bolton | Rod Nichols | Tom Bolton | Doug Jones | 414 | 414 | 0 |
| 1989-08-04 | @ BOS | 108 | W 4-3 | 54-54 | 2 | 34,154 | Buddy Black | Mike Boddicker | Buddy Black | Mike Boddicker | Doug Jones | 418 | 417 | 1 |
| 1989-08-05 | @ BOS | 109 | L 2-10 | 54-55 | 2 | 34,090 | John Farrell | Mike Smithson | Mike Smithson | John Farrell | | 420 | 427 | -7 |
| 1989-08-06 | @ BOS | 110 | L 4-6 | 54-56 | 4 | 33,935 | Ed Wojna | Roger Clemens | Rob Murphy | Jesse Orosco | | 424 | 433 | -9 |
| 1989-08-07 | @ NYA | 111 | L 0-9 | 54-57 | 4 | 21,794 | Scott Bailes | Greg Cadaret | Greg Cadaret | Scott Bailes | | 424 | 442 | -18 |
| 1989-08-08 | @ NYA | 112 | W 3-1 | 55-57 | 3 | 25,192 | Tom Candiotti | Chuck Cary | Tom Candiotti | Chuck Cary | Doug Jones | 427 | 443 | -16 |
| 1989-08-09 | @ NYA | 113 | W 7-4 | 56-57 | 3 | 31,121 | Rod Nichols | Andy Hawkins | Rod Nichols | Andy Hawkins | Steve Olin | 434 | 447 | -13 |
| 1989-08-10 | vs MIL | 114 | L 3-10 | 56-58 | 4 | 15,506 | Buddy Black | Teddy Higuera | Teddy Higuera | Buddy Black | | 437 | 457 | -20 |
| 1989-08-11 | vs MIL | 115 | W 5-0 | 57-59 | 4 | 0 | John Farrell | Jaime Navarro | John Farrell | Jaime Navarro | | 442 | 457 | -15 |
| 1989-08-11 | vs MIL | 116 | L 7-8 | 57-59 | 4 | 47,795 | Ed Wojna | Mark Knudson | Mark Knudson | Ed Wojna | Dan Plesac | 449 | 465 | -16 |
| 1989-08-12 | vs MIL | 117 | L 1-5 | 57-60 | 5 | 21,325 | Scott Bailes | Chris Bosio | Chris Bosio | Scott Bailes | | 450 | 470 | -20 |
| 1989-08-13 | vs MIL | 118 | L 4-5 | 57-61 | 5 | 22,344 | Tom Candiotti | Tom Filer | Dan Plesac | Doug Jones | | 454 | 475 | -21 |
| 1989-08-15 | @ OAK | 119 | L 2-5 | 57-62 | 5 | 28,459 | Rod Nichols | Storm Davis | Storm Davis | Rod Nichols | Dennis Eckersley | 456 | 480 | -24 |
| 1989-08-16 | @ OAK | 120 | W 6-3 | 58-62 | 4 | 29,502 | Buddy Black | Mike Moore | Steve Olin | Rick Honeycutt | Doug Jones | 462 | 483 | -21 |
| 1989-08-17 | @ OAK | 121 | L 0-1 | 58-63 | 4 | 35,071 | John Farrell | Bob Welch | Bob Welch | John Farrell | Dennis Eckersley | 462 | 484 | -22 |
| 1989-08-18 | @ CAL | 122 | L 5-6 | 58-64 | 4 | 52,286 | Tom Candiotti | Jim Abbott | Greg Minton | Steve Olin | Bryan Harvey | 467 | 490 | -23 |
| 1989-08-19 | @ CAL | 123 | L 4-7 | 58-65 | 5 | 40,574 | Rod Nichols | Bert Blyleven | Bert Blyleven | Rod Nichols | Greg Minton | 471 | 497 | -26 |
| 1989-08-20 | @ CAL | 124 | L 0-1 | 58-66 | 5 | 32,640 | Buddy Black | Kirk McCaskill | Kirk McCaskill | Buddy Black | | 471 | 498 | -27 |
| 1989-08-22 | vs SEA | 125 | W 3-2 | 59-66 | 5 | 12,565 | John Farrell | Scott Bankhead | Doug Jones | Mike Schooler | | 474 | 500 | -26 |
| 1989-08-23 | vs SEA | 126 | W 5-3 | 60-66 | 5 | 9,618 | Tom Candiotti | Mike Dunne | Tom Candiotti | Mike Dunne | Doug Jones | 479 | 503 | -24 |
| 1989-08-24 | vs SEA | 127 | W 5-2 | 61-66 | 4 | 12,726 | Steve Davis | Clint Zavaras | Steve Davis | Clint Zavaras | Doug Jones | 484 | 505 | -21 |
| 1989-08-25 | vs CHA | 128 | L 4-5 | 61-67 | 5 | 20,033 | Rod Nichols | Richard Dotson | Richard Dotson | Jesse Orosco | Bobby Thigpen | 488 | 510 | -22 |
| 1989-08-26 | vs CHA | 129 | L 3-4 | 61-68 | 5 | 14,469 | Buddy Black | Steve Rosenberg | Steve Rosenberg | Buddy Black | Bobby Thigpen | 491 | 514 | -23 |
| 1989-08-27 | vs CHA | 130 | L 3-9 | 61-69 | 5 | 24,835 | John Farrell | Greg Hibbard | Greg Hibbard | John Farrell | | 494 | 523 | -29 |
| 1989-08-29 | vs BAL | 131 | W 3-1 | 62-69 | 5 | 10,035 | Tom Candiotti | Pete Harnisch | Doug Jones | Pete Harnisch | | 497 | 524 | -27 |
| 1989-08-30 | vs BAL | 132 | L 4-7 | 62-70 | 5 | 13,020 | Greg Swindell | Jeff Ballard | Jeff Ballard | Greg Swindell | Gregg Olson | 501 | 531 | -30 |
| 1989-08-31 | vs BAL | 133 | W 11-0 | 63-70 | 5 | 9,735 | John Farrell | Dave Johnson | John Farrell | Dave Johnson | | 512 | 531 | -19 |
| 1989-09-01 | @ DET | 134 | L 1-2 | 63-71 | 5 | 14,576 | Buddy Black | Frank Tanana | Paul Gibson | Doug Jones | | 513 | 533 | -20 |
| 1989-09-02 | @ DET | 135 | L 4-10 | 63-72 | 5 | 17,207 | Steve Davis | Jeff Robinson | Jeff Robinson | Steve Davis | | 517 | 543 | -26 |
| 1989-09-03 | @ DET | 136 | L 3-12 | 63-73 | 5 | 18,130 | Tom Candiotti | Jack Morris | Jack Morris | Tom Candiotti | | 520 | 555 | -35 |
| 1989-09-04 | @ BAL | 137 | L 4-5 | 63-74 | 5 | 32,875 | Greg Swindell | Dave Johnson | Mark Williamson | Rod Nichols | | 524 | 560 | -36 |
| 1989-09-05 | @ BAL | 138 | L 1-3 | 63-75 | 6 | 19,985 | John Farrell | Bob Milacki | Bob Milacki | John Farrell | Gregg Olson | 525 | 563 | -38 |
| 1989-09-06 | @ BAL | 139 | W 9-0 | 64-75 | 6 | 29,405 | Buddy Black | Curt Schilling | Buddy Black | Curt Schilling | | 534 | 563 | -29 |
| 1989-09-07 | vs TOR | 140 | L 4-12 | 64-76 | 6 | 6,098 | Tom Candiotti | John Cerutti | John Cerutti | Tom Candiotti | | 538 | 575 | -37 |
| 1989-09-08 | vs TOR | 141 | W 5-4 | 65-76 | 6 | 13,489 | Rod Nichols | Mike Flanagan | Doug Jones | Jim Acker | | 543 | 579 | -36 |
| 1989-09-09 | vs TOR | 142 | L 5-7 | 65-77 | 6 | 15,154 | Greg Swindell | Jimmy Key | Frank Wills | Jeff Kaiser | | 548 | 586 | -38 |
| 1989-09-10 | vs TOR | 143 | L 4-5 | 65-78 | 6 | 12,045 | John Farrell | Dave Stieb | Jim Acker | Steve Olin | | 552 | 591 | -39 |
| 1989-09-12 | vs DET | 144 | W 1-0 | 66-78 | 6 | 5,523 | Buddy Black | Frank Tanana | Buddy Black | Frank Tanana | | 553 | 591 | -38 |
| 1989-09-13 | vs DET | 145 | L 1-3 | 66-79 | 6 | 5,068 | Tom Candiotti | Jack Morris | Jack Morris | Tom Candiotti | | 554 | 594 | -40 |
| 1989-09-14 | vs DET | 146 | W 4-0 | 67-79 | 5 | 7,300 | Rod Nichols | Kevin Ritz | Rod Nichols | Kevin Ritz | Jesse Orosco | 558 | 594 | -36 |
| 1989-09-15 | @ TOR | 147 | L 2-5 | 67-80 | 5 | 49,444 | Greg Swindell | Jimmy Key | Jimmy Key | Greg Swindell | Tom Henke | 560 | 599 | -39 |
| 1989-09-16 | @ TOR | 148 | L 2-3 | 67-81 | 6 | 49,218 | John Farrell | Dave Stieb | David Wells | Doug Jones | | 562 | 602 | -40 |
| 1989-09-17 | @ TOR | 149 | L 1-2 | 67-82 | 6 | 49,501 | Buddy Black | Todd Stottlemyre | Jim Acker | Scott Bailes | | 563 | 604 | -41 |
| 1989-09-18 | vs OAK | 150 | L 2-4 | 67-83 | 6 | 5,931 | Tom Candiotti | Dave Stewart | Dennis Eckersley | Steve Olin | | 565 | 608 | -43 |
| 1989-09-19 | vs OAK | 151 | L 1-5 | 67-84 | 6 | 6,085 | Rod Nichols | Mike Moore | Mike Moore | Rod Nichols | | 566 | 613 | -47 |
| 1989-09-20 | vs OAK | 152 | L 6-8 | 67-85 | 6 | 6,186 | Greg Swindell | Storm Davis | Storm Davis | Greg Swindell | Dennis Eckersley | 572 | 621 | -49 |
| 1989-09-21 | vs CAL | 153 | W 5-4 | 68-85 | 6 | 4,735 | John Farrell | Kirk McCaskill | Scott Bailes | Rich Monteleone | | 577 | 625 | -48 |
| 1989-09-23 | vs CAL | 154 | W 4-3 | 70-85 | 6 | 0 | Buddy Black | Mike Witt | Buddy Black | Mike Witt | Doug Jones | 581 | 628 | -47 |
| 1989-09-23 | vs CAL | 155 | W 6-2 | 70-85 | 6 | 8,453 | Tom Candiotti | Bert Blyleven | Tom Candiotti | Bert Blyleven | | 587 | 630 | -43 |
| 1989-09-24 | vs CAL | 156 | W 5-4 | 71-85 | 6 | 14,841 | Rod Nichols | Chuck Finley | Jesse Orosco | Willie Fraser | | 592 | 634 | -42 |
| 1989-09-26 | @ SEA | 157 | L 2-3 | 71-86 | 5 | 6,768 | Greg Swindell | Erik Hanson | Erik Hanson | Doug Jones | Mike Schooler | 594 | 637 | -43 |
| 1989-09-27 | @ SEA | 158 | W 4-1 | 72-86 | 5 | 6,652 | John Farrell | Randy Johnson | John Farrell | Randy Johnson | | 598 | 638 | -40 |
| 1989-09-28 | @ SEA | 159 | L 2-6 | 72-87 | 6 | 6,831 | Buddy Black | Brian Holman | Brian Holman | Steve Olin | | 600 | 644 | -44 |
| 1989-09-29 | @ CHA | 160 | L 1-2 | 72-88 | 6 | 8,133 | Tom Candiotti | Eric King | Eric King | Tom Candiotti | Bobby Thigpen | 601 | 646 | -45 |
| 1989-09-30 | @ CHA | 161 | L 2-8 | 72-89 | 6 | 13,189 | Rod Nichols | Greg Hibbard | Greg Hibbard | Rod Nichols | Bill Long | 603 | 654 | -51 |
| 1989-10-01 | @ CHA | 162 | W 1-0 | 73-89 | 6 | 12,856 | Greg Swindell | Richard Dotson | Jesse Orosco | Richard Dotson | Doug Jones | 604 | 654 | -50 |