| 1989-04-04 | @ CAL | 1 | W 9-2 | 1-0 | 1 | 33,265 | Jerry Reuss | Mike Witt | Jerry Reuss | Mike Witt | Donn Pall | 9 | 2 | 7 |
| 1989-04-05 | @ CAL | 2 | L 2-6 | 1-1 | 3 | 20,969 | Eric King | Chuck Finley | Chuck Finley | Eric King | Greg Minton | 11 | 8 | 3 |
| 1989-04-06 | @ CAL | 3 | W 3-2 | 2-1 | 3 | 20,667 | Shawn Hillegas | Bert Blyleven | Ken Patterson | Willie Fraser | Donn Pall | 14 | 10 | 4 |
| 1989-04-07 | @ OAK | 4 | W 7-1 | 3-1 | 1 | 20,585 | Bill Long | Curt Young | Bill Long | Curt Young | Barry Jones | 21 | 11 | 10 |
| 1989-04-08 | @ OAK | 5 | W 7-4 | 4-1 | 1 | 32,881 | Melido Perez | Mike Moore | Melido Perez | Mike Moore | Bobby Thigpen | 28 | 15 | 13 |
| 1989-04-09 | @ OAK | 6 | L 2-4 | 4-2 | 2 | 45,110 | Jerry Reuss | Dave Stewart | Dave Stewart | Jerry Reuss | Dennis Eckersley | 30 | 19 | 11 |
| 1989-04-10 | @ SEA | 7 | L 5-6 | 4-3 | 5 | 33,866 | Eric King | Scott Bankhead | Jerry Reed | Eric King | Mike Schooler | 35 | 25 | 10 |
| 1989-04-11 | @ SEA | 8 | W 8-6 | 5-3 | 4 | 8,088 | Shawn Hillegas | Mike Campbell | Barry Jones | Tom Niedenfuer | Bobby Thigpen | 43 | 31 | 12 |
| 1989-04-12 | @ SEA | 9 | L 1-9 | 5-4 | 4 | 8,190 | Bill Long | Erik Hanson | Erik Hanson | Bill Long | | 44 | 40 | 4 |
| 1989-04-14 | vs OAK | 10 | L 4-7 | 5-5 | 5 | 37,950 | Melido Perez | Dave Stewart | Dave Stewart | Melido Perez | | 48 | 47 | 1 |
| 1989-04-15 | vs OAK | 11 | W 7-4 | 6-5 | 5 | 15,748 | Jerry Reuss | Bob Welch | Jerry Reuss | Bob Welch | Bobby Thigpen | 55 | 51 | 4 |
| 1989-04-16 | vs OAK | 12 | L 2-3 | 6-6 | 6 | 20,969 | Eric King | Storm Davis | Dennis Eckersley | Eric King | | 57 | 54 | 3 |
| 1989-04-17 | vs CAL | 13 | L 0-3 | 6-7 | 6 | 6,392 | Shawn Hillegas | Kirk McCaskill | Kirk McCaskill | Shawn Hillegas | Bryan Harvey | 57 | 57 | 0 |
| 1989-04-19 | vs CAL | 14 | L 2-7 | 6-8 | 6 | 6,897 | Bill Long | Mike Witt | Mike Witt | Bill Long | Greg Minton | 59 | 64 | -5 |
| 1989-04-20 | vs SEA | 15 | L 2-5 | 6-9 | 6 | 6,467 | Melido Perez | Scott Bankhead | Scott Bankhead | Barry Jones | | 61 | 69 | -8 |
| 1989-04-21 | vs SEA | 16 | L 1-11 | 6-10 | 7 | 7,652 | Jerry Reuss | Mike Campbell | Mike Campbell | Jerry Reuss | | 62 | 80 | -18 |
| 1989-04-22 | vs SEA | 17 | W 1-0 | 7-10 | 6 | 15,007 | Eric King | Erik Hanson | Eric King | Erik Hanson | | 63 | 80 | -17 |
| 1989-04-23 | vs SEA | 18 | L 6-10 | 7-11 | 7 | 11,216 | Shawn Hillegas | Steve Trout | Steve Trout | Shawn Hillegas | | 69 | 90 | -21 |
| 1989-04-25 | @ BOS | 19 | L 0-11 | 7-12 | 7 | 21,326 | Melido Perez | Roger Clemens | Roger Clemens | Melido Perez | | 69 | 101 | -32 |
| 1989-04-26 | @ BOS | 20 | L 4-5 | 7-13 | 7 | 22,948 | Jerry Reuss | Oil Can Boyd | Bob Stanley | Barry Jones | | 73 | 106 | -33 |
| 1989-04-27 | @ BOS | 21 | W 3-1 | 8-13 | 7 | 23,830 | Eric King | John Dopson | Donn Pall | Mike Smithson | | 76 | 107 | -31 |
| 1989-04-28 | @ NYA | 22 | L 1-3 | 8-14 | 7 | 26,984 | Shawn Hillegas | Andy Hawkins | Andy Hawkins | Shawn Hillegas | Dave Righetti | 77 | 110 | -33 |
| 1989-04-29 | @ NYA | 23 | L 2-8 | 8-15 | 7 | 18,578 | Bill Long | Dave LaPoint | Dave LaPoint | Bill Long | Dale Mohorcic | 79 | 118 | -39 |
| 1989-04-30 | @ NYA | 24 | L 2-5 | 8-16 | 7 | 35,813 | Melido Perez | John Candelaria | John Candelaria | Melido Perez | Lance McCullers | 81 | 123 | -42 |
| 1989-05-01 | vs MIL | 25 | W 6-0 | 9-16 | 7 | 7,625 | Jerry Reuss | Teddy Higuera | Jerry Reuss | Teddy Higuera | | 87 | 123 | -36 |
| 1989-05-02 | vs MIL | 26 | W 6-1 | 10-16 | 7 | 6,534 | Eric King | Chris Bosio | Eric King | Chris Bosio | | 93 | 124 | -31 |
| 1989-05-03 | vs BOS | 27 | L 4-8 | 10-17 | 7 | 8,688 | Shawn Hillegas | Mike Boddicker | Mike Boddicker | Shawn Hillegas | Bob Stanley | 97 | 132 | -35 |
| 1989-05-04 | vs BOS | 28 | W 5-4 | 11-17 | 6 | 7,443 | Bill Long | Wes Gardner | Bill Long | Wes Gardner | Bobby Thigpen | 102 | 136 | -34 |
| 1989-05-05 | vs NYA | 29 | L 5-7 | 11-18 | 7 | 14,996 | Melido Perez | John Candelaria | Lance McCullers | Donn Pall | Lee Guetterman | 107 | 143 | -36 |
| 1989-05-06 | vs NYA | 30 | L 2-5 | 11-19 | 7 | 16,617 | Jerry Reuss | Richard Dotson | Dave Righetti | Steve Rosenberg | | 109 | 148 | -39 |
| 1989-05-07 | vs NYA | 31 | W 6-2 | 12-19 | 6 | 20,603 | Eric King | Tommy John | Eric King | Tommy John | Bobby Thigpen | 115 | 150 | -35 |
| 1989-05-09 | @ MIL | 32 | W 10-1 | 13-19 | 7 | 9,475 | Shawn Hillegas | Bill Wegman | Shawn Hillegas | Bill Wegman | | 125 | 151 | -26 |
| 1989-05-10 | @ MIL | 33 | W 12-2 | 14-19 | 6 | 16,172 | Melido Perez | Teddy Higuera | Melido Perez | Teddy Higuera | | 137 | 153 | -16 |
| 1989-05-12 | @ BAL | 34 | L 6-9 | 14-20 | 7 | 20,484 | Jerry Reuss | Dave J. Schmidt | Mark Thurmond | Tom McCarthy | Kevin Hickey | 143 | 162 | -19 |
| 1989-05-13 | @ BAL | 35 | W 8-2 | 15-20 | 7 | 23,032 | Eric King | Bob Milacki | Eric King | Bob Milacki | | 151 | 164 | -13 |
| 1989-05-14 | @ BAL | 36 | W 8-5 | 16-20 | 7 | 35,124 | Shawn Hillegas | Jose Bautista | Steve Rosenberg | Mark Williamson | Bobby Thigpen | 159 | 169 | -10 |
| 1989-05-15 | @ DET | 37 | L 2-3 | 16-21 | 7 | 12,035 | Bill Long | Frank Tanana | Frank Tanana | Bill Long | Guillermo Hernandez | 161 | 172 | -11 |
| 1989-05-16 | @ DET | 38 | L 7-9 | 16-22 | 7 | 13,861 | Melido Perez | Mike Trujillo | Frank Williams | Melido Perez | | 168 | 181 | -13 |
| 1989-05-17 | @ DET | 39 | W 10-7 | 17-22 | 7 | 15,975 | Jerry Reuss | Jack Morris | Ken Patterson | Guillermo Hernandez | Shawn Hillegas | 178 | 188 | -10 |
| 1989-05-19 | vs TOR | 40 | L 3-9 | 17-23 | 7 | 11,282 | Eric King | Mike Flanagan | Mike Flanagan | Eric King | | 181 | 197 | -16 |
| 1989-05-20 | vs TOR | 41 | L 1-11 | 17-24 | 7 | 18,029 | Shawn Hillegas | Jimmy Key | Jimmy Key | Shawn Hillegas | | 182 | 208 | -26 |
| 1989-05-21 | vs TOR | 42 | L 3-9 | 17-25 | 7 | 16,488 | Melido Perez | John Cerutti | John Cerutti | Melido Perez | Duane Ward | 185 | 217 | -32 |
| 1989-05-22 | vs BAL | 43 | L 1-5 | 17-26 | 7 | 8,528 | Steve Rosenberg | Dave J. Schmidt | Dave J. Schmidt | Steve Rosenberg | | 186 | 222 | -36 |
| 1989-05-23 | vs BAL | 44 | L 3-9 | 17-27 | 7 | 9,251 | Bill Long | Bob Milacki | Bob Milacki | Bill Long | | 189 | 231 | -42 |
| 1989-05-24 | vs BAL | 45 | L 0-8 | 17-28 | 7 | 7,911 | Eric King | Jay Tibbs | Jay Tibbs | Eric King | Mark Williamson | 189 | 239 | -50 |
| 1989-05-26 | @ TOR | 46 | L 3-11 | 17-29 | 7 | 30,105 | Shawn Hillegas | Jimmy Key | Jimmy Key | Shawn Hillegas | | 192 | 250 | -58 |
| 1989-05-27 | @ TOR | 47 | W 5-3 | 18-29 | 7 | 37,437 | Melido Perez | John Cerutti | Melido Perez | John Cerutti | Bobby Thigpen | 197 | 253 | -56 |
| 1989-05-28 | @ TOR | 48 | L 5-7 | 18-30 | 7 | 46,120 | Steve Rosenberg | Dave Stieb | Tom Henke | Bobby Thigpen | | 202 | 260 | -58 |
| 1989-05-29 | vs DET | 49 | L 2-4 | 18-31 | 7 | 12,425 | Eric King | Doyle Alexander | Doyle Alexander | Eric King | Guillermo Hernandez | 204 | 264 | -60 |
| 1989-05-30 | vs DET | 50 | L 3-10 | 18-32 | 7 | 9,227 | Jeff Bittiger | Frank Tanana | Frank Tanana | Jeff Bittiger | Frank Williams | 207 | 274 | -67 |
| 1989-05-31 | vs DET | 51 | L 3-4 | 18-33 | 7 | 8,549 | Greg Hibbard | Jeff Robinson | Mike Henneman | Bobby Thigpen | Guillermo Hernandez | 210 | 278 | -68 |
| 1989-06-02 | vs MIN | 52 | L 0-8 | 18-34 | 7 | 13,205 | Melido Perez | Allan Anderson | Allan Anderson | Melido Perez | | 210 | 286 | -76 |
| 1989-06-03 | vs MIN | 53 | L 4-5 | 19-35 | 7 | 0 | Eric King | Frank Viola | Frank Viola | Eric King | Jeff Reardon | 214 | 291 | -77 |
| 1989-06-03 | vs MIN | 54 | W 2-1 | 19-35 | 7 | 14,365 | Steve Rosenberg | Shane Rawley | Shawn Hillegas | Shane Rawley | Bobby Thigpen | 216 | 292 | -76 |
| 1989-06-04 | vs MIN | 55 | W 2-1 | 20-35 | 7 | 15,170 | Jerry Reuss | Roy Smith | Jerry Reuss | Roy Smith | Bobby Thigpen | 218 | 293 | -75 |
| 1989-06-05 | @ TEX | 56 | L 2-4 | 20-36 | 7 | 28,607 | Greg Hibbard | Bobby Witt | Bobby Witt | Greg Hibbard | Jeff Russell | 220 | 297 | -77 |
| 1989-06-06 | @ TEX | 57 | L 1-3 | 20-37 | 7 | 13,486 | Melido Perez | Kevin Brown | Kevin Brown | Melido Perez | Jeff Russell | 221 | 300 | -79 |
| 1989-06-07 | @ TEX | 58 | W 6-4 | 21-37 | 7 | 12,257 | Steve Rosenberg | Mike Jeffcoat | Ken Patterson | Cecilio Guante | Bobby Thigpen | 227 | 304 | -77 |
| 1989-06-08 | @ TEX | 59 | L 7-11 | 21-38 | 7 | 27,669 | Eric King | Nolan Ryan | Nolan Ryan | Eric King | Jeff Russell | 234 | 315 | -81 |
| 1989-06-09 | @ MIN | 60 | W 8-3 | 22-38 | 7 | 26,665 | Jerry Reuss | Shane Rawley | Jerry Reuss | Shane Rawley | Shawn Hillegas | 242 | 318 | -76 |
| 1989-06-10 | @ MIN | 61 | L 8-11 | 22-39 | 7 | 26,984 | Greg Hibbard | Francisco Oliveras | Juan Berenguer | Bobby Thigpen | Jeff Reardon | 250 | 329 | -79 |
| 1989-06-11 | @ MIN | 62 | L 2-5 | 22-40 | 7 | 38,015 | Melido Perez | Allan Anderson | Allan Anderson | Melido Perez | Jeff Reardon | 252 | 334 | -82 |
| 1989-06-12 | vs CLE | 63 | W 5-3 | 23-40 | 7 | 9,587 | Steve Rosenberg | Rich Yett | Steve Rosenberg | Rich Yett | Bobby Thigpen | 257 | 337 | -80 |
| 1989-06-13 | vs CLE | 64 | L 6-9 | 23-41 | 7 | 10,264 | Adam Peterson | Greg Swindell | Greg Swindell | Adam Peterson | Doug Jones | 263 | 346 | -83 |
| 1989-06-14 | vs CLE | 65 | W 3-1 | 24-41 | 7 | 8,993 | Jerry Reuss | Tom Candiotti | Jerry Reuss | Tom Candiotti | Bobby Thigpen | 266 | 347 | -81 |
| 1989-06-16 | vs BOS | 66 | L 0-2 | 24-42 | 7 | 16,898 | Greg Hibbard | Roger Clemens | Roger Clemens | Ken Patterson | | 266 | 349 | -83 |
| 1989-06-17 | vs BOS | 67 | L 1-6 | 24-43 | 7 | 25,258 | Melido Perez | Mike Smithson | Mike Smithson | Melido Perez | | 267 | 355 | -88 |
| 1989-06-18 | vs BOS | 68 | L 4-7 | 24-44 | 7 | 16,350 | Steve Rosenberg | Joe Price | Joe Price | Steve Rosenberg | Lee Smith | 271 | 362 | -91 |
| 1989-06-19 | vs BOS | 69 | W 8-2 | 25-44 | 7 | 12,712 | Adam Peterson | John Dopson | Shawn Hillegas | John Dopson | Donn Pall | 279 | 364 | -85 |
| 1989-06-20 | @ NYA | 70 | W 13-6 | 26-44 | 7 | 20,750 | Jerry Reuss | Richard Dotson | Jerry Reuss | Richard Dotson | John Davis | 292 | 370 | -78 |
| 1989-06-21 | @ NYA | 71 | W 7-3 | 27-44 | 7 | 20,404 | Greg Hibbard | Andy Hawkins | Donn Pall | Andy Hawkins | | 299 | 373 | -74 |
| 1989-06-22 | @ NYA | 72 | L 7-10 | 27-45 | 7 | 21,677 | Ken Patterson | Jimmy Jones | Greg Cadaret | Shawn Hillegas | Dave Righetti | 306 | 383 | -77 |
| 1989-06-23 | @ MIL | 73 | L 5-17 | 28-46 | 7 | 0 | Steve Rosenberg | Chris Bosio | Chris Bosio | Steve Rosenberg | | 311 | 400 | -89 |
| 1989-06-23 | @ MIL | 74 | W 6-4 | 28-46 | 7 | 28,702 | Melido Perez | Bryan Clutterbuck | Melido Perez | Bryan Clutterbuck | Bobby Thigpen | 317 | 404 | -87 |
| 1989-06-24 | @ MIL | 75 | W 5-3 | 29-46 | 7 | 52,021 | Bill Long | Bill Krueger | Bill Long | Bill Krueger | Bobby Thigpen | 322 | 407 | -85 |
| 1989-06-25 | @ MIL | 76 | L 1-3 | 29-47 | 7 | 40,201 | Jerry Reuss | Jaime Navarro | Jaime Navarro | Jerry Reuss | Dan Plesac | 323 | 410 | -87 |
| 1989-06-27 | vs TEX | 77 | L 1-5 | 29-48 | 7 | 9,631 | Greg Hibbard | Kevin Brown | Kevin Brown | Greg Hibbard | Jeff Russell | 324 | 415 | -91 |
| 1989-06-28 | vs TEX | 78 | L 5-10 | 29-49 | 7 | 8,622 | Steve Rosenberg | Mike Jeffcoat | Mike Jeffcoat | Steve Rosenberg | | 329 | 425 | -96 |
| 1989-06-29 | vs KCA | 79 | W 12-5 | 30-49 | 7 | 11,970 | Melido Perez | Bret Saberhagen | Melido Perez | Terry Leach | | 341 | 430 | -89 |
| 1989-06-30 | vs KCA | 80 | L 3-6 | 30-50 | 7 | 12,464 | Jerry Reuss | Charlie Leibrandt | Charlie Leibrandt | Jerry Reuss | Jeff Montgomery | 344 | 436 | -92 |
| 1989-07-01 | vs KCA | 81 | W 6-4 | 31-50 | 7 | 19,106 | Richard Dotson | Luis Aquino | Shawn Hillegas | Luis Aquino | Bobby Thigpen | 350 | 440 | -90 |
| 1989-07-02 | vs KCA | 82 | W 7-3 | 32-50 | 7 | 16,716 | Greg Hibbard | Kevin Appier | Greg Hibbard | Kevin Appier | Donn Pall | 357 | 443 | -86 |
| 1989-07-03 | @ CLE | 83 | L 2-4 | 32-51 | 7 | 53,046 | Steve Rosenberg | Buddy Black | Buddy Black | Shawn Hillegas | Doug Jones | 359 | 447 | -88 |
| 1989-07-04 | @ CLE | 84 | L 2-3 | 32-52 | 7 | 8,319 | Melido Perez | Scott Bailes | Scott Bailes | Melido Perez | Doug Jones | 361 | 450 | -89 |
| 1989-07-05 | @ CLE | 85 | L 2-4 | 32-53 | 7 | 11,476 | Jerry Reuss | Greg Swindell | Greg Swindell | Jerry Reuss | Doug Jones | 363 | 454 | -91 |
| 1989-07-07 | @ KCA | 86 | L 2-4 | 32-54 | 7 | 37,464 | Richard Dotson | Terry Leach | Terry Leach | Richard Dotson | Steve Farr | 365 | 458 | -93 |
| 1989-07-08 | @ KCA | 87 | L 3-4 | 32-55 | 7 | 39,869 | Greg Hibbard | Mark Gubicza | Jeff Montgomery | John Davis | | 368 | 462 | -94 |
| 1989-07-09 | @ KCA | 88 | L 4-5 | 32-56 | 7 | 30,456 | Steve Rosenberg | Bret Saberhagen | Tom Gordon | Shawn Hillegas | | 372 | 467 | -95 |
| 1989-07-13 | vs MIL | 89 | W 5-4 | 33-56 | 7 | 13,966 | Jerry Reuss | Don August | Bobby Thigpen | Tony Fossas | | 377 | 471 | -94 |
| 1989-07-14 | vs MIL | 90 | W 6-4 | 34-56 | 7 | 14,437 | Greg Hibbard | Chris Bosio | Bill Long | Chris Bosio | Donn Pall | 383 | 475 | -92 |
| 1989-07-15 | vs MIL | 91 | W 2-1 | 35-56 | 7 | 22,404 | Melido Perez | Teddy Higuera | Melido Perez | Teddy Higuera | Bobby Thigpen | 385 | 476 | -91 |
| 1989-07-16 | vs MIL | 92 | W 2-0 | 36-56 | 7 | 19,379 | Richard Dotson | Jaime Navarro | Richard Dotson | Jaime Navarro | Bobby Thigpen | 387 | 476 | -89 |
| 1989-07-17 | vs NYA | 93 | W 7-3 | 37-56 | 7 | 18,070 | Steve Rosenberg | Dave LaPoint | Steve Rosenberg | Dave LaPoint | Shawn Hillegas | 394 | 479 | -85 |
| 1989-07-19 | vs NYA | 94 | W 11-5 | 38-56 | 7 | 16,015 | Greg Hibbard | Clay Parker | Shawn Hillegas | Lee Guetterman | Bobby Thigpen | 405 | 484 | -79 |
| 1989-07-21 | @ BOS | 95 | W 1-0 | 39-56 | 7 | 34,925 | Melido Perez | Eric Hetzel | Melido Perez | Eric Hetzel | Bobby Thigpen | 406 | 484 | -78 |
| 1989-07-22 | @ BOS | 96 | W 10-6 | 40-56 | 7 | 34,899 | Richard Dotson | John Dopson | Ken Patterson | Rob Murphy | Donn Pall | 416 | 490 | -74 |
| 1989-07-23 | @ BOS | 97 | L 2-8 | 40-57 | 7 | 34,519 | Steve Rosenberg | Roger Clemens | Roger Clemens | Steve Rosenberg | | 418 | 498 | -80 |
| 1989-07-24 | vs SEA | 98 | W 5-4 | 41-57 | 7 | 11,430 | Jerry Reuss | Brian Holman | Shawn Hillegas | Michael Jackson | | 423 | 502 | -79 |
| 1989-07-25 | vs SEA | 99 | W 7-6 | 42-57 | 7 | 9,185 | Eric King | Scott Bankhead | Donn Pall | Michael Jackson | Bobby Thigpen | 430 | 508 | -78 |
| 1989-07-26 | vs SEA | 100 | W 5-3 | 43-57 | 7 | 14,430 | Greg Hibbard | Bill Swift | Greg Hibbard | Bill Swift | Bobby Thigpen | 435 | 511 | -76 |
| 1989-07-27 | @ CAL | 101 | L 5-8 | 43-58 | 7 | 31,892 | Melido Perez | Jim Abbott | Jim Abbott | Melido Perez | Bryan Harvey | 440 | 519 | -79 |
| 1989-07-28 | @ CAL | 102 | L 5-6 | 43-59 | 7 | 32,620 | Richard Dotson | Bert Blyleven | Bryan Harvey | Donn Pall | | 445 | 525 | -80 |
| 1989-07-29 | @ CAL | 103 | L 1-2 | 43-60 | 7 | 34,940 | Steve Rosenberg | Kirk McCaskill | Kirk McCaskill | Steve Rosenberg | Bryan Harvey | 446 | 527 | -81 |
| 1989-07-30 | @ CAL | 104 | W 3-2 | 44-60 | 7 | 29,363 | Jerry Reuss | Chuck Finley | Jerry Reuss | Chuck Finley | Bobby Thigpen | 449 | 529 | -80 |
| 1989-07-31 | @ OAK | 105 | L 2-3 | 44-61 | 7 | 34,554 | Eric King | Mike Moore | Mike Moore | Bobby Thigpen | | 451 | 532 | -81 |
| 1989-08-01 | @ OAK | 106 | L 0-2 | 44-62 | 7 | 22,536 | Greg Hibbard | Curt Young | Curt Young | Greg Hibbard | Dennis Eckersley | 451 | 534 | -83 |
| 1989-08-02 | @ OAK | 107 | L 0-2 | 44-63 | 7 | 25,146 | Melido Perez | Storm Davis | Storm Davis | Melido Perez | Rick Honeycutt | 451 | 536 | -85 |
| 1989-08-03 | @ OAK | 108 | W 6-4 | 45-63 | 7 | 31,974 | Richard Dotson | Bob Welch | Donn Pall | Bob Welch | Bobby Thigpen | 457 | 540 | -83 |
| 1989-08-04 | vs DET | 109 | W 5-4 | 46-63 | 7 | 16,918 | Steve Rosenberg | Jack Morris | Ken Patterson | Paul Gibson | | 462 | 544 | -82 |
| 1989-08-05 | vs DET | 110 | W 7-6 | 47-63 | 7 | 19,266 | Eric King | Doyle Alexander | Eric King | Doyle Alexander | Bobby Thigpen | 469 | 550 | -81 |
| 1989-08-06 | vs DET | 111 | L 3-4 | 47-64 | 7 | 14,418 | Greg Hibbard | Frank Tanana | Frank Tanana | Greg Hibbard | | 472 | 554 | -82 |
| 1989-08-08 | vs OAK | 112 | L 2-3 | 47-65 | 7 | 17,832 | Melido Perez | Dave Stewart | Rick Honeycutt | Donn Pall | Dennis Eckersley | 474 | 557 | -83 |
| 1989-08-09 | vs OAK | 113 | W 3-2 | 48-65 | 7 | 15,389 | Richard Dotson | Curt Young | Tom McCarthy | Jim Corsi | | 477 | 559 | -82 |
| 1989-08-10 | vs OAK | 114 | L 1-4 | 48-66 | 7 | 16,173 | Steve Rosenberg | Storm Davis | Storm Davis | Steve Rosenberg | Dennis Eckersley | 478 | 563 | -85 |
| 1989-08-11 | @ SEA | 115 | W 9-6 | 49-66 | 7 | 10,875 | Eric King | Mike Dunne | Bobby Thigpen | Mike Schooler | | 487 | 569 | -82 |
| 1989-08-12 | @ SEA | 116 | L 3-4 | 49-67 | 7 | 14,420 | Greg Hibbard | Clint Zavaras | Jerry Reed | Donn Pall | | 490 | 573 | -83 |
| 1989-08-13 | @ SEA | 117 | W 6-4 | 50-67 | 7 | 20,838 | Melido Perez | Randy Johnson | Bill Long | Keith Comstock | Bobby Thigpen | 496 | 577 | -81 |
| 1989-08-14 | vs KCA | 118 | W 4-3 | 51-67 | 7 | 10,575 | Richard Dotson | Luis Aquino | Ken Patterson | Luis Aquino | Bobby Thigpen | 500 | 580 | -80 |
| 1989-08-15 | vs KCA | 119 | L 6-10 | 51-68 | 7 | 13,553 | Steve Rosenberg | Charlie Leibrandt | Terry Leach | Tom McCarthy | | 506 | 590 | -84 |
| 1989-08-16 | vs KCA | 120 | L 4-5 | 51-69 | 7 | 11,155 | Eric King | Bret Saberhagen | Bret Saberhagen | Bobby Thigpen | Jeff Montgomery | 510 | 595 | -85 |
| 1989-08-17 | vs TEX | 121 | W 6-1 | 52-69 | 7 | 12,567 | Greg Hibbard | Kevin Brown | Greg Hibbard | Kevin Brown | | 516 | 596 | -80 |
| 1989-08-18 | vs TEX | 122 | L 5-6 | 52-70 | 7 | 12,723 | Melido Perez | Mike Jeffcoat | Mike Jeffcoat | Melido Perez | Jeff Russell | 521 | 602 | -81 |
| 1989-08-19 | vs TEX | 123 | L 6-7 | 52-71 | 7 | 18,638 | Richard Dotson | Bobby Witt | Bobby Witt | Richard Dotson | Jeff Russell | 527 | 609 | -82 |
| 1989-08-20 | vs TEX | 124 | L 1-7 | 52-72 | 7 | 27,158 | Steve Rosenberg | Charlie Hough | Charlie Hough | Steve Rosenberg | | 528 | 616 | -88 |
| 1989-08-22 | @ MIN | 125 | W 10-2 | 53-72 | 7 | 24,967 | Eric King | Shane Rawley | Eric King | Shane Rawley | | 538 | 618 | -80 |
| 1989-08-23 | @ MIN | 126 | L 7-8 | 53-73 | 7 | 21,726 | Greg Hibbard | Roy Smith | Roy Smith | Greg Hibbard | | 545 | 626 | -81 |
| 1989-08-24 | @ MIN | 127 | L 4-6 | 53-74 | 7 | 31,869 | Melido Perez | Rick Aguilera | Juan Berenguer | Shawn Hillegas | Jeff Reardon | 549 | 632 | -83 |
| 1989-08-25 | @ CLE | 128 | W 5-4 | 54-74 | 7 | 20,033 | Richard Dotson | Rod Nichols | Richard Dotson | Jesse Orosco | Bobby Thigpen | 554 | 636 | -82 |
| 1989-08-26 | @ CLE | 129 | W 4-3 | 55-74 | 7 | 14,469 | Steve Rosenberg | Buddy Black | Steve Rosenberg | Buddy Black | Bobby Thigpen | 558 | 639 | -81 |
| 1989-08-27 | @ CLE | 130 | W 9-3 | 56-74 | 7 | 24,835 | Greg Hibbard | John Farrell | Greg Hibbard | John Farrell | | 567 | 642 | -75 |
| 1989-08-29 | @ TOR | 131 | L 2-3 | 56-75 | 7 | 49,565 | Melido Perez | Mike Flanagan | Mike Flanagan | Donn Pall | Tom Henke | 569 | 645 | -76 |
| 1989-08-30 | @ TOR | 132 | L 1-2 | 56-76 | 7 | 49,435 | Richard Dotson | Jimmy Key | Jimmy Key | Richard Dotson | Duane Ward | 570 | 647 | -77 |
| 1989-08-31 | @ TOR | 133 | L 1-5 | 56-77 | 7 | 49,422 | Steve Rosenberg | Dave Stieb | Dave Stieb | Steve Rosenberg | | 571 | 652 | -81 |
| 1989-09-01 | vs BAL | 134 | W 10-1 | 57-77 | 7 | 11,574 | Eric King | Bob Milacki | Eric King | Bob Milacki | | 581 | 653 | -72 |
| 1989-09-02 | vs BAL | 135 | L 1-2 | 57-78 | 7 | 17,678 | Greg Hibbard | Pete Harnisch | Brian Holton | Greg Hibbard | Gregg Olson | 582 | 655 | -73 |
| 1989-09-03 | vs BAL | 136 | W 4-2 | 58-78 | 7 | 17,101 | Melido Perez | Jeff Ballard | Melido Perez | Jeff Ballard | Bobby Thigpen | 586 | 657 | -71 |
| 1989-09-04 | vs TOR | 137 | L 2-5 | 58-79 | 7 | 9,318 | Richard Dotson | Jimmy Key | Jimmy Key | Richard Dotson | Tom Henke | 588 | 662 | -74 |
| 1989-09-05 | vs TOR | 138 | L 1-6 | 58-80 | 7 | 7,858 | Steve Rosenberg | Dave Stieb | Dave Stieb | Steve Rosenberg | | 589 | 668 | -79 |
| 1989-09-06 | vs TOR | 139 | L 2-4 | 58-81 | 7 | 7,350 | Eric King | Todd Stottlemyre | Todd Stottlemyre | Eric King | Duane Ward | 591 | 672 | -81 |
| 1989-09-08 | @ DET | 140 | L 5-7 | 58-82 | 7 | 14,586 | Greg Hibbard | Jack Morris | Jack Morris | Greg Hibbard | Mike Henneman | 596 | 679 | -83 |
| 1989-09-09 | @ DET | 141 | W 13-3 | 59-82 | 7 | 18,791 | Melido Perez | Jeff Robinson | Melido Perez | Jeff Robinson | | 609 | 682 | -73 |
| 1989-09-10 | @ DET | 142 | L 5-6 | 59-83 | 7 | 15,597 | Richard Dotson | Doyle Alexander | Mike Henneman | Bobby Thigpen | | 614 | 688 | -74 |
| 1989-09-11 | @ BAL | 143 | L 3-6 | 59-84 | 7 | 21,581 | Steve Rosenberg | Jeff Ballard | Jeff Ballard | Steve Rosenberg | Gregg Olson | 617 | 694 | -77 |
| 1989-09-12 | @ BAL | 144 | W 11-1 | 60-84 | 7 | 19,629 | Eric King | Pete Harnisch | Eric King | Pete Harnisch | | 628 | 695 | -67 |
| 1989-09-13 | @ BAL | 145 | W 3-0 | 61-84 | 7 | 16,484 | Greg Hibbard | Dave Johnson | Greg Hibbard | Dave Johnson | Bobby Thigpen | 631 | 695 | -64 |
| 1989-09-15 | vs CAL | 146 | W 3-1 | 62-85 | 7 | 0 | Melido Perez | Jim Abbott | Melido Perez | Jim Abbott | | 634 | 696 | -62 |
| 1989-09-15 | vs CAL | 147 | L 1-2 | 62-85 | 7 | 11,202 | Richard Dotson | Chuck Finley | Chuck Finley | Richard Dotson | Bryan Harvey | 635 | 698 | -63 |
| 1989-09-16 | vs CAL | 148 | W 2-1 | 63-85 | 7 | 11,935 | Shawn Hillegas | Kirk McCaskill | Shawn Hillegas | Kirk McCaskill | Bobby Thigpen | 637 | 699 | -62 |
| 1989-09-17 | vs CAL | 149 | L 3-6 | 63-86 | 7 | 16,215 | Eric King | Mike Witt | Mike Witt | Eric King | Bryan Harvey | 640 | 705 | -65 |
| 1989-09-18 | @ KCA | 150 | W 4-2 | 64-86 | 7 | 23,722 | Greg Hibbard | Tom Gordon | Barry Jones | Jeff Montgomery | Bobby Thigpen | 644 | 707 | -63 |
| 1989-09-19 | @ KCA | 151 | L 3-5 | 64-87 | 7 | 19,748 | Richard Dotson | Larry McWilliams | Larry McWilliams | Richard Dotson | Steve Farr | 647 | 712 | -65 |
| 1989-09-20 | @ KCA | 152 | W 7-2 | 65-87 | 7 | 21,320 | Melido Perez | Mark Gubicza | Melido Perez | Mark Gubicza | | 654 | 714 | -60 |
| 1989-09-22 | @ TEX | 153 | W 9-6 | 66-87 | 7 | 15,655 | Shawn Hillegas | John Barfield | Barry Jones | Cecilio Guante | Bobby Thigpen | 663 | 720 | -57 |
| 1989-09-23 | @ TEX | 154 | L 4-6 | 66-88 | 7 | 22,570 | Eric King | Bobby Witt | Kenny Rogers | Jose Segura | Jeff Russell | 667 | 726 | -59 |
| 1989-09-24 | @ TEX | 155 | L 4-5 | 66-89 | 7 | 23,631 | Greg Hibbard | Nolan Ryan | Jeff Russell | Steve Rosenberg | | 671 | 731 | -60 |
| 1989-09-25 | vs MIN | 156 | W 10-2 | 67-89 | 7 | 6,975 | Richard Dotson | Mark Guthrie | Richard Dotson | Mark Guthrie | | 681 | 733 | -52 |
| 1989-09-26 | vs MIN | 157 | L 1-7 | 67-90 | 7 | 6,772 | Melido Perez | Rick Aguilera | Rick Aguilera | Melido Perez | | 682 | 740 | -58 |
| 1989-09-27 | vs MIN | 158 | L 1-6 | 67-91 | 7 | 8,004 | Shawn Hillegas | Mike Dyer | Mike Dyer | Shawn Hillegas | | 683 | 746 | -63 |
| 1989-09-29 | vs CLE | 159 | W 2-1 | 68-91 | 7 | 8,133 | Eric King | Tom Candiotti | Eric King | Tom Candiotti | Bobby Thigpen | 685 | 747 | -62 |
| 1989-09-30 | vs CLE | 160 | W 8-2 | 69-91 | 7 | 13,189 | Greg Hibbard | Rod Nichols | Greg Hibbard | Rod Nichols | Bill Long | 693 | 749 | -56 |
| 1989-10-01 | vs CLE | 161 | L 0-1 | 69-92 | 7 | 12,856 | Richard Dotson | Greg Swindell | Jesse Orosco | Richard Dotson | Doug Jones | 693 | 750 | -57 |