| 1989-04-03 | vs BOS | 1 | W 5-4 | 1-0 | 1 | 52,161 | Dave J. Schmidt | Roger Clemens | Brian Holton | Bob Stanley | | 5 | 4 | 1 |
| 1989-04-06 | vs BOS | 2 | W 6-4 | 2-0 | 1 | 22,041 | Jose Bautista | Mike Boddicker | Jose Bautista | Mike Smithson | Mark Williamson | 11 | 8 | 3 |
| 1989-04-07 | @ MIN | 3 | L 3-8 | 2-1 | 1 | 24,671 | Bob Milacki | Roy Smith | Roy Smith | Bob Milacki | | 14 | 16 | -2 |
| 1989-04-08 | @ MIN | 4 | L 5-6 | 2-2 | 2 | 35,969 | Dave J. Schmidt | Freddie Toliver | German Gonzalez | Brian Holton | Jeff Reardon | 19 | 22 | -3 |
| 1989-04-09 | @ MIN | 5 | W 8-1 | 3-2 | 2 | 42,307 | Jeff Ballard | Frank Viola | Jeff Ballard | Frank Viola | | 27 | 23 | 4 |
| 1989-04-10 | @ KCA | 6 | L 0-3 | 3-3 | 2 | 17,476 | Pete Harnisch | Bret Saberhagen | Bret Saberhagen | Pete Harnisch | | 27 | 26 | 1 |
| 1989-04-11 | @ KCA | 7 | L 5-6 | 3-4 | 3 | 17,623 | Jose Bautista | Floyd Bannister | Floyd Bannister | Jose Bautista | Steve Farr | 32 | 32 | 0 |
| 1989-04-12 | @ KCA | 8 | W 5-4 | 4-4 | 2 | 20,261 | Bob Milacki | Mark Gubicza | Gregg Olson | Steve Farr | | 37 | 36 | 1 |
| 1989-04-14 | @ BOS | 9 | L 4-7 | 4-5 | 3 | 24,460 | Dave J. Schmidt | John Dopson | John Dopson | Dave J. Schmidt | Bob Stanley | 41 | 43 | -2 |
| 1989-04-15 | @ BOS | 10 | W 12-4 | 5-5 | 1 | 28,457 | Jeff Ballard | Mike Boddicker | Jeff Ballard | Mike Boddicker | Gregg Olson | 53 | 47 | 6 |
| 1989-04-17 | @ BOS | 11 | L 4-6 | 5-6 | 3 | 32,923 | Jose Bautista | Wes Gardner | Lee Smith | Brian Holton | Bob Stanley | 57 | 53 | 4 |
| 1989-04-18 | vs KCA | 12 | L 4-7 | 5-7 | 5 | 13,408 | Bob Milacki | Mark Gubicza | Tom Gordon | Mark Williamson | Steve Farr | 61 | 60 | 1 |
| 1989-04-19 | vs KCA | 13 | W 6-5 | 6-7 | 2 | 15,354 | Dave J. Schmidt | Charlie Leibrandt | Dave J. Schmidt | Charlie Leibrandt | Mark Williamson | 67 | 65 | 2 |
| 1989-04-20 | vs KCA | 14 | W 2-0 | 7-7 | 2 | 22,925 | Jeff Ballard | Bret Saberhagen | Jeff Ballard | Bret Saberhagen | Mark Williamson | 69 | 65 | 4 |
| 1989-04-21 | vs MIN | 15 | L 1-7 | 7-8 | 3 | 24,807 | Jose Bautista | Allan Anderson | Allan Anderson | Jose Bautista | | 70 | 72 | -2 |
| 1989-04-22 | vs MIN | 16 | W 4-1 | 8-8 | 1 | 34,698 | Mark Thurmond | Freddie Toliver | Gregg Olson | Freddie Toliver | | 74 | 73 | 1 |
| 1989-04-23 | vs MIN | 17 | W 3-0 | 9-8 | 1 | 35,311 | Bob Milacki | Shane Rawley | Bob Milacki | Shane Rawley | | 77 | 73 | 4 |
| 1989-04-24 | @ CAL | 18 | L 2-3 | 9-9 | 1 | 22,213 | Dave J. Schmidt | Jim Abbott | Jim Abbott | Dave J. Schmidt | Bryan Harvey | 79 | 76 | 3 |
| 1989-04-25 | @ CAL | 19 | W 8-1 | 10-9 | 1 | 21,165 | Jeff Ballard | Mike Witt | Jeff Ballard | Mike Witt | | 87 | 77 | 10 |
| 1989-04-26 | @ OAK | 20 | W 2-1 | 11-9 | 1 | 17,060 | Jose Bautista | Bob Welch | Jose Bautista | Bob Welch | Gregg Olson | 89 | 78 | 11 |
| 1989-04-27 | @ OAK | 21 | L 4-9 | 11-10 | 2 | 21,423 | Pete Harnisch | Curt Young | Todd Burns | Mark Thurmond | | 93 | 87 | 6 |
| 1989-04-28 | @ SEA | 22 | L 5-11 | 11-11 | 1 | 10,929 | Bob Milacki | Erik Hanson | Jerry Reed | Brian Holton | | 98 | 98 | 0 |
| 1989-04-29 | @ SEA | 23 | L 3-4 | 11-12 | 1 | 14,688 | Dave J. Schmidt | Mark Langston | Mark Langston | Dave J. Schmidt | Mike Schooler | 101 | 102 | -1 |
| 1989-04-30 | @ SEA | 24 | W 4-3 | 12-12 | 1 | 9,452 | Jeff Ballard | Scott Bankhead | Jeff Ballard | Steve Trout | Mark Williamson | 105 | 105 | 0 |
| 1989-05-02 | vs CAL | 25 | W 4-3 | 13-12 | 1 | 17,668 | Jose Bautista | Chuck Finley | Gregg Olson | Willie Fraser | | 109 | 108 | 1 |
| 1989-05-03 | vs CAL | 26 | L 0-2 | 13-13 | 2 | 19,564 | Bob Milacki | Bert Blyleven | Rich Monteleone | Bob Milacki | | 109 | 110 | -1 |
| 1989-05-06 | vs SEA | 27 | L 1-2 | 13-15 | 4 | 0 | Dave J. Schmidt | Mark Langston | Mark Langston | Dave J. Schmidt | Mike Schooler | 110 | 112 | -2 |
| 1989-05-06 | vs SEA | 28 | L 5-6 | 13-15 | 4 | 19,975 | Jeff Ballard | Scott Bankhead | Scott Bankhead | Jeff Ballard | Mike Schooler | 115 | 118 | -3 |
| 1989-05-07 | vs SEA | 29 | L 3-5 | 13-16 | 5 | 25,982 | Jose Bautista | Bill Swift | Bill Swift | Jose Bautista | Dennis Powell | 118 | 123 | -5 |
| 1989-05-08 | vs OAK | 30 | L 1-6 | 13-17 | 5 | 19,159 | Bob Milacki | Mike Moore | Mike Moore | Bob Milacki | | 119 | 129 | -10 |
| 1989-05-11 | vs OAK | 31 | W 6-2 | 14-17 | 4 | 1,201 | Jeff Ballard | Dave Stewart | Jeff Ballard | Dave Stewart | | 125 | 131 | -6 |
| 1989-05-12 | vs CHA | 32 | W 9-6 | 15-17 | 3 | 20,484 | Dave J. Schmidt | Jerry Reuss | Mark Thurmond | Tom McCarthy | Kevin Hickey | 134 | 137 | -3 |
| 1989-05-13 | vs CHA | 33 | L 2-8 | 15-18 | 4 | 23,032 | Bob Milacki | Eric King | Eric King | Bob Milacki | | 136 | 145 | -9 |
| 1989-05-14 | vs CHA | 34 | L 5-8 | 15-19 | 4 | 35,124 | Jose Bautista | Shawn Hillegas | Steve Rosenberg | Mark Williamson | Bobby Thigpen | 141 | 153 | -12 |
| 1989-05-17 | @ TEX | 35 | W 8-2 | 16-19 | 4 | 12,558 | Dave J. Schmidt | Charlie Hough | Dave J. Schmidt | Charlie Hough | | 149 | 155 | -6 |
| 1989-05-18 | vs CLE | 36 | W 3-2 | 17-19 | 3 | 23,576 | Bob Milacki | Greg Swindell | Mark Williamson | Keith Atherton | | 152 | 157 | -5 |
| 1989-05-19 | vs CLE | 37 | L 1-4 | 17-20 | 4 | 21,933 | Jose Bautista | Tom Candiotti | Tom Candiotti | Jose Bautista | Doug Jones | 153 | 161 | -8 |
| 1989-05-20 | vs CLE | 38 | W 5-1 | 18-20 | 3 | 30,372 | Jeff Ballard | John Farrell | Jeff Ballard | John Farrell | | 158 | 162 | -4 |
| 1989-05-21 | vs CLE | 39 | L 0-2 | 18-21 | 4 | 35,428 | Brian Holton | Rich Yett | Rich Yett | Brian Holton | Doug Jones | 158 | 164 | -6 |
| 1989-05-22 | @ CHA | 40 | W 5-1 | 19-21 | 3 | 8,528 | Dave J. Schmidt | Steve Rosenberg | Dave J. Schmidt | Steve Rosenberg | | 163 | 165 | -2 |
| 1989-05-23 | @ CHA | 41 | W 9-3 | 20-21 | 2 | 9,251 | Bob Milacki | Bill Long | Bob Milacki | Bill Long | | 172 | 168 | 4 |
| 1989-05-24 | @ CHA | 42 | W 8-0 | 21-21 | 1 | 7,911 | Jay Tibbs | Eric King | Jay Tibbs | Eric King | Mark Williamson | 180 | 168 | 12 |
| 1989-05-26 | @ CLE | 43 | W 5-2 | 22-21 | 1 | 20,515 | Jeff Ballard | Rich Yett | Jeff Ballard | Rich Yett | Gregg Olson | 185 | 170 | 15 |
| 1989-05-27 | @ CLE | 44 | W 5-1 | 23-21 | 1 | 13,260 | Dave J. Schmidt | Buddy Black | Dave J. Schmidt | Buddy Black | Mark Huismann | 190 | 171 | 19 |
| 1989-05-28 | @ CLE | 45 | L 0-1 | 23-22 | 1 | 33,918 | Bob Milacki | Greg Swindell | Greg Swindell | Bob Milacki | | 190 | 172 | 18 |
| 1989-05-29 | vs TEX | 46 | W 6-1 | 24-22 | 1 | 32,263 | Brian Holton | Nolan Ryan | Brian Holton | Nolan Ryan | | 196 | 173 | 23 |
| 1989-05-30 | vs TEX | 47 | W 6-2 | 25-22 | 1 | 19,044 | Jay Tibbs | Jamie Moyer | Mark Williamson | Jamie Moyer | Gregg Olson | 202 | 175 | 27 |
| 1989-05-31 | vs TEX | 48 | W 8-5 | 26-22 | 1 | 25,236 | Jeff Ballard | Bobby Witt | Mark Williamson | Bobby Witt | Gregg Olson | 210 | 180 | 30 |
| 1989-06-01 | @ DET | 49 | W 8-3 | 27-22 | 1 | 14,861 | Dave J. Schmidt | Randy Nosek | Dave J. Schmidt | Randy Nosek | Mark Thurmond | 218 | 183 | 35 |
| 1989-06-02 | @ DET | 50 | W 4-1 | 28-22 | 1 | 19,758 | Bob Milacki | Mike Trujillo | Bob Milacki | Mike Trujillo | Kevin Hickey | 222 | 184 | 38 |
| 1989-06-03 | @ DET | 51 | W 4-2 | 29-22 | 1 | 19,738 | Brian Holton | Doyle Alexander | Kevin Hickey | Doyle Alexander | Gregg Olson | 226 | 186 | 40 |
| 1989-06-04 | @ DET | 52 | W 7-4 | 30-22 | 1 | 23,621 | Jay Tibbs | Frank Tanana | Jay Tibbs | Frank Tanana | Mark Williamson | 233 | 190 | 43 |
| 1989-06-05 | @ NYA | 53 | W 16-3 | 31-22 | 1 | 24,711 | Jeff Ballard | Andy Hawkins | Jeff Ballard | Andy Hawkins | | 249 | 193 | 56 |
| 1989-06-06 | @ NYA | 54 | L 0-4 | 31-23 | 1 | 24,260 | Dave J. Schmidt | Dave LaPoint | Dave LaPoint | Dave J. Schmidt | | 249 | 197 | 52 |
| 1989-06-08 | vs MIL | 55 | L 2-6 | 31-24 | 1 | 30,378 | Bob Milacki | Bill Krueger | Mark Knudson | Bob Milacki | | 251 | 203 | 48 |
| 1989-06-09 | vs MIL | 56 | W 7-1 | 32-24 | 1 | 31,156 | Brian Holton | Bryan Clutterbuck | Mark Williamson | Bryan Clutterbuck | | 258 | 204 | 54 |
| 1989-06-10 | vs MIL | 57 | L 0-6 | 32-25 | 1 | 44,294 | Jeff Ballard | Don August | Don August | Jeff Ballard | | 258 | 210 | 48 |
| 1989-06-11 | vs MIL | 58 | L 1-3 | 32-26 | 1 | 44,993 | Jay Tibbs | Teddy Higuera | Chuck Crim | Kevin Hickey | Dan Plesac | 259 | 213 | 46 |
| 1989-06-13 | vs NYA | 59 | W 5-2 | 33-26 | 1 | 24,674 | Dave J. Schmidt | Dave LaPoint | Dave J. Schmidt | Dave LaPoint | Gregg Olson | 264 | 215 | 49 |
| 1989-06-14 | vs NYA | 60 | L 1-2 | 33-27 | 1 | 28,626 | Bob Milacki | Chuck Cary | Lee Guetterman | Kevin Hickey | Dave Righetti | 265 | 217 | 48 |
| 1989-06-15 | vs NYA | 61 | W 3-2 | 34-27 | 1 | 30,284 | Jeff Ballard | Richard Dotson | Mark Thurmond | Lance McCullers | | 268 | 219 | 49 |
| 1989-06-16 | vs OAK | 62 | L 5-7 | 35-28 | 1 | 0 | Brian Holton | Storm Davis | Storm Davis | Brian Holton | Rick Honeycutt | 273 | 226 | 47 |
| 1989-06-16 | vs OAK | 63 | W 5-1 | 35-28 | 1 | 40,707 | Jay Tibbs | Mike Moore | Jay Tibbs | Mike Moore | | 278 | 227 | 51 |
| 1989-06-17 | vs OAK | 64 | W 4-2 | 36-28 | 1 | 36,431 | Jose Bautista | Matt Young | Jose Bautista | Matt Young | Gregg Olson | 282 | 229 | 53 |
| 1989-06-18 | vs OAK | 65 | W 4-2 | 37-28 | 1 | 46,541 | Dave J. Schmidt | Curt Young | Dave J. Schmidt | Curt Young | Mickey Weston | 286 | 231 | 55 |
| 1989-06-19 | @ SEA | 66 | W 9-5 | 38-28 | 1 | 17,623 | Bob Milacki | Bill Swift | Bob Milacki | Michael Jackson | Mark Thurmond | 295 | 236 | 59 |
| 1989-06-20 | @ SEA | 67 | W 8-6 | 39-28 | 1 | 10,547 | Jeff Ballard | Randy Johnson | Mickey Weston | Jerry Reed | Gregg Olson | 303 | 242 | 61 |
| 1989-06-21 | @ SEA | 68 | W 8-6 | 40-28 | 1 | 11,225 | Jay Tibbs | Brian Holman | Jay Tibbs | Brian Holman | Gregg Olson | 311 | 248 | 63 |
| 1989-06-22 | @ CAL | 69 | W 6-5 | 41-28 | 1 | 23,876 | Brian Holton | Jim Abbott | Mark Williamson | Willie Fraser | Gregg Olson | 317 | 253 | 64 |
| 1989-06-23 | @ CAL | 70 | L 1-5 | 41-29 | 1 | 45,452 | Dave J. Schmidt | Mike Witt | Mike Witt | Dave J. Schmidt | | 318 | 258 | 60 |
| 1989-06-24 | @ CAL | 71 | L 3-8 | 41-30 | 1 | 45,824 | Bob Milacki | Chuck Finley | Chuck Finley | Bob Milacki | | 321 | 266 | 55 |
| 1989-06-25 | @ CAL | 72 | L 6-7 | 41-31 | 1 | 37,528 | Jeff Ballard | Kirk McCaskill | Kirk McCaskill | Jeff Ballard | Bryan Harvey | 327 | 273 | 54 |
| 1989-06-27 | vs TOR | 73 | W 16-6 | 42-31 | 1 | 30,136 | Jay Tibbs | Mike Flanagan | Jay Tibbs | Mike Flanagan | | 343 | 279 | 64 |
| 1989-06-28 | vs TOR | 74 | W 2-1 | 43-31 | 1 | 35,757 | Brian Holton | John Cerutti | Kevin Hickey | John Cerutti | Gregg Olson | 345 | 280 | 65 |
| 1989-06-29 | vs TOR | 75 | L 1-11 | 43-32 | 1 | 39,528 | Dave J. Schmidt | Steve Cummings | Steve Cummings | Dave J. Schmidt | | 346 | 291 | 55 |
| 1989-06-30 | vs DET | 76 | L 5-16 | 43-33 | 1 | 40,594 | Bob Milacki | David Palmer | Mike Schwabe | Bob Milacki | | 351 | 307 | 44 |
| 1989-07-01 | vs DET | 77 | W 8-1 | 44-33 | 1 | 39,943 | Jeff Ballard | Charles Hudson | Jeff Ballard | Charles Hudson | | 359 | 308 | 51 |
| 1989-07-02 | vs DET | 78 | L 3-7 | 44-34 | 1 | 39,609 | Jay Tibbs | Paul Gibson | Ed Nunez | Mark Thurmond | Mike Henneman | 362 | 315 | 47 |
| 1989-07-03 | vs DET | 79 | W 11-4 | 45-34 | 1 | 35,656 | Brian Holton | Doyle Alexander | Mike Smith | Doyle Alexander | | 373 | 319 | 54 |
| 1989-07-04 | @ TOR | 80 | W 8-0 | 46-34 | 1 | 44,025 | Dave J. Schmidt | Dave Stieb | Dave J. Schmidt | Dave Stieb | Mark Williamson | 381 | 319 | 62 |
| 1989-07-05 | @ TOR | 81 | W 5-4 | 47-34 | 1 | 49,239 | Bob Milacki | Jimmy Key | Bob Milacki | Jimmy Key | Gregg Olson | 386 | 323 | 63 |
| 1989-07-06 | @ TOR | 82 | L 1-4 | 47-35 | 1 | 46,629 | Jeff Ballard | Todd Stottlemyre | Todd Stottlemyre | Jeff Ballard | Duane Ward | 387 | 327 | 60 |
| 1989-07-07 | @ MIL | 83 | L 4-6 | 47-36 | 1 | 27,313 | Pete Harnisch | Don August | Don August | Pete Harnisch | Dan Plesac | 391 | 333 | 58 |
| 1989-07-08 | @ MIL | 84 | W 5-2 | 48-36 | 1 | 42,237 | Brian Holton | Teddy Higuera | Brian Holton | Teddy Higuera | Gregg Olson | 396 | 335 | 61 |
| 1989-07-09 | @ MIL | 85 | L 2-7 | 48-37 | 1 | 39,328 | Dave J. Schmidt | Chris Bosio | Chris Bosio | Dave J. Schmidt | | 398 | 342 | 56 |
| 1989-07-13 | vs CAL | 86 | L 5-13 | 48-38 | 1 | 29,750 | Jeff Ballard | Bert Blyleven | Bert Blyleven | Mark Thurmond | | 403 | 355 | 48 |
| 1989-07-14 | vs CAL | 87 | W 6-4 | 49-38 | 1 | 45,921 | Brian Holton | Kirk McCaskill | Brian Holton | Kirk McCaskill | Gregg Olson | 409 | 359 | 50 |
| 1989-07-15 | vs CAL | 88 | W 11-9 | 50-38 | 1 | 47,393 | Dave J. Schmidt | Chuck Finley | Mark Williamson | Bryan Harvey | | 420 | 368 | 52 |
| 1989-07-16 | vs CAL | 89 | W 3-2 | 51-38 | 1 | 40,526 | Bob Milacki | Mike Witt | Mike Smith | Willie Fraser | | 423 | 370 | 53 |
| 1989-07-17 | vs SEA | 90 | W 8-4 | 52-38 | 1 | 36,129 | Pete Harnisch | Mike Dunne | Pete Harnisch | Mike Dunne | | 431 | 374 | 57 |
| 1989-07-18 | vs SEA | 91 | W 4-3 | 53-38 | 1 | 29,705 | Jeff Ballard | Randy Johnson | Jeff Ballard | Randy Johnson | Gregg Olson | 435 | 377 | 58 |
| 1989-07-19 | vs SEA | 92 | L 0-7 | 53-39 | 1 | 35,691 | Brian Holton | Brian Holman | Brian Holman | Brian Holton | | 435 | 384 | 51 |
| 1989-07-20 | @ OAK | 93 | L 2-5 | 53-40 | 1 | 30,697 | Dave J. Schmidt | Dave Stewart | Dave Stewart | Dave J. Schmidt | Dennis Eckersley | 437 | 389 | 48 |
| 1989-07-21 | @ OAK | 94 | L 2-3 | 53-41 | 1 | 30,848 | Bob Milacki | Mike Moore | Mike Moore | Gregg Olson | | 439 | 392 | 47 |
| 1989-07-22 | @ OAK | 95 | L 1-3 | 53-42 | 1 | 37,241 | Pete Harnisch | Bob Welch | Bob Welch | Pete Harnisch | Dennis Eckersley | 440 | 395 | 45 |
| 1989-07-23 | @ OAK | 96 | L 2-3 | 53-43 | 1 | 43,570 | Jeff Ballard | Storm Davis | Storm Davis | Jeff Ballard | Dennis Eckersley | 442 | 398 | 44 |
| 1989-07-25 | @ MIN | 97 | L 3-9 | 53-44 | 1 | 26,626 | Dave J. Schmidt | Allan Anderson | Allan Anderson | Dave J. Schmidt | | 445 | 407 | 38 |
| 1989-07-26 | @ MIN | 98 | L 4-5 | 53-45 | 1 | 28,321 | Bob Milacki | Shane Rawley | Jeff Reardon | Mark Williamson | | 449 | 412 | 37 |
| 1989-07-27 | @ MIN | 99 | L 6-10 | 53-46 | 1 | 27,642 | Pete Harnisch | Roy Smith | Roy Smith | Pete Harnisch | | 455 | 422 | 33 |
| 1989-07-28 | @ KCA | 100 | W 4-3 | 54-46 | 1 | 38,606 | Jeff Ballard | Mark Gubicza | Mark Williamson | Jeff Montgomery | | 459 | 425 | 34 |
| 1989-07-29 | @ KCA | 101 | L 0-5 | 54-47 | 1 | 40,053 | Dave J. Schmidt | Luis Aquino | Luis Aquino | Dave J. Schmidt | | 459 | 430 | 29 |
| 1989-07-30 | @ KCA | 102 | L 6-7 | 54-48 | 1 | 30,208 | Mike Smith | Charlie Leibrandt | Steve Farr | Gregg Olson | Jeff Montgomery | 465 | 437 | 28 |
| 1989-07-31 | @ BOS | 103 | L 6-9 | 54-49 | 1 | 33,826 | Bob Milacki | Eric Hetzel | Bob Stanley | Bob Milacki | Lee Smith | 471 | 446 | 25 |
| 1989-08-01 | @ BOS | 104 | L 3-5 | 54-51 | 1 | 35,111 | Pete Harnisch | John Dopson | Rob Murphy | Pete Harnisch | Lee Smith | 474 | 451 | 23 |
| 1989-08-01 | @ BOS | 105 | L 2-6 | 54-51 | 1 | 34,901 | Dave Johnson | Wes Gardner | Wes Gardner | Dave Johnson | | 476 | 457 | 19 |
| 1989-08-02 | @ BOS | 106 | W 9-8 | 55-51 | 1 | 34,970 | Jeff Ballard | Joe Price | Mark Williamson | Eric Hetzel | Mark Thurmond | 485 | 465 | 20 |
| 1989-08-04 | vs TEX | 107 | L 4-6 | 55-52 | 1 | 37,754 | Dave J. Schmidt | Charlie Hough | Charlie Hough | Dave J. Schmidt | Jeff Russell | 489 | 471 | 18 |
| 1989-08-05 | vs TEX | 108 | W 5-2 | 56-52 | 1 | 48,776 | Bob Milacki | Nolan Ryan | Bob Milacki | Nolan Ryan | Gregg Olson | 494 | 473 | 21 |
| 1989-08-06 | vs TEX | 109 | W 3-2 | 57-52 | 1 | 28,592 | Pete Harnisch | Kevin Brown | Mark Williamson | Jeff Russell | | 497 | 475 | 22 |
| 1989-08-07 | vs MIN | 110 | L 2-4 | 57-53 | 1 | 36,180 | Jeff Ballard | Roy Smith | Roy Smith | Jeff Ballard | Jeff Reardon | 499 | 479 | 20 |
| 1989-08-08 | vs MIN | 111 | W 6-1 | 58-53 | 1 | 27,875 | Dave Johnson | Rick Aguilera | Dave Johnson | Rick Aguilera | | 505 | 480 | 25 |
| 1989-08-09 | vs MIN | 112 | L 0-7 | 58-54 | 1 | 30,132 | Mark Thurmond | Allan Anderson | Allan Anderson | Mark Thurmond | | 505 | 487 | 18 |
| 1989-08-11 | vs BOS | 113 | L 4-6 | 59-55 | 1 | 0 | Bob Milacki | Roger Clemens | Roger Clemens | Bob Milacki | | 509 | 493 | 16 |
| 1989-08-11 | vs BOS | 114 | W 4-1 | 59-55 | 1 | 49,003 | Pete Harnisch | Mike Smithson | Pete Harnisch | Mike Smithson | | 513 | 494 | 19 |
| 1989-08-12 | vs BOS | 115 | L 8-10 | 59-56 | 1 | 50,865 | Jeff Ballard | Wes Gardner | Bob Stanley | Kevin Hickey | | 521 | 504 | 17 |
| 1989-08-13 | vs BOS | 116 | W 6-1 | 60-56 | 1 | 46,335 | Dave Johnson | Tom Bolton | Dave Johnson | Tom Bolton | | 527 | 505 | 22 |
| 1989-08-14 | @ DET | 117 | W 4-1 | 61-56 | 1 | 17,447 | Brian Holton | Jack Morris | Dave J. Schmidt | Jack Morris | Gregg Olson | 531 | 506 | 25 |
| 1989-08-15 | @ DET | 118 | W 2-0 | 62-56 | 1 | 16,203 | Bob Milacki | Doyle Alexander | Bob Milacki | Doyle Alexander | | 533 | 506 | 27 |
| 1989-08-16 | @ DET | 119 | L 0-4 | 62-57 | 1 | 17,092 | Pete Harnisch | Frank Tanana | Frank Tanana | Pete Harnisch | | 533 | 510 | 23 |
| 1989-08-17 | vs TOR | 120 | W 11-6 | 63-57 | 1 | 40,147 | Jeff Ballard | John Cerutti | Jeff Ballard | John Cerutti | | 544 | 516 | 28 |
| 1989-08-18 | vs TOR | 121 | L 2-9 | 63-58 | 1 | 31,668 | Dave Johnson | Mauro Gozzo | Mauro Gozzo | Dave Johnson | | 546 | 525 | 21 |
| 1989-08-19 | vs TOR | 122 | L 1-5 | 63-59 | 1 | 38,111 | Bob Milacki | Jimmy Key | Jimmy Key | Bob Milacki | | 547 | 530 | 17 |
| 1989-08-20 | vs TOR | 123 | W 7-2 | 64-59 | 1 | 37,242 | Pete Harnisch | Dave Stieb | Pete Harnisch | Dave Stieb | Mark Thurmond | 554 | 532 | 22 |
| 1989-08-21 | vs MIL | 124 | W 5-0 | 65-59 | 1 | 31,912 | Jeff Ballard | Jerry Reuss | Jeff Ballard | Jerry Reuss | | 559 | 532 | 27 |
| 1989-08-22 | vs MIL | 125 | W 4-2 | 66-59 | 1 | 31,726 | Dave Johnson | Chris Bosio | Dave Johnson | Chris Bosio | | 563 | 534 | 29 |
| 1989-08-23 | vs MIL | 126 | W 3-1 | 67-59 | 1 | 32,702 | Bob Milacki | Tom Filer | Bob Milacki | Tom Filer | Gregg Olson | 566 | 535 | 31 |
| 1989-08-24 | @ NYA | 127 | L 1-5 | 68-60 | 1 | 0 | Pete Harnisch | Chuck Cary | Chuck Cary | Pete Harnisch | | 567 | 540 | 27 |
| 1989-08-24 | @ NYA | 128 | W 9-2 | 68-60 | 1 | 30,214 | Dave J. Schmidt | Eric Plunk | Dave J. Schmidt | Eric Plunk | | 576 | 542 | 34 |
| 1989-08-25 | @ NYA | 129 | W 3-1 | 69-60 | 1 | 30,177 | Jeff Ballard | Clay Parker | Jeff Ballard | Clay Parker | Gregg Olson | 579 | 543 | 36 |
| 1989-08-26 | @ NYA | 130 | W 6-4 | 70-60 | 1 | 38,021 | Dave Johnson | Walt Terrell | Dave Johnson | Walt Terrell | Gregg Olson | 585 | 547 | 38 |
| 1989-08-27 | @ NYA | 131 | W 8-5 | 71-60 | 1 | 43,799 | Bob Milacki | Greg Cadaret | Bob Milacki | Greg Cadaret | | 593 | 552 | 41 |
| 1989-08-29 | @ CLE | 132 | L 1-3 | 71-61 | 1 | 10,035 | Pete Harnisch | Tom Candiotti | Doug Jones | Pete Harnisch | | 594 | 555 | 39 |
| 1989-08-30 | @ CLE | 133 | W 7-4 | 72-61 | 1 | 13,020 | Jeff Ballard | Greg Swindell | Jeff Ballard | Greg Swindell | Gregg Olson | 601 | 559 | 42 |
| 1989-08-31 | @ CLE | 134 | L 0-11 | 72-62 | 1 | 9,735 | Dave Johnson | John Farrell | John Farrell | Dave Johnson | | 601 | 570 | 31 |
| 1989-09-01 | @ CHA | 135 | L 1-10 | 72-63 | 2 | 11,574 | Bob Milacki | Eric King | Eric King | Bob Milacki | | 602 | 580 | 22 |
| 1989-09-02 | @ CHA | 136 | W 2-1 | 73-63 | 2 | 17,678 | Pete Harnisch | Greg Hibbard | Brian Holton | Greg Hibbard | Gregg Olson | 604 | 581 | 23 |
| 1989-09-03 | @ CHA | 137 | L 2-4 | 73-64 | 2 | 17,101 | Jeff Ballard | Melido Perez | Melido Perez | Jeff Ballard | Bobby Thigpen | 606 | 585 | 21 |
| 1989-09-04 | vs CLE | 138 | W 5-4 | 74-64 | 2 | 32,875 | Dave Johnson | Greg Swindell | Mark Williamson | Rod Nichols | | 611 | 589 | 22 |
| 1989-09-05 | vs CLE | 139 | W 3-1 | 75-64 | 2 | 19,985 | Bob Milacki | John Farrell | Bob Milacki | John Farrell | Gregg Olson | 614 | 590 | 24 |
| 1989-09-06 | vs CLE | 140 | L 0-9 | 75-65 | 2 | 29,405 | Curt Schilling | Buddy Black | Buddy Black | Curt Schilling | | 614 | 599 | 15 |
| 1989-09-07 | @ TEX | 141 | W 8-3 | 77-65 | 2 | 0 | Jeff Ballard | Nolan Ryan | Jeff Ballard | Nolan Ryan | Mark Williamson | 622 | 602 | 20 |
| 1989-09-07 | @ TEX | 142 | W 9-6 | 77-65 | 2 | 15,759 | Pete Harnisch | Bobby Witt | Pete Harnisch | Bobby Witt | | 631 | 608 | 23 |
| 1989-09-08 | @ TEX | 143 | L 1-3 | 77-66 | 2 | 15,080 | Dave Johnson | Kevin Brown | Kevin Brown | Dave Johnson | Jeff Russell | 632 | 611 | 21 |
| 1989-09-09 | @ TEX | 144 | W 4-2 | 78-66 | 2 | 30,332 | Bob Milacki | Mike Jeffcoat | Gregg Olson | Drew Hall | | 636 | 613 | 23 |
| 1989-09-10 | @ TEX | 145 | L 1-8 | 78-67 | 2 | 13,783 | Dave J. Schmidt | Jamie Moyer | Jamie Moyer | Dave J. Schmidt | | 637 | 621 | 16 |
| 1989-09-11 | vs CHA | 146 | W 6-3 | 79-67 | 2 | 21,581 | Jeff Ballard | Steve Rosenberg | Jeff Ballard | Steve Rosenberg | Gregg Olson | 643 | 624 | 19 |
| 1989-09-12 | vs CHA | 147 | L 1-11 | 79-68 | 2 | 19,629 | Pete Harnisch | Eric King | Eric King | Pete Harnisch | | 644 | 635 | 9 |
| 1989-09-13 | vs CHA | 148 | L 0-3 | 79-69 | 2 | 16,484 | Dave Johnson | Greg Hibbard | Greg Hibbard | Dave Johnson | Bobby Thigpen | 644 | 638 | 6 |
| 1989-09-15 | vs KCA | 149 | W 5-2 | 80-69 | 2 | 38,029 | Bob Milacki | Larry McWilliams | Bob Milacki | Steve Crawford | Gregg Olson | 649 | 640 | 9 |
| 1989-09-16 | vs KCA | 150 | W 7-5 | 81-69 | 2 | 44,591 | Jeff Ballard | Mark Gubicza | Gregg Olson | Terry Leach | | 656 | 645 | 11 |
| 1989-09-17 | vs KCA | 151 | L 0-7 | 81-70 | 2 | 42,254 | Dave Johnson | Bret Saberhagen | Bret Saberhagen | Dave Johnson | | 656 | 652 | 4 |
| 1989-09-19 | vs DET | 152 | W 6-2 | 82-70 | 2 | 22,378 | Bob Milacki | Jack Morris | Bob Milacki | Jack Morris | Mark Williamson | 662 | 654 | 8 |
| 1989-09-20 | vs DET | 153 | W 9-2 | 83-70 | 2 | 30,644 | Jeff Ballard | Frank Tanana | Jeff Ballard | Frank Tanana | | 671 | 656 | 15 |
| 1989-09-22 | vs NYA | 154 | L 4-5 | 83-71 | 2 | 47,721 | Dave Johnson | Walt Terrell | Walt Terrell | Brian Holton | Dave Righetti | 675 | 661 | 14 |
| 1989-09-23 | vs NYA | 155 | W 10-2 | 84-71 | 2 | 48,308 | Bob Milacki | Eric Plunk | Bob Milacki | Eric Plunk | | 685 | 663 | 22 |
| 1989-09-24 | vs NYA | 156 | L 0-2 | 84-72 | 2 | 51,173 | Jeff Ballard | Chuck Cary | Chuck Cary | Jeff Ballard | Dave Righetti | 685 | 665 | 20 |
| 1989-09-25 | @ MIL | 157 | W 5-3 | 85-72 | 2 | 12,284 | Pete Harnisch | Teddy Higuera | Pete Harnisch | Teddy Higuera | Gregg Olson | 690 | 668 | 22 |
| 1989-09-26 | @ MIL | 158 | L 3-7 | 85-73 | 2 | 12,814 | Dave Johnson | Jaime Navarro | Jaime Navarro | Dave Johnson | | 693 | 675 | 18 |
| 1989-09-27 | @ MIL | 159 | W 4-0 | 86-73 | 2 | 14,463 | Bob Milacki | Jerry Reuss | Bob Milacki | Jerry Reuss | | 697 | 675 | 22 |
| 1989-09-29 | @ TOR | 160 | L 1-2 | 86-74 | 2 | 49,636 | Jeff Ballard | Todd Stottlemyre | Tom Henke | Mark Williamson | | 698 | 677 | 21 |
| 1989-09-30 | @ TOR | 161 | L 3-4 | 86-75 | 2 | 49,553 | Dave Johnson | Jimmy Key | Frank Wills | Mark Williamson | Tom Henke | 701 | 681 | 20 |
| 1989-10-01 | @ TOR | 162 | W 7-5 | 87-75 | 2 | 49,469 | Bob Milacki | Jose Nunez | Ben McDonald | Mauro Gozzo | | 708 | 686 | 22 |