| 1989-04-03 | vs SEA | 1 | W 3-2 | 1-0 | 1 | 46,163 | Dave Stewart | Mark Langston | Dave Stewart | Mark Langston | Dennis Eckersley | 3 | 2 | 1 |
| 1989-04-05 | vs SEA | 2 | W 11-1 | 2-0 | 1 | 16,045 | Bob Welch | Scott Bankhead | Bob Welch | Scott Bankhead | | 14 | 3 | 11 |
| 1989-04-06 | vs SEA | 3 | W 11-3 | 3-0 | 1 | 19,087 | Storm Davis | Mike Campbell | Storm Davis | Mike Campbell | Todd Burns | 25 | 6 | 19 |
| 1989-04-07 | vs CHA | 4 | L 1-7 | 3-1 | 4 | 20,585 | Curt Young | Bill Long | Bill Long | Curt Young | Barry Jones | 26 | 13 | 13 |
| 1989-04-08 | vs CHA | 5 | L 4-7 | 3-2 | 5 | 32,881 | Mike Moore | Melido Perez | Melido Perez | Mike Moore | Bobby Thigpen | 30 | 20 | 10 |
| 1989-04-09 | vs CHA | 6 | W 4-2 | 4-2 | 5 | 45,110 | Dave Stewart | Jerry Reuss | Dave Stewart | Jerry Reuss | Dennis Eckersley | 34 | 22 | 12 |
| 1989-04-10 | @ CAL | 7 | W 4-0 | 5-2 | 3 | 23,820 | Bob Welch | Chuck Finley | Bob Welch | Chuck Finley | | 38 | 22 | 16 |
| 1989-04-11 | @ CAL | 8 | L 1-7 | 5-3 | 5 | 23,322 | Storm Davis | Bert Blyleven | Bert Blyleven | Storm Davis | | 39 | 29 | 10 |
| 1989-04-12 | @ CAL | 9 | L 0-5 | 5-4 | 5 | 24,650 | Curt Young | Kirk McCaskill | Kirk McCaskill | Curt Young | | 39 | 34 | 5 |
| 1989-04-13 | @ CAL | 10 | W 5-0 | 6-4 | 4 | 24,137 | Mike Moore | Jim Abbott | Mike Moore | Jim Abbott | | 44 | 34 | 10 |
| 1989-04-14 | @ CHA | 11 | W 7-4 | 7-4 | 2 | 37,950 | Dave Stewart | Melido Perez | Dave Stewart | Melido Perez | | 51 | 38 | 13 |
| 1989-04-15 | @ CHA | 12 | L 4-7 | 7-5 | 3 | 15,748 | Bob Welch | Jerry Reuss | Jerry Reuss | Bob Welch | Bobby Thigpen | 55 | 45 | 10 |
| 1989-04-16 | @ CHA | 13 | W 3-2 | 8-5 | 2 | 20,969 | Storm Davis | Eric King | Dennis Eckersley | Eric King | | 58 | 47 | 11 |
| 1989-04-17 | @ SEA | 14 | L 2-7 | 8-6 | 4 | 14,827 | Curt Young | Erik Hanson | Erik Hanson | Curt Young | | 60 | 54 | 6 |
| 1989-04-18 | @ SEA | 15 | W 5-3 | 9-6 | 4 | 9,670 | Mike Moore | Steve Trout | Eric Plunk | Jerry Reed | Dennis Eckersley | 65 | 57 | 8 |
| 1989-04-19 | @ SEA | 16 | W 7-5 | 10-6 | 2 | 11,328 | Dave Stewart | Mark Langston | Dave Stewart | Mark Langston | Dennis Eckersley | 72 | 62 | 10 |
| 1989-04-21 | vs CAL | 17 | W 10-6 | 11-6 | 2 | 26,903 | Bob Welch | Chuck Finley | Bob Welch | Chuck Finley | Rick Honeycutt | 82 | 68 | 14 |
| 1989-04-22 | vs CAL | 18 | W 4-3 | 12-6 | 2 | 33,172 | Curt Young | Bert Blyleven | Curt Young | Bert Blyleven | Dennis Eckersley | 86 | 71 | 15 |
| 1989-04-23 | vs CAL | 19 | W 2-0 | 13-6 | 2 | 25,681 | Mike Moore | Kirk McCaskill | Mike Moore | Kirk McCaskill | Dennis Eckersley | 88 | 71 | 17 |
| 1989-04-24 | vs TOR | 20 | W 5-4 | 14-6 | 2 | 25,099 | Dave Stewart | Jimmy Key | Gene Nelson | Tom Henke | | 93 | 75 | 18 |
| 1989-04-25 | vs TOR | 21 | W 3-1 | 15-6 | 2 | 12,437 | Storm Davis | John Cerutti | Storm Davis | John Cerutti | Dennis Eckersley | 96 | 76 | 20 |
| 1989-04-26 | vs BAL | 22 | L 1-2 | 15-7 | 2 | 17,060 | Bob Welch | Jose Bautista | Jose Bautista | Bob Welch | Gregg Olson | 97 | 78 | 19 |
| 1989-04-27 | vs BAL | 23 | W 9-4 | 16-7 | 2 | 21,423 | Curt Young | Pete Harnisch | Todd Burns | Mark Thurmond | | 106 | 82 | 24 |
| 1989-04-28 | vs DET | 24 | W 2-1 | 17-7 | 2 | 26,594 | Mike Moore | Paul Gibson | Mike Moore | Paul Gibson | Dennis Eckersley | 108 | 83 | 25 |
| 1989-04-29 | vs DET | 25 | W 3-2 | 18-7 | 2 | 36,313 | Dave Stewart | Doyle Alexander | Dave Stewart | Doyle Alexander | | 111 | 85 | 26 |
| 1989-04-30 | vs DET | 26 | L 2-7 | 18-8 | 2 | 36,009 | Storm Davis | Frank Tanana | Frank Tanana | Storm Davis | Guillermo Hernandez | 113 | 92 | 21 |
| 1989-05-02 | @ TOR | 27 | W 8-5 | 19-8 | 2 | 23,439 | Bob Welch | Dave Stieb | Rick Honeycutt | Duane Ward | Eric Plunk | 121 | 97 | 24 |
| 1989-05-03 | @ TOR | 28 | L 0-2 | 19-9 | 2 | 22,370 | Mike Moore | Mike Flanagan | Mike Flanagan | Mike Moore | | 121 | 99 | 22 |
| 1989-05-05 | @ DET | 29 | W 5-3 | 20-9 | 1 | 18,482 | Dave Stewart | Frank Tanana | Dave Stewart | Frank Tanana | Dennis Eckersley | 126 | 102 | 24 |
| 1989-05-06 | @ DET | 30 | L 3-6 | 20-10 | 1 | 32,404 | Storm Davis | Jack Morris | Jack Morris | Storm Davis | Guillermo Hernandez | 129 | 108 | 21 |
| 1989-05-07 | @ DET | 31 | W 5-4 | 21-10 | 1 | 20,391 | Bob Welch | Jeff Robinson | Bob Welch | Charles Hudson | Dennis Eckersley | 134 | 112 | 22 |
| 1989-05-08 | @ BAL | 32 | W 6-1 | 22-10 | 1 | 19,159 | Mike Moore | Bob Milacki | Mike Moore | Bob Milacki | | 140 | 113 | 27 |
| 1989-05-11 | @ BAL | 33 | L 2-6 | 22-11 | 1 | 1,201 | Dave Stewart | Jeff Ballard | Jeff Ballard | Dave Stewart | | 142 | 119 | 23 |
| 1989-05-12 | vs MIL | 34 | W 5-4 | 23-11 | 1 | 30,743 | Storm Davis | Mike Birkbeck | Todd Burns | Dan Plesac | | 147 | 123 | 24 |
| 1989-05-13 | vs MIL | 35 | W 4-3 | 24-11 | 1 | 33,053 | Bob Welch | Chris Bosio | Bob Welch | Chris Bosio | Dennis Eckersley | 151 | 126 | 25 |
| 1989-05-14 | vs MIL | 36 | L 1-2 | 24-12 | 1 | 26,989 | Mike Moore | Bryan Clutterbuck | Chuck Crim | Mike Moore | Dan Plesac | 152 | 128 | 24 |
| 1989-05-15 | vs MIL | 37 | W 12-2 | 25-12 | 1 | 25,974 | Dave Stewart | Don August | Dave Stewart | Don August | | 164 | 130 | 34 |
| 1989-05-16 | vs NYA | 38 | L 2-3 | 25-13 | 2 | 25,852 | Curt Young | Clay Parker | Clay Parker | Curt Young | Dave Righetti | 166 | 133 | 33 |
| 1989-05-17 | vs NYA | 39 | W 8-3 | 26-13 | 1 | 24,505 | Storm Davis | Richard Dotson | Storm Davis | Richard Dotson | Dennis Eckersley | 174 | 136 | 38 |
| 1989-05-18 | vs NYA | 40 | W 6-2 | 27-13 | 1 | 40,758 | Bob Welch | Tommy John | Bob Welch | Tommy John | Todd Burns | 180 | 138 | 42 |
| 1989-05-19 | vs BOS | 41 | L 4-7 | 27-14 | 1 | 40,382 | Mike Moore | Mike Boddicker | Bob Stanley | Gene Nelson | | 184 | 145 | 39 |
| 1989-05-20 | vs BOS | 42 | W 6-3 | 28-14 | 1 | 43,427 | Dave Stewart | Wes Gardner | Dave Stewart | Wes Gardner | Dennis Eckersley | 190 | 148 | 42 |
| 1989-05-21 | vs BOS | 43 | W 5-4 | 29-14 | 1 | 44,505 | Curt Young | Roger Clemens | Todd Burns | Roger Clemens | Dennis Eckersley | 195 | 152 | 43 |
| 1989-05-23 | @ MIL | 44 | L 1-9 | 29-15 | 1 | 13,882 | Bob Welch | Chris Bosio | Chris Bosio | Bob Welch | | 196 | 161 | 35 |
| 1989-05-24 | @ MIL | 45 | W 6-2 | 30-15 | 1 | 13,932 | Mike Moore | Mike Birkbeck | Mike Moore | Mike Birkbeck | | 202 | 163 | 39 |
| 1989-05-25 | @ MIL | 46 | L 1-4 | 30-16 | 1 | 18,898 | Dave Stewart | Bryan Clutterbuck | Bryan Clutterbuck | Dave Stewart | Dan Plesac | 203 | 167 | 36 |
| 1989-05-26 | @ NYA | 47 | W 4-0 | 31-16 | 1 | 28,726 | Todd Burns | Andy Hawkins | Todd Burns | Andy Hawkins | | 207 | 167 | 40 |
| 1989-05-27 | @ NYA | 48 | W 3-0 | 32-16 | 1 | 28,111 | Curt Young | Dave LaPoint | Curt Young | Dave LaPoint | Rick Honeycutt | 210 | 167 | 43 |
| 1989-05-28 | @ NYA | 49 | W 4-3 | 33-16 | 1 | 38,527 | Mike Moore | Clay Parker | Mike Moore | Clay Parker | Rick Honeycutt | 214 | 170 | 44 |
| 1989-05-29 | @ BOS | 50 | L 2-3 | 33-17 | 2 | 33,344 | Bob Welch | Mike Boddicker | Lee Smith | Bob Welch | | 216 | 173 | 43 |
| 1989-05-30 | @ BOS | 51 | W 4-2 | 34-17 | 2 | 31,407 | Dave Stewart | Mike Smithson | Dave Stewart | Mike Smithson | Rick Honeycutt | 220 | 175 | 45 |
| 1989-05-31 | @ BOS | 52 | L 3-4 | 34-18 | 2 | 33,510 | Todd Burns | Roger Clemens | Lee Smith | Eric Plunk | | 223 | 179 | 44 |
| 1989-06-02 | vs CLE | 53 | L 3-5 | 34-19 | 2 | 28,052 | Mike Moore | Greg Swindell | Greg Swindell | Mike Moore | Doug Jones | 226 | 184 | 42 |
| 1989-06-03 | vs CLE | 54 | W 7-0 | 35-19 | 2 | 35,466 | Bob Welch | Tom Candiotti | Bob Welch | Tom Candiotti | | 233 | 184 | 49 |
| 1989-06-04 | vs CLE | 55 | W 4-0 | 36-19 | 2 | 34,610 | Dave Stewart | John Farrell | Dave Stewart | John Farrell | | 237 | 184 | 53 |
| 1989-06-05 | vs MIN | 56 | L 1-2 | 36-20 | 2 | 34,320 | Curt Young | Francisco Oliveras | Francisco Oliveras | Curt Young | Jeff Reardon | 238 | 186 | 52 |
| 1989-06-06 | vs MIN | 57 | W 1-0 | 37-20 | 2 | 23,505 | Mike Moore | Allan Anderson | Mike Moore | Allan Anderson | | 239 | 186 | 53 |
| 1989-06-07 | vs MIN | 58 | W 3-2 | 38-20 | 1 | 27,396 | Bob Welch | Frank Viola | Bob Welch | Frank Viola | Todd Burns | 242 | 188 | 54 |
| 1989-06-09 | @ TEX | 59 | L 8-11 | 38-21 | 1 | 35,799 | Dave Stewart | Charlie Hough | Cecilio Guante | Gene Nelson | Jeff Russell | 250 | 199 | 51 |
| 1989-06-10 | @ TEX | 60 | W 5-1 | 39-21 | 1 | 40,796 | Storm Davis | Bobby Witt | Storm Davis | Bobby Witt | | 255 | 200 | 55 |
| 1989-06-11 | @ TEX | 61 | W 5-1 | 40-21 | 1 | 32,127 | Mike Moore | Kevin Brown | Mike Moore | Kevin Brown | Gene Nelson | 260 | 201 | 59 |
| 1989-06-12 | @ KCA | 62 | L 1-2 | 40-22 | 1 | 39,387 | Bob Welch | Mark Gubicza | Tom Gordon | Todd Burns | | 261 | 203 | 58 |
| 1989-06-13 | @ KCA | 63 | L 3-5 | 40-23 | 1 | 29,816 | Curt Young | Kevin Appier | Kevin Appier | Curt Young | Steve Farr | 264 | 208 | 56 |
| 1989-06-14 | @ KCA | 64 | W 2-1 | 41-23 | 1 | 31,087 | Dave Stewart | Charlie Leibrandt | Dave Stewart | Charlie Leibrandt | Rick Honeycutt | 266 | 209 | 57 |
| 1989-06-16 | @ BAL | 65 | W 7-5 | 42-24 | 1 | 0 | Storm Davis | Brian Holton | Storm Davis | Brian Holton | Rick Honeycutt | 273 | 214 | 59 |
| 1989-06-16 | @ BAL | 66 | L 1-5 | 42-24 | 1 | 40,707 | Mike Moore | Jay Tibbs | Jay Tibbs | Mike Moore | | 274 | 219 | 55 |
| 1989-06-17 | @ BAL | 67 | L 2-4 | 42-25 | 1 | 36,431 | Matt Young | Jose Bautista | Jose Bautista | Matt Young | Gregg Olson | 276 | 223 | 53 |
| 1989-06-18 | @ BAL | 68 | L 2-4 | 42-26 | 1 | 46,541 | Curt Young | Dave J. Schmidt | Dave J. Schmidt | Curt Young | Mickey Weston | 278 | 227 | 51 |
| 1989-06-19 | vs DET | 69 | L 4-6 | 42-27 | 1 | 38,607 | Dave Stewart | Frank Tanana | Frank Tanana | Dave Stewart | Mike Henneman | 282 | 233 | 49 |
| 1989-06-20 | vs DET | 70 | W 6-4 | 43-27 | 1 | 30,184 | Storm Davis | Charles Hudson | Gene Nelson | Brad Havens | Todd Burns | 288 | 237 | 51 |
| 1989-06-21 | vs DET | 71 | W 6-3 | 44-27 | 1 | 28,654 | Mike Moore | Mike Schwabe | Mike Moore | Mike Schwabe | Rick Honeycutt | 294 | 240 | 54 |
| 1989-06-22 | vs TOR | 72 | L 2-4 | 44-28 | 1 | 21,418 | Matt Young | John Cerutti | Xavier Hernandez | Jim Corsi | David Wells | 296 | 244 | 52 |
| 1989-06-23 | vs TOR | 73 | L 8-10 | 44-29 | 1 | 27,795 | Curt Young | Frank Wills | DeWayne Buice | Curt Young | Tom Henke | 304 | 254 | 50 |
| 1989-06-24 | vs TOR | 74 | W 7-1 | 45-29 | 1 | 39,659 | Dave Stewart | Dave Stieb | Dave Stewart | Dave Stieb | | 311 | 255 | 56 |
| 1989-06-25 | vs TOR | 75 | W 6-3 | 46-29 | 1 | 49,219 | Storm Davis | Jimmy Key | Storm Davis | Jimmy Key | Rick Honeycutt | 317 | 258 | 59 |
| 1989-06-26 | @ MIN | 76 | L 3-4 | 46-30 | 1 | 31,914 | Mike Moore | Shane Rawley | Jeff Reardon | Todd Burns | | 320 | 262 | 58 |
| 1989-06-27 | @ MIN | 77 | L 5-11 | 46-31 | 1 | 37,891 | Matt Young | Roy Smith | Gary Wayne | Gene Nelson | Juan Berenguer | 325 | 273 | 52 |
| 1989-06-28 | @ MIN | 78 | L 0-2 | 46-32 | 1 | 41,387 | Dave Stewart | Frank Viola | Frank Viola | Dave Stewart | | 325 | 275 | 50 |
| 1989-06-30 | @ CLE | 79 | W 5-0 | 47-32 | 1 | 27,435 | Bob Welch | Greg Swindell | Bob Welch | Greg Swindell | Rick Honeycutt | 330 | 275 | 55 |
| 1989-07-01 | @ CLE | 80 | W 6-4 | 48-32 | 1 | 18,826 | Mike Moore | Tom Candiotti | Mike Moore | Rich Yett | Todd Burns | 336 | 279 | 57 |
| 1989-07-02 | @ CLE | 81 | W 11-3 | 49-32 | 1 | 22,549 | Storm Davis | John Farrell | Storm Davis | John Farrell | | 347 | 282 | 65 |
| 1989-07-03 | vs KCA | 82 | W 1-0 | 50-32 | 1 | 36,763 | Dave Stewart | Mark Gubicza | Dave Stewart | Mark Gubicza | Rick Honeycutt | 348 | 282 | 66 |
| 1989-07-04 | vs KCA | 83 | L 1-10 | 50-33 | 1 | 46,031 | Matt Young | Bret Saberhagen | Bret Saberhagen | Matt Young | | 349 | 292 | 57 |
| 1989-07-05 | vs KCA | 84 | L 9-12 | 50-34 | 2 | 20,791 | Bob Welch | Charlie Leibrandt | Steve Crawford | Rick Honeycutt | | 358 | 304 | 54 |
| 1989-07-06 | vs KCA | 85 | W 3-1 | 51-34 | 1 | 21,985 | Mike Moore | Luis Aquino | Mike Moore | Luis Aquino | Todd Burns | 361 | 305 | 56 |
| 1989-07-07 | vs TEX | 86 | L 3-6 | 51-35 | 2 | 39,678 | Storm Davis | Bobby Witt | Bobby Witt | Storm Davis | Jeff Russell | 364 | 311 | 53 |
| 1989-07-08 | vs TEX | 87 | L 4-5 | 51-36 | 2 | 38,220 | Dave Stewart | Kevin Brown | Jeff Russell | Matt Young | | 368 | 316 | 52 |
| 1989-07-09 | vs TEX | 88 | W 7-1 | 52-36 | 2 | 40,060 | Bob Welch | Charlie Hough | Bob Welch | Charlie Hough | Rick Honeycutt | 375 | 317 | 58 |
| 1989-07-13 | @ TOR | 89 | W 11-7 | 53-36 | 2 | 48,207 | Storm Davis | Jimmy Key | Todd Burns | Jimmy Key | | 386 | 324 | 62 |
| 1989-07-14 | @ TOR | 90 | L 1-4 | 53-37 | 2 | 48,325 | Bob Welch | Dave Stieb | Dave Stieb | Bob Welch | Duane Ward | 387 | 328 | 59 |
| 1989-07-15 | @ TOR | 91 | L 1-6 | 53-38 | 2 | 48,238 | Dave Stewart | Mike Flanagan | Mike Flanagan | Dave Stewart | | 388 | 334 | 54 |
| 1989-07-16 | @ TOR | 92 | W 6-2 | 54-38 | 2 | 48,405 | Mike Moore | John Cerutti | Mike Moore | John Cerutti | Todd Burns | 394 | 336 | 58 |
| 1989-07-17 | @ DET | 93 | L 1-2 | 54-39 | 2 | 21,844 | Curt Young | Paul Gibson | Mike Henneman | Gene Nelson | | 395 | 338 | 57 |
| 1989-07-18 | @ DET | 94 | W 7-2 | 55-39 | 2 | 21,792 | Storm Davis | Dave Beard | Storm Davis | Dave Beard | | 402 | 340 | 62 |
| 1989-07-20 | vs BAL | 95 | W 5-2 | 56-39 | 2 | 30,697 | Dave Stewart | Dave J. Schmidt | Dave Stewart | Dave J. Schmidt | Dennis Eckersley | 407 | 342 | 65 |
| 1989-07-21 | vs BAL | 96 | W 3-2 | 57-39 | 2 | 30,848 | Mike Moore | Bob Milacki | Mike Moore | Gregg Olson | | 410 | 344 | 66 |
| 1989-07-22 | vs BAL | 97 | W 3-1 | 58-39 | 2 | 37,241 | Bob Welch | Pete Harnisch | Bob Welch | Pete Harnisch | Dennis Eckersley | 413 | 345 | 68 |
| 1989-07-23 | vs BAL | 98 | W 3-2 | 59-39 | 2 | 43,570 | Storm Davis | Jeff Ballard | Storm Davis | Jeff Ballard | Dennis Eckersley | 416 | 347 | 69 |
| 1989-07-24 | vs CAL | 99 | L 4-5 | 59-40 | 2 | 44,548 | Curt Young | Kirk McCaskill | Willie Fraser | Gene Nelson | Bryan Harvey | 420 | 352 | 68 |
| 1989-07-25 | vs CAL | 100 | L 0-4 | 59-41 | 2 | 43,529 | Dave Stewart | Chuck Finley | Chuck Finley | Dave Stewart | Greg Minton | 420 | 356 | 64 |
| 1989-07-26 | vs CAL | 101 | W 9-5 | 60-41 | 2 | 44,588 | Mike Moore | Mike Witt | Matt Young | Mike Witt | | 429 | 361 | 68 |
| 1989-07-28 | vs SEA | 102 | W 8-7 | 61-41 | 2 | 36,446 | Bob Welch | Mike Dunne | Todd Burns | Gene Harris | | 437 | 368 | 69 |
| 1989-07-29 | vs SEA | 103 | L 6-14 | 61-42 | 2 | 40,734 | Storm Davis | Randy Johnson | Randy Johnson | Storm Davis | Bill Swift | 443 | 382 | 61 |
| 1989-07-30 | vs SEA | 104 | W 5-3 | 62-42 | 2 | 43,898 | Dave Stewart | Brian Holman | Dave Stewart | Brian Holman | Dennis Eckersley | 448 | 385 | 63 |
| 1989-07-31 | vs CHA | 105 | W 3-2 | 63-42 | 2 | 34,554 | Mike Moore | Eric King | Mike Moore | Bobby Thigpen | | 451 | 387 | 64 |
| 1989-08-01 | vs CHA | 106 | W 2-0 | 64-42 | 1 | 22,536 | Curt Young | Greg Hibbard | Curt Young | Greg Hibbard | Dennis Eckersley | 453 | 387 | 66 |
| 1989-08-02 | vs CHA | 107 | W 2-0 | 65-42 | 1 | 25,146 | Storm Davis | Melido Perez | Storm Davis | Melido Perez | Rick Honeycutt | 455 | 387 | 68 |
| 1989-08-03 | vs CHA | 108 | L 4-6 | 65-43 | 2 | 31,974 | Bob Welch | Richard Dotson | Donn Pall | Bob Welch | Bobby Thigpen | 459 | 393 | 66 |
| 1989-08-04 | @ SEA | 109 | W 5-3 | 66-43 | 2 | 23,621 | Dave Stewart | Brian Holman | Dave Stewart | Brian Holman | Dennis Eckersley | 464 | 396 | 68 |
| 1989-08-05 | @ SEA | 110 | L 5-11 | 66-44 | 2 | 36,961 | Mike Moore | Scott Bankhead | Scott Bankhead | Mike Moore | Michael Jackson | 469 | 407 | 62 |
| 1989-08-06 | @ SEA | 111 | W 2-1 | 67-44 | 2 | 19,303 | Storm Davis | Mike Dunne | Storm Davis | Mike Dunne | Dennis Eckersley | 471 | 408 | 63 |
| 1989-08-07 | @ SEA | 112 | L 1-5 | 67-45 | 2 | 31,334 | Bob Welch | Clint Zavaras | Clint Zavaras | Bob Welch | | 472 | 413 | 59 |
| 1989-08-08 | @ CHA | 113 | W 3-2 | 68-45 | 2 | 17,832 | Dave Stewart | Melido Perez | Rick Honeycutt | Donn Pall | Dennis Eckersley | 475 | 415 | 60 |
| 1989-08-09 | @ CHA | 114 | L 2-3 | 68-46 | 2 | 15,389 | Curt Young | Richard Dotson | Tom McCarthy | Jim Corsi | | 477 | 418 | 59 |
| 1989-08-10 | @ CHA | 115 | W 4-1 | 69-46 | 2 | 16,173 | Storm Davis | Steve Rosenberg | Storm Davis | Steve Rosenberg | Dennis Eckersley | 481 | 419 | 62 |
| 1989-08-11 | @ CAL | 116 | W 5-0 | 70-46 | 1 | 61,696 | Mike Moore | Mike Witt | Mike Moore | Mike Witt | | 486 | 419 | 67 |
| 1989-08-12 | @ CAL | 117 | W 8-3 | 71-46 | 1 | 53,036 | Bob Welch | Jim Abbott | Bob Welch | Jim Abbott | Todd Burns | 494 | 422 | 72 |
| 1989-08-13 | @ CAL | 118 | L 3-4 | 71-47 | 1 | 60,326 | Dave Stewart | Bert Blyleven | Bert Blyleven | Dave Stewart | Bryan Harvey | 497 | 426 | 71 |
| 1989-08-15 | vs CLE | 119 | W 5-2 | 72-47 | 1 | 28,459 | Storm Davis | Rod Nichols | Storm Davis | Rod Nichols | Dennis Eckersley | 502 | 428 | 74 |
| 1989-08-16 | vs CLE | 120 | L 3-6 | 72-48 | 1 | 29,502 | Mike Moore | Buddy Black | Steve Olin | Rick Honeycutt | Doug Jones | 505 | 434 | 71 |
| 1989-08-17 | vs CLE | 121 | W 1-0 | 73-48 | 1 | 35,071 | Bob Welch | John Farrell | Bob Welch | John Farrell | Dennis Eckersley | 506 | 434 | 72 |
| 1989-08-18 | vs MIN | 122 | L 3-4 | 73-49 | 2 | 38,956 | Dave Stewart | Roy Smith | Roy Smith | Dave Stewart | Jeff Reardon | 509 | 438 | 71 |
| 1989-08-19 | vs MIN | 123 | W 5-4 | 74-49 | 2 | 44,123 | Storm Davis | Rick Aguilera | Storm Davis | Gary Wayne | | 514 | 442 | 72 |
| 1989-08-20 | vs MIN | 124 | W 5-0 | 75-49 | 2 | 43,875 | Mike Moore | Allan Anderson | Mike Moore | Allan Anderson | | 519 | 442 | 77 |
| 1989-08-21 | @ DET | 125 | W 6-1 | 76-49 | 1 | 6,197 | Curt Young | Frank Tanana | Curt Young | Frank Tanana | | 525 | 443 | 82 |
| 1989-08-22 | @ TEX | 126 | W 2-0 | 77-49 | 1 | 42,869 | Bob Welch | Nolan Ryan | Bob Welch | Nolan Ryan | Dennis Eckersley | 527 | 443 | 84 |
| 1989-08-23 | @ TEX | 127 | W 5-4 | 78-49 | 1 | 23,453 | Dave Stewart | Kevin Brown | Dave Stewart | Kevin Brown | Dennis Eckersley | 532 | 447 | 85 |
| 1989-08-24 | @ TEX | 128 | L 2-6 | 78-50 | 1 | 25,604 | Storm Davis | Mike Jeffcoat | Mike Jeffcoat | Storm Davis | Gary Mielke | 534 | 453 | 81 |
| 1989-08-25 | @ KCA | 129 | L 1-3 | 78-51 | 1 | 38,263 | Mike Moore | Mark Gubicza | Mark Gubicza | Mike Moore | Jeff Montgomery | 535 | 456 | 79 |
| 1989-08-26 | @ KCA | 130 | L 0-2 | 78-52 | 1 | 41,253 | Curt Young | Bret Saberhagen | Bret Saberhagen | Curt Young | | 535 | 458 | 77 |
| 1989-08-27 | @ KCA | 131 | W 6-0 | 79-52 | 1 | 38,263 | Bob Welch | Tom Gordon | Bob Welch | Tom Gordon | | 541 | 458 | 83 |
| 1989-08-28 | @ NYA | 132 | W 7-3 | 80-52 | 1 | 25,359 | Dave Stewart | Andy Hawkins | Dave Stewart | Andy Hawkins | Dennis Eckersley | 548 | 461 | 87 |
| 1989-08-29 | @ NYA | 133 | W 19-5 | 81-52 | 1 | 27,751 | Storm Davis | Chuck Cary | Storm Davis | Chuck Cary | | 567 | 466 | 101 |
| 1989-08-30 | @ NYA | 134 | L 5-8 | 81-53 | 1 | 26,238 | Mike Moore | Eric Plunk | Eric Plunk | Mike Moore | Lance McCullers | 572 | 474 | 98 |
| 1989-09-01 | @ MIL | 135 | L 5-6 | 81-54 | 1 | 17,465 | Bob Welch | Chris Bosio | Chuck Crim | Todd Burns | | 577 | 480 | 97 |
| 1989-09-02 | @ MIL | 136 | W 7-2 | 82-54 | 1 | 36,980 | Dave Stewart | Tom Filer | Dave Stewart | Tom Filer | | 584 | 482 | 102 |
| 1989-09-03 | @ MIL | 137 | W 5-0 | 83-54 | 1 | 30,583 | Storm Davis | Jaime Navarro | Storm Davis | Jaime Navarro | Gene Nelson | 589 | 482 | 107 |
| 1989-09-04 | vs BOS | 138 | L 5-8 | 83-55 | 1 | 32,697 | Mike Moore | John Dopson | John Dopson | Mike Moore | Lee Smith | 594 | 490 | 104 |
| 1989-09-05 | vs BOS | 139 | W 13-1 | 84-55 | 1 | 28,541 | Curt Young | Roger Clemens | Curt Young | Roger Clemens | | 607 | 491 | 116 |
| 1989-09-06 | vs BOS | 140 | W 7-5 | 85-55 | 1 | 25,037 | Bob Welch | Mike Smithson | Bob Welch | Mike Smithson | Dennis Eckersley | 614 | 496 | 118 |
| 1989-09-08 | vs NYA | 141 | L 1-5 | 85-56 | 1 | 43,626 | Dave Stewart | Andy Hawkins | Dale Mohorcic | Dave Stewart | | 615 | 501 | 114 |
| 1989-09-09 | vs NYA | 142 | W 7-0 | 86-56 | 1 | 43,760 | Mike Moore | Clay Parker | Mike Moore | Clay Parker | | 622 | 501 | 121 |
| 1989-09-10 | vs NYA | 143 | W 6-2 | 87-56 | 1 | 44,071 | Storm Davis | Eric Plunk | Storm Davis | Eric Plunk | | 628 | 503 | 125 |
| 1989-09-12 | vs MIL | 144 | L 6-7 | 87-57 | 1 | 23,862 | Bob Welch | Chris Bosio | Don August | Matt Young | Dan Plesac | 634 | 510 | 124 |
| 1989-09-13 | vs MIL | 145 | W 7-6 | 88-57 | 1 | 21,246 | Dave Stewart | Tom Filer | Dennis Eckersley | Chuck Crim | | 641 | 516 | 125 |
| 1989-09-15 | @ BOS | 146 | L 2-7 | 88-58 | 1 | 33,533 | Mike Moore | Roger Clemens | Roger Clemens | Mike Moore | | 643 | 523 | 120 |
| 1989-09-16 | @ BOS | 147 | L 2-5 | 88-59 | 1 | 33,778 | Storm Davis | John Dopson | John Dopson | Storm Davis | Dennis Lamp | 645 | 528 | 117 |
| 1989-09-17 | @ BOS | 148 | L 6-7 | 88-60 | 1 | 33,148 | Bob Welch | Eric Hetzel | Greg Harris | Bob Welch | Lee Smith | 651 | 535 | 116 |
| 1989-09-18 | @ CLE | 149 | W 4-2 | 89-60 | 1 | 5,931 | Dave Stewart | Tom Candiotti | Dennis Eckersley | Steve Olin | | 655 | 537 | 118 |
| 1989-09-19 | @ CLE | 150 | W 5-1 | 90-60 | 1 | 6,085 | Mike Moore | Rod Nichols | Mike Moore | Rod Nichols | | 660 | 538 | 122 |
| 1989-09-20 | @ CLE | 151 | W 8-6 | 91-60 | 1 | 6,186 | Storm Davis | Greg Swindell | Storm Davis | Greg Swindell | Dennis Eckersley | 668 | 544 | 124 |
| 1989-09-21 | @ MIN | 152 | W 2-1 | 92-60 | 1 | 16,779 | Bob Welch | Rick Aguilera | Bob Welch | Rick Aguilera | Dennis Eckersley | 670 | 545 | 125 |
| 1989-09-22 | @ MIN | 153 | W 5-2 | 93-60 | 1 | 34,830 | Dave Stewart | Mike Dyer | Dave Stewart | Mike Dyer | Gene Nelson | 675 | 547 | 128 |
| 1989-09-23 | @ MIN | 154 | L 3-5 | 93-61 | 1 | 38,791 | Mike Moore | Allan Anderson | Allan Anderson | Mike Moore | Roy Smith | 678 | 552 | 126 |
| 1989-09-24 | @ MIN | 155 | W 9-3 | 94-61 | 1 | 22,565 | Storm Davis | Kevin Tapani | Storm Davis | Kevin Tapani | Dennis Eckersley | 687 | 555 | 132 |
| 1989-09-25 | vs TEX | 156 | L 2-3 | 94-62 | 1 | 32,701 | Bob Welch | Charlie Hough | Drew Hall | Todd Burns | Jeff Russell | 689 | 558 | 131 |
| 1989-09-26 | vs TEX | 157 | W 4-3 | 95-62 | 1 | 23,119 | Curt Young | Mike Jeffcoat | Dennis Eckersley | Mike Jeffcoat | | 693 | 561 | 132 |
| 1989-09-27 | vs TEX | 158 | W 5-0 | 96-62 | 1 | 32,280 | Mike Moore | Jamie Moyer | Mike Moore | Jamie Moyer | | 698 | 561 | 137 |
| 1989-09-28 | vs TEX | 159 | W 5-3 | 97-62 | 1 | 21,127 | Dave Stewart | Brad Arnsberg | Dave Stewart | Brad Arnsberg | Dennis Eckersley | 703 | 564 | 139 |
| 1989-09-29 | vs KCA | 160 | W 4-3 | 98-62 | 1 | 43,470 | Storm Davis | Steve Farr | Gene Nelson | Rick Luecken | | 707 | 567 | 140 |
| 1989-09-30 | vs KCA | 161 | L 1-6 | 98-63 | 1 | 42,891 | Bob Welch | Bret Saberhagen | Bret Saberhagen | Todd Burns | | 708 | 573 | 135 |
| 1989-10-01 | vs KCA | 162 | W 4-3 | 99-63 | 1 | 43,755 | Dave Otto | Jose De Jesus | Jim Corsi | Terry Leach | | 712 | 576 | 136 |