| 1989-04-04 | @ MIN | 1 | W 4-2 | 1-0 | 3 | 52,394 | Tommy John | Frank Viola | Tommy John | Frank Viola | Dale Mohorcic | 4 | 2 | 2 |
| 1989-04-05 | @ MIN | 2 | L 2-12 | 1-1 | 3 | 22,556 | Andy Hawkins | Allan Anderson | Allan Anderson | Andy Hawkins | | 6 | 14 | -8 |
| 1989-04-06 | @ MIN | 3 | L 1-7 | 1-2 | 4 | 22,133 | Dave LaPoint | Shane Rawley | Shane Rawley | Dave LaPoint | | 7 | 21 | -14 |
| 1989-04-07 | vs CLE | 4 | L 2-4 | 1-3 | 6 | 55,655 | John Candelaria | Rich Yett | Rich Yett | John Candelaria | Doug Jones | 9 | 25 | -16 |
| 1989-04-08 | vs CLE | 5 | L 1-11 | 1-4 | 6 | 20,369 | Al Leiter | Greg Swindell | Greg Swindell | Al Leiter | | 10 | 36 | -26 |
| 1989-04-09 | vs CLE | 6 | L 3-4 | 1-5 | 7 | 25,328 | Tommy John | Tom Candiotti | Tom Candiotti | Tommy John | Doug Jones | 13 | 40 | -27 |
| 1989-04-10 | vs TOR | 7 | L 0-8 | 1-6 | 7 | 17,192 | Andy Hawkins | Dave Stieb | Dave Stieb | Andy Hawkins | | 13 | 48 | -35 |
| 1989-04-11 | vs TOR | 8 | L 6-11 | 1-7 | 7 | 20,277 | Dave LaPoint | Mike Flanagan | Tom Henke | Dave Righetti | | 19 | 59 | -40 |
| 1989-04-12 | vs TOR | 9 | W 5-3 | 2-7 | 6 | 17,900 | John Candelaria | Jeff Musselman | John Candelaria | Tony Castillo | Lee Guetterman | 24 | 62 | -38 |
| 1989-04-14 | vs MIN | 10 | W 8-5 | 3-7 | 6 | 46,028 | Al Leiter | Frank Viola | Al Leiter | Mike Cook | Lee Guetterman | 32 | 67 | -35 |
| 1989-04-16 | vs MIN | 11 | L 4-9 | 3-8 | 6 | 30,195 | Tommy John | Allan Anderson | Allan Anderson | Tommy John | | 36 | 76 | -40 |
| 1989-04-17 | @ TOR | 12 | W 7-2 | 4-8 | 6 | 23,260 | Andy Hawkins | Mike Flanagan | Andy Hawkins | Mike Flanagan | | 43 | 78 | -35 |
| 1989-04-18 | @ TOR | 13 | W 2-0 | 5-8 | 6 | 25,040 | Dave LaPoint | Jeff Musselman | Dave LaPoint | Jeff Musselman | Dave Righetti | 45 | 78 | -33 |
| 1989-04-19 | @ TOR | 14 | W 4-2 | 6-8 | 4 | 26,471 | John Candelaria | Jimmy Key | John Candelaria | Jimmy Key | Lee Guetterman | 49 | 80 | -31 |
| 1989-04-21 | @ CLE | 15 | L 5-6 | 6-9 | 6 | 14,793 | Al Leiter | Greg Swindell | Doug Jones | Dale Mohorcic | | 54 | 86 | -32 |
| 1989-04-22 | @ CLE | 16 | L 1-3 | 6-10 | 6 | 16,607 | Tommy John | Tom Candiotti | Scott Bailes | Tommy John | | 55 | 89 | -34 |
| 1989-04-23 | @ CLE | 17 | W 5-0 | 7-10 | 6 | 22,128 | Andy Hawkins | John Farrell | Andy Hawkins | John Farrell | | 60 | 89 | -29 |
| 1989-04-24 | @ CLE | 18 | W 6-3 | 8-10 | 3 | 13,720 | Dave LaPoint | Buddy Black | Dave LaPoint | Buddy Black | Dave Righetti | 66 | 92 | -26 |
| 1989-04-25 | @ KCA | 19 | L 3-5 | 8-11 | 4 | 26,479 | John Candelaria | Bret Saberhagen | Bret Saberhagen | John Candelaria | | 69 | 97 | -28 |
| 1989-04-26 | @ KCA | 20 | L 3-5 | 8-12 | 4 | 26,544 | Al Leiter | Floyd Bannister | Tom Gordon | Al Leiter | Steve Farr | 72 | 102 | -30 |
| 1989-04-27 | @ KCA | 21 | W 3-2 | 9-12 | 4 | 35,173 | Tommy John | Mark Gubicza | Tommy John | Mark Gubicza | Dave Righetti | 75 | 104 | -29 |
| 1989-04-28 | vs CHA | 22 | W 3-1 | 10-12 | 3 | 26,984 | Andy Hawkins | Shawn Hillegas | Andy Hawkins | Shawn Hillegas | Dave Righetti | 78 | 105 | -27 |
| 1989-04-29 | vs CHA | 23 | W 8-2 | 11-12 | 2 | 18,578 | Dave LaPoint | Bill Long | Dave LaPoint | Bill Long | Dale Mohorcic | 86 | 107 | -21 |
| 1989-04-30 | vs CHA | 24 | W 5-2 | 12-12 | 2 | 35,813 | John Candelaria | Melido Perez | John Candelaria | Melido Perez | Lance McCullers | 91 | 109 | -18 |
| 1989-05-02 | vs KCA | 25 | L 3-5 | 12-13 | 3 | 20,587 | Tommy John | Mark Gubicza | Mark Gubicza | Tommy John | | 94 | 114 | -20 |
| 1989-05-03 | @ TEX | 26 | L 1-4 | 12-14 | 4 | 18,898 | Andy Hawkins | Kevin Brown | Kevin Brown | Andy Hawkins | | 95 | 118 | -23 |
| 1989-05-04 | @ TEX | 27 | W 11-7 | 13-14 | 4 | 26,856 | Dave LaPoint | Charlie Hough | Dave LaPoint | Charlie Hough | | 106 | 125 | -19 |
| 1989-05-05 | @ CHA | 28 | W 7-5 | 14-14 | 3 | 14,996 | John Candelaria | Melido Perez | Lance McCullers | Donn Pall | Lee Guetterman | 113 | 130 | -17 |
| 1989-05-06 | @ CHA | 29 | W 5-2 | 15-14 | 2 | 16,617 | Richard Dotson | Jerry Reuss | Dave Righetti | Steve Rosenberg | | 118 | 132 | -14 |
| 1989-05-07 | @ CHA | 30 | L 2-6 | 15-15 | 3 | 20,603 | Tommy John | Eric King | Eric King | Tommy John | Bobby Thigpen | 120 | 138 | -18 |
| 1989-05-08 | vs TEX | 31 | L 2-13 | 15-16 | 3 | 18,163 | Andy Hawkins | Kevin Brown | Kevin Brown | Andy Hawkins | | 122 | 151 | -29 |
| 1989-05-09 | vs TEX | 32 | W 5-3 | 16-16 | 3 | 21,978 | Dave LaPoint | Charlie Hough | Dave LaPoint | Charlie Hough | Dave Righetti | 127 | 154 | -27 |
| 1989-05-12 | @ CAL | 33 | W 5-2 | 17-16 | 2 | 41,846 | Richard Dotson | Jim Abbott | Richard Dotson | Jim Abbott | Lee Guetterman | 132 | 156 | -24 |
| 1989-05-13 | @ CAL | 34 | L 1-6 | 17-17 | 2 | 33,528 | Tommy John | Mike Witt | Mike Witt | Tommy John | | 133 | 162 | -29 |
| 1989-05-14 | @ CAL | 35 | L 0-5 | 17-18 | 3 | 36,690 | Andy Hawkins | Chuck Finley | Chuck Finley | Andy Hawkins | Greg Minton | 133 | 167 | -34 |
| 1989-05-15 | @ CAL | 36 | L 3-4 | 17-19 | 3 | 25,959 | Dave LaPoint | Bert Blyleven | Willie Fraser | Lance McCullers | | 136 | 171 | -35 |
| 1989-05-16 | @ OAK | 37 | W 3-2 | 18-19 | 1 | 25,852 | Clay Parker | Curt Young | Clay Parker | Curt Young | Dave Righetti | 139 | 173 | -34 |
| 1989-05-17 | @ OAK | 38 | L 3-8 | 18-20 | 2 | 24,505 | Richard Dotson | Storm Davis | Storm Davis | Richard Dotson | Dennis Eckersley | 142 | 181 | -39 |
| 1989-05-18 | @ OAK | 39 | L 2-6 | 18-21 | 4 | 40,758 | Tommy John | Bob Welch | Bob Welch | Tommy John | Todd Burns | 144 | 187 | -43 |
| 1989-05-19 | @ SEA | 40 | W 9-5 | 19-21 | 3 | 39,340 | Andy Hawkins | Erik Hanson | Andy Hawkins | Erik Hanson | Lee Guetterman | 153 | 192 | -39 |
| 1989-05-20 | @ SEA | 41 | L 4-6 | 19-22 | 4 | 40,563 | Dave LaPoint | Mike Dunne | Steve Trout | Dave LaPoint | Mike Schooler | 157 | 198 | -41 |
| 1989-05-21 | @ SEA | 42 | W 6-2 | 20-22 | 2 | 35,524 | Clay Parker | Mark Langston | Clay Parker | Mark Langston | | 163 | 200 | -37 |
| 1989-05-24 | vs CAL | 43 | L 4-11 | 20-23 | 4 | 19,144 | Richard Dotson | Jim Abbott | Jim Abbott | Richard Dotson | Greg Minton | 167 | 211 | -44 |
| 1989-05-25 | vs CAL | 44 | W 8-6 | 21-23 | 3 | 23,354 | Tommy John | Mike Witt | Dale Mohorcic | Willie Fraser | Dave Righetti | 175 | 217 | -42 |
| 1989-05-26 | vs OAK | 45 | L 0-4 | 21-24 | 3 | 28,726 | Andy Hawkins | Todd Burns | Todd Burns | Andy Hawkins | | 175 | 221 | -46 |
| 1989-05-27 | vs OAK | 46 | L 0-3 | 21-25 | 3 | 28,111 | Dave LaPoint | Curt Young | Curt Young | Dave LaPoint | Rick Honeycutt | 175 | 224 | -49 |
| 1989-05-28 | vs OAK | 47 | L 3-4 | 21-26 | 5 | 38,527 | Clay Parker | Mike Moore | Mike Moore | Clay Parker | Rick Honeycutt | 178 | 228 | -50 |
| 1989-05-29 | vs SEA | 48 | W 6-3 | 22-26 | 4 | 31,897 | Richard Dotson | Dennis Powell | Richard Dotson | Dennis Powell | Dave Righetti | 184 | 231 | -47 |
| 1989-05-30 | vs SEA | 49 | L 2-3 | 22-27 | 4 | 15,275 | Jimmy Jones | Randy Johnson | Randy Johnson | Jimmy Jones | Mike Schooler | 186 | 234 | -48 |
| 1989-05-31 | vs SEA | 50 | W 9-5 | 23-27 | 4 | 22,946 | Andy Hawkins | Brian Holman | Andy Hawkins | Steve Trout | Lee Guetterman | 195 | 239 | -44 |
| 1989-06-01 | @ MIL | 51 | L 0-5 | 23-28 | 5 | 18,991 | Dave LaPoint | Teddy Higuera | Teddy Higuera | Dave LaPoint | Jay Aldrich | 195 | 244 | -49 |
| 1989-06-02 | @ MIL | 52 | W 3-2 | 24-28 | 4 | 28,876 | Clay Parker | Chris Bosio | Dave Righetti | Chuck Crim | | 198 | 246 | -48 |
| 1989-06-03 | @ MIL | 53 | L 0-2 | 24-29 | 5 | 47,387 | Richard Dotson | Bill Krueger | Bill Krueger | Richard Dotson | Dan Plesac | 198 | 248 | -50 |
| 1989-06-04 | @ MIL | 54 | W 12-9 | 25-29 | 4 | 52,179 | Jimmy Jones | Bryan Clutterbuck | Jimmy Jones | Bryan Clutterbuck | Lee Guetterman | 210 | 257 | -47 |
| 1989-06-05 | vs BAL | 55 | L 3-16 | 25-30 | 5 | 24,711 | Andy Hawkins | Jeff Ballard | Jeff Ballard | Andy Hawkins | | 213 | 273 | -60 |
| 1989-06-06 | vs BAL | 56 | W 4-0 | 26-30 | 5 | 24,260 | Dave LaPoint | Dave J. Schmidt | Dave LaPoint | Dave J. Schmidt | | 217 | 273 | -56 |
| 1989-06-08 | vs BOS | 57 | W 8-7 | 27-30 | 3 | 28,329 | Clay Parker | Mike Boddicker | Lance McCullers | Bob Stanley | | 225 | 280 | -55 |
| 1989-06-10 | vs BOS | 58 | L 8-14 | 27-31 | 5 | 49,348 | Richard Dotson | Roger Clemens | Roger Clemens | Richard Dotson | | 233 | 294 | -61 |
| 1989-06-11 | vs BOS | 59 | W 4-2 | 29-31 | 3 | 0 | Andy Hawkins | Joe Price | Andy Hawkins | Joe Price | Dave Righetti | 237 | 296 | -59 |
| 1989-06-11 | vs BOS | 60 | W 8-7 | 29-31 | 3 | 54,525 | Jimmy Jones | Mike Smithson | Scott Nielsen | Rob Murphy | Lee Guetterman | 245 | 303 | -58 |
| 1989-06-13 | @ BAL | 61 | L 2-5 | 29-32 | 3 | 24,674 | Dave LaPoint | Dave J. Schmidt | Dave J. Schmidt | Dave LaPoint | Gregg Olson | 247 | 308 | -61 |
| 1989-06-14 | @ BAL | 62 | W 2-1 | 30-32 | 2 | 28,626 | Chuck Cary | Bob Milacki | Lee Guetterman | Kevin Hickey | Dave Righetti | 249 | 309 | -60 |
| 1989-06-15 | @ BAL | 63 | L 2-3 | 30-33 | 2 | 30,284 | Richard Dotson | Jeff Ballard | Mark Thurmond | Lance McCullers | | 251 | 312 | -61 |
| 1989-06-16 | vs TEX | 64 | W 8-3 | 32-33 | 2 | 0 | Andy Hawkins | Bobby Witt | Andy Hawkins | Bobby Witt | | 259 | 315 | -56 |
| 1989-06-16 | vs TEX | 65 | W 6-1 | 32-33 | 2 | 28,372 | Jimmy Jones | Kevin Brown | Jimmy Jones | Kevin Brown | | 265 | 316 | -51 |
| 1989-06-17 | vs TEX | 66 | W 5-3 | 33-33 | 2 | 38,917 | Dave Eiland | Mike Jeffcoat | Dave Eiland | Mike Jeffcoat | Dave Righetti | 270 | 319 | -49 |
| 1989-06-18 | vs TEX | 67 | L 2-5 | 33-34 | 3 | 42,825 | Dave LaPoint | Charlie Hough | Charlie Hough | Dave LaPoint | | 272 | 324 | -52 |
| 1989-06-20 | vs CHA | 68 | L 6-13 | 33-35 | 4 | 20,750 | Richard Dotson | Jerry Reuss | Jerry Reuss | Richard Dotson | John Davis | 278 | 337 | -59 |
| 1989-06-21 | vs CHA | 69 | L 3-7 | 33-36 | 5 | 20,404 | Andy Hawkins | Greg Hibbard | Donn Pall | Andy Hawkins | | 281 | 344 | -63 |
| 1989-06-22 | vs CHA | 70 | W 10-7 | 34-36 | 3 | 21,677 | Jimmy Jones | Ken Patterson | Greg Cadaret | Shawn Hillegas | Dave Righetti | 291 | 351 | -60 |
| 1989-06-23 | @ KCA | 71 | L 0-3 | 34-37 | 3 | 39,037 | Dave Eiland | Mark Gubicza | Mark Gubicza | Dave Eiland | | 291 | 354 | -63 |
| 1989-06-24 | @ KCA | 72 | W 12-5 | 35-37 | 3 | 40,589 | Dave LaPoint | Kevin Appier | Lance McCullers | Kevin Appier | | 303 | 359 | -56 |
| 1989-06-25 | @ KCA | 73 | W 5-4 | 36-37 | 2 | 37,514 | Andy Hawkins | Charlie Leibrandt | Andy Hawkins | Charlie Leibrandt | Dave Righetti | 308 | 363 | -55 |
| 1989-06-27 | @ DET | 74 | L 5-6 | 36-38 | 2 | 22,077 | Jimmy Jones | Paul Gibson | Brad Havens | Lee Guetterman | | 313 | 369 | -56 |
| 1989-06-28 | @ DET | 75 | L 5-6 | 36-39 | 3 | 22,256 | Dave Eiland | Doyle Alexander | Mike Henneman | Dave Righetti | | 318 | 375 | -57 |
| 1989-06-29 | @ DET | 76 | W 7-6 | 37-39 | 2 | 22,455 | Dave LaPoint | Frank Tanana | Eric Plunk | Ed Nunez | Dave Righetti | 325 | 381 | -56 |
| 1989-06-30 | vs MIL | 77 | W 4-3 | 38-39 | 2 | 26,374 | Andy Hawkins | Jaime Navarro | Andy Hawkins | Chuck Crim | Dave Righetti | 329 | 384 | -55 |
| 1989-07-01 | vs MIL | 78 | W 5-1 | 39-39 | 2 | 24,851 | Clay Parker | Randy Veres | Clay Parker | Randy Veres | | 334 | 385 | -51 |
| 1989-07-02 | vs MIL | 79 | L 2-10 | 39-40 | 2 | 33,631 | Lance McCullers | Don August | Don August | Lance McCullers | | 336 | 395 | -59 |
| 1989-07-03 | vs MIL | 80 | L 5-8 | 39-41 | 2 | 23,035 | Dave Eiland | Teddy Higuera | Teddy Higuera | Dave Eiland | Dan Plesac | 341 | 403 | -62 |
| 1989-07-04 | vs DET | 81 | W 1-0 | 40-41 | 2 | 32,198 | Don Schulze | Frank Tanana | Don Schulze | Frank Tanana | Lee Guetterman | 342 | 403 | -61 |
| 1989-07-05 | vs DET | 82 | W 9-0 | 41-41 | 2 | 20,206 | Andy Hawkins | Brad Havens | Andy Hawkins | Brad Havens | | 351 | 403 | -52 |
| 1989-07-06 | vs DET | 83 | W 6-5 | 42-41 | 2 | 23,357 | Clay Parker | Charles Hudson | Eric Plunk | Mike Henneman | | 357 | 408 | -51 |
| 1989-07-07 | @ BOS | 84 | L 4-6 | 42-42 | 2 | 33,368 | Greg Cadaret | Roger Clemens | Roger Clemens | Greg Cadaret | Rob Murphy | 361 | 414 | -53 |
| 1989-07-08 | @ BOS | 85 | W 7-5 | 43-42 | 2 | 33,923 | Dave Eiland | Eric Hetzel | Eric Plunk | Mike Smithson | Dave Righetti | 368 | 419 | -51 |
| 1989-07-09 | @ BOS | 86 | L 5-10 | 43-43 | 2 | 33,521 | Don Schulze | John Dopson | Lee Smith | Don Schulze | | 373 | 429 | -56 |
| 1989-07-13 | vs KCA | 87 | W 6-0 | 44-43 | 2 | 24,472 | Andy Hawkins | Mark Gubicza | Andy Hawkins | Mark Gubicza | | 379 | 429 | -50 |
| 1989-07-14 | vs KCA | 88 | L 5-14 | 45-44 | 3 | 0 | Dave Eiland | Bret Saberhagen | Bret Saberhagen | Dave Eiland | | 384 | 443 | -59 |
| 1989-07-14 | vs KCA | 89 | W 9-7 | 45-44 | 3 | 40,672 | Clay Parker | Charlie Leibrandt | Lee Guetterman | Steve Farr | | 393 | 450 | -57 |
| 1989-07-15 | vs KCA | 90 | L 1-7 | 45-45 | 3 | 50,124 | Chuck Cary | Luis Aquino | Luis Aquino | Lee Guetterman | | 394 | 457 | -63 |
| 1989-07-16 | vs KCA | 91 | W 10-1 | 46-45 | 2 | 38,117 | Greg Cadaret | Terry Leach | Greg Cadaret | Terry Leach | | 404 | 458 | -54 |
| 1989-07-17 | @ CHA | 92 | L 3-7 | 46-46 | 2 | 18,070 | Dave LaPoint | Steve Rosenberg | Steve Rosenberg | Dave LaPoint | Shawn Hillegas | 407 | 465 | -58 |
| 1989-07-19 | @ CHA | 93 | L 5-11 | 46-47 | 2 | 16,015 | Clay Parker | Greg Hibbard | Shawn Hillegas | Lee Guetterman | Bobby Thigpen | 412 | 476 | -64 |
| 1989-07-20 | @ TEX | 94 | L 2-6 | 46-48 | 2 | 32,202 | Andy Hawkins | Nolan Ryan | Nolan Ryan | Andy Hawkins | Kenny Rogers | 414 | 482 | -68 |
| 1989-07-21 | @ TEX | 95 | L 2-5 | 46-49 | 3 | 35,665 | Greg Cadaret | Kevin Brown | Kevin Brown | Greg Cadaret | | 416 | 487 | -71 |
| 1989-07-22 | @ TEX | 96 | L 1-2 | 46-50 | 4 | 41,647 | Dave LaPoint | Mike Jeffcoat | Mike Jeffcoat | Dave LaPoint | Jeff Russell | 417 | 489 | -72 |
| 1989-07-23 | @ TEX | 97 | L 4-5 | 46-51 | 5 | 27,039 | Chuck Cary | Bobby Witt | Bobby Witt | Dave Righetti | | 421 | 494 | -73 |
| 1989-07-24 | @ CLE | 98 | L 3-7 | 46-52 | 6 | 23,794 | Clay Parker | John Farrell | John Farrell | Lee Guetterman | | 424 | 501 | -77 |
| 1989-07-25 | @ CLE | 99 | W 5-1 | 47-52 | 5 | 40,496 | Andy Hawkins | Greg Swindell | Andy Hawkins | Greg Swindell | | 429 | 502 | -73 |
| 1989-07-26 | @ CLE | 100 | L 7-9 | 47-53 | 6 | 21,374 | Walt Terrell | Scott Bailes | Doug Jones | Lee Guetterman | | 436 | 511 | -75 |
| 1989-07-28 | vs TOR | 101 | L 2-6 | 47-54 | 6 | 37,222 | Dave LaPoint | John Cerutti | John Cerutti | Dave LaPoint | | 438 | 517 | -79 |
| 1989-07-29 | vs TOR | 102 | W 7-2 | 48-54 | 6 | 42,179 | Chuck Cary | Jimmy Key | Chuck Cary | Jimmy Key | | 445 | 519 | -74 |
| 1989-07-30 | vs TOR | 103 | W 7-6 | 49-54 | 6 | 45,107 | Clay Parker | Dave Stieb | Lee Guetterman | Duane Ward | | 452 | 525 | -73 |
| 1989-07-31 | vs TOR | 104 | L 5-6 | 49-55 | 6 | 21,019 | Andy Hawkins | Mike Flanagan | David Wells | Andy Hawkins | Tom Henke | 457 | 531 | -74 |
| 1989-08-01 | vs MIN | 105 | L 4-5 | 49-56 | 6 | 32,710 | Walt Terrell | Shane Rawley | Shane Rawley | Walt Terrell | Jeff Reardon | 461 | 536 | -75 |
| 1989-08-02 | vs MIN | 106 | W 7-6 | 50-57 | 6 | 0 | Dave LaPoint | Roy Smith | Lance McCullers | Gary Wayne | Dave Righetti | 468 | 542 | -74 |
| 1989-08-02 | vs MIN | 107 | L 3-4 | 50-57 | 6 | 35,058 | Greg Cadaret | Mike Dyer | Jeff Reardon | Eric Plunk | | 471 | 546 | -75 |
| 1989-08-03 | vs MIN | 108 | W 8-1 | 51-57 | 6 | 25,244 | Chuck Cary | Rick Aguilera | Chuck Cary | Rick Aguilera | | 479 | 547 | -68 |
| 1989-08-04 | @ TOR | 109 | L 1-2 | 51-58 | 6 | 48,789 | Clay Parker | Dave Stieb | Dave Stieb | Clay Parker | | 480 | 549 | -69 |
| 1989-08-05 | @ TOR | 110 | W 5-4 | 52-58 | 6 | 49,155 | Andy Hawkins | Mike Flanagan | Andy Hawkins | Duane Ward | Dave Righetti | 485 | 553 | -68 |
| 1989-08-06 | @ TOR | 111 | L 5-6 | 52-59 | 6 | 49,025 | Walt Terrell | Todd Stottlemyre | Todd Stottlemyre | Walt Terrell | | 490 | 559 | -69 |
| 1989-08-07 | vs CLE | 112 | W 9-0 | 53-59 | 6 | 21,794 | Greg Cadaret | Scott Bailes | Greg Cadaret | Scott Bailes | | 499 | 559 | -60 |
| 1989-08-08 | vs CLE | 113 | L 1-3 | 53-60 | 6 | 25,192 | Chuck Cary | Tom Candiotti | Tom Candiotti | Chuck Cary | Doug Jones | 500 | 562 | -62 |
| 1989-08-09 | vs CLE | 114 | L 4-7 | 53-61 | 6 | 31,121 | Andy Hawkins | Rod Nichols | Rod Nichols | Andy Hawkins | Steve Olin | 504 | 569 | -65 |
| 1989-08-11 | @ MIN | 115 | W 11-3 | 54-61 | 6 | 40,653 | Walt Terrell | Shane Rawley | Walt Terrell | Shane Rawley | Dave Righetti | 515 | 572 | -57 |
| 1989-08-12 | @ MIN | 116 | L 3-6 | 54-62 | 6 | 43,920 | Greg Cadaret | Roy Smith | Roy Smith | Greg Cadaret | Jeff Reardon | 518 | 578 | -60 |
| 1989-08-13 | @ MIN | 117 | W 9-7 | 55-62 | 6 | 38,797 | Chuck Cary | Rick Aguilera | Lee Guetterman | Jeff Reardon | | 527 | 585 | -58 |
| 1989-08-14 | @ MIL | 118 | L 4-5 | 55-63 | 6 | 22,829 | Andy Hawkins | Jeff Peterek | Tony Fossas | Dave Righetti | | 531 | 590 | -59 |
| 1989-08-15 | @ MIL | 119 | L 0-1 | 55-64 | 6 | 38,829 | Clay Parker | Teddy Higuera | Teddy Higuera | Clay Parker | | 531 | 591 | -60 |
| 1989-08-16 | @ MIL | 120 | L 1-5 | 55-65 | 6 | 41,036 | Walt Terrell | Mark Knudson | Mark Knudson | Walt Terrell | Chuck Crim | 532 | 596 | -64 |
| 1989-08-17 | @ DET | 121 | W 2-1 | 56-65 | 6 | 23,863 | Greg Cadaret | Brian Dubois | Greg Cadaret | Brian Dubois | Dave Righetti | 534 | 597 | -63 |
| 1989-08-18 | @ DET | 122 | L 3-7 | 56-66 | 6 | 30,432 | Chuck Cary | Jeff Robinson | Jeff Robinson | Chuck Cary | | 537 | 604 | -67 |
| 1989-08-19 | @ DET | 123 | L 4-5 | 56-67 | 6 | 30,454 | Andy Hawkins | Jack Morris | Jack Morris | Dave Righetti | | 541 | 609 | -68 |
| 1989-08-20 | @ DET | 124 | L 6-7 | 56-68 | 6 | 33,499 | Clay Parker | Steve Searcy | Ed Nunez | Eric Plunk | Mike Henneman | 547 | 616 | -69 |
| 1989-08-21 | vs BOS | 125 | W 6-4 | 57-68 | 6 | 33,059 | Walt Terrell | Roger Clemens | Walt Terrell | Roger Clemens | Rich Gossage | 553 | 620 | -67 |
| 1989-08-22 | vs BOS | 126 | L 3-4 | 57-69 | 6 | 33,514 | Greg Cadaret | Wes Gardner | Rob Murphy | John Candelaria | Lee Smith | 556 | 624 | -68 |
| 1989-08-23 | vs BOS | 127 | L 1-4 | 57-70 | 6 | 33,663 | Andy Hawkins | Mike Boddicker | Mike Boddicker | Andy Hawkins | Lee Smith | 557 | 628 | -71 |
| 1989-08-24 | vs BAL | 128 | W 5-1 | 58-71 | 6 | 0 | Chuck Cary | Pete Harnisch | Chuck Cary | Pete Harnisch | | 562 | 629 | -67 |
| 1989-08-24 | vs BAL | 129 | L 2-9 | 58-71 | 6 | 30,214 | Eric Plunk | Dave J. Schmidt | Dave J. Schmidt | Eric Plunk | | 564 | 638 | -74 |
| 1989-08-25 | vs BAL | 130 | L 1-3 | 58-72 | 6 | 30,177 | Clay Parker | Jeff Ballard | Jeff Ballard | Clay Parker | Gregg Olson | 565 | 641 | -76 |
| 1989-08-26 | vs BAL | 131 | L 4-6 | 58-73 | 6 | 38,021 | Walt Terrell | Dave Johnson | Dave Johnson | Walt Terrell | Gregg Olson | 569 | 647 | -78 |
| 1989-08-27 | vs BAL | 132 | L 5-8 | 58-74 | 6 | 43,799 | Greg Cadaret | Bob Milacki | Bob Milacki | Greg Cadaret | | 574 | 655 | -81 |
| 1989-08-28 | vs OAK | 133 | L 3-7 | 58-75 | 6 | 25,359 | Andy Hawkins | Dave Stewart | Dave Stewart | Andy Hawkins | Dennis Eckersley | 577 | 662 | -85 |
| 1989-08-29 | vs OAK | 134 | L 5-19 | 58-76 | 6 | 27,751 | Chuck Cary | Storm Davis | Storm Davis | Chuck Cary | | 582 | 681 | -99 |
| 1989-08-30 | vs OAK | 135 | W 8-5 | 59-76 | 6 | 26,238 | Eric Plunk | Mike Moore | Eric Plunk | Mike Moore | Lance McCullers | 590 | 686 | -96 |
| 1989-09-01 | vs CAL | 136 | W 11-5 | 60-76 | 6 | 23,421 | Walt Terrell | Terry Clark | Walt Terrell | Terry Clark | Lee Guetterman | 601 | 691 | -90 |
| 1989-09-02 | vs CAL | 137 | W 2-1 | 61-76 | 6 | 23,508 | Greg Cadaret | Mike Witt | Greg Cadaret | Mike Witt | | 603 | 692 | -89 |
| 1989-09-03 | vs CAL | 138 | W 5-2 | 62-76 | 6 | 40,170 | Andy Hawkins | Bert Blyleven | Andy Hawkins | Bert Blyleven | Lance McCullers | 608 | 694 | -86 |
| 1989-09-04 | vs CAL | 139 | W 2-1 | 63-76 | 6 | 23,191 | Clay Parker | Jim Abbott | Clay Parker | Jim Abbott | Dave Righetti | 610 | 695 | -85 |
| 1989-09-05 | @ SEA | 140 | W 12-2 | 64-76 | 5 | 14,905 | Eric Plunk | Randy Johnson | Eric Plunk | Randy Johnson | | 622 | 697 | -75 |
| 1989-09-06 | @ SEA | 141 | W 5-3 | 65-76 | 5 | 13,364 | Walt Terrell | Brian Holman | Walt Terrell | Brian Holman | Dave Righetti | 627 | 700 | -73 |
| 1989-09-07 | @ SEA | 142 | W 6-4 | 66-76 | 5 | 11,166 | Greg Cadaret | Scott Bankhead | Rich Gossage | Mike Schooler | Dave Righetti | 633 | 704 | -71 |
| 1989-09-08 | @ OAK | 143 | W 5-1 | 67-76 | 5 | 43,626 | Andy Hawkins | Dave Stewart | Dale Mohorcic | Dave Stewart | | 638 | 705 | -67 |
| 1989-09-09 | @ OAK | 144 | L 0-7 | 67-77 | 5 | 43,760 | Clay Parker | Mike Moore | Mike Moore | Clay Parker | | 638 | 712 | -74 |
| 1989-09-10 | @ OAK | 145 | L 2-6 | 67-78 | 5 | 44,071 | Eric Plunk | Storm Davis | Storm Davis | Eric Plunk | | 640 | 718 | -78 |
| 1989-09-12 | @ CAL | 146 | L 6-7 | 67-79 | 5 | 28,260 | Walt Terrell | Mike Witt | Bob McClure | Chuck Cary | | 646 | 725 | -79 |
| 1989-09-13 | @ CAL | 147 | L 3-4 | 67-80 | 5 | 30,670 | Greg Cadaret | Bert Blyleven | Greg Minton | Dave Righetti | | 649 | 729 | -80 |
| 1989-09-15 | vs SEA | 148 | L 1-3 | 67-81 | 6 | 32,044 | Andy Hawkins | Erik Hanson | Erik Hanson | Andy Hawkins | | 650 | 732 | -82 |
| 1989-09-16 | vs SEA | 149 | W 4-1 | 68-81 | 5 | 22,922 | Eric Plunk | Randy Johnson | Eric Plunk | Randy Johnson | Lee Guetterman | 654 | 733 | -79 |
| 1989-09-17 | vs SEA | 150 | L 0-3 | 68-82 | 5 | 35,251 | Walt Terrell | Brian Holman | Brian Holman | Walt Terrell | Mike Schooler | 654 | 736 | -82 |
| 1989-09-21 | vs MIL | 151 | L 1-14 | 69-83 | 5 | 0 | Greg Cadaret | Mark Knudson | Mark Knudson | Greg Cadaret | | 655 | 750 | -95 |
| 1989-09-21 | vs MIL | 152 | W 5-4 | 69-83 | 5 | 11,230 | Andy Hawkins | Jaime Navarro | Lee Guetterman | Dan Plesac | | 660 | 754 | -94 |
| 1989-09-22 | @ BAL | 153 | W 5-4 | 70-83 | 5 | 47,721 | Walt Terrell | Dave Johnson | Walt Terrell | Brian Holton | Dave Righetti | 665 | 758 | -93 |
| 1989-09-23 | @ BAL | 154 | L 2-10 | 70-84 | 5 | 48,308 | Eric Plunk | Bob Milacki | Bob Milacki | Eric Plunk | | 667 | 768 | -101 |
| 1989-09-24 | @ BAL | 155 | W 2-0 | 71-84 | 5 | 51,173 | Chuck Cary | Jeff Ballard | Chuck Cary | Jeff Ballard | Dave Righetti | 669 | 768 | -99 |
| 1989-09-25 | @ BOS | 156 | L 4-7 | 71-85 | 6 | 32,759 | Kevin Mmahat | Roger Clemens | Roger Clemens | Kevin Mmahat | Lee Smith | 673 | 775 | -102 |
| 1989-09-26 | @ BOS | 157 | L 5-9 | 71-86 | 6 | 31,932 | Andy Hawkins | Eric Hetzel | Eric Hetzel | Andy Hawkins | | 678 | 784 | -106 |
| 1989-09-27 | @ BOS | 158 | W 3-0 | 72-86 | 6 | 32,685 | Walt Terrell | John Dopson | Walt Terrell | John Dopson | | 681 | 784 | -103 |
| 1989-09-29 | vs DET | 159 | W 5-1 | 73-86 | 5 | 21,448 | Eric Plunk | Jack Morris | Eric Plunk | Jack Morris | | 686 | 785 | -99 |
| 1989-09-30 | vs DET | 160 | W 9-2 | 74-86 | 5 | 20,313 | Andy Hawkins | Kevin Ritz | Andy Hawkins | Kevin Ritz | Lee Guetterman | 695 | 787 | -92 |
| 1989-10-01 | vs DET | 161 | L 3-5 | 74-87 | 5 | 30,079 | Kevin Mmahat | Frank Tanana | Frank Tanana | Kevin Mmahat | Mike Henneman | 698 | 792 | -94 |