| 1989-04-03 | vs TOR | 1 | L 3-4 | 0-1 | 3 | 38,595 | Mark Gubicza | Jimmy Key | Jimmy Key | Mark Gubicza | Tom Henke | 3 | 4 | -1 |
| 1989-04-05 | vs TOR | 2 | W 2-1 | 1-1 | 4 | 17,126 | Charlie Leibrandt | Dave Stieb | Tom Gordon | Todd Stottlemyre | | 5 | 5 | 0 |
| 1989-04-06 | vs TOR | 3 | W 3-2 | 2-1 | 4 | 18,883 | Bret Saberhagen | Mike Flanagan | Jeff Montgomery | Duane Ward | Steve Farr | 8 | 7 | 1 |
| 1989-04-07 | vs BOS | 4 | W 9-8 | 3-1 | 2 | 21,770 | Floyd Bannister | Oil Can Boyd | Jeff Montgomery | Lee Smith | | 17 | 15 | 2 |
| 1989-04-08 | vs BOS | 5 | W 2-1 | 4-1 | 2 | 28,266 | Mark Gubicza | Roger Clemens | Luis Aquino | Rob Murphy | | 19 | 16 | 3 |
| 1989-04-09 | vs BOS | 6 | L 6-8 | 4-2 | 3 | 25,637 | Charlie Leibrandt | Wes Gardner | John Dopson | Jeff Montgomery | Mike Smithson | 25 | 24 | 1 |
| 1989-04-10 | vs BAL | 7 | W 3-0 | 5-2 | 2 | 17,476 | Bret Saberhagen | Pete Harnisch | Bret Saberhagen | Pete Harnisch | | 28 | 24 | 4 |
| 1989-04-11 | vs BAL | 8 | W 6-5 | 6-2 | 2 | 17,623 | Floyd Bannister | Jose Bautista | Floyd Bannister | Jose Bautista | Steve Farr | 34 | 29 | 5 |
| 1989-04-12 | vs BAL | 9 | L 4-5 | 6-3 | 3 | 20,261 | Mark Gubicza | Bob Milacki | Gregg Olson | Steve Farr | | 38 | 34 | 4 |
| 1989-04-14 | @ TOR | 10 | L 0-3 | 6-4 | 3 | 46,028 | Charlie Leibrandt | Jimmy Key | Jimmy Key | Charlie Leibrandt | | 38 | 37 | 1 |
| 1989-04-15 | @ TOR | 11 | W 10-5 | 7-4 | 2 | 25,247 | Bret Saberhagen | John Cerutti | Luis Aquino | Duane Ward | | 48 | 42 | 6 |
| 1989-04-16 | @ TOR | 12 | L 8-15 | 7-5 | 4 | 35,210 | Floyd Bannister | Dave Stieb | David Wells | Bret Saberhagen | Tony Castillo | 56 | 57 | -1 |
| 1989-04-18 | @ BAL | 13 | W 7-4 | 8-5 | 3 | 13,408 | Mark Gubicza | Bob Milacki | Tom Gordon | Mark Williamson | Steve Farr | 63 | 61 | 2 |
| 1989-04-19 | @ BAL | 14 | L 5-6 | 8-6 | 5 | 15,354 | Charlie Leibrandt | Dave J. Schmidt | Dave J. Schmidt | Charlie Leibrandt | Mark Williamson | 68 | 67 | 1 |
| 1989-04-20 | @ BAL | 15 | L 0-2 | 8-7 | 5 | 22,925 | Bret Saberhagen | Jeff Ballard | Jeff Ballard | Bret Saberhagen | Mark Williamson | 68 | 69 | -1 |
| 1989-04-21 | @ BOS | 16 | W 7-4 | 9-7 | 4 | 31,766 | Floyd Bannister | John Dopson | Floyd Bannister | John Dopson | | 75 | 73 | 2 |
| 1989-04-22 | @ BOS | 17 | W 7-3 | 10-7 | 4 | 33,048 | Mark Gubicza | Mike Boddicker | Mark Gubicza | Mike Boddicker | | 82 | 76 | 6 |
| 1989-04-23 | @ BOS | 18 | W 10-0 | 11-7 | 3 | 33,116 | Charlie Leibrandt | Wes Gardner | Charlie Leibrandt | Wes Gardner | | 92 | 76 | 16 |
| 1989-04-25 | vs NYA | 19 | W 5-3 | 12-7 | 3 | 26,479 | Bret Saberhagen | John Candelaria | Bret Saberhagen | John Candelaria | | 97 | 79 | 18 |
| 1989-04-26 | vs NYA | 20 | W 5-3 | 13-7 | 3 | 26,544 | Floyd Bannister | Al Leiter | Tom Gordon | Al Leiter | Steve Farr | 102 | 82 | 20 |
| 1989-04-27 | vs NYA | 21 | L 2-3 | 13-8 | 3 | 35,173 | Mark Gubicza | Tommy John | Tommy John | Mark Gubicza | Dave Righetti | 104 | 85 | 19 |
| 1989-04-28 | vs MIL | 22 | W 8-1 | 14-8 | 3 | 27,515 | Charlie Leibrandt | Bill Wegman | Charlie Leibrandt | Bill Wegman | | 112 | 86 | 26 |
| 1989-04-29 | vs MIL | 23 | W 4-3 | 15-8 | 3 | 30,475 | Bret Saberhagen | Don August | Tom Gordon | Dan Plesac | | 116 | 89 | 27 |
| 1989-04-30 | vs MIL | 24 | W 2-0 | 16-8 | 3 | 40,113 | Floyd Bannister | Mike Birkbeck | Floyd Bannister | Mike Birkbeck | Steve Farr | 118 | 89 | 29 |
| 1989-05-02 | @ NYA | 25 | W 5-3 | 17-8 | 3 | 20,587 | Mark Gubicza | Tommy John | Mark Gubicza | Tommy John | | 123 | 92 | 31 |
| 1989-05-03 | @ CLE | 26 | L 2-6 | 17-9 | 3 | 8,090 | Charlie Leibrandt | Tom Candiotti | Tom Candiotti | Charlie Leibrandt | | 125 | 98 | 27 |
| 1989-05-04 | @ CLE | 27 | L 1-3 | 17-10 | 3 | 6,757 | Bret Saberhagen | John Farrell | John Farrell | Bret Saberhagen | Doug Jones | 126 | 101 | 25 |
| 1989-05-05 | @ MIL | 28 | W 5-4 | 18-10 | 3 | 16,751 | Floyd Bannister | Mike Birkbeck | Jeff Montgomery | Mark Knudson | Steve Farr | 131 | 105 | 26 |
| 1989-05-06 | @ MIL | 29 | L 0-1 | 18-11 | 4 | 29,692 | Mark Gubicza | Bryan Clutterbuck | Bill Krueger | Tom Gordon | | 131 | 106 | 25 |
| 1989-05-07 | @ MIL | 30 | L 2-8 | 18-12 | 4 | 22,524 | Charlie Leibrandt | Chris Bosio | Chris Bosio | Charlie Leibrandt | Chuck Crim | 133 | 114 | 19 |
| 1989-05-09 | vs CLE | 31 | W 3-1 | 19-12 | 3 | 22,634 | Bret Saberhagen | Tom Candiotti | Bret Saberhagen | Tom Candiotti | | 136 | 115 | 21 |
| 1989-05-10 | vs CLE | 32 | W 3-2 | 20-12 | 3 | 25,983 | Floyd Bannister | John Farrell | Jeff Montgomery | John Farrell | Steve Farr | 139 | 117 | 22 |
| 1989-05-11 | vs TEX | 33 | L 3-6 | 20-13 | 4 | 31,556 | Mark Gubicza | Nolan Ryan | Nolan Ryan | Mark Gubicza | | 142 | 123 | 19 |
| 1989-05-12 | vs TEX | 34 | W 4-3 | 21-13 | 2 | 30,290 | Charlie Leibrandt | Bobby Witt | Charlie Leibrandt | Bobby Witt | Steve Farr | 146 | 126 | 20 |
| 1989-05-13 | vs TEX | 35 | W 4-1 | 22-13 | 2 | 39,163 | Luis Aquino | Jamie Moyer | Luis Aquino | Jamie Moyer | Steve Farr | 150 | 127 | 23 |
| 1989-05-14 | vs TEX | 36 | W 3-2 | 23-13 | 2 | 27,726 | Bret Saberhagen | Kevin Brown | Jeff Montgomery | Cecilio Guante | | 153 | 129 | 24 |
| 1989-05-15 | @ MIN | 37 | W 4-3 | 24-13 | 2 | 18,404 | Floyd Bannister | Roy Smith | Floyd Bannister | Juan Berenguer | Steve Farr | 157 | 132 | 25 |
| 1989-05-16 | @ MIN | 38 | W 8-1 | 25-13 | 1 | 20,657 | Mark Gubicza | Francisco Oliveras | Mark Gubicza | Francisco Oliveras | | 165 | 133 | 32 |
| 1989-05-17 | @ MIN | 39 | L 3-4 | 25-14 | 3 | 20,922 | Charlie Leibrandt | Allan Anderson | Juan Berenguer | Steve Farr | | 168 | 137 | 31 |
| 1989-05-19 | @ DET | 40 | L 0-2 | 25-15 | 3 | 18,208 | Bret Saberhagen | Doyle Alexander | Mike Henneman | Bret Saberhagen | | 168 | 139 | 29 |
| 1989-05-20 | @ DET | 41 | L 1-2 | 25-16 | 3 | 21,287 | Floyd Bannister | Frank Tanana | Mike Henneman | Tom Gordon | | 169 | 141 | 28 |
| 1989-05-21 | @ DET | 42 | L 2-4 | 25-17 | 3 | 24,853 | Mark Gubicza | Paul Gibson | Paul Gibson | Mark Gubicza | Guillermo Hernandez | 171 | 145 | 26 |
| 1989-05-22 | @ TEX | 43 | L 1-4 | 25-18 | 3 | 25,618 | Charlie Leibrandt | Charlie Hough | Charlie Hough | Charlie Leibrandt | Jeff Russell | 172 | 149 | 23 |
| 1989-05-23 | @ TEX | 44 | L 8-10 | 25-19 | 4 | 20,054 | Luis Aquino | Nolan Ryan | Nolan Ryan | Luis Aquino | Jeff Russell | 180 | 159 | 21 |
| 1989-05-24 | @ TEX | 45 | W 6-4 | 26-19 | 3 | 18,905 | Bret Saberhagen | Jamie Moyer | Bret Saberhagen | Jamie Moyer | Tom Gordon | 186 | 163 | 23 |
| 1989-05-26 | vs DET | 46 | W 6-3 | 27-19 | 3 | 27,728 | Floyd Bannister | Paul Gibson | Jeff Montgomery | Mike Henneman | Steve Farr | 192 | 166 | 26 |
| 1989-05-27 | vs DET | 47 | W 5-1 | 28-19 | 3 | 32,705 | Mark Gubicza | Randy Nosek | Mark Gubicza | Randy Nosek | | 197 | 167 | 30 |
| 1989-05-28 | vs DET | 48 | W 9-5 | 29-19 | 3 | 33,610 | Charlie Leibrandt | Mike Trujillo | Tom Gordon | Mike Trujillo | | 206 | 172 | 34 |
| 1989-05-29 | vs MIN | 49 | W 7-1 | 30-19 | 3 | 41,189 | Bret Saberhagen | Frank Viola | Bret Saberhagen | Frank Viola | | 213 | 173 | 40 |
| 1989-05-30 | vs MIN | 50 | L 1-7 | 30-20 | 3 | 24,603 | Stan Clarke | Roy Smith | Roy Smith | Stan Clarke | | 214 | 180 | 34 |
| 1989-05-31 | vs MIN | 51 | L 1-7 | 30-21 | 3 | 23,114 | Floyd Bannister | Francisco Oliveras | Francisco Oliveras | Floyd Bannister | | 215 | 187 | 28 |
| 1989-06-02 | @ CAL | 52 | W 4-0 | 31-21 | 3 | 32,493 | Mark Gubicza | Chuck Finley | Mark Gubicza | Chuck Finley | | 219 | 187 | 32 |
| 1989-06-03 | @ CAL | 53 | L 3-4 | 31-22 | 3 | 50,640 | Charlie Leibrandt | Kirk McCaskill | Kirk McCaskill | Charlie Leibrandt | Bob McClure | 222 | 191 | 31 |
| 1989-06-04 | @ CAL | 54 | L 1-5 | 31-23 | 3 | 47,880 | Kevin Appier | Bert Blyleven | Bert Blyleven | Kevin Appier | | 223 | 196 | 27 |
| 1989-06-05 | @ SEA | 55 | W 5-3 | 32-23 | 3 | 17,429 | Floyd Bannister | Brian Holman | Tom Gordon | Tom Niedenfuer | | 228 | 199 | 29 |
| 1989-06-06 | @ SEA | 56 | L 2-5 | 32-24 | 3 | 10,171 | Stan Clarke | Scott Bankhead | Scott Bankhead | Stan Clarke | | 230 | 204 | 26 |
| 1989-06-07 | @ SEA | 57 | W 9-6 | 33-24 | 3 | 10,925 | Mark Gubicza | Bill Swift | Mark Gubicza | Bill Swift | Jeff Montgomery | 239 | 210 | 29 |
| 1989-06-09 | vs CAL | 58 | W 6-1 | 34-24 | 3 | 34,124 | Charlie Leibrandt | Kirk McCaskill | Charlie Leibrandt | Kirk McCaskill | | 245 | 211 | 34 |
| 1989-06-10 | vs CAL | 59 | W 5-4 | 35-24 | 3 | 36,949 | Bret Saberhagen | Bert Blyleven | Tom Gordon | Greg Minton | Steve Farr | 250 | 215 | 35 |
| 1989-06-11 | vs CAL | 60 | W 5-3 | 36-24 | 3 | 30,942 | Floyd Bannister | Jim Abbott | Terry Leach | Jim Abbott | Steve Farr | 255 | 218 | 37 |
| 1989-06-12 | vs OAK | 61 | W 2-1 | 37-24 | 2 | 39,387 | Mark Gubicza | Bob Welch | Tom Gordon | Todd Burns | | 257 | 219 | 38 |
| 1989-06-13 | vs OAK | 62 | W 5-3 | 38-24 | 2 | 29,816 | Kevin Appier | Curt Young | Kevin Appier | Curt Young | Steve Farr | 262 | 222 | 40 |
| 1989-06-14 | vs OAK | 63 | L 1-2 | 38-25 | 2 | 31,087 | Charlie Leibrandt | Dave Stewart | Dave Stewart | Charlie Leibrandt | Rick Honeycutt | 263 | 224 | 39 |
| 1989-06-15 | @ CLE | 64 | W 5-4 | 39-25 | 2 | 3,661 | Bret Saberhagen | John Farrell | Bret Saberhagen | Doug Jones | Steve Farr | 268 | 228 | 40 |
| 1989-06-16 | @ CLE | 65 | L 0-1 | 39-26 | 2 | 11,916 | Luis Aquino | Buddy Black | Buddy Black | Terry Leach | | 268 | 229 | 39 |
| 1989-06-17 | @ CLE | 66 | L 3-4 | 39-27 | 3 | 17,040 | Mark Gubicza | Scott Bailes | Scott Bailes | Mark Gubicza | Doug Jones | 271 | 233 | 38 |
| 1989-06-18 | @ CLE | 67 | L 1-4 | 39-28 | 3 | 28,928 | Kevin Appier | Greg Swindell | Greg Swindell | Kevin Appier | | 272 | 237 | 35 |
| 1989-06-20 | @ MIL | 68 | W 8-2 | 40-28 | 2 | 17,185 | Charlie Leibrandt | Jaime Navarro | Tom Gordon | Mark Knudson | | 280 | 239 | 41 |
| 1989-06-21 | @ MIL | 69 | W 6-0 | 41-28 | 2 | 18,086 | Bret Saberhagen | Don August | Bret Saberhagen | Don August | | 286 | 239 | 47 |
| 1989-06-22 | @ MIL | 70 | L 2-3 | 41-29 | 2 | 21,607 | Luis Aquino | Teddy Higuera | Chuck Crim | Steve Farr | | 288 | 242 | 46 |
| 1989-06-23 | vs NYA | 71 | W 3-0 | 42-29 | 2 | 39,037 | Mark Gubicza | Dave Eiland | Mark Gubicza | Dave Eiland | | 291 | 242 | 49 |
| 1989-06-24 | vs NYA | 72 | L 5-12 | 42-30 | 2 | 40,589 | Kevin Appier | Dave LaPoint | Lance McCullers | Kevin Appier | | 296 | 254 | 42 |
| 1989-06-25 | vs NYA | 73 | L 4-5 | 42-31 | 3 | 37,514 | Charlie Leibrandt | Andy Hawkins | Andy Hawkins | Charlie Leibrandt | Dave Righetti | 300 | 259 | 41 |
| 1989-06-27 | vs SEA | 74 | L 0-8 | 42-32 | 3 | 25,164 | Luis Aquino | Brian Holman | Brian Holman | Luis Aquino | | 300 | 267 | 33 |
| 1989-06-28 | vs SEA | 75 | W 12-7 | 43-32 | 3 | 30,037 | Mark Gubicza | Gene Harris | Mark Gubicza | Gene Harris | | 312 | 274 | 38 |
| 1989-06-29 | @ CHA | 76 | L 5-12 | 43-33 | 3 | 11,970 | Bret Saberhagen | Melido Perez | Melido Perez | Terry Leach | | 317 | 286 | 31 |
| 1989-06-30 | @ CHA | 77 | W 6-3 | 44-33 | 3 | 12,464 | Charlie Leibrandt | Jerry Reuss | Charlie Leibrandt | Jerry Reuss | Jeff Montgomery | 323 | 289 | 34 |
| 1989-07-01 | @ CHA | 78 | L 4-6 | 44-34 | 3 | 19,106 | Luis Aquino | Richard Dotson | Shawn Hillegas | Luis Aquino | Bobby Thigpen | 327 | 295 | 32 |
| 1989-07-02 | @ CHA | 79 | L 3-7 | 44-35 | 3 | 16,716 | Kevin Appier | Greg Hibbard | Greg Hibbard | Kevin Appier | Donn Pall | 330 | 302 | 28 |
| 1989-07-03 | @ OAK | 80 | L 0-1 | 44-36 | 3 | 36,763 | Mark Gubicza | Dave Stewart | Dave Stewart | Mark Gubicza | Rick Honeycutt | 330 | 303 | 27 |
| 1989-07-04 | @ OAK | 81 | W 10-1 | 45-36 | 3 | 46,031 | Bret Saberhagen | Matt Young | Bret Saberhagen | Matt Young | | 340 | 304 | 36 |
| 1989-07-05 | @ OAK | 82 | W 12-9 | 46-36 | 3 | 20,791 | Charlie Leibrandt | Bob Welch | Steve Crawford | Rick Honeycutt | | 352 | 313 | 39 |
| 1989-07-06 | @ OAK | 83 | L 1-3 | 46-37 | 3 | 21,985 | Luis Aquino | Mike Moore | Mike Moore | Luis Aquino | Todd Burns | 353 | 316 | 37 |
| 1989-07-07 | vs CHA | 84 | W 4-2 | 47-37 | 3 | 37,464 | Terry Leach | Richard Dotson | Terry Leach | Richard Dotson | Steve Farr | 357 | 318 | 39 |
| 1989-07-08 | vs CHA | 85 | W 4-3 | 48-37 | 3 | 39,869 | Mark Gubicza | Greg Hibbard | Jeff Montgomery | John Davis | | 361 | 321 | 40 |
| 1989-07-09 | vs CHA | 86 | W 5-4 | 49-37 | 3 | 30,456 | Bret Saberhagen | Steve Rosenberg | Tom Gordon | Shawn Hillegas | | 366 | 325 | 41 |
| 1989-07-13 | @ NYA | 87 | L 0-6 | 49-38 | 3 | 24,472 | Mark Gubicza | Andy Hawkins | Andy Hawkins | Mark Gubicza | | 366 | 331 | 35 |
| 1989-07-14 | @ NYA | 88 | W 14-5 | 50-39 | 3 | 0 | Bret Saberhagen | Dave Eiland | Bret Saberhagen | Dave Eiland | | 380 | 336 | 44 |
| 1989-07-14 | @ NYA | 89 | L 7-9 | 50-39 | 3 | 40,672 | Charlie Leibrandt | Clay Parker | Lee Guetterman | Steve Farr | | 387 | 345 | 42 |
| 1989-07-15 | @ NYA | 90 | W 7-1 | 51-39 | 3 | 50,124 | Luis Aquino | Chuck Cary | Luis Aquino | Lee Guetterman | | 394 | 346 | 48 |
| 1989-07-16 | @ NYA | 91 | L 1-10 | 51-40 | 3 | 38,117 | Terry Leach | Greg Cadaret | Greg Cadaret | Terry Leach | | 395 | 356 | 39 |
| 1989-07-17 | vs MIL | 92 | W 3-2 | 52-40 | 3 | 37,961 | Tom Gordon | Tom Filer | Tom Gordon | Tom Filer | Jeff Montgomery | 398 | 358 | 40 |
| 1989-07-18 | vs MIL | 93 | W 9-4 | 53-40 | 3 | 28,358 | Mark Gubicza | Don August | Mark Gubicza | Don August | | 407 | 362 | 45 |
| 1989-07-19 | vs MIL | 94 | L 1-7 | 53-41 | 3 | 29,132 | Charlie Leibrandt | Chris Bosio | Chris Bosio | Charlie Leibrandt | | 408 | 369 | 39 |
| 1989-07-20 | vs CLE | 95 | L 0-4 | 53-42 | 3 | 38,595 | Bret Saberhagen | Greg Swindell | Greg Swindell | Bret Saberhagen | | 408 | 373 | 35 |
| 1989-07-21 | vs CLE | 96 | W 6-1 | 54-42 | 3 | 38,274 | Luis Aquino | Scott Bailes | Luis Aquino | Scott Bailes | Jeff Montgomery | 414 | 374 | 40 |
| 1989-07-22 | vs CLE | 97 | L 0-1 | 54-43 | 3 | 38,606 | Tom Gordon | Tom Candiotti | Tom Candiotti | Tom Gordon | Doug Jones | 414 | 375 | 39 |
| 1989-07-23 | vs CLE | 98 | L 5-17 | 54-44 | 4 | 33,991 | Mark Gubicza | Buddy Black | Buddy Black | Mark Gubicza | | 419 | 392 | 27 |
| 1989-07-25 | @ BOS | 99 | L 0-10 | 54-45 | 3 | 34,944 | Charlie Leibrandt | Mike Boddicker | Mike Boddicker | Charlie Leibrandt | | 419 | 402 | 17 |
| 1989-07-26 | @ BOS | 100 | W 7-4 | 55-45 | 3 | 34,681 | Bret Saberhagen | Eric Hetzel | Bret Saberhagen | Joe Price | Jeff Montgomery | 426 | 406 | 20 |
| 1989-07-27 | @ BOS | 101 | L 2-7 | 55-46 | 4 | 34,223 | Tom Gordon | John Dopson | John Dopson | Tom Gordon | | 428 | 413 | 15 |
| 1989-07-28 | vs BAL | 102 | L 3-4 | 55-47 | 4 | 38,606 | Mark Gubicza | Jeff Ballard | Mark Williamson | Jeff Montgomery | | 431 | 417 | 14 |
| 1989-07-29 | vs BAL | 103 | W 5-0 | 56-47 | 3 | 40,053 | Luis Aquino | Dave J. Schmidt | Luis Aquino | Dave J. Schmidt | | 436 | 417 | 19 |
| 1989-07-30 | vs BAL | 104 | W 7-6 | 57-47 | 3 | 30,208 | Charlie Leibrandt | Mike Smith | Steve Farr | Gregg Olson | Jeff Montgomery | 443 | 423 | 20 |
| 1989-08-01 | @ TOR | 105 | W 2-1 | 58-47 | 3 | 48,528 | Bret Saberhagen | Todd Stottlemyre | Bret Saberhagen | Todd Stottlemyre | | 445 | 424 | 21 |
| 1989-08-02 | @ TOR | 106 | L 0-8 | 58-48 | 3 | 48,765 | Mark Gubicza | John Cerutti | John Cerutti | Mark Gubicza | | 445 | 432 | 13 |
| 1989-08-03 | @ TOR | 107 | W 5-0 | 59-48 | 3 | 48,731 | Tom Gordon | Jimmy Key | Tom Gordon | Jimmy Key | | 450 | 432 | 18 |
| 1989-08-04 | @ MIN | 108 | L 1-5 | 59-49 | 3 | 32,470 | Luis Aquino | Allan Anderson | Allan Anderson | Luis Aquino | | 451 | 437 | 14 |
| 1989-08-05 | @ MIN | 109 | L 4-6 | 59-50 | 3 | 43,130 | Charlie Leibrandt | Mark Guthrie | Juan Berenguer | Steve Farr | Jeff Reardon | 455 | 443 | 12 |
| 1989-08-06 | @ MIN | 110 | W 3-2 | 60-50 | 3 | 35,028 | Bret Saberhagen | Shane Rawley | Bret Saberhagen | Shane Rawley | Jeff Montgomery | 458 | 445 | 13 |
| 1989-08-07 | vs BOS | 111 | W 6-4 | 61-50 | 3 | 40,803 | Mark Gubicza | Wes Gardner | Mark Gubicza | Greg Harris | Steve Farr | 464 | 449 | 15 |
| 1989-08-08 | vs BOS | 112 | W 8-1 | 62-50 | 3 | 32,015 | Tom Gordon | Tom Bolton | Tom Gordon | Tom Bolton | | 472 | 450 | 22 |
| 1989-08-09 | vs BOS | 113 | L 2-6 | 62-51 | 3 | 37,225 | Luis Aquino | Mike Boddicker | Mike Boddicker | Luis Aquino | | 474 | 456 | 18 |
| 1989-08-11 | vs TOR | 114 | W 6-2 | 63-51 | 3 | 40,027 | Bret Saberhagen | Mike Flanagan | Bret Saberhagen | Mike Flanagan | | 480 | 458 | 22 |
| 1989-08-12 | vs TOR | 115 | L 0-2 | 63-52 | 3 | 40,934 | Mark Gubicza | Todd Stottlemyre | Todd Stottlemyre | Mark Gubicza | Tom Henke | 480 | 460 | 20 |
| 1989-08-13 | vs TOR | 116 | W 8-3 | 64-52 | 3 | 33,619 | Tom Gordon | John Cerutti | Tom Gordon | John Cerutti | | 488 | 463 | 25 |
| 1989-08-14 | @ CHA | 117 | L 3-4 | 64-53 | 3 | 10,575 | Luis Aquino | Richard Dotson | Ken Patterson | Luis Aquino | Bobby Thigpen | 491 | 467 | 24 |
| 1989-08-15 | @ CHA | 118 | W 10-6 | 65-53 | 3 | 13,553 | Charlie Leibrandt | Steve Rosenberg | Terry Leach | Tom McCarthy | | 501 | 473 | 28 |
| 1989-08-16 | @ CHA | 119 | W 5-4 | 66-53 | 3 | 11,155 | Bret Saberhagen | Eric King | Bret Saberhagen | Bobby Thigpen | Jeff Montgomery | 506 | 477 | 29 |
| 1989-08-17 | @ SEA | 120 | W 4-2 | 67-53 | 3 | 13,720 | Mark Gubicza | Mike Dunne | Mark Gubicza | Mike Dunne | Jeff Montgomery | 510 | 479 | 31 |
| 1989-08-18 | @ SEA | 121 | W 3-1 | 68-53 | 3 | 16,089 | Tom Gordon | Clint Zavaras | Tom Gordon | Clint Zavaras | Jeff Montgomery | 513 | 480 | 33 |
| 1989-08-19 | @ SEA | 122 | W 13-5 | 69-53 | 3 | 24,592 | Luis Aquino | Randy Johnson | Terry Leach | Randy Johnson | | 526 | 485 | 41 |
| 1989-08-20 | @ SEA | 123 | W 5-4 | 70-53 | 3 | 38,729 | Charlie Leibrandt | Brian Holman | Steve Crawford | Brian Holman | Jeff Montgomery | 531 | 489 | 42 |
| 1989-08-21 | vs CAL | 124 | W 4-2 | 71-53 | 3 | 37,170 | Bret Saberhagen | Chuck Finley | Bret Saberhagen | Willie Fraser | Rick Luecken | 535 | 491 | 44 |
| 1989-08-22 | vs CAL | 125 | W 4-2 | 72-53 | 3 | 27,836 | Mark Gubicza | Mike Witt | Terry Leach | Mike Witt | Jeff Montgomery | 539 | 493 | 46 |
| 1989-08-23 | vs CAL | 126 | W 6-4 | 73-53 | 3 | 32,843 | Tom Gordon | Jim Abbott | Tom Gordon | Jim Abbott | Jeff Montgomery | 545 | 497 | 48 |
| 1989-08-24 | vs CAL | 127 | L 0-5 | 73-54 | 3 | 37,656 | Luis Aquino | Bert Blyleven | Bert Blyleven | Luis Aquino | | 545 | 502 | 43 |
| 1989-08-25 | vs OAK | 128 | W 3-1 | 74-54 | 3 | 38,263 | Mark Gubicza | Mike Moore | Mark Gubicza | Mike Moore | Jeff Montgomery | 548 | 503 | 45 |
| 1989-08-26 | vs OAK | 129 | W 2-0 | 75-54 | 3 | 41,253 | Bret Saberhagen | Curt Young | Bret Saberhagen | Curt Young | | 550 | 503 | 47 |
| 1989-08-27 | vs OAK | 130 | L 0-6 | 75-55 | 3 | 38,263 | Tom Gordon | Bob Welch | Bob Welch | Tom Gordon | | 550 | 509 | 41 |
| 1989-08-29 | vs DET | 131 | W 12-8 | 76-55 | 3 | 21,130 | Luis Aquino | Jack Morris | Steve Crawford | Steve Searcy | | 562 | 517 | 45 |
| 1989-08-30 | vs DET | 132 | W 6-1 | 77-55 | 3 | 20,176 | Mark Gubicza | Doyle Alexander | Mark Gubicza | Doyle Alexander | | 568 | 518 | 50 |
| 1989-08-31 | vs DET | 133 | W 3-0 | 78-55 | 2 | 30,004 | Bret Saberhagen | Kevin Ritz | Bret Saberhagen | Kevin Ritz | Jeff Montgomery | 571 | 518 | 53 |
| 1989-09-01 | @ TEX | 134 | W 5-3 | 79-55 | 2 | 21,036 | Tom Gordon | Charlie Hough | Rick Luecken | Kenny Rogers | Jeff Montgomery | 576 | 521 | 55 |
| 1989-09-02 | @ TEX | 135 | L 3-6 | 79-56 | 2 | 33,550 | Terry Leach | Nolan Ryan | Nolan Ryan | Terry Leach | Jeff Russell | 579 | 527 | 52 |
| 1989-09-03 | @ TEX | 136 | W 13-2 | 80-56 | 2 | 18,144 | Mark Gubicza | Kevin Brown | Mark Gubicza | Kevin Brown | | 592 | 529 | 63 |
| 1989-09-04 | @ DET | 137 | L 1-5 | 80-57 | 2 | 17,412 | Bret Saberhagen | Doyle Alexander | Doyle Alexander | Bret Saberhagen | Mike Henneman | 593 | 534 | 59 |
| 1989-09-05 | @ DET | 138 | L 2-10 | 80-58 | 2 | 12,742 | Tom Gordon | Kevin Ritz | Kevin Ritz | Tom Gordon | | 595 | 544 | 51 |
| 1989-09-06 | @ DET | 139 | L 5-11 | 80-59 | 2 | 12,903 | Charlie Leibrandt | Frank Tanana | Ed Nunez | Charlie Leibrandt | Brian Dubois | 600 | 555 | 45 |
| 1989-09-08 | vs MIN | 140 | W 6-0 | 81-59 | 2 | 28,435 | Mark Gubicza | Roy Smith | Mark Gubicza | Roy Smith | | 606 | 555 | 51 |
| 1989-09-09 | vs MIN | 141 | W 3-1 | 82-59 | 2 | 37,418 | Bret Saberhagen | Rick Aguilera | Bret Saberhagen | Rick Aguilera | Jeff Montgomery | 609 | 556 | 53 |
| 1989-09-10 | vs MIN | 142 | L 2-8 | 82-60 | 2 | 28,853 | Tom Gordon | Allan Anderson | Allan Anderson | Tom Gordon | | 611 | 564 | 47 |
| 1989-09-11 | vs MIN | 143 | W 6-1 | 83-60 | 2 | 23,948 | Larry McWilliams | Mike Dyer | Larry McWilliams | Mike Dyer | | 617 | 565 | 52 |
| 1989-09-12 | vs TEX | 144 | W 6-5 | 84-60 | 2 | 19,477 | Mark Gubicza | Nolan Ryan | Rick Luecken | Kenny Rogers | | 623 | 570 | 53 |
| 1989-09-13 | vs TEX | 145 | W 3-2 | 85-60 | 2 | 20,011 | Bret Saberhagen | Charlie Hough | Bret Saberhagen | Charlie Hough | | 626 | 572 | 54 |
| 1989-09-14 | vs TEX | 146 | L 4-10 | 85-61 | 2 | 25,857 | Tom Gordon | Mike Jeffcoat | Mike Jeffcoat | Tom Gordon | | 630 | 582 | 48 |
| 1989-09-15 | @ BAL | 147 | L 2-5 | 85-62 | 2 | 38,029 | Larry McWilliams | Bob Milacki | Bob Milacki | Steve Crawford | Gregg Olson | 632 | 587 | 45 |
| 1989-09-16 | @ BAL | 148 | L 5-7 | 85-63 | 2 | 44,591 | Mark Gubicza | Jeff Ballard | Gregg Olson | Terry Leach | | 637 | 594 | 43 |
| 1989-09-17 | @ BAL | 149 | W 7-0 | 86-63 | 2 | 42,254 | Bret Saberhagen | Dave Johnson | Bret Saberhagen | Dave Johnson | | 644 | 594 | 50 |
| 1989-09-18 | vs CHA | 150 | L 2-4 | 86-64 | 3 | 23,722 | Tom Gordon | Greg Hibbard | Barry Jones | Jeff Montgomery | Bobby Thigpen | 646 | 598 | 48 |
| 1989-09-19 | vs CHA | 151 | W 5-3 | 87-64 | 3 | 19,748 | Larry McWilliams | Richard Dotson | Larry McWilliams | Richard Dotson | Steve Farr | 651 | 601 | 50 |
| 1989-09-20 | vs CHA | 152 | L 2-7 | 87-65 | 3 | 21,320 | Mark Gubicza | Melido Perez | Melido Perez | Mark Gubicza | | 653 | 608 | 45 |
| 1989-09-22 | vs SEA | 153 | W 9-2 | 88-66 | 3 | 0 | Bret Saberhagen | Brian Holman | Bret Saberhagen | Brian Holman | | 662 | 610 | 52 |
| 1989-09-22 | vs SEA | 154 | L 0-2 | 88-66 | 3 | 29,286 | Tom Gordon | Bill Swift | Bill Swift | Tom Gordon | Mike Schooler | 662 | 612 | 50 |
| 1989-09-23 | vs SEA | 155 | L 0-8 | 88-67 | 3 | 35,102 | Larry McWilliams | Scott Bankhead | Scott Bankhead | Larry McWilliams | | 662 | 620 | 42 |
| 1989-09-24 | vs SEA | 156 | W 4-1 | 89-67 | 2 | 24,518 | Steve Farr | Clint Zavaras | Steve Farr | Clint Zavaras | Jeff Montgomery | 666 | 621 | 45 |
| 1989-09-26 | @ CAL | 157 | W 4-0 | 90-67 | 2 | 26,578 | Bret Saberhagen | Kirk McCaskill | Bret Saberhagen | Kirk McCaskill | | 670 | 621 | 49 |
| 1989-09-27 | @ CAL | 158 | W 8-3 | 91-67 | 2 | 26,894 | Tom Gordon | Jim Abbott | Tom Gordon | Jim Abbott | | 678 | 624 | 54 |
| 1989-09-28 | @ CAL | 159 | L 0-2 | 91-68 | 2 | 25,925 | Larry McWilliams | Bert Blyleven | Bert Blyleven | Larry McWilliams | | 678 | 626 | 52 |
| 1989-09-29 | @ OAK | 160 | L 3-4 | 91-69 | 2 | 43,470 | Steve Farr | Storm Davis | Gene Nelson | Rick Luecken | | 681 | 630 | 51 |
| 1989-09-30 | @ OAK | 161 | W 6-1 | 92-69 | 2 | 42,891 | Bret Saberhagen | Bob Welch | Bret Saberhagen | Todd Burns | | 687 | 631 | 56 |
| 1989-10-01 | @ OAK | 162 | L 3-4 | 92-70 | 2 | 43,755 | Jose De Jesus | Dave Otto | Jim Corsi | Terry Leach | | 690 | 635 | 55 |