| 1988-04-05 | vs CHN | 1 | L 9-10 | 0-1 | 5 | 34,929 | Rick Mahler | Rick Sutcliffe | Mike Bielecki | Jim Acker | | 9 | 10 | -1 |
| 1988-04-06 | vs CHN | 2 | L 0-3 | 0-2 | 5 | 6,122 | Zane Smith | Greg Maddux | Greg Maddux | Zane Smith | | 9 | 13 | -4 |
| 1988-04-07 | vs LAN | 3 | L 2-5 | 0-3 | 5 | 5,257 | Pete Smith | Don Sutton | Alejandro Pena | Paul Assenmacher | Jesse Orosco | 11 | 18 | -7 |
| 1988-04-08 | vs LAN | 4 | L 3-6 | 0-4 | 5 | 10,723 | Kevin Coffman | Tim Leary | Tim Leary | Kevin Coffman | Tim Belcher | 14 | 24 | -10 |
| 1988-04-09 | vs LAN | 5 | L 3-11 | 0-5 | 5 | 16,603 | Tom Glavine | Fernando Valenzuela | Fernando Valenzuela | Tom Glavine | | 17 | 35 | -18 |
| 1988-04-10 | vs LAN | 6 | L 1-3 | 0-6 | 6 | 14,171 | Rick Mahler | Orel Hershiser | Orel Hershiser | Rick Mahler | Jesse Orosco | 18 | 38 | -20 |
| 1988-04-12 | vs HOU | 7 | L 3-8 | 0-7 | 6 | 1,938 | Zane Smith | Nolan Ryan | Nolan Ryan | Zane Smith | | 21 | 46 | -25 |
| 1988-04-13 | vs HOU | 8 | L 0-4 | 0-8 | 6 | 3,810 | Pete Smith | Jim Deshaies | Jim Deshaies | Pete Smith | | 21 | 50 | -29 |
| 1988-04-15 | @ LAN | 9 | L 2-3 | 0-9 | 6 | 41,222 | Tom Glavine | Orel Hershiser | Orel Hershiser | Tom Glavine | | 23 | 53 | -30 |
| 1988-04-16 | @ LAN | 10 | L 4-7 | 0-10 | 6 | 27,114 | Rick Mahler | Tim Belcher | Tim Belcher | Rick Mahler | Alejandro Pena | 27 | 60 | -33 |
| 1988-04-17 | @ LAN | 11 | W 3-1 | 1-10 | 6 | 46,484 | Zane Smith | Don Sutton | Zane Smith | Don Sutton | | 30 | 61 | -31 |
| 1988-04-19 | @ HOU | 12 | W 5-4 | 2-10 | 6 | 13,131 | Pete Smith | Jim Deshaies | Bruce Sutter | Jim Deshaies | Paul Assenmacher | 35 | 65 | -30 |
| 1988-04-20 | @ HOU | 13 | L 0-1 | 2-11 | 6 | 13,383 | Tom Glavine | Mike Scott | Mike Scott | Tom Glavine | | 35 | 66 | -31 |
| 1988-04-21 | @ HOU | 14 | L 0-8 | 2-12 | 6 | 12,491 | Kevin Coffman | Bob Knepper | Bob Knepper | Kevin Coffman | Ernie Camacho | 35 | 74 | -39 |
| 1988-04-22 | vs CIN | 15 | L 0-4 | 2-13 | 6 | 7,280 | Zane Smith | Danny Jackson | Danny Jackson | Zane Smith | | 35 | 78 | -43 |
| 1988-04-24 | vs CIN | 16 | W 4-1 | 3-13 | 6 | 14,372 | Pete Smith | Dennis Rasmussen | Pete Smith | Dennis Rasmussen | Paul Assenmacher | 39 | 79 | -40 |
| 1988-04-26 | vs NYN | 17 | L 4-13 | 3-14 | 6 | 10,405 | Tom Glavine | Dwight Gooden | Dwight Gooden | Jim Acker | | 43 | 92 | -49 |
| 1988-04-27 | vs NYN | 18 | L 2-5 | 3-15 | 6 | 6,928 | Zane Smith | Ron Darling | David Cone | Paul Assenmacher | Roger McDowell | 45 | 97 | -52 |
| 1988-04-30 | @ PHI | 19 | L 5-7 | 3-16 | 6 | 19,138 | Rick Mahler | Don Carman | Don Carman | Rick Mahler | Kent Tekulve | 50 | 104 | -54 |
| 1988-05-01 | @ PHI | 20 | W 9-5 | 4-16 | 6 | 42,491 | Tom Glavine | Shane Rawley | Tom Glavine | Shane Rawley | | 59 | 109 | -50 |
| 1988-05-02 | @ NYN | 21 | W 3-1 | 5-16 | 6 | 20,869 | Zane Smith | Ron Darling | Zane Smith | Ron Darling | | 62 | 110 | -48 |
| 1988-05-03 | @ NYN | 22 | L 0-8 | 5-17 | 6 | 24,532 | Pete Smith | David Cone | David Cone | Pete Smith | | 62 | 118 | -56 |
| 1988-05-04 | @ MON | 23 | W 7-5 | 6-17 | 6 | 10,762 | Kevin Coffman | Dennis Martinez | Kevin Coffman | Dennis Martinez | Bruce Sutter | 69 | 123 | -54 |
| 1988-05-05 | @ MON | 24 | L 1-4 | 6-18 | 6 | 10,686 | Rick Mahler | Bryn Smith | Bryn Smith | Rick Mahler | Jeff Parrett | 70 | 127 | -57 |
| 1988-05-06 | vs PHI | 25 | L 3-7 | 6-19 | 6 | 8,377 | Tom Glavine | Shane Rawley | Shane Rawley | Tom Glavine | | 73 | 134 | -61 |
| 1988-05-07 | vs PHI | 26 | W 6-5 | 7-19 | 6 | 15,578 | Zane Smith | Kevin Gross | Paul Assenmacher | Kent Tekulve | | 79 | 139 | -60 |
| 1988-05-08 | vs PHI | 27 | L 1-5 | 7-20 | 6 | 11,232 | Pete Smith | Bruce Ruffin | Bruce Ruffin | Pete Smith | | 80 | 144 | -64 |
| 1988-05-09 | vs MON | 28 | W 9-8 | 8-20 | 6 | 4,274 | Rick Mahler | Dennis Martinez | Rick Mahler | Dennis Martinez | Bruce Sutter | 89 | 152 | -63 |
| 1988-05-10 | vs MON | 29 | L 1-6 | 8-21 | 6 | 3,679 | Tom Glavine | Bryn Smith | Bryn Smith | Tom Glavine | | 90 | 158 | -68 |
| 1988-05-11 | vs MON | 30 | W 3-2 | 9-21 | 6 | 4,852 | Kevin Coffman | Neal Heaton | Kevin Coffman | Neal Heaton | Bruce Sutter | 93 | 160 | -67 |
| 1988-05-13 | @ SLN | 31 | L 5-7 | 9-22 | 6 | 43,206 | Pete Smith | Jose DeLeon | Jose DeLeon | Pete Smith | Ken Dayley | 98 | 167 | -69 |
| 1988-05-14 | @ SLN | 32 | W 7-5 | 10-22 | 6 | 47,887 | Zane Smith | Cris Carpenter | Rick Mahler | Jose Oquendo | | 105 | 172 | -67 |
| 1988-05-15 | @ SLN | 33 | L 6-7 | 10-23 | 6 | 45,166 | Tom Glavine | Larry McWilliams | Todd Worrell | Bruce Sutter | | 111 | 179 | -68 |
| 1988-05-16 | @ CIN | 34 | L 2-4 | 10-24 | 6 | 17,972 | Kevin Coffman | Tom Browning | Tom Browning | Kevin Coffman | Rob Murphy | 113 | 183 | -70 |
| 1988-05-17 | @ CIN | 35 | W 6-2 | 11-24 | 6 | 20,010 | Rick Mahler | Dennis Rasmussen | Rick Mahler | Dennis Rasmussen | | 119 | 185 | -66 |
| 1988-05-18 | @ CIN | 36 | L 4-8 | 11-25 | 6 | 20,122 | Pete Smith | Ron Robinson | Jose Rijo | Paul Assenmacher | | 123 | 193 | -70 |
| 1988-05-20 | @ PIT | 37 | L 3-10 | 11-26 | 6 | 18,880 | Tom Glavine | Mike Dunne | Mike Dunne | Tom Glavine | | 126 | 203 | -77 |
| 1988-05-21 | @ PIT | 38 | L 3-7 | 11-27 | 6 | 21,211 | Kevin Coffman | Brian Fisher | Brian Fisher | Kevin Coffman | | 129 | 210 | -81 |
| 1988-05-22 | @ PIT | 39 | W 6-4 | 12-27 | 6 | 32,683 | Rick Mahler | Bob Walk | Rick Mahler | Bob Walk | Bruce Sutter | 135 | 214 | -79 |
| 1988-05-24 | @ CHN | 40 | W 3-0 | 13-28 | 6 | 0 | Pete Smith | Jamie Moyer | Jose Alvarez | Jamie Moyer | Bruce Sutter | 138 | 214 | -76 |
| 1988-05-24 | @ CHN | 41 | L 1-2 | 13-28 | 6 | 14,607 | Charlie Puleo | Al Nipper | Al Nipper | Charlie Puleo | Rich Gossage | 139 | 216 | -77 |
| 1988-05-25 | @ CHN | 42 | W 2-1 | 14-28 | 6 | 11,002 | Tom Glavine | Les Lancaster | Rick Mahler | Frank DiPino | Bruce Sutter | 141 | 217 | -76 |
| 1988-05-27 | vs SLN | 43 | L 2-5 | 14-29 | 6 | 15,587 | Zane Smith | Randy O'Neal | Steve Peters | Jose Alvarez | Todd Worrell | 143 | 222 | -79 |
| 1988-05-28 | vs SLN | 44 | W 2-1 | 15-29 | 5 | 21,310 | Rick Mahler | John Tudor | Rick Mahler | John Tudor | Bruce Sutter | 145 | 223 | -78 |
| 1988-05-29 | vs SLN | 45 | L 1-3 | 15-30 | 6 | 34,673 | Kevin Coffman | Jose DeLeon | Jose DeLeon | Kevin Coffman | Ken Dayley | 146 | 226 | -80 |
| 1988-05-30 | vs PIT | 46 | L 2-14 | 15-31 | 6 | 6,893 | Pete Smith | Doug Drabek | Doug Drabek | Pete Smith | | 148 | 240 | -92 |
| 1988-05-31 | vs PIT | 47 | W 11-1 | 16-31 | 6 | 4,483 | Tom Glavine | Mike Dunne | Tom Glavine | Mike Dunne | | 159 | 241 | -82 |
| 1988-06-01 | vs PIT | 48 | W 14-2 | 17-31 | 5 | 6,059 | Rick Mahler | Brian Fisher | Rick Mahler | Brian Fisher | | 173 | 243 | -70 |
| 1988-06-03 | @ SDN | 49 | L 5-7 | 17-32 | 6 | 10,773 | Kevin Coffman | Eric Show | Eric Show | Kevin Coffman | Mark Davis | 178 | 250 | -72 |
| 1988-06-04 | @ SDN | 50 | L 5-6 | 17-33 | 6 | 27,352 | Pete Smith | Jimmy Jones | Ed Whitson | Charlie Puleo | Lance McCullers | 183 | 256 | -73 |
| 1988-06-05 | @ SDN | 51 | W 3-1 | 18-33 | 6 | 14,414 | Tom Glavine | Andy Hawkins | Tom Glavine | Andy Hawkins | Bruce Sutter | 186 | 257 | -71 |
| 1988-06-07 | @ SFN | 52 | L 0-5 | 18-34 | 6 | 7,737 | Rick Mahler | Kelly Downs | Kelly Downs | Rick Mahler | | 186 | 262 | -76 |
| 1988-06-08 | @ SFN | 53 | W 5-4 | 19-34 | 6 | 8,912 | Kevin Coffman | Mike Krukow | Jose Alvarez | Craig Lefferts | Bruce Sutter | 191 | 266 | -75 |
| 1988-06-09 | @ SFN | 54 | L 4-6 | 19-35 | 6 | 10,486 | Pete Smith | Mike LaCoss | Mike LaCoss | Pete Smith | Scott Garrelts | 195 | 272 | -77 |
| 1988-06-10 | @ HOU | 55 | W 10-3 | 20-35 | 6 | 35,601 | Tom Glavine | Jim Deshaies | Juan Eichelberger | Dave Smith | | 205 | 275 | -70 |
| 1988-06-11 | @ HOU | 56 | L 4-5 | 20-36 | 6 | 32,459 | Zane Smith | Bob Knepper | Dave Smith | Charlie Puleo | | 209 | 280 | -71 |
| 1988-06-12 | @ HOU | 57 | L 0-5 | 20-37 | 6 | 31,778 | Rick Mahler | Mike Scott | Mike Scott | Rick Mahler | | 209 | 285 | -76 |
| 1988-06-13 | @ HOU | 58 | L 5-6 | 20-38 | 6 | 21,485 | Kevin Coffman | Nolan Ryan | Juan Agosto | Jose Alvarez | Dave Smith | 214 | 291 | -77 |
| 1988-06-14 | vs LAN | 59 | L 4-5 | 20-39 | 6 | 11,136 | Pete Smith | Fernando Valenzuela | Fernando Valenzuela | Pete Smith | Jay Howell | 218 | 296 | -78 |
| 1988-06-15 | vs LAN | 60 | L 5-7 | 20-40 | 6 | 10,154 | Tom Glavine | Orel Hershiser | Orel Hershiser | Tom Glavine | Alejandro Pena | 223 | 303 | -80 |
| 1988-06-16 | vs LAN | 61 | W 9-2 | 21-40 | 6 | 9,666 | Zane Smith | Ken Howell | Zane Smith | Ken Howell | | 232 | 305 | -73 |
| 1988-06-17 | vs HOU | 62 | W 4-3 | 23-40 | 6 | 0 | Rick Mahler | Bob Knepper | Paul Assenmacher | Larry Andersen | Bruce Sutter | 236 | 308 | -72 |
| 1988-06-17 | vs HOU | 63 | W 6-5 | 23-40 | 6 | 12,878 | Charlie Puleo | Joaquin Andujar | Juan Eichelberger | Dave Smith | | 242 | 313 | -71 |
| 1988-06-18 | vs HOU | 64 | L 7-14 | 23-41 | 6 | 17,437 | Kevin Coffman | Nolan Ryan | Juan Agosto | Paul Assenmacher | Larry Andersen | 249 | 327 | -78 |
| 1988-06-19 | vs HOU | 65 | L 4-6 | 23-42 | 6 | 9,750 | Pete Smith | Danny Darwin | Rocky Childress | Bruce Sutter | Dave Smith | 253 | 333 | -80 |
| 1988-06-20 | @ LAN | 66 | L 3-7 | 23-43 | 6 | 43,268 | Tom Glavine | Shawn Hillegas | Shawn Hillegas | Tom Glavine | Alejandro Pena | 256 | 340 | -84 |
| 1988-06-21 | @ LAN | 67 | L 1-2 | 23-44 | 6 | 18,485 | Zane Smith | Tim Leary | Tim Leary | Zane Smith | | 257 | 342 | -85 |
| 1988-06-22 | @ LAN | 68 | W 4-1 | 24-44 | 6 | 27,878 | Rick Mahler | Don Sutton | Rick Mahler | Don Sutton | | 261 | 343 | -82 |
| 1988-06-24 | vs SDN | 69 | W 4-3 | 25-44 | 6 | 9,137 | Pete Smith | Eric Show | Pete Smith | Eric Show | Bruce Sutter | 265 | 346 | -81 |
| 1988-06-25 | vs SDN | 70 | W 8-4 | 26-44 | 6 | 12,315 | Tom Glavine | Jimmy Jones | Charlie Puleo | Jimmy Jones | | 273 | 350 | -77 |
| 1988-06-26 | vs SDN | 71 | L 1-2 | 26-45 | 6 | 7,301 | Zane Smith | Andy Hawkins | Andy Hawkins | Zane Smith | Mark Davis | 274 | 352 | -78 |
| 1988-06-27 | vs SFN | 72 | L 9-10 | 26-46 | 6 | 5,972 | Rick Mahler | Rick Reuschel | Atlee Hammaker | Rick Mahler | Scott Garrelts | 283 | 362 | -79 |
| 1988-06-28 | vs SFN | 73 | L 7-13 | 26-47 | 6 | 8,229 | German Jimenez | Kelly Downs | Kelly Downs | German Jimenez | Craig Lefferts | 290 | 375 | -85 |
| 1988-06-29 | vs SFN | 74 | L 2-7 | 26-48 | 6 | 6,525 | Pete Smith | Don Robinson | Don Robinson | Pete Smith | Scott Garrelts | 292 | 382 | -90 |
| 1988-06-30 | @ MON | 75 | L 0-6 | 26-49 | 6 | 10,461 | Tom Glavine | Brian Holman | Brian Holman | Tom Glavine | | 292 | 388 | -96 |
| 1988-07-01 | @ MON | 76 | L 3-9 | 26-50 | 6 | 20,123 | Zane Smith | Pascual Perez | Pascual Perez | Zane Smith | Joe Hesketh | 295 | 397 | -102 |
| 1988-07-02 | @ MON | 77 | W 5-4 | 27-50 | 6 | 15,797 | Rick Mahler | Bryn Smith | Paul Assenmacher | Neal Heaton | Charlie Puleo | 300 | 401 | -101 |
| 1988-07-03 | @ MON | 78 | L 2-9 | 27-51 | 6 | 25,753 | German Jimenez | John Dopson | John Dopson | German Jimenez | | 302 | 410 | -108 |
| 1988-07-04 | vs PHI | 79 | W 7-0 | 28-51 | 6 | 23,921 | Pete Smith | Don Carman | Pete Smith | Don Carman | | 309 | 410 | -101 |
| 1988-07-05 | vs PHI | 80 | W 10-5 | 29-51 | 6 | 5,471 | Tom Glavine | Mike Maddux | Jose Alvarez | Bruce Ruffin | | 319 | 415 | -96 |
| 1988-07-06 | vs PHI | 81 | W 3-2 | 30-51 | 6 | 6,537 | Zane Smith | Shane Rawley | Zane Smith | Shane Rawley | Bruce Sutter | 322 | 417 | -95 |
| 1988-07-08 | vs MON | 82 | L 1-7 | 30-52 | 6 | 11,548 | Rick Mahler | Bryn Smith | Bryn Smith | Rick Mahler | | 323 | 424 | -101 |
| 1988-07-09 | vs MON | 83 | L 4-9 | 30-53 | 6 | 16,747 | Pete Smith | Dennis Martinez | Dennis Martinez | Pete Smith | | 327 | 433 | -106 |
| 1988-07-10 | vs MON | 84 | L 2-4 | 30-54 | 6 | 23,333 | Tom Glavine | Brian Holman | Jeff Parrett | Bruce Sutter | Neal Heaton | 329 | 437 | -108 |
| 1988-07-14 | vs NYN | 85 | L 8-9 | 30-55 | 6 | 11,805 | Rick Mahler | Ron Darling | Terry Leach | Jose Alvarez | Randy Myers | 337 | 446 | -109 |
| 1988-07-15 | vs NYN | 86 | W 4-3 | 31-55 | 6 | 18,048 | Zane Smith | David Cone | Paul Assenmacher | Randy Myers | | 341 | 449 | -108 |
| 1988-07-16 | vs NYN | 87 | L 2-3 | 31-56 | 6 | 32,208 | Pete Smith | Dwight Gooden | Ed Nunez | Paul Assenmacher | Roger McDowell | 343 | 452 | -109 |
| 1988-07-17 | vs NYN | 88 | L 2-4 | 31-57 | 6 | 15,711 | Tom Glavine | Bob Ojeda | Bob Ojeda | Tom Glavine | Roger McDowell | 345 | 456 | -111 |
| 1988-07-18 | @ PHI | 89 | W 9-8 | 32-58 | 6 | 0 | Rick Mahler | Shane Rawley | Charlie Puleo | Bruce Ruffin | | 354 | 464 | -110 |
| 1988-07-18 | @ PHI | 90 | L 1-4 | 32-58 | 6 | 22,066 | German Jimenez | David Palmer | David Palmer | German Jimenez | Steve Bedrosian | 355 | 468 | -113 |
| 1988-07-19 | @ PHI | 91 | L 4-6 | 32-59 | 6 | 19,735 | Zane Smith | Kevin Gross | Kevin Gross | Zane Smith | Steve Bedrosian | 359 | 474 | -115 |
| 1988-07-20 | @ PHI | 92 | L 3-4 | 32-60 | 6 | 17,747 | Pete Smith | Don Carman | Don Carman | Pete Smith | Steve Bedrosian | 362 | 478 | -116 |
| 1988-07-22 | @ NYN | 93 | L 1-6 | 32-62 | 6 | 0 | Tom Glavine | Dwight Gooden | Dwight Gooden | Tom Glavine | | 363 | 484 | -121 |
| 1988-07-22 | @ NYN | 94 | L 1-5 | 32-62 | 6 | 37,284 | Rick Mahler | David Cone | David Cone | Rick Mahler | | 364 | 489 | -125 |
| 1988-07-23 | @ NYN | 95 | W 6-1 | 33-62 | 6 | 43,637 | John Smoltz | Bob Ojeda | John Smoltz | Bob Ojeda | | 370 | 490 | -120 |
| 1988-07-24 | @ NYN | 96 | W 4-2 | 34-62 | 6 | 46,057 | German Jimenez | Sid Fernandez | German Jimenez | Sid Fernandez | Paul Assenmacher | 374 | 492 | -118 |
| 1988-07-26 | vs CIN | 97 | L 2-3 | 35-63 | 6 | 0 | Pete Smith | Tom Browning | Tom Browning | Pete Smith | John Franco | 376 | 495 | -119 |
| 1988-07-26 | vs CIN | 98 | W 2-1 | 35-63 | 6 | 13,727 | Rick Mahler | Tim Birtsas | Paul Assenmacher | Rob Murphy | | 378 | 496 | -118 |
| 1988-07-27 | vs CIN | 99 | L 2-3 | 35-64 | 6 | 10,419 | Tom Glavine | Danny Jackson | Danny Jackson | Jose Alvarez | John Franco | 380 | 499 | -119 |
| 1988-07-28 | vs CIN | 100 | L 2-5 | 35-65 | 6 | 12,539 | John Smoltz | Jose Rijo | Frank Williams | John Smoltz | John Franco | 382 | 504 | -122 |
| 1988-07-29 | @ SFN | 101 | L 3-5 | 35-66 | 6 | 12,810 | Zane Smith | Rick Reuschel | Rick Reuschel | Zane Smith | | 385 | 509 | -124 |
| 1988-07-30 | @ SFN | 102 | L 1-2 | 35-67 | 6 | 36,289 | Rick Mahler | Kelly Downs | Kelly Downs | Rick Mahler | Craig Lefferts | 386 | 511 | -125 |
| 1988-07-31 | @ SFN | 103 | L 2-4 | 35-69 | 6 | 0 | Pete Smith | Terry Mulholland | Randy Bockus | Jose Alvarez | Scott Garrelts | 388 | 515 | -127 |
| 1988-07-31 | @ SFN | 104 | L 2-3 | 35-69 | 6 | 26,960 | German Jimenez | Don Robinson | Scott Garrelts | Paul Assenmacher | | 390 | 518 | -128 |
| 1988-08-01 | @ SDN | 105 | L 3-6 | 35-70 | 6 | 9,971 | Tom Glavine | Ed Whitson | Ed Whitson | Tom Glavine | Dave Leiper | 393 | 524 | -131 |
| 1988-08-02 | @ SDN | 106 | L 1-4 | 35-71 | 6 | 11,298 | John Smoltz | Eric Show | Eric Show | John Smoltz | | 394 | 528 | -134 |
| 1988-08-03 | @ SDN | 107 | W 4-2 | 36-71 | 6 | 15,061 | Zane Smith | Andy Hawkins | Zane Smith | Andy Hawkins | | 398 | 530 | -132 |
| 1988-08-05 | vs SFN | 108 | W 8-5 | 37-71 | 6 | 17,276 | Rick Mahler | Don Robinson | Rick Mahler | Don Robinson | Joe Boever | 406 | 535 | -129 |
| 1988-08-06 | vs SFN | 109 | W 7-2 | 38-71 | 6 | 24,107 | Pete Smith | Atlee Hammaker | Pete Smith | Atlee Hammaker | Jose Alvarez | 413 | 537 | -124 |
| 1988-08-07 | vs SFN | 110 | L 4-14 | 38-72 | 6 | 12,093 | Tom Glavine | Rick Reuschel | Rick Reuschel | Tom Glavine | | 417 | 551 | -134 |
| 1988-08-08 | vs SFN | 111 | L 2-5 | 38-73 | 6 | 7,705 | John Smoltz | Joe Price | Ron Davis | John Smoltz | Scott Garrelts | 419 | 556 | -137 |
| 1988-08-09 | vs SDN | 112 | L 1-5 | 38-74 | 6 | 6,730 | Zane Smith | Eric Show | Eric Show | Zane Smith | | 420 | 561 | -141 |
| 1988-08-10 | vs SDN | 113 | L 4-5 | 38-75 | 6 | 6,070 | Rick Mahler | Andy Hawkins | Dave Leiper | German Jimenez | | 424 | 566 | -142 |
| 1988-08-11 | vs SDN | 114 | W 2-1 | 39-75 | 6 | 7,053 | Pete Smith | Jimmy Jones | Pete Smith | Jimmy Jones | | 426 | 567 | -141 |
| 1988-08-12 | @ CIN | 115 | W 9-4 | 40-75 | 6 | 27,247 | Tom Glavine | Jack Armstrong | Tom Glavine | Jack Armstrong | | 435 | 571 | -136 |
| 1988-08-13 | @ CIN | 116 | L 1-3 | 40-76 | 6 | 33,193 | Rick Mahler | Danny Jackson | Danny Jackson | Rick Mahler | | 436 | 574 | -138 |
| 1988-08-14 | @ CIN | 117 | L 0-2 | 40-77 | 6 | 38,945 | Zane Smith | Jose Rijo | Tim Birtsas | Zane Smith | John Franco | 436 | 576 | -140 |
| 1988-08-15 | @ PIT | 118 | W 4-3 | 41-77 | 6 | 12,112 | John Smoltz | Bob Walk | Charlie Puleo | Bob Walk | Ed Olwine | 440 | 579 | -139 |
| 1988-08-16 | @ PIT | 119 | L 2-4 | 41-78 | 6 | 13,994 | Pete Smith | Doug Drabek | Doug Drabek | Pete Smith | Jim Gott | 442 | 583 | -141 |
| 1988-08-17 | @ PIT | 120 | L 1-2 | 41-79 | 6 | 33,164 | Tom Glavine | Dave LaPoint | Dave LaPoint | Tom Glavine | Jim Gott | 443 | 585 | -142 |
| 1988-08-19 | @ CHN | 121 | L 7-8 | 41-80 | 6 | 27,912 | Rick Mahler | Greg Maddux | Rich Gossage | Jose Alvarez | | 450 | 593 | -143 |
| 1988-08-20 | @ CHN | 122 | L 4-5 | 41-81 | 6 | 33,325 | Zane Smith | Calvin Schiraldi | Drew Hall | Jim Acker | Jeff Pico | 454 | 598 | -144 |
| 1988-08-21 | @ CHN | 123 | W 1-0 | 42-81 | 6 | 33,097 | Pete Smith | Mike Bielecki | Pete Smith | Mike Bielecki | | 455 | 598 | -143 |
| 1988-08-22 | @ SLN | 124 | W 5-3 | 43-81 | 6 | 23,635 | Tom Glavine | Joe Magrane | Tom Glavine | Joe Magrane | Jose Alvarez | 460 | 601 | -141 |
| 1988-08-23 | @ SLN | 125 | L 0-7 | 43-82 | 6 | 23,806 | John Smoltz | Bob Forsch | Bob Forsch | John Smoltz | | 460 | 608 | -148 |
| 1988-08-24 | @ SLN | 126 | L 3-5 | 43-83 | 6 | 24,997 | Rick Mahler | Jose DeLeon | Todd Worrell | Bruce Sutter | | 463 | 613 | -150 |
| 1988-08-25 | vs CHN | 127 | L 1-6 | 43-84 | 6 | 7,882 | German Jimenez | Calvin Schiraldi | Calvin Schiraldi | German Jimenez | | 464 | 619 | -155 |
| 1988-08-26 | vs CHN | 128 | W 4-0 | 44-84 | 6 | 19,173 | Pete Smith | Rick Sutcliffe | Pete Smith | Rick Sutcliffe | | 468 | 619 | -151 |
| 1988-08-27 | vs CHN | 129 | L 0-5 | 44-85 | 6 | 20,256 | Tom Glavine | Jeff Pico | Jeff Pico | Tom Glavine | | 468 | 624 | -156 |
| 1988-08-28 | vs CHN | 130 | W 4-2 | 45-85 | 6 | 17,377 | John Smoltz | Jamie Moyer | John Smoltz | Jamie Moyer | Paul Assenmacher | 472 | 626 | -154 |
| 1988-08-29 | vs SLN | 131 | L 2-3 | 45-86 | 6 | 6,668 | Rick Mahler | Jose DeLeon | Jose DeLeon | Rick Mahler | John Costello | 474 | 629 | -155 |
| 1988-08-30 | vs SLN | 132 | L 1-9 | 45-87 | 6 | 6,278 | German Jimenez | Greg Mathews | Greg Mathews | German Jimenez | | 475 | 638 | -163 |
| 1988-08-31 | vs SLN | 133 | L 4-6 | 45-88 | 6 | 6,358 | Pete Smith | Scott Terry | Scott Terry | Pete Smith | Todd Worrell | 479 | 644 | -165 |
| 1988-09-02 | vs PIT | 134 | W 2-1 | 46-88 | 6 | 7,938 | Tom Glavine | Bob Walk | Paul Assenmacher | Jim Gott | | 481 | 645 | -164 |
| 1988-09-05 | vs LAN | 135 | L 0-3 | 46-89 | 6 | 10,768 | Rick Mahler | Orel Hershiser | Orel Hershiser | Rick Mahler | | 481 | 648 | -167 |
| 1988-09-06 | vs LAN | 136 | W 2-1 | 47-89 | 6 | 7,245 | Pete Smith | Tim Belcher | Paul Assenmacher | Jesse Orosco | Bruce Sutter | 483 | 649 | -166 |
| 1988-09-07 | @ SFN | 137 | W 4-1 | 48-89 | 6 | 4,910 | Tom Glavine | Jeff Brantley | Tom Glavine | Jeff Brantley | | 487 | 650 | -163 |
| 1988-09-08 | @ SFN | 138 | L 2-3 | 48-90 | 6 | 5,005 | John Smoltz | Don Robinson | Don Robinson | Charlie Puleo | | 489 | 653 | -164 |
| 1988-09-09 | @ SDN | 139 | W 5-4 | 49-90 | 6 | 44,112 | German Jimenez | Jimmy Jones | Jose Alvarez | Mark Davis | Bruce Sutter | 494 | 657 | -163 |
| 1988-09-10 | @ SDN | 140 | L 2-6 | 49-91 | 6 | 15,349 | Rick Mahler | Eric Show | Eric Show | Rick Mahler | | 496 | 663 | -167 |
| 1988-09-11 | @ SDN | 141 | L 2-8 | 49-92 | 6 | 10,089 | Charlie Puleo | Dennis Rasmussen | Dennis Rasmussen | Charlie Puleo | | 498 | 671 | -173 |
| 1988-09-12 | @ LAN | 142 | L 4-5 | 49-93 | 6 | 24,578 | Tom Glavine | Tim Leary | Tim Leary | Tom Glavine | Alejandro Pena | 502 | 676 | -174 |
| 1988-09-13 | @ LAN | 143 | L 0-2 | 49-94 | 6 | 22,758 | John Smoltz | John Tudor | John Tudor | John Smoltz | Jay Howell | 502 | 678 | -176 |
| 1988-09-14 | @ LAN | 144 | L 0-1 | 49-95 | 6 | 42,434 | Rick Mahler | Orel Hershiser | Orel Hershiser | Rick Mahler | | 502 | 679 | -177 |
| 1988-09-17 | vs SDN | 145 | L 4-9 | 50-96 | 6 | 0 | Pete Smith | Eric Show | Eric Show | Pete Smith | Lance McCullers | 506 | 688 | -182 |
| 1988-09-17 | vs SDN | 146 | W 6-3 | 50-96 | 6 | 4,224 | Tom Glavine | Dennis Rasmussen | Tom Glavine | Dennis Rasmussen | Paul Assenmacher | 512 | 691 | -179 |
| 1988-09-18 | vs SDN | 147 | W 6-5 | 51-96 | 6 | 4,837 | John Smoltz | Andy Hawkins | Paul Assenmacher | Mark Davis | | 518 | 696 | -178 |
| 1988-09-19 | vs SFN | 148 | W 4-3 | 52-96 | 6 | 2,351 | Rick Mahler | Trevor Wilson | Jose Alvarez | Joe Price | | 522 | 699 | -177 |
| 1988-09-20 | vs SFN | 149 | L 4-7 | 52-97 | 6 | 3,034 | Kevin Blankenship | Dennis Cook | Roger Samuels | Kevin Blankenship | | 526 | 706 | -180 |
| 1988-09-21 | @ HOU | 150 | L 0-1 | 52-98 | 6 | 7,411 | Pete Smith | Bob Knepper | Bob Knepper | Pete Smith | | 526 | 707 | -181 |
| 1988-09-22 | @ HOU | 151 | L 2-3 | 52-99 | 6 | 19,633 | Tom Glavine | Jim Deshaies | Jim Deshaies | Tom Glavine | Dave Smith | 528 | 710 | -182 |
| 1988-09-23 | vs CIN | 152 | L 4-5 | 52-100 | 6 | 10,223 | John Smoltz | Jose Rijo | Randy St. Claire | John Smoltz | John Franco | 532 | 715 | -183 |
| 1988-09-24 | vs CIN | 153 | L 1-2 | 52-101 | 6 | 21,098 | Rick Mahler | Danny Jackson | Danny Jackson | Rick Mahler | | 533 | 717 | -184 |
| 1988-09-25 | vs CIN | 154 | L 1-2 | 52-102 | 6 | 7,622 | Kevin Blankenship | Norm Charlton | Norm Charlton | Paul Assenmacher | John Franco | 534 | 719 | -185 |
| 1988-09-27 | vs HOU | 155 | L 2-3 | 52-103 | 6 | 3,071 | Pete Smith | Jim Deshaies | Danny Darwin | Joe Boever | | 536 | 722 | -186 |
| 1988-09-28 | vs HOU | 156 | W 4-3 | 53-103 | 6 | 2,822 | Tom Glavine | Bob Knepper | Charlie Puleo | Jeff Heathcock | | 540 | 725 | -185 |
| 1988-09-29 | vs HOU | 157 | L 4-5 | 53-104 | 6 | 5,789 | John Smoltz | Mike Scott | Mike Scott | John Smoltz | Dave Smith | 544 | 730 | -186 |
| 1988-09-30 | @ CIN | 158 | L 7-8 | 53-105 | 6 | 21,222 | Rick Mahler | Tom Browning | John Franco | Joe Boever | | 551 | 738 | -187 |
| 1988-10-01 | @ CIN | 159 | W 4-2 | 54-105 | 6 | 15,180 | German Jimenez | Norm Charlton | Charlie Puleo | Norm Charlton | Jose Alvarez | 555 | 740 | -185 |
| 1988-10-02 | @ CIN | 160 | L 0-1 | 54-106 | 6 | 24,173 | Jim Acker | Keith Brown | Keith Brown | Jim Acker | John Franco | 555 | 741 | -186 |