| 1988-04-04 | vs CLE | 1 | W 4-3 | 1-0 | 3 | 37,613 | Charlie Hough | Tom Candiotti | Charlie Hough | Chris Codiroli | Mitch Williams | 4 | 3 | 1 |
| 1988-04-06 | vs CLE | 2 | L 1-5 | 1-1 | 3 | 13,003 | Bobby Witt | Greg Swindell | Greg Swindell | Bobby Witt | | 5 | 8 | -3 |
| 1988-04-07 | vs CLE | 3 | L 1-4 | 1-2 | 5 | 12,251 | Jose Guzman | John Farrell | John Farrell | Jose Guzman | Chris Codiroli | 6 | 12 | -6 |
| 1988-04-08 | vs BOS | 4 | L 0-4 | 1-3 | 6 | 18,470 | Mike Jeffcoat | Oil Can Boyd | Oil Can Boyd | Mike Jeffcoat | | 6 | 16 | -10 |
| 1988-04-09 | vs BOS | 5 | L 1-2 | 1-4 | 6 | 27,527 | Charlie Hough | Roger Clemens | Roger Clemens | Charlie Hough | Lee Smith | 7 | 18 | -11 |
| 1988-04-10 | vs BOS | 6 | W 4-1 | 2-4 | 6 | 14,024 | Paul Kilgus | Jeff Sellers | Paul Kilgus | Jeff Sellers | Mitch Williams | 11 | 19 | -8 |
| 1988-04-12 | @ DET | 7 | L 1-4 | 2-5 | 7 | 51,504 | Bobby Witt | Frank Tanana | Frank Tanana | Bobby Witt | Mike Henneman | 12 | 23 | -11 |
| 1988-04-14 | @ DET | 8 | W 2-1 | 3-5 | 7 | 11,899 | Jose Guzman | Jack Morris | Jose Guzman | Jack Morris | Mitch Williams | 14 | 24 | -10 |
| 1988-04-15 | @ BOS | 9 | W 3-2 | 4-5 | 5 | 12,369 | Charlie Hough | Jeff Sellers | Charlie Hough | Wes Gardner | | 17 | 26 | -9 |
| 1988-04-16 | @ BOS | 10 | W 2-0 | 5-5 | 4 | 25,936 | Paul Kilgus | Steve Ellsworth | Paul Kilgus | Steve Ellsworth | Mitch Williams | 19 | 26 | -7 |
| 1988-04-17 | @ BOS | 11 | L 2-15 | 5-6 | 5 | 32,243 | Mike Jeffcoat | Bruce Hurst | Bruce Hurst | Mike Jeffcoat | | 21 | 41 | -20 |
| 1988-04-18 | @ BOS | 12 | L 3-4 | 5-7 | 5 | 33,976 | Bobby Witt | Oil Can Boyd | Lee Smith | Mitch Williams | | 24 | 45 | -21 |
| 1988-04-19 | @ CLE | 13 | W 3-0 | 6-7 | 4 | 5,586 | Jose Guzman | Scott Bailes | Jose Guzman | Scott Bailes | Mitch Williams | 27 | 45 | -18 |
| 1988-04-20 | @ CLE | 14 | L 1-2 | 6-8 | 4 | 6,551 | Charlie Hough | Tom Candiotti | Tom Candiotti | Charlie Hough | | 28 | 47 | -19 |
| 1988-04-22 | vs DET | 15 | L 3-5 | 6-9 | 6 | 23,443 | Paul Kilgus | Doyle Alexander | Doyle Alexander | Paul Kilgus | Mike Henneman | 31 | 52 | -21 |
| 1988-04-23 | vs DET | 16 | L 6-7 | 6-10 | 6 | 34,890 | Bobby Witt | Frank Tanana | Frank Tanana | Bobby Witt | Mike Henneman | 37 | 59 | -22 |
| 1988-04-24 | vs DET | 17 | W 4-2 | 7-10 | 5 | 29,543 | Charlie Hough | Jack Morris | Charlie Hough | Jack Morris | Mitch Williams | 41 | 61 | -20 |
| 1988-04-26 | vs MIL | 18 | W 3-1 | 8-10 | 5 | 27,941 | Jose Guzman | Chris Bosio | Jose Guzman | Chris Bosio | | 44 | 62 | -18 |
| 1988-04-27 | vs MIL | 19 | L 3-4 | 8-11 | 5 | 12,216 | Paul Kilgus | Juan Nieves | Juan Nieves | Paul Kilgus | Dan Plesac | 47 | 66 | -19 |
| 1988-04-29 | @ NYA | 20 | L 1-2 | 8-12 | 7 | 20,277 | Charlie Hough | John Candelaria | John Candelaria | Charlie Hough | | 48 | 68 | -20 |
| 1988-04-30 | @ NYA | 21 | L 3-15 | 8-13 | 7 | 21,011 | Bobby Witt | Richard Dotson | Richard Dotson | Bobby Witt | | 51 | 83 | -32 |
| 1988-05-01 | @ NYA | 22 | W 5-1 | 9-13 | 6 | 40,268 | Paul Kilgus | Al Leiter | Paul Kilgus | Al Leiter | Dale Mohorcic | 56 | 84 | -28 |
| 1988-05-02 | @ BAL | 23 | L 4-9 | 9-14 | 7 | 50,402 | Jose Guzman | Jay Tibbs | Jay Tibbs | Jose Guzman | | 60 | 93 | -33 |
| 1988-05-03 | @ BAL | 24 | W 4-2 | 10-14 | 5 | 11,507 | Ray Hayward | Mike Boddicker | Ray Hayward | Mike Boddicker | Dale Mohorcic | 64 | 95 | -31 |
| 1988-05-04 | @ MIL | 25 | L 5-6 | 10-15 | 6 | 7,541 | Charlie Hough | Mike Birkbeck | Mike Birkbeck | Charlie Hough | Dan Plesac | 69 | 101 | -32 |
| 1988-05-05 | @ MIL | 26 | L 1-9 | 10-16 | 6 | 12,387 | Bobby Witt | Bill Wegman | Bill Wegman | Bobby Witt | | 70 | 110 | -40 |
| 1988-05-06 | vs NYA | 27 | W 7-6 | 11-16 | 5 | 25,602 | Paul Kilgus | Al Leiter | Paul Kilgus | Al Leiter | Jose Cecena | 77 | 116 | -39 |
| 1988-05-07 | vs NYA | 28 | W 3-2 | 12-16 | 5 | 33,611 | Jose Guzman | Tommy John | Dale Mohorcic | Cecilio Guante | | 80 | 118 | -38 |
| 1988-05-08 | vs NYA | 29 | W 10-8 | 13-16 | 4 | 21,761 | Ray Hayward | Charles Hudson | Jeff Russell | Steve Shields | Dale Mohorcic | 90 | 126 | -36 |
| 1988-05-10 | vs BAL | 30 | W 13-5 | 14-16 | 4 | 17,869 | Charlie Hough | Mark Thurmond | Charlie Hough | Mark Thurmond | | 103 | 131 | -28 |
| 1988-05-11 | vs BAL | 31 | W 8-0 | 15-16 | 3 | 12,027 | Paul Kilgus | Mark Williamson | Paul Kilgus | Mark Williamson | | 111 | 131 | -20 |
| 1988-05-12 | vs BAL | 32 | W 2-1 | 16-16 | 2 | 9,964 | Jose Guzman | Jose Bautista | Jose Guzman | Jose Bautista | Mitch Williams | 113 | 132 | -19 |
| 1988-05-13 | vs KCA | 33 | W 2-1 | 17-16 | 2 | 21,898 | Ray Hayward | Bret Saberhagen | Ray Hayward | Bret Saberhagen | Mitch Williams | 115 | 133 | -18 |
| 1988-05-14 | vs KCA | 34 | W 6-3 | 18-16 | 2 | 31,251 | Jeff Russell | Charlie Leibrandt | Jeff Russell | Charlie Leibrandt | Mitch Williams | 121 | 136 | -15 |
| 1988-05-15 | vs KCA | 35 | L 4-5 | 18-17 | 3 | 30,438 | Charlie Hough | Mark Gubicza | Mark Gubicza | Charlie Hough | Gene Garber | 125 | 141 | -16 |
| 1988-05-16 | vs KCA | 36 | L 6-7 | 18-18 | 3 | 15,532 | Paul Kilgus | Floyd Bannister | Floyd Bannister | Paul Kilgus | Steve Farr | 131 | 148 | -17 |
| 1988-05-17 | @ TOR | 37 | W 7-6 | 19-18 | 2 | 25,170 | Jose Guzman | Mike Flanagan | Dale Mohorcic | Mark Eichhorn | | 138 | 154 | -16 |
| 1988-05-18 | @ TOR | 38 | W 4-0 | 20-18 | 2 | 25,029 | Ray Hayward | Todd Stottlemyre | Ray Hayward | Todd Stottlemyre | | 142 | 154 | -12 |
| 1988-05-21 | vs MIN | 39 | W 3-0 | 21-18 | 2 | 31,332 | Paul Kilgus | Bert Blyleven | Paul Kilgus | Bert Blyleven | | 145 | 154 | -9 |
| 1988-05-22 | vs MIN | 40 | L 5-15 | 21-20 | 2 | 0 | Charlie Hough | Les Straker | Les Straker | Charlie Hough | | 150 | 169 | -19 |
| 1988-05-22 | vs MIN | 41 | L 2-4 | 21-20 | 2 | 19,018 | Jose Guzman | Frank Viola | Frank Viola | Jose Guzman | Jeff Reardon | 152 | 173 | -21 |
| 1988-05-24 | vs TOR | 42 | L 2-13 | 21-21 | 2 | 26,408 | Ray Hayward | John Cerutti | John Cerutti | Ray Hayward | Tom Henke | 154 | 186 | -32 |
| 1988-05-25 | vs TOR | 43 | W 5-1 | 22-21 | 2 | 13,528 | Jeff Russell | Jim Clancy | Jeff Russell | Jim Clancy | Dale Mohorcic | 159 | 187 | -28 |
| 1988-05-26 | vs TOR | 44 | W 8-7 | 23-21 | 2 | 13,035 | Paul Kilgus | Dave Stieb | Mitch Williams | Tom Henke | | 167 | 194 | -27 |
| 1988-05-27 | @ KCA | 45 | W 3-2 | 24-21 | 2 | 24,045 | Jose Guzman | Floyd Bannister | Jose Guzman | Floyd Bannister | | 170 | 196 | -26 |
| 1988-05-28 | @ KCA | 46 | L 6-8 | 24-22 | 2 | 37,802 | Charlie Hough | Ted Power | Buddy Black | Dale Mohorcic | Jerry Gleaton | 176 | 204 | -28 |
| 1988-05-29 | @ KCA | 47 | L 1-12 | 24-23 | 3 | 31,118 | Ray Hayward | Bret Saberhagen | Bret Saberhagen | Ray Hayward | | 177 | 216 | -39 |
| 1988-05-30 | @ MIN | 48 | W 6-1 | 25-23 | 2 | 40,300 | Jeff Russell | Bert Blyleven | Jeff Russell | Bert Blyleven | | 183 | 217 | -34 |
| 1988-05-31 | @ MIN | 49 | L 6-8 | 25-24 | 3 | 15,151 | Paul Kilgus | Charlie Lea | Juan Berenguer | Dale Mohorcic | Jeff Reardon | 189 | 225 | -36 |
| 1988-06-01 | @ MIN | 50 | L 1-7 | 25-25 | 3 | 22,361 | Jose Guzman | Frank Viola | Frank Viola | Jose Guzman | | 190 | 232 | -42 |
| 1988-06-02 | @ CHA | 51 | W 10-2 | 26-25 | 3 | 8,400 | Charlie Hough | Melido Perez | Charlie Hough | Melido Perez | | 200 | 234 | -34 |
| 1988-06-03 | @ CHA | 52 | W 9-3 | 27-25 | 3 | 11,062 | Ray Hayward | Dave LaPoint | Ray Hayward | Dave LaPoint | | 209 | 237 | -28 |
| 1988-06-04 | @ CHA | 53 | L 8-10 | 27-26 | 3 | 17,101 | Jeff Russell | Jack McDowell | Bobby Thigpen | Dale Mohorcic | | 217 | 247 | -30 |
| 1988-06-05 | @ CHA | 54 | L 4-5 | 27-27 | 3 | 16,399 | Paul Kilgus | Jerry Reuss | Jerry Reuss | Paul Kilgus | Bobby Thigpen | 221 | 252 | -31 |
| 1988-06-06 | vs CAL | 55 | W 6-4 | 28-27 | 3 | 23,469 | Jose Guzman | Willie Fraser | Jose Guzman | Willie Fraser | | 227 | 256 | -29 |
| 1988-06-07 | vs CAL | 56 | L 0-1 | 28-28 | 4 | 22,549 | Charlie Hough | Chuck Finley | Chuck Finley | Charlie Hough | Bryan Harvey | 227 | 257 | -30 |
| 1988-06-08 | vs CAL | 57 | L 2-5 | 28-29 | 4 | 11,879 | Ray Hayward | Mike Witt | Mike Witt | Ray Hayward | Bryan Harvey | 229 | 262 | -33 |
| 1988-06-09 | vs OAK | 58 | W 5-2 | 29-29 | 4 | 31,435 | Jeff Russell | Storm Davis | Jeff Russell | Storm Davis | | 234 | 264 | -30 |
| 1988-06-10 | vs OAK | 59 | L 6-7 | 29-30 | 4 | 24,994 | Paul Kilgus | Bob Welch | Eric Plunk | Mitch Williams | Dennis Eckersley | 240 | 271 | -31 |
| 1988-06-11 | vs OAK | 60 | L 4-13 | 29-31 | 4 | 42,028 | Jose Guzman | Steve Ontiveros | Greg Cadaret | Jose Guzman | | 244 | 284 | -40 |
| 1988-06-12 | vs OAK | 61 | W 3-2 | 30-31 | 4 | 17,867 | Charlie Hough | Dave Stewart | Charlie Hough | Dave Stewart | | 247 | 286 | -39 |
| 1988-06-14 | @ CAL | 62 | L 0-3 | 30-32 | 4 | 23,312 | Ray Hayward | Mike Witt | Mike Witt | Ray Hayward | | 247 | 289 | -42 |
| 1988-06-15 | @ CAL | 63 | W 6-3 | 31-32 | 4 | 23,241 | Jeff Russell | Dan Petry | Jeff Russell | DeWayne Buice | | 253 | 292 | -39 |
| 1988-06-16 | @ CAL | 64 | L 0-3 | 31-33 | 4 | 21,754 | Paul Kilgus | Kirk McCaskill | Kirk McCaskill | Paul Kilgus | | 253 | 295 | -42 |
| 1988-06-17 | @ OAK | 65 | L 6-7 | 31-34 | 4 | 23,372 | Jose Guzman | Dave Stewart | Rick Honeycutt | Dale Mohorcic | | 259 | 302 | -43 |
| 1988-06-18 | @ OAK | 66 | L 1-2 | 31-35 | 4 | 34,449 | Charlie Hough | Todd Burns | Gene Nelson | Dale Mohorcic | | 260 | 304 | -44 |
| 1988-06-19 | @ OAK | 67 | W 5-4 | 32-35 | 4 | 35,133 | Ray Hayward | Storm Davis | Craig McMurtry | Rick Honeycutt | Mitch Williams | 265 | 308 | -43 |
| 1988-06-20 | vs SEA | 68 | W 4-3 | 33-35 | 4 | 20,919 | Jeff Russell | Mark Langston | Jeff Russell | Mike Schooler | | 269 | 311 | -42 |
| 1988-06-21 | vs SEA | 69 | W 6-0 | 34-35 | 4 | 10,918 | Paul Kilgus | Steve Trout | Paul Kilgus | Steve Trout | | 275 | 311 | -36 |
| 1988-06-22 | vs SEA | 70 | L 2-3 | 34-36 | 4 | 24,650 | Jose Guzman | Scott Bankhead | Mike Schooler | Jose Guzman | | 277 | 314 | -37 |
| 1988-06-24 | vs CHA | 71 | W 5-2 | 35-36 | 4 | 16,393 | Charlie Hough | Melido Perez | Charlie Hough | Melido Perez | | 282 | 316 | -34 |
| 1988-06-25 | vs CHA | 72 | L 5-10 | 35-37 | 4 | 29,259 | Ray Hayward | Dave LaPoint | Dave LaPoint | Ray Hayward | | 287 | 326 | -39 |
| 1988-06-26 | vs CHA | 73 | L 5-7 | 35-38 | 4 | 21,594 | Jeff Russell | Jack McDowell | Jack McDowell | Jeff Russell | Bobby Thigpen | 292 | 333 | -41 |
| 1988-06-27 | @ SEA | 74 | L 3-6 | 35-39 | 4 | 7,591 | Paul Kilgus | Scott Bankhead | Scott Bankhead | Paul Kilgus | Mike Schooler | 295 | 339 | -44 |
| 1988-06-28 | @ SEA | 75 | W 6-0 | 36-39 | 4 | 8,605 | Jose Guzman | Steve Trout | Jose Guzman | Steve Trout | | 301 | 339 | -38 |
| 1988-06-29 | @ SEA | 76 | W 1-0 | 37-39 | 4 | 8,487 | Charlie Hough | Mike Moore | Charlie Hough | Mike Schooler | Mitch Williams | 302 | 339 | -37 |
| 1988-07-01 | vs BAL | 77 | L 1-7 | 37-40 | 4 | 20,396 | Jeff Russell | Mike Boddicker | Mike Boddicker | Jeff Russell | | 303 | 346 | -43 |
| 1988-07-02 | vs BAL | 78 | L 4-7 | 37-41 | 4 | 24,443 | Paul Kilgus | Oswaldo Peraza | John Habyan | Paul Kilgus | Tom Niedenfuer | 307 | 353 | -46 |
| 1988-07-03 | vs BAL | 79 | W 13-1 | 38-41 | 4 | 17,722 | Jose Guzman | Jeff Ballard | Jose Guzman | Jeff Ballard | | 320 | 354 | -34 |
| 1988-07-04 | vs NYA | 80 | L 2-13 | 38-42 | 4 | 41,093 | Charlie Hough | Charles Hudson | Charles Hudson | Charlie Hough | | 322 | 367 | -45 |
| 1988-07-05 | vs NYA | 81 | L 3-5 | 38-43 | 4 | 17,546 | Ray Hayward | Tommy John | Tommy John | Ray Hayward | Tim Stoddard | 325 | 372 | -47 |
| 1988-07-06 | vs NYA | 82 | W 4-2 | 39-43 | 4 | 20,324 | Jeff Russell | Ron Guidry | Jeff Russell | Ron Guidry | Mitch Williams | 329 | 374 | -45 |
| 1988-07-07 | @ BAL | 83 | L 0-6 | 39-44 | 4 | 22,255 | Paul Kilgus | Oswaldo Peraza | Oswaldo Peraza | Paul Kilgus | | 329 | 380 | -51 |
| 1988-07-08 | @ BAL | 84 | W 8-5 | 40-44 | 4 | 22,612 | Jose Guzman | Jeff Ballard | Jose Guzman | Jeff Ballard | Craig McMurtry | 337 | 385 | -48 |
| 1988-07-09 | @ BAL | 85 | L 1-4 | 40-45 | 4 | 21,661 | Charlie Hough | Jay Tibbs | Jay Tibbs | Charlie Hough | Tom Niedenfuer | 338 | 389 | -51 |
| 1988-07-10 | @ BAL | 86 | L 1-2 | 40-46 | 6 | 25,023 | Bobby Witt | Jose Bautista | Jose Bautista | Bobby Witt | Dave J. Schmidt | 339 | 391 | -52 |
| 1988-07-14 | vs MIL | 87 | L 2-6 | 40-47 | 6 | 26,526 | Charlie Hough | Bill Wegman | Bill Wegman | Charlie Hough | Chuck Crim | 341 | 397 | -56 |
| 1988-07-15 | vs MIL | 88 | L 2-4 | 40-48 | 6 | 17,175 | Jose Guzman | Teddy Higuera | Teddy Higuera | Jose Guzman | Dan Plesac | 343 | 401 | -58 |
| 1988-07-16 | vs MIL | 89 | L 3-4 | 40-49 | 6 | 29,742 | Jeff Russell | Don August | Odell Jones | Jeff Russell | Dan Plesac | 346 | 405 | -59 |
| 1988-07-17 | vs MIL | 90 | W 3-0 | 41-49 | 6 | 12,182 | Bobby Witt | Chris Bosio | Bobby Witt | Chris Bosio | | 349 | 405 | -56 |
| 1988-07-18 | @ NYA | 91 | L 2-7 | 41-50 | 6 | 21,449 | Paul Kilgus | Richard Dotson | Richard Dotson | Paul Kilgus | | 351 | 412 | -61 |
| 1988-07-19 | @ NYA | 92 | W 7-2 | 42-50 | 6 | 27,456 | Charlie Hough | John Candelaria | Charlie Hough | John Candelaria | | 358 | 414 | -56 |
| 1988-07-21 | @ MIL | 93 | L 1-6 | 42-51 | 6 | 17,649 | Jose Guzman | Don August | Don August | Jose Guzman | | 359 | 420 | -61 |
| 1988-07-22 | @ MIL | 94 | L 1-2 | 42-52 | 6 | 37,434 | Jeff Russell | Chris Bosio | Chuck Crim | Mitch Williams | | 360 | 422 | -62 |
| 1988-07-23 | @ MIL | 95 | W 7-4 | 43-52 | 5 | 47,779 | Bobby Witt | Mike Birkbeck | Bobby Witt | Chuck Crim | | 367 | 426 | -59 |
| 1988-07-24 | @ MIL | 96 | W 6-4 | 44-52 | 5 | 35,080 | Paul Kilgus | Bill Wegman | Paul Kilgus | Bill Wegman | Mitch Williams | 373 | 430 | -57 |
| 1988-07-25 | vs BOS | 97 | L 0-2 | 44-53 | 5 | 34,175 | Charlie Hough | Roger Clemens | Roger Clemens | Charlie Hough | | 373 | 432 | -59 |
| 1988-07-26 | vs BOS | 98 | W 9-8 | 45-53 | 5 | 20,456 | Jose Guzman | Oil Can Boyd | Craig McMurtry | Tom Bolton | Mitch Williams | 382 | 440 | -58 |
| 1988-07-27 | vs BOS | 99 | L 7-10 | 45-54 | 6 | 17,639 | Jeff Russell | Wes Gardner | Bob Stanley | Mitch Williams | Lee Smith | 389 | 450 | -61 |
| 1988-07-29 | @ DET | 100 | L 2-3 | 46-55 | 5 | 0 | Paul Kilgus | Frank Tanana | Frank Tanana | Craig McMurtry | | 391 | 453 | -62 |
| 1988-07-29 | @ DET | 101 | W 2-1 | 46-55 | 5 | 31,627 | Bobby Witt | Eric King | Bobby Witt | Guillermo Hernandez | | 393 | 454 | -61 |
| 1988-07-30 | @ DET | 102 | L 0-3 | 46-56 | 5 | 36,972 | Charlie Hough | Walt Terrell | Walt Terrell | Charlie Hough | | 393 | 457 | -64 |
| 1988-07-31 | @ DET | 103 | L 1-5 | 46-57 | 5 | 35,977 | Jose Guzman | Jack Morris | Jack Morris | Ed Vande Berg | | 394 | 462 | -68 |
| 1988-08-02 | @ BOS | 104 | L 2-7 | 46-58 | 6 | 35,462 | Jeff Russell | Wes Gardner | Wes Gardner | Jeff Russell | | 396 | 469 | -73 |
| 1988-08-03 | @ BOS | 105 | L 4-5 | 46-59 | 6 | 34,380 | Bobby Witt | Bruce Hurst | Dennis Lamp | Bobby Witt | Lee Smith | 400 | 474 | -74 |
| 1988-08-05 | vs CLE | 106 | W 8-4 | 47-59 | 5 | 21,527 | Paul Kilgus | Rod Nichols | Paul Kilgus | Rod Nichols | Craig McMurtry | 408 | 478 | -70 |
| 1988-08-06 | vs CLE | 107 | L 3-5 | 47-60 | 5 | 31,003 | Charlie Hough | John Farrell | John Farrell | Charlie Hough | Doug Jones | 411 | 483 | -72 |
| 1988-08-07 | vs CLE | 108 | W 2-0 | 48-60 | 5 | 17,089 | Jose Guzman | Rich Yett | Jose Guzman | Rich Yett | | 413 | 483 | -70 |
| 1988-08-08 | vs DET | 109 | L 2-3 | 48-61 | 5 | 22,794 | Jeff Russell | Frank Tanana | Frank Tanana | Jeff Russell | Mike Henneman | 415 | 486 | -71 |
| 1988-08-09 | vs DET | 110 | W 6-2 | 49-61 | 5 | 14,524 | Bobby Witt | Walt Terrell | Bobby Witt | Walt Terrell | | 421 | 488 | -67 |
| 1988-08-10 | vs DET | 111 | L 1-2 | 49-62 | 5 | 15,550 | Paul Kilgus | Jack Morris | Jack Morris | Paul Kilgus | Guillermo Hernandez | 422 | 490 | -68 |
| 1988-08-11 | @ CLE | 112 | W 5-4 | 50-62 | 5 | 10,703 | Charlie Hough | John Farrell | Mitch Williams | Doug Jones | Dale Mohorcic | 427 | 494 | -67 |
| 1988-08-12 | @ CLE | 113 | L 3-6 | 50-63 | 5 | 20,754 | Jose Guzman | Rich Yett | Rich Yett | Jose Guzman | Don Gordon | 430 | 500 | -70 |
| 1988-08-13 | @ CLE | 114 | W 12-3 | 51-63 | 5 | 11,069 | Jeff Russell | Chris Codiroli | Jeff Russell | Chris Codiroli | | 442 | 503 | -61 |
| 1988-08-14 | @ CLE | 115 | L 0-3 | 51-64 | 5 | 19,628 | Bobby Witt | Greg Swindell | Greg Swindell | Bobby Witt | Doug Jones | 442 | 506 | -64 |
| 1988-08-15 | @ KCA | 116 | L 3-12 | 51-65 | 6 | 33,104 | Paul Kilgus | Charlie Leibrandt | Charlie Leibrandt | Paul Kilgus | | 445 | 518 | -73 |
| 1988-08-16 | @ KCA | 117 | W 5-4 | 52-65 | 6 | 24,729 | Charlie Hough | Mark Gubicza | Charlie Hough | Mark Gubicza | Mitch Williams | 450 | 522 | -72 |
| 1988-08-17 | @ KCA | 118 | L 6-9 | 52-66 | 6 | 25,720 | Jose Guzman | Floyd Bannister | Jeff Montgomery | Jose Guzman | Steve Farr | 456 | 531 | -75 |
| 1988-08-18 | @ MIN | 119 | W 4-2 | 53-66 | 6 | 40,656 | Jeff Russell | Charlie Lea | Jeff Russell | Charlie Lea | | 460 | 533 | -73 |
| 1988-08-19 | @ MIN | 120 | W 5-0 | 54-66 | 5 | 41,675 | Bobby Witt | Freddie Toliver | Bobby Witt | Freddie Toliver | | 465 | 533 | -68 |
| 1988-08-20 | @ MIN | 121 | W 3-2 | 55-66 | 5 | 48,325 | Paul Kilgus | Frank Viola | Paul Kilgus | Frank Viola | Mitch Williams | 468 | 535 | -67 |
| 1988-08-21 | @ MIN | 122 | L 2-12 | 55-67 | 5 | 39,073 | Charlie Hough | Bert Blyleven | Bert Blyleven | Charlie Hough | | 470 | 547 | -77 |
| 1988-08-22 | vs KCA | 123 | W 9-5 | 56-67 | 5 | 16,928 | Jose Guzman | Floyd Bannister | Jose Guzman | Floyd Bannister | Ed Vande Berg | 479 | 552 | -73 |
| 1988-08-23 | vs KCA | 124 | L 7-11 | 56-68 | 5 | 18,051 | Jeff Russell | Luis Aquino | Steve Farr | Dale Mohorcic | | 486 | 563 | -77 |
| 1988-08-24 | vs KCA | 125 | W 7-4 | 57-68 | 5 | 17,384 | Bobby Witt | Bret Saberhagen | Bobby Witt | Jerry Gleaton | | 493 | 567 | -74 |
| 1988-08-26 | vs TOR | 126 | W 5-1 | 58-68 | 5 | 13,642 | Paul Kilgus | Mike Flanagan | Paul Kilgus | Mike Flanagan | Mitch Williams | 498 | 568 | -70 |
| 1988-08-27 | vs TOR | 127 | W 5-3 | 59-68 | 5 | 21,578 | Charlie Hough | Jimmy Key | Charlie Hough | Jimmy Key | Mitch Williams | 503 | 571 | -68 |
| 1988-08-28 | vs TOR | 128 | L 5-6 | 59-69 | 5 | 10,166 | Jose Guzman | Dave Stieb | Tom Henke | Craig McMurtry | | 508 | 577 | -69 |
| 1988-08-29 | vs MIN | 129 | L 2-3 | 59-70 | 5 | 15,095 | Jeff Russell | Freddie Toliver | Freddie Toliver | Jeff Russell | Jeff Reardon | 510 | 580 | -70 |
| 1988-08-30 | vs MIN | 130 | W 8-6 | 60-70 | 5 | 15,245 | Bobby Witt | Roy Smith | Ed Vande Berg | Juan Berenguer | | 518 | 586 | -68 |
| 1988-08-31 | vs MIN | 131 | L 1-10 | 60-71 | 5 | 10,286 | Paul Kilgus | Frank Viola | Frank Viola | Paul Kilgus | | 519 | 596 | -77 |
| 1988-09-01 | @ TOR | 132 | L 1-5 | 60-72 | 5 | 30,294 | Charlie Hough | Jimmy Key | Jimmy Key | Charlie Hough | | 520 | 601 | -81 |
| 1988-09-02 | @ TOR | 133 | L 6-7 | 60-73 | 5 | 30,181 | Scott May | Dave Stieb | Tom Henke | Ed Vande Berg | | 526 | 608 | -82 |
| 1988-09-03 | @ TOR | 134 | L 4-7 | 60-74 | 5 | 33,463 | Jeff Russell | Jim Clancy | Tony Castillo | Jeff Russell | Duane Ward | 530 | 615 | -85 |
| 1988-09-04 | @ TOR | 135 | L 7-9 | 60-75 | 5 | 34,400 | Bobby Witt | Jeff Musselman | John Cerutti | Mitch Williams | | 537 | 624 | -87 |
| 1988-09-05 | vs OAK | 136 | L 4-11 | 60-76 | 5 | 10,934 | Paul Kilgus | Storm Davis | Storm Davis | Paul Kilgus | | 541 | 635 | -94 |
| 1988-09-06 | vs OAK | 137 | W 3-1 | 61-76 | 5 | 9,040 | Charlie Hough | Todd Burns | Charlie Hough | Todd Burns | Cecilio Guante | 544 | 636 | -92 |
| 1988-09-07 | vs OAK | 138 | L 3-6 | 61-77 | 5 | 11,409 | Jose Guzman | Dave Otto | Gene Nelson | Jose Guzman | Dennis Eckersley | 547 | 642 | -95 |
| 1988-09-08 | vs CAL | 139 | L 3-4 | 61-78 | 5 | 7,455 | Jeff Russell | Mike Witt | Mike Witt | Mitch Williams | Bryan Harvey | 550 | 646 | -96 |
| 1988-09-09 | vs CAL | 140 | L 3-5 | 61-79 | 5 | 14,883 | Bobby Witt | Dan Petry | Greg Minton | Bobby Witt | Bryan Harvey | 553 | 651 | -98 |
| 1988-09-10 | vs CAL | 141 | W 3-2 | 62-79 | 5 | 22,972 | Paul Kilgus | Willie Fraser | Ed Vande Berg | Mike Cook | | 556 | 653 | -97 |
| 1988-09-11 | vs CAL | 142 | W 8-3 | 63-79 | 5 | 9,679 | Charlie Hough | Terry Clark | Charlie Hough | Terry Clark | Ed Vande Berg | 564 | 656 | -92 |
| 1988-09-13 | @ OAK | 143 | L 1-2 | 63-80 | 5 | 16,255 | Jose Guzman | Curt Young | Curt Young | Jose Guzman | Dennis Eckersley | 565 | 658 | -93 |
| 1988-09-14 | @ OAK | 144 | W 9-1 | 64-80 | 5 | 14,519 | Kevin Brown | Dave Stewart | Kevin Brown | Dave Stewart | | 574 | 659 | -85 |
| 1988-09-15 | @ OAK | 145 | L 2-6 | 64-81 | 5 | 17,265 | Bobby Witt | Todd Burns | Todd Burns | Bobby Witt | | 576 | 665 | -89 |
| 1988-09-16 | @ CAL | 146 | L 2-7 | 64-82 | 5 | 25,453 | Paul Kilgus | Willie Fraser | Willie Fraser | Paul Kilgus | | 578 | 672 | -94 |
| 1988-09-17 | @ CAL | 147 | W 7-4 | 65-82 | 5 | 23,197 | Charlie Hough | Terry Clark | Charlie Hough | Terry Clark | Dwayne Henry | 585 | 676 | -91 |
| 1988-09-18 | @ CAL | 148 | L 5-6 | 65-83 | 5 | 23,936 | Jeff Russell | Chuck Finley | Bryan Harvey | Mitch Williams | | 590 | 682 | -92 |
| 1988-09-19 | vs CHA | 149 | L 3-7 | 65-84 | 5 | 7,320 | Kevin Brown | Bill Long | Bill Long | Kevin Brown | | 593 | 689 | -96 |
| 1988-09-20 | vs CHA | 150 | W 4-1 | 66-84 | 5 | 8,679 | Bobby Witt | Melido Perez | Bobby Witt | Melido Perez | | 597 | 690 | -93 |
| 1988-09-21 | vs CHA | 151 | L 1-6 | 66-85 | 5 | 8,572 | Jose Guzman | Shawn Hillegas | Shawn Hillegas | Jose Guzman | Bobby Thigpen | 598 | 696 | -98 |
| 1988-09-23 | vs SEA | 152 | W 3-2 | 67-85 | 5 | 11,143 | Charlie Hough | Mike Moore | Charlie Hough | Mike Schooler | | 601 | 698 | -97 |
| 1988-09-24 | vs SEA | 153 | L 0-3 | 67-86 | 5 | 13,219 | Jeff Russell | Mark Langston | Mark Langston | Jeff Russell | | 601 | 701 | -100 |
| 1988-09-25 | vs SEA | 154 | L 5-8 | 67-87 | 6 | 14,349 | Kevin Brown | Mike Campbell | Gene Walter | Craig McMurtry | Mike Schooler | 606 | 709 | -103 |
| 1988-09-26 | @ CHA | 155 | W 5-3 | 68-87 | 5 | 6,970 | Bobby Witt | Melido Perez | Bobby Witt | Bobby Thigpen | | 611 | 712 | -101 |
| 1988-09-27 | @ CHA | 156 | L 2-3 | 68-88 | 6 | 7,093 | Paul Kilgus | Shawn Hillegas | Tom McCarthy | Paul Kilgus | | 613 | 715 | -102 |
| 1988-09-28 | @ CHA | 157 | L 2-3 | 68-89 | 6 | 7,959 | Charlie Hough | Jerry Reuss | Jerry Reuss | Charlie Hough | Bobby Thigpen | 615 | 718 | -103 |
| 1988-09-29 | @ SEA | 158 | L 1-5 | 68-90 | 6 | 6,836 | Jeff Russell | Mark Langston | Mark Langston | Jeff Russell | Mike Schooler | 616 | 723 | -107 |
| 1988-09-30 | @ SEA | 159 | W 11-6 | 69-90 | 6 | 7,870 | Kevin Brown | Mike Moore | Craig McMurtry | Mike Moore | | 627 | 729 | -102 |
| 1988-10-01 | @ SEA | 160 | L 3-4 | 69-91 | 6 | 19,706 | Bobby Witt | Mike Campbell | Bill Swift | Dwayne Henry | | 630 | 733 | -103 |
| 1988-10-02 | @ SEA | 161 | W 7-2 | 70-91 | 6 | 8,696 | Paul Kilgus | Erik Hanson | Paul Kilgus | Erik Hanson | Craig McMurtry | 637 | 735 | -98 |