| 1988-04-04 | @ LAN | 1 | W 5-1 | 1-0 | 2 | 48,484 | Dave Dravecky | Fernando Valenzuela | Dave Dravecky | Fernando Valenzuela | | 5 | 1 | 4 |
| 1988-04-05 | @ LAN | 2 | L 0-5 | 1-1 | 4 | 37,472 | Kelly Downs | Orel Hershiser | Orel Hershiser | Kelly Downs | | 5 | 6 | -1 |
| 1988-04-07 | vs SDN | 3 | W 6-1 | 2-1 | 4 | 54,543 | Mike Krukow | Eric Show | Mike Krukow | Eric Show | | 11 | 7 | 4 |
| 1988-04-08 | vs SDN | 4 | W 5-1 | 3-1 | 3 | 14,916 | Mike LaCoss | Jimmy Jones | Mike LaCoss | Jimmy Jones | Don Robinson | 16 | 8 | 8 |
| 1988-04-09 | vs SDN | 5 | W 3-1 | 4-1 | 2 | 17,930 | Rick Reuschel | Mark Grant | Rick Reuschel | Mark Grant | Scott Garrelts | 19 | 9 | 10 |
| 1988-04-10 | vs SDN | 6 | L 4-6 | 4-2 | 3 | 45,936 | Dave Dravecky | Ed Whitson | Ed Whitson | Dave Dravecky | Lance McCullers | 23 | 15 | 8 |
| 1988-04-11 | vs CIN | 7 | L 0-4 | 4-3 | 4 | 14,435 | Kelly Downs | Mario Soto | Mario Soto | Kelly Downs | | 23 | 19 | 4 |
| 1988-04-12 | vs CIN | 8 | L 3-4 | 4-4 | 4 | 14,045 | Mike Krukow | Danny Jackson | Danny Jackson | Scott Garrelts | John Franco | 26 | 23 | 3 |
| 1988-04-13 | vs CIN | 9 | W 5-4 | 5-4 | 4 | 15,736 | Mike LaCoss | Tom Browning | Don Robinson | Pat Perry | | 31 | 27 | 4 |
| 1988-04-15 | @ SDN | 10 | W 8-3 | 6-4 | 4 | 15,492 | Rick Reuschel | Mark Grant | Rick Reuschel | Mark Grant | Atlee Hammaker | 39 | 30 | 9 |
| 1988-04-16 | @ SDN | 11 | L 1-2 | 6-5 | 4 | 32,095 | Dave Dravecky | Ed Whitson | Mark Davis | Don Robinson | | 40 | 32 | 8 |
| 1988-04-17 | @ SDN | 12 | W 9-4 | 7-5 | 4 | 15,194 | Kelly Downs | Andy Hawkins | Scott Garrelts | Lance McCullers | | 49 | 36 | 13 |
| 1988-04-18 | @ CIN | 13 | W 6-3 | 8-5 | 3 | 15,228 | Mike Krukow | Tom Browning | Craig Lefferts | Pat Perry | Joe Price | 55 | 39 | 16 |
| 1988-04-19 | @ CIN | 14 | L 0-8 | 8-6 | 4 | 15,430 | Mike LaCoss | Dennis Rasmussen | Dennis Rasmussen | Mike LaCoss | | 55 | 47 | 8 |
| 1988-04-20 | @ CIN | 15 | W 5-3 | 9-6 | 3 | 16,690 | Rick Reuschel | Ron Robinson | Rick Reuschel | Ron Robinson | Atlee Hammaker | 60 | 50 | 10 |
| 1988-04-21 | @ CIN | 16 | L 6-7 | 9-7 | 4 | 22,547 | Dave Dravecky | Mario Soto | Pat Perry | Joe Price | | 66 | 57 | 9 |
| 1988-04-23 | vs LAN | 17 | L 3-10 | 9-8 | 4 | 33,271 | Mike Krukow | Orel Hershiser | Orel Hershiser | Mike Krukow | | 69 | 67 | 2 |
| 1988-04-24 | vs LAN | 18 | L 0-4 | 9-9 | 4 | 39,092 | Mike LaCoss | Fernando Valenzuela | Fernando Valenzuela | Mike LaCoss | Jay Howell | 69 | 71 | -2 |
| 1988-04-26 | vs PIT | 19 | L 0-2 | 9-10 | 4 | 11,738 | Rick Reuschel | John Smiley | John Smiley | Rick Reuschel | Jim Gott | 69 | 73 | -4 |
| 1988-04-27 | vs PIT | 20 | W 6-4 | 10-10 | 4 | 10,137 | Dave Dravecky | Doug Drabek | Dave Dravecky | Doug Drabek | Joe Price | 75 | 77 | -2 |
| 1988-04-28 | vs PIT | 21 | L 1-2 | 10-11 | 4 | 10,520 | Kelly Downs | Mike Dunne | Jeff Robinson | Craig Lefferts | Jim Gott | 76 | 79 | -3 |
| 1988-04-29 | vs CHN | 22 | W 4-3 | 11-11 | 4 | 18,662 | Mike Krukow | Rick Sutcliffe | Atlee Hammaker | Rick Sutcliffe | Don Robinson | 80 | 82 | -2 |
| 1988-04-30 | vs CHN | 23 | L 1-2 | 11-12 | 4 | 32,405 | Mike LaCoss | Al Nipper | Les Lancaster | Joe Price | Rich Gossage | 81 | 84 | -3 |
| 1988-05-01 | vs CHN | 24 | W 7-6 | 12-12 | 3 | 30,658 | Rick Reuschel | Greg Maddux | Rick Reuschel | Greg Maddux | Atlee Hammaker | 88 | 90 | -2 |
| 1988-05-02 | vs SLN | 25 | L 1-5 | 12-13 | 4 | 18,398 | Dave Dravecky | Jose DeLeon | Jose DeLeon | Dave Dravecky | Todd Worrell | 89 | 95 | -6 |
| 1988-05-03 | vs SLN | 26 | W 2-0 | 13-13 | 3 | 18,157 | Kelly Downs | Larry McWilliams | Atlee Hammaker | Scott Terry | Craig Lefferts | 91 | 95 | -4 |
| 1988-05-04 | vs SLN | 27 | L 3-5 | 13-14 | 4 | 19,061 | Mike Krukow | Greg Mathews | Greg Mathews | Mike Krukow | Todd Worrell | 94 | 100 | -6 |
| 1988-05-06 | @ CHN | 28 | L 2-3 | 13-15 | 4 | 29,709 | Mike LaCoss | Greg Maddux | Greg Maddux | Mike LaCoss | Rich Gossage | 96 | 103 | -7 |
| 1988-05-07 | @ CHN | 29 | W 2-1 | 14-15 | 4 | 32,596 | Rick Reuschel | Jamie Moyer | Rick Reuschel | Jamie Moyer | Don Robinson | 98 | 104 | -6 |
| 1988-05-08 | @ CHN | 30 | L 7-13 | 14-16 | 4 | 26,355 | Joe Price | Al Nipper | Mike Capel | Scott Garrelts | | 105 | 117 | -12 |
| 1988-05-09 | @ PIT | 31 | W 8-6 | 15-16 | 4 | 6,388 | Mike Krukow | Mike Dunne | Don Robinson | Jeff Robinson | Craig Lefferts | 113 | 123 | -10 |
| 1988-05-10 | @ PIT | 32 | L 2-6 | 15-17 | 4 | 9,275 | Kelly Downs | Vicente Palacios | Vicente Palacios | Kelly Downs | Jim Gott | 115 | 129 | -14 |
| 1988-05-11 | @ SLN | 33 | W 5-4 | 16-17 | 4 | 33,615 | Mike LaCoss | Randy O'Neal | Atlee Hammaker | Bob Forsch | | 120 | 133 | -13 |
| 1988-05-12 | @ SLN | 34 | L 12-13 | 16-18 | 4 | 39,707 | Rick Reuschel | John Tudor | Scott Terry | Craig Lefferts | Todd Worrell | 132 | 146 | -14 |
| 1988-05-13 | vs NYN | 35 | W 3-2 | 17-18 | 3 | 25,275 | Kelly Downs | Bob Ojeda | Kelly Downs | Bob Ojeda | | 135 | 148 | -13 |
| 1988-05-14 | vs NYN | 36 | W 3-2 | 18-18 | 3 | 36,020 | Mike Krukow | Ron Darling | Mike Krukow | Ron Darling | Atlee Hammaker | 138 | 150 | -12 |
| 1988-05-15 | vs NYN | 37 | W 5-1 | 19-18 | 3 | 43,484 | Mike LaCoss | Sid Fernandez | Mike LaCoss | Sid Fernandez | | 143 | 151 | -8 |
| 1988-05-16 | vs PHI | 38 | L 0-3 | 19-19 | 4 | 6,278 | Rick Reuschel | Shane Rawley | Shane Rawley | Rick Reuschel | | 143 | 154 | -11 |
| 1988-05-17 | vs PHI | 39 | L 1-8 | 19-20 | 4 | 9,948 | Kelly Downs | Kevin Gross | Kevin Gross | Kelly Downs | | 144 | 162 | -18 |
| 1988-05-18 | vs PHI | 40 | W 5-1 | 20-20 | 4 | 12,940 | Mike Krukow | Bruce Ruffin | Mike Krukow | Bruce Ruffin | Scott Garrelts | 149 | 163 | -14 |
| 1988-05-20 | vs MON | 41 | W 11-2 | 21-20 | 4 | 15,510 | Mike LaCoss | Bryn Smith | Mike LaCoss | Bryn Smith | | 160 | 165 | -5 |
| 1988-05-21 | vs MON | 42 | L 0-6 | 21-21 | 4 | 31,510 | Rick Reuschel | Floyd Youmans | Floyd Youmans | Rick Reuschel | | 160 | 171 | -11 |
| 1988-05-22 | vs MON | 43 | W 7-2 | 22-21 | 3 | 28,831 | Kelly Downs | Neal Heaton | Kelly Downs | Neal Heaton | | 167 | 173 | -6 |
| 1988-05-24 | @ NYN | 44 | W 4-2 | 23-21 | 3 | 36,816 | Mike Krukow | Bob Ojeda | Mike Krukow | Bob Ojeda | Atlee Hammaker | 171 | 175 | -4 |
| 1988-05-25 | @ NYN | 45 | L 3-6 | 23-22 | 3 | 22,118 | Mike LaCoss | Ron Darling | Ron Darling | Mike LaCoss | Randy Myers | 174 | 181 | -7 |
| 1988-05-26 | @ NYN | 46 | W 5-2 | 24-22 | 3 | 40,586 | Rick Reuschel | Dwight Gooden | Rick Reuschel | Dwight Gooden | Craig Lefferts | 179 | 183 | -4 |
| 1988-05-27 | @ PHI | 47 | L 2-5 | 24-23 | 3 | 24,038 | Kelly Downs | Kevin Gross | Kevin Gross | Kelly Downs | Steve Bedrosian | 181 | 188 | -7 |
| 1988-05-28 | @ PHI | 48 | L 3-4 | 24-24 | 3 | 25,784 | Dave Dravecky | Don Carman | Greg Harris | Randy Bockus | | 184 | 192 | -8 |
| 1988-05-29 | @ PHI | 49 | L 2-4 | 24-25 | 3 | 40,276 | Mike Krukow | Bruce Ruffin | Bruce Ruffin | Mike Krukow | Steve Bedrosian | 186 | 196 | -10 |
| 1988-05-30 | @ MON | 50 | L 2-3 | 24-26 | 3 | 10,762 | Mike LaCoss | Dennis Martinez | Andy McGaffigan | Scott Garrelts | | 188 | 199 | -11 |
| 1988-05-31 | @ MON | 51 | W 9-2 | 25-26 | 3 | 11,902 | Rick Reuschel | Bryn Smith | Rick Reuschel | Bryn Smith | | 197 | 201 | -4 |
| 1988-06-01 | @ MON | 52 | W 2-1 | 26-26 | 3 | 12,074 | Kelly Downs | Floyd Youmans | Kelly Downs | Floyd Youmans | Craig Lefferts | 199 | 202 | -3 |
| 1988-06-03 | vs HOU | 53 | L 4-8 | 26-27 | 3 | 18,840 | Mike Krukow | Mike Scott | Dave Smith | Scott Garrelts | | 203 | 210 | -7 |
| 1988-06-04 | vs HOU | 54 | W 8-2 | 27-27 | 3 | 24,031 | Mike LaCoss | Nolan Ryan | Mike LaCoss | Nolan Ryan | Joe Price | 211 | 212 | -1 |
| 1988-06-05 | vs HOU | 55 | W 9-3 | 28-27 | 3 | 31,144 | Rick Reuschel | Jim Deshaies | Rick Reuschel | Jim Deshaies | Craig Lefferts | 220 | 215 | 5 |
| 1988-06-07 | vs ATL | 56 | W 5-0 | 29-27 | 3 | 7,737 | Kelly Downs | Rick Mahler | Kelly Downs | Rick Mahler | | 225 | 215 | 10 |
| 1988-06-08 | vs ATL | 57 | L 4-5 | 29-28 | 3 | 8,912 | Mike Krukow | Kevin Coffman | Jose Alvarez | Craig Lefferts | Bruce Sutter | 229 | 220 | 9 |
| 1988-06-09 | vs ATL | 58 | W 6-4 | 30-28 | 3 | 10,486 | Mike LaCoss | Pete Smith | Mike LaCoss | Pete Smith | Scott Garrelts | 235 | 224 | 11 |
| 1988-06-10 | vs CIN | 59 | W 9-6 | 31-28 | 3 | 20,990 | Rick Reuschel | Mario Soto | Rick Reuschel | Mario Soto | Don Robinson | 244 | 230 | 14 |
| 1988-06-11 | vs CIN | 60 | L 2-7 | 31-29 | 3 | 31,667 | Atlee Hammaker | Tom Browning | Tom Browning | Craig Lefferts | | 246 | 237 | 9 |
| 1988-06-12 | vs CIN | 61 | L 6-10 | 31-30 | 3 | 40,495 | Kelly Downs | Danny Jackson | Danny Jackson | Kelly Downs | | 252 | 247 | 5 |
| 1988-06-13 | @ SDN | 62 | L 3-7 | 31-31 | 3 | 13,176 | Mike Krukow | Eric Show | Eric Show | Mike Krukow | Mark Davis | 255 | 254 | 1 |
| 1988-06-14 | @ SDN | 63 | L 5-8 | 31-32 | 3 | 13,789 | Mike LaCoss | Jimmy Jones | Greg Booker | Craig Lefferts | Lance McCullers | 260 | 262 | -2 |
| 1988-06-15 | @ SDN | 64 | W 4-2 | 32-32 | 3 | 14,209 | Rick Reuschel | Andy Hawkins | Rick Reuschel | Andy Hawkins | Don Robinson | 264 | 264 | 0 |
| 1988-06-17 | @ CIN | 65 | L 0-6 | 32-33 | 3 | 32,774 | Atlee Hammaker | Danny Jackson | Danny Jackson | Atlee Hammaker | | 264 | 270 | -6 |
| 1988-06-18 | @ CIN | 66 | L 2-3 | 32-34 | 4 | 28,547 | Kelly Downs | Ron Robinson | Ron Robinson | Kelly Downs | John Franco | 266 | 273 | -7 |
| 1988-06-19 | @ CIN | 67 | W 5-3 | 33-34 | 3 | 29,879 | Mike Krukow | Jose Rijo | Mike Krukow | Jose Rijo | Don Robinson | 271 | 276 | -5 |
| 1988-06-20 | vs SDN | 68 | L 1-2 | 33-35 | 4 | 11,440 | Mike LaCoss | Andy Hawkins | Andy Hawkins | Mike LaCoss | Mark Davis | 272 | 278 | -6 |
| 1988-06-21 | vs SDN | 69 | L 3-8 | 33-36 | 4 | 12,363 | Rick Reuschel | Dennis Rasmussen | Dennis Rasmussen | Rick Reuschel | | 275 | 286 | -11 |
| 1988-06-22 | vs SDN | 70 | W 8-7 | 34-36 | 3 | 18,825 | Atlee Hammaker | Ed Whitson | Craig Lefferts | Mark Davis | | 283 | 293 | -10 |
| 1988-06-24 | @ HOU | 71 | W 11-0 | 35-36 | 3 | 35,141 | Kelly Downs | Nolan Ryan | Kelly Downs | Nolan Ryan | | 294 | 293 | 1 |
| 1988-06-25 | @ HOU | 72 | W 4-1 | 36-36 | 3 | 33,218 | Mike Krukow | Danny Darwin | Mike Krukow | Danny Darwin | | 298 | 294 | 4 |
| 1988-06-26 | @ HOU | 73 | L 0-6 | 36-37 | 3 | 25,754 | Mike LaCoss | Jim Deshaies | Jim Deshaies | Mike LaCoss | | 298 | 300 | -2 |
| 1988-06-27 | @ ATL | 74 | W 10-9 | 37-37 | 3 | 5,972 | Rick Reuschel | Rick Mahler | Atlee Hammaker | Rick Mahler | Scott Garrelts | 308 | 309 | -1 |
| 1988-06-28 | @ ATL | 75 | W 13-7 | 38-37 | 3 | 8,229 | Kelly Downs | German Jimenez | Kelly Downs | German Jimenez | Craig Lefferts | 321 | 316 | 5 |
| 1988-06-29 | @ ATL | 76 | W 7-2 | 39-37 | 3 | 6,525 | Don Robinson | Pete Smith | Don Robinson | Pete Smith | Scott Garrelts | 328 | 318 | 10 |
| 1988-07-01 | vs PIT | 77 | L 2-5 | 39-38 | 3 | 39,484 | Rick Reuschel | John Smiley | Jeff Robinson | Atlee Hammaker | | 330 | 323 | 7 |
| 1988-07-02 | vs PIT | 78 | W 2-1 | 40-38 | 2 | 22,355 | Mike LaCoss | Doug Drabek | Mike LaCoss | Dave Rucker | Scott Garrelts | 332 | 324 | 8 |
| 1988-07-03 | vs PIT | 79 | W 4-0 | 41-38 | 2 | 25,463 | Kelly Downs | Mike Dunne | Kelly Downs | Mike Dunne | | 336 | 324 | 12 |
| 1988-07-04 | vs CHN | 80 | L 2-3 | 41-39 | 2 | 22,076 | Don Robinson | Greg Maddux | Greg Maddux | Atlee Hammaker | | 338 | 327 | 11 |
| 1988-07-05 | vs CHN | 81 | W 9-0 | 42-39 | 2 | 13,786 | Terry Mulholland | Calvin Schiraldi | Terry Mulholland | Calvin Schiraldi | | 347 | 327 | 20 |
| 1988-07-06 | vs CHN | 82 | W 2-0 | 43-39 | 2 | 21,884 | Rick Reuschel | Jamie Moyer | Rick Reuschel | Jamie Moyer | Scott Garrelts | 349 | 327 | 22 |
| 1988-07-08 | vs SLN | 83 | W 1-0 | 44-39 | 2 | 24,190 | Mike LaCoss | Joe Magrane | Mike LaCoss | Joe Magrane | | 350 | 327 | 23 |
| 1988-07-09 | vs SLN | 84 | W 21-2 | 45-39 | 2 | 34,666 | Kelly Downs | John Tudor | Kelly Downs | John Tudor | | 371 | 329 | 42 |
| 1988-07-10 | vs SLN | 85 | W 2-1 | 46-39 | 2 | 41,742 | Terry Mulholland | Danny Cox | Terry Mulholland | Danny Cox | | 373 | 330 | 43 |
| 1988-07-14 | @ PIT | 86 | L 2-9 | 46-40 | 2 | 28,325 | Rick Reuschel | John Smiley | Brian Fisher | Rick Reuschel | | 375 | 339 | 36 |
| 1988-07-15 | @ PIT | 87 | L 5-8 | 46-41 | 2 | 28,315 | Kelly Downs | Bob Walk | Bob Kipper | Kelly Downs | Jim Gott | 380 | 347 | 33 |
| 1988-07-16 | @ PIT | 88 | L 1-10 | 46-42 | 2 | 28,997 | Mike LaCoss | Doug Drabek | Doug Drabek | Mike LaCoss | | 381 | 357 | 24 |
| 1988-07-17 | @ PIT | 89 | L 4-5 | 46-43 | 2 | 25,512 | Terry Mulholland | Mike Dunne | Jeff Robinson | Joe Price | Jim Gott | 385 | 362 | 23 |
| 1988-07-18 | @ CHN | 90 | L 3-8 | 46-44 | 2 | 19,289 | Don Robinson | Calvin Schiraldi | Pat Perry | Craig Lefferts | | 388 | 370 | 18 |
| 1988-07-19 | @ CHN | 91 | W 3-1 | 47-44 | 2 | 33,712 | Rick Reuschel | Rick Sutcliffe | Rick Reuschel | Rick Sutcliffe | Scott Garrelts | 391 | 371 | 20 |
| 1988-07-20 | @ CHN | 92 | W 12-2 | 48-44 | 2 | 33,885 | Kelly Downs | Greg Maddux | Kelly Downs | Greg Maddux | | 403 | 373 | 30 |
| 1988-07-21 | @ SLN | 93 | L 4-6 | 48-45 | 3 | 35,983 | Terry Mulholland | Danny Cox | Danny Cox | Joe Price | Todd Worrell | 407 | 379 | 28 |
| 1988-07-22 | @ SLN | 94 | L 2-4 | 48-46 | 3 | 44,472 | Don Robinson | Joe Magrane | Dan Quisenberry | Craig Lefferts | | 409 | 383 | 26 |
| 1988-07-23 | @ SLN | 95 | W 6-5 | 49-46 | 3 | 42,072 | Atlee Hammaker | Bob Forsch | Scott Garrelts | Todd Worrell | | 415 | 388 | 27 |
| 1988-07-24 | @ SLN | 96 | W 5-0 | 50-46 | 3 | 39,183 | Rick Reuschel | Jose DeLeon | Rick Reuschel | Jose DeLeon | | 420 | 388 | 32 |
| 1988-07-25 | vs LAN | 97 | W 3-1 | 51-46 | 3 | 29,947 | Kelly Downs | Fernando Valenzuela | Kelly Downs | Fernando Valenzuela | | 423 | 389 | 34 |
| 1988-07-26 | vs LAN | 98 | L 3-7 | 51-48 | 3 | 0 | Terry Mulholland | Orel Hershiser | Orel Hershiser | Terry Mulholland | Jay Howell | 426 | 396 | 30 |
| 1988-07-26 | vs LAN | 99 | L 5-6 | 51-48 | 3 | 49,209 | Don Robinson | Tim Belcher | Brian Holton | Scott Garrelts | | 431 | 402 | 29 |
| 1988-07-27 | vs LAN | 100 | W 2-1 | 52-48 | 3 | 34,168 | Atlee Hammaker | Tim Leary | Joe Price | Tim Leary | | 433 | 403 | 30 |
| 1988-07-29 | vs ATL | 101 | W 5-3 | 53-48 | 3 | 12,810 | Rick Reuschel | Zane Smith | Rick Reuschel | Zane Smith | | 438 | 406 | 32 |
| 1988-07-30 | vs ATL | 102 | W 2-1 | 54-48 | 3 | 36,289 | Kelly Downs | Rick Mahler | Kelly Downs | Rick Mahler | Craig Lefferts | 440 | 407 | 33 |
| 1988-07-31 | vs ATL | 103 | W 4-2 | 56-48 | 3 | 0 | Terry Mulholland | Pete Smith | Randy Bockus | Jose Alvarez | Scott Garrelts | 444 | 409 | 35 |
| 1988-07-31 | vs ATL | 104 | W 3-2 | 56-48 | 3 | 26,960 | Don Robinson | German Jimenez | Scott Garrelts | Paul Assenmacher | | 447 | 411 | 36 |
| 1988-08-01 | vs HOU | 105 | W 4-1 | 57-48 | 2 | 10,742 | Atlee Hammaker | Nolan Ryan | Atlee Hammaker | Nolan Ryan | | 451 | 412 | 39 |
| 1988-08-02 | vs HOU | 106 | L 10-13 | 57-49 | 3 | 21,457 | Rick Reuschel | Bob Knepper | Danny Darwin | Ron Davis | Dave Smith | 461 | 425 | 36 |
| 1988-08-03 | vs HOU | 107 | L 2-3 | 57-50 | 3 | 28,357 | Joe Price | Mike Scott | Mike Scott | Scott Garrelts | Dave Smith | 463 | 428 | 35 |
| 1988-08-05 | @ ATL | 108 | L 5-8 | 57-51 | 3 | 17,276 | Don Robinson | Rick Mahler | Rick Mahler | Don Robinson | Joe Boever | 468 | 436 | 32 |
| 1988-08-06 | @ ATL | 109 | L 2-7 | 57-52 | 3 | 24,107 | Atlee Hammaker | Pete Smith | Pete Smith | Atlee Hammaker | Jose Alvarez | 470 | 443 | 27 |
| 1988-08-07 | @ ATL | 110 | W 14-4 | 58-52 | 3 | 12,093 | Rick Reuschel | Tom Glavine | Rick Reuschel | Tom Glavine | | 484 | 447 | 37 |
| 1988-08-08 | @ ATL | 111 | W 5-2 | 59-52 | 3 | 7,705 | Joe Price | John Smoltz | Ron Davis | John Smoltz | Scott Garrelts | 489 | 449 | 40 |
| 1988-08-09 | @ HOU | 112 | L 2-3 | 59-53 | 3 | 22,733 | Kelly Downs | Joaquin Andujar | Juan Agosto | Kelly Downs | Dave Smith | 491 | 452 | 39 |
| 1988-08-10 | @ HOU | 113 | W 5-0 | 60-53 | 3 | 25,717 | Don Robinson | Jim Deshaies | Don Robinson | Jim Deshaies | | 496 | 452 | 44 |
| 1988-08-11 | @ HOU | 114 | W 6-0 | 61-53 | 3 | 29,876 | Atlee Hammaker | Nolan Ryan | Atlee Hammaker | Nolan Ryan | | 502 | 452 | 50 |
| 1988-08-12 | @ LAN | 115 | L 3-7 | 61-54 | 3 | 48,744 | Rick Reuschel | Tim Leary | Tim Leary | Rick Reuschel | Alejandro Pena | 505 | 459 | 46 |
| 1988-08-13 | @ LAN | 116 | L 1-2 | 61-55 | 3 | 47,649 | Mike Krukow | Ramon Martinez | Alejandro Pena | Joe Price | | 506 | 461 | 45 |
| 1988-08-14 | @ LAN | 117 | W 15-4 | 62-55 | 3 | 45,502 | Kelly Downs | Orel Hershiser | Kelly Downs | Orel Hershiser | Jeff Brantley | 521 | 465 | 56 |
| 1988-08-15 | @ LAN | 118 | L 0-1 | 62-56 | 3 | 49,306 | Don Robinson | Tim Belcher | Tim Belcher | Don Robinson | Jesse Orosco | 521 | 466 | 55 |
| 1988-08-16 | vs NYN | 119 | L 6-13 | 62-57 | 3 | 29,134 | Atlee Hammaker | Dwight Gooden | Dwight Gooden | Atlee Hammaker | | 527 | 479 | 48 |
| 1988-08-17 | vs NYN | 120 | W 4-0 | 63-57 | 3 | 24,730 | Rick Reuschel | David Cone | Rick Reuschel | David Cone | | 531 | 479 | 52 |
| 1988-08-18 | vs NYN | 121 | W 4-1 | 64-57 | 3 | 32,132 | Mike Krukow | Bob Ojeda | Mike Krukow | Bob Ojeda | Scott Garrelts | 535 | 480 | 55 |
| 1988-08-19 | vs PHI | 122 | W 6-2 | 65-57 | 3 | 14,721 | Kelly Downs | David Palmer | Kelly Downs | Bruce Ruffin | Scott Garrelts | 541 | 482 | 59 |
| 1988-08-20 | vs PHI | 123 | W 4-3 | 66-57 | 3 | 26,818 | Don Robinson | Marvin Freeman | Don Robinson | Marvin Freeman | Scott Garrelts | 545 | 485 | 60 |
| 1988-08-21 | vs PHI | 124 | W 6-3 | 67-57 | 3 | 31,820 | Atlee Hammaker | Don Carman | Atlee Hammaker | Don Carman | Lary Sorensen | 551 | 488 | 63 |
| 1988-08-22 | vs MON | 125 | W 3-2 | 68-57 | 3 | 15,092 | Rick Reuschel | Bryn Smith | Rick Reuschel | Bryn Smith | | 554 | 490 | 64 |
| 1988-08-23 | vs MON | 126 | L 1-2 | 68-58 | 3 | 16,191 | Mike Krukow | Pascual Perez | Andy McGaffigan | Scott Garrelts | Joe Hesketh | 555 | 492 | 63 |
| 1988-08-24 | vs MON | 127 | L 5-7 | 68-59 | 3 | 19,533 | Kelly Downs | Dennis Martinez | Dennis Martinez | Roger Samuels | Joe Hesketh | 560 | 499 | 61 |
| 1988-08-26 | @ NYN | 128 | L 0-3 | 68-60 | 3 | 47,478 | Don Robinson | Sid Fernandez | Sid Fernandez | Don Robinson | Randy Myers | 560 | 502 | 58 |
| 1988-08-27 | @ NYN | 129 | L 1-2 | 68-61 | 3 | 45,115 | Rick Reuschel | Ron Darling | Ron Darling | Rick Reuschel | Randy Myers | 561 | 504 | 57 |
| 1988-08-28 | @ NYN | 130 | W 7-4 | 69-61 | 3 | 46,571 | Mike Krukow | Dwight Gooden | Scott Garrelts | Roger McDowell | | 568 | 508 | 60 |
| 1988-08-29 | @ PHI | 131 | L 0-3 | 69-62 | 3 | 16,854 | Atlee Hammaker | Shane Rawley | Shane Rawley | Atlee Hammaker | Steve Bedrosian | 568 | 511 | 57 |
| 1988-08-30 | @ PHI | 132 | L 5-7 | 69-63 | 3 | 24,730 | Don Robinson | David Palmer | Steve Bedrosian | Craig Lefferts | | 573 | 518 | 55 |
| 1988-08-31 | @ PHI | 133 | W 3-2 | 70-63 | 3 | 23,233 | Rick Reuschel | Marvin Freeman | Scott Garrelts | Bruce Ruffin | | 576 | 520 | 56 |
| 1988-09-02 | @ MON | 134 | L 0-10 | 70-64 | 3 | 12,633 | Atlee Hammaker | Bryn Smith | Bryn Smith | Atlee Hammaker | | 576 | 530 | 46 |
| 1988-09-03 | @ MON | 135 | L 4-6 | 70-65 | 4 | 16,563 | Don Robinson | Pascual Perez | Andy McGaffigan | Roger Samuels | | 580 | 536 | 44 |
| 1988-09-04 | @ MON | 136 | L 2-3 | 70-66 | 4 | 27,395 | Rick Reuschel | Brian Holman | Brian Holman | Rick Reuschel | Tim Burke | 582 | 539 | 43 |
| 1988-09-05 | vs SDN | 137 | L 4-7 | 70-67 | 4 | 13,954 | Trevor Wilson | Eric Show | Eric Show | Trevor Wilson | | 586 | 546 | 40 |
| 1988-09-06 | vs SDN | 138 | L 3-4 | 70-68 | 5 | 5,770 | Atlee Hammaker | Dennis Rasmussen | Dennis Rasmussen | Scott Garrelts | Mark Davis | 589 | 550 | 39 |
| 1988-09-07 | vs ATL | 139 | L 1-4 | 70-69 | 5 | 4,910 | Jeff Brantley | Tom Glavine | Tom Glavine | Jeff Brantley | | 590 | 554 | 36 |
| 1988-09-08 | vs ATL | 140 | W 3-2 | 71-69 | 5 | 5,005 | Don Robinson | John Smoltz | Don Robinson | Charlie Puleo | | 593 | 556 | 37 |
| 1988-09-09 | vs HOU | 141 | L 3-4 | 71-70 | 5 | 13,670 | Rick Reuschel | Bob Knepper | Danny Darwin | Scott Garrelts | | 596 | 560 | 36 |
| 1988-09-10 | vs HOU | 142 | W 3-2 | 72-70 | 5 | 20,054 | Trevor Wilson | Bob Forsch | Craig Lefferts | Juan Agosto | Lary Sorensen | 599 | 562 | 37 |
| 1988-09-11 | vs HOU | 143 | L 1-4 | 72-71 | 5 | 28,304 | Atlee Hammaker | Jim Deshaies | Jim Deshaies | Atlee Hammaker | | 600 | 566 | 34 |
| 1988-09-12 | @ SDN | 144 | W 4-2 | 73-71 | 5 | 22,740 | Dennis Cook | Andy Hawkins | Dennis Cook | Andy Hawkins | Joe Price | 604 | 568 | 36 |
| 1988-09-13 | @ SDN | 145 | W 4-1 | 74-71 | 4 | 9,530 | Rick Reuschel | Ed Whitson | Rick Reuschel | Ed Whitson | Craig Lefferts | 608 | 569 | 39 |
| 1988-09-14 | @ SDN | 146 | W 6-5 | 75-71 | 4 | 10,692 | Don Robinson | Jimmy Jones | Don Robinson | Jimmy Jones | Craig Lefferts | 614 | 574 | 40 |
| 1988-09-16 | @ HOU | 147 | W 5-4 | 76-71 | 4 | 14,344 | Atlee Hammaker | Bob Knepper | Atlee Hammaker | Bob Knepper | Craig Lefferts | 619 | 578 | 41 |
| 1988-09-17 | @ HOU | 148 | W 4-2 | 77-71 | 4 | 19,593 | Rick Reuschel | Jim Deshaies | Rick Reuschel | Jim Deshaies | | 623 | 580 | 43 |
| 1988-09-18 | @ HOU | 149 | W 10-3 | 78-71 | 3 | 13,097 | Don Robinson | Mike Scott | Don Robinson | Mike Scott | | 633 | 583 | 50 |
| 1988-09-19 | @ ATL | 150 | L 3-4 | 78-72 | 4 | 2,351 | Trevor Wilson | Rick Mahler | Jose Alvarez | Joe Price | | 636 | 587 | 49 |
| 1988-09-20 | @ ATL | 151 | W 7-4 | 79-72 | 3 | 3,034 | Dennis Cook | Kevin Blankenship | Roger Samuels | Kevin Blankenship | | 643 | 591 | 52 |
| 1988-09-21 | @ CIN | 152 | L 1-5 | 79-73 | 4 | 15,619 | Rick Reuschel | Tom Browning | Tom Browning | Rick Reuschel | | 644 | 596 | 48 |
| 1988-09-22 | @ CIN | 153 | L 1-3 | 79-74 | 4 | 13,475 | Don Robinson | Jack Armstrong | Jack Armstrong | Don Robinson | John Franco | 645 | 599 | 46 |
| 1988-09-23 | vs LAN | 154 | L 0-3 | 79-75 | 4 | 22,341 | Atlee Hammaker | Orel Hershiser | Orel Hershiser | Atlee Hammaker | | 645 | 602 | 43 |
| 1988-09-24 | vs LAN | 155 | L 3-7 | 79-76 | 4 | 34,214 | Trevor Wilson | John Tudor | Ricky Horton | Trevor Wilson | Jesse Orosco | 648 | 609 | 39 |
| 1988-09-25 | vs LAN | 156 | W 2-0 | 80-76 | 4 | 40,743 | Dennis Cook | Tim Belcher | Dennis Cook | Tim Belcher | | 650 | 609 | 41 |
| 1988-09-26 | vs CIN | 157 | L 2-5 | 80-77 | 4 | 6,797 | Rick Reuschel | Tom Browning | Tom Browning | Rick Reuschel | John Franco | 652 | 614 | 38 |
| 1988-09-27 | vs CIN | 158 | W 6-3 | 81-77 | 4 | 6,979 | Don Robinson | Jack Armstrong | Don Robinson | Jack Armstrong | Craig Lefferts | 658 | 617 | 41 |
| 1988-09-28 | vs CIN | 159 | W 6-1 | 82-77 | 3 | 11,619 | Atlee Hammaker | Danny Jackson | Atlee Hammaker | Danny Jackson | | 664 | 618 | 46 |
| 1988-09-30 | @ LAN | 160 | L 4-6 | 82-78 | 4 | 42,580 | Dennis Cook | John Tudor | Brian Holton | Dennis Cook | Alejandro Pena | 668 | 624 | 44 |
| 1988-10-01 | @ LAN | 161 | L 1-2 | 82-79 | 5 | 33,951 | Rick Reuschel | Tim Belcher | Tim Belcher | Rick Reuschel | Fernando Valenzuela | 669 | 626 | 43 |
| 1988-10-02 | @ LAN | 162 | W 1-0 | 83-79 | 4 | 44,055 | Don Robinson | Tim Leary | Don Robinson | Tim Leary | | 670 | 626 | 44 |