| 1988-04-05 | @ PHI | 1 | W 5-3 | 1-0 | 3 | 46,394 | Mike Dunne | Shane Rawley | Mike Dunne | Shane Rawley | Jeff Robinson | 5 | 3 | 2 |
| 1988-04-06 | @ PHI | 2 | L 5-6 | 1-1 | 5 | 15,532 | Doug Drabek | Kevin Gross | Mike Maddux | Bob Kipper | | 10 | 9 | 1 |
| 1988-04-08 | @ SLN | 3 | W 4-3 | 2-1 | 3 | 51,647 | Brian Fisher | Danny Cox | Brian Fisher | Danny Cox | Jeff Robinson | 14 | 12 | 2 |
| 1988-04-09 | @ SLN | 4 | L 0-3 | 2-2 | 3 | 36,542 | Bob Walk | Greg Mathews | Greg Mathews | Bob Walk | Todd Worrell | 14 | 15 | -1 |
| 1988-04-10 | @ SLN | 5 | W 5-3 | 3-2 | 3 | 31,968 | John Smiley | Joe Magrane | Bob Kipper | Todd Worrell | Jim Gott | 19 | 18 | 1 |
| 1988-04-11 | vs PHI | 6 | W 5-1 | 4-2 | 2 | 54,089 | Doug Drabek | Kevin Gross | Doug Drabek | Kevin Gross | | 24 | 19 | 5 |
| 1988-04-13 | vs PHI | 7 | W 7-0 | 5-2 | 1 | 9,825 | Brian Fisher | Bruce Ruffin | Brian Fisher | Bruce Ruffin | | 31 | 19 | 12 |
| 1988-04-14 | vs PHI | 8 | W 4-2 | 6-2 | 1 | 6,222 | Bob Walk | Don Carman | Bob Walk | Don Carman | Jeff Robinson | 35 | 21 | 14 |
| 1988-04-15 | @ CHN | 9 | L 0-6 | 6-3 | 3 | 35,084 | John Smiley | Rick Sutcliffe | Rick Sutcliffe | John Smiley | | 35 | 27 | 8 |
| 1988-04-16 | @ CHN | 10 | W 4-0 | 7-3 | 2 | 30,564 | Doug Drabek | Greg Maddux | Doug Drabek | Greg Maddux | | 39 | 27 | 12 |
| 1988-04-17 | @ CHN | 11 | W 12-7 | 8-3 | 2 | 29,562 | Vicente Palacios | Calvin Schiraldi | Jeff Robinson | Calvin Schiraldi | | 51 | 34 | 17 |
| 1988-04-19 | vs SLN | 12 | W 3-0 | 9-3 | 1 | 5,048 | Brian Fisher | Danny Cox | Brian Fisher | Danny Cox | | 54 | 34 | 20 |
| 1988-04-20 | vs SLN | 13 | W 8-1 | 10-3 | 1 | 15,522 | Bob Walk | Greg Mathews | Bob Walk | Greg Mathews | | 62 | 35 | 27 |
| 1988-04-21 | vs SLN | 14 | L 3-9 | 10-4 | 1 | 6,833 | John Smiley | Randy O'Neal | Randy O'Neal | John Smiley | | 65 | 44 | 21 |
| 1988-04-22 | vs CHN | 15 | W 8-4 | 11-4 | 1 | 16,250 | Doug Drabek | Calvin Schiraldi | Doug Drabek | Les Lancaster | | 73 | 48 | 25 |
| 1988-04-23 | vs CHN | 16 | W 5-4 | 12-4 | 1 | 20,214 | Brian Fisher | Al Nipper | Jim Gott | Rich Gossage | | 78 | 52 | 26 |
| 1988-04-24 | vs CHN | 17 | W 4-2 | 13-4 | 1 | 19,934 | Bob Walk | Rick Sutcliffe | Bob Walk | Rick Sutcliffe | Jeff Robinson | 82 | 54 | 28 |
| 1988-04-26 | @ SFN | 18 | W 2-0 | 14-4 | 1 | 11,738 | John Smiley | Rick Reuschel | John Smiley | Rick Reuschel | Jim Gott | 84 | 54 | 30 |
| 1988-04-27 | @ SFN | 19 | L 4-6 | 14-5 | 1 | 10,137 | Doug Drabek | Dave Dravecky | Dave Dravecky | Doug Drabek | Joe Price | 88 | 60 | 28 |
| 1988-04-28 | @ SFN | 20 | W 2-1 | 15-5 | 1 | 10,520 | Mike Dunne | Kelly Downs | Jeff Robinson | Craig Lefferts | Jim Gott | 90 | 61 | 29 |
| 1988-04-29 | @ SDN | 21 | L 3-6 | 15-6 | 1 | 16,185 | Brian Fisher | Andy Hawkins | Andy Hawkins | Vicente Palacios | Mark Davis | 93 | 67 | 26 |
| 1988-04-30 | @ SDN | 22 | W 5-1 | 16-6 | 1 | 24,357 | Bob Walk | Mark Grant | Bob Walk | Mark Grant | | 98 | 68 | 30 |
| 1988-05-01 | @ SDN | 23 | W 4-2 | 17-6 | 1 | 21,694 | John Smiley | Eric Show | John Smiley | Eric Show | Jim Gott | 102 | 70 | 32 |
| 1988-05-02 | @ LAN | 24 | L 3-6 | 17-7 | 1 | 26,821 | Doug Drabek | Don Sutton | Jesse Orosco | Doug Drabek | | 105 | 76 | 29 |
| 1988-05-03 | @ LAN | 25 | L 6-14 | 17-8 | 2 | 26,943 | Mike Dunne | Tim Belcher | Tim Belcher | Mike Dunne | | 111 | 90 | 21 |
| 1988-05-04 | @ LAN | 26 | L 5-8 | 17-9 | 2 | 30,423 | Vicente Palacios | Orel Hershiser | Orel Hershiser | Vicente Palacios | | 116 | 98 | 18 |
| 1988-05-06 | vs SDN | 27 | W 4-1 | 18-9 | 2 | 25,045 | Bob Walk | Mark Grant | Barry Jones | Mark Davis | | 120 | 99 | 21 |
| 1988-05-07 | vs SDN | 28 | L 2-3 | 18-10 | 2 | 24,555 | John Smiley | Eric Show | Eric Show | Jim Gott | | 122 | 102 | 20 |
| 1988-05-08 | vs SDN | 29 | W 6-2 | 19-10 | 2 | 20,756 | Doug Drabek | Jimmy Jones | Doug Drabek | Jimmy Jones | | 128 | 104 | 24 |
| 1988-05-09 | vs SFN | 30 | L 6-8 | 19-11 | 2 | 6,388 | Mike Dunne | Mike Krukow | Don Robinson | Jeff Robinson | Craig Lefferts | 134 | 112 | 22 |
| 1988-05-10 | vs SFN | 31 | W 6-2 | 20-11 | 2 | 9,275 | Vicente Palacios | Kelly Downs | Vicente Palacios | Kelly Downs | Jim Gott | 140 | 114 | 26 |
| 1988-05-11 | vs LAN | 32 | W 2-1 | 21-11 | 2 | 26,367 | Bob Walk | Fernando Valenzuela | Scott Medvin | Alejandro Pena | | 142 | 115 | 27 |
| 1988-05-12 | vs LAN | 33 | W 7-4 | 22-11 | 2 | 11,072 | John Smiley | Orel Hershiser | John Smiley | Orel Hershiser | | 149 | 119 | 30 |
| 1988-05-13 | vs CIN | 34 | W 6-5 | 23-11 | 2 | 31,705 | Doug Drabek | Ron Robinson | Jeff Robinson | Rob Murphy | | 155 | 124 | 31 |
| 1988-05-14 | vs CIN | 35 | L 3-5 | 23-12 | 2 | 28,059 | Mike Dunne | Mario Soto | Mario Soto | Mike Dunne | John Franco | 158 | 129 | 29 |
| 1988-05-15 | vs CIN | 36 | L 6-7 | 23-13 | 2 | 33,789 | Brian Fisher | Danny Jackson | John Franco | Barry Jones | | 164 | 136 | 28 |
| 1988-05-16 | @ HOU | 37 | L 2-9 | 23-14 | 2 | 13,570 | Bob Walk | Jim Deshaies | Jim Deshaies | Bob Walk | | 166 | 145 | 21 |
| 1988-05-17 | @ HOU | 38 | L 2-3 | 23-15 | 2 | 15,000 | John Smiley | Mike Scott | Mike Scott | John Smiley | Dave Smith | 168 | 148 | 20 |
| 1988-05-18 | @ HOU | 39 | L 2-4 | 23-16 | 2 | 19,259 | Doug Drabek | Nolan Ryan | Nolan Ryan | Doug Drabek | Dave Smith | 170 | 152 | 18 |
| 1988-05-20 | vs ATL | 40 | W 10-3 | 24-16 | 2 | 18,880 | Mike Dunne | Tom Glavine | Mike Dunne | Tom Glavine | | 180 | 155 | 25 |
| 1988-05-21 | vs ATL | 41 | W 7-3 | 25-16 | 2 | 21,211 | Brian Fisher | Kevin Coffman | Brian Fisher | Kevin Coffman | | 187 | 158 | 29 |
| 1988-05-22 | vs ATL | 42 | L 4-6 | 25-17 | 2 | 32,683 | Bob Walk | Rick Mahler | Rick Mahler | Bob Walk | Bruce Sutter | 191 | 164 | 27 |
| 1988-05-23 | vs HOU | 43 | L 0-3 | 25-18 | 2 | 7,480 | John Smiley | Mike Scott | Mike Scott | John Smiley | | 191 | 167 | 24 |
| 1988-05-24 | vs HOU | 44 | W 5-4 | 26-18 | 2 | 8,200 | Doug Drabek | Nolan Ryan | Jim Gott | Larry Andersen | | 196 | 171 | 25 |
| 1988-05-25 | vs HOU | 45 | W 4-3 | 27-18 | 2 | 8,108 | Mike Dunne | Bob Knepper | Mike Dunne | Joaquin Andujar | Jeff Robinson | 200 | 174 | 26 |
| 1988-05-27 | @ CIN | 46 | L 3-5 | 27-19 | 2 | 29,445 | Brian Fisher | Danny Jackson | Pat Pacillo | Brian Fisher | John Franco | 203 | 179 | 24 |
| 1988-05-28 | @ CIN | 47 | W 5-2 | 28-19 | 2 | 42,232 | Bob Walk | Tom Browning | Bob Walk | Tom Browning | Jeff Robinson | 208 | 181 | 27 |
| 1988-05-29 | @ CIN | 48 | W 4-2 | 29-19 | 2 | 30,660 | John Smiley | Dennis Rasmussen | John Smiley | Dennis Rasmussen | Jim Gott | 212 | 183 | 29 |
| 1988-05-30 | @ ATL | 49 | W 14-2 | 30-19 | 2 | 6,893 | Doug Drabek | Pete Smith | Doug Drabek | Pete Smith | | 226 | 185 | 41 |
| 1988-05-31 | @ ATL | 50 | L 1-11 | 30-20 | 2 | 4,483 | Mike Dunne | Tom Glavine | Tom Glavine | Mike Dunne | | 227 | 196 | 31 |
| 1988-06-01 | @ ATL | 51 | L 2-14 | 30-21 | 2 | 6,059 | Brian Fisher | Rick Mahler | Rick Mahler | Brian Fisher | | 229 | 210 | 19 |
| 1988-06-02 | vs MON | 52 | L 3-7 | 30-22 | 2 | 11,070 | Bob Walk | Neal Heaton | Neal Heaton | Bob Walk | Joe Hesketh | 232 | 217 | 15 |
| 1988-06-03 | vs MON | 53 | W 2-1 | 31-22 | 2 | 19,162 | John Smiley | John Dopson | John Smiley | John Dopson | | 234 | 218 | 16 |
| 1988-06-04 | vs MON | 54 | L 3-7 | 31-23 | 2 | 30,669 | Doug Drabek | Dennis Martinez | Dennis Martinez | Doug Drabek | Bob McClure | 237 | 225 | 12 |
| 1988-06-05 | vs MON | 55 | L 2-3 | 31-24 | 2 | 36,305 | Mike Dunne | Bryn Smith | Bryn Smith | Mike Dunne | Jeff Parrett | 239 | 228 | 11 |
| 1988-06-07 | vs CHN | 56 | L 5-8 | 31-25 | 2 | 9,287 | Brian Fisher | Greg Maddux | Greg Maddux | Brian Fisher | Rich Gossage | 244 | 236 | 8 |
| 1988-06-08 | vs CHN | 57 | W 5-1 | 32-25 | 2 | 22,220 | Bob Walk | Calvin Schiraldi | Bob Walk | Calvin Schiraldi | | 249 | 237 | 12 |
| 1988-06-09 | vs CHN | 58 | W 4-3 | 33-25 | 2 | 8,200 | John Smiley | Jamie Moyer | Jim Gott | Frank DiPino | | 253 | 240 | 13 |
| 1988-06-10 | vs PHI | 59 | L 10-12 | 33-26 | 2 | 20,001 | Doug Drabek | Shane Rawley | Greg Harris | Jeff Robinson | Steve Bedrosian | 263 | 252 | 11 |
| 1988-06-11 | vs PHI | 60 | W 8-2 | 34-26 | 2 | 19,926 | Mike Dunne | David Palmer | Mike Dunne | David Palmer | | 271 | 254 | 17 |
| 1988-06-12 | vs PHI | 61 | L 4-5 | 34-27 | 2 | 36,134 | Brian Fisher | Kevin Gross | Kevin Gross | Brian Fisher | Steve Bedrosian | 275 | 259 | 16 |
| 1988-06-13 | @ CHN | 62 | W 8-0 | 35-27 | 2 | 27,142 | Bob Walk | Calvin Schiraldi | Bob Walk | Calvin Schiraldi | | 283 | 259 | 24 |
| 1988-06-14 | @ CHN | 63 | W 6-3 | 36-27 | 2 | 28,077 | John Smiley | Jamie Moyer | John Smiley | Jamie Moyer | Jeff Robinson | 289 | 262 | 27 |
| 1988-06-15 | @ CHN | 64 | L 4-7 | 36-28 | 2 | 26,126 | Doug Drabek | Jeff Pico | Pat Perry | Jim Gott | Rich Gossage | 293 | 269 | 24 |
| 1988-06-17 | vs SLN | 65 | L 3-7 | 36-29 | 2 | 30,267 | Mike Dunne | Joe Magrane | Joe Magrane | Mike Dunne | | 296 | 276 | 20 |
| 1988-06-18 | vs SLN | 66 | L 3-6 | 36-30 | 2 | 36,682 | Brian Fisher | John Tudor | John Tudor | Brian Fisher | Scott Terry | 299 | 282 | 17 |
| 1988-06-19 | vs SLN | 67 | W 3-2 | 37-30 | 2 | 27,656 | Bob Walk | Larry McWilliams | Bob Walk | Larry McWilliams | Jim Gott | 302 | 284 | 18 |
| 1988-06-20 | @ NYN | 68 | W 8-5 | 38-30 | 2 | 42,413 | John Smiley | Bob Ojeda | John Smiley | Bob Ojeda | Jeff Robinson | 310 | 289 | 21 |
| 1988-06-21 | @ NYN | 69 | L 0-9 | 38-31 | 2 | 45,225 | Doug Drabek | Ron Darling | Ron Darling | Doug Drabek | | 310 | 298 | 12 |
| 1988-06-22 | @ NYN | 70 | L 0-3 | 38-32 | 2 | 41,816 | Mike Dunne | Dwight Gooden | Dwight Gooden | Mike Dunne | Randy Myers | 310 | 301 | 9 |
| 1988-06-23 | @ MON | 71 | W 6-4 | 39-32 | 2 | 14,839 | Brian Fisher | John Dopson | Jeff Robinson | Jeff Parrett | Jim Gott | 316 | 305 | 11 |
| 1988-06-24 | @ MON | 72 | W 5-3 | 40-32 | 2 | 15,781 | Bob Walk | Dennis Martinez | Jim Gott | Bob McClure | Barry Jones | 321 | 308 | 13 |
| 1988-06-25 | @ MON | 73 | W 5-1 | 41-32 | 2 | 17,777 | John Smiley | Brian Holman | John Smiley | Brian Holman | | 326 | 309 | 17 |
| 1988-06-26 | @ MON | 74 | W 3-0 | 42-32 | 2 | 26,593 | Doug Drabek | Pascual Perez | Jeff Robinson | Tim Burke | | 329 | 309 | 20 |
| 1988-06-27 | vs NYN | 75 | W 2-1 | 43-32 | 2 | 41,489 | Mike Dunne | Dwight Gooden | Mike Dunne | Dwight Gooden | Jim Gott | 331 | 310 | 21 |
| 1988-06-28 | vs NYN | 76 | L 2-5 | 43-33 | 2 | 45,011 | Brian Fisher | Sid Fernandez | Sid Fernandez | Brian Fisher | Roger McDowell | 333 | 315 | 18 |
| 1988-06-29 | vs NYN | 77 | L 7-8 | 43-34 | 2 | 41,217 | Bob Walk | David Cone | Roger McDowell | Bob Kipper | | 340 | 323 | 17 |
| 1988-07-01 | @ SFN | 78 | W 5-2 | 44-34 | 2 | 39,484 | John Smiley | Rick Reuschel | Jeff Robinson | Atlee Hammaker | | 345 | 325 | 20 |
| 1988-07-02 | @ SFN | 79 | L 1-2 | 44-35 | 2 | 22,355 | Doug Drabek | Mike LaCoss | Mike LaCoss | Dave Rucker | Scott Garrelts | 346 | 327 | 19 |
| 1988-07-03 | @ SFN | 80 | L 0-4 | 44-36 | 2 | 25,463 | Mike Dunne | Kelly Downs | Kelly Downs | Mike Dunne | | 346 | 331 | 15 |
| 1988-07-04 | @ SDN | 81 | L 3-4 | 44-37 | 3 | 35,406 | Brian Fisher | Eric Show | Mark Davis | Jim Gott | | 349 | 335 | 14 |
| 1988-07-05 | @ SDN | 82 | W 3-2 | 45-37 | 2 | 10,415 | Bob Walk | Jimmy Jones | Bob Walk | Jimmy Jones | Barry Jones | 352 | 337 | 15 |
| 1988-07-07 | @ SDN | 83 | W 2-0 | 46-37 | 2 | 16,076 | John Smiley | Andy Hawkins | John Smiley | Andy Hawkins | Jim Gott | 354 | 337 | 17 |
| 1988-07-08 | @ LAN | 84 | W 4-3 | 47-37 | 2 | 40,690 | Doug Drabek | Tim Leary | Doug Drabek | Tim Leary | Jim Gott | 358 | 340 | 18 |
| 1988-07-09 | @ LAN | 85 | W 8-2 | 48-37 | 2 | 46,662 | Mike Dunne | Shawn Hillegas | Mike Dunne | Shawn Hillegas | | 366 | 342 | 24 |
| 1988-07-10 | @ LAN | 86 | W 7-2 | 49-37 | 2 | 43,014 | Bob Walk | Orel Hershiser | Bob Walk | Orel Hershiser | | 373 | 344 | 29 |
| 1988-07-14 | vs SFN | 87 | W 9-2 | 50-37 | 2 | 28,325 | John Smiley | Rick Reuschel | Brian Fisher | Rick Reuschel | | 382 | 346 | 36 |
| 1988-07-15 | vs SFN | 88 | W 8-5 | 51-37 | 2 | 28,315 | Bob Walk | Kelly Downs | Bob Kipper | Kelly Downs | Jim Gott | 390 | 351 | 39 |
| 1988-07-16 | vs SFN | 89 | W 10-1 | 52-37 | 2 | 28,997 | Doug Drabek | Mike LaCoss | Doug Drabek | Mike LaCoss | | 400 | 352 | 48 |
| 1988-07-17 | vs SFN | 90 | W 5-4 | 53-37 | 2 | 25,512 | Mike Dunne | Terry Mulholland | Jeff Robinson | Joe Price | Jim Gott | 405 | 356 | 49 |
| 1988-07-19 | vs SDN | 91 | L 2-6 | 54-38 | 2 | 0 | John Smiley | Jimmy Jones | Jimmy Jones | John Smiley | | 407 | 362 | 45 |
| 1988-07-19 | vs SDN | 92 | W 9-5 | 54-38 | 2 | 15,847 | Brian Fisher | Andy Hawkins | Brian Fisher | Andy Hawkins | | 416 | 367 | 49 |
| 1988-07-20 | vs SDN | 93 | W 3-2 | 55-38 | 2 | 24,575 | Bob Walk | Dennis Rasmussen | Bob Walk | Dennis Rasmussen | Jim Gott | 419 | 369 | 50 |
| 1988-07-21 | vs LAN | 94 | W 3-2 | 56-38 | 2 | 27,510 | Doug Drabek | Orel Hershiser | Doug Drabek | Orel Hershiser | Jim Gott | 422 | 371 | 51 |
| 1988-07-22 | vs LAN | 95 | L 2-4 | 56-39 | 2 | 44,888 | Mike Dunne | Tim Belcher | Tim Belcher | Mike Dunne | Jay Howell | 424 | 375 | 49 |
| 1988-07-23 | vs LAN | 96 | L 2-6 | 56-40 | 2 | 35,817 | John Smiley | Tim Leary | Tim Leary | John Smiley | | 426 | 381 | 45 |
| 1988-07-24 | vs LAN | 97 | L 1-2 | 56-41 | 2 | 35,677 | Brian Fisher | Shawn Hillegas | Shawn Hillegas | Brian Fisher | Jay Howell | 427 | 383 | 44 |
| 1988-07-25 | @ SLN | 98 | L 1-5 | 56-42 | 2 | 30,763 | Bob Walk | John Tudor | John Tudor | Bob Walk | | 428 | 388 | 40 |
| 1988-07-26 | @ SLN | 99 | W 2-1 | 57-42 | 2 | 32,735 | Doug Drabek | Danny Cox | Doug Drabek | Danny Cox | Jim Gott | 430 | 389 | 41 |
| 1988-07-27 | @ SLN | 100 | W 3-2 | 58-42 | 2 | 31,618 | Mike Dunne | Joe Magrane | Jeff Robinson | Ken Dayley | Jim Gott | 433 | 391 | 42 |
| 1988-07-29 | @ NYN | 101 | L 0-1 | 58-43 | 2 | 49,584 | John Smiley | Bob Ojeda | Bob Ojeda | John Smiley | | 433 | 392 | 41 |
| 1988-07-30 | @ NYN | 102 | L 0-3 | 58-44 | 2 | 50,815 | Brian Fisher | Sid Fernandez | Sid Fernandez | Brian Fisher | Randy Myers | 433 | 395 | 38 |
| 1988-07-31 | @ NYN | 103 | L 1-2 | 58-45 | 2 | 46,917 | Bob Walk | Ron Darling | Ron Darling | Bob Walk | | 434 | 397 | 37 |
| 1988-08-01 | @ NYN | 104 | W 7-2 | 59-45 | 2 | 52,231 | Doug Drabek | Dwight Gooden | Doug Drabek | Dwight Gooden | | 441 | 399 | 42 |
| 1988-08-02 | vs MON | 105 | W 3-2 | 60-45 | 2 | 12,296 | Mike Dunne | Bryn Smith | Jim Gott | Neal Heaton | | 444 | 401 | 43 |
| 1988-08-03 | vs MON | 106 | L 4-6 | 60-46 | 2 | 16,099 | John Smiley | Pascual Perez | Pascual Perez | John Smiley | Tim Burke | 448 | 407 | 41 |
| 1988-08-04 | vs MON | 107 | L 2-3 | 60-47 | 2 | 17,726 | Brian Fisher | John Dopson | John Dopson | Brian Fisher | Tim Burke | 450 | 410 | 40 |
| 1988-08-05 | vs NYN | 108 | L 2-3 | 60-48 | 2 | 39,925 | Bob Walk | Ron Darling | Ron Darling | Bob Walk | Randy Myers | 452 | 413 | 39 |
| 1988-08-06 | vs NYN | 109 | L 3-5 | 60-49 | 2 | 48,272 | Doug Drabek | Dwight Gooden | Bob McClure | Jim Gott | Roger McDowell | 455 | 418 | 37 |
| 1988-08-07 | vs NYN | 110 | L 2-6 | 60-50 | 3 | 44,931 | Mike Dunne | David Cone | David Cone | Bob Kipper | | 457 | 424 | 33 |
| 1988-08-08 | vs NYN | 111 | W 1-0 | 61-50 | 2 | 38,307 | Rick Reed | Bob Ojeda | Rick Reed | Bob Ojeda | Jim Gott | 458 | 424 | 34 |
| 1988-08-09 | @ MON | 112 | W 10-8 | 62-50 | 2 | 37,681 | Brian Fisher | John Dopson | Brian Fisher | John Dopson | Jim Gott | 468 | 432 | 36 |
| 1988-08-10 | @ MON | 113 | L 4-5 | 62-51 | 2 | 29,196 | Bob Walk | Dennis Martinez | Dennis Martinez | Bob Walk | Tim Burke | 472 | 437 | 35 |
| 1988-08-11 | @ MON | 114 | W 6-1 | 63-51 | 2 | 33,599 | Doug Drabek | Brian Holman | Doug Drabek | Brian Holman | Jim Gott | 478 | 438 | 40 |
| 1988-08-12 | @ PHI | 115 | L 1-9 | 63-53 | 2 | 0 | Mike Dunne | Kevin Gross | Kevin Gross | Mike Dunne | | 479 | 447 | 32 |
| 1988-08-12 | @ PHI | 116 | L 4-6 | 63-53 | 2 | 37,673 | John Smiley | David Palmer | Steve Bedrosian | Bob Kipper | | 483 | 453 | 30 |
| 1988-08-13 | @ PHI | 117 | W 10-4 | 64-53 | 2 | 35,432 | Rick Reed | Greg Harris | Jeff Robinson | Greg Harris | | 493 | 457 | 36 |
| 1988-08-14 | @ PHI | 118 | W 9-8 | 65-53 | 2 | 36,468 | Brian Fisher | Marvin Freeman | Jim Gott | Steve Bedrosian | | 502 | 465 | 37 |
| 1988-08-15 | vs ATL | 119 | L 3-4 | 65-54 | 2 | 12,112 | Bob Walk | John Smoltz | Charlie Puleo | Bob Walk | Ed Olwine | 505 | 469 | 36 |
| 1988-08-16 | vs ATL | 120 | W 4-2 | 66-54 | 2 | 13,994 | Doug Drabek | Pete Smith | Doug Drabek | Pete Smith | Jim Gott | 509 | 471 | 38 |
| 1988-08-17 | vs ATL | 121 | W 2-1 | 67-54 | 2 | 33,164 | Dave LaPoint | Tom Glavine | Dave LaPoint | Tom Glavine | Jim Gott | 511 | 472 | 39 |
| 1988-08-19 | vs HOU | 122 | L 1-5 | 67-55 | 2 | 26,352 | Mike Dunne | Danny Darwin | Danny Darwin | Mike Dunne | | 512 | 477 | 35 |
| 1988-08-20 | vs HOU | 123 | W 2-1 | 68-55 | 2 | 23,183 | John Smiley | Nolan Ryan | John Smiley | Nolan Ryan | Jim Gott | 514 | 478 | 36 |
| 1988-08-21 | vs HOU | 124 | L 1-2 | 68-56 | 2 | 38,290 | Bob Walk | Jim Deshaies | Juan Agosto | Bob Kipper | | 515 | 480 | 35 |
| 1988-08-22 | vs CIN | 125 | L 0-2 | 68-57 | 2 | 17,540 | Doug Drabek | Danny Jackson | Danny Jackson | Doug Drabek | | 515 | 482 | 33 |
| 1988-08-23 | vs CIN | 126 | W 2-0 | 69-57 | 2 | 13,406 | Dave LaPoint | Norm Charlton | Dave LaPoint | Norm Charlton | Jim Gott | 517 | 482 | 35 |
| 1988-08-24 | vs CIN | 127 | L 2-6 | 69-58 | 2 | 24,660 | Mike Dunne | Tom Browning | Tom Browning | Mike Dunne | | 519 | 488 | 31 |
| 1988-08-26 | @ HOU | 128 | L 0-2 | 69-59 | 2 | 27,650 | John Smiley | Jim Deshaies | Jim Deshaies | John Smiley | | 519 | 490 | 29 |
| 1988-08-27 | @ HOU | 129 | L 1-3 | 69-60 | 2 | 25,993 | Bob Walk | Mike Scott | Dave Meads | Bob Walk | Juan Agosto | 520 | 493 | 27 |
| 1988-08-28 | @ HOU | 130 | W 4-3 | 70-60 | 2 | 20,368 | Doug Drabek | Danny Darwin | Doug Drabek | Danny Darwin | Jim Gott | 524 | 496 | 28 |
| 1988-08-29 | @ CIN | 131 | W 8-1 | 71-60 | 2 | 19,519 | Dave LaPoint | Keith Brown | Dave LaPoint | Keith Brown | | 532 | 497 | 35 |
| 1988-08-30 | @ CIN | 132 | L 4-6 | 71-61 | 2 | 17,429 | Brian Fisher | Danny Jackson | Danny Jackson | Brian Fisher | John Franco | 536 | 503 | 33 |
| 1988-08-31 | @ CIN | 133 | L 1-4 | 71-62 | 2 | 18,586 | John Smiley | Norm Charlton | Norm Charlton | Jim Gott | John Franco | 537 | 507 | 30 |
| 1988-09-02 | @ ATL | 134 | L 1-2 | 71-63 | 2 | 7,938 | Bob Walk | Tom Glavine | Paul Assenmacher | Jim Gott | | 538 | 509 | 29 |
| 1988-09-05 | vs NYN | 135 | L 5-7 | 71-64 | 2 | 38,876 | Dave LaPoint | David Cone | David Cone | Jeff Robinson | Randy Myers | 543 | 516 | 27 |
| 1988-09-06 | vs NYN | 136 | W 3-2 | 72-64 | 2 | 21,296 | John Smiley | Bob Ojeda | John Smiley | Bob Ojeda | Jim Gott | 546 | 518 | 28 |
| 1988-09-07 | vs MON | 137 | W 5-4 | 73-64 | 2 | 16,494 | Doug Drabek | Bryn Smith | Doug Drabek | Bryn Smith | Jim Gott | 551 | 522 | 29 |
| 1988-09-08 | vs MON | 138 | L 4-5 | 73-65 | 2 | 11,289 | Bob Walk | Pascual Perez | Pascual Perez | Jeff Robinson | Joe Hesketh | 555 | 527 | 28 |
| 1988-09-09 | vs PHI | 139 | W 5-2 | 74-65 | 2 | 15,446 | Mike Dunne | Bob Sebra | Mike Dunne | Bob Sebra | Jim Gott | 560 | 529 | 31 |
| 1988-09-10 | vs PHI | 140 | W 5-1 | 75-65 | 2 | 27,804 | Dave LaPoint | Shane Rawley | Dave LaPoint | Shane Rawley | | 565 | 530 | 35 |
| 1988-09-11 | vs PHI | 141 | L 4-7 | 75-66 | 2 | 18,132 | John Smiley | Marvin Freeman | Marvin Freeman | John Smiley | | 569 | 537 | 32 |
| 1988-09-12 | @ NYN | 142 | L 2-3 | 75-67 | 2 | 39,576 | Doug Drabek | Ron Darling | Randy Myers | Jeff Robinson | | 571 | 540 | 31 |
| 1988-09-13 | @ NYN | 143 | W 1-0 | 76-67 | 2 | 36,633 | Bob Walk | Dwight Gooden | Bob Walk | Dwight Gooden | Jim Gott | 572 | 540 | 32 |
| 1988-09-14 | @ MON | 144 | W 4-1 | 77-67 | 2 | 10,886 | Mike Dunne | Brian Holman | Brian Fisher | Tim Burke | | 576 | 541 | 35 |
| 1988-09-15 | @ MON | 145 | L 4-9 | 77-68 | 2 | 9,494 | Dave LaPoint | Randy Johnson | Randy Johnson | Dave LaPoint | Andy McGaffigan | 580 | 550 | 30 |
| 1988-09-16 | @ PHI | 146 | W 7-5 | 78-68 | 2 | 17,446 | John Smiley | Marvin Freeman | Jeff Robinson | Greg Harris | Jim Gott | 587 | 555 | 32 |
| 1988-09-17 | @ PHI | 147 | W 7-2 | 79-68 | 2 | 14,528 | Doug Drabek | Don Carman | Doug Drabek | Don Carman | Jeff Robinson | 594 | 557 | 37 |
| 1988-09-18 | @ PHI | 148 | L 5-6 | 79-69 | 2 | 21,282 | Bob Walk | Kevin Gross | Steve Bedrosian | Randy Kramer | | 599 | 563 | 36 |
| 1988-09-19 | @ SLN | 149 | W 5-4 | 80-69 | 2 | 19,683 | Mike Dunne | Greg Mathews | Jeff Robinson | Ken Dayley | Jim Gott | 604 | 567 | 37 |
| 1988-09-20 | @ SLN | 150 | W 5-1 | 81-69 | 2 | 27,441 | Dave LaPoint | Scott Terry | Scott Medvin | Scott Terry | Jim Gott | 609 | 568 | 41 |
| 1988-09-21 | @ SLN | 151 | W 5-0 | 82-69 | 2 | 28,350 | John Smiley | Jose DeLeon | John Smiley | Jose DeLeon | | 614 | 568 | 46 |
| 1988-09-23 | vs CHN | 152 | L 3-5 | 82-70 | 2 | 19,552 | Doug Drabek | Greg Maddux | Jamie Moyer | Bob Kipper | | 617 | 573 | 44 |
| 1988-09-24 | vs CHN | 153 | L 1-2 | 82-71 | 2 | 16,161 | Bob Walk | Mike Bielecki | Rich Gossage | Dave Rucker | Frank DiPino | 618 | 575 | 43 |
| 1988-09-25 | vs CHN | 154 | W 7-4 | 83-71 | 2 | 23,095 | Mike Dunne | Rick Sutcliffe | Randy Kramer | Rick Sutcliffe | Jim Gott | 625 | 579 | 46 |
| 1988-09-26 | vs SLN | 155 | L 1-7 | 83-72 | 2 | 9,044 | Dave LaPoint | Jose DeLeon | Jose DeLeon | Dave LaPoint | | 626 | 586 | 40 |
| 1988-09-27 | vs SLN | 156 | W 3-2 | 84-72 | 2 | 8,994 | John Smiley | Ken Hill | John Smiley | Ken Hill | Jim Gott | 629 | 588 | 41 |
| 1988-09-28 | vs SLN | 157 | L 1-2 | 84-73 | 2 | 21,004 | Doug Drabek | Joe Magrane | Joe Magrane | Doug Drabek | | 630 | 590 | 40 |
| 1988-09-30 | @ CHN | 158 | W 10-9 | 85-73 | 2 | 9,805 | Mike Dunne | Rick Sutcliffe | Scott Medvin | Rich Gossage | Brian Fisher | 640 | 599 | 41 |
| 1988-10-01 | @ CHN | 159 | L 7-9 | 85-74 | 2 | 21,433 | Randy Kramer | Kevin Blankenship | Kevin Blankenship | Randy Kramer | Calvin Schiraldi | 647 | 608 | 39 |
| 1988-10-02 | @ CHN | 160 | L 4-8 | 85-75 | 2 | 22,909 | John Smiley | Jamie Moyer | Jamie Moyer | John Smiley | | 651 | 616 | 35 |