| 1988-04-05 | vs PIT | 1 | L 3-5 | 0-1 | 5 | 46,394 | Shane Rawley | Mike Dunne | Mike Dunne | Shane Rawley | Jeff Robinson | 3 | 5 | -2 |
| 1988-04-06 | vs PIT | 2 | W 6-5 | 1-1 | 4 | 15,532 | Kevin Gross | Doug Drabek | Mike Maddux | Bob Kipper | | 9 | 10 | -1 |
| 1988-04-08 | vs NYN | 3 | W 5-1 | 2-1 | 2 | 21,921 | Bruce Ruffin | Sid Fernandez | Bruce Ruffin | Sid Fernandez | | 14 | 11 | 3 |
| 1988-04-09 | vs NYN | 4 | W 9-3 | 3-1 | 2 | 30,994 | Don Carman | Rick Aguilera | Don Carman | Rick Aguilera | | 23 | 14 | 9 |
| 1988-04-10 | vs NYN | 5 | L 3-4 | 3-2 | 2 | 51,781 | Shane Rawley | Dwight Gooden | Dwight Gooden | Shane Rawley | Randy Myers | 26 | 18 | 8 |
| 1988-04-11 | @ PIT | 6 | L 1-5 | 3-3 | 4 | 54,089 | Kevin Gross | Doug Drabek | Doug Drabek | Kevin Gross | | 27 | 23 | 4 |
| 1988-04-13 | @ PIT | 7 | L 0-7 | 3-4 | 4 | 9,825 | Bruce Ruffin | Brian Fisher | Brian Fisher | Bruce Ruffin | | 27 | 30 | -3 |
| 1988-04-14 | @ PIT | 8 | L 2-4 | 3-5 | 4 | 6,222 | Don Carman | Bob Walk | Bob Walk | Don Carman | Jeff Robinson | 29 | 34 | -5 |
| 1988-04-15 | @ MON | 9 | L 4-6 | 3-6 | 5 | 11,292 | Shane Rawley | Floyd Youmans | Andy McGaffigan | Todd Frohwirth | Tim Burke | 33 | 40 | -7 |
| 1988-04-16 | @ MON | 10 | L 1-2 | 3-7 | 5 | 13,664 | Kevin Gross | Bryn Smith | Tim Burke | Kent Tekulve | | 34 | 42 | -8 |
| 1988-04-17 | @ MON | 11 | L 2-5 | 3-8 | 5 | 16,597 | David Palmer | Pascual Perez | Pascual Perez | Bill Dawley | Andy McGaffigan | 36 | 47 | -11 |
| 1988-04-18 | @ NYN | 12 | W 10-7 | 4-8 | 5 | 14,931 | Bruce Ruffin | Rick Aguilera | Bruce Ruffin | Rick Aguilera | | 46 | 54 | -8 |
| 1988-04-19 | @ NYN | 13 | W 10-2 | 5-8 | 5 | 24,555 | Don Carman | Bob Ojeda | Don Carman | Bob Ojeda | | 56 | 56 | 0 |
| 1988-04-20 | @ NYN | 14 | L 2-6 | 5-9 | 5 | 27,714 | Shane Rawley | Dwight Gooden | Dwight Gooden | Shane Rawley | | 58 | 62 | -4 |
| 1988-04-22 | vs MON | 15 | W 2-0 | 6-9 | 5 | 22,113 | Kevin Gross | Pascual Perez | Kevin Gross | Pascual Perez | | 60 | 62 | -2 |
| 1988-04-23 | vs MON | 16 | W 3-3 | 7-9 | 5 | 23,394 | Bruce Ruffin | John Dopson | | | | 63 | 65 | -2 |
| 1988-04-24 | vs MON | 17 | L 1-3 | 7-10 | 5 | 47,917 | Don Carman | Dennis Martinez | Dennis Martinez | Don Carman | Tim Burke | 64 | 68 | -4 |
| 1988-04-26 | @ HOU | 18 | L 1-3 | 7-11 | 5 | 13,152 | Shane Rawley | Mike Scott | Mike Scott | Shane Rawley | Dave Smith | 65 | 71 | -6 |
| 1988-04-27 | @ HOU | 19 | L 2-3 | 7-12 | 5 | 14,462 | Kevin Gross | Nolan Ryan | Dave Smith | Kent Tekulve | | 67 | 74 | -7 |
| 1988-04-30 | vs ATL | 20 | W 7-5 | 8-12 | 5 | 19,138 | Don Carman | Rick Mahler | Don Carman | Rick Mahler | Kent Tekulve | 74 | 79 | -5 |
| 1988-05-01 | vs ATL | 21 | L 5-9 | 8-13 | 6 | 42,491 | Shane Rawley | Tom Glavine | Tom Glavine | Shane Rawley | | 79 | 88 | -9 |
| 1988-05-02 | vs HOU | 22 | W 7-1 | 9-13 | 6 | 18,931 | Kevin Gross | Nolan Ryan | Kevin Gross | Nolan Ryan | | 86 | 89 | -3 |
| 1988-05-03 | vs HOU | 23 | L 0-4 | 9-14 | 6 | 16,443 | Bruce Ruffin | Bob Knepper | Bob Knepper | Bruce Ruffin | | 86 | 93 | -7 |
| 1988-05-04 | @ CIN | 24 | L 1-3 | 9-15 | 6 | 14,302 | David Palmer | Danny Jackson | Danny Jackson | David Palmer | | 87 | 96 | -9 |
| 1988-05-05 | @ CIN | 25 | L 4-10 | 9-16 | 6 | 18,017 | Don Carman | Tom Browning | Jose Rijo | Bill Dawley | | 91 | 106 | -15 |
| 1988-05-06 | @ ATL | 26 | W 7-3 | 10-16 | 6 | 8,377 | Shane Rawley | Tom Glavine | Shane Rawley | Tom Glavine | | 98 | 109 | -11 |
| 1988-05-07 | @ ATL | 27 | L 5-6 | 10-17 | 6 | 15,578 | Kevin Gross | Zane Smith | Paul Assenmacher | Kent Tekulve | | 103 | 115 | -12 |
| 1988-05-08 | @ ATL | 28 | W 5-1 | 11-17 | 6 | 11,232 | Bruce Ruffin | Pete Smith | Bruce Ruffin | Pete Smith | | 108 | 116 | -8 |
| 1988-05-09 | vs CIN | 29 | L 0-2 | 11-18 | 6 | 19,303 | David Palmer | Danny Jackson | Danny Jackson | David Palmer | | 108 | 118 | -10 |
| 1988-05-10 | vs CIN | 30 | L 1-10 | 11-19 | 6 | 22,626 | Don Carman | Tom Browning | Tom Browning | Don Carman | | 109 | 128 | -19 |
| 1988-05-11 | vs CIN | 31 | W 4-3 | 12-19 | 6 | 21,640 | Shane Rawley | Dennis Rasmussen | Kent Tekulve | John Franco | | 113 | 131 | -18 |
| 1988-05-13 | @ LAN | 32 | W 2-1 | 13-19 | 6 | 38,015 | Kevin Gross | Tim Leary | Kevin Gross | Tim Leary | Kent Tekulve | 115 | 132 | -17 |
| 1988-05-14 | @ LAN | 33 | L 2-3 | 13-20 | 6 | 47,379 | Bruce Ruffin | Don Sutton | Don Sutton | Bruce Ruffin | Jay Howell | 117 | 135 | -18 |
| 1988-05-15 | @ LAN | 34 | L 2-9 | 13-21 | 6 | 41,045 | David Palmer | Tim Belcher | Tim Belcher | David Palmer | | 119 | 144 | -25 |
| 1988-05-16 | @ SFN | 35 | W 3-0 | 14-21 | 6 | 6,278 | Shane Rawley | Rick Reuschel | Shane Rawley | Rick Reuschel | | 122 | 144 | -22 |
| 1988-05-17 | @ SFN | 36 | W 8-1 | 15-21 | 6 | 9,948 | Kevin Gross | Kelly Downs | Kevin Gross | Kelly Downs | | 130 | 145 | -15 |
| 1988-05-18 | @ SFN | 37 | L 1-5 | 15-22 | 6 | 12,940 | Bruce Ruffin | Mike Krukow | Mike Krukow | Bruce Ruffin | Scott Garrelts | 131 | 150 | -19 |
| 1988-05-20 | @ SDN | 38 | L 3-4 | 15-23 | 6 | 10,208 | David Palmer | Andy Hawkins | Mark Davis | Kent Tekulve | | 134 | 154 | -20 |
| 1988-05-21 | @ SDN | 39 | W 4-3 | 16-23 | 6 | 15,572 | Shane Rawley | Mark Grant | Shane Rawley | Mark Grant | Steve Bedrosian | 138 | 157 | -19 |
| 1988-05-22 | @ SDN | 40 | L 2-9 | 16-24 | 6 | 40,012 | Kevin Gross | Eric Show | Eric Show | Kevin Gross | | 140 | 166 | -26 |
| 1988-05-24 | vs LAN | 41 | L 1-2 | 16-25 | 6 | 17,759 | Bruce Ruffin | Orel Hershiser | Alejandro Pena | Greg Harris | Jesse Orosco | 141 | 168 | -27 |
| 1988-05-25 | vs LAN | 42 | L 0-4 | 16-26 | 6 | 24,444 | David Palmer | Tim Leary | Tim Leary | David Palmer | | 141 | 172 | -31 |
| 1988-05-26 | vs LAN | 43 | L 8-10 | 16-27 | 6 | 19,361 | Shane Rawley | Don Sutton | Jay Howell | Steve Bedrosian | | 149 | 182 | -33 |
| 1988-05-27 | vs SFN | 44 | W 5-2 | 17-27 | 6 | 24,038 | Kevin Gross | Kelly Downs | Kevin Gross | Kelly Downs | Steve Bedrosian | 154 | 184 | -30 |
| 1988-05-28 | vs SFN | 45 | W 4-3 | 18-27 | 6 | 25,784 | Don Carman | Dave Dravecky | Greg Harris | Randy Bockus | | 158 | 187 | -29 |
| 1988-05-29 | vs SFN | 46 | W 4-2 | 19-27 | 6 | 40,276 | Bruce Ruffin | Mike Krukow | Bruce Ruffin | Mike Krukow | Steve Bedrosian | 162 | 189 | -27 |
| 1988-05-30 | vs SDN | 47 | W 7-3 | 20-27 | 6 | 17,910 | Shane Rawley | Ed Whitson | Shane Rawley | Ed Whitson | | 169 | 192 | -23 |
| 1988-05-31 | vs SDN | 48 | L 0-8 | 20-28 | 6 | 16,733 | David Palmer | Andy Hawkins | Andy Hawkins | David Palmer | | 169 | 200 | -31 |
| 1988-06-01 | vs SDN | 49 | W 9-7 | 21-28 | 6 | 16,270 | Kevin Gross | Mark Grant | Kent Tekulve | Lance McCullers | Greg Harris | 178 | 207 | -29 |
| 1988-06-02 | vs SLN | 50 | L 2-3 | 21-29 | 6 | 20,210 | Don Carman | John Tudor | John Costello | Danny Clay | | 180 | 210 | -30 |
| 1988-06-03 | vs SLN | 51 | L 4-5 | 21-30 | 6 | 26,836 | Bruce Ruffin | Jose DeLeon | Todd Worrell | Greg Harris | | 184 | 215 | -31 |
| 1988-06-04 | vs SLN | 52 | L 1-8 | 21-31 | 6 | 34,081 | Shane Rawley | Cris Carpenter | Cris Carpenter | Shane Rawley | | 185 | 223 | -38 |
| 1988-06-05 | vs SLN | 53 | W 6-3 | 22-31 | 6 | 43,429 | David Palmer | Randy O'Neal | David Palmer | Randy O'Neal | Steve Bedrosian | 191 | 226 | -35 |
| 1988-06-06 | @ MON | 54 | W 5-4 | 23-31 | 6 | 12,127 | Kevin Gross | Floyd Youmans | Kevin Gross | Floyd Youmans | Steve Bedrosian | 196 | 230 | -34 |
| 1988-06-07 | @ MON | 55 | W 10-5 | 24-31 | 6 | 11,556 | Don Carman | Neal Heaton | Greg Harris | Neal Heaton | Kent Tekulve | 206 | 235 | -29 |
| 1988-06-08 | @ MON | 56 | L 4-5 | 24-32 | 6 | 10,214 | Bruce Ruffin | John Dopson | Jeff Parrett | Steve Bedrosian | | 210 | 240 | -30 |
| 1988-06-10 | @ PIT | 57 | W 12-10 | 25-32 | 6 | 20,001 | Shane Rawley | Doug Drabek | Greg Harris | Jeff Robinson | Steve Bedrosian | 222 | 250 | -28 |
| 1988-06-11 | @ PIT | 58 | L 2-8 | 25-33 | 6 | 19,926 | David Palmer | Mike Dunne | Mike Dunne | David Palmer | | 224 | 258 | -34 |
| 1988-06-12 | @ PIT | 59 | W 5-4 | 26-33 | 6 | 36,134 | Kevin Gross | Brian Fisher | Kevin Gross | Brian Fisher | Steve Bedrosian | 229 | 262 | -33 |
| 1988-06-13 | vs MON | 60 | W 5-2 | 27-33 | 6 | 20,544 | Shane Rawley | Neal Heaton | Shane Rawley | Neal Heaton | | 234 | 264 | -30 |
| 1988-06-14 | vs MON | 61 | L 0-9 | 28-34 | 6 | 0 | Bruce Ruffin | Dennis Martinez | Dennis Martinez | Bruce Ruffin | | 234 | 273 | -39 |
| 1988-06-14 | vs MON | 62 | W 4-2 | 28-34 | 6 | 24,082 | Don Carman | John Dopson | Don Carman | John Dopson | Steve Bedrosian | 238 | 275 | -37 |
| 1988-06-15 | vs MON | 63 | W 6-2 | 29-34 | 6 | 23,553 | David Palmer | Floyd Youmans | David Palmer | Floyd Youmans | Steve Bedrosian | 244 | 277 | -33 |
| 1988-06-17 | @ NYN | 64 | W 3-1 | 30-34 | 6 | 46,502 | Kevin Gross | Dwight Gooden | Kevin Gross | Dwight Gooden | Steve Bedrosian | 247 | 278 | -31 |
| 1988-06-18 | @ NYN | 65 | L 2-3 | 30-35 | 6 | 49,307 | Shane Rawley | Sid Fernandez | Terry Leach | Todd Frohwirth | | 249 | 281 | -32 |
| 1988-06-19 | @ NYN | 66 | L 0-6 | 30-36 | 6 | 46,773 | Don Carman | David Cone | David Cone | Don Carman | | 249 | 287 | -38 |
| 1988-06-20 | vs CHN | 67 | L 2-7 | 30-37 | 6 | 26,616 | Bruce Ruffin | Jamie Moyer | Jamie Moyer | Bruce Ruffin | | 251 | 294 | -43 |
| 1988-06-21 | vs CHN | 68 | W 6-1 | 31-37 | 6 | 25,478 | David Palmer | Jeff Pico | David Palmer | Jeff Pico | | 257 | 295 | -38 |
| 1988-06-22 | vs CHN | 69 | W 5-3 | 32-37 | 6 | 27,322 | Mike Maddux | Rick Sutcliffe | Todd Frohwirth | Rick Sutcliffe | Steve Bedrosian | 262 | 298 | -36 |
| 1988-06-23 | @ SLN | 70 | L 0-2 | 32-38 | 6 | 36,176 | Shane Rawley | John Tudor | John Tudor | Shane Rawley | | 262 | 300 | -38 |
| 1988-06-24 | @ SLN | 71 | W 7-6 | 33-38 | 6 | 41,332 | Don Carman | Larry McWilliams | Bruce Ruffin | Todd Worrell | Steve Bedrosian | 269 | 306 | -37 |
| 1988-06-25 | @ SLN | 72 | L 1-4 | 33-39 | 6 | 44,214 | Kevin Gross | Jose DeLeon | Jose DeLeon | Kevin Gross | | 270 | 310 | -40 |
| 1988-06-26 | @ SLN | 73 | W 7-5 | 34-39 | 5 | 38,237 | David Palmer | Bob Forsch | Steve Bedrosian | Larry McWilliams | Bruce Ruffin | 277 | 315 | -38 |
| 1988-06-27 | @ CHN | 74 | L 1-2 | 34-40 | 6 | 27,945 | Shane Rawley | Rick Sutcliffe | Rick Sutcliffe | Shane Rawley | Al Nipper | 278 | 317 | -39 |
| 1988-06-28 | @ CHN | 75 | L 4-6 | 34-41 | 6 | 32,271 | Don Carman | Greg Maddux | Mike Capel | Steve Bedrosian | Les Lancaster | 282 | 323 | -41 |
| 1988-06-29 | @ CHN | 76 | W 4-2 | 35-41 | 6 | 30,812 | Mike Maddux | Calvin Schiraldi | Mike Maddux | Calvin Schiraldi | Steve Bedrosian | 286 | 325 | -39 |
| 1988-07-01 | vs CIN | 77 | L 3-5 | 35-42 | 6 | 56,502 | Shane Rawley | Tom Browning | Tom Browning | Shane Rawley | John Franco | 289 | 330 | -41 |
| 1988-07-02 | vs CIN | 78 | W 5-3 | 36-42 | 6 | 25,122 | David Palmer | Jack Armstrong | David Palmer | Jack Armstrong | Steve Bedrosian | 294 | 333 | -39 |
| 1988-07-03 | vs CIN | 79 | L 2-3 | 36-43 | 6 | 41,899 | Kevin Gross | Danny Jackson | Danny Jackson | Kevin Gross | | 296 | 336 | -40 |
| 1988-07-04 | @ ATL | 80 | L 0-7 | 36-44 | 6 | 23,921 | Don Carman | Pete Smith | Pete Smith | Don Carman | | 296 | 343 | -47 |
| 1988-07-05 | @ ATL | 81 | L 5-10 | 36-45 | 6 | 5,471 | Mike Maddux | Tom Glavine | Jose Alvarez | Bruce Ruffin | | 301 | 353 | -52 |
| 1988-07-06 | @ ATL | 82 | L 2-3 | 36-46 | 6 | 6,537 | Shane Rawley | Zane Smith | Zane Smith | Shane Rawley | Bruce Sutter | 303 | 356 | -53 |
| 1988-07-07 | @ CIN | 83 | L 2-5 | 36-47 | 6 | 31,910 | Kevin Gross | Danny Jackson | Danny Jackson | Kevin Gross | John Franco | 305 | 361 | -56 |
| 1988-07-08 | @ CIN | 84 | W 1-0 | 37-47 | 6 | 30,811 | Don Carman | Jose Rijo | Don Carman | Jose Rijo | Steve Bedrosian | 306 | 361 | -55 |
| 1988-07-09 | @ CIN | 85 | L 3-6 | 37-48 | 6 | 29,473 | Bruce Ruffin | Tom Browning | Rob Dibble | Kent Tekulve | John Franco | 309 | 367 | -58 |
| 1988-07-10 | @ CIN | 86 | L 4-5 | 37-49 | 6 | 29,142 | Shane Rawley | Jack Armstrong | Jack Armstrong | Shane Rawley | John Franco | 313 | 372 | -59 |
| 1988-07-14 | vs HOU | 87 | L 5-7 | 37-50 | 6 | 24,302 | Shane Rawley | Mike Scott | Juan Agosto | Kent Tekulve | Dave Smith | 318 | 379 | -61 |
| 1988-07-15 | vs HOU | 88 | L 2-5 | 37-51 | 6 | 26,545 | Kevin Gross | Jim Deshaies | Jim Deshaies | Kevin Gross | Danny Darwin | 320 | 384 | -64 |
| 1988-07-16 | vs HOU | 89 | W 10-6 | 38-51 | 6 | 32,871 | Don Carman | Nolan Ryan | Bruce Ruffin | Danny Darwin | | 330 | 390 | -60 |
| 1988-07-17 | vs HOU | 90 | W 10-4 | 39-51 | 5 | 28,149 | Mike Maddux | Bob Knepper | Kent Tekulve | Bob Knepper | | 340 | 394 | -54 |
| 1988-07-18 | vs ATL | 91 | L 8-9 | 40-52 | 5 | 0 | Shane Rawley | Rick Mahler | Charlie Puleo | Bruce Ruffin | | 348 | 403 | -55 |
| 1988-07-18 | vs ATL | 92 | W 4-1 | 40-52 | 5 | 22,066 | David Palmer | German Jimenez | David Palmer | German Jimenez | Steve Bedrosian | 352 | 404 | -52 |
| 1988-07-19 | vs ATL | 93 | W 6-4 | 41-52 | 5 | 19,735 | Kevin Gross | Zane Smith | Kevin Gross | Zane Smith | Steve Bedrosian | 358 | 408 | -50 |
| 1988-07-20 | vs ATL | 94 | W 4-3 | 42-52 | 5 | 17,747 | Don Carman | Pete Smith | Don Carman | Pete Smith | Steve Bedrosian | 362 | 411 | -49 |
| 1988-07-21 | @ HOU | 95 | L 0-2 | 42-53 | 6 | 29,654 | Mike Maddux | Nolan Ryan | Nolan Ryan | Mike Maddux | | 362 | 413 | -51 |
| 1988-07-22 | @ HOU | 96 | L 3-5 | 42-54 | 6 | 40,922 | David Palmer | Bob Knepper | Bob Knepper | David Palmer | Danny Darwin | 365 | 418 | -53 |
| 1988-07-23 | @ HOU | 97 | L 6-7 | 42-55 | 6 | 32,931 | Shane Rawley | Joaquin Andujar | Dave Smith | Steve Bedrosian | | 371 | 425 | -54 |
| 1988-07-24 | @ HOU | 98 | W 6-4 | 43-55 | 6 | 25,811 | Kevin Gross | Mike Scott | Kevin Gross | Mike Scott | Steve Bedrosian | 377 | 429 | -52 |
| 1988-07-25 | vs NYN | 99 | W 3-2 | 44-55 | 6 | 42,701 | Don Carman | Ron Darling | Don Carman | Ron Darling | Bruce Ruffin | 380 | 431 | -51 |
| 1988-07-26 | vs NYN | 100 | L 5-7 | 44-56 | 6 | 34,192 | Mike Maddux | David Cone | Terry Leach | Greg Harris | Randy Myers | 385 | 438 | -53 |
| 1988-07-27 | vs NYN | 101 | L 2-10 | 44-57 | 6 | 36,016 | David Palmer | Dwight Gooden | Dwight Gooden | David Palmer | | 387 | 448 | -61 |
| 1988-07-28 | vs CHN | 102 | L 0-7 | 44-58 | 6 | 23,767 | Shane Rawley | Calvin Schiraldi | Calvin Schiraldi | Shane Rawley | | 387 | 455 | -68 |
| 1988-07-29 | vs CHN | 103 | L 3-8 | 44-59 | 6 | 25,118 | Kevin Gross | Rick Sutcliffe | Rick Sutcliffe | Kevin Gross | | 390 | 463 | -73 |
| 1988-07-30 | vs CHN | 104 | W 3-2 | 45-59 | 6 | 24,625 | Don Carman | Al Nipper | Don Carman | Al Nipper | Steve Bedrosian | 393 | 465 | -72 |
| 1988-07-31 | vs CHN | 105 | W 6-3 | 46-59 | 5 | 35,066 | Mike Maddux | Greg Maddux | Mike Maddux | Greg Maddux | Bruce Ruffin | 399 | 468 | -69 |
| 1988-08-02 | @ SLN | 106 | W 2-0 | 47-59 | 5 | 27,744 | David Palmer | Joe Magrane | David Palmer | Joe Magrane | | 401 | 468 | -67 |
| 1988-08-03 | @ SLN | 107 | L 2-4 | 47-60 | 5 | 23,277 | Kevin Gross | Bob Forsch | Bob Forsch | Kevin Gross | Scott Terry | 403 | 472 | -69 |
| 1988-08-04 | @ SLN | 108 | L 2-9 | 47-61 | 6 | 23,955 | Shane Rawley | Jose DeLeon | Jose DeLeon | Shane Rawley | | 405 | 481 | -76 |
| 1988-08-05 | @ CHN | 109 | W 9-3 | 48-61 | 5 | 28,801 | Don Carman | Greg Maddux | Don Carman | Greg Maddux | | 414 | 484 | -70 |
| 1988-08-06 | @ CHN | 110 | L 4-7 | 48-62 | 5 | 32,057 | Mike Maddux | Al Nipper | Al Nipper | Mike Maddux | Rich Gossage | 418 | 491 | -73 |
| 1988-08-07 | @ CHN | 111 | W 7-4 | 49-62 | 5 | 31,350 | David Palmer | Jamie Moyer | David Palmer | Jamie Moyer | Steve Bedrosian | 425 | 495 | -70 |
| 1988-08-09 | vs SLN | 112 | L 3-7 | 49-63 | 5 | 25,533 | Marvin Freeman | Jose DeLeon | Dan Quisenberry | Steve Bedrosian | | 428 | 502 | -74 |
| 1988-08-10 | vs SLN | 113 | L 0-1 | 49-64 | 6 | 24,837 | Don Carman | John Tudor | John Tudor | Don Carman | Todd Worrell | 428 | 503 | -75 |
| 1988-08-11 | vs SLN | 114 | W 1-0 | 50-64 | 5 | 25,607 | Mike Maddux | Scott Terry | Steve Bedrosian | John Costello | | 429 | 503 | -74 |
| 1988-08-12 | vs PIT | 115 | W 9-1 | 52-64 | 5 | 0 | Kevin Gross | Mike Dunne | Kevin Gross | Mike Dunne | | 438 | 504 | -66 |
| 1988-08-12 | vs PIT | 116 | W 6-4 | 52-64 | 5 | 37,673 | David Palmer | John Smiley | Steve Bedrosian | Bob Kipper | | 444 | 508 | -64 |
| 1988-08-13 | vs PIT | 117 | L 4-10 | 52-65 | 5 | 35,432 | Greg Harris | Rick Reed | Jeff Robinson | Greg Harris | | 448 | 518 | -70 |
| 1988-08-14 | vs PIT | 118 | L 8-9 | 52-66 | 5 | 36,468 | Marvin Freeman | Brian Fisher | Jim Gott | Steve Bedrosian | | 456 | 527 | -71 |
| 1988-08-16 | @ LAN | 119 | L 5-7 | 52-67 | 6 | 32,482 | Don Carman | Tim Leary | Tim Leary | Don Carman | Jay Howell | 461 | 534 | -73 |
| 1988-08-17 | @ LAN | 120 | L 2-7 | 52-68 | 6 | 42,701 | Mike Maddux | John Tudor | John Tudor | Mike Maddux | | 463 | 541 | -78 |
| 1988-08-18 | @ LAN | 121 | L 1-2 | 52-69 | 6 | 34,467 | Kevin Gross | Ramon Martinez | Jay Howell | Kevin Gross | Jesse Orosco | 464 | 543 | -79 |
| 1988-08-19 | @ SFN | 122 | L 2-6 | 52-70 | 6 | 14,721 | David Palmer | Kelly Downs | Kelly Downs | Bruce Ruffin | Scott Garrelts | 466 | 549 | -83 |
| 1988-08-20 | @ SFN | 123 | L 3-4 | 52-71 | 6 | 26,818 | Marvin Freeman | Don Robinson | Don Robinson | Marvin Freeman | Scott Garrelts | 469 | 553 | -84 |
| 1988-08-21 | @ SFN | 124 | L 3-6 | 52-72 | 6 | 31,820 | Don Carman | Atlee Hammaker | Atlee Hammaker | Don Carman | Lary Sorensen | 472 | 559 | -87 |
| 1988-08-22 | @ SDN | 125 | W 6-5 | 53-72 | 6 | 20,577 | Mike Maddux | Jimmy Jones | Greg Harris | Jimmy Jones | Steve Bedrosian | 478 | 564 | -86 |
| 1988-08-23 | @ SDN | 126 | L 1-9 | 53-73 | 6 | 10,535 | Kevin Gross | Ed Whitson | Ed Whitson | Kevin Gross | | 479 | 573 | -94 |
| 1988-08-24 | @ SDN | 127 | L 2-5 | 53-74 | 6 | 14,632 | David Palmer | Eric Show | Eric Show | David Palmer | | 481 | 578 | -97 |
| 1988-08-26 | vs LAN | 128 | L 2-7 | 53-75 | 6 | 27,533 | Marvin Freeman | Tim Belcher | Tim Belcher | Marvin Freeman | | 483 | 585 | -102 |
| 1988-08-27 | vs LAN | 129 | L 2-4 | 53-76 | 6 | 27,324 | Don Carman | Tim Leary | Tim Leary | Don Carman | Jay Howell | 485 | 589 | -104 |
| 1988-08-28 | vs LAN | 130 | L 0-5 | 53-77 | 6 | 28,570 | Kevin Gross | John Tudor | John Tudor | Kevin Gross | | 485 | 594 | -109 |
| 1988-08-29 | vs SFN | 131 | W 3-0 | 54-77 | 6 | 16,854 | Shane Rawley | Atlee Hammaker | Shane Rawley | Atlee Hammaker | Steve Bedrosian | 488 | 594 | -106 |
| 1988-08-30 | vs SFN | 132 | W 7-5 | 55-77 | 6 | 24,730 | David Palmer | Don Robinson | Steve Bedrosian | Craig Lefferts | | 495 | 599 | -104 |
| 1988-08-31 | vs SFN | 133 | L 2-3 | 55-78 | 6 | 23,233 | Marvin Freeman | Rick Reuschel | Scott Garrelts | Bruce Ruffin | | 497 | 602 | -105 |
| 1988-09-02 | vs SDN | 134 | L 4-7 | 55-79 | 6 | 15,384 | Don Carman | Jimmy Jones | Jimmy Jones | Don Carman | Mark Davis | 501 | 609 | -108 |
| 1988-09-03 | vs SDN | 135 | L 2-5 | 55-80 | 6 | 16,315 | Kevin Gross | Ed Whitson | Ed Whitson | Kevin Gross | | 503 | 614 | -111 |
| 1988-09-05 | @ CHN | 136 | L 3-14 | 56-81 | 6 | 0 | Bob Sebra | Rick Sutcliffe | Rick Sutcliffe | Bob Sebra | | 506 | 628 | -122 |
| 1988-09-05 | @ CHN | 137 | W 4-3 | 56-81 | 6 | 27,084 | Shane Rawley | Mike Harkey | Shane Rawley | Scott Sanderson | Steve Bedrosian | 510 | 631 | -121 |
| 1988-09-06 | @ CHN | 138 | W 3-2 | 57-81 | 6 | 23,189 | Marvin Freeman | Jamie Moyer | Marvin Freeman | Jamie Moyer | Steve Bedrosian | 513 | 633 | -120 |
| 1988-09-07 | @ SLN | 139 | L 0-5 | 57-82 | 6 | 23,535 | Don Carman | Joe Magrane | Joe Magrane | Don Carman | | 513 | 638 | -125 |
| 1988-09-08 | @ SLN | 140 | L 0-1 | 57-83 | 6 | 19,211 | Kevin Gross | Larry McWilliams | Larry McWilliams | Kevin Gross | Todd Worrell | 513 | 639 | -126 |
| 1988-09-09 | @ PIT | 141 | L 2-5 | 57-84 | 6 | 15,446 | Bob Sebra | Mike Dunne | Mike Dunne | Bob Sebra | Jim Gott | 515 | 644 | -129 |
| 1988-09-10 | @ PIT | 142 | L 1-5 | 57-85 | 6 | 27,804 | Shane Rawley | Dave LaPoint | Dave LaPoint | Shane Rawley | | 516 | 649 | -133 |
| 1988-09-11 | @ PIT | 143 | W 7-4 | 58-85 | 6 | 18,132 | Marvin Freeman | John Smiley | Marvin Freeman | John Smiley | | 523 | 653 | -130 |
| 1988-09-12 | vs CHN | 144 | W 5-1 | 59-85 | 6 | 13,433 | Don Carman | Jamie Moyer | Don Carman | Jamie Moyer | Kent Tekulve | 528 | 654 | -126 |
| 1988-09-13 | vs CHN | 145 | L 2-9 | 59-86 | 6 | 13,301 | Kevin Gross | Greg Maddux | Greg Maddux | Kevin Gross | | 530 | 663 | -133 |
| 1988-09-14 | vs SLN | 146 | W 9-2 | 60-86 | 6 | 13,829 | Bob Sebra | Greg Mathews | Bob Sebra | Greg Mathews | | 539 | 665 | -126 |
| 1988-09-15 | vs SLN | 147 | L 1-3 | 60-87 | 6 | 10,434 | Shane Rawley | Scott Terry | Scott Terry | Shane Rawley | Todd Worrell | 540 | 668 | -128 |
| 1988-09-16 | vs PIT | 148 | L 5-7 | 60-88 | 6 | 17,446 | Marvin Freeman | John Smiley | Jeff Robinson | Greg Harris | Jim Gott | 545 | 675 | -130 |
| 1988-09-17 | vs PIT | 149 | L 2-7 | 60-89 | 6 | 14,528 | Don Carman | Doug Drabek | Doug Drabek | Don Carman | Jeff Robinson | 547 | 682 | -135 |
| 1988-09-18 | vs PIT | 150 | W 6-5 | 61-89 | 6 | 21,282 | Kevin Gross | Bob Walk | Steve Bedrosian | Randy Kramer | | 553 | 687 | -134 |
| 1988-09-20 | @ NYN | 151 | L 4-6 | 61-90 | 6 | 30,337 | Shane Rawley | David Cone | David Cone | Shane Rawley | | 557 | 693 | -136 |
| 1988-09-21 | @ NYN | 152 | L 3-4 | 61-91 | 6 | 35,450 | Marvin Freeman | Sid Fernandez | Sid Fernandez | Marvin Freeman | Randy Myers | 560 | 697 | -137 |
| 1988-09-22 | @ NYN | 153 | L 1-3 | 61-92 | 6 | 45,274 | Don Carman | Ron Darling | Ron Darling | Don Carman | | 561 | 700 | -139 |
| 1988-09-23 | vs MON | 154 | L 2-3 | 61-93 | 6 | 13,386 | Kevin Gross | Bryn Smith | Jeff Parrett | Kent Tekulve | Tim Burke | 563 | 703 | -140 |
| 1988-09-24 | vs MON | 155 | L 0-1 | 61-94 | 6 | 14,088 | Alex Madrid | Pascual Perez | Pascual Perez | Alex Madrid | | 563 | 704 | -141 |
| 1988-09-25 | vs MON | 156 | W 8-5 | 62-94 | 6 | 20,188 | Shane Rawley | Dennis Martinez | Shane Rawley | Dennis Martinez | Steve Bedrosian | 571 | 709 | -138 |
| 1988-09-26 | vs NYN | 157 | L 4-10 | 62-95 | 6 | 20,694 | Marvin Freeman | Sid Fernandez | Sid Fernandez | Greg Harris | | 575 | 719 | -144 |
| 1988-09-27 | vs NYN | 158 | W 5-4 | 63-95 | 6 | 19,259 | Don Carman | Ron Darling | Steve Bedrosian | Roger McDowell | | 580 | 723 | -143 |
| 1988-09-28 | vs NYN | 159 | W 9-3 | 64-95 | 6 | 20,914 | Kevin Gross | Dwight Gooden | Kevin Gross | Dwight Gooden | | 589 | 726 | -137 |
| 1988-09-30 | @ MON | 160 | W 2-1 | 65-95 | 6 | 7,362 | Alex Madrid | Pascual Perez | Alex Madrid | Pascual Perez | Steve Bedrosian | 591 | 727 | -136 |
| 1988-10-01 | @ MON | 161 | W 5-4 | 66-95 | 6 | 9,105 | Marvin Freeman | Randy Johnson | Mike Maddux | Jeff Parrett | Steve Bedrosian | 596 | 731 | -135 |
| 1988-10-02 | @ MON | 162 | L 1-3 | 66-96 | 6 | 13,498 | Don Carman | Brian Holman | Brian Holman | Don Carman | Joe Hesketh | 597 | 734 | -137 |