| 1988-04-04 | @ MON | 1 | W 10-6 | 1-0 | 1 | 55,413 | Dwight Gooden | Dennis Martinez | Dwight Gooden | Dennis Martinez | Randy Myers | 10 | 6 | 4 |
| 1988-04-06 | @ MON | 2 | L 1-5 | 1-1 | 3 | 11,112 | Ron Darling | Pascual Perez | Pascual Perez | Ron Darling | | 11 | 11 | 0 |
| 1988-04-07 | @ MON | 3 | W 8-5 | 2-1 | 2 | 10,193 | Bob Ojeda | Neal Heaton | Bob Ojeda | Neal Heaton | | 19 | 16 | 3 |
| 1988-04-08 | @ PHI | 4 | L 1-5 | 2-2 | 4 | 21,921 | Sid Fernandez | Bruce Ruffin | Bruce Ruffin | Sid Fernandez | | 20 | 21 | -1 |
| 1988-04-09 | @ PHI | 5 | L 3-9 | 2-3 | 5 | 30,994 | Rick Aguilera | Don Carman | Don Carman | Rick Aguilera | | 23 | 30 | -7 |
| 1988-04-10 | @ PHI | 6 | W 4-3 | 3-3 | 4 | 51,781 | Dwight Gooden | Shane Rawley | Dwight Gooden | Shane Rawley | Randy Myers | 27 | 33 | -6 |
| 1988-04-12 | vs MON | 7 | W 3-0 | 4-3 | 3 | 48,719 | Ron Darling | Pascual Perez | Ron Darling | Pascual Perez | | 30 | 33 | -3 |
| 1988-04-14 | vs MON | 8 | W 1-0 | 5-3 | 3 | 19,612 | Bob Ojeda | Dennis Martinez | Bob Ojeda | Dennis Martinez | | 31 | 33 | -2 |
| 1988-04-15 | vs SLN | 9 | W 3-0 | 6-3 | 2 | 33,094 | Dwight Gooden | Greg Mathews | Dwight Gooden | Greg Mathews | | 34 | 33 | 1 |
| 1988-04-16 | vs SLN | 10 | W 6-4 | 7-3 | 1 | 40,582 | Sid Fernandez | Joe Magrane | David Cone | Todd Worrell | Randy Myers | 40 | 37 | 3 |
| 1988-04-17 | vs SLN | 11 | W 3-2 | 8-3 | 1 | 48,760 | Ron Darling | Jose DeLeon | Roger McDowell | Steve Peters | | 43 | 39 | 4 |
| 1988-04-18 | vs PHI | 12 | L 7-10 | 8-4 | 2 | 14,931 | Rick Aguilera | Bruce Ruffin | Bruce Ruffin | Rick Aguilera | | 50 | 49 | 1 |
| 1988-04-19 | vs PHI | 13 | L 2-10 | 8-5 | 2 | 24,555 | Bob Ojeda | Don Carman | Don Carman | Bob Ojeda | | 52 | 59 | -7 |
| 1988-04-20 | vs PHI | 14 | W 6-2 | 9-5 | 2 | 27,714 | Dwight Gooden | Shane Rawley | Dwight Gooden | Shane Rawley | | 58 | 61 | -3 |
| 1988-04-22 | @ SLN | 15 | W 4-0 | 10-5 | 2 | 47,207 | Ron Darling | Jose DeLeon | Ron Darling | Jose DeLeon | | 62 | 61 | 1 |
| 1988-04-23 | @ SLN | 16 | W 12-9 | 11-5 | 2 | 45,110 | Sid Fernandez | Bob Forsch | Roger McDowell | Steve Peters | Randy Myers | 74 | 70 | 4 |
| 1988-04-24 | @ SLN | 17 | L 4-5 | 11-6 | 2 | 41,617 | Bob Ojeda | Danny Cox | Danny Cox | Jeff Innis | Todd Worrell | 78 | 75 | 3 |
| 1988-04-26 | @ ATL | 18 | W 13-4 | 12-6 | 2 | 10,405 | Dwight Gooden | Tom Glavine | Dwight Gooden | Jim Acker | | 91 | 79 | 12 |
| 1988-04-27 | @ ATL | 19 | W 5-2 | 13-6 | 2 | 6,928 | Ron Darling | Zane Smith | David Cone | Paul Assenmacher | Roger McDowell | 96 | 81 | 15 |
| 1988-04-29 | @ CIN | 20 | W 5-4 | 14-6 | 2 | 29,833 | Sid Fernandez | Danny Jackson | Roger McDowell | Rob Murphy | | 101 | 85 | 16 |
| 1988-04-30 | @ CIN | 21 | W 6-5 | 15-6 | 2 | 33,463 | Bob Ojeda | Tom Browning | Randy Myers | John Franco | | 107 | 90 | 17 |
| 1988-05-01 | @ CIN | 22 | W 11-0 | 16-6 | 2 | 31,525 | Dwight Gooden | Dennis Rasmussen | Dwight Gooden | Dennis Rasmussen | | 118 | 90 | 28 |
| 1988-05-02 | vs ATL | 23 | L 1-3 | 16-7 | 2 | 20,869 | Ron Darling | Zane Smith | Zane Smith | Ron Darling | | 119 | 93 | 26 |
| 1988-05-03 | vs ATL | 24 | W 8-0 | 17-7 | 1 | 24,532 | David Cone | Pete Smith | David Cone | Pete Smith | | 127 | 93 | 34 |
| 1988-05-04 | vs HOU | 25 | W 8-0 | 18-7 | 1 | 29,936 | Sid Fernandez | Danny Darwin | Sid Fernandez | Danny Darwin | Terry Leach | 135 | 93 | 42 |
| 1988-05-06 | vs CIN | 26 | W 4-3 | 19-7 | 1 | 22,857 | Dwight Gooden | Dennis Rasmussen | Randy Myers | John Franco | | 139 | 96 | 43 |
| 1988-05-07 | vs CIN | 27 | W 2-1 | 20-7 | 1 | 49,232 | Bob Ojeda | Ron Robinson | Bob Ojeda | Ron Robinson | Roger McDowell | 141 | 97 | 44 |
| 1988-05-08 | vs CIN | 28 | W 5-1 | 21-7 | 1 | 47,875 | Ron Darling | Mario Soto | Ron Darling | Mario Soto | | 146 | 98 | 48 |
| 1988-05-09 | @ HOU | 29 | L 2-6 | 21-8 | 1 | 18,388 | Sid Fernandez | Danny Darwin | Danny Darwin | Sid Fernandez | | 148 | 104 | 44 |
| 1988-05-10 | @ HOU | 30 | W 5-2 | 22-8 | 1 | 19,064 | David Cone | Jim Deshaies | David Cone | Ernie Camacho | Roger McDowell | 153 | 106 | 47 |
| 1988-05-11 | @ HOU | 31 | W 9-8 | 23-8 | 1 | 29,565 | Dwight Gooden | Mike Scott | Terry Leach | Dave Smith | | 162 | 114 | 48 |
| 1988-05-13 | @ SFN | 32 | L 2-3 | 23-9 | 1 | 25,275 | Bob Ojeda | Kelly Downs | Kelly Downs | Bob Ojeda | | 164 | 117 | 47 |
| 1988-05-14 | @ SFN | 33 | L 2-3 | 23-10 | 1 | 36,020 | Ron Darling | Mike Krukow | Mike Krukow | Ron Darling | Atlee Hammaker | 166 | 120 | 46 |
| 1988-05-15 | @ SFN | 34 | L 1-5 | 23-11 | 1 | 43,484 | Sid Fernandez | Mike LaCoss | Mike LaCoss | Sid Fernandez | | 167 | 125 | 42 |
| 1988-05-16 | @ SDN | 35 | W 7-4 | 24-11 | 1 | 15,445 | Dwight Gooden | Mark Grant | Dwight Gooden | Greg Booker | Roger McDowell | 174 | 129 | 45 |
| 1988-05-17 | @ SDN | 36 | W 1-0 | 25-11 | 1 | 12,035 | David Cone | Eric Show | David Cone | Mark Davis | Randy Myers | 175 | 129 | 46 |
| 1988-05-18 | @ SDN | 37 | W 5-2 | 26-11 | 1 | 17,163 | Bob Ojeda | Jimmy Jones | Bob Ojeda | Jimmy Jones | | 180 | 131 | 49 |
| 1988-05-19 | @ SDN | 38 | W 9-4 | 27-11 | 1 | 19,844 | Ron Darling | Ed Whitson | Ron Darling | Ed Whitson | | 189 | 135 | 54 |
| 1988-05-20 | @ LAN | 39 | W 5-2 | 28-11 | 1 | 44,867 | Sid Fernandez | Don Sutton | Sid Fernandez | Don Sutton | Randy Myers | 194 | 137 | 57 |
| 1988-05-21 | @ LAN | 40 | W 4-0 | 29-11 | 1 | 47,017 | Dwight Gooden | Tim Belcher | Dwight Gooden | Tim Belcher | | 198 | 137 | 61 |
| 1988-05-22 | @ LAN | 41 | W 5-2 | 30-11 | 1 | 44,826 | David Cone | Fernando Valenzuela | David Cone | Fernando Valenzuela | Roger McDowell | 203 | 139 | 64 |
| 1988-05-24 | vs SFN | 42 | L 2-4 | 30-12 | 1 | 36,816 | Bob Ojeda | Mike Krukow | Mike Krukow | Bob Ojeda | Atlee Hammaker | 205 | 143 | 62 |
| 1988-05-25 | vs SFN | 43 | W 6-3 | 31-12 | 1 | 22,118 | Ron Darling | Mike LaCoss | Ron Darling | Mike LaCoss | Randy Myers | 211 | 146 | 65 |
| 1988-05-26 | vs SFN | 44 | L 2-5 | 31-13 | 1 | 40,586 | Dwight Gooden | Rick Reuschel | Rick Reuschel | Dwight Gooden | Craig Lefferts | 213 | 151 | 62 |
| 1988-05-27 | vs SDN | 45 | L 0-2 | 31-14 | 1 | 36,074 | Sid Fernandez | Mark Grant | Mark Grant | Sid Fernandez | Mark Davis | 213 | 153 | 60 |
| 1988-05-28 | vs SDN | 46 | W 5-1 | 32-14 | 1 | 40,940 | David Cone | Eric Show | David Cone | Eric Show | Roger McDowell | 218 | 154 | 64 |
| 1988-05-29 | vs SDN | 47 | L 3-6 | 32-15 | 1 | 46,189 | Bob Ojeda | Jimmy Jones | Jimmy Jones | Bob Ojeda | Mark Davis | 221 | 160 | 61 |
| 1988-05-30 | vs LAN | 48 | W 3-2 | 33-15 | 1 | 42,096 | Ron Darling | Tim Leary | Ron Darling | Tim Leary | Randy Myers | 224 | 162 | 62 |
| 1988-05-31 | vs LAN | 49 | W 5-4 | 34-15 | 1 | 35,564 | Dwight Gooden | Don Sutton | Randy Myers | Alejandro Pena | | 229 | 166 | 63 |
| 1988-06-01 | vs LAN | 50 | L 3-4 | 34-16 | 1 | 29,659 | Sid Fernandez | Tim Belcher | Brian Holton | Sid Fernandez | Jay Howell | 232 | 170 | 62 |
| 1988-06-02 | vs CHN | 51 | W 2-1 | 35-16 | 1 | 29,578 | David Cone | Calvin Schiraldi | Randy Myers | Frank DiPino | | 234 | 171 | 63 |
| 1988-06-03 | vs CHN | 52 | L 0-5 | 35-17 | 1 | 40,516 | Bob Ojeda | Jamie Moyer | Jamie Moyer | Bob Ojeda | | 234 | 176 | 58 |
| 1988-06-04 | vs CHN | 53 | W 6-5 | 36-17 | 1 | 48,052 | Ron Darling | Les Lancaster | Jeff Innis | Mike Capel | | 240 | 181 | 59 |
| 1988-06-05 | vs CHN | 54 | W 11-3 | 37-17 | 1 | 47,243 | Dwight Gooden | Jeff Pico | Dwight Gooden | Jeff Pico | | 251 | 184 | 67 |
| 1988-06-06 | @ SLN | 55 | W 6-2 | 38-17 | 1 | 44,199 | Sid Fernandez | Larry McWilliams | Sid Fernandez | Larry McWilliams | Randy Myers | 257 | 186 | 71 |
| 1988-06-07 | @ SLN | 56 | L 1-4 | 38-18 | 1 | 41,278 | David Cone | John Tudor | John Tudor | David Cone | Ken Dayley | 258 | 190 | 68 |
| 1988-06-08 | @ SLN | 57 | L 2-5 | 38-19 | 1 | 38,451 | Bob Ojeda | Jose DeLeon | Steve Peters | Roger McDowell | Todd Worrell | 260 | 195 | 65 |
| 1988-06-10 | @ MON | 58 | L 2-5 | 38-20 | 1 | 28,697 | Ron Darling | Dennis Martinez | Dennis Martinez | Ron Darling | Jeff Parrett | 262 | 200 | 62 |
| 1988-06-11 | @ MON | 59 | L 4-6 | 38-21 | 1 | 31,576 | Dwight Gooden | Floyd Youmans | Floyd Youmans | Dwight Gooden | Andy McGaffigan | 266 | 206 | 60 |
| 1988-06-12 | @ MON | 60 | L 3-4 | 38-22 | 1 | 32,245 | Sid Fernandez | Bryn Smith | Tim Burke | Terry Leach | | 269 | 210 | 59 |
| 1988-06-13 | vs SLN | 61 | W 2-1 | 39-22 | 1 | 37,311 | David Cone | Larry McWilliams | Randy Myers | Ken Dayley | | 271 | 211 | 60 |
| 1988-06-14 | vs SLN | 62 | W 5-0 | 40-22 | 1 | 38,042 | Bob Ojeda | Jose DeLeon | Bob Ojeda | Jose DeLeon | | 276 | 211 | 65 |
| 1988-06-15 | vs SLN | 63 | W 6-4 | 41-22 | 1 | 42,068 | Ron Darling | Cris Carpenter | Ron Darling | Cris Carpenter | Randy Myers | 282 | 215 | 67 |
| 1988-06-17 | vs PHI | 64 | L 1-3 | 41-23 | 1 | 46,502 | Dwight Gooden | Kevin Gross | Kevin Gross | Dwight Gooden | Steve Bedrosian | 283 | 218 | 65 |
| 1988-06-18 | vs PHI | 65 | W 3-2 | 42-23 | 1 | 49,307 | Sid Fernandez | Shane Rawley | Terry Leach | Todd Frohwirth | | 286 | 220 | 66 |
| 1988-06-19 | vs PHI | 66 | W 6-0 | 43-23 | 1 | 46,773 | David Cone | Don Carman | David Cone | Don Carman | | 292 | 220 | 72 |
| 1988-06-20 | vs PIT | 67 | L 5-8 | 43-24 | 1 | 42,413 | Bob Ojeda | John Smiley | John Smiley | Bob Ojeda | Jeff Robinson | 297 | 228 | 69 |
| 1988-06-21 | vs PIT | 68 | W 9-0 | 44-24 | 1 | 45,225 | Ron Darling | Doug Drabek | Ron Darling | Doug Drabek | | 306 | 228 | 78 |
| 1988-06-22 | vs PIT | 69 | W 3-0 | 45-24 | 1 | 41,816 | Dwight Gooden | Mike Dunne | Dwight Gooden | Mike Dunne | Randy Myers | 309 | 228 | 81 |
| 1988-06-23 | @ CHN | 70 | L 1-4 | 45-25 | 1 | 32,771 | Sid Fernandez | Greg Maddux | Greg Maddux | Sid Fernandez | | 310 | 232 | 78 |
| 1988-06-24 | @ CHN | 71 | W 8-3 | 46-25 | 1 | 33,588 | David Cone | Calvin Schiraldi | David Cone | Calvin Schiraldi | Roger McDowell | 318 | 235 | 83 |
| 1988-06-25 | @ CHN | 72 | L 2-5 | 46-26 | 1 | 35,828 | Bob Ojeda | Jamie Moyer | Les Lancaster | Rick Aguilera | | 320 | 240 | 80 |
| 1988-06-26 | @ CHN | 73 | L 3-6 | 46-27 | 1 | 36,009 | Ron Darling | Jeff Pico | Jeff Pico | Ron Darling | | 323 | 246 | 77 |
| 1988-06-27 | @ PIT | 74 | L 1-2 | 46-28 | 1 | 41,489 | Dwight Gooden | Mike Dunne | Mike Dunne | Dwight Gooden | Jim Gott | 324 | 248 | 76 |
| 1988-06-28 | @ PIT | 75 | W 5-2 | 47-28 | 1 | 45,011 | Sid Fernandez | Brian Fisher | Sid Fernandez | Brian Fisher | Roger McDowell | 329 | 250 | 79 |
| 1988-06-29 | @ PIT | 76 | W 8-7 | 48-28 | 1 | 41,217 | David Cone | Bob Walk | Roger McDowell | Bob Kipper | | 337 | 257 | 80 |
| 1988-06-30 | vs HOU | 77 | W 12-6 | 49-28 | 1 | 48,671 | Bob Ojeda | Danny Darwin | Bob Ojeda | Danny Darwin | Terry Leach | 349 | 263 | 86 |
| 1988-07-01 | vs HOU | 78 | W 3-2 | 50-29 | 1 | 0 | Ron Darling | Joaquin Andujar | Ron Darling | Joaquin Andujar | Randy Myers | 352 | 265 | 87 |
| 1988-07-01 | vs HOU | 79 | L 5-6 | 50-29 | 1 | 42,042 | Rick Aguilera | Jim Deshaies | Dave Meads | Gene Walter | | 357 | 271 | 86 |
| 1988-07-02 | vs HOU | 80 | W 7-2 | 51-29 | 1 | 44,715 | Dwight Gooden | Bob Knepper | Dwight Gooden | Bob Knepper | | 364 | 273 | 91 |
| 1988-07-03 | vs HOU | 81 | W 5-0 | 52-29 | 1 | 40,973 | Sid Fernandez | Nolan Ryan | Sid Fernandez | Nolan Ryan | | 369 | 273 | 96 |
| 1988-07-04 | vs CIN | 82 | L 1-5 | 52-30 | 1 | 46,609 | David Cone | Jose Rijo | Jose Rijo | David Cone | | 370 | 278 | 92 |
| 1988-07-05 | vs CIN | 83 | L 1-3 | 52-31 | 1 | 37,324 | Bob Ojeda | Tom Browning | Tom Browning | Bob Ojeda | John Franco | 371 | 281 | 90 |
| 1988-07-06 | vs CIN | 84 | W 5-4 | 53-31 | 1 | 44,146 | Ron Darling | Jack Armstrong | Ron Darling | Rob Murphy | Randy Myers | 376 | 285 | 91 |
| 1988-07-08 | @ HOU | 85 | L 2-4 | 53-32 | 1 | 34,803 | Dwight Gooden | Bob Knepper | Bob Knepper | Dwight Gooden | | 378 | 289 | 89 |
| 1988-07-09 | @ HOU | 86 | L 3-6 | 53-33 | 1 | 36,652 | Sid Fernandez | Nolan Ryan | Nolan Ryan | Rick Aguilera | Juan Agosto | 381 | 295 | 86 |
| 1988-07-10 | @ HOU | 87 | L 5-6 | 53-34 | 1 | 33,772 | David Cone | Danny Darwin | Juan Agosto | Roger McDowell | | 386 | 301 | 85 |
| 1988-07-14 | @ ATL | 88 | W 9-8 | 54-34 | 1 | 11,805 | Ron Darling | Rick Mahler | Terry Leach | Jose Alvarez | Randy Myers | 395 | 309 | 86 |
| 1988-07-15 | @ ATL | 89 | L 3-4 | 54-35 | 1 | 18,048 | David Cone | Zane Smith | Paul Assenmacher | Randy Myers | | 398 | 313 | 85 |
| 1988-07-16 | @ ATL | 90 | W 3-2 | 55-35 | 1 | 32,208 | Dwight Gooden | Pete Smith | Ed Nunez | Paul Assenmacher | Roger McDowell | 401 | 315 | 86 |
| 1988-07-17 | @ ATL | 91 | W 4-2 | 56-35 | 1 | 15,711 | Bob Ojeda | Tom Glavine | Bob Ojeda | Tom Glavine | Roger McDowell | 405 | 317 | 88 |
| 1988-07-18 | @ CIN | 92 | L 1-2 | 56-36 | 1 | 26,349 | Sid Fernandez | Danny Jackson | Danny Jackson | Sid Fernandez | John Franco | 406 | 319 | 87 |
| 1988-07-19 | @ CIN | 93 | L 2-11 | 56-37 | 1 | 28,422 | Ron Darling | Jose Rijo | Jose Rijo | Ron Darling | | 408 | 330 | 78 |
| 1988-07-22 | vs ATL | 94 | W 6-1 | 58-37 | 1 | 0 | Dwight Gooden | Tom Glavine | Dwight Gooden | Tom Glavine | | 414 | 331 | 83 |
| 1988-07-22 | vs ATL | 95 | W 5-1 | 58-37 | 1 | 37,284 | David Cone | Rick Mahler | David Cone | Rick Mahler | | 419 | 332 | 87 |
| 1988-07-23 | vs ATL | 96 | L 1-6 | 58-38 | 1 | 43,637 | Bob Ojeda | John Smoltz | John Smoltz | Bob Ojeda | | 420 | 338 | 82 |
| 1988-07-24 | vs ATL | 97 | L 2-4 | 58-39 | 1 | 46,057 | Sid Fernandez | German Jimenez | German Jimenez | Sid Fernandez | Paul Assenmacher | 422 | 342 | 80 |
| 1988-07-25 | @ PHI | 98 | L 2-3 | 58-40 | 1 | 42,701 | Ron Darling | Don Carman | Don Carman | Ron Darling | Bruce Ruffin | 424 | 345 | 79 |
| 1988-07-26 | @ PHI | 99 | W 7-5 | 59-40 | 1 | 34,192 | David Cone | Mike Maddux | Terry Leach | Greg Harris | Randy Myers | 431 | 350 | 81 |
| 1988-07-27 | @ PHI | 100 | W 10-2 | 60-40 | 1 | 36,016 | Dwight Gooden | David Palmer | Dwight Gooden | David Palmer | | 441 | 352 | 89 |
| 1988-07-29 | vs PIT | 101 | W 1-0 | 61-40 | 1 | 49,584 | Bob Ojeda | John Smiley | Bob Ojeda | John Smiley | | 442 | 352 | 90 |
| 1988-07-30 | vs PIT | 102 | W 3-0 | 62-40 | 1 | 50,815 | Sid Fernandez | Brian Fisher | Sid Fernandez | Brian Fisher | Randy Myers | 445 | 352 | 93 |
| 1988-07-31 | vs PIT | 103 | W 2-1 | 63-40 | 1 | 46,917 | Ron Darling | Bob Walk | Ron Darling | Bob Walk | | 447 | 353 | 94 |
| 1988-08-01 | vs PIT | 104 | L 2-7 | 63-41 | 1 | 52,231 | Dwight Gooden | Doug Drabek | Doug Drabek | Dwight Gooden | | 449 | 360 | 89 |
| 1988-08-02 | vs CHN | 105 | W 3-1 | 64-41 | 1 | 45,916 | David Cone | Jamie Moyer | David Cone | Jamie Moyer | | 452 | 361 | 91 |
| 1988-08-03 | vs CHN | 106 | L 1-3 | 64-42 | 1 | 41,004 | Bob Ojeda | Rick Sutcliffe | Rick Sutcliffe | Bob Ojeda | | 453 | 364 | 89 |
| 1988-08-04 | vs CHN | 107 | L 3-4 | 64-43 | 1 | 41,978 | Sid Fernandez | Calvin Schiraldi | Calvin Schiraldi | Sid Fernandez | Frank DiPino | 456 | 368 | 88 |
| 1988-08-05 | @ PIT | 108 | W 3-2 | 65-43 | 1 | 39,925 | Ron Darling | Bob Walk | Ron Darling | Bob Walk | Randy Myers | 459 | 370 | 89 |
| 1988-08-06 | @ PIT | 109 | W 5-3 | 66-43 | 1 | 48,272 | Dwight Gooden | Doug Drabek | Bob McClure | Jim Gott | Roger McDowell | 464 | 373 | 91 |
| 1988-08-07 | @ PIT | 110 | W 6-2 | 67-43 | 1 | 44,931 | David Cone | Mike Dunne | David Cone | Bob Kipper | | 470 | 375 | 95 |
| 1988-08-08 | @ PIT | 111 | L 0-1 | 67-44 | 1 | 38,307 | Bob Ojeda | Rick Reed | Rick Reed | Bob Ojeda | Jim Gott | 470 | 376 | 94 |
| 1988-08-09 | @ CHN | 112 | L 4-6 | 67-45 | 1 | 36,399 | Sid Fernandez | Mike Bielecki | Frank DiPino | Sid Fernandez | Rich Gossage | 474 | 382 | 92 |
| 1988-08-10 | @ CHN | 113 | L 5-6 | 67-46 | 1 | 29,422 | Ron Darling | Greg Maddux | Greg Maddux | Ron Darling | Frank DiPino | 479 | 388 | 91 |
| 1988-08-11 | @ CHN | 114 | W 9-6 | 68-46 | 1 | 31,942 | Dwight Gooden | Al Nipper | Terry Leach | Pat Perry | Roger McDowell | 488 | 394 | 94 |
| 1988-08-12 | vs MON | 115 | L 2-5 | 68-47 | 1 | 46,380 | David Cone | Bryn Smith | Andy McGaffigan | Randy Myers | | 490 | 399 | 91 |
| 1988-08-13 | vs MON | 116 | L 4-7 | 68-48 | 1 | 42,299 | Bob Ojeda | Pascual Perez | Pascual Perez | Bob Ojeda | Andy McGaffigan | 494 | 406 | 88 |
| 1988-08-14 | vs MON | 117 | W 4-3 | 70-48 | 1 | 0 | Ron Darling | John Dopson | Roger McDowell | Neal Heaton | | 498 | 409 | 89 |
| 1988-08-14 | vs MON | 118 | W 4-2 | 70-48 | 1 | 44,311 | Sid Fernandez | Dennis Martinez | Sid Fernandez | Dennis Martinez | Roger McDowell | 502 | 411 | 91 |
| 1988-08-16 | @ SFN | 119 | W 13-6 | 71-48 | 1 | 29,134 | Dwight Gooden | Atlee Hammaker | Dwight Gooden | Atlee Hammaker | | 515 | 417 | 98 |
| 1988-08-17 | @ SFN | 120 | L 0-4 | 71-49 | 1 | 24,730 | David Cone | Rick Reuschel | Rick Reuschel | David Cone | | 515 | 421 | 94 |
| 1988-08-18 | @ SFN | 121 | L 1-4 | 71-50 | 1 | 32,132 | Bob Ojeda | Mike Krukow | Mike Krukow | Bob Ojeda | Scott Garrelts | 516 | 425 | 91 |
| 1988-08-19 | @ SDN | 122 | L 2-3 | 71-51 | 1 | 35,327 | Sid Fernandez | Eric Show | Mark Davis | Randy Myers | | 518 | 428 | 90 |
| 1988-08-21 | @ SDN | 123 | L 0-1 | 71-52 | 1 | 29,679 | Ron Darling | Andy Hawkins | Andy Hawkins | Ron Darling | Mark Davis | 518 | 429 | 89 |
| 1988-08-22 | @ LAN | 124 | W 7-1 | 72-52 | 1 | 49,342 | Dwight Gooden | John Tudor | Dwight Gooden | John Tudor | | 525 | 430 | 95 |
| 1988-08-23 | @ LAN | 125 | W 5-1 | 73-52 | 1 | 45,512 | David Cone | Ramon Martinez | David Cone | Ramon Martinez | Randy Myers | 530 | 431 | 99 |
| 1988-08-24 | @ LAN | 126 | W 2-1 | 74-52 | 1 | 47,115 | Bob Ojeda | Orel Hershiser | Terry Leach | Orel Hershiser | Roger McDowell | 532 | 432 | 100 |
| 1988-08-26 | vs SFN | 127 | W 3-0 | 75-52 | 1 | 47,478 | Sid Fernandez | Don Robinson | Sid Fernandez | Don Robinson | Randy Myers | 535 | 432 | 103 |
| 1988-08-27 | vs SFN | 128 | W 2-1 | 76-52 | 1 | 45,115 | Ron Darling | Rick Reuschel | Ron Darling | Rick Reuschel | Randy Myers | 537 | 433 | 104 |
| 1988-08-28 | vs SFN | 129 | L 4-7 | 76-53 | 1 | 46,571 | Dwight Gooden | Mike Krukow | Scott Garrelts | Roger McDowell | | 541 | 440 | 101 |
| 1988-08-29 | vs SDN | 130 | W 6-0 | 77-53 | 1 | 16,444 | David Cone | Eric Show | David Cone | Eric Show | | 547 | 440 | 107 |
| 1988-08-30 | vs SDN | 131 | W 1-0 | 78-53 | 1 | 38,713 | Bob Ojeda | Dennis Rasmussen | Bob Ojeda | Dennis Rasmussen | | 548 | 440 | 108 |
| 1988-08-31 | vs SDN | 132 | L 3-6 | 78-54 | 1 | 36,274 | Sid Fernandez | Andy Hawkins | Andy Hawkins | Terry Leach | Mark Davis | 551 | 446 | 105 |
| 1988-09-02 | vs LAN | 133 | W 8-0 | 79-54 | 1 | 44,889 | Ron Darling | Tim Leary | Ron Darling | Tim Leary | | 559 | 446 | 113 |
| 1988-09-03 | vs LAN | 134 | W 2-1 | 80-54 | 1 | 43,896 | Dwight Gooden | John Tudor | Dwight Gooden | John Tudor | Randy Myers | 561 | 447 | 114 |
| 1988-09-05 | @ PIT | 135 | W 7-5 | 81-54 | 1 | 38,876 | David Cone | Dave LaPoint | David Cone | Jeff Robinson | Randy Myers | 568 | 452 | 116 |
| 1988-09-06 | @ PIT | 136 | L 2-3 | 81-55 | 1 | 21,296 | Bob Ojeda | John Smiley | John Smiley | Bob Ojeda | Jim Gott | 570 | 455 | 115 |
| 1988-09-07 | @ CHN | 137 | L 8-9 | 81-56 | 1 | 32,297 | Ron Darling | Jeff Pico | Rich Gossage | Roger McDowell | | 578 | 464 | 114 |
| 1988-09-08 | @ CHN | 138 | W 13-6 | 82-56 | 1 | 16,644 | Dwight Gooden | Greg Maddux | Dwight Gooden | Scott Sanderson | | 591 | 470 | 121 |
| 1988-09-09 | @ MON | 139 | W 7-3 | 83-56 | 1 | 22,496 | Sid Fernandez | Brian Holman | Terry Leach | Brian Holman | Roger McDowell | 598 | 473 | 125 |
| 1988-09-10 | @ MON | 140 | W 6-0 | 84-56 | 1 | 25,060 | David Cone | John Dopson | David Cone | John Dopson | | 604 | 473 | 131 |
| 1988-09-11 | @ MON | 141 | W 3-0 | 85-56 | 1 | 32,567 | Bob Ojeda | Dennis Martinez | Bob Ojeda | Dennis Martinez | | 607 | 473 | 134 |
| 1988-09-12 | vs PIT | 142 | W 3-2 | 86-56 | 1 | 39,576 | Ron Darling | Doug Drabek | Randy Myers | Jeff Robinson | | 610 | 475 | 135 |
| 1988-09-13 | vs PIT | 143 | L 0-1 | 86-57 | 1 | 36,633 | Dwight Gooden | Bob Walk | Bob Walk | Dwight Gooden | Jim Gott | 610 | 476 | 134 |
| 1988-09-14 | vs CHN | 144 | W 3-1 | 87-57 | 1 | 38,382 | Sid Fernandez | Calvin Schiraldi | Sid Fernandez | Calvin Schiraldi | Roger McDowell | 613 | 477 | 136 |
| 1988-09-15 | vs CHN | 145 | W 4-1 | 88-57 | 1 | 20,857 | David Cone | Rick Sutcliffe | David Cone | Rick Sutcliffe | Terry Leach | 617 | 478 | 139 |
| 1988-09-16 | vs MON | 146 | W 4-3 | 89-57 | 1 | 43,331 | Bob Ojeda | John Dopson | Randy Myers | Joe Hesketh | | 621 | 481 | 140 |
| 1988-09-17 | vs MON | 147 | W 6-2 | 90-57 | 1 | 46,109 | Ron Darling | Bryn Smith | Ron Darling | Bryn Smith | | 627 | 483 | 144 |
| 1988-09-18 | vs MON | 148 | W 5-3 | 91-57 | 1 | 45,255 | Dwight Gooden | Pascual Perez | Dwight Gooden | Pascual Perez | Randy Myers | 632 | 486 | 146 |
| 1988-09-20 | vs PHI | 149 | W 6-4 | 92-57 | 1 | 30,337 | David Cone | Shane Rawley | David Cone | Shane Rawley | | 638 | 490 | 148 |
| 1988-09-21 | vs PHI | 150 | W 4-3 | 93-57 | 1 | 35,450 | Sid Fernandez | Marvin Freeman | Sid Fernandez | Marvin Freeman | Randy Myers | 642 | 493 | 149 |
| 1988-09-22 | vs PHI | 151 | W 3-1 | 94-57 | 1 | 45,274 | Ron Darling | Don Carman | Ron Darling | Don Carman | | 645 | 494 | 151 |
| 1988-09-23 | @ SLN | 152 | L 1-2 | 94-58 | 1 | 33,290 | Dwight Gooden | Joe Magrane | John Costello | Dwight Gooden | | 646 | 496 | 150 |
| 1988-09-24 | @ SLN | 153 | W 14-1 | 95-58 | 1 | 35,670 | David West | Larry McWilliams | David West | Larry McWilliams | | 660 | 497 | 163 |
| 1988-09-25 | @ SLN | 154 | W 9-7 | 96-58 | 1 | 39,284 | David Cone | Scott Terry | David Cone | Scott Terry | Randy Myers | 669 | 504 | 165 |
| 1988-09-26 | @ PHI | 155 | W 10-4 | 97-58 | 1 | 20,694 | Sid Fernandez | Marvin Freeman | Sid Fernandez | Greg Harris | | 679 | 508 | 171 |
| 1988-09-27 | @ PHI | 156 | L 4-5 | 97-59 | 1 | 19,259 | Ron Darling | Don Carman | Steve Bedrosian | Roger McDowell | | 683 | 513 | 170 |
| 1988-09-28 | @ PHI | 157 | L 3-9 | 97-60 | 1 | 20,914 | Dwight Gooden | Kevin Gross | Kevin Gross | Dwight Gooden | | 686 | 522 | 164 |
| 1988-09-30 | vs SLN | 158 | W 4-2 | 98-60 | 1 | 38,270 | David Cone | Scott Terry | David Cone | Scott Terry | | 690 | 524 | 166 |
| 1988-10-01 | vs SLN | 159 | W 6-3 | 99-60 | 1 | 36,528 | Sid Fernandez | Jose DeLeon | Sid Fernandez | Jose DeLeon | Bob McClure | 696 | 527 | 169 |
| 1988-10-02 | vs SLN | 160 | W 7-5 | 100-60 | 1 | 42,099 | Ron Darling | Larry McWilliams | Ron Darling | Larry McWilliams | Randy Myers | 703 | 532 | 171 |