| 1988-04-04 | vs SFN | 1 | L 1-5 | 0-1 | 5 | 48,484 | Fernando Valenzuela | Dave Dravecky | Dave Dravecky | Fernando Valenzuela | | 1 | 5 | -4 |
| 1988-04-05 | vs SFN | 2 | W 5-0 | 1-1 | 3 | 37,472 | Orel Hershiser | Kelly Downs | Orel Hershiser | Kelly Downs | | 6 | 5 | 1 |
| 1988-04-07 | @ ATL | 3 | W 5-2 | 2-1 | 3 | 5,257 | Don Sutton | Pete Smith | Alejandro Pena | Paul Assenmacher | Jesse Orosco | 11 | 7 | 4 |
| 1988-04-08 | @ ATL | 4 | W 6-3 | 3-1 | 2 | 10,723 | Tim Leary | Kevin Coffman | Tim Leary | Kevin Coffman | Tim Belcher | 17 | 10 | 7 |
| 1988-04-09 | @ ATL | 5 | W 11-3 | 4-1 | 1 | 16,603 | Fernando Valenzuela | Tom Glavine | Fernando Valenzuela | Tom Glavine | | 28 | 13 | 15 |
| 1988-04-10 | @ ATL | 6 | W 3-1 | 5-1 | 1 | 14,171 | Orel Hershiser | Rick Mahler | Orel Hershiser | Rick Mahler | Jesse Orosco | 31 | 14 | 17 |
| 1988-04-12 | @ SDN | 7 | L 3-5 | 5-2 | 3 | 52,395 | Don Sutton | Andy Hawkins | Andy Hawkins | Don Sutton | Mark Davis | 34 | 19 | 15 |
| 1988-04-13 | @ SDN | 8 | W 4-3 | 6-2 | 2 | 16,838 | Tim Leary | Eric Show | Jay Howell | Eric Show | Jesse Orosco | 38 | 22 | 16 |
| 1988-04-14 | @ SDN | 9 | L 0-2 | 6-3 | 2 | 24,096 | Fernando Valenzuela | Jimmy Jones | Jimmy Jones | Fernando Valenzuela | Lance McCullers | 38 | 24 | 14 |
| 1988-04-15 | vs ATL | 10 | W 3-2 | 7-3 | 2 | 41,222 | Orel Hershiser | Tom Glavine | Orel Hershiser | Tom Glavine | | 41 | 26 | 15 |
| 1988-04-16 | vs ATL | 11 | W 7-4 | 8-3 | 1 | 27,114 | Tim Belcher | Rick Mahler | Tim Belcher | Rick Mahler | Alejandro Pena | 48 | 30 | 18 |
| 1988-04-17 | vs ATL | 12 | L 1-3 | 8-4 | 2 | 46,484 | Don Sutton | Zane Smith | Zane Smith | Don Sutton | | 49 | 33 | 16 |
| 1988-04-18 | vs SDN | 13 | W 6-0 | 9-4 | 2 | 24,357 | Tim Leary | Eric Show | Tim Leary | Eric Show | | 55 | 33 | 22 |
| 1988-04-23 | @ SFN | 14 | W 10-3 | 10-4 | 1 | 33,271 | Orel Hershiser | Mike Krukow | Orel Hershiser | Mike Krukow | | 65 | 36 | 29 |
| 1988-04-24 | @ SFN | 15 | W 4-0 | 11-4 | 1 | 39,092 | Fernando Valenzuela | Mike LaCoss | Fernando Valenzuela | Mike LaCoss | Jay Howell | 69 | 36 | 33 |
| 1988-04-26 | vs CHN | 16 | L 3-7 | 11-5 | 1 | 34,279 | Tim Leary | Greg Maddux | Greg Maddux | Tim Leary | | 72 | 43 | 29 |
| 1988-04-27 | vs CHN | 17 | W 4-0 | 12-5 | 1 | 29,462 | Don Sutton | Jamie Moyer | Don Sutton | Jamie Moyer | Alejandro Pena | 76 | 43 | 33 |
| 1988-04-28 | vs CHN | 18 | L 1-5 | 12-6 | 1 | 29,509 | Tim Belcher | Calvin Schiraldi | Calvin Schiraldi | Tim Belcher | Frank DiPino | 77 | 48 | 29 |
| 1988-04-29 | vs SLN | 19 | W 6-4 | 13-6 | 1 | 44,301 | Orel Hershiser | Danny Cox | Orel Hershiser | Danny Cox | Jay Howell | 83 | 52 | 31 |
| 1988-04-30 | vs SLN | 20 | L 2-5 | 13-7 | 2 | 47,425 | Fernando Valenzuela | Randy O'Neal | Randy O'Neal | Fernando Valenzuela | Larry McWilliams | 85 | 57 | 28 |
| 1988-05-01 | vs SLN | 21 | L 0-9 | 13-8 | 2 | 46,176 | Tim Leary | John Tudor | John Tudor | Tim Leary | Scott Terry | 85 | 66 | 19 |
| 1988-05-02 | vs PIT | 22 | W 6-3 | 14-8 | 1 | 26,821 | Don Sutton | Doug Drabek | Jesse Orosco | Doug Drabek | | 91 | 69 | 22 |
| 1988-05-03 | vs PIT | 23 | W 14-6 | 15-8 | 1 | 26,943 | Tim Belcher | Mike Dunne | Tim Belcher | Mike Dunne | | 105 | 75 | 30 |
| 1988-05-04 | vs PIT | 24 | W 8-5 | 16-8 | 1 | 30,423 | Orel Hershiser | Vicente Palacios | Orel Hershiser | Vicente Palacios | | 113 | 80 | 33 |
| 1988-05-06 | @ SLN | 25 | W 10-2 | 17-8 | 1 | 49,194 | Fernando Valenzuela | Randy O'Neal | Fernando Valenzuela | Randy O'Neal | | 123 | 82 | 41 |
| 1988-05-07 | @ SLN | 26 | L 1-2 | 17-9 | 1 | 46,159 | Tim Leary | John Tudor | Todd Worrell | Jesse Orosco | | 124 | 84 | 40 |
| 1988-05-08 | @ SLN | 27 | W 12-6 | 18-9 | 1 | 40,098 | Don Sutton | Jose DeLeon | Don Sutton | Jose DeLeon | | 136 | 90 | 46 |
| 1988-05-10 | @ CHN | 28 | W 6-5 | 19-9 | 1 | 12,985 | Tim Belcher | Rick Sutcliffe | Brian Holton | Les Lancaster | Orel Hershiser | 142 | 95 | 47 |
| 1988-05-11 | @ PIT | 29 | L 1-2 | 19-10 | 1 | 26,367 | Fernando Valenzuela | Bob Walk | Scott Medvin | Alejandro Pena | | 143 | 97 | 46 |
| 1988-05-12 | @ PIT | 30 | L 4-7 | 19-11 | 1 | 11,072 | Orel Hershiser | John Smiley | John Smiley | Orel Hershiser | | 147 | 104 | 43 |
| 1988-05-13 | vs PHI | 31 | L 1-2 | 19-12 | 1 | 38,015 | Tim Leary | Kevin Gross | Kevin Gross | Tim Leary | Kent Tekulve | 148 | 106 | 42 |
| 1988-05-14 | vs PHI | 32 | W 3-2 | 20-12 | 1 | 47,379 | Don Sutton | Bruce Ruffin | Don Sutton | Bruce Ruffin | Jay Howell | 151 | 108 | 43 |
| 1988-05-15 | vs PHI | 33 | W 9-2 | 21-12 | 1 | 41,045 | Tim Belcher | David Palmer | Tim Belcher | David Palmer | | 160 | 110 | 50 |
| 1988-05-17 | vs MON | 34 | L 5-6 | 21-13 | 1 | 34,309 | Fernando Valenzuela | Neal Heaton | Neal Heaton | Fernando Valenzuela | Tim Burke | 165 | 116 | 49 |
| 1988-05-18 | vs MON | 35 | L 0-3 | 21-14 | 1 | 27,775 | Orel Hershiser | John Dopson | John Dopson | Orel Hershiser | Tim Burke | 165 | 119 | 46 |
| 1988-05-19 | vs MON | 36 | W 2-0 | 22-14 | 1 | 25,283 | Tim Leary | Dennis Martinez | Tim Leary | Dennis Martinez | | 167 | 119 | 48 |
| 1988-05-20 | vs NYN | 37 | L 2-5 | 22-15 | 2 | 44,867 | Don Sutton | Sid Fernandez | Sid Fernandez | Don Sutton | Randy Myers | 169 | 124 | 45 |
| 1988-05-21 | vs NYN | 38 | L 0-4 | 22-16 | 2 | 47,017 | Tim Belcher | Dwight Gooden | Dwight Gooden | Tim Belcher | | 169 | 128 | 41 |
| 1988-05-22 | vs NYN | 39 | L 2-5 | 22-17 | 2 | 44,826 | Fernando Valenzuela | David Cone | David Cone | Fernando Valenzuela | Roger McDowell | 171 | 133 | 38 |
| 1988-05-24 | @ PHI | 40 | W 2-1 | 23-17 | 2 | 17,759 | Orel Hershiser | Bruce Ruffin | Alejandro Pena | Greg Harris | Jesse Orosco | 173 | 134 | 39 |
| 1988-05-25 | @ PHI | 41 | W 4-0 | 24-17 | 1 | 24,444 | Tim Leary | David Palmer | Tim Leary | David Palmer | | 177 | 134 | 43 |
| 1988-05-26 | @ PHI | 42 | W 10-8 | 25-17 | 1 | 19,361 | Don Sutton | Shane Rawley | Jay Howell | Steve Bedrosian | | 187 | 142 | 45 |
| 1988-05-27 | @ MON | 43 | W 5-2 | 26-17 | 1 | 18,113 | Tim Belcher | Floyd Youmans | Jesse Orosco | Bob McClure | Alejandro Pena | 192 | 144 | 48 |
| 1988-05-28 | @ MON | 44 | L 2-3 | 26-18 | 1 | 15,320 | Fernando Valenzuela | Neal Heaton | Jeff Parrett | Jay Howell | | 194 | 147 | 47 |
| 1988-05-29 | @ MON | 45 | W 2-1 | 27-18 | 1 | 35,311 | Orel Hershiser | John Dopson | Orel Hershiser | John Dopson | | 196 | 148 | 48 |
| 1988-05-30 | @ NYN | 46 | L 2-3 | 27-19 | 1 | 42,096 | Tim Leary | Ron Darling | Ron Darling | Tim Leary | Randy Myers | 198 | 151 | 47 |
| 1988-05-31 | @ NYN | 47 | L 4-5 | 27-20 | 1 | 35,564 | Don Sutton | Dwight Gooden | Randy Myers | Alejandro Pena | | 202 | 156 | 46 |
| 1988-06-01 | @ NYN | 48 | W 4-3 | 28-20 | 1 | 29,659 | Tim Belcher | Sid Fernandez | Brian Holton | Sid Fernandez | Jay Howell | 206 | 159 | 47 |
| 1988-06-03 | vs CIN | 49 | W 13-5 | 29-20 | 1 | 45,242 | Fernando Valenzuela | Dennis Rasmussen | Tim Crews | Dennis Rasmussen | | 219 | 164 | 55 |
| 1988-06-04 | vs CIN | 50 | L 2-5 | 29-21 | 1 | 32,550 | Orel Hershiser | Ron Robinson | Jose Rijo | Orel Hershiser | | 221 | 169 | 52 |
| 1988-06-05 | vs CIN | 51 | W 5-4 | 30-21 | 1 | 38,982 | Tim Leary | Mario Soto | Tim Leary | Mario Soto | Jay Howell | 226 | 173 | 53 |
| 1988-06-06 | vs HOU | 52 | L 4-10 | 30-22 | 1 | 19,327 | Don Sutton | Bob Knepper | Bob Knepper | Alejandro Pena | Larry Andersen | 230 | 183 | 47 |
| 1988-06-07 | vs HOU | 53 | L 2-5 | 30-23 | 1 | 25,509 | Tim Belcher | Danny Darwin | Danny Darwin | Tim Belcher | | 232 | 188 | 44 |
| 1988-06-08 | vs HOU | 54 | W 11-1 | 31-23 | 1 | 33,737 | Fernando Valenzuela | Mike Scott | Fernando Valenzuela | Mike Scott | | 243 | 189 | 54 |
| 1988-06-09 | vs HOU | 55 | W 4-2 | 32-23 | 1 | 25,959 | Orel Hershiser | Nolan Ryan | Orel Hershiser | Nolan Ryan | Jay Howell | 247 | 191 | 56 |
| 1988-06-10 | @ SDN | 56 | L 3-4 | 32-24 | 1 | 19,859 | Tim Leary | Andy Hawkins | Lance McCullers | Jay Howell | | 250 | 195 | 55 |
| 1988-06-11 | @ SDN | 57 | L 1-2 | 32-25 | 1 | 26,068 | Don Sutton | Dennis Rasmussen | Dennis Rasmussen | Don Sutton | | 251 | 197 | 54 |
| 1988-06-12 | @ SDN | 58 | L 2-5 | 32-26 | 1 | 21,533 | Tim Belcher | Ed Whitson | Ed Whitson | Tim Belcher | Mark Davis | 253 | 202 | 51 |
| 1988-06-14 | @ ATL | 59 | W 5-4 | 33-26 | 1 | 11,136 | Fernando Valenzuela | Pete Smith | Fernando Valenzuela | Pete Smith | Jay Howell | 258 | 206 | 52 |
| 1988-06-15 | @ ATL | 60 | W 7-5 | 34-26 | 1 | 10,154 | Orel Hershiser | Tom Glavine | Orel Hershiser | Tom Glavine | Alejandro Pena | 265 | 211 | 54 |
| 1988-06-16 | @ ATL | 61 | L 2-9 | 34-27 | 1 | 9,666 | Ken Howell | Zane Smith | Zane Smith | Ken Howell | | 267 | 220 | 47 |
| 1988-06-17 | vs SDN | 62 | L 4-7 | 34-29 | 1 | 0 | Tim Leary | Ed Whitson | Ed Whitson | Tim Leary | Mark Davis | 271 | 227 | 44 |
| 1988-06-17 | vs SDN | 63 | L 3-4 | 34-29 | 1 | 33,649 | Don Sutton | Dennis Rasmussen | Dennis Rasmussen | Brian Holton | Lance McCullers | 274 | 231 | 43 |
| 1988-06-18 | vs SDN | 64 | W 3-0 | 35-29 | 1 | 37,743 | Tim Belcher | Eric Show | Tim Belcher | Eric Show | Jay Howell | 277 | 231 | 46 |
| 1988-06-19 | vs SDN | 65 | W 12-2 | 37-29 | 1 | 0 | Orel Hershiser | Jimmy Jones | Orel Hershiser | Jimmy Jones | | 289 | 233 | 56 |
| 1988-06-19 | vs SDN | 66 | W 5-4 | 37-29 | 1 | 37,045 | Fernando Valenzuela | Mark Grant | Tim Crews | Mark Davis | | 294 | 237 | 57 |
| 1988-06-20 | vs ATL | 67 | W 7-3 | 38-29 | 1 | 43,268 | Shawn Hillegas | Tom Glavine | Shawn Hillegas | Tom Glavine | Alejandro Pena | 301 | 240 | 61 |
| 1988-06-21 | vs ATL | 68 | W 2-1 | 39-29 | 1 | 18,485 | Tim Leary | Zane Smith | Tim Leary | Zane Smith | | 303 | 241 | 62 |
| 1988-06-22 | vs ATL | 69 | L 1-4 | 39-30 | 1 | 27,878 | Don Sutton | Rick Mahler | Rick Mahler | Don Sutton | | 304 | 245 | 59 |
| 1988-06-24 | @ CIN | 70 | W 5-3 | 40-30 | 1 | 33,781 | Orel Hershiser | Ron Robinson | Orel Hershiser | Ron Robinson | Tim Belcher | 309 | 248 | 61 |
| 1988-06-25 | @ CIN | 71 | W 6-4 | 41-30 | 1 | 35,470 | Fernando Valenzuela | Jose Rijo | Brian Holton | Jose Rijo | Jesse Orosco | 315 | 252 | 63 |
| 1988-06-26 | @ CIN | 72 | W 9-6 | 42-30 | 1 | 29,520 | Tim Leary | Tom Browning | Tim Belcher | John Franco | Brian Holton | 324 | 258 | 66 |
| 1988-06-27 | @ HOU | 73 | W 4-0 | 43-30 | 1 | 27,185 | Shawn Hillegas | Joaquin Andujar | Shawn Hillegas | Joaquin Andujar | Alejandro Pena | 328 | 258 | 70 |
| 1988-06-28 | @ HOU | 74 | L 3-4 | 43-31 | 1 | 28,838 | Don Sutton | Bob Knepper | Bob Knepper | Brian Holton | Juan Agosto | 331 | 262 | 69 |
| 1988-06-29 | @ HOU | 75 | W 2-0 | 44-31 | 1 | 27,678 | Orel Hershiser | Nolan Ryan | Orel Hershiser | Nolan Ryan | | 333 | 262 | 71 |
| 1988-07-01 | vs CHN | 76 | L 2-9 | 44-32 | 1 | 42,763 | Fernando Valenzuela | Jamie Moyer | Jamie Moyer | Fernando Valenzuela | | 335 | 271 | 64 |
| 1988-07-02 | vs CHN | 77 | W 8-1 | 45-32 | 1 | 44,166 | Tim Leary | Jeff Pico | Tim Leary | Jeff Pico | | 343 | 272 | 71 |
| 1988-07-03 | vs CHN | 78 | L 1-2 | 45-33 | 1 | 43,209 | Shawn Hillegas | Rick Sutcliffe | Rick Sutcliffe | Shawn Hillegas | Les Lancaster | 344 | 274 | 70 |
| 1988-07-04 | vs SLN | 79 | W 5-3 | 46-33 | 1 | 44,855 | Bill Krueger | John Tudor | Alejandro Pena | John Tudor | Tim Belcher | 349 | 277 | 72 |
| 1988-07-05 | vs SLN | 80 | W 6-3 | 47-33 | 1 | 32,495 | Orel Hershiser | Danny Cox | Orel Hershiser | Danny Cox | Tim Belcher | 355 | 280 | 75 |
| 1988-07-06 | vs SLN | 81 | W 7-3 | 48-33 | 1 | 37,210 | Fernando Valenzuela | Jose DeLeon | Tim Crews | Todd Worrell | | 362 | 283 | 79 |
| 1988-07-08 | vs PIT | 82 | L 3-4 | 48-34 | 1 | 40,690 | Tim Leary | Doug Drabek | Doug Drabek | Tim Leary | Jim Gott | 365 | 287 | 78 |
| 1988-07-09 | vs PIT | 83 | L 2-8 | 48-35 | 1 | 46,662 | Shawn Hillegas | Mike Dunne | Mike Dunne | Shawn Hillegas | | 367 | 295 | 72 |
| 1988-07-10 | vs PIT | 84 | L 2-7 | 48-36 | 1 | 43,014 | Orel Hershiser | Bob Walk | Bob Walk | Orel Hershiser | | 369 | 302 | 67 |
| 1988-07-14 | @ CHN | 85 | W 1-0 | 50-36 | 1 | 0 | Tim Leary | Rick Sutcliffe | Tim Leary | Rick Sutcliffe | Alejandro Pena | 370 | 302 | 68 |
| 1988-07-14 | @ CHN | 86 | W 6-3 | 50-36 | 1 | 34,031 | Shawn Hillegas | Calvin Schiraldi | Brian Holton | Calvin Schiraldi | Jay Howell | 376 | 305 | 71 |
| 1988-07-15 | @ CHN | 87 | W 3-2 | 51-36 | 1 | 32,179 | Fernando Valenzuela | Greg Maddux | Alejandro Pena | Al Nipper | Jesse Orosco | 379 | 307 | 72 |
| 1988-07-16 | @ CHN | 88 | L 2-2 | 51-37 | 1 | 32,843 | Orel Hershiser | Jamie Moyer | | | | 381 | 309 | 72 |
| 1988-07-17 | @ CHN | 89 | W 4-1 | 53-37 | 1 | 0 | Tim Belcher | Jeff Pico | Tim Belcher | Jeff Pico | Alejandro Pena | 385 | 310 | 75 |
| 1988-07-17 | @ CHN | 90 | W 5-2 | 53-37 | 1 | 35,138 | Shawn Hillegas | Al Nipper | Brian Holton | Les Lancaster | Jay Howell | 390 | 312 | 78 |
| 1988-07-18 | @ SLN | 91 | W 1-0 | 54-37 | 1 | 29,358 | Tim Leary | Bob Forsch | Tim Leary | Todd Worrell | | 391 | 312 | 79 |
| 1988-07-19 | @ SLN | 92 | L 2-3 | 54-38 | 1 | 34,606 | William Brennan | Jose DeLeon | Jose DeLeon | William Brennan | Todd Worrell | 393 | 315 | 78 |
| 1988-07-20 | @ SLN | 93 | L 7-8 | 54-39 | 1 | 31,845 | Fernando Valenzuela | John Tudor | John Costello | Fernando Valenzuela | Todd Worrell | 400 | 323 | 77 |
| 1988-07-21 | @ PIT | 94 | L 2-3 | 54-40 | 1 | 27,510 | Orel Hershiser | Doug Drabek | Doug Drabek | Orel Hershiser | Jim Gott | 402 | 326 | 76 |
| 1988-07-22 | @ PIT | 95 | W 4-2 | 55-40 | 1 | 44,888 | Tim Belcher | Mike Dunne | Tim Belcher | Mike Dunne | Jay Howell | 406 | 328 | 78 |
| 1988-07-23 | @ PIT | 96 | W 6-2 | 56-40 | 1 | 35,817 | Tim Leary | John Smiley | Tim Leary | John Smiley | | 412 | 330 | 82 |
| 1988-07-24 | @ PIT | 97 | W 2-1 | 57-40 | 1 | 35,677 | Shawn Hillegas | Brian Fisher | Shawn Hillegas | Brian Fisher | Jay Howell | 414 | 331 | 83 |
| 1988-07-25 | @ SFN | 98 | L 1-3 | 57-41 | 1 | 29,947 | Fernando Valenzuela | Kelly Downs | Kelly Downs | Fernando Valenzuela | | 415 | 334 | 81 |
| 1988-07-26 | @ SFN | 99 | W 7-3 | 59-41 | 1 | 0 | Orel Hershiser | Terry Mulholland | Orel Hershiser | Terry Mulholland | Jay Howell | 422 | 337 | 85 |
| 1988-07-26 | @ SFN | 100 | W 6-5 | 59-41 | 1 | 49,209 | Tim Belcher | Don Robinson | Brian Holton | Scott Garrelts | | 428 | 342 | 86 |
| 1988-07-27 | @ SFN | 101 | L 1-2 | 59-42 | 1 | 34,168 | Tim Leary | Atlee Hammaker | Joe Price | Tim Leary | | 429 | 344 | 85 |
| 1988-07-29 | vs HOU | 102 | L 1-3 | 59-43 | 1 | 48,268 | Shawn Hillegas | Mike Scott | Mike Scott | Shawn Hillegas | | 430 | 347 | 83 |
| 1988-07-30 | vs HOU | 103 | L 6-14 | 59-44 | 1 | 35,835 | Fernando Valenzuela | Joaquin Andujar | Danny Darwin | Brian Holton | | 436 | 361 | 75 |
| 1988-07-31 | vs HOU | 104 | W 6-1 | 60-44 | 1 | 44,811 | Orel Hershiser | Jim Deshaies | Orel Hershiser | Jim Deshaies | | 442 | 362 | 80 |
| 1988-08-01 | vs CIN | 105 | L 3-4 | 60-45 | 1 | 45,498 | Tim Belcher | Danny Jackson | Danny Jackson | Alejandro Pena | Rob Murphy | 445 | 366 | 79 |
| 1988-08-02 | vs CIN | 106 | W 2-0 | 61-45 | 1 | 44,091 | Tim Leary | Jose Rijo | Tim Leary | Jose Rijo | | 447 | 366 | 81 |
| 1988-08-03 | vs CIN | 107 | L 4-7 | 61-46 | 1 | 41,535 | Shawn Hillegas | Tom Browning | John Franco | Alejandro Pena | Rob Murphy | 451 | 373 | 78 |
| 1988-08-05 | @ HOU | 108 | L 4-6 | 61-47 | 1 | 43,426 | Orel Hershiser | Jim Deshaies | Jim Deshaies | Orel Hershiser | Dave Smith | 455 | 379 | 76 |
| 1988-08-06 | @ HOU | 109 | W 5-3 | 62-47 | 1 | 43,521 | Tim Belcher | Nolan Ryan | Tim Belcher | Nolan Ryan | Jay Howell | 460 | 382 | 78 |
| 1988-08-07 | @ HOU | 110 | L 2-4 | 62-48 | 1 | 40,339 | Tim Leary | Bob Knepper | Bob Knepper | Tim Leary | Juan Agosto | 462 | 386 | 76 |
| 1988-08-08 | @ HOU | 111 | L 0-10 | 62-49 | 1 | 39,786 | Shawn Hillegas | Mike Scott | Mike Scott | Shawn Hillegas | | 462 | 396 | 66 |
| 1988-08-09 | @ CIN | 112 | L 0-6 | 62-50 | 2 | 32,824 | Don Sutton | Danny Jackson | Danny Jackson | Don Sutton | | 462 | 402 | 60 |
| 1988-08-10 | @ CIN | 113 | W 8-5 | 63-50 | 1 | 30,809 | Orel Hershiser | Jose Rijo | Orel Hershiser | Jose Rijo | | 470 | 407 | 63 |
| 1988-08-11 | @ CIN | 114 | L 8-9 | 63-51 | 1 | 30,695 | Tim Belcher | Tom Browning | John Franco | Jay Howell | | 478 | 416 | 62 |
| 1988-08-12 | vs SFN | 115 | W 7-3 | 64-51 | 1 | 48,744 | Tim Leary | Rick Reuschel | Tim Leary | Rick Reuschel | Alejandro Pena | 485 | 419 | 66 |
| 1988-08-13 | vs SFN | 116 | W 2-1 | 65-51 | 1 | 47,649 | Ramon Martinez | Mike Krukow | Alejandro Pena | Joe Price | | 487 | 420 | 67 |
| 1988-08-14 | vs SFN | 117 | L 4-15 | 65-52 | 1 | 45,502 | Orel Hershiser | Kelly Downs | Kelly Downs | Orel Hershiser | Jeff Brantley | 491 | 435 | 56 |
| 1988-08-15 | vs SFN | 118 | W 1-0 | 66-52 | 1 | 49,306 | Tim Belcher | Don Robinson | Tim Belcher | Don Robinson | Jesse Orosco | 492 | 435 | 57 |
| 1988-08-16 | vs PHI | 119 | W 7-5 | 67-52 | 1 | 32,482 | Tim Leary | Don Carman | Tim Leary | Don Carman | Jay Howell | 499 | 440 | 59 |
| 1988-08-17 | vs PHI | 120 | W 7-2 | 68-52 | 1 | 42,701 | John Tudor | Mike Maddux | John Tudor | Mike Maddux | | 506 | 442 | 64 |
| 1988-08-18 | vs PHI | 121 | W 2-1 | 69-52 | 1 | 34,467 | Ramon Martinez | Kevin Gross | Jay Howell | Kevin Gross | Jesse Orosco | 508 | 443 | 65 |
| 1988-08-19 | vs MON | 122 | W 2-0 | 70-52 | 1 | 36,217 | Orel Hershiser | Dennis Martinez | Orel Hershiser | Dennis Martinez | | 510 | 443 | 67 |
| 1988-08-20 | vs MON | 123 | W 4-3 | 71-52 | 1 | 46,743 | Tim Belcher | John Dopson | Jay Howell | Joe Hesketh | | 514 | 446 | 68 |
| 1988-08-21 | vs MON | 124 | W 4-0 | 72-52 | 1 | 39,505 | Tim Leary | Neal Heaton | Tim Leary | Neal Heaton | | 518 | 446 | 72 |
| 1988-08-22 | vs NYN | 125 | L 1-7 | 72-53 | 1 | 49,342 | John Tudor | Dwight Gooden | Dwight Gooden | John Tudor | | 519 | 453 | 66 |
| 1988-08-23 | vs NYN | 126 | L 1-5 | 72-54 | 1 | 45,512 | Ramon Martinez | David Cone | David Cone | Ramon Martinez | Randy Myers | 520 | 458 | 62 |
| 1988-08-24 | vs NYN | 127 | L 1-2 | 72-55 | 1 | 47,115 | Orel Hershiser | Bob Ojeda | Terry Leach | Orel Hershiser | Roger McDowell | 521 | 460 | 61 |
| 1988-08-26 | @ PHI | 128 | W 7-2 | 73-55 | 1 | 27,533 | Tim Belcher | Marvin Freeman | Tim Belcher | Marvin Freeman | | 528 | 462 | 66 |
| 1988-08-27 | @ PHI | 129 | W 4-2 | 74-55 | 1 | 27,324 | Tim Leary | Don Carman | Tim Leary | Don Carman | Jay Howell | 532 | 464 | 68 |
| 1988-08-28 | @ PHI | 130 | W 5-0 | 75-55 | 1 | 28,570 | John Tudor | Kevin Gross | John Tudor | Kevin Gross | | 537 | 464 | 73 |
| 1988-08-29 | @ MON | 131 | W 2-1 | 76-55 | 1 | 16,002 | Ramon Martinez | Dennis Martinez | Ramon Martinez | Dennis Martinez | Jay Howell | 539 | 465 | 74 |
| 1988-08-30 | @ MON | 132 | W 4-2 | 77-55 | 1 | 21,454 | Orel Hershiser | Brian Holman | Orel Hershiser | Brian Holman | | 543 | 467 | 76 |
| 1988-08-31 | @ MON | 133 | L 3-4 | 77-56 | 1 | 12,068 | Tim Belcher | John Dopson | Jeff Parrett | Alejandro Pena | | 546 | 471 | 75 |
| 1988-09-02 | @ NYN | 134 | L 0-8 | 77-57 | 1 | 44,889 | Tim Leary | Ron Darling | Ron Darling | Tim Leary | | 546 | 479 | 67 |
| 1988-09-03 | @ NYN | 135 | L 1-2 | 77-58 | 1 | 43,896 | John Tudor | Dwight Gooden | Dwight Gooden | John Tudor | Randy Myers | 547 | 481 | 66 |
| 1988-09-05 | @ ATL | 136 | W 3-0 | 78-58 | 1 | 10,768 | Orel Hershiser | Rick Mahler | Orel Hershiser | Rick Mahler | | 550 | 481 | 69 |
| 1988-09-06 | @ ATL | 137 | L 1-2 | 78-59 | 1 | 7,245 | Tim Belcher | Pete Smith | Paul Assenmacher | Jesse Orosco | Bruce Sutter | 551 | 483 | 68 |
| 1988-09-07 | vs HOU | 138 | W 4-1 | 79-59 | 1 | 35,874 | Tim Leary | Mike Scott | Tim Leary | Mike Scott | Jay Howell | 555 | 484 | 71 |
| 1988-09-08 | vs HOU | 139 | L 1-2 | 79-60 | 1 | 36,504 | John Tudor | Nolan Ryan | Nolan Ryan | John Tudor | | 556 | 486 | 70 |
| 1988-09-09 | vs CIN | 140 | L 2-5 | 79-61 | 1 | 42,557 | Ramon Martinez | Danny Jackson | Danny Jackson | Ramon Martinez | | 558 | 491 | 67 |
| 1988-09-10 | vs CIN | 141 | W 5-0 | 80-61 | 1 | 42,393 | Orel Hershiser | Norm Charlton | Orel Hershiser | Norm Charlton | | 563 | 491 | 72 |
| 1988-09-11 | vs CIN | 142 | W 5-3 | 81-61 | 1 | 40,635 | Tim Belcher | Tom Browning | Tim Crews | John Franco | | 568 | 494 | 74 |
| 1988-09-12 | vs ATL | 143 | W 5-4 | 82-61 | 1 | 24,578 | Tim Leary | Tom Glavine | Tim Leary | Tom Glavine | Alejandro Pena | 573 | 498 | 75 |
| 1988-09-13 | vs ATL | 144 | W 2-0 | 83-61 | 1 | 22,758 | John Tudor | John Smoltz | John Tudor | John Smoltz | Jay Howell | 575 | 498 | 77 |
| 1988-09-14 | vs ATL | 145 | W 1-0 | 84-61 | 1 | 42,434 | Orel Hershiser | Rick Mahler | Orel Hershiser | Rick Mahler | | 576 | 498 | 78 |
| 1988-09-16 | @ CIN | 146 | L 0-1 | 84-62 | 1 | 16,591 | Tim Belcher | Tom Browning | Tom Browning | Tim Belcher | | 576 | 499 | 77 |
| 1988-09-17 | @ CIN | 147 | W 4-3 | 85-62 | 1 | 31,328 | Tim Leary | Ron Robinson | Jesse Orosco | Rob Murphy | Jay Howell | 580 | 502 | 78 |
| 1988-09-18 | @ CIN | 148 | W 2-0 | 86-62 | 1 | 24,156 | John Tudor | Jose Rijo | John Tudor | Frank Williams | Alejandro Pena | 582 | 502 | 80 |
| 1988-09-19 | @ HOU | 149 | W 1-0 | 87-62 | 1 | 16,173 | Orel Hershiser | Nolan Ryan | Orel Hershiser | Danny Darwin | | 583 | 502 | 81 |
| 1988-09-20 | @ HOU | 150 | W 6-0 | 88-62 | 1 | 12,291 | Tim Belcher | Bob Forsch | Tim Belcher | Bob Forsch | | 589 | 502 | 87 |
| 1988-09-21 | vs SDN | 151 | L 3-9 | 89-63 | 1 | 0 | Ramon Martinez | Dennis Rasmussen | Dennis Rasmussen | Ramon Martinez | | 592 | 511 | 81 |
| 1988-09-21 | vs SDN | 152 | W 6-5 | 89-63 | 1 | 31,120 | William Brennan | Greg Booker | Jay Howell | Mark Davis | | 598 | 516 | 82 |
| 1988-09-22 | vs SDN | 153 | L 4-5 | 89-64 | 1 | 30,074 | Tim Leary | Eric Show | Eric Show | Alejandro Pena | | 602 | 521 | 81 |
| 1988-09-23 | @ SFN | 154 | W 3-0 | 90-64 | 1 | 22,341 | Orel Hershiser | Atlee Hammaker | Orel Hershiser | Atlee Hammaker | | 605 | 521 | 84 |
| 1988-09-24 | @ SFN | 155 | W 7-3 | 91-64 | 1 | 34,214 | John Tudor | Trevor Wilson | Ricky Horton | Trevor Wilson | Jesse Orosco | 612 | 524 | 88 |
| 1988-09-25 | @ SFN | 156 | L 0-2 | 91-65 | 1 | 40,743 | Tim Belcher | Dennis Cook | Dennis Cook | Tim Belcher | | 612 | 526 | 86 |
| 1988-09-26 | @ SDN | 157 | W 3-2 | 92-65 | 1 | 18,552 | Fernando Valenzuela | Dennis Rasmussen | Alejandro Pena | Dennis Rasmussen | Jay Howell | 615 | 528 | 87 |
| 1988-09-27 | @ SDN | 158 | L 4-8 | 92-66 | 1 | 13,235 | Tim Leary | Eric Show | Eric Show | Tim Leary | | 619 | 536 | 83 |
| 1988-09-28 | @ SDN | 159 | L 1-2 | 92-67 | 1 | 22,596 | Orel Hershiser | Andy Hawkins | Dave Leiper | Ricky Horton | | 620 | 538 | 82 |
| 1988-09-30 | vs SFN | 160 | W 6-4 | 93-67 | 1 | 42,580 | John Tudor | Dennis Cook | Brian Holton | Dennis Cook | Alejandro Pena | 626 | 542 | 84 |
| 1988-10-01 | vs SFN | 161 | W 2-1 | 94-67 | 1 | 33,951 | Tim Belcher | Rick Reuschel | Tim Belcher | Rick Reuschel | Fernando Valenzuela | 628 | 543 | 85 |
| 1988-10-02 | vs SFN | 162 | L 0-1 | 94-68 | 1 | 44,055 | Tim Leary | Don Robinson | Don Robinson | Tim Leary | | 628 | 544 | 84 |