| 1987-04-06 | @ TOR | 1 | L 3-7 | 0-1 | 6 | 40,404 | Tom Candiotti | Jimmy Key | Jimmy Key | Tom Candiotti | | 3 | 7 | -4 |
| 1987-04-08 | @ TOR | 2 | L 1-5 | 0-2 | 6 | 20,388 | Greg Swindell | Jim Clancy | Jim Clancy | Greg Swindell | | 4 | 12 | -8 |
| 1987-04-09 | @ TOR | 3 | W 14-3 | 1-2 | 5 | 21,088 | Phil Niekro | Joe Johnson | Phil Niekro | Joe Johnson | Steve Carlton | 18 | 15 | 3 |
| 1987-04-10 | vs BAL | 4 | L 11-12 | 1-3 | 7 | 64,540 | Scott Bailes | Mike Flanagan | Mark Williamson | Ernie Camacho | | 29 | 27 | 2 |
| 1987-04-11 | vs BAL | 5 | L 3-7 | 1-4 | 7 | 21,616 | Tom Candiotti | Mike Boddicker | Dave J. Schmidt | Tom Candiotti | | 32 | 34 | -2 |
| 1987-04-12 | vs BAL | 6 | L 1-7 | 1-5 | 7 | 15,257 | Ken Schrom | Eric Bell | Eric Bell | Ken Schrom | | 33 | 41 | -8 |
| 1987-04-13 | @ NYA | 7 | L 3-11 | 1-6 | 7 | 55,612 | Greg Swindell | Charles Hudson | Charles Hudson | Greg Swindell | | 36 | 52 | -16 |
| 1987-04-14 | @ NYA | 8 | L 6-10 | 1-7 | 7 | 20,129 | Phil Niekro | Bob Tewksbury | Cecilio Guante | Steve Carlton | | 42 | 62 | -20 |
| 1987-04-15 | @ NYA | 9 | L 3-4 | 1-8 | 7 | 20,051 | Scott Bailes | Rick Rhoden | Rick Rhoden | Tom Waddell | Dave Righetti | 45 | 66 | -21 |
| 1987-04-17 | @ BAL | 10 | L 1-4 | 1-9 | 7 | 15,213 | Tom Candiotti | Mike Boddicker | Mike Boddicker | Tom Candiotti | Mark Williamson | 46 | 70 | -24 |
| 1987-04-18 | @ BAL | 11 | L 3-16 | 1-10 | 7 | 20,388 | Ken Schrom | Eric Bell | Eric Bell | Ken Schrom | Dave J. Schmidt | 49 | 86 | -37 |
| 1987-04-19 | @ BAL | 12 | W 3-0 | 3-10 | 7 | 0 | Greg Swindell | Scott McGregor | Greg Swindell | Scott McGregor | | 52 | 86 | -34 |
| 1987-04-19 | @ BAL | 13 | W 8-7 | 3-10 | 7 | 21,504 | Phil Niekro | Ken Dixon | Steve Carlton | Mark Williamson | Ernie Camacho | 60 | 93 | -33 |
| 1987-04-20 | vs TOR | 14 | L 7-8 | 3-11 | 7 | 11,164 | Scott Bailes | Dave Stieb | Jeff Musselman | Doug Jones | | 67 | 101 | -34 |
| 1987-04-21 | vs TOR | 15 | W 5-0 | 4-11 | 7 | 7,203 | Tom Candiotti | Jimmy Key | Tom Candiotti | Jimmy Key | | 72 | 101 | -29 |
| 1987-04-22 | vs TOR | 16 | L 3-6 | 4-12 | 7 | 6,000 | Ken Schrom | Jim Clancy | Mark Eichhorn | Steve Carlton | Tom Henke | 75 | 107 | -32 |
| 1987-04-23 | vs NYA | 17 | L 4-5 | 4-13 | 7 | 8,157 | Greg Swindell | Dennis Rasmussen | Dennis Rasmussen | Greg Swindell | Dave Righetti | 79 | 112 | -33 |
| 1987-04-24 | vs NYA | 18 | W 6-5 | 5-13 | 7 | 14,336 | Phil Niekro | Charles Hudson | Steve Carlton | Dave Righetti | | 85 | 117 | -32 |
| 1987-04-25 | vs NYA | 19 | W 2-1 | 6-13 | 7 | 17,207 | Scott Bailes | Rick Rhoden | Scott Bailes | Rick Rhoden | Frank Wills | 87 | 118 | -31 |
| 1987-04-26 | vs NYA | 20 | L 2-14 | 6-14 | 7 | 25,108 | Tom Candiotti | Tommy John | Tommy John | Tom Candiotti | | 89 | 132 | -43 |
| 1987-04-28 | vs CHA | 21 | W 1-0 | 7-14 | 7 | 4,398 | Ken Schrom | Joel Davis | Ken Schrom | Joel Davis | | 90 | 132 | -42 |
| 1987-04-29 | vs CHA | 22 | W 6-5 | 8-14 | 7 | 6,695 | Greg Swindell | Richard Dotson | Rich Yett | Bob James | | 96 | 137 | -41 |
| 1987-05-01 | @ KCA | 23 | W 2-0 | 9-14 | 7 | 27,281 | Phil Niekro | Mark Gubicza | Phil Niekro | Mark Gubicza | Rich Yett | 98 | 137 | -39 |
| 1987-05-02 | @ KCA | 24 | L 4-5 | 9-15 | 7 | 29,548 | Scott Bailes | Bret Saberhagen | Bret Saberhagen | Rich Yett | Dan Quisenberry | 102 | 142 | -40 |
| 1987-05-03 | @ KCA | 25 | L 1-2 | 9-16 | 7 | 27,829 | Ken Schrom | Danny Jackson | Danny Jackson | Ken Schrom | | 103 | 144 | -41 |
| 1987-05-05 | @ TEX | 26 | L 5-6 | 9-17 | 7 | 25,955 | Greg Swindell | Mike Mason | Mitch Williams | Frank Wills | | 108 | 150 | -42 |
| 1987-05-06 | @ TEX | 27 | L 2-7 | 9-18 | 7 | 27,350 | Phil Niekro | Charlie Hough | Charlie Hough | Phil Niekro | | 110 | 157 | -47 |
| 1987-05-08 | vs KCA | 28 | L 6-9 | 9-19 | 7 | 32,720 | Ken Schrom | Mark Gubicza | Mark Gubicza | Ken Schrom | Dan Quisenberry | 116 | 166 | -50 |
| 1987-05-09 | vs KCA | 29 | L 0-4 | 9-20 | 7 | 12,051 | Tom Candiotti | Bret Saberhagen | Bret Saberhagen | Tom Candiotti | | 116 | 170 | -54 |
| 1987-05-10 | vs KCA | 30 | W 4-2 | 10-20 | 7 | 14,430 | Greg Swindell | Danny Jackson | Greg Swindell | Danny Jackson | | 120 | 172 | -52 |
| 1987-05-11 | vs TEX | 31 | L 3-6 | 10-21 | 7 | 6,397 | Phil Niekro | Mike Mason | Ron Meridith | Phil Niekro | Mike Loynd | 123 | 178 | -55 |
| 1987-05-12 | vs TEX | 32 | L 1-6 | 10-22 | 7 | 6,370 | Steve Carlton | Charlie Hough | Charlie Hough | Steve Carlton | | 124 | 184 | -60 |
| 1987-05-13 | @ CHA | 33 | W 7-5 | 11-22 | 7 | 11,834 | Ken Schrom | Jose DeLeon | Ken Schrom | Jose DeLeon | Scott Bailes | 131 | 189 | -58 |
| 1987-05-14 | @ CHA | 34 | L 3-4 | 11-23 | 7 | 9,115 | Tom Candiotti | Joel Davis | Bobby Thigpen | Rich Yett | | 134 | 193 | -59 |
| 1987-05-15 | @ DET | 35 | L 3-4 | 11-24 | 7 | 17,525 | Greg Swindell | Eric King | Mike Henneman | Mark Huismann | | 137 | 197 | -60 |
| 1987-05-16 | @ DET | 36 | L 3-5 | 11-25 | 7 | 20,583 | Phil Niekro | Jack Morris | Jack Morris | Phil Niekro | | 140 | 202 | -62 |
| 1987-05-17 | @ DET | 37 | L 4-8 | 11-26 | 7 | 20,824 | Steve Carlton | Walt Terrell | Walt Terrell | Steve Carlton | | 144 | 210 | -66 |
| 1987-05-19 | vs MIN | 38 | W 4-3 | 12-26 | 7 | 7,045 | Ken Schrom | Les Straker | Ken Schrom | Mark Portugal | | 148 | 213 | -65 |
| 1987-05-20 | vs MIN | 39 | L 2-8 | 12-27 | 7 | 6,226 | Tom Candiotti | Juan Berenguer | Juan Berenguer | Tom Candiotti | | 150 | 221 | -71 |
| 1987-05-21 | vs MIN | 40 | W 6-3 | 13-27 | 7 | 7,401 | Greg Swindell | Bert Blyleven | Greg Swindell | Bert Blyleven | | 156 | 224 | -68 |
| 1987-05-22 | @ MIL | 41 | L 2-4 | 13-28 | 7 | 15,017 | Phil Niekro | Bill Wegman | Bill Wegman | Phil Niekro | Dan Plesac | 158 | 228 | -70 |
| 1987-05-23 | @ MIL | 42 | W 6-2 | 14-28 | 7 | 27,234 | Steve Carlton | Mike Birkbeck | Steve Carlton | Mike Birkbeck | | 164 | 230 | -66 |
| 1987-05-24 | @ MIL | 43 | W 5-3 | 15-28 | 7 | 36,338 | Ken Schrom | Teddy Higuera | Ken Schrom | Teddy Higuera | Scott Bailes | 169 | 233 | -64 |
| 1987-05-25 | @ BOS | 44 | L 6-10 | 15-29 | 7 | 19,858 | Tom Candiotti | Bruce Hurst | Steve Crawford | Mark Huismann | | 175 | 243 | -68 |
| 1987-05-26 | @ BOS | 45 | L 5-6 | 15-30 | 7 | 18,493 | Greg Swindell | Al Nipper | Al Nipper | Greg Swindell | | 180 | 249 | -69 |
| 1987-05-27 | @ BOS | 46 | L 0-1 | 15-31 | 7 | 22,906 | Phil Niekro | Roger Clemens | Roger Clemens | Phil Niekro | | 180 | 250 | -70 |
| 1987-05-28 | @ BOS | 47 | L 8-12 | 15-32 | 7 | 22,305 | Steve Carlton | John Leister | Steve Crawford | Rich Yett | Wes Gardner | 188 | 262 | -74 |
| 1987-05-29 | vs MIL | 48 | W 9-6 | 16-32 | 7 | 47,442 | Ken Schrom | Teddy Higuera | Scott Bailes | Teddy Higuera | | 197 | 268 | -71 |
| 1987-05-30 | vs MIL | 49 | L 5-6 | 16-33 | 7 | 13,619 | Tom Candiotti | Len Barker | Mark Clear | Mark Huismann | Dan Plesac | 202 | 274 | -72 |
| 1987-05-31 | vs MIL | 50 | L 1-7 | 16-34 | 7 | 12,831 | Greg Swindell | Juan Nieves | Juan Nieves | Greg Swindell | | 203 | 281 | -78 |
| 1987-06-01 | vs DET | 51 | W 9-6 | 17-34 | 7 | 6,509 | Phil Niekro | Dan Petry | Phil Niekro | Dan Petry | Scott Bailes | 212 | 287 | -75 |
| 1987-06-03 | vs DET | 52 | L 3-15 | 17-35 | 7 | 8,226 | Ken Schrom | Jack Morris | Jack Morris | Ken Schrom | | 215 | 302 | -87 |
| 1987-06-05 | @ OAK | 53 | W 4-3 | 18-35 | 7 | 13,937 | Tom Candiotti | Joaquin Andujar | Tom Candiotti | Joaquin Andujar | Scott Bailes | 219 | 305 | -86 |
| 1987-06-06 | @ OAK | 54 | L 4-6 | 18-36 | 7 | 16,728 | Greg Swindell | Moose Haas | Dennis Eckersley | Greg Swindell | | 223 | 311 | -88 |
| 1987-06-07 | @ OAK | 55 | W 12-2 | 19-36 | 7 | 30,118 | Steve Carlton | Dave Stewart | Steve Carlton | Dave Stewart | | 235 | 313 | -78 |
| 1987-06-08 | @ CAL | 56 | W 2-0 | 20-36 | 7 | 23,752 | Phil Niekro | Don Sutton | Phil Niekro | Don Sutton | Scott Bailes | 237 | 313 | -76 |
| 1987-06-09 | @ CAL | 57 | L 5-6 | 20-37 | 7 | 23,252 | Ken Schrom | Jack Lazorko | Jack Lazorko | Rich Yett | DeWayne Buice | 242 | 319 | -77 |
| 1987-06-10 | @ CAL | 58 | L 7-10 | 20-38 | 7 | 24,467 | Tom Candiotti | John Candelaria | Greg Minton | Scott Bailes | | 249 | 329 | -80 |
| 1987-06-12 | @ SEA | 59 | W 10-6 | 21-38 | 7 | 11,561 | Greg Swindell | Scott Bankhead | Mark Huismann | Mike Trujillo | | 259 | 335 | -76 |
| 1987-06-13 | @ SEA | 60 | W 6-1 | 22-38 | 7 | 14,013 | Phil Niekro | Mark Langston | Phil Niekro | Mark Langston | | 265 | 336 | -71 |
| 1987-06-14 | @ SEA | 61 | L 3-4 | 22-39 | 7 | 12,296 | Steve Carlton | Mike Morgan | Ed Nunez | Rich Yett | | 268 | 340 | -72 |
| 1987-06-16 | vs BOS | 62 | W 8-7 | 23-39 | 7 | 17,949 | Ken Schrom | Al Nipper | Mark Huismann | Al Nipper | Mike Armstrong | 276 | 347 | -71 |
| 1987-06-17 | vs BOS | 63 | L 0-4 | 23-40 | 7 | 12,910 | Tom Candiotti | Roger Clemens | Roger Clemens | Tom Candiotti | | 276 | 351 | -75 |
| 1987-06-18 | vs BOS | 64 | W 7-5 | 24-40 | 7 | 11,000 | Rich Yett | Bob Stanley | Mike Armstrong | Bob Stanley | Mark Huismann | 283 | 356 | -73 |
| 1987-06-19 | vs SEA | 65 | L 4-7 | 24-41 | 7 | 57,386 | Phil Niekro | Mark Langston | Mark Langston | Phil Niekro | | 287 | 363 | -76 |
| 1987-06-20 | vs SEA | 66 | W 9-2 | 25-41 | 7 | 12,307 | Steve Carlton | Mike Morgan | Steve Carlton | Mike Morgan | | 296 | 365 | -69 |
| 1987-06-21 | vs SEA | 67 | L 0-5 | 25-42 | 7 | 14,494 | Ken Schrom | Lee Guetterman | Lee Guetterman | Ken Schrom | | 296 | 370 | -74 |
| 1987-06-23 | @ MIN | 68 | L 4-9 | 25-43 | 7 | 17,393 | Tom Candiotti | Mike Smithson | Mike Smithson | Tom Candiotti | George Frazier | 300 | 379 | -79 |
| 1987-06-24 | @ MIN | 69 | L 8-14 | 25-44 | 7 | 19,885 | Greg Swindell | Les Straker | Les Straker | Greg Swindell | | 308 | 393 | -85 |
| 1987-06-25 | @ MIN | 70 | L 3-4 | 25-45 | 7 | 27,489 | Phil Niekro | Bert Blyleven | Bert Blyleven | Phil Niekro | Jeff Reardon | 311 | 397 | -86 |
| 1987-06-26 | vs OAK | 71 | L 0-5 | 25-46 | 7 | 15,387 | Steve Carlton | Dave Stewart | Dave Stewart | Steve Carlton | Gene Nelson | 311 | 402 | -91 |
| 1987-06-27 | vs OAK | 72 | L 3-13 | 25-47 | 7 | 13,086 | Ken Schrom | Joaquin Andujar | Joaquin Andujar | Ken Schrom | | 314 | 415 | -101 |
| 1987-06-28 | vs OAK | 73 | L 0-10 | 25-48 | 7 | 17,762 | Tom Candiotti | Steve Ontiveros | Steve Ontiveros | Tom Candiotti | | 314 | 425 | -111 |
| 1987-06-29 | vs CAL | 74 | L 4-11 | 25-49 | 7 | 5,888 | Greg Swindell | Don Sutton | Don Sutton | Greg Swindell | Greg Minton | 318 | 436 | -118 |
| 1987-06-30 | vs CAL | 75 | W 2-1 | 26-49 | 7 | 12,337 | Phil Niekro | Jack Lazorko | Phil Niekro | Jack Lazorko | Scott Bailes | 320 | 437 | -117 |
| 1987-07-01 | vs CAL | 76 | L 5-10 | 26-50 | 7 | 5,005 | Steve Carlton | Jerry Reuss | Jerry Reuss | Steve Carlton | DeWayne Buice | 325 | 447 | -122 |
| 1987-07-02 | vs CHA | 77 | W 2-1 | 27-50 | 7 | 6,835 | Ken Schrom | Floyd Bannister | Doug Jones | Bob James | | 327 | 448 | -121 |
| 1987-07-03 | vs CHA | 78 | L 9-14 | 27-51 | 7 | 26,540 | Tom Candiotti | Bill Long | Jim Winn | Sammy Stewart | | 336 | 462 | -126 |
| 1987-07-04 | vs CHA | 79 | L 2-3 | 27-52 | 7 | 12,341 | Scott Bailes | Richard Dotson | Richard Dotson | Scott Bailes | Bob James | 338 | 465 | -127 |
| 1987-07-05 | vs CHA | 80 | L 0-17 | 27-53 | 7 | 10,084 | Phil Niekro | Scott Nielsen | Scott Nielsen | Phil Niekro | | 338 | 482 | -144 |
| 1987-07-06 | vs KCA | 81 | W 9-7 | 28-53 | 7 | 6,332 | Steve Carlton | Bret Saberhagen | Sammy Stewart | Bret Saberhagen | Mark Huismann | 347 | 489 | -142 |
| 1987-07-07 | vs KCA | 82 | W 6-4 | 29-53 | 7 | 8,012 | Ken Schrom | Mark Gubicza | Doug Jones | Dan Quisenberry | | 353 | 493 | -140 |
| 1987-07-08 | vs KCA | 83 | W 9-8 | 30-53 | 7 | 9,528 | Tom Candiotti | Danny Jackson | Sammy Stewart | Jerry Gleaton | | 362 | 501 | -139 |
| 1987-07-09 | @ TEX | 84 | W 10-4 | 31-53 | 7 | 20,731 | Scott Bailes | Jose Guzman | Doug Jones | Jose Guzman | | 372 | 505 | -133 |
| 1987-07-10 | @ TEX | 85 | L 4-10 | 31-54 | 7 | 18,112 | Phil Niekro | Greg Harris | Greg Harris | Phil Niekro | | 376 | 515 | -139 |
| 1987-07-11 | @ TEX | 86 | L 2-6 | 31-55 | 7 | 36,392 | Steve Carlton | Charlie Hough | Charlie Hough | Steve Carlton | Jeff Russell | 378 | 521 | -143 |
| 1987-07-12 | @ TEX | 87 | L 6-7 | 31-56 | 7 | 14,809 | Ken Schrom | Mike Loynd | Jose Guzman | Doug Jones | Dale Mohorcic | 384 | 528 | -144 |
| 1987-07-16 | @ CHA | 88 | W 4-3 | 32-56 | 7 | 14,752 | Scott Bailes | Richard Dotson | Scott Bailes | Richard Dotson | Sammy Stewart | 388 | 531 | -143 |
| 1987-07-17 | @ CHA | 89 | L 3-4 | 32-57 | 7 | 19,446 | Ken Schrom | Jose DeLeon | Bob James | Doug Jones | | 391 | 535 | -144 |
| 1987-07-18 | @ CHA | 90 | L 3-6 | 32-58 | 7 | 21,866 | Tom Candiotti | Floyd Bannister | Bobby Thigpen | Tom Candiotti | Jim Winn | 394 | 541 | -147 |
| 1987-07-19 | @ CHA | 91 | L 7-9 | 32-59 | 7 | 14,078 | Steve Carlton | Bill Long | Scott Nielsen | Steve Carlton | Jim Winn | 401 | 550 | -149 |
| 1987-07-20 | @ KCA | 92 | W 9-5 | 33-59 | 7 | 35,164 | Phil Niekro | Bret Saberhagen | Phil Niekro | Bret Saberhagen | Doug Jones | 410 | 555 | -145 |
| 1987-07-21 | @ KCA | 93 | L 2-3 | 33-60 | 7 | 26,880 | Scott Bailes | Charlie Leibrandt | Charlie Leibrandt | Scott Bailes | | 412 | 558 | -146 |
| 1987-07-22 | @ KCA | 94 | L 1-5 | 33-61 | 7 | 24,570 | Darrel Akerfelds | Mark Gubicza | Mark Gubicza | Darrel Akerfelds | | 413 | 563 | -150 |
| 1987-07-23 | vs TEX | 95 | W 4-2 | 34-61 | 7 | 7,888 | Tom Candiotti | Jose Guzman | Tom Candiotti | Jose Guzman | | 417 | 565 | -148 |
| 1987-07-24 | vs TEX | 96 | L 3-6 | 34-62 | 7 | 10,664 | Steve Carlton | Greg Harris | Jeff Russell | Steve Carlton | Dale Mohorcic | 420 | 571 | -151 |
| 1987-07-25 | vs TEX | 97 | L 3-7 | 34-63 | 7 | 15,170 | Phil Niekro | Charlie Hough | Charlie Hough | Phil Niekro | Dale Mohorcic | 423 | 578 | -155 |
| 1987-07-26 | vs TEX | 98 | L 3-11 | 34-64 | 7 | 25,460 | Scott Bailes | Paul Kilgus | Paul Kilgus | Scott Bailes | | 426 | 589 | -163 |
| 1987-07-28 | vs BAL | 99 | W 4-3 | 35-64 | 7 | 12,250 | Darrel Akerfelds | Scott McGregor | Sammy Stewart | Tom Niedenfuer | | 430 | 592 | -162 |
| 1987-07-29 | vs BAL | 100 | L 4-7 | 35-65 | 7 | 8,393 | Tom Candiotti | Eric Bell | Eric Bell | Tom Candiotti | | 434 | 599 | -165 |
| 1987-07-30 | vs BAL | 101 | W 6-4 | 36-65 | 7 | 7,865 | Steve Carlton | Mike Flanagan | Sammy Stewart | Mark Williamson | | 440 | 603 | -163 |
| 1987-07-31 | @ TOR | 102 | L 3-8 | 36-66 | 7 | 30,256 | Phil Niekro | Jimmy Key | Jimmy Key | Reggie Ritter | | 443 | 611 | -168 |
| 1987-08-01 | @ TOR | 103 | W 3-0 | 37-66 | 7 | 38,435 | Scott Bailes | Jim Clancy | Scott Bailes | Jim Clancy | Sammy Stewart | 446 | 611 | -165 |
| 1987-08-02 | @ TOR | 104 | L 5-11 | 37-67 | 7 | 33,351 | Darrel Akerfelds | Dave Stieb | Dave Stieb | Darrel Akerfelds | Gary Lavelle | 451 | 622 | -171 |
| 1987-08-03 | vs NYA | 105 | W 2-0 | 38-67 | 7 | 14,587 | Tom Candiotti | Steve Trout | Tom Candiotti | Steve Trout | | 453 | 622 | -169 |
| 1987-08-04 | vs NYA | 106 | W 15-3 | 39-67 | 7 | 15,283 | Ken Schrom | Tommy John | Ken Schrom | Tommy John | | 468 | 625 | -157 |
| 1987-08-05 | vs NYA | 107 | L 2-5 | 39-68 | 7 | 17,670 | Phil Niekro | Brad Arnsberg | Brad Arnsberg | Phil Niekro | Dave Righetti | 470 | 630 | -160 |
| 1987-08-06 | vs TOR | 108 | W 14-5 | 40-68 | 7 | 7,978 | Scott Bailes | Jim Clancy | Scott Bailes | Jim Clancy | | 484 | 635 | -151 |
| 1987-08-07 | vs TOR | 109 | L 1-15 | 40-69 | 7 | 24,049 | Darrel Akerfelds | Dave Stieb | Dave Stieb | Darrel Akerfelds | | 485 | 650 | -165 |
| 1987-08-08 | vs TOR | 110 | W 3-1 | 41-69 | 7 | 16,706 | Tom Candiotti | Jose Nunez | Tom Candiotti | Jose Nunez | | 488 | 651 | -163 |
| 1987-08-09 | vs TOR | 111 | L 1-5 | 41-70 | 7 | 13,890 | Ken Schrom | John Cerutti | John Cerutti | Ken Schrom | | 489 | 656 | -167 |
| 1987-08-10 | @ BAL | 112 | L 3-4 | 41-71 | 7 | 21,557 | Rich Yett | Mike Flanagan | Mark Williamson | Don Gordon | Tom Niedenfuer | 492 | 660 | -168 |
| 1987-08-11 | @ BAL | 113 | W 6-3 | 42-71 | 7 | 23,517 | Scott Bailes | Dave J. Schmidt | Scott Bailes | Dave J. Schmidt | Doug Jones | 498 | 663 | -165 |
| 1987-08-12 | @ BAL | 114 | W 8-6 | 43-71 | 7 | 19,566 | Darrel Akerfelds | Ken Dixon | Darrel Akerfelds | Mike Griffin | Doug Jones | 506 | 669 | -163 |
| 1987-08-14 | @ NYA | 115 | W 6-5 | 44-71 | 7 | 35,201 | Tom Candiotti | Tommy John | Tom Candiotti | Brad Arnsberg | Doug Jones | 512 | 674 | -162 |
| 1987-08-15 | @ NYA | 116 | L 2-11 | 44-72 | 7 | 38,930 | Ken Schrom | Dennis Rasmussen | Dennis Rasmussen | Ken Schrom | Tim Stoddard | 514 | 685 | -171 |
| 1987-08-16 | @ NYA | 117 | W 1-0 | 45-72 | 7 | 38,807 | Rich Yett | Ron Guidry | Rich Yett | Ron Guidry | Doug Jones | 515 | 685 | -170 |
| 1987-08-17 | vs MIL | 118 | L 3-5 | 45-73 | 7 | 7,011 | Scott Bailes | Mark Knudson | Mark Knudson | Scott Bailes | | 518 | 690 | -172 |
| 1987-08-18 | vs MIL | 119 | W 9-8 | 46-73 | 7 | 10,205 | Darrel Akerfelds | Chris Bosio | John Farrell | Ray Burris | | 527 | 698 | -171 |
| 1987-08-19 | vs MIL | 120 | L 2-13 | 46-74 | 7 | 8,288 | Tom Candiotti | Juan Nieves | Juan Nieves | Tom Candiotti | | 529 | 711 | -182 |
| 1987-08-20 | vs MIL | 121 | L 2-14 | 46-75 | 7 | 7,855 | Ken Schrom | Teddy Higuera | Teddy Higuera | Ken Schrom | | 531 | 725 | -194 |
| 1987-08-21 | vs DET | 122 | W 12-4 | 48-75 | 7 | 0 | Rich Yett | Dan Petry | Jamie Easterly | Dan Petry | Don Gordon | 543 | 729 | -186 |
| 1987-08-21 | vs DET | 123 | W 8-3 | 48-75 | 7 | 20,965 | John Farrell | Frank Tanana | John Farrell | Frank Tanana | | 551 | 732 | -181 |
| 1987-08-22 | vs DET | 124 | L 6-8 | 48-76 | 7 | 20,148 | Scott Bailes | Jeff Robinson | Mike Henneman | Scott Bailes | Eric King | 557 | 740 | -183 |
| 1987-08-23 | vs DET | 125 | L 3-4 | 48-77 | 7 | 21,097 | Tom Candiotti | Jack Morris | Jack Morris | Tom Candiotti | | 560 | 744 | -184 |
| 1987-08-25 | @ MIL | 126 | L 9-10 | 48-78 | 7 | 15,580 | Ken Schrom | Juan Nieves | Juan Nieves | Ken Schrom | Chuck Crim | 569 | 754 | -185 |
| 1987-08-26 | @ MIL | 127 | L 0-1 | 48-79 | 7 | 11,246 | John Farrell | Teddy Higuera | Teddy Higuera | Doug Jones | | 569 | 755 | -186 |
| 1987-08-27 | @ MIL | 128 | L 3-4 | 48-80 | 7 | 15,175 | Darrel Akerfelds | Bill Wegman | Mark Knudson | Darrel Akerfelds | Chuck Crim | 572 | 759 | -187 |
| 1987-08-29 | vs BOS | 129 | W 7-2 | 50-80 | 7 | 0 | Tom Candiotti | Bob Stanley | Tom Candiotti | Bob Stanley | | 579 | 761 | -182 |
| 1987-08-29 | vs BOS | 130 | W 2-1 | 50-80 | 7 | 16,204 | Rich Yett | Bruce Hurst | Rich Yett | Bruce Hurst | | 581 | 762 | -181 |
| 1987-08-30 | vs BOS | 131 | L 3-7 | 50-81 | 7 | 17,189 | Scott Bailes | Roger Clemens | Roger Clemens | Scott Bailes | Wes Gardner | 584 | 769 | -185 |
| 1987-08-31 | @ DET | 132 | W 7-2 | 51-81 | 7 | 22,530 | John Farrell | Frank Tanana | John Farrell | Frank Tanana | | 591 | 771 | -180 |
| 1987-09-01 | @ DET | 133 | L 5-6 | 51-82 | 7 | 19,810 | Darrel Akerfelds | Jeff Robinson | Guillermo Hernandez | Don Gordon | | 596 | 777 | -181 |
| 1987-09-02 | @ DET | 134 | L 1-2 | 51-83 | 7 | 20,516 | Tom Candiotti | Jack Morris | Jack Morris | Tom Candiotti | | 597 | 779 | -182 |
| 1987-09-03 | @ DET | 135 | L 1-3 | 51-84 | 7 | 21,964 | Rich Yett | Walt Terrell | Walt Terrell | Rich Yett | | 598 | 782 | -184 |
| 1987-09-04 | @ BOS | 136 | L 2-5 | 51-85 | 7 | 23,378 | Scott Bailes | Roger Clemens | Roger Clemens | Scott Bailes | Wes Gardner | 600 | 787 | -187 |
| 1987-09-05 | @ BOS | 137 | W 15-2 | 52-85 | 7 | 28,638 | John Farrell | Bob Stanley | John Farrell | Bob Stanley | | 615 | 789 | -174 |
| 1987-09-06 | @ BOS | 138 | W 3-1 | 53-85 | 7 | 25,520 | Darrel Akerfelds | Jeff Sellers | Darrel Akerfelds | Jeff Sellers | Doug Jones | 618 | 790 | -172 |
| 1987-09-07 | vs SEA | 139 | L 4-6 | 53-86 | 7 | 10,147 | Tom Candiotti | Mark Langston | Mark Langston | Tom Candiotti | Jerry Reed | 622 | 796 | -174 |
| 1987-09-08 | vs SEA | 140 | L 0-7 | 53-87 | 7 | 4,517 | Rich Yett | Mike Morgan | Mike Morgan | Rich Yett | | 622 | 803 | -181 |
| 1987-09-09 | vs SEA | 141 | L 4-9 | 53-88 | 7 | 4,849 | Ken Schrom | Mike Moore | Mike Moore | Jamie Easterly | | 626 | 812 | -186 |
| 1987-09-11 | vs MIN | 142 | L 10-13 | 53-89 | 7 | 7,964 | John Farrell | Mike Smithson | Jeff Reardon | Don Gordon | Juan Berenguer | 636 | 825 | -189 |
| 1987-09-12 | vs MIN | 143 | W 5-4 | 54-89 | 7 | 9,156 | Darrel Akerfelds | Les Straker | Doug Jones | Juan Berenguer | | 641 | 829 | -188 |
| 1987-09-13 | vs MIN | 144 | L 3-7 | 54-90 | 7 | 7,474 | Tom Candiotti | Bert Blyleven | Jeff Reardon | Tom Candiotti | | 644 | 836 | -192 |
| 1987-09-14 | @ SEA | 145 | W 11-8 | 55-90 | 7 | 7,839 | Rich Yett | Mike Morgan | Scott Bailes | Mike Morgan | Doug Jones | 655 | 844 | -189 |
| 1987-09-15 | @ SEA | 146 | W 4-2 | 56-90 | 7 | 8,017 | Ken Schrom | Mike Moore | Ken Schrom | Mike Moore | | 659 | 846 | -187 |
| 1987-09-16 | @ SEA | 147 | L 3-5 | 56-91 | 7 | 6,851 | John Farrell | Mike Campbell | Bill Wilkinson | Sammy Stewart | | 662 | 851 | -189 |
| 1987-09-18 | @ MIN | 148 | L 4-9 | 56-92 | 7 | 23,173 | Darrel Akerfelds | Bert Blyleven | Bert Blyleven | Darrel Akerfelds | | 666 | 860 | -194 |
| 1987-09-19 | @ MIN | 149 | L 1-3 | 56-93 | 7 | 23,581 | Tom Candiotti | Frank Viola | Frank Viola | Tom Candiotti | Jeff Reardon | 667 | 863 | -196 |
| 1987-09-20 | @ MIN | 150 | L 2-3 | 56-94 | 7 | 18,906 | Rich Yett | Les Straker | Les Straker | Rich Yett | Jeff Reardon | 669 | 866 | -197 |
| 1987-09-21 | vs OAK | 151 | W 6-3 | 57-94 | 7 | 4,532 | Ken Schrom | Dave Stewart | Doug Jones | Dave Stewart | | 675 | 869 | -194 |
| 1987-09-22 | vs OAK | 152 | L 2-10 | 57-95 | 7 | 4,682 | John Farrell | Rick Honeycutt | Rick Honeycutt | John Farrell | Gene Nelson | 677 | 879 | -202 |
| 1987-09-23 | vs OAK | 153 | W 8-6 | 58-95 | 7 | 4,879 | Darrel Akerfelds | Steve Ontiveros | Ed Vande Berg | Eric Plunk | Sammy Stewart | 685 | 885 | -200 |
| 1987-09-25 | vs CAL | 154 | W 7-5 | 59-95 | 7 | 10,453 | Tom Candiotti | Don Sutton | Doug Jones | Gary Lucas | | 692 | 890 | -198 |
| 1987-09-26 | vs CAL | 155 | W 11-10 | 60-95 | 7 | 9,320 | Rich Yett | Willie Fraser | Reggie Ritter | Gary Lucas | | 703 | 900 | -197 |
| 1987-09-27 | vs CAL | 156 | L 8-11 | 60-96 | 7 | 13,979 | Ken Schrom | Chuck Finley | Don Sutton | Ken Schrom | | 711 | 911 | -200 |
| 1987-09-29 | @ OAK | 157 | L 4-5 | 60-97 | 7 | 7,291 | John Farrell | Steve Ontiveros | Steve Ontiveros | Doug Jones | Dennis Eckersley | 715 | 916 | -201 |
| 1987-09-30 | @ OAK | 158 | L 3-4 | 60-98 | 7 | 9,428 | Darrel Akerfelds | Dave Stewart | Dave Stewart | Darrel Akerfelds | Eric Plunk | 718 | 920 | -202 |
| 1987-10-01 | @ OAK | 159 | L 5-9 | 60-99 | 7 | 9,846 | Tom Candiotti | Storm Davis | Greg Cadaret | Tom Candiotti | Dennis Eckersley | 723 | 929 | -206 |
| 1987-10-02 | @ CAL | 160 | L 4-10 | 60-100 | 7 | 25,030 | Rich Yett | Don Sutton | Don Sutton | Rich Yett | | 727 | 939 | -212 |
| 1987-10-03 | @ CAL | 161 | L 5-12 | 60-101 | 7 | 22,750 | Ken Schrom | Jack Lazorko | Jack Lazorko | Ken Schrom | | 732 | 951 | -219 |
| 1987-10-04 | @ CAL | 162 | W 10-6 | 61-101 | 7 | 36,779 | John Farrell | Mike Witt | John Farrell | Mike Witt | Doug Jones | 742 | 957 | -215 |