| 1987-04-06 | @ MIL | 1 | L 1-5 | 0-1 | 5 | 52,585 | Bob Stanley | Teddy Higuera | Teddy Higuera | Bob Stanley | | 1 | 5 | -4 |
| 1987-04-08 | @ MIL | 2 | L 2-3 | 0-2 | 5 | 7,412 | Al Nipper | Bill Wegman | Chuck Crim | Wes Gardner | Dan Plesac | 3 | 8 | -5 |
| 1987-04-09 | @ MIL | 3 | L 11-12 | 0-3 | 7 | 9,628 | Jeff Sellers | Mike Birkbeck | Chris Bosio | Steve Crawford | Mark Clear | 14 | 20 | -6 |
| 1987-04-10 | vs TOR | 4 | W 3-0 | 1-3 | 6 | 33,679 | Bruce Hurst | Dave Stieb | Bruce Hurst | Dave Stieb | | 17 | 20 | -3 |
| 1987-04-11 | vs TOR | 5 | L 1-11 | 1-4 | 6 | 33,365 | Roger Clemens | Jimmy Key | Jimmy Key | Roger Clemens | | 18 | 31 | -13 |
| 1987-04-12 | vs TOR | 6 | W 8-3 | 2-4 | 6 | 27,521 | Bob Stanley | Jim Clancy | Bob Stanley | Jim Clancy | | 26 | 34 | -8 |
| 1987-04-14 | vs TEX | 7 | W 4-1 | 3-4 | 6 | 13,740 | Al Nipper | Ed Correa | Al Nipper | Ed Correa | Calvin Schiraldi | 30 | 35 | -5 |
| 1987-04-15 | vs TEX | 8 | W 5-4 | 4-4 | 4 | 16,870 | Bruce Hurst | Charlie Hough | Bruce Hurst | Dale Mohorcic | Wes Gardner | 35 | 39 | -4 |
| 1987-04-16 | @ TOR | 9 | L 2-4 | 4-5 | 6 | 22,065 | Roger Clemens | Jimmy Key | Jimmy Key | Roger Clemens | Tom Henke | 37 | 43 | -6 |
| 1987-04-17 | @ TOR | 10 | L 5-10 | 4-6 | 6 | 36,400 | Bob Stanley | Duane Ward | John Cerutti | Bob Stanley | Mark Eichhorn | 42 | 53 | -11 |
| 1987-04-18 | @ TOR | 11 | W 6-4 | 5-6 | 6 | 39,107 | Jeff Sellers | Jim Clancy | Jeff Sellers | Jim Clancy | Calvin Schiraldi | 48 | 57 | -9 |
| 1987-04-19 | @ TOR | 12 | W 4-1 | 6-6 | 5 | 28,140 | Al Nipper | Joe Johnson | Al Nipper | Joe Johnson | Wes Gardner | 52 | 58 | -6 |
| 1987-04-20 | vs KCA | 13 | L 2-10 | 6-7 | 6 | 35,486 | Bruce Hurst | Bret Saberhagen | Bret Saberhagen | Bruce Hurst | | 54 | 68 | -14 |
| 1987-04-21 | vs KCA | 14 | W 8-0 | 7-7 | 4 | 29,082 | Roger Clemens | Rick Anderson | Roger Clemens | Rick Anderson | | 62 | 68 | -6 |
| 1987-04-22 | vs KCA | 15 | W 1-0 | 8-7 | 4 | 24,589 | Bob Stanley | Danny Jackson | Bob Stanley | Danny Jackson | | 63 | 68 | -5 |
| 1987-04-24 | @ TEX | 16 | L 4-6 | 8-8 | 4 | 26,982 | Al Nipper | Bobby Witt | Greg Harris | Calvin Schiraldi | | 67 | 74 | -7 |
| 1987-04-25 | @ TEX | 17 | L 1-2 | 8-9 | 4 | 34,643 | Bruce Hurst | Jose Guzman | Jose Guzman | Bruce Hurst | | 68 | 76 | -8 |
| 1987-04-26 | @ TEX | 18 | L 3-5 | 8-10 | 4 | 24,470 | Roger Clemens | Charlie Hough | Mitch Williams | Calvin Schiraldi | | 71 | 81 | -10 |
| 1987-04-27 | @ OAK | 19 | L 2-5 | 8-11 | 5 | 25,109 | Bob Stanley | Curt Young | Curt Young | Bob Stanley | | 73 | 86 | -13 |
| 1987-04-28 | @ OAK | 20 | L 1-7 | 8-12 | 5 | 14,148 | Jeff Sellers | Joaquin Andujar | Dennis Eckersley | Jeff Sellers | | 74 | 93 | -19 |
| 1987-04-29 | @ SEA | 21 | W 11-5 | 9-12 | 5 | 10,378 | Al Nipper | Mike Moore | Al Nipper | Mike Moore | | 85 | 98 | -13 |
| 1987-04-30 | @ SEA | 22 | L 2-11 | 9-13 | 6 | 9,985 | Bruce Hurst | Scott Bankhead | Scott Bankhead | Bruce Hurst | | 87 | 109 | -22 |
| 1987-05-01 | @ CAL | 23 | W 12-3 | 10-13 | 4 | 50,352 | Roger Clemens | Urbano Lugo | Roger Clemens | Urbano Lugo | | 99 | 112 | -13 |
| 1987-05-02 | @ CAL | 24 | L 2-4 | 10-14 | 4 | 43,726 | Bob Stanley | Mike Witt | Mike Witt | Bob Stanley | | 101 | 116 | -15 |
| 1987-05-03 | @ CAL | 25 | L 4-11 | 10-15 | 4 | 40,018 | Al Nipper | John Candelaria | John Candelaria | Al Nipper | | 105 | 127 | -22 |
| 1987-05-05 | vs OAK | 26 | W 6-0 | 11-15 | 4 | 16,444 | Bruce Hurst | Dave Stewart | Bruce Hurst | Dave Stewart | | 111 | 127 | -16 |
| 1987-05-06 | vs OAK | 27 | W 6-2 | 12-15 | 4 | 19,154 | Roger Clemens | Dennis Eckersley | Calvin Schiraldi | Dennis Eckersley | | 117 | 129 | -12 |
| 1987-05-08 | vs CAL | 28 | W 6-4 | 13-15 | 4 | 32,072 | Bob Stanley | John Candelaria | Joe Sambito | DeWayne Buice | | 123 | 133 | -10 |
| 1987-05-09 | vs CAL | 29 | L 1-8 | 13-16 | 5 | 34,205 | Al Nipper | Willie Fraser | Willie Fraser | Al Nipper | | 124 | 141 | -17 |
| 1987-05-10 | vs CAL | 30 | W 7-0 | 14-16 | 5 | 32,121 | Bruce Hurst | Don Sutton | Bruce Hurst | Don Sutton | | 131 | 141 | -10 |
| 1987-05-11 | vs SEA | 31 | L 3-4 | 14-17 | 5 | 21,410 | Roger Clemens | Scott Bankhead | Scott Bankhead | Roger Clemens | Ed Nunez | 134 | 145 | -11 |
| 1987-05-12 | vs SEA | 32 | W 3-2 | 15-17 | 5 | 19,193 | Jeff Sellers | Mike Trujillo | Jeff Sellers | Mike Trujillo | Wes Gardner | 137 | 147 | -10 |
| 1987-05-13 | vs SEA | 33 | L 4-5 | 15-18 | 5 | 20,270 | Al Nipper | Mark Langston | Mark Langston | Joe Sambito | Steve Shields | 141 | 152 | -11 |
| 1987-05-15 | @ MIN | 34 | L 1-3 | 15-19 | 5 | 13,878 | Bruce Hurst | Juan Berenguer | George Frazier | Bruce Hurst | | 142 | 155 | -13 |
| 1987-05-16 | @ MIN | 35 | W 6-1 | 16-19 | 5 | 23,414 | Roger Clemens | Bert Blyleven | Roger Clemens | Bert Blyleven | | 148 | 156 | -8 |
| 1987-05-17 | @ MIN | 36 | L 8-10 | 16-20 | 6 | 20,716 | Jeff Sellers | Frank Viola | Keith Atherton | Calvin Schiraldi | | 156 | 166 | -10 |
| 1987-05-18 | @ KCA | 37 | L 2-4 | 16-21 | 6 | 34,110 | Al Nipper | Mark Gubicza | Mark Gubicza | Al Nipper | Dan Quisenberry | 158 | 170 | -12 |
| 1987-05-19 | @ KCA | 38 | L 1-4 | 16-22 | 6 | 25,340 | Bob Stanley | Bret Saberhagen | Bret Saberhagen | Bob Stanley | | 159 | 174 | -15 |
| 1987-05-20 | @ KCA | 39 | W 7-1 | 17-22 | 6 | 24,168 | Bruce Hurst | Danny Jackson | Bruce Hurst | Danny Jackson | | 166 | 175 | -9 |
| 1987-05-22 | vs CHA | 40 | L 3-4 | 17-23 | 6 | 31,894 | Roger Clemens | Richard Dotson | Jim Winn | Roger Clemens | Bob James | 169 | 179 | -10 |
| 1987-05-23 | vs CHA | 41 | L 1-9 | 17-24 | 6 | 31,263 | Al Nipper | Floyd Bannister | Floyd Bannister | Al Nipper | | 170 | 188 | -18 |
| 1987-05-24 | vs CHA | 42 | L 1-4 | 17-25 | 6 | 31,369 | Bob Stanley | Jose DeLeon | Ray Searage | Bob Stanley | Bob James | 171 | 192 | -21 |
| 1987-05-25 | vs CLE | 43 | W 10-6 | 18-25 | 6 | 19,858 | Bruce Hurst | Tom Candiotti | Steve Crawford | Mark Huismann | | 181 | 198 | -17 |
| 1987-05-26 | vs CLE | 44 | W 6-5 | 19-25 | 6 | 18,493 | Al Nipper | Greg Swindell | Al Nipper | Greg Swindell | | 187 | 203 | -16 |
| 1987-05-27 | vs CLE | 45 | W 1-0 | 20-25 | 6 | 22,906 | Roger Clemens | Phil Niekro | Roger Clemens | Phil Niekro | | 188 | 203 | -15 |
| 1987-05-28 | vs CLE | 46 | W 12-8 | 21-25 | 6 | 22,305 | John Leister | Steve Carlton | Steve Crawford | Rich Yett | Wes Gardner | 200 | 211 | -11 |
| 1987-05-29 | @ CHA | 47 | L 6-8 | 21-26 | 6 | 18,805 | Bob Stanley | Floyd Bannister | Jim Winn | Bob Stanley | Bob James | 206 | 219 | -13 |
| 1987-05-30 | @ CHA | 48 | L 2-3 | 21-27 | 6 | 19,053 | Bruce Hurst | Jose DeLeon | Bob James | Wes Gardner | | 208 | 222 | -14 |
| 1987-05-31 | @ CHA | 49 | W 10-9 | 22-27 | 6 | 21,138 | Al Nipper | Joel Davis | Calvin Schiraldi | Ray Searage | | 218 | 231 | -13 |
| 1987-06-01 | vs MIN | 50 | L 5-9 | 22-28 | 6 | 20,221 | Roger Clemens | Frank Viola | Frank Viola | Roger Clemens | | 223 | 240 | -17 |
| 1987-06-02 | vs MIN | 51 | W 6-5 | 23-28 | 6 | 16,910 | John Leister | Juan Berenguer | Calvin Schiraldi | Jeff Reardon | | 229 | 245 | -16 |
| 1987-06-03 | vs MIN | 52 | W 7-6 | 24-28 | 6 | 20,638 | Bob Stanley | Les Straker | Calvin Schiraldi | Joe Klink | | 236 | 251 | -15 |
| 1987-06-04 | vs DET | 53 | W 8-5 | 25-28 | 6 | 24,660 | Bruce Hurst | Walt Terrell | Bruce Hurst | Walt Terrell | | 244 | 256 | -12 |
| 1987-06-05 | vs DET | 54 | L 2-4 | 25-29 | 6 | 33,827 | Al Nipper | Jeff Robinson | Jeff Robinson | Al Nipper | Eric King | 246 | 260 | -14 |
| 1987-06-06 | vs DET | 55 | L 3-5 | 25-30 | 6 | 33,902 | Roger Clemens | Frank Tanana | Eric King | Wes Gardner | | 249 | 265 | -16 |
| 1987-06-07 | vs DET | 56 | L 8-18 | 25-31 | 6 | 33,254 | John Leister | Dan Petry | Mike Henneman | John Leister | | 257 | 283 | -26 |
| 1987-06-08 | @ BAL | 57 | W 6-2 | 26-31 | 6 | 32,039 | Bob Stanley | Jeff Ballard | Bob Stanley | Jeff Ballard | | 263 | 285 | -22 |
| 1987-06-09 | @ BAL | 58 | W 2-1 | 27-31 | 6 | 17,548 | Bruce Hurst | Dave J. Schmidt | Bruce Hurst | Ken Dixon | | 265 | 286 | -21 |
| 1987-06-10 | @ BAL | 59 | W 15-4 | 28-31 | 5 | 21,748 | Al Nipper | Eric Bell | Al Nipper | Eric Bell | | 280 | 290 | -10 |
| 1987-06-12 | @ DET | 60 | L 4-11 | 28-32 | 5 | 32,341 | Roger Clemens | Frank Tanana | Frank Tanana | Roger Clemens | | 284 | 301 | -17 |
| 1987-06-13 | @ DET | 61 | L 4-6 | 28-33 | 5 | 40,427 | Bob Stanley | Dan Petry | Dan Petry | Steve Crawford | Guillermo Hernandez | 288 | 307 | -19 |
| 1987-06-14 | @ DET | 62 | L 1-2 | 28-34 | 6 | 28,203 | Bruce Hurst | Jack Morris | Jack Morris | Bruce Hurst | | 289 | 309 | -20 |
| 1987-06-16 | @ CLE | 63 | L 7-8 | 28-35 | 5 | 17,949 | Al Nipper | Ken Schrom | Mark Huismann | Al Nipper | Mike Armstrong | 296 | 317 | -21 |
| 1987-06-17 | @ CLE | 64 | W 4-0 | 29-35 | 5 | 12,910 | Roger Clemens | Tom Candiotti | Roger Clemens | Tom Candiotti | | 300 | 317 | -17 |
| 1987-06-18 | @ CLE | 65 | L 5-7 | 29-36 | 5 | 11,000 | Bob Stanley | Rich Yett | Mike Armstrong | Bob Stanley | Mark Huismann | 305 | 324 | -19 |
| 1987-06-19 | vs NYA | 66 | L 5-10 | 29-37 | 5 | 33,835 | Bruce Hurst | Ron Guidry | Charles Hudson | Joe Sambito | | 310 | 334 | -24 |
| 1987-06-20 | vs NYA | 67 | W 9-4 | 30-37 | 5 | 33,134 | Al Nipper | Tommy John | Al Nipper | Tommy John | | 319 | 338 | -19 |
| 1987-06-21 | vs NYA | 68 | W 4-2 | 31-37 | 5 | 33,012 | Roger Clemens | Bob Tewksbury | Roger Clemens | Bob Tewksbury | | 323 | 340 | -17 |
| 1987-06-22 | vs MIL | 69 | W 5-2 | 32-37 | 5 | 29,546 | Oil Can Boyd | John Henry Johnson | Oil Can Boyd | John Henry Johnson | | 328 | 342 | -14 |
| 1987-06-23 | vs MIL | 70 | W 9-5 | 33-37 | 5 | 31,104 | Jeff Sellers | Juan Nieves | Steve Crawford | Bill Wegman | Calvin Schiraldi | 337 | 347 | -10 |
| 1987-06-24 | vs MIL | 71 | W 8-7 | 34-37 | 5 | 34,376 | Bruce Hurst | Teddy Higuera | Bruce Hurst | Teddy Higuera | Calvin Schiraldi | 345 | 354 | -9 |
| 1987-06-26 | @ NYA | 72 | L 11-12 | 34-38 | 5 | 45,123 | Roger Clemens | Tommy John | Tim Stoddard | Calvin Schiraldi | | 356 | 366 | -10 |
| 1987-06-27 | @ NYA | 73 | L 1-9 | 34-39 | 5 | 47,829 | Oil Can Boyd | Bob Tewksbury | Bob Tewksbury | Oil Can Boyd | | 357 | 375 | -18 |
| 1987-06-28 | @ NYA | 74 | W 6-2 | 35-39 | 5 | 54,172 | Al Nipper | Rick Rhoden | Al Nipper | Rick Rhoden | | 363 | 377 | -14 |
| 1987-06-29 | vs BAL | 75 | W 14-3 | 36-39 | 5 | 31,139 | Bruce Hurst | Dave J. Schmidt | Bruce Hurst | Dave J. Schmidt | | 377 | 380 | -3 |
| 1987-06-30 | vs BAL | 76 | W 13-9 | 37-39 | 5 | 29,433 | Jeff Sellers | Mark Williamson | Steve Crawford | Mark Williamson | Calvin Schiraldi | 390 | 389 | 1 |
| 1987-07-01 | vs BAL | 77 | W 6-2 | 38-39 | 5 | 33,075 | Roger Clemens | Mike Griffin | Roger Clemens | Mike Griffin | | 396 | 391 | 5 |
| 1987-07-02 | @ OAK | 78 | L 3-5 | 38-40 | 5 | 16,134 | Al Nipper | Joaquin Andujar | Joaquin Andujar | Al Nipper | | 399 | 396 | 3 |
| 1987-07-03 | @ OAK | 79 | W 2-0 | 39-40 | 5 | 43,050 | Jeff Sellers | Steve Ontiveros | Jeff Sellers | Steve Ontiveros | | 401 | 396 | 5 |
| 1987-07-04 | @ OAK | 80 | L 5-9 | 39-41 | 5 | 24,298 | Bruce Hurst | Jose Rijo | Jose Rijo | Bruce Hurst | Dennis Eckersley | 406 | 405 | 1 |
| 1987-07-05 | @ OAK | 81 | L 3-6 | 39-42 | 5 | 32,655 | Oil Can Boyd | Dave Stewart | Dave Stewart | Oil Can Boyd | Dennis Eckersley | 409 | 411 | -2 |
| 1987-07-06 | @ CAL | 82 | L 7-10 | 39-43 | 5 | 28,953 | Roger Clemens | Jerry Reuss | Greg Minton | Wes Gardner | | 416 | 421 | -5 |
| 1987-07-07 | @ CAL | 83 | L 4-9 | 39-44 | 5 | 31,526 | Al Nipper | Mike Witt | Mike Witt | Al Nipper | DeWayne Buice | 420 | 430 | -10 |
| 1987-07-08 | @ CAL | 84 | L 3-5 | 39-45 | 5 | 32,576 | Jeff Sellers | Willie Fraser | Willie Fraser | Jeff Sellers | DeWayne Buice | 423 | 435 | -12 |
| 1987-07-09 | @ SEA | 85 | L 5-11 | 39-46 | 5 | 12,344 | Bruce Hurst | Mike Campbell | Roy Thomas | Wes Gardner | | 428 | 446 | -18 |
| 1987-07-10 | @ SEA | 86 | W 7-4 | 40-46 | 5 | 23,935 | Oil Can Boyd | Mark Langston | Calvin Schiraldi | Mark Langston | | 435 | 450 | -15 |
| 1987-07-11 | @ SEA | 87 | W 10-4 | 41-46 | 5 | 33,315 | Roger Clemens | Mike Morgan | Roger Clemens | Mike Morgan | | 445 | 454 | -9 |
| 1987-07-12 | @ SEA | 88 | L 1-6 | 41-47 | 5 | 13,391 | Al Nipper | Lee Guetterman | Lee Guetterman | Al Nipper | Jerry Reed | 446 | 460 | -14 |
| 1987-07-16 | vs OAK | 89 | L 3-6 | 41-48 | 5 | 34,861 | Roger Clemens | Dave Stewart | Dave Stewart | Roger Clemens | Dennis Eckersley | 449 | 466 | -17 |
| 1987-07-17 | vs OAK | 90 | L 6-11 | 41-49 | 5 | 34,543 | Oil Can Boyd | Joaquin Andujar | Greg Cadaret | Bob Stanley | | 455 | 477 | -22 |
| 1987-07-18 | vs OAK | 91 | W 5-3 | 42-49 | 5 | 34,720 | Bruce Hurst | Jose Rijo | Bruce Hurst | Dennis Eckersley | | 460 | 480 | -20 |
| 1987-07-19 | vs OAK | 92 | L 3-5 | 42-50 | 5 | 34,114 | Al Nipper | Steve Ontiveros | Jay Howell | Bob Stanley | Bill Caudill | 463 | 485 | -22 |
| 1987-07-20 | vs CAL | 93 | L 2-3 | 42-51 | 5 | 27,322 | Jeff Sellers | Willie Fraser | Greg Minton | Jeff Sellers | DeWayne Buice | 465 | 488 | -23 |
| 1987-07-21 | vs CAL | 94 | W 3-0 | 43-51 | 5 | 30,301 | Roger Clemens | Kirk McCaskill | Roger Clemens | Kirk McCaskill | | 468 | 488 | -20 |
| 1987-07-22 | vs CAL | 95 | L 5-6 | 43-52 | 5 | 31,729 | Oil Can Boyd | Mike Witt | Mike Witt | Oil Can Boyd | Greg Minton | 473 | 494 | -21 |
| 1987-07-24 | vs SEA | 96 | W 5-4 | 44-52 | 5 | 29,999 | Bruce Hurst | Lee Guetterman | Bruce Hurst | Lee Guetterman | | 478 | 498 | -20 |
| 1987-07-25 | vs SEA | 97 | W 11-5 | 45-52 | 5 | 32,040 | Oil Can Boyd | Scott Bankhead | Tom Bolton | Stan Clarke | | 489 | 503 | -14 |
| 1987-07-26 | vs SEA | 98 | W 11-1 | 46-52 | 5 | 31,974 | Roger Clemens | Mike Moore | Roger Clemens | Mike Moore | | 500 | 504 | -4 |
| 1987-07-27 | @ TOR | 99 | L 8-10 | 46-53 | 5 | 35,425 | Jeff Sellers | Jim Clancy | Jeff Musselman | Calvin Schiraldi | Tom Henke | 508 | 514 | -6 |
| 1987-07-28 | @ TOR | 100 | L 4-5 | 46-54 | 5 | 36,122 | Wes Gardner | Dave Stieb | Jeff Musselman | Joe Sambito | Tom Henke | 512 | 519 | -7 |
| 1987-07-29 | @ TOR | 101 | W 6-5 | 47-54 | 5 | 35,052 | Bruce Hurst | Jose Nunez | Calvin Schiraldi | Gary Lavelle | | 518 | 524 | -6 |
| 1987-07-31 | @ KCA | 102 | W 4-0 | 48-54 | 5 | 40,149 | Roger Clemens | Bret Saberhagen | Roger Clemens | Bret Saberhagen | | 522 | 524 | -2 |
| 1987-08-01 | @ KCA | 103 | L 0-4 | 48-55 | 5 | 40,111 | Jeff Sellers | Charlie Leibrandt | Charlie Leibrandt | Jeff Sellers | | 522 | 528 | -6 |
| 1987-08-02 | @ KCA | 104 | L 5-13 | 48-56 | 5 | 29,154 | Bob Stanley | Mark Gubicza | Mark Gubicza | Bob Stanley | | 527 | 541 | -14 |
| 1987-08-03 | @ TEX | 105 | W 11-2 | 49-56 | 5 | 21,928 | Bruce Hurst | Jose Guzman | Bruce Hurst | Jose Guzman | | 538 | 543 | -5 |
| 1987-08-04 | @ TEX | 106 | W 8-6 | 50-56 | 5 | 17,377 | Rob Woodward | Greg Harris | Calvin Schiraldi | Dale Mohorcic | | 546 | 549 | -3 |
| 1987-08-05 | @ TEX | 107 | L 8-9 | 50-57 | 5 | 19,843 | Roger Clemens | Charlie Hough | Jose Guzman | Joe Sambito | | 554 | 558 | -4 |
| 1987-08-07 | vs KCA | 108 | W 4-3 | 51-57 | 5 | 34,946 | Jeff Sellers | Charlie Leibrandt | Jeff Sellers | Charlie Leibrandt | | 558 | 561 | -3 |
| 1987-08-08 | vs KCA | 109 | W 8-3 | 52-57 | 5 | 34,622 | Bruce Hurst | Mark Gubicza | Bruce Hurst | Mark Gubicza | | 566 | 564 | 2 |
| 1987-08-09 | vs KCA | 110 | L 3-8 | 52-58 | 5 | 34,009 | Rob Woodward | Buddy Black | John Davis | Steve Crawford | | 569 | 572 | -3 |
| 1987-08-10 | vs TOR | 111 | W 9-1 | 53-58 | 5 | 30,606 | Roger Clemens | Jim Clancy | Roger Clemens | Jim Clancy | | 578 | 573 | 5 |
| 1987-08-11 | vs TOR | 112 | L 3-8 | 53-59 | 5 | 32,555 | Bob Stanley | Jimmy Key | Jimmy Key | Bob Stanley | | 581 | 581 | 0 |
| 1987-08-12 | vs TOR | 113 | L 4-10 | 53-60 | 5 | 33,403 | Jeff Sellers | Dave Stieb | Dave Stieb | Jeff Sellers | | 585 | 591 | -6 |
| 1987-08-14 | vs TEX | 114 | W 9-3 | 54-61 | 5 | 0 | Bruce Hurst | Bobby Witt | Bruce Hurst | Steve Howe | | 594 | 594 | 0 |
| 1987-08-14 | vs TEX | 115 | L 4-9 | 54-61 | 5 | 33,840 | Al Nipper | Charlie Hough | Charlie Hough | Al Nipper | | 598 | 603 | -5 |
| 1987-08-15 | vs TEX | 116 | W 7-6 | 55-61 | 5 | 31,189 | Roger Clemens | Jose Guzman | Wes Gardner | Steve Howe | | 605 | 609 | -4 |
| 1987-08-16 | vs TEX | 117 | W 12-2 | 56-61 | 5 | 31,438 | Bob Stanley | Greg Harris | Bob Stanley | Greg Harris | | 617 | 611 | 6 |
| 1987-08-17 | @ CHA | 118 | L 1-2 | 56-62 | 5 | 16,362 | Jeff Sellers | Dave LaPoint | Dave LaPoint | Jeff Sellers | Bobby Thigpen | 618 | 613 | 5 |
| 1987-08-18 | @ CHA | 119 | W 14-8 | 57-62 | 5 | 13,064 | Al Nipper | Floyd Bannister | Al Nipper | Floyd Bannister | | 632 | 621 | 11 |
| 1987-08-19 | @ CHA | 120 | L 3-8 | 57-63 | 5 | 14,275 | Bruce Hurst | Jose DeLeon | Jose DeLeon | Bruce Hurst | Bobby Thigpen | 635 | 629 | 6 |
| 1987-08-21 | vs MIN | 121 | W 11-3 | 58-63 | 5 | 33,490 | Roger Clemens | Frank Viola | Roger Clemens | Frank Viola | Wes Gardner | 646 | 632 | 14 |
| 1987-08-22 | vs MIN | 122 | W 6-5 | 59-63 | 5 | 29,794 | Bob Stanley | Les Straker | Calvin Schiraldi | Les Straker | | 652 | 637 | 15 |
| 1987-08-23 | vs MIN | 123 | W 6-4 | 60-63 | 5 | 32,956 | Jeff Sellers | Steve Carlton | Jeff Sellers | Steve Carlton | Wes Gardner | 658 | 641 | 17 |
| 1987-08-24 | vs CHA | 124 | L 3-6 | 60-64 | 5 | 25,136 | Bruce Hurst | Jose DeLeon | Jose DeLeon | Bruce Hurst | Scott Nielsen | 661 | 647 | 14 |
| 1987-08-25 | vs CHA | 125 | W 7-3 | 61-64 | 5 | 27,345 | Al Nipper | Richard Dotson | Steve Crawford | Richard Dotson | Wes Gardner | 668 | 650 | 18 |
| 1987-08-26 | vs CHA | 126 | L 3-5 | 61-65 | 5 | 29,947 | Roger Clemens | Bill Long | Bill Long | Roger Clemens | Scott Nielsen | 671 | 655 | 16 |
| 1987-08-29 | @ CLE | 127 | L 2-7 | 61-67 | 5 | 0 | Bob Stanley | Tom Candiotti | Tom Candiotti | Bob Stanley | | 673 | 662 | 11 |
| 1987-08-29 | @ CLE | 128 | L 1-2 | 61-67 | 5 | 16,204 | Bruce Hurst | Rich Yett | Rich Yett | Bruce Hurst | | 674 | 664 | 10 |
| 1987-08-30 | @ CLE | 129 | W 7-3 | 62-67 | 5 | 17,189 | Roger Clemens | Scott Bailes | Roger Clemens | Scott Bailes | Wes Gardner | 681 | 667 | 14 |
| 1987-09-01 | @ MIN | 130 | W 9-0 | 63-67 | 5 | 25,508 | Jeff Sellers | Joe Niekro | Jeff Sellers | Joe Niekro | | 690 | 667 | 23 |
| 1987-09-02 | @ MIN | 131 | L 4-5 | 63-68 | 5 | 19,565 | Al Nipper | Les Straker | Les Straker | Al Nipper | Jeff Reardon | 694 | 672 | 22 |
| 1987-09-03 | @ MIN | 132 | L 1-2 | 63-69 | 5 | 20,009 | Calvin Schiraldi | Bert Blyleven | Keith Atherton | Wes Gardner | | 695 | 674 | 21 |
| 1987-09-04 | vs CLE | 133 | W 5-2 | 64-69 | 5 | 23,378 | Roger Clemens | Scott Bailes | Roger Clemens | Scott Bailes | Wes Gardner | 700 | 676 | 24 |
| 1987-09-05 | vs CLE | 134 | L 2-15 | 64-70 | 5 | 28,638 | Bob Stanley | John Farrell | John Farrell | Bob Stanley | | 702 | 691 | 11 |
| 1987-09-06 | vs CLE | 135 | L 1-3 | 64-71 | 5 | 25,520 | Jeff Sellers | Darrel Akerfelds | Darrel Akerfelds | Jeff Sellers | Doug Jones | 703 | 694 | 9 |
| 1987-09-07 | vs NYA | 136 | L 5-9 | 64-72 | 5 | 32,544 | Bruce Hurst | Rick Rhoden | Rick Rhoden | Bruce Hurst | Tim Stoddard | 708 | 703 | 5 |
| 1987-09-08 | vs NYA | 137 | W 8-6 | 65-72 | 5 | 29,468 | Al Nipper | Bill Gullickson | Al Nipper | Bill Gullickson | Calvin Schiraldi | 716 | 709 | 7 |
| 1987-09-09 | vs NYA | 138 | W 5-3 | 66-72 | 5 | 32,025 | Roger Clemens | Charles Hudson | Roger Clemens | Charles Hudson | | 721 | 712 | 9 |
| 1987-09-10 | vs BAL | 139 | W 5-4 | 67-72 | 5 | 19,639 | Rob Woodward | Jose Mesa | Joe Sambito | Tom Niedenfuer | Wes Gardner | 726 | 716 | 10 |
| 1987-09-11 | vs BAL | 140 | W 9-3 | 68-72 | 5 | 24,938 | Jeff Sellers | John Habyan | Jeff Sellers | John Habyan | | 735 | 719 | 16 |
| 1987-09-12 | vs BAL | 141 | W 4-3 | 69-72 | 5 | 27,409 | Bruce Hurst | Jeff Ballard | Bruce Hurst | Tom Niedenfuer | | 739 | 722 | 17 |
| 1987-09-14 | @ DET | 142 | L 0-3 | 69-73 | 5 | 23,287 | Roger Clemens | Doyle Alexander | Doyle Alexander | Roger Clemens | Mike Henneman | 739 | 725 | 14 |
| 1987-09-15 | @ DET | 143 | L 8-9 | 69-74 | 5 | 20,398 | Al Nipper | Frank Tanana | Dan Petry | Steve Crawford | Mike Henneman | 747 | 734 | 13 |
| 1987-09-16 | @ DET | 144 | L 1-4 | 69-75 | 5 | 22,341 | Jeff Sellers | Jack Morris | Jack Morris | Jeff Sellers | | 748 | 738 | 10 |
| 1987-09-18 | @ BAL | 145 | L 4-9 | 70-76 | 5 | 0 | Bruce Hurst | John Habyan | John Habyan | Bruce Hurst | Jack O'Connor | 752 | 747 | 5 |
| 1987-09-18 | @ BAL | 146 | W 10-7 | 70-76 | 5 | 19,000 | Rob Woodward | Jeff Ballard | Rob Woodward | Jeff Ballard | | 762 | 754 | 8 |
| 1987-09-20 | @ BAL | 147 | W 5-1 | 72-76 | 5 | 0 | Roger Clemens | Jose Mesa | Roger Clemens | Jose Mesa | | 767 | 755 | 12 |
| 1987-09-20 | @ BAL | 148 | W 6-3 | 72-76 | 5 | 20,647 | John Leister | Eric Bell | Wes Gardner | Luis DeLeon | | 773 | 758 | 15 |
| 1987-09-21 | vs DET | 149 | W 9-4 | 73-76 | 5 | 20,376 | Al Nipper | Nate Snell | Al Nipper | Nate Snell | | 782 | 762 | 20 |
| 1987-09-22 | vs DET | 150 | L 5-8 | 73-77 | 5 | 20,189 | Rob Woodward | Walt Terrell | Walt Terrell | Rob Woodward | Dickie Noles | 787 | 770 | 17 |
| 1987-09-23 | vs DET | 151 | L 0-4 | 73-78 | 5 | 23,798 | Bruce Hurst | Doyle Alexander | Doyle Alexander | Bruce Hurst | | 787 | 774 | 13 |
| 1987-09-24 | @ MIL | 152 | L 6-7 | 73-79 | 5 | 7,745 | Jeff Sellers | Chris Bosio | Mark Clear | Joe Sambito | | 793 | 781 | 12 |
| 1987-09-25 | @ MIL | 153 | W 9-2 | 74-79 | 5 | 12,878 | Roger Clemens | Juan Nieves | Roger Clemens | Juan Nieves | | 802 | 783 | 19 |
| 1987-09-26 | @ MIL | 154 | L 2-3 | 74-80 | 5 | 19,206 | Al Nipper | Len Barker | Dave Stapleton | Al Nipper | | 804 | 786 | 18 |
| 1987-09-27 | @ MIL | 155 | L 6-9 | 74-81 | 5 | 26,175 | John Leister | Teddy Higuera | Ray Burris | Bob Stanley | Chuck Crim | 810 | 795 | 15 |
| 1987-09-28 | @ NYA | 156 | L 7-9 | 74-82 | 5 | 20,320 | Rob Woodward | Bill Gullickson | Bill Fulton | Joe Sambito | | 817 | 804 | 13 |
| 1987-09-29 | @ NYA | 157 | L 0-6 | 74-83 | 5 | 20,204 | Bruce Hurst | Charles Hudson | Charles Hudson | Bruce Hurst | | 817 | 810 | 7 |
| 1987-09-30 | @ NYA | 158 | W 7-0 | 75-83 | 5 | 20,280 | Roger Clemens | Al Leiter | Roger Clemens | Al Leiter | | 824 | 810 | 14 |
| 1987-10-01 | @ NYA | 159 | W 7-5 | 76-83 | 5 | 20,176 | Al Nipper | Pete Filson | Al Nipper | Dave Righetti | | 831 | 815 | 16 |
| 1987-10-02 | vs MIL | 160 | W 3-2 | 77-83 | 5 | 20,077 | Jeff Sellers | Teddy Higuera | Wes Gardner | Teddy Higuera | | 834 | 817 | 17 |
| 1987-10-03 | vs MIL | 161 | L 4-8 | 77-84 | 5 | 21,962 | John Leister | Bill Wegman | Bill Wegman | John Leister | Chuck Crim | 838 | 825 | 13 |
| 1987-10-04 | vs MIL | 162 | W 4-0 | 78-84 | 5 | 25,454 | Roger Clemens | Chris Bosio | Roger Clemens | Chris Bosio | | 842 | 825 | 17 |