| 1987-04-07 | vs SEA | 1 | W 7-1 | 1-0 | 3 | 37,097 | Mike Witt | Mark Langston | Mike Witt | Mark Langston | | 7 | 1 | 6 |
| 1987-04-08 | vs SEA | 2 | W 7-1 | 2-0 | 2 | 24,703 | John Candelaria | Mike Moore | John Candelaria | Mike Moore | | 14 | 2 | 12 |
| 1987-04-09 | vs SEA | 3 | L 2-7 | 2-1 | 3 | 24,244 | Don Sutton | Scott Bankhead | Scott Bankhead | Don Sutton | Steve Shields | 16 | 9 | 7 |
| 1987-04-10 | @ OAK | 4 | W 6-4 | 3-1 | 2 | 46,120 | Kirk McCaskill | Dave Stewart | Kirk McCaskill | Dave Stewart | Donnie Moore | 22 | 13 | 9 |
| 1987-04-11 | @ OAK | 5 | W 6-3 | 4-1 | 2 | 30,136 | Urbano Lugo | Jose Rijo | Willie Fraser | Bill Krueger | Gary Lucas | 28 | 16 | 12 |
| 1987-04-12 | @ OAK | 6 | L 1-7 | 4-2 | 2 | 37,162 | Mike Witt | Curt Young | Curt Young | Mike Witt | | 29 | 23 | 6 |
| 1987-04-13 | @ SEA | 7 | W 5-3 | 5-2 | 2 | 11,834 | John Candelaria | Mike Moore | Donnie Moore | Ed Nunez | | 34 | 26 | 8 |
| 1987-04-14 | @ SEA | 8 | L 4-6 | 5-3 | 2 | 7,301 | Don Sutton | Scott Bankhead | Scott Bankhead | Don Sutton | Ed Nunez | 38 | 32 | 6 |
| 1987-04-15 | @ SEA | 9 | W 4-0 | 6-3 | 2 | 8,333 | Kirk McCaskill | Mike Morgan | Kirk McCaskill | Mike Morgan | | 42 | 32 | 10 |
| 1987-04-17 | vs MIN | 10 | W 2-1 | 7-3 | 2 | 36,175 | Mike Witt | Bert Blyleven | Mike Witt | Bert Blyleven | | 44 | 33 | 11 |
| 1987-04-18 | vs MIN | 11 | W 1-0 | 8-3 | 1 | 36,881 | John Candelaria | Frank Viola | John Candelaria | Frank Viola | Donnie Moore | 45 | 33 | 12 |
| 1987-04-19 | vs MIN | 12 | L 5-6 | 8-4 | 2 | 49,627 | Don Sutton | Mark Portugal | Mark Portugal | Don Sutton | Jeff Reardon | 50 | 39 | 11 |
| 1987-04-20 | vs OAK | 13 | L 5-10 | 8-5 | 2 | 26,821 | Kirk McCaskill | Dave Stewart | Dave Stewart | Gary Lucas | Jay Howell | 55 | 49 | 6 |
| 1987-04-21 | vs OAK | 14 | W 8-5 | 9-5 | 2 | 27,388 | Urbano Lugo | Jose Rijo | Mike Cook | Dennis Eckersley | Willie Fraser | 63 | 54 | 9 |
| 1987-04-22 | vs OAK | 15 | L 6-7 | 9-6 | 2 | 30,157 | Mike Witt | Curt Young | Curt Young | Mike Witt | Jay Howell | 69 | 61 | 8 |
| 1987-04-23 | @ MIN | 16 | W 7-3 | 10-6 | 2 | 14,204 | John Candelaria | Frank Viola | John Candelaria | Frank Viola | Donnie Moore | 76 | 64 | 12 |
| 1987-04-24 | @ MIN | 17 | W 8-1 | 11-6 | 1 | 20,116 | Don Sutton | Mark Portugal | Don Sutton | Mark Portugal | | 84 | 65 | 19 |
| 1987-04-25 | @ MIN | 18 | L 7-8 | 11-7 | 2 | 51,717 | Willie Fraser | Mike Smithson | Jeff Reardon | Chuck Finley | | 91 | 73 | 18 |
| 1987-04-26 | @ MIN | 19 | L 5-10 | 11-8 | 2 | 19,116 | Urbano Lugo | Bert Blyleven | George Frazier | Mike Cook | | 96 | 83 | 13 |
| 1987-04-27 | vs MIL | 20 | L 7-10 | 11-9 | 2 | 32,290 | Mike Witt | Juan Nieves | Paul Mirabella | Chuck Finley | | 103 | 93 | 10 |
| 1987-04-28 | vs MIL | 21 | W 10-5 | 12-9 | 2 | 31,358 | John Candelaria | Mark Ciardi | DeWayne Buice | Chuck Crim | | 113 | 98 | 15 |
| 1987-04-29 | vs DET | 22 | L 1-2 | 12-10 | 2 | 26,126 | Don Sutton | Dan Petry | Eric King | Donnie Moore | | 114 | 100 | 14 |
| 1987-04-30 | vs DET | 23 | L 4-12 | 12-11 | 3 | 27,656 | Willie Fraser | Jack Morris | Jack Morris | Willie Fraser | | 118 | 112 | 6 |
| 1987-05-01 | vs BOS | 24 | L 3-12 | 12-12 | 3 | 50,352 | Urbano Lugo | Roger Clemens | Roger Clemens | Urbano Lugo | | 121 | 124 | -3 |
| 1987-05-02 | vs BOS | 25 | W 4-2 | 13-12 | 2 | 43,726 | Mike Witt | Bob Stanley | Mike Witt | Bob Stanley | | 125 | 126 | -1 |
| 1987-05-03 | vs BOS | 26 | W 11-4 | 14-12 | 2 | 40,018 | John Candelaria | Al Nipper | John Candelaria | Al Nipper | | 136 | 130 | 6 |
| 1987-05-05 | @ MIL | 27 | W 2-0 | 15-12 | 2 | 13,137 | Don Sutton | Bill Wegman | Don Sutton | Bill Wegman | Donnie Moore | 138 | 130 | 8 |
| 1987-05-06 | @ MIL | 28 | W 3-0 | 16-12 | 1 | 13,552 | Mike Witt | Mike Birkbeck | Mike Witt | Mike Birkbeck | DeWayne Buice | 141 | 130 | 11 |
| 1987-05-08 | @ BOS | 29 | L 4-6 | 16-13 | 2 | 32,072 | John Candelaria | Bob Stanley | Joe Sambito | DeWayne Buice | | 145 | 136 | 9 |
| 1987-05-09 | @ BOS | 30 | W 8-1 | 17-13 | 2 | 34,205 | Willie Fraser | Al Nipper | Willie Fraser | Al Nipper | | 153 | 137 | 16 |
| 1987-05-10 | @ BOS | 31 | L 0-7 | 17-14 | 3 | 32,121 | Don Sutton | Bruce Hurst | Bruce Hurst | Don Sutton | | 153 | 144 | 9 |
| 1987-05-11 | @ DET | 32 | W 5-1 | 18-14 | 2 | 11,079 | Mike Witt | Walt Terrell | Mike Witt | Walt Terrell | DeWayne Buice | 158 | 145 | 13 |
| 1987-05-12 | @ DET | 33 | L 2-15 | 18-15 | 3 | 11,579 | Urbano Lugo | Dan Petry | Dan Petry | Urbano Lugo | | 160 | 160 | 0 |
| 1987-05-13 | @ DET | 34 | L 7-10 | 18-16 | 3 | 11,659 | John Candelaria | Frank Tanana | Frank Tanana | John Candelaria | | 167 | 170 | -3 |
| 1987-05-15 | vs BAL | 35 | W 7-6 | 19-16 | 3 | 34,755 | Don Sutton | Eric Bell | Donnie Moore | Jack O'Connor | | 174 | 176 | -2 |
| 1987-05-16 | vs BAL | 36 | L 2-4 | 19-17 | 3 | 35,463 | Mike Witt | Scott McGregor | Scott McGregor | Mike Witt | Jack O'Connor | 176 | 180 | -4 |
| 1987-05-17 | vs BAL | 37 | L 2-3 | 19-18 | 4 | 43,207 | Willie Fraser | Mike Flanagan | Dave J. Schmidt | DeWayne Buice | Don Aase | 178 | 183 | -5 |
| 1987-05-18 | vs TOR | 38 | L 0-12 | 19-19 | 4 | 23,710 | Mike Cook | Jim Clancy | Jim Clancy | Mike Cook | | 178 | 195 | -17 |
| 1987-05-19 | vs TOR | 39 | W 2-1 | 20-19 | 3 | 23,622 | Don Sutton | Dave Stieb | DeWayne Buice | Jeff Musselman | Donnie Moore | 180 | 196 | -16 |
| 1987-05-20 | vs TOR | 40 | W 5-4 | 21-19 | 3 | 23,766 | Jack Lazorko | Jimmy Key | Gary Lucas | Tom Henke | | 185 | 200 | -15 |
| 1987-05-22 | vs NYA | 41 | L 2-7 | 21-20 | 3 | 50,110 | Mike Witt | Rick Rhoden | Rick Rhoden | Mike Witt | | 187 | 207 | -20 |
| 1987-05-23 | vs NYA | 42 | L 0-3 | 21-21 | 4 | 43,781 | Willie Fraser | Joe Niekro | Joe Niekro | Willie Fraser | Dave Righetti | 187 | 210 | -23 |
| 1987-05-24 | vs NYA | 43 | L 8-10 | 21-22 | 4 | 40,949 | Don Sutton | Dennis Rasmussen | Dave Righetti | Donnie Moore | | 195 | 220 | -25 |
| 1987-05-25 | vs NYA | 44 | L 3-6 | 21-23 | 4 | 34,762 | Jack Lazorko | Tommy John | Tommy John | Jack Lazorko | Tim Stoddard | 198 | 226 | -28 |
| 1987-05-27 | @ BAL | 45 | L 6-8 | 21-24 | 5 | 26,741 | Mike Witt | Scott McGregor | John Habyan | Gary Lucas | Tom Niedenfuer | 204 | 234 | -30 |
| 1987-05-28 | @ BAL | 46 | L 7-8 | 21-25 | 5 | 28,361 | Willie Fraser | Mike Boddicker | Mark Williamson | DeWayne Buice | | 211 | 242 | -31 |
| 1987-05-29 | @ TOR | 47 | L 1-3 | 21-26 | 5 | 33,107 | Don Sutton | Dave Stieb | Dave Stieb | Don Sutton | Tom Henke | 212 | 245 | -33 |
| 1987-05-30 | @ TOR | 48 | L 3-4 | 21-27 | 6 | 36,055 | Jack Lazorko | Jimmy Key | Mark Eichhorn | Jack Lazorko | | 215 | 249 | -34 |
| 1987-05-31 | @ TOR | 49 | L 2-7 | 21-28 | 6 | 40,313 | John Candelaria | John Cerutti | John Cerutti | John Candelaria | | 217 | 256 | -39 |
| 1987-06-01 | @ NYA | 50 | W 9-2 | 22-28 | 5 | 21,154 | Mike Witt | Charles Hudson | Mike Witt | Charles Hudson | | 226 | 258 | -32 |
| 1987-06-02 | @ NYA | 51 | L 2-3 | 22-29 | 6 | 23,552 | Willie Fraser | Rick Rhoden | Dave Righetti | Willie Fraser | | 228 | 261 | -33 |
| 1987-06-03 | @ NYA | 52 | L 3-9 | 22-30 | 7 | 18,244 | Don Sutton | Dennis Rasmussen | Rich Bordi | Don Sutton | | 231 | 270 | -39 |
| 1987-06-04 | vs CHA | 53 | W 3-2 | 23-30 | 5 | 25,234 | Jack Lazorko | Jose DeLeon | Jack Lazorko | Jose DeLeon | | 234 | 272 | -38 |
| 1987-06-05 | vs CHA | 54 | W 6-4 | 24-30 | 5 | 39,585 | John Candelaria | Neil Allen | John Candelaria | Neil Allen | DeWayne Buice | 240 | 276 | -36 |
| 1987-06-06 | vs CHA | 55 | W 2-1 | 25-30 | 5 | 24,763 | Mike Witt | Richard Dotson | Mike Witt | Bob James | | 242 | 277 | -35 |
| 1987-06-07 | vs CHA | 56 | L 0-4 | 25-31 | 5 | 42,573 | Willie Fraser | Bill Long | Bill Long | Willie Fraser | | 242 | 281 | -39 |
| 1987-06-08 | vs CLE | 57 | L 0-2 | 25-32 | 5 | 23,752 | Don Sutton | Phil Niekro | Phil Niekro | Don Sutton | Scott Bailes | 242 | 283 | -41 |
| 1987-06-09 | vs CLE | 58 | W 6-5 | 26-32 | 5 | 23,252 | Jack Lazorko | Ken Schrom | Jack Lazorko | Rich Yett | DeWayne Buice | 248 | 288 | -40 |
| 1987-06-10 | vs CLE | 59 | W 10-7 | 27-32 | 5 | 24,467 | John Candelaria | Tom Candiotti | Greg Minton | Scott Bailes | | 258 | 295 | -37 |
| 1987-06-12 | @ KCA | 60 | L 0-1 | 27-33 | 5 | 35,415 | Mike Witt | Bret Saberhagen | Bret Saberhagen | Mike Witt | | 258 | 296 | -38 |
| 1987-06-13 | @ KCA | 61 | W 4-0 | 28-33 | 5 | 39,650 | Willie Fraser | Mark Gubicza | Willie Fraser | Mark Gubicza | | 262 | 296 | -34 |
| 1987-06-14 | @ KCA | 62 | W 12-0 | 29-33 | 5 | 29,260 | Don Sutton | Danny Jackson | Don Sutton | Danny Jackson | | 274 | 296 | -22 |
| 1987-06-15 | vs TEX | 63 | L 7-9 | 29-34 | 5 | 23,064 | Jack Lazorko | Mike Jeffcoat | Jeff Russell | Chuck Finley | Dale Mohorcic | 281 | 305 | -24 |
| 1987-06-16 | vs TEX | 64 | L 4-5 | 29-35 | 5 | 25,660 | John Candelaria | Jose Guzman | Jose Guzman | John Candelaria | Dale Mohorcic | 285 | 310 | -25 |
| 1987-06-17 | vs TEX | 65 | W 6-1 | 30-35 | 5 | 23,829 | Mike Witt | Greg Harris | Mike Witt | Greg Harris | | 291 | 311 | -20 |
| 1987-06-18 | vs KCA | 66 | L 4-10 | 30-36 | 5 | 42,923 | Willie Fraser | Mark Gubicza | Mark Gubicza | Willie Fraser | | 295 | 321 | -26 |
| 1987-06-19 | vs KCA | 67 | L 0-2 | 30-37 | 6 | 32,797 | Don Sutton | Danny Jackson | Danny Jackson | Don Sutton | | 295 | 323 | -28 |
| 1987-06-20 | vs KCA | 68 | L 4-8 | 30-38 | 6 | 39,510 | Jack Lazorko | Charlie Leibrandt | Charlie Leibrandt | Jack Lazorko | | 299 | 331 | -32 |
| 1987-06-21 | vs KCA | 69 | W 8-0 | 31-38 | 6 | 47,797 | Jerry Reuss | Bob Stoddard | Jerry Reuss | Bob Stoddard | | 307 | 331 | -24 |
| 1987-06-22 | @ TEX | 70 | W 7-3 | 32-38 | 5 | 25,118 | Mike Witt | Greg Harris | DeWayne Buice | Greg Harris | Greg Minton | 314 | 334 | -20 |
| 1987-06-23 | @ TEX | 71 | W 8-6 | 33-38 | 5 | 32,996 | Willie Fraser | Charlie Hough | Willie Fraser | Charlie Hough | Greg Minton | 322 | 340 | -18 |
| 1987-06-24 | @ TEX | 72 | W 4-1 | 34-38 | 5 | 17,218 | Don Sutton | Mike Loynd | Don Sutton | Mike Loynd | DeWayne Buice | 326 | 341 | -15 |
| 1987-06-26 | @ CHA | 73 | W 3-1 | 35-38 | 5 | 19,086 | Jerry Reuss | Jose DeLeon | Jerry Reuss | Jose DeLeon | Greg Minton | 329 | 342 | -13 |
| 1987-06-27 | @ CHA | 74 | W 3-1 | 36-38 | 5 | 15,998 | Mike Witt | Floyd Bannister | Mike Witt | Floyd Bannister | DeWayne Buice | 332 | 343 | -11 |
| 1987-06-28 | @ CHA | 75 | W 13-3 | 37-38 | 5 | 15,268 | Willie Fraser | Bill Long | Willie Fraser | Bill Long | | 345 | 346 | -1 |
| 1987-06-29 | @ CLE | 76 | W 11-4 | 38-38 | 5 | 5,888 | Don Sutton | Greg Swindell | Don Sutton | Greg Swindell | Greg Minton | 356 | 350 | 6 |
| 1987-06-30 | @ CLE | 77 | L 1-2 | 38-39 | 5 | 12,337 | Jack Lazorko | Phil Niekro | Phil Niekro | Jack Lazorko | Scott Bailes | 357 | 352 | 5 |
| 1987-07-01 | @ CLE | 78 | W 10-5 | 39-39 | 5 | 5,005 | Jerry Reuss | Steve Carlton | Jerry Reuss | Steve Carlton | DeWayne Buice | 367 | 357 | 10 |
| 1987-07-02 | vs MIL | 79 | W 9-7 | 40-39 | 5 | 28,116 | Mike Witt | Juan Nieves | Chuck Finley | Mark Clear | | 376 | 364 | 12 |
| 1987-07-03 | vs MIL | 80 | L 4-6 | 40-40 | 5 | 32,759 | Willie Fraser | Teddy Higuera | Teddy Higuera | Willie Fraser | | 380 | 370 | 10 |
| 1987-07-04 | vs MIL | 81 | L 1-2 | 40-41 | 5 | 62,531 | Don Sutton | Chris Bosio | Chris Bosio | Don Sutton | Dan Plesac | 381 | 372 | 9 |
| 1987-07-05 | vs MIL | 82 | W 4-3 | 41-41 | 4 | 27,525 | Jack Lazorko | Mark Knudson | Chuck Finley | Mark Clear | | 385 | 375 | 10 |
| 1987-07-06 | vs BOS | 83 | W 10-7 | 42-41 | 4 | 28,953 | Jerry Reuss | Roger Clemens | Greg Minton | Wes Gardner | | 395 | 382 | 13 |
| 1987-07-07 | vs BOS | 84 | W 9-4 | 43-41 | 4 | 31,526 | Mike Witt | Al Nipper | Mike Witt | Al Nipper | DeWayne Buice | 404 | 386 | 18 |
| 1987-07-08 | vs BOS | 85 | W 5-3 | 44-41 | 4 | 32,576 | Willie Fraser | Jeff Sellers | Willie Fraser | Jeff Sellers | DeWayne Buice | 409 | 389 | 20 |
| 1987-07-09 | vs DET | 86 | W 5-2 | 45-41 | 4 | 30,966 | Don Sutton | Jack Morris | Don Sutton | Jack Morris | Greg Minton | 414 | 391 | 23 |
| 1987-07-10 | vs DET | 87 | L 4-9 | 45-42 | 4 | 31,073 | Jack Lazorko | Dan Petry | Eric King | Jack Lazorko | | 418 | 400 | 18 |
| 1987-07-11 | vs DET | 88 | L 5-12 | 45-43 | 4 | 44,219 | Jerry Reuss | Walt Terrell | Mike Henneman | Jerry Reuss | | 423 | 412 | 11 |
| 1987-07-12 | vs DET | 89 | W 5-4 | 46-43 | 4 | 42,682 | Mike Witt | Frank Tanana | Mike Witt | Frank Tanana | Greg Minton | 428 | 416 | 12 |
| 1987-07-16 | @ MIL | 90 | L 4-6 | 46-44 | 4 | 24,325 | Kirk McCaskill | Teddy Higuera | Teddy Higuera | Kirk McCaskill | Dan Plesac | 432 | 422 | 10 |
| 1987-07-17 | @ MIL | 91 | L 2-12 | 46-45 | 4 | 19,858 | Mike Witt | Bill Wegman | Bill Wegman | Mike Witt | | 434 | 434 | 0 |
| 1987-07-18 | @ MIL | 92 | W 12-6 | 47-45 | 4 | 35,038 | Don Sutton | Chris Bosio | DeWayne Buice | Dan Plesac | | 446 | 440 | 6 |
| 1987-07-19 | @ MIL | 93 | W 8-5 | 48-45 | 3 | 30,635 | Jerry Reuss | Juan Nieves | Jack Lazorko | Jay Aldrich | Greg Minton | 454 | 445 | 9 |
| 1987-07-20 | @ BOS | 94 | W 3-2 | 49-45 | 3 | 27,322 | Willie Fraser | Jeff Sellers | Greg Minton | Jeff Sellers | DeWayne Buice | 457 | 447 | 10 |
| 1987-07-21 | @ BOS | 95 | L 0-3 | 49-46 | 3 | 30,301 | Kirk McCaskill | Roger Clemens | Roger Clemens | Kirk McCaskill | | 457 | 450 | 7 |
| 1987-07-22 | @ BOS | 96 | W 6-5 | 50-46 | 3 | 31,729 | Mike Witt | Oil Can Boyd | Mike Witt | Oil Can Boyd | Greg Minton | 463 | 455 | 8 |
| 1987-07-24 | @ DET | 97 | L 3-6 | 50-47 | 3 | 33,275 | Don Sutton | Jack Morris | Mike Henneman | Chuck Finley | | 466 | 461 | 5 |
| 1987-07-25 | @ DET | 98 | L 4-5 | 50-48 | 3 | 34,973 | Jerry Reuss | Dan Petry | Mike Henneman | Greg Minton | | 470 | 466 | 4 |
| 1987-07-26 | @ DET | 99 | L 2-6 | 50-49 | 3 | 31,339 | Willie Fraser | Walt Terrell | Walt Terrell | Willie Fraser | | 472 | 472 | 0 |
| 1987-07-27 | @ OAK | 100 | L 1-6 | 50-50 | 5 | 20,153 | Kirk McCaskill | Dave Stewart | Dave Stewart | Kirk McCaskill | | 473 | 478 | -5 |
| 1987-07-28 | @ OAK | 101 | W 9-2 | 51-50 | 3 | 16,326 | Mike Witt | Joaquin Andujar | Mike Witt | Joaquin Andujar | | 482 | 480 | 2 |
| 1987-07-29 | @ OAK | 102 | W 5-4 | 52-50 | 3 | 22,616 | Don Sutton | Steve Ontiveros | Don Sutton | Steve Ontiveros | DeWayne Buice | 487 | 484 | 3 |
| 1987-07-31 | vs SEA | 103 | W 8-2 | 53-50 | 2 | 32,471 | Jerry Reuss | Scott Bankhead | Jack Lazorko | Scott Bankhead | Greg Minton | 495 | 486 | 9 |
| 1987-08-01 | vs SEA | 104 | W 4-3 | 54-50 | 2 | 42,142 | Willie Fraser | Mike Moore | Willie Fraser | Mike Moore | DeWayne Buice | 499 | 489 | 10 |
| 1987-08-02 | vs SEA | 105 | L 4-5 | 54-51 | 3 | 28,318 | Kirk McCaskill | Mark Langston | Steve Shields | Greg Minton | | 503 | 494 | 9 |
| 1987-08-03 | vs MIN | 106 | L 3-11 | 54-52 | 3 | 33,983 | Mike Witt | Joe Niekro | Dan Schatzeder | Mike Witt | | 506 | 505 | 1 |
| 1987-08-04 | vs MIN | 107 | W 12-3 | 55-52 | 3 | 37,371 | Don Sutton | Steve Carlton | Don Sutton | Steve Carlton | Gary Lucas | 518 | 508 | 10 |
| 1987-08-05 | vs MIN | 108 | W 6-1 | 56-52 | 3 | 34,059 | John Candelaria | Bert Blyleven | John Candelaria | Bert Blyleven | | 524 | 509 | 15 |
| 1987-08-06 | @ SEA | 109 | L 4-15 | 56-53 | 3 | 11,065 | Willie Fraser | Mike Moore | Mike Moore | Willie Fraser | | 528 | 524 | 4 |
| 1987-08-07 | @ SEA | 110 | L 0-14 | 56-54 | 3 | 12,464 | Kirk McCaskill | Mark Langston | Mark Langston | Kirk McCaskill | | 528 | 538 | -10 |
| 1987-08-08 | @ SEA | 111 | L 3-5 | 56-55 | 3 | 15,540 | Mike Witt | Mike Morgan | Mike Morgan | Mike Witt | Bill Wilkinson | 531 | 543 | -12 |
| 1987-08-09 | @ SEA | 112 | W 7-5 | 57-55 | 2 | 16,191 | Don Sutton | Lee Guetterman | DeWayne Buice | Dennis Powell | | 538 | 548 | -10 |
| 1987-08-11 | @ MIN | 113 | L 2-7 | 57-56 | 3 | 39,163 | John Candelaria | Frank Viola | Frank Viola | John Candelaria | | 540 | 555 | -15 |
| 1987-08-12 | @ MIN | 114 | W 8-2 | 58-56 | 2 | 33,033 | Kirk McCaskill | Les Straker | Kirk McCaskill | Les Straker | | 548 | 557 | -9 |
| 1987-08-13 | @ MIN | 115 | W 5-1 | 59-56 | 2 | 35,837 | Mike Witt | Steve Carlton | Mike Witt | Steve Carlton | | 553 | 558 | -5 |
| 1987-08-14 | vs OAK | 116 | L 6-7 | 59-57 | 2 | 36,616 | Don Sutton | Curt Young | Rick Rodriguez | DeWayne Buice | Dennis Eckersley | 559 | 565 | -6 |
| 1987-08-15 | vs OAK | 117 | L 3-13 | 59-58 | 3 | 43,868 | John Candelaria | Dave Stewart | Dave Stewart | John Candelaria | | 562 | 578 | -16 |
| 1987-08-16 | vs OAK | 118 | L 6-9 | 59-59 | 3 | 40,457 | Willie Fraser | Steve Ontiveros | Greg Cadaret | Chuck Finley | Dennis Eckersley | 568 | 587 | -19 |
| 1987-08-17 | vs OAK | 119 | W 6-4 | 60-59 | 3 | 30,090 | Mike Witt | Jose Rijo | Mike Witt | Dave Leiper | DeWayne Buice | 574 | 591 | -17 |
| 1987-08-18 | vs BAL | 120 | L 1-4 | 60-60 | 3 | 25,360 | Kirk McCaskill | Ken Dixon | Ken Dixon | Kirk McCaskill | John Habyan | 575 | 595 | -20 |
| 1987-08-19 | vs BAL | 121 | L 1-2 | 60-61 | 4 | 25,824 | Don Sutton | Mike Boddicker | Mike Boddicker | Don Sutton | Tom Niedenfuer | 576 | 597 | -21 |
| 1987-08-20 | vs BAL | 122 | L 2-4 | 60-62 | 4 | 27,004 | John Candelaria | Eric Bell | Mark Williamson | DeWayne Buice | | 578 | 601 | -23 |
| 1987-08-21 | vs TOR | 123 | W 3-1 | 61-62 | 4 | 47,925 | Jerry Reuss | Phil Niekro | Jerry Reuss | Phil Niekro | Greg Minton | 581 | 602 | -21 |
| 1987-08-22 | vs TOR | 124 | L 0-2 | 61-63 | 4 | 34,209 | Mike Witt | Jose Nunez | Jose Nunez | Mike Witt | Tom Henke | 581 | 604 | -23 |
| 1987-08-23 | vs TOR | 125 | W 5-2 | 62-63 | 3 | 42,000 | Kirk McCaskill | Dave Stieb | Kirk McCaskill | Dave Stieb | DeWayne Buice | 586 | 606 | -20 |
| 1987-08-24 | vs NYA | 126 | L 2-3 | 62-64 | 3 | 38,742 | Don Sutton | Tommy John | Charles Hudson | Gary Lucas | Dave Righetti | 588 | 609 | -21 |
| 1987-08-25 | vs NYA | 127 | W 5-1 | 63-64 | 3 | 43,905 | John Candelaria | Dennis Rasmussen | John Candelaria | Dennis Rasmussen | | 593 | 610 | -17 |
| 1987-08-27 | @ BAL | 128 | L 5-9 | 63-65 | 4 | 25,951 | Jerry Reuss | Mike Flanagan | Mike Flanagan | Jerry Reuss | | 598 | 619 | -21 |
| 1987-08-28 | @ BAL | 129 | L 5-6 | 63-66 | 4 | 20,403 | Mike Witt | John Habyan | Mark Williamson | Chuck Finley | | 603 | 625 | -22 |
| 1987-08-29 | @ BAL | 130 | W 6-5 | 64-66 | 4 | 16,491 | Kirk McCaskill | Mike Boddicker | Willie Fraser | Mark Williamson | | 609 | 630 | -21 |
| 1987-08-30 | @ BAL | 131 | W 6-2 | 65-66 | 4 | 23,384 | Don Sutton | Eric Bell | Don Sutton | Eric Bell | | 615 | 632 | -17 |
| 1987-08-31 | @ TOR | 132 | W 8-7 | 66-66 | 3 | 30,224 | John Candelaria | Jose Nunez | Willie Fraser | Tom Henke | Gary Lucas | 623 | 639 | -16 |
| 1987-09-01 | @ TOR | 133 | L 3-4 | 66-67 | 3 | 31,101 | Mike Witt | Jimmy Key | Jeff Musselman | Mike Witt | | 626 | 643 | -17 |
| 1987-09-02 | @ TOR | 134 | L 6-7 | 66-68 | 3 | 33,408 | Jerry Reuss | Dave Stieb | David Wells | DeWayne Buice | | 632 | 650 | -18 |
| 1987-09-04 | @ NYA | 135 | L 4-8 | 66-69 | 4 | 24,135 | Kirk McCaskill | Bill Gullickson | Bill Gullickson | Kirk McCaskill | Pat Clements | 636 | 658 | -22 |
| 1987-09-05 | @ NYA | 136 | L 6-7 | 66-70 | 4 | 31,566 | Don Sutton | Ron Guidry | Ron Guidry | Don Sutton | Dave Righetti | 642 | 665 | -23 |
| 1987-09-06 | @ NYA | 137 | W 3-1 | 67-70 | 4 | 48,214 | John Candelaria | Tommy John | John Candelaria | Tommy John | DeWayne Buice | 645 | 666 | -21 |
| 1987-09-07 | vs KCA | 138 | L 2-5 | 67-71 | 4 | 28,034 | Mike Witt | Charlie Leibrandt | Charlie Leibrandt | Mike Witt | Gene Garber | 647 | 671 | -24 |
| 1987-09-08 | vs KCA | 139 | L 2-4 | 67-72 | 4 | 25,637 | Jerry Reuss | Mark Gubicza | Mark Gubicza | Willie Fraser | John Davis | 649 | 675 | -26 |
| 1987-09-10 | vs TEX | 140 | W 8-7 | 68-72 | 4 | 22,589 | Don Sutton | Greg Harris | DeWayne Buice | Steve Howe | | 657 | 682 | -25 |
| 1987-09-11 | vs TEX | 141 | L 2-7 | 68-73 | 4 | 28,693 | John Candelaria | Jose Guzman | Jose Guzman | John Candelaria | | 659 | 689 | -30 |
| 1987-09-12 | vs TEX | 142 | L 3-4 | 68-74 | 4 | 29,551 | Mike Witt | Charlie Hough | Charlie Hough | Mike Witt | Steve Howe | 662 | 693 | -31 |
| 1987-09-13 | vs TEX | 143 | L 2-8 | 68-75 | 5 | 34,766 | Jerry Reuss | Paul Kilgus | Jeff Russell | Jerry Reuss | Mitch Williams | 664 | 701 | -37 |
| 1987-09-14 | @ KCA | 144 | L 5-8 | 68-76 | 5 | 22,451 | Don Sutton | Melido Perez | Buddy Black | Jack Lazorko | Gene Garber | 669 | 709 | -40 |
| 1987-09-15 | @ KCA | 145 | W 7-1 | 69-76 | 5 | 17,682 | Willie Fraser | Danny Jackson | Willie Fraser | Danny Jackson | | 676 | 710 | -34 |
| 1987-09-16 | @ KCA | 146 | W 6-4 | 70-76 | 5 | 18,739 | Chuck Finley | Bret Saberhagen | Greg Minton | Bret Saberhagen | DeWayne Buice | 682 | 714 | -32 |
| 1987-09-17 | @ KCA | 147 | L 6-7 | 70-77 | 5 | 26,014 | Mike Witt | Charlie Leibrandt | John Davis | Greg Minton | | 688 | 721 | -33 |
| 1987-09-18 | @ TEX | 148 | L 1-5 | 70-78 | 5 | 12,243 | Jerry Reuss | Jose Guzman | Jose Guzman | Jerry Reuss | | 689 | 726 | -37 |
| 1987-09-19 | @ TEX | 149 | L 3-4 | 70-79 | 5 | 27,343 | Don Sutton | Bobby Witt | Mitch Williams | DeWayne Buice | | 692 | 730 | -38 |
| 1987-09-20 | @ TEX | 150 | L 1-2 | 70-80 | 5 | 11,496 | Willie Fraser | Charlie Hough | Steve Howe | Greg Minton | | 693 | 732 | -39 |
| 1987-09-21 | vs CHA | 151 | L 3-5 | 70-81 | 6 | 21,969 | Chuck Finley | Jose DeLeon | Jose DeLeon | Chuck Finley | Bobby Thigpen | 696 | 737 | -41 |
| 1987-09-22 | vs CHA | 152 | W 5-3 | 71-81 | 5 | 23,002 | Mike Witt | Dave LaPoint | Mike Witt | Bob James | DeWayne Buice | 701 | 740 | -39 |
| 1987-09-23 | vs CHA | 153 | W 10-6 | 72-81 | 5 | 22,188 | Jerry Reuss | Bill Long | Greg Minton | Bobby Thigpen | | 711 | 746 | -35 |
| 1987-09-25 | @ CLE | 154 | L 5-7 | 72-82 | 5 | 10,453 | Don Sutton | Tom Candiotti | Doug Jones | Gary Lucas | | 716 | 753 | -37 |
| 1987-09-26 | @ CLE | 155 | L 10-11 | 72-83 | 6 | 9,320 | Willie Fraser | Rich Yett | Reggie Ritter | Gary Lucas | | 726 | 764 | -38 |
| 1987-09-27 | @ CLE | 156 | W 11-8 | 73-83 | 6 | 13,979 | Chuck Finley | Ken Schrom | Don Sutton | Ken Schrom | | 737 | 772 | -35 |
| 1987-09-29 | @ CHA | 157 | L 0-1 | 73-84 | 7 | 7,554 | Mike Witt | Floyd Bannister | Floyd Bannister | Mike Witt | Bobby Thigpen | 737 | 773 | -36 |
| 1987-09-30 | @ CHA | 158 | L 2-5 | 73-85 | 7 | 8,486 | Jerry Reuss | Richard Dotson | Richard Dotson | Jerry Reuss | Bill Long | 739 | 778 | -39 |
| 1987-10-01 | @ CHA | 159 | L 3-6 | 73-86 | 7 | 7,431 | Willie Fraser | Jack McDowell | Jack McDowell | Willie Fraser | Bobby Thigpen | 742 | 784 | -42 |
| 1987-10-02 | vs CLE | 160 | W 10-4 | 74-86 | 7 | 25,030 | Don Sutton | Rich Yett | Don Sutton | Rich Yett | | 752 | 788 | -36 |
| 1987-10-03 | vs CLE | 161 | W 12-5 | 75-86 | 7 | 22,750 | Jack Lazorko | Ken Schrom | Jack Lazorko | Ken Schrom | | 764 | 793 | -29 |
| 1987-10-04 | vs CLE | 162 | L 6-10 | 75-87 | 7 | 36,779 | Mike Witt | John Farrell | John Farrell | Mike Witt | Doug Jones | 770 | 803 | -33 |