| 1987-04-06 | @ BAL | 1 | L 1-2 | 0-1 | 6 | 51,650 | Charlie Hough | Mike Boddicker | Don Aase | Greg Harris | | 1 | 2 | -1 |
| 1987-04-08 | @ BAL | 2 | W 6-4 | 1-1 | 5 | 13,682 | Ed Correa | Scott McGregor | Dale Mohorcic | Mark Williamson | | 7 | 6 | 1 |
| 1987-04-09 | @ BAL | 3 | L 6-8 | 1-2 | 6 | 17,193 | Mike Mason | Ken Dixon | Ken Dixon | Mike Mason | | 13 | 14 | -1 |
| 1987-04-10 | vs MIL | 4 | L 8-11 | 1-3 | 6 | 42,415 | Jose Guzman | Juan Nieves | Juan Nieves | Jose Guzman | | 21 | 25 | -4 |
| 1987-04-11 | vs MIL | 5 | L 6-8 | 1-4 | 6 | 23,037 | Charlie Hough | Teddy Higuera | Teddy Higuera | Charlie Hough | Dan Plesac | 27 | 33 | -6 |
| 1987-04-12 | vs MIL | 6 | L 5-7 | 1-5 | 7 | 19,782 | Bobby Witt | Bill Wegman | Mark Clear | Scott Anderson | Chris Bosio | 32 | 40 | -8 |
| 1987-04-14 | @ BOS | 7 | L 1-4 | 1-6 | 7 | 13,740 | Ed Correa | Al Nipper | Al Nipper | Ed Correa | Calvin Schiraldi | 33 | 44 | -11 |
| 1987-04-15 | @ BOS | 8 | L 4-5 | 1-7 | 7 | 16,870 | Charlie Hough | Bruce Hurst | Bruce Hurst | Dale Mohorcic | Wes Gardner | 37 | 49 | -12 |
| 1987-04-17 | @ MIL | 9 | L 2-10 | 1-8 | 7 | 41,548 | Mike Mason | Teddy Higuera | Teddy Higuera | Mike Mason | | 39 | 59 | -20 |
| 1987-04-18 | @ MIL | 10 | L 3-4 | 1-9 | 7 | 39,715 | Bobby Witt | Bill Wegman | Bill Wegman | Bobby Witt | Dan Plesac | 42 | 63 | -21 |
| 1987-04-19 | @ MIL | 11 | L 4-6 | 1-10 | 7 | 29,357 | Jose Guzman | Mike Birkbeck | Mark Clear | Greg Harris | | 46 | 69 | -23 |
| 1987-04-21 | vs BAL | 12 | W 6-4 | 2-10 | 7 | 16,258 | Charlie Hough | Mike Flanagan | Charlie Hough | Mike Flanagan | | 52 | 73 | -21 |
| 1987-04-22 | vs BAL | 13 | L 2-3 | 2-11 | 7 | 17,306 | Ed Correa | Mike Boddicker | Dave J. Schmidt | Mitch Williams | | 54 | 76 | -22 |
| 1987-04-23 | vs BAL | 14 | W 9-4 | 3-11 | 7 | 17,553 | Mike Mason | Eric Bell | Mike Loynd | Eric Bell | Dale Mohorcic | 63 | 80 | -17 |
| 1987-04-24 | vs BOS | 15 | W 6-4 | 4-11 | 7 | 26,982 | Bobby Witt | Al Nipper | Greg Harris | Calvin Schiraldi | | 69 | 84 | -15 |
| 1987-04-25 | vs BOS | 16 | W 2-1 | 5-11 | 7 | 34,643 | Jose Guzman | Bruce Hurst | Jose Guzman | Bruce Hurst | | 71 | 85 | -14 |
| 1987-04-26 | vs BOS | 17 | W 5-3 | 6-11 | 6 | 24,470 | Charlie Hough | Roger Clemens | Mitch Williams | Calvin Schiraldi | | 76 | 88 | -12 |
| 1987-04-28 | vs NYA | 18 | W 3-1 | 7-11 | 5 | 21,201 | Ed Correa | Dennis Rasmussen | Ed Correa | Dennis Rasmussen | Dale Mohorcic | 79 | 89 | -10 |
| 1987-04-29 | vs NYA | 19 | W 8-7 | 8-11 | 5 | 19,562 | Mike Mason | Charles Hudson | Mitch Williams | Cecilio Guante | | 87 | 96 | -9 |
| 1987-05-01 | @ TOR | 20 | L 2-3 | 8-12 | 6 | 22,154 | Jose Guzman | Jimmy Key | Jeff Musselman | Mitch Williams | | 89 | 99 | -10 |
| 1987-05-02 | @ TOR | 21 | L 8-9 | 8-13 | 7 | 28,352 | Charlie Hough | Dave Stieb | Mark Eichhorn | Greg Harris | | 97 | 108 | -11 |
| 1987-05-03 | @ TOR | 22 | L 1-3 | 8-14 | 7 | 32,325 | Ed Correa | Jim Clancy | Jim Clancy | Ed Correa | Tom Henke | 98 | 111 | -13 |
| 1987-05-05 | vs CLE | 23 | W 6-5 | 9-14 | 7 | 25,955 | Mike Mason | Greg Swindell | Mitch Williams | Frank Wills | | 104 | 116 | -12 |
| 1987-05-06 | vs CLE | 24 | W 7-2 | 10-14 | 7 | 27,350 | Charlie Hough | Phil Niekro | Charlie Hough | Phil Niekro | | 111 | 118 | -7 |
| 1987-05-08 | vs TOR | 25 | L 4-7 | 10-15 | 7 | 21,832 | Jose Guzman | Jim Clancy | Jim Clancy | Jose Guzman | Mark Eichhorn | 115 | 125 | -10 |
| 1987-05-09 | vs TOR | 26 | L 4-15 | 10-16 | 7 | 28,847 | Ed Correa | Dave Stieb | Dave Stieb | Ed Correa | | 119 | 140 | -21 |
| 1987-05-10 | vs TOR | 27 | W 9-8 | 11-16 | 6 | 17,356 | Bobby Witt | Joe Johnson | Bobby Witt | Mark Eichhorn | Dale Mohorcic | 128 | 148 | -20 |
| 1987-05-11 | @ CLE | 28 | W 6-3 | 12-16 | 6 | 6,397 | Mike Mason | Phil Niekro | Ron Meridith | Phil Niekro | Mike Loynd | 134 | 151 | -17 |
| 1987-05-12 | @ CLE | 29 | W 6-1 | 13-16 | 6 | 6,370 | Charlie Hough | Steve Carlton | Charlie Hough | Steve Carlton | | 140 | 152 | -12 |
| 1987-05-13 | @ NYA | 30 | W 8-6 | 14-16 | 6 | 22,040 | Jose Guzman | Tommy John | Jose Guzman | Tommy John | Dale Mohorcic | 148 | 158 | -10 |
| 1987-05-14 | @ NYA | 31 | L 1-9 | 14-17 | 6 | 22,635 | Ed Correa | Dennis Rasmussen | Dennis Rasmussen | Ed Correa | | 149 | 167 | -18 |
| 1987-05-15 | @ CHA | 32 | L 0-5 | 14-18 | 6 | 11,969 | Bobby Witt | Richard Dotson | Richard Dotson | Bobby Witt | | 149 | 172 | -23 |
| 1987-05-16 | @ CHA | 33 | W 7-2 | 15-18 | 6 | 24,692 | Mike Loynd | Floyd Bannister | Dale Mohorcic | Jim Winn | | 156 | 174 | -18 |
| 1987-05-17 | @ CHA | 34 | L 5-8 | 15-19 | 6 | 16,099 | Charlie Hough | Bill Long | Joel McKeon | Greg Harris | Bob James | 161 | 182 | -21 |
| 1987-05-18 | vs DET | 35 | L 3-6 | 15-20 | 6 | 26,503 | Jose Guzman | Jeff Robinson | Jeff Robinson | Jose Guzman | Mark Thurmond | 164 | 188 | -24 |
| 1987-05-19 | vs DET | 36 | W 10-8 | 16-20 | 6 | 17,484 | Ed Correa | Frank Tanana | Dale Mohorcic | Eric King | | 174 | 196 | -22 |
| 1987-05-20 | vs DET | 37 | L 4-6 | 16-21 | 6 | 16,820 | Bobby Witt | Dan Petry | Dan Petry | Bobby Witt | Eric King | 178 | 202 | -24 |
| 1987-05-22 | vs KCA | 38 | L 1-8 | 16-22 | 6 | 28,609 | Mike Loynd | Charlie Leibrandt | Charlie Leibrandt | Mike Loynd | | 179 | 210 | -31 |
| 1987-05-23 | vs KCA | 39 | W 6-4 | 17-22 | 6 | 35,133 | Charlie Hough | Buddy Black | Charlie Hough | Buddy Black | | 185 | 214 | -29 |
| 1987-05-24 | vs KCA | 40 | L 2-5 | 17-23 | 7 | 38,952 | Jose Guzman | Mark Gubicza | Jerry Gleaton | Jose Guzman | Dan Quisenberry | 187 | 219 | -32 |
| 1987-05-25 | @ DET | 41 | L 5-8 | 17-24 | 7 | 13,824 | Ed Correa | Frank Tanana | Frank Tanana | Ed Correa | Mike Henneman | 192 | 227 | -35 |
| 1987-05-26 | @ DET | 42 | L 7-8 | 17-25 | 7 | 11,234 | Bob Malloy | Dan Petry | Mike Henneman | Dale Mohorcic | | 199 | 235 | -36 |
| 1987-05-27 | @ DET | 43 | L 3-4 | 17-26 | 7 | 12,696 | Mike Loynd | Jack Morris | Jack Morris | Mike Loynd | Mark Thurmond | 202 | 239 | -37 |
| 1987-05-29 | @ KCA | 44 | W 16-5 | 18-26 | 7 | 31,849 | Charlie Hough | Mark Gubicza | Charlie Hough | Mark Gubicza | | 218 | 244 | -26 |
| 1987-05-30 | @ KCA | 45 | L 7-12 | 18-27 | 7 | 38,513 | Jose Guzman | Bret Saberhagen | Bret Saberhagen | Jose Guzman | Steve Farr | 225 | 256 | -31 |
| 1987-05-31 | @ KCA | 46 | W 3-2 | 19-27 | 7 | 36,349 | Ed Correa | Danny Jackson | Dale Mohorcic | Jerry Gleaton | | 228 | 258 | -30 |
| 1987-06-01 | vs CHA | 47 | W 11-9 | 20-27 | 7 | 26,658 | Bob Malloy | Richard Dotson | Dale Mohorcic | Joel Davis | | 239 | 267 | -28 |
| 1987-06-02 | vs CHA | 48 | L 5-15 | 20-28 | 7 | 11,989 | Charlie Hough | Bill Long | Bill Long | Charlie Hough | | 244 | 282 | -38 |
| 1987-06-03 | vs CHA | 49 | W 14-3 | 21-28 | 6 | 19,487 | Mike Loynd | Floyd Bannister | Jose Guzman | Floyd Bannister | | 258 | 285 | -27 |
| 1987-06-05 | @ MIN | 50 | W 15-9 | 22-28 | 6 | 16,092 | Greg Harris | Bert Blyleven | Greg Harris | Bert Blyleven | | 273 | 294 | -21 |
| 1987-06-06 | @ MIN | 51 | L 2-3 | 22-29 | 6 | 24,992 | Charlie Hough | Frank Viola | Keith Atherton | Mitch Williams | | 275 | 297 | -22 |
| 1987-06-07 | @ MIN | 52 | L 4-7 | 22-30 | 7 | 15,795 | Ed Correa | Juan Berenguer | Keith Atherton | Jeff Russell | | 279 | 304 | -25 |
| 1987-06-08 | @ SEA | 53 | L 0-6 | 22-31 | 7 | 13,123 | Mike Jeffcoat | Mark Langston | Mark Langston | Mike Jeffcoat | | 279 | 310 | -31 |
| 1987-06-09 | @ SEA | 54 | W 3-0 | 23-31 | 6 | 6,729 | Jose Guzman | Mike Morgan | Jose Guzman | Mike Morgan | Dale Mohorcic | 282 | 310 | -28 |
| 1987-06-10 | @ SEA | 55 | W 9-5 | 24-31 | 6 | 7,449 | Charlie Hough | Lee Guetterman | Mitch Williams | Bill Wilkinson | Dale Mohorcic | 291 | 315 | -24 |
| 1987-06-12 | vs OAK | 56 | L 1-6 | 24-32 | 6 | 20,393 | Greg Harris | Dave Stewart | Dave Stewart | Greg Harris | | 292 | 321 | -29 |
| 1987-06-13 | vs OAK | 57 | L 8-10 | 24-33 | 6 | 33,882 | Ed Correa | Moose Haas | Steve Ontiveros | Paul Kilgus | Jay Howell | 300 | 331 | -31 |
| 1987-06-14 | vs OAK | 58 | W 5-1 | 25-33 | 6 | 32,743 | Charlie Hough | Eric Plunk | Charlie Hough | Eric Plunk | | 305 | 332 | -27 |
| 1987-06-15 | @ CAL | 59 | W 9-7 | 26-33 | 6 | 23,064 | Mike Jeffcoat | Jack Lazorko | Jeff Russell | Chuck Finley | Dale Mohorcic | 314 | 339 | -25 |
| 1987-06-16 | @ CAL | 60 | W 5-4 | 27-33 | 6 | 25,660 | Jose Guzman | John Candelaria | Jose Guzman | John Candelaria | Dale Mohorcic | 319 | 343 | -24 |
| 1987-06-17 | @ CAL | 61 | L 1-6 | 27-34 | 6 | 23,829 | Greg Harris | Mike Witt | Mike Witt | Greg Harris | | 320 | 349 | -29 |
| 1987-06-19 | @ OAK | 62 | W 4-2 | 28-34 | 5 | 11,717 | Charlie Hough | Moose Haas | Charlie Hough | Moose Haas | Dale Mohorcic | 324 | 351 | -27 |
| 1987-06-20 | @ OAK | 63 | W 7-6 | 29-34 | 5 | 21,937 | Bobby Witt | Curt Young | Bobby Witt | Curt Young | Mitch Williams | 331 | 357 | -26 |
| 1987-06-21 | @ OAK | 64 | L 3-7 | 30-35 | 5 | 0 | Jose Guzman | Dave Stewart | Dave Stewart | Jose Guzman | Dennis Eckersley | 334 | 364 | -30 |
| 1987-06-21 | @ OAK | 65 | W 13-3 | 30-35 | 5 | 28,395 | Ed Correa | Eric Plunk | Ed Correa | Eric Plunk | Jeff Russell | 347 | 367 | -20 |
| 1987-06-22 | vs CAL | 66 | L 3-7 | 30-36 | 6 | 25,118 | Greg Harris | Mike Witt | DeWayne Buice | Greg Harris | Greg Minton | 350 | 374 | -24 |
| 1987-06-23 | vs CAL | 67 | L 6-8 | 30-37 | 6 | 32,996 | Charlie Hough | Willie Fraser | Willie Fraser | Charlie Hough | Greg Minton | 356 | 382 | -26 |
| 1987-06-24 | vs CAL | 68 | L 1-4 | 30-38 | 6 | 17,218 | Mike Loynd | Don Sutton | Don Sutton | Mike Loynd | DeWayne Buice | 357 | 386 | -29 |
| 1987-06-26 | vs MIN | 69 | W 1-0 | 31-38 | 6 | 20,605 | Bobby Witt | Frank Viola | Bobby Witt | Frank Viola | Dale Mohorcic | 358 | 386 | -28 |
| 1987-06-27 | vs MIN | 70 | W 11-6 | 33-38 | 6 | 0 | Ed Correa | Joe Niekro | Ed Correa | George Frazier | Jeff Russell | 369 | 392 | -23 |
| 1987-06-27 | vs MIN | 71 | W 7-2 | 33-38 | 6 | 35,677 | Charlie Hough | Juan Berenguer | Charlie Hough | Keith Atherton | | 376 | 394 | -18 |
| 1987-06-28 | vs MIN | 72 | W 6-3 | 34-38 | 6 | 17,477 | Jose Guzman | Mike Smithson | Jose Guzman | Mike Smithson | Dale Mohorcic | 382 | 397 | -15 |
| 1987-06-29 | vs SEA | 73 | W 4-3 | 35-38 | 6 | 19,265 | Greg Harris | Jerry Reed | Mitch Williams | Stan Clarke | | 386 | 400 | -14 |
| 1987-06-30 | vs SEA | 74 | L 2-5 | 35-39 | 6 | 21,504 | Mike Loynd | Mark Langston | Mark Langston | Mike Loynd | | 388 | 405 | -17 |
| 1987-07-01 | vs SEA | 75 | W 7-3 | 36-39 | 6 | 22,569 | Charlie Hough | Mike Morgan | Charlie Hough | Mike Morgan | | 395 | 408 | -13 |
| 1987-07-03 | @ NYA | 76 | W 9-0 | 37-40 | 6 | 0 | Bobby Witt | Bob Tewksbury | Bobby Witt | Bob Tewksbury | | 404 | 408 | -4 |
| 1987-07-03 | @ NYA | 77 | L 1-3 | 37-40 | 6 | 43,856 | Jose Guzman | Rick Rhoden | Rick Rhoden | Jose Guzman | Dave Righetti | 405 | 411 | -6 |
| 1987-07-04 | @ NYA | 78 | L 3-4 | 37-41 | 6 | 33,214 | Greg Harris | Dennis Rasmussen | Dennis Rasmussen | Greg Harris | Dave Righetti | 408 | 415 | -7 |
| 1987-07-05 | @ NYA | 79 | W 10-4 | 38-41 | 6 | 34,080 | Ed Correa | Rich Bordi | Jeff Russell | Rich Bordi | | 418 | 419 | -1 |
| 1987-07-06 | @ TOR | 80 | L 4-6 | 38-42 | 6 | 28,264 | Charlie Hough | Jimmy Key | Jimmy Key | Charlie Hough | Tom Henke | 422 | 425 | -3 |
| 1987-07-07 | @ TOR | 81 | L 2-6 | 38-43 | 6 | 28,013 | Mike Loynd | Jim Clancy | Jim Clancy | Mike Loynd | Tom Henke | 424 | 431 | -7 |
| 1987-07-08 | @ TOR | 82 | L 2-5 | 38-44 | 6 | 30,341 | Bobby Witt | John Cerutti | Jeff Musselman | Bobby Witt | Tom Henke | 426 | 436 | -10 |
| 1987-07-09 | vs CLE | 83 | L 4-10 | 38-45 | 6 | 20,731 | Jose Guzman | Scott Bailes | Doug Jones | Jose Guzman | | 430 | 446 | -16 |
| 1987-07-10 | vs CLE | 84 | W 10-4 | 39-45 | 6 | 18,112 | Greg Harris | Phil Niekro | Greg Harris | Phil Niekro | | 440 | 450 | -10 |
| 1987-07-11 | vs CLE | 85 | W 6-2 | 40-45 | 6 | 36,392 | Charlie Hough | Steve Carlton | Charlie Hough | Steve Carlton | Jeff Russell | 446 | 452 | -6 |
| 1987-07-12 | vs CLE | 86 | W 7-6 | 41-45 | 6 | 14,809 | Mike Loynd | Ken Schrom | Jose Guzman | Doug Jones | Dale Mohorcic | 453 | 458 | -5 |
| 1987-07-16 | vs NYA | 87 | L 3-12 | 41-46 | 6 | 24,459 | Charlie Hough | Ron Guidry | Ron Guidry | Charlie Hough | | 456 | 470 | -14 |
| 1987-07-17 | vs NYA | 88 | L 4-8 | 41-47 | 6 | 33,977 | Bobby Witt | Rick Rhoden | Rick Rhoden | Bobby Witt | | 460 | 478 | -18 |
| 1987-07-18 | vs NYA | 89 | W 7-2 | 42-47 | 6 | 41,871 | Jose Guzman | Dennis Rasmussen | Jose Guzman | Charles Hudson | | 467 | 480 | -13 |
| 1987-07-19 | vs NYA | 90 | W 20-3 | 43-47 | 6 | 30,875 | Greg Harris | Steve Trout | Greg Harris | Steve Trout | | 487 | 483 | 4 |
| 1987-07-20 | vs TOR | 91 | L 3-5 | 43-48 | 6 | 27,501 | Charlie Hough | John Cerutti | John Cerutti | Charlie Hough | Tom Henke | 490 | 488 | 2 |
| 1987-07-21 | vs TOR | 92 | W 6-4 | 44-48 | 6 | 13,791 | Paul Kilgus | Jimmy Key | Dale Mohorcic | Jeff Musselman | | 496 | 492 | 4 |
| 1987-07-22 | vs TOR | 93 | W 5-3 | 45-48 | 6 | 16,380 | Bobby Witt | Jim Clancy | Jeff Russell | Gary Lavelle | Dale Mohorcic | 501 | 495 | 6 |
| 1987-07-23 | @ CLE | 94 | L 2-4 | 45-49 | 6 | 7,888 | Jose Guzman | Tom Candiotti | Tom Candiotti | Jose Guzman | | 503 | 499 | 4 |
| 1987-07-24 | @ CLE | 95 | W 6-3 | 46-49 | 6 | 10,664 | Greg Harris | Steve Carlton | Jeff Russell | Steve Carlton | Dale Mohorcic | 509 | 502 | 7 |
| 1987-07-25 | @ CLE | 96 | W 7-3 | 47-49 | 5 | 15,170 | Charlie Hough | Phil Niekro | Charlie Hough | Phil Niekro | Dale Mohorcic | 516 | 505 | 11 |
| 1987-07-26 | @ CLE | 97 | W 11-3 | 48-49 | 5 | 25,460 | Paul Kilgus | Scott Bailes | Paul Kilgus | Scott Bailes | | 527 | 508 | 19 |
| 1987-07-27 | vs MIL | 98 | W 5-4 | 49-49 | 4 | 16,621 | Bobby Witt | Bill Wegman | Mitch Williams | Dan Plesac | | 532 | 512 | 20 |
| 1987-07-28 | vs MIL | 99 | L 2-9 | 49-50 | 5 | 17,899 | Jose Guzman | Chris Bosio | Chris Bosio | Jose Guzman | Mark Clear | 534 | 521 | 13 |
| 1987-07-29 | vs MIL | 100 | L 8-9 | 49-51 | 5 | 17,157 | Greg Harris | Juan Nieves | Dan Plesac | Paul Kilgus | | 542 | 530 | 12 |
| 1987-07-31 | vs BAL | 101 | L 4-8 | 49-52 | 4 | 28,228 | Charlie Hough | Dave J. Schmidt | John Habyan | Charlie Hough | Tom Niedenfuer | 546 | 538 | 8 |
| 1987-08-01 | vs BAL | 102 | L 1-7 | 49-53 | 5 | 36,748 | Paul Kilgus | Ken Dixon | Ken Dixon | Paul Kilgus | Mike Griffin | 547 | 545 | 2 |
| 1987-08-02 | vs BAL | 103 | W 5-2 | 50-53 | 5 | 15,597 | Bobby Witt | Mike Boddicker | Bobby Witt | Mike Boddicker | | 552 | 547 | 5 |
| 1987-08-03 | vs BOS | 104 | L 2-11 | 50-54 | 6 | 21,928 | Jose Guzman | Bruce Hurst | Bruce Hurst | Jose Guzman | | 554 | 558 | -4 |
| 1987-08-04 | vs BOS | 105 | L 6-8 | 50-55 | 6 | 17,377 | Greg Harris | Rob Woodward | Calvin Schiraldi | Dale Mohorcic | | 560 | 566 | -6 |
| 1987-08-05 | vs BOS | 106 | W 9-8 | 51-55 | 5 | 19,843 | Charlie Hough | Roger Clemens | Jose Guzman | Joe Sambito | | 569 | 574 | -5 |
| 1987-08-07 | @ BAL | 107 | L 2-9 | 51-56 | 6 | 33,657 | Paul Kilgus | Ken Dixon | Ken Dixon | Paul Kilgus | | 571 | 583 | -12 |
| 1987-08-08 | @ BAL | 108 | W 11-5 | 52-56 | 6 | 34,883 | Bobby Witt | Mike Boddicker | Bobby Witt | Mike Boddicker | Mitch Williams | 582 | 588 | -6 |
| 1987-08-09 | @ BAL | 109 | L 4-5 | 52-57 | 6 | 22,525 | Charlie Hough | Eric Bell | John Habyan | Charlie Hough | | 586 | 593 | -7 |
| 1987-08-10 | @ MIL | 110 | L 3-4 | 52-58 | 6 | 21,257 | Jose Guzman | Teddy Higuera | Jay Aldrich | Jeff Russell | | 589 | 597 | -8 |
| 1987-08-11 | @ MIL | 111 | W 7-1 | 53-58 | 6 | 17,502 | Greg Harris | Mark Knudson | Greg Harris | Mark Knudson | | 596 | 598 | -2 |
| 1987-08-12 | @ MIL | 112 | W 12-3 | 54-58 | 6 | 21,609 | Paul Kilgus | Ray Burris | Paul Kilgus | Ray Burris | | 608 | 601 | 7 |
| 1987-08-14 | @ BOS | 113 | L 3-9 | 55-59 | 6 | 0 | Bobby Witt | Bruce Hurst | Bruce Hurst | Steve Howe | | 611 | 610 | 1 |
| 1987-08-14 | @ BOS | 114 | W 9-4 | 55-59 | 6 | 33,840 | Charlie Hough | Al Nipper | Charlie Hough | Al Nipper | | 620 | 614 | 6 |
| 1987-08-15 | @ BOS | 115 | L 6-7 | 55-60 | 6 | 31,189 | Jose Guzman | Roger Clemens | Wes Gardner | Steve Howe | | 626 | 621 | 5 |
| 1987-08-16 | @ BOS | 116 | L 2-12 | 55-61 | 6 | 31,438 | Greg Harris | Bob Stanley | Bob Stanley | Greg Harris | | 628 | 633 | -5 |
| 1987-08-17 | vs KCA | 117 | L 6-7 | 55-62 | 6 | 24,101 | Paul Kilgus | Charlie Leibrandt | John Davis | Jeff Russell | | 634 | 640 | -6 |
| 1987-08-18 | vs KCA | 118 | W 3-1 | 56-62 | 5 | 23,070 | Charlie Hough | Mark Gubicza | Charlie Hough | Mark Gubicza | | 637 | 641 | -4 |
| 1987-08-19 | vs KCA | 119 | L 6-11 | 56-63 | 5 | 24,588 | Bobby Witt | Buddy Black | Bob Stoddard | Bobby Witt | John Davis | 643 | 652 | -9 |
| 1987-08-20 | vs CHA | 120 | W 5-1 | 57-63 | 5 | 11,213 | Jose Guzman | Richard Dotson | Jose Guzman | Richard Dotson | | 648 | 653 | -5 |
| 1987-08-21 | vs CHA | 121 | L 1-5 | 57-64 | 6 | 26,924 | Paul Kilgus | Bill Long | Bill Long | Paul Kilgus | | 649 | 658 | -9 |
| 1987-08-22 | vs CHA | 122 | W 8-6 | 58-64 | 6 | 29,695 | Charlie Hough | Dave LaPoint | Charlie Hough | Dave LaPoint | Mitch Williams | 657 | 664 | -7 |
| 1987-08-23 | vs CHA | 123 | L 1-8 | 58-65 | 6 | 14,120 | Jeff Russell | Floyd Bannister | Floyd Bannister | Jeff Russell | | 658 | 672 | -14 |
| 1987-08-24 | @ KCA | 124 | W 4-2 | 59-65 | 5 | 27,042 | Bobby Witt | Mark Gubicza | Bobby Witt | Mark Gubicza | Mitch Williams | 662 | 674 | -12 |
| 1987-08-25 | @ KCA | 125 | W 15-8 | 60-65 | 5 | 21,037 | Jose Guzman | Buddy Black | Steve Howe | Bob Stoddard | | 677 | 682 | -5 |
| 1987-08-26 | @ KCA | 126 | L 0-3 | 60-66 | 5 | 22,398 | Charlie Hough | Danny Jackson | Danny Jackson | Charlie Hough | | 677 | 685 | -8 |
| 1987-08-27 | @ KCA | 127 | L 2-3 | 60-67 | 5 | 28,044 | Paul Kilgus | Bret Saberhagen | John Davis | Dale Mohorcic | | 679 | 688 | -9 |
| 1987-08-28 | @ DET | 128 | W 5-3 | 61-67 | 5 | 32,362 | Jeff Russell | Jack Morris | Mitch Williams | Jack Morris | Dale Mohorcic | 684 | 691 | -7 |
| 1987-08-29 | @ DET | 129 | L 1-4 | 61-68 | 6 | 41,604 | Bobby Witt | Walt Terrell | Walt Terrell | Bobby Witt | | 685 | 695 | -10 |
| 1987-08-30 | @ DET | 130 | L 0-7 | 61-69 | 6 | 38,641 | Charlie Hough | Doyle Alexander | Doyle Alexander | Charlie Hough | | 685 | 702 | -17 |
| 1987-09-01 | @ CHA | 131 | W 6-4 | 62-69 | 5 | 7,866 | Jose Guzman | Bill Long | Jose Guzman | Bill Long | Mitch Williams | 691 | 706 | -15 |
| 1987-09-02 | @ CHA | 132 | L 0-5 | 62-70 | 6 | 9,293 | Paul Kilgus | Dave LaPoint | Dave LaPoint | Paul Kilgus | | 691 | 711 | -20 |
| 1987-09-03 | @ CHA | 133 | L 2-5 | 62-71 | 6 | 8,262 | Bobby Witt | Floyd Bannister | Floyd Bannister | Bobby Witt | Bobby Thigpen | 693 | 716 | -23 |
| 1987-09-04 | vs DET | 134 | L 2-11 | 62-72 | 6 | 16,095 | Charlie Hough | Doyle Alexander | Doyle Alexander | Charlie Hough | | 695 | 727 | -32 |
| 1987-09-05 | vs DET | 135 | W 8-7 | 63-72 | 6 | 26,058 | Greg Harris | Frank Tanana | Steve Howe | Guillermo Hernandez | | 703 | 734 | -31 |
| 1987-09-06 | vs DET | 136 | W 9-3 | 64-72 | 5 | 22,374 | Jose Guzman | Jeff Robinson | Jose Guzman | Jeff Robinson | | 712 | 737 | -25 |
| 1987-09-07 | @ OAK | 137 | L 1-2 | 64-73 | 6 | 27,691 | Paul Kilgus | Dave Stewart | Dave Stewart | Mitch Williams | | 713 | 739 | -26 |
| 1987-09-08 | @ OAK | 138 | W 12-1 | 65-73 | 6 | 12,287 | Charlie Hough | Gene Nelson | Charlie Hough | Gene Nelson | | 725 | 740 | -15 |
| 1987-09-09 | @ OAK | 139 | L 7-11 | 65-74 | 6 | 10,143 | Bobby Witt | Storm Davis | Greg Cadaret | Bobby Witt | | 732 | 751 | -19 |
| 1987-09-10 | @ CAL | 140 | L 7-8 | 65-75 | 6 | 22,589 | Greg Harris | Don Sutton | DeWayne Buice | Steve Howe | | 739 | 759 | -20 |
| 1987-09-11 | @ CAL | 141 | W 7-2 | 66-75 | 6 | 28,693 | Jose Guzman | John Candelaria | Jose Guzman | John Candelaria | | 746 | 761 | -15 |
| 1987-09-12 | @ CAL | 142 | W 4-3 | 67-75 | 6 | 29,551 | Charlie Hough | Mike Witt | Charlie Hough | Mike Witt | Steve Howe | 750 | 764 | -14 |
| 1987-09-13 | @ CAL | 143 | W 8-2 | 68-75 | 4 | 34,766 | Paul Kilgus | Jerry Reuss | Jeff Russell | Jerry Reuss | Mitch Williams | 758 | 766 | -8 |
| 1987-09-14 | vs OAK | 144 | W 2-1 | 69-75 | 4 | 11,888 | Bobby Witt | Storm Davis | Dale Mohorcic | Steve Ontiveros | | 760 | 767 | -7 |
| 1987-09-15 | vs OAK | 145 | L 5-6 | 69-76 | 4 | 9,533 | Greg Harris | Curt Young | Eric Plunk | Dale Mohorcic | Dennis Eckersley | 765 | 773 | -8 |
| 1987-09-16 | vs OAK | 146 | W 4-1 | 70-76 | 4 | 10,953 | Charlie Hough | Dave Stewart | Charlie Hough | Dave Stewart | | 769 | 774 | -5 |
| 1987-09-18 | vs CAL | 147 | W 5-1 | 71-76 | 4 | 12,243 | Jose Guzman | Jerry Reuss | Jose Guzman | Jerry Reuss | | 774 | 775 | -1 |
| 1987-09-19 | vs CAL | 148 | W 4-3 | 72-76 | 4 | 27,343 | Bobby Witt | Don Sutton | Mitch Williams | DeWayne Buice | | 778 | 778 | 0 |
| 1987-09-20 | vs CAL | 149 | W 2-1 | 73-76 | 4 | 11,496 | Charlie Hough | Willie Fraser | Steve Howe | Greg Minton | | 780 | 779 | 1 |
| 1987-09-22 | @ MIN | 150 | L 4-6 | 73-77 | 4 | 18,294 | Greg Harris | Joe Niekro | Joe Niekro | Greg Harris | Jeff Reardon | 784 | 785 | -1 |
| 1987-09-23 | @ MIN | 151 | L 2-4 | 73-78 | 4 | 20,640 | Jose Guzman | Bert Blyleven | Juan Berenguer | Jose Guzman | Jeff Reardon | 786 | 789 | -3 |
| 1987-09-24 | @ MIN | 152 | L 0-4 | 73-79 | 4 | 23,496 | Charlie Hough | Frank Viola | Frank Viola | Charlie Hough | | 786 | 793 | -7 |
| 1987-09-25 | @ SEA | 153 | L 3-12 | 73-80 | 4 | 7,246 | Bobby Witt | Mike Morgan | Mike Morgan | Bobby Witt | | 789 | 805 | -16 |
| 1987-09-26 | @ SEA | 154 | L 1-2 | 73-81 | 4 | 30,977 | Paul Kilgus | Mike Moore | Mike Moore | Paul Kilgus | Bill Wilkinson | 790 | 807 | -17 |
| 1987-09-27 | @ SEA | 155 | L 3-5 | 73-82 | 5 | 9,032 | Greg Harris | Mike Campbell | Mike Trujillo | Mitch Williams | Ed Nunez | 793 | 812 | -19 |
| 1987-09-28 | vs MIN | 156 | L 3-5 | 73-83 | 5 | 9,986 | Jose Guzman | Joe Niekro | Juan Berenguer | Jose Guzman | Jeff Reardon | 796 | 817 | -21 |
| 1987-09-29 | vs MIN | 157 | W 7-5 | 74-83 | 5 | 10,328 | Charlie Hough | Dan Schatzeder | Charlie Hough | Keith Atherton | | 803 | 822 | -19 |
| 1987-09-30 | vs MIN | 158 | W 2-1 | 75-83 | 4 | 9,309 | Bobby Witt | Les Straker | Bobby Witt | Les Straker | | 805 | 823 | -18 |
| 1987-10-01 | vs SEA | 159 | L 6-8 | 75-84 | 6 | 7,890 | Mitch Williams | Mike Moore | Mike Moore | Mitch Williams | Bill Wilkinson | 811 | 831 | -20 |
| 1987-10-02 | vs SEA | 160 | L 4-5 | 75-85 | 6 | 11,711 | Greg Harris | Clay Parker | Dennis Powell | Dale Mohorcic | Bill Wilkinson | 815 | 836 | -21 |
| 1987-10-03 | vs SEA | 161 | L 4-6 | 75-86 | 6 | 19,696 | Jose Guzman | Lee Guetterman | Lee Guetterman | Jose Guzman | Bill Wilkinson | 819 | 842 | -23 |
| 1987-10-04 | vs SEA | 162 | L 4-7 | 75-87 | 6 | 17,208 | Charlie Hough | Mark Langston | Mark Langston | Charlie Hough | Jerry Reed | 823 | 849 | -26 |