| 1987-04-07 | @ CAL | 1 | L 1-7 | 0-1 | 6 | 37,097 | Mark Langston | Mike Witt | Mike Witt | Mark Langston | | 1 | 7 | -6 |
| 1987-04-08 | @ CAL | 2 | L 1-7 | 0-2 | 7 | 24,703 | Mike Moore | John Candelaria | John Candelaria | Mike Moore | | 2 | 14 | -12 |
| 1987-04-09 | @ CAL | 3 | W 7-2 | 1-2 | 5 | 24,244 | Scott Bankhead | Don Sutton | Scott Bankhead | Don Sutton | Steve Shields | 9 | 16 | -7 |
| 1987-04-10 | vs MIN | 4 | L 1-8 | 1-3 | 5 | 38,122 | Mike Morgan | Mike Smithson | Mike Smithson | Mike Morgan | | 10 | 24 | -14 |
| 1987-04-11 | vs MIN | 5 | W 6-5 | 2-3 | 5 | 26,312 | Mike Trujillo | Les Straker | Ed Nunez | Jeff Reardon | | 16 | 29 | -13 |
| 1987-04-12 | vs MIN | 6 | L 5-8 | 2-4 | 5 | 9,358 | Mark Langston | Bert Blyleven | Bert Blyleven | Mark Langston | Juan Berenguer | 21 | 37 | -16 |
| 1987-04-13 | vs CAL | 7 | L 3-5 | 2-5 | 6 | 11,834 | Mike Moore | John Candelaria | Donnie Moore | Ed Nunez | | 24 | 42 | -18 |
| 1987-04-14 | vs CAL | 8 | W 6-4 | 3-5 | 4 | 7,301 | Scott Bankhead | Don Sutton | Scott Bankhead | Don Sutton | Ed Nunez | 30 | 46 | -16 |
| 1987-04-15 | vs CAL | 9 | L 0-4 | 3-6 | 5 | 8,333 | Mike Morgan | Kirk McCaskill | Kirk McCaskill | Mike Morgan | | 30 | 50 | -20 |
| 1987-04-16 | vs OAK | 10 | W 6-5 | 4-6 | 4 | 7,349 | Mike Trujillo | Jose Rijo | Mike Trujillo | Jose Rijo | Ed Nunez | 36 | 55 | -19 |
| 1987-04-17 | vs OAK | 11 | W 4-2 | 5-6 | 4 | 12,168 | Mark Langston | Curt Young | Mark Langston | Curt Young | | 40 | 57 | -17 |
| 1987-04-18 | vs OAK | 12 | L 5-7 | 5-7 | 4 | 19,383 | Mike Moore | Eric Plunk | Jay Howell | Mike Moore | | 45 | 64 | -19 |
| 1987-04-19 | vs OAK | 13 | W 8-1 | 6-7 | 3 | 8,036 | Scott Bankhead | Chris Codiroli | Scott Bankhead | Chris Codiroli | | 53 | 65 | -12 |
| 1987-04-20 | @ MIN | 14 | L 5-13 | 6-8 | 4 | 11,927 | Mike Morgan | Mike Smithson | Mike Smithson | Mike Morgan | | 58 | 78 | -20 |
| 1987-04-21 | @ MIN | 15 | L 1-6 | 6-9 | 4 | 10,776 | Mike Trujillo | Les Straker | Les Straker | Mike Trujillo | | 59 | 84 | -25 |
| 1987-04-22 | @ MIN | 16 | W 4-3 | 7-9 | 3 | 11,247 | Mark Langston | Bert Blyleven | Mark Langston | George Frazier | | 63 | 87 | -24 |
| 1987-04-24 | @ OAK | 17 | W 6-3 | 8-9 | 3 | 11,152 | Mike Moore | Eric Plunk | Mike Moore | Bill Krueger | | 69 | 90 | -21 |
| 1987-04-25 | @ OAK | 18 | L 3-7 | 8-10 | 3 | 15,720 | Scott Bankhead | Dave Stewart | Dave Stewart | Scott Bankhead | Dennis Eckersley | 72 | 97 | -25 |
| 1987-04-26 | @ OAK | 19 | W 8-5 | 9-10 | 3 | 16,603 | Mike Trujillo | Jose Rijo | Mike Trujillo | Jose Rijo | Ed Nunez | 80 | 102 | -22 |
| 1987-04-27 | vs DET | 20 | W 5-2 | 10-10 | 3 | 8,492 | Mark Langston | Frank Tanana | Mark Langston | Eric King | Ed Nunez | 85 | 104 | -19 |
| 1987-04-28 | vs DET | 21 | W 6-4 | 11-10 | 3 | 7,393 | Mike Morgan | Jeff Robinson | Mike Morgan | Jeff Robinson | Ed Nunez | 91 | 108 | -17 |
| 1987-04-29 | vs BOS | 22 | L 5-11 | 11-11 | 3 | 10,378 | Mike Moore | Al Nipper | Al Nipper | Mike Moore | | 96 | 119 | -23 |
| 1987-04-30 | vs BOS | 23 | W 11-2 | 12-11 | 2 | 9,985 | Scott Bankhead | Bruce Hurst | Scott Bankhead | Bruce Hurst | | 107 | 121 | -14 |
| 1987-05-01 | vs MIL | 24 | L 8-10 | 12-12 | 2 | 13,689 | Mike Trujillo | Mike Birkbeck | Paul Mirabella | Bill Wilkinson | Dan Plesac | 115 | 131 | -16 |
| 1987-05-02 | vs MIL | 25 | L 4-6 | 12-13 | 3 | 23,701 | Mark Langston | Juan Nieves | Mark Clear | Mark Langston | Dan Plesac | 119 | 137 | -18 |
| 1987-05-03 | vs MIL | 26 | W 7-3 | 13-13 | 4 | 12,632 | Mike Morgan | Teddy Higuera | Mike Morgan | Teddy Higuera | | 126 | 140 | -14 |
| 1987-05-05 | @ DET | 27 | W 7-5 | 14-13 | 4 | 10,918 | Mike Moore | Jack Morris | Stan Clarke | Jeff Robinson | Ed Nunez | 133 | 145 | -12 |
| 1987-05-06 | @ DET | 28 | L 5-7 | 14-14 | 4 | 13,718 | Scott Bankhead | Walt Terrell | Walt Terrell | Scott Bankhead | Mark Thurmond | 138 | 152 | -14 |
| 1987-05-08 | @ MIL | 29 | W 4-3 | 15-14 | 4 | 20,512 | Mark Langston | Teddy Higuera | Stan Clarke | Chris Bosio | Bill Wilkinson | 142 | 155 | -13 |
| 1987-05-09 | @ MIL | 30 | W 8-2 | 16-14 | 4 | 43,502 | Mike Morgan | Juan Nieves | Mike Morgan | Juan Nieves | | 150 | 157 | -7 |
| 1987-05-10 | @ MIL | 31 | W 5-1 | 17-14 | 2 | 25,496 | Mike Moore | Bill Wegman | Mike Moore | Bill Wegman | | 155 | 158 | -3 |
| 1987-05-11 | @ BOS | 32 | W 4-3 | 18-14 | 1 | 21,410 | Scott Bankhead | Roger Clemens | Scott Bankhead | Roger Clemens | Ed Nunez | 159 | 161 | -2 |
| 1987-05-12 | @ BOS | 33 | L 2-3 | 18-15 | 2 | 19,193 | Mike Trujillo | Jeff Sellers | Jeff Sellers | Mike Trujillo | Wes Gardner | 161 | 164 | -3 |
| 1987-05-13 | @ BOS | 34 | W 5-4 | 19-15 | 2 | 20,270 | Mark Langston | Al Nipper | Mark Langston | Joe Sambito | Steve Shields | 166 | 168 | -2 |
| 1987-05-15 | vs NYA | 35 | L 3-7 | 19-16 | 2 | 27,923 | Mike Morgan | Charles Hudson | Charles Hudson | Mike Morgan | Dave Righetti | 169 | 175 | -6 |
| 1987-05-16 | vs NYA | 36 | W 10-8 | 20-16 | 2 | 42,570 | Scott Bankhead | Rick Rhoden | Steve Shields | Cecilio Guante | | 179 | 183 | -4 |
| 1987-05-17 | vs NYA | 37 | L 3-8 | 20-17 | 2 | 32,832 | Mike Moore | Joe Niekro | Joe Niekro | Mike Moore | Dave Righetti | 182 | 191 | -9 |
| 1987-05-18 | vs BAL | 38 | L 0-6 | 20-18 | 2 | 17,114 | Mark Langston | Mike Boddicker | Mike Boddicker | Mark Langston | | 182 | 197 | -15 |
| 1987-05-19 | vs BAL | 39 | L 4-15 | 20-19 | 2 | 7,109 | Mike Trujillo | Jeff Ballard | Jeff Ballard | Mike Trujillo | | 186 | 212 | -26 |
| 1987-05-20 | vs BAL | 40 | W 6-2 | 21-19 | 2 | 9,160 | Mike Morgan | John Habyan | Mike Morgan | Ken Dixon | | 192 | 214 | -22 |
| 1987-05-22 | vs TOR | 41 | L 5-7 | 21-20 | 2 | 10,012 | Scott Bankhead | John Cerutti | Mark Eichhorn | Scott Bankhead | Tom Henke | 197 | 221 | -24 |
| 1987-05-23 | vs TOR | 42 | L 2-6 | 21-21 | 3 | 13,489 | Mike Moore | Jim Clancy | Jim Clancy | Mike Moore | | 199 | 227 | -28 |
| 1987-05-24 | vs TOR | 43 | W 5-2 | 22-21 | 2 | 12,751 | Mark Langston | Dave Stieb | Mark Langston | Dave Stieb | | 204 | 229 | -25 |
| 1987-05-25 | vs TOR | 44 | L 5-6 | 22-22 | 2 | 8,499 | Mike Morgan | Jimmy Key | Jimmy Key | Mike Morgan | Jeff Musselman | 209 | 235 | -26 |
| 1987-05-27 | @ NYA | 45 | W 6-5 | 23-22 | 3 | 26,741 | Scott Bankhead | Charles Hudson | Lee Guetterman | Ron Guidry | Mike Trujillo | 215 | 240 | -25 |
| 1987-05-28 | @ NYA | 46 | L 2-5 | 23-23 | 3 | 20,105 | Mike Moore | Rick Rhoden | Rick Rhoden | Mike Moore | Dave Righetti | 217 | 245 | -28 |
| 1987-05-29 | @ BAL | 47 | W 7-3 | 24-23 | 3 | 24,774 | Mark Langston | Jeff Ballard | Mark Langston | Jeff Ballard | | 224 | 248 | -24 |
| 1987-05-30 | @ BAL | 48 | W 12-0 | 25-23 | 2 | 28,874 | Mike Morgan | Eric Bell | Mike Morgan | Eric Bell | | 236 | 248 | -12 |
| 1987-05-31 | @ BAL | 49 | W 8-5 | 26-23 | 3 | 31,909 | Lee Guetterman | John Habyan | Lee Guetterman | John Habyan | | 244 | 253 | -9 |
| 1987-06-01 | @ TOR | 50 | W 2-0 | 27-23 | 3 | 28,294 | Scott Bankhead | Joe Johnson | Scott Bankhead | Joe Johnson | Bill Wilkinson | 246 | 253 | -7 |
| 1987-06-02 | @ TOR | 51 | L 3-4 | 27-24 | 3 | 31,076 | Mike Moore | Jim Clancy | Jeff Musselman | Mike Moore | Tom Henke | 249 | 257 | -8 |
| 1987-06-03 | @ TOR | 52 | L 2-7 | 27-25 | 3 | 30,502 | Mark Langston | Dave Stieb | Dave Stieb | Mark Langston | Mark Eichhorn | 251 | 264 | -13 |
| 1987-06-04 | vs KCA | 53 | L 1-6 | 27-26 | 4 | 12,153 | Mike Morgan | Bret Saberhagen | Bret Saberhagen | Mike Morgan | | 252 | 270 | -18 |
| 1987-06-05 | vs KCA | 54 | W 7-2 | 28-26 | 2 | 21,671 | Lee Guetterman | Danny Jackson | Lee Guetterman | Danny Jackson | Steve Shields | 259 | 272 | -13 |
| 1987-06-06 | vs KCA | 55 | L 2-5 | 28-27 | 4 | 25,083 | Scott Bankhead | Charlie Leibrandt | Charlie Leibrandt | Scott Bankhead | Dan Quisenberry | 261 | 277 | -16 |
| 1987-06-07 | vs KCA | 56 | L 1-9 | 28-28 | 4 | 12,859 | Mike Moore | Buddy Black | Buddy Black | Mike Moore | | 262 | 286 | -24 |
| 1987-06-08 | vs TEX | 57 | W 6-0 | 29-28 | 4 | 13,123 | Mark Langston | Mike Jeffcoat | Mark Langston | Mike Jeffcoat | | 268 | 286 | -18 |
| 1987-06-09 | vs TEX | 58 | L 0-3 | 29-29 | 4 | 6,729 | Mike Morgan | Jose Guzman | Jose Guzman | Mike Morgan | Dale Mohorcic | 268 | 289 | -21 |
| 1987-06-10 | vs TEX | 59 | L 5-9 | 29-30 | 4 | 7,449 | Lee Guetterman | Charlie Hough | Mitch Williams | Bill Wilkinson | Dale Mohorcic | 273 | 298 | -25 |
| 1987-06-12 | vs CLE | 60 | L 6-10 | 29-31 | 4 | 11,561 | Scott Bankhead | Greg Swindell | Mark Huismann | Mike Trujillo | | 279 | 308 | -29 |
| 1987-06-13 | vs CLE | 61 | L 1-6 | 29-32 | 4 | 14,013 | Mark Langston | Phil Niekro | Phil Niekro | Mark Langston | | 280 | 314 | -34 |
| 1987-06-14 | vs CLE | 62 | W 4-3 | 30-32 | 4 | 12,296 | Mike Morgan | Steve Carlton | Ed Nunez | Rich Yett | | 284 | 317 | -33 |
| 1987-06-15 | vs CHA | 63 | W 8-2 | 31-32 | 4 | 7,796 | Lee Guetterman | Floyd Bannister | Lee Guetterman | Floyd Bannister | Jerry Reed | 292 | 319 | -27 |
| 1987-06-16 | vs CHA | 64 | W 8-6 | 32-32 | 4 | 8,566 | Mike Moore | Neil Allen | Bill Wilkinson | Jim Winn | | 300 | 325 | -25 |
| 1987-06-17 | vs CHA | 65 | W 2-0 | 33-32 | 4 | 10,561 | Scott Bankhead | Bill Long | Scott Bankhead | Bill Long | Ed Nunez | 302 | 325 | -23 |
| 1987-06-19 | @ CLE | 66 | W 7-4 | 34-32 | 4 | 57,386 | Mark Langston | Phil Niekro | Mark Langston | Phil Niekro | | 309 | 329 | -20 |
| 1987-06-20 | @ CLE | 67 | L 2-9 | 34-33 | 4 | 12,307 | Mike Morgan | Steve Carlton | Steve Carlton | Mike Morgan | | 311 | 338 | -27 |
| 1987-06-21 | @ CLE | 68 | W 5-0 | 35-33 | 4 | 14,494 | Lee Guetterman | Ken Schrom | Lee Guetterman | Ken Schrom | | 316 | 338 | -22 |
| 1987-06-22 | @ CHA | 69 | W 3-0 | 36-33 | 4 | 11,873 | Mike Moore | Scott Nielsen | Mike Moore | Scott Nielsen | Bill Wilkinson | 319 | 338 | -19 |
| 1987-06-23 | @ CHA | 70 | L 3-13 | 36-34 | 4 | 13,408 | Scott Bankhead | Bill Long | Bill Long | Scott Bankhead | | 322 | 351 | -29 |
| 1987-06-24 | @ CHA | 71 | W 10-7 | 37-34 | 4 | 13,070 | Mark Langston | Richard Dotson | Mark Langston | Richard Dotson | Ed Nunez | 332 | 358 | -26 |
| 1987-06-26 | @ KCA | 72 | W 5-1 | 38-34 | 3 | 39,299 | Mike Morgan | Charlie Leibrandt | Mike Morgan | Charlie Leibrandt | Bill Wilkinson | 337 | 359 | -22 |
| 1987-06-27 | @ KCA | 73 | L 0-6 | 38-35 | 4 | 39,447 | Lee Guetterman | Bret Saberhagen | Bret Saberhagen | Lee Guetterman | | 337 | 365 | -28 |
| 1987-06-28 | @ KCA | 74 | L 3-8 | 38-36 | 4 | 32,634 | Mike Moore | Mark Gubicza | Mark Gubicza | Mike Moore | | 340 | 373 | -33 |
| 1987-06-29 | @ TEX | 75 | L 3-4 | 38-37 | 4 | 19,265 | Jerry Reed | Greg Harris | Mitch Williams | Stan Clarke | | 343 | 377 | -34 |
| 1987-06-30 | @ TEX | 76 | W 5-2 | 39-37 | 4 | 21,504 | Mark Langston | Mike Loynd | Mark Langston | Mike Loynd | | 348 | 379 | -31 |
| 1987-07-01 | @ TEX | 77 | L 3-7 | 39-38 | 4 | 22,569 | Mike Morgan | Charlie Hough | Charlie Hough | Mike Morgan | | 351 | 386 | -35 |
| 1987-07-02 | vs DET | 78 | W 5-2 | 40-38 | 4 | 10,646 | Lee Guetterman | Frank Tanana | Lee Guetterman | Frank Tanana | | 356 | 388 | -32 |
| 1987-07-03 | vs DET | 79 | L 2-5 | 40-39 | 4 | 13,568 | Mike Moore | Jeff Robinson | Jeff Robinson | Mike Moore | Eric King | 358 | 393 | -35 |
| 1987-07-04 | vs DET | 80 | L 3-7 | 40-40 | 4 | 16,884 | Mike Campbell | Jack Morris | Jack Morris | Mike Campbell | | 361 | 400 | -39 |
| 1987-07-05 | vs DET | 81 | L 5-7 | 40-41 | 5 | 13,232 | Mark Langston | Dan Petry | Dan Petry | Mark Langston | Mike Henneman | 366 | 407 | -41 |
| 1987-07-06 | vs MIL | 82 | W 3-2 | 41-41 | 5 | 15,922 | Mike Morgan | Bill Wegman | Mike Morgan | Bill Wegman | Ed Nunez | 369 | 409 | -40 |
| 1987-07-07 | vs MIL | 83 | W 9-5 | 42-41 | 5 | 9,041 | Lee Guetterman | Juan Nieves | Lee Guetterman | Juan Nieves | Jerry Reed | 378 | 414 | -36 |
| 1987-07-08 | vs MIL | 84 | W 5-2 | 43-41 | 5 | 8,482 | Mike Moore | Teddy Higuera | Bill Wilkinson | Dan Plesac | | 383 | 416 | -33 |
| 1987-07-09 | vs BOS | 85 | W 11-5 | 44-41 | 5 | 12,344 | Mike Campbell | Bruce Hurst | Roy Thomas | Wes Gardner | | 394 | 421 | -27 |
| 1987-07-10 | vs BOS | 86 | L 4-7 | 44-42 | 5 | 23,935 | Mark Langston | Oil Can Boyd | Calvin Schiraldi | Mark Langston | | 398 | 428 | -30 |
| 1987-07-11 | vs BOS | 87 | L 4-10 | 44-43 | 5 | 33,315 | Mike Morgan | Roger Clemens | Roger Clemens | Mike Morgan | | 402 | 438 | -36 |
| 1987-07-12 | vs BOS | 88 | W 6-1 | 45-43 | 5 | 13,391 | Lee Guetterman | Al Nipper | Lee Guetterman | Al Nipper | Jerry Reed | 408 | 439 | -31 |
| 1987-07-16 | @ DET | 89 | L 2-3 | 45-44 | 5 | 20,488 | Mike Moore | Walt Terrell | Walt Terrell | Mike Moore | | 410 | 442 | -32 |
| 1987-07-17 | @ DET | 90 | L 0-7 | 45-45 | 5 | 24,669 | Mark Langston | Frank Tanana | Frank Tanana | Mark Langston | | 410 | 449 | -39 |
| 1987-07-18 | @ DET | 91 | L 6-10 | 45-46 | 5 | 31,594 | Lee Guetterman | Dan Petry | Mike Henneman | Jerry Reed | Eric King | 416 | 459 | -43 |
| 1987-07-19 | @ DET | 92 | W 5-4 | 46-46 | 5 | 23,577 | Scott Bankhead | Jack Morris | Ed Nunez | Guillermo Hernandez | | 421 | 463 | -42 |
| 1987-07-20 | @ MIL | 93 | L 11-13 | 46-47 | 5 | 10,577 | Mike Morgan | Mark Knudson | Chuck Crim | Mike Morgan | Mark Clear | 432 | 476 | -44 |
| 1987-07-21 | @ MIL | 94 | L 4-6 | 46-48 | 5 | 13,373 | Mike Moore | Teddy Higuera | Teddy Higuera | Mike Moore | | 436 | 482 | -46 |
| 1987-07-22 | @ MIL | 95 | W 2-1 | 47-48 | 5 | 19,221 | Mark Langston | Bill Wegman | Mark Langston | Bill Wegman | | 438 | 483 | -45 |
| 1987-07-24 | @ BOS | 96 | L 4-5 | 47-49 | 5 | 29,999 | Lee Guetterman | Bruce Hurst | Bruce Hurst | Lee Guetterman | | 442 | 488 | -46 |
| 1987-07-25 | @ BOS | 97 | L 5-11 | 47-50 | 6 | 32,040 | Scott Bankhead | Oil Can Boyd | Tom Bolton | Stan Clarke | | 447 | 499 | -52 |
| 1987-07-26 | @ BOS | 98 | L 1-11 | 47-51 | 6 | 31,974 | Mike Moore | Roger Clemens | Roger Clemens | Mike Moore | | 448 | 510 | -62 |
| 1987-07-27 | vs MIN | 99 | L 3-4 | 47-52 | 6 | 13,858 | Mark Langston | Frank Viola | Frank Viola | Ed Nunez | Jeff Reardon | 451 | 514 | -63 |
| 1987-07-28 | vs MIN | 100 | W 6-1 | 48-52 | 6 | 13,495 | Mike Morgan | Joe Niekro | Mike Morgan | Joe Niekro | | 457 | 515 | -58 |
| 1987-07-29 | vs MIN | 101 | W 8-3 | 49-52 | 6 | 14,320 | Lee Guetterman | Mike Smithson | Lee Guetterman | Mike Smithson | | 465 | 518 | -53 |
| 1987-07-31 | @ CAL | 102 | L 2-8 | 49-53 | 6 | 32,471 | Scott Bankhead | Jerry Reuss | Jack Lazorko | Scott Bankhead | Greg Minton | 467 | 526 | -59 |
| 1987-08-01 | @ CAL | 103 | L 3-4 | 49-54 | 6 | 42,142 | Mike Moore | Willie Fraser | Willie Fraser | Mike Moore | DeWayne Buice | 470 | 530 | -60 |
| 1987-08-02 | @ CAL | 104 | W 5-4 | 50-54 | 6 | 28,318 | Mark Langston | Kirk McCaskill | Steve Shields | Greg Minton | | 475 | 534 | -59 |
| 1987-08-03 | @ OAK | 105 | W 4-3 | 51-54 | 5 | 16,644 | Mike Morgan | Joaquin Andujar | Mike Morgan | Joaquin Andujar | Ed Nunez | 479 | 537 | -58 |
| 1987-08-04 | @ OAK | 106 | L 3-9 | 51-55 | 5 | 10,335 | Lee Guetterman | Steve Ontiveros | Steve Ontiveros | Lee Guetterman | | 482 | 546 | -64 |
| 1987-08-05 | @ OAK | 107 | L 1-3 | 51-56 | 6 | 15,409 | Scott Bankhead | Jose Rijo | Jose Rijo | Scott Bankhead | Gene Nelson | 483 | 549 | -66 |
| 1987-08-06 | vs CAL | 108 | W 15-4 | 52-56 | 5 | 11,065 | Mike Moore | Willie Fraser | Mike Moore | Willie Fraser | | 498 | 553 | -55 |
| 1987-08-07 | vs CAL | 109 | W 14-0 | 53-56 | 5 | 12,464 | Mark Langston | Kirk McCaskill | Mark Langston | Kirk McCaskill | | 512 | 553 | -41 |
| 1987-08-08 | vs CAL | 110 | W 5-3 | 54-56 | 4 | 15,540 | Mike Morgan | Mike Witt | Mike Morgan | Mike Witt | Bill Wilkinson | 517 | 556 | -39 |
| 1987-08-09 | vs CAL | 111 | L 5-7 | 54-57 | 5 | 16,191 | Lee Guetterman | Don Sutton | DeWayne Buice | Dennis Powell | | 522 | 563 | -41 |
| 1987-08-10 | vs OAK | 112 | L 4-15 | 54-58 | 5 | 26,657 | Scott Bankhead | Dave Stewart | Dave Stewart | Scott Bankhead | | 526 | 578 | -52 |
| 1987-08-11 | vs OAK | 113 | W 8-2 | 55-58 | 5 | 10,859 | Mike Moore | Jose Rijo | Mike Moore | Jose Rijo | | 534 | 580 | -46 |
| 1987-08-12 | vs OAK | 114 | W 4-3 | 56-58 | 5 | 13,601 | Mark Langston | Gene Nelson | Mark Langston | Gene Nelson | Bill Wilkinson | 538 | 583 | -45 |
| 1987-08-14 | @ MIN | 115 | L 3-6 | 56-59 | 5 | 26,291 | Mike Morgan | Bert Blyleven | Bert Blyleven | Mike Morgan | | 541 | 589 | -48 |
| 1987-08-15 | @ MIN | 116 | L 4-14 | 56-60 | 5 | 31,154 | Lee Guetterman | Roy Smith | Roy Smith | Lee Guetterman | | 545 | 603 | -58 |
| 1987-08-16 | @ MIN | 117 | L 1-5 | 56-61 | 5 | 28,006 | Mike Moore | Frank Viola | Frank Viola | Mike Moore | | 546 | 608 | -62 |
| 1987-08-17 | @ MIN | 118 | L 2-4 | 56-62 | 5 | 29,623 | Mark Langston | Les Straker | Les Straker | Mark Langston | Jeff Reardon | 548 | 612 | -64 |
| 1987-08-18 | vs NYA | 119 | L 3-4 | 56-63 | 6 | 20,039 | Dennis Powell | Rick Rhoden | Tim Stoddard | Bill Wilkinson | Dave Righetti | 551 | 616 | -65 |
| 1987-08-19 | vs NYA | 120 | L 0-8 | 56-64 | 6 | 16,226 | Mike Morgan | Tommy John | Charles Hudson | Mike Morgan | | 551 | 624 | -73 |
| 1987-08-20 | vs NYA | 121 | W 4-3 | 57-64 | 6 | 18,095 | Mike Campbell | Dennis Rasmussen | Jerry Reed | Brad Arnsberg | | 555 | 627 | -72 |
| 1987-08-21 | vs BAL | 122 | W 3-2 | 58-64 | 5 | 10,114 | Mike Moore | Mike Flanagan | Mike Moore | Mike Flanagan | | 558 | 629 | -71 |
| 1987-08-22 | vs BAL | 123 | W 14-6 | 59-64 | 5 | 12,238 | Mark Langston | Dave J. Schmidt | Mark Langston | Dave J. Schmidt | | 572 | 635 | -63 |
| 1987-08-23 | vs BAL | 124 | L 5-6 | 59-65 | 5 | 13,595 | Dennis Powell | Ken Dixon | Ken Dixon | Dennis Powell | | 577 | 641 | -64 |
| 1987-08-24 | vs TOR | 125 | L 3-7 | 59-66 | 6 | 11,869 | Mike Morgan | John Cerutti | John Cerutti | Mike Morgan | | 580 | 648 | -68 |
| 1987-08-25 | vs TOR | 126 | L 3-6 | 59-67 | 6 | 12,367 | Mike Moore | Jim Clancy | Jim Clancy | Mike Moore | Mark Eichhorn | 583 | 654 | -71 |
| 1987-08-28 | @ NYA | 127 | W 10-4 | 60-67 | 6 | 22,095 | Dennis Powell | Steve Trout | Mike Trujillo | Charles Hudson | | 593 | 658 | -65 |
| 1987-08-29 | @ NYA | 128 | W 7-1 | 61-68 | 5 | 0 | Mark Langston | Rick Rhoden | Mark Langston | Rick Rhoden | | 600 | 659 | -59 |
| 1987-08-29 | @ NYA | 129 | L 2-4 | 61-68 | 5 | 37,276 | Mike Campbell | Tommy John | Tommy John | Mike Campbell | Dave Righetti | 602 | 663 | -61 |
| 1987-08-30 | @ NYA | 130 | L 1-4 | 61-69 | 5 | 37,854 | Mike Moore | Bill Gullickson | Bill Gullickson | Mike Moore | Dave Righetti | 603 | 667 | -64 |
| 1987-08-31 | @ BAL | 131 | L 3-4 | 61-70 | 6 | 15,411 | Mike Morgan | Mike Griffin | Mike Griffin | Mike Morgan | Tom Niedenfuer | 606 | 671 | -65 |
| 1987-09-01 | @ BAL | 132 | W 5-0 | 62-70 | 6 | 12,985 | Scott Bankhead | John Habyan | Scott Bankhead | John Habyan | | 611 | 671 | -60 |
| 1987-09-02 | @ BAL | 133 | W 8-6 | 63-70 | 5 | 22,418 | Mark Langston | Jeff Ballard | Mark Langston | Jeff Ballard | Jerry Reed | 619 | 677 | -58 |
| 1987-09-04 | @ TOR | 134 | L 5-6 | 63-71 | 5 | 33,042 | Mike Moore | Jim Clancy | Jose Nunez | Dennis Powell | | 624 | 683 | -59 |
| 1987-09-05 | @ TOR | 135 | L 0-3 | 63-72 | 5 | 38,436 | Mike Campbell | Mike Flanagan | Mike Flanagan | Mike Campbell | Tom Henke | 624 | 686 | -62 |
| 1987-09-06 | @ TOR | 136 | L 2-3 | 63-73 | 6 | 44,287 | Scott Bankhead | Jimmy Key | Jose Nunez | Ed Nunez | | 626 | 689 | -63 |
| 1987-09-07 | @ CLE | 137 | W 6-4 | 64-73 | 5 | 10,147 | Mark Langston | Tom Candiotti | Mark Langston | Tom Candiotti | Jerry Reed | 632 | 693 | -61 |
| 1987-09-08 | @ CLE | 138 | W 7-0 | 65-73 | 5 | 4,517 | Mike Morgan | Rich Yett | Mike Morgan | Rich Yett | | 639 | 693 | -54 |
| 1987-09-09 | @ CLE | 139 | W 9-4 | 66-73 | 5 | 4,849 | Mike Moore | Ken Schrom | Mike Moore | Jamie Easterly | | 648 | 697 | -49 |
| 1987-09-11 | vs CHA | 140 | L 1-5 | 66-74 | 5 | 9,282 | Mike Campbell | Jose DeLeon | Jose DeLeon | Mike Campbell | Bobby Thigpen | 649 | 702 | -53 |
| 1987-09-12 | vs CHA | 141 | W 12-2 | 67-74 | 5 | 10,193 | Scott Bankhead | Bill Long | Scott Bankhead | Bill Long | | 661 | 704 | -43 |
| 1987-09-13 | vs CHA | 142 | L 0-2 | 67-75 | 6 | 7,810 | Mark Langston | Floyd Bannister | Floyd Bannister | Mark Langston | | 661 | 706 | -45 |
| 1987-09-14 | vs CLE | 143 | L 8-11 | 67-76 | 6 | 7,839 | Mike Morgan | Rich Yett | Scott Bailes | Mike Morgan | Doug Jones | 669 | 717 | -48 |
| 1987-09-15 | vs CLE | 144 | L 2-4 | 67-77 | 6 | 8,017 | Mike Moore | Ken Schrom | Ken Schrom | Mike Moore | | 671 | 721 | -50 |
| 1987-09-16 | vs CLE | 145 | W 5-3 | 68-77 | 6 | 6,851 | Mike Campbell | John Farrell | Bill Wilkinson | Sammy Stewart | | 676 | 724 | -48 |
| 1987-09-17 | @ CHA | 146 | L 8-9 | 68-78 | 6 | 11,709 | Scott Bankhead | Bill Long | Bobby Thigpen | Bill Wilkinson | | 684 | 733 | -49 |
| 1987-09-18 | @ CHA | 147 | W 1-0 | 69-78 | 6 | 10,775 | Mark Langston | Floyd Bannister | Mark Langston | Floyd Bannister | | 685 | 733 | -48 |
| 1987-09-19 | @ CHA | 148 | L 8-10 | 69-79 | 6 | 12,405 | Mike Morgan | Adam Peterson | Bobby Thigpen | Ed Nunez | | 693 | 743 | -50 |
| 1987-09-20 | @ CHA | 149 | L 3-5 | 69-80 | 6 | 9,294 | Mike Moore | Jack McDowell | Jack McDowell | Mike Moore | Bobby Thigpen | 696 | 748 | -52 |
| 1987-09-21 | vs KCA | 150 | W 5-1 | 70-80 | 5 | 6,416 | Mike Campbell | Bret Saberhagen | Mike Campbell | Bret Saberhagen | | 701 | 749 | -48 |
| 1987-09-22 | vs KCA | 151 | L 3-4 | 70-81 | 6 | 7,706 | Scott Bankhead | Charlie Leibrandt | Jerry Gleaton | Jerry Reed | Gene Garber | 704 | 753 | -49 |
| 1987-09-23 | vs KCA | 152 | L 0-9 | 70-82 | 6 | 8,503 | Mark Langston | Mark Gubicza | Mark Gubicza | Mark Langston | | 704 | 762 | -58 |
| 1987-09-25 | vs TEX | 153 | W 12-3 | 71-82 | 6 | 7,246 | Mike Morgan | Bobby Witt | Mike Morgan | Bobby Witt | | 716 | 765 | -49 |
| 1987-09-26 | vs TEX | 154 | W 2-1 | 72-82 | 5 | 30,977 | Mike Moore | Paul Kilgus | Mike Moore | Paul Kilgus | Bill Wilkinson | 718 | 766 | -48 |
| 1987-09-27 | vs TEX | 155 | W 5-3 | 73-82 | 4 | 9,032 | Mike Campbell | Greg Harris | Mike Trujillo | Mitch Williams | Ed Nunez | 723 | 769 | -46 |
| 1987-09-28 | @ KCA | 156 | W 5-1 | 74-82 | 4 | 22,068 | Lee Guetterman | Mark Gubicza | Lee Guetterman | Mark Gubicza | Jerry Reed | 728 | 770 | -42 |
| 1987-09-29 | @ KCA | 157 | L 3-6 | 74-83 | 4 | 17,458 | Mark Langston | Buddy Black | Buddy Black | Mark Langston | | 731 | 776 | -45 |
| 1987-09-30 | @ KCA | 158 | L 3-7 | 74-84 | 6 | 16,162 | Mike Morgan | Danny Jackson | Danny Jackson | Mike Morgan | | 734 | 783 | -49 |
| 1987-10-01 | @ TEX | 159 | W 8-6 | 75-84 | 5 | 7,890 | Mike Moore | Mitch Williams | Mike Moore | Mitch Williams | Bill Wilkinson | 742 | 789 | -47 |
| 1987-10-02 | @ TEX | 160 | W 5-4 | 76-84 | 4 | 11,711 | Clay Parker | Greg Harris | Dennis Powell | Dale Mohorcic | Bill Wilkinson | 747 | 793 | -46 |
| 1987-10-03 | @ TEX | 161 | W 6-4 | 77-84 | 4 | 19,696 | Lee Guetterman | Jose Guzman | Lee Guetterman | Jose Guzman | Bill Wilkinson | 753 | 797 | -44 |
| 1987-10-04 | @ TEX | 162 | W 7-4 | 78-84 | 4 | 17,208 | Mark Langston | Charlie Hough | Mark Langston | Charlie Hough | Jerry Reed | 760 | 801 | -41 |