| 1987-04-07 | @ MIN | 1 | L 4-5 | 0-1 | 5 | 43,548 | Curt Young | Bert Blyleven | George Frazier | Bill Krueger | | 4 | 5 | -1 |
| 1987-04-08 | @ MIN | 2 | L 1-4 | 0-2 | 6 | 12,577 | Eric Plunk | Frank Viola | Frank Viola | Eric Plunk | Jeff Reardon | 5 | 9 | -4 |
| 1987-04-09 | @ MIN | 3 | L 4-5 | 0-3 | 7 | 11,586 | Chris Codiroli | Mark Portugal | Juan Berenguer | Jay Howell | | 9 | 14 | -5 |
| 1987-04-10 | vs CAL | 4 | L 4-6 | 0-4 | 7 | 46,120 | Dave Stewart | Kirk McCaskill | Kirk McCaskill | Dave Stewart | Donnie Moore | 13 | 20 | -7 |
| 1987-04-11 | vs CAL | 5 | L 3-6 | 0-5 | 7 | 30,136 | Jose Rijo | Urbano Lugo | Willie Fraser | Bill Krueger | Gary Lucas | 16 | 26 | -10 |
| 1987-04-12 | vs CAL | 6 | W 7-1 | 1-5 | 6 | 37,162 | Curt Young | Mike Witt | Curt Young | Mike Witt | | 23 | 27 | -4 |
| 1987-04-13 | vs MIN | 7 | W 6-3 | 2-5 | 5 | 14,447 | Eric Plunk | Frank Viola | Jay Howell | George Frazier | | 29 | 30 | -1 |
| 1987-04-14 | vs MIN | 8 | L 8-9 | 2-6 | 6 | 10,435 | Chris Codiroli | Mark Portugal | Keith Atherton | Chris Codiroli | Jeff Reardon | 37 | 39 | -2 |
| 1987-04-15 | vs MIN | 9 | L 2-5 | 2-7 | 6 | 17,182 | Dave Stewart | Mike Smithson | Mike Smithson | Dave Stewart | Jeff Reardon | 39 | 44 | -5 |
| 1987-04-16 | @ SEA | 10 | L 5-6 | 2-8 | 6 | 7,349 | Jose Rijo | Mike Trujillo | Mike Trujillo | Jose Rijo | Ed Nunez | 44 | 50 | -6 |
| 1987-04-17 | @ SEA | 11 | L 2-4 | 2-9 | 6 | 12,168 | Curt Young | Mark Langston | Mark Langston | Curt Young | | 46 | 54 | -8 |
| 1987-04-18 | @ SEA | 12 | W 7-5 | 3-9 | 6 | 19,383 | Eric Plunk | Mike Moore | Jay Howell | Mike Moore | | 53 | 59 | -6 |
| 1987-04-19 | @ SEA | 13 | L 1-8 | 3-10 | 6 | 8,036 | Chris Codiroli | Scott Bankhead | Scott Bankhead | Chris Codiroli | | 54 | 67 | -13 |
| 1987-04-20 | @ CAL | 14 | W 10-5 | 4-10 | 6 | 26,821 | Dave Stewart | Kirk McCaskill | Dave Stewart | Gary Lucas | Jay Howell | 64 | 72 | -8 |
| 1987-04-21 | @ CAL | 15 | L 5-8 | 4-11 | 6 | 27,388 | Jose Rijo | Urbano Lugo | Mike Cook | Dennis Eckersley | Willie Fraser | 69 | 80 | -11 |
| 1987-04-22 | @ CAL | 16 | W 7-6 | 5-11 | 6 | 30,157 | Curt Young | Mike Witt | Curt Young | Mike Witt | Jay Howell | 76 | 86 | -10 |
| 1987-04-24 | vs SEA | 17 | L 3-6 | 5-12 | 6 | 11,152 | Eric Plunk | Mike Moore | Mike Moore | Bill Krueger | | 79 | 92 | -13 |
| 1987-04-25 | vs SEA | 18 | W 7-3 | 6-12 | 6 | 15,720 | Dave Stewart | Scott Bankhead | Dave Stewart | Scott Bankhead | Dennis Eckersley | 86 | 95 | -9 |
| 1987-04-26 | vs SEA | 19 | L 5-8 | 6-13 | 7 | 16,603 | Jose Rijo | Mike Trujillo | Mike Trujillo | Jose Rijo | Ed Nunez | 91 | 103 | -12 |
| 1987-04-27 | vs BOS | 20 | W 5-2 | 7-13 | 7 | 25,109 | Curt Young | Bob Stanley | Curt Young | Bob Stanley | | 96 | 105 | -9 |
| 1987-04-28 | vs BOS | 21 | W 7-1 | 8-13 | 6 | 14,148 | Joaquin Andujar | Jeff Sellers | Dennis Eckersley | Jeff Sellers | | 103 | 106 | -3 |
| 1987-04-29 | vs MIL | 22 | L 7-8 | 8-14 | 6 | 11,879 | Eric Plunk | Teddy Higuera | Chris Bosio | Gene Nelson | Dan Plesac | 110 | 114 | -4 |
| 1987-04-30 | vs MIL | 23 | W 4-1 | 9-14 | 6 | 10,262 | Dave Stewart | Bill Wegman | Dave Stewart | Bill Wegman | Jay Howell | 114 | 115 | -1 |
| 1987-05-01 | vs DET | 24 | W 2-1 | 10-14 | 5 | 14,035 | Moose Haas | Walt Terrell | Dennis Eckersley | Bryan Kelly | | 116 | 116 | 0 |
| 1987-05-02 | vs DET | 25 | W 3-2 | 11-14 | 5 | 17,753 | Curt Young | Frank Tanana | Dave Leiper | Nate Snell | | 119 | 118 | 1 |
| 1987-05-03 | vs DET | 26 | W 2-0 | 12-14 | 5 | 21,810 | Eric Plunk | Eric King | Eric Plunk | Eric King | Jay Howell | 121 | 118 | 3 |
| 1987-05-05 | @ BOS | 27 | L 0-6 | 12-15 | 5 | 16,444 | Dave Stewart | Bruce Hurst | Bruce Hurst | Dave Stewart | | 121 | 124 | -3 |
| 1987-05-06 | @ BOS | 28 | L 2-6 | 12-16 | 5 | 19,154 | Dennis Eckersley | Roger Clemens | Calvin Schiraldi | Dennis Eckersley | | 123 | 130 | -7 |
| 1987-05-08 | @ DET | 29 | W 7-2 | 13-16 | 5 | 13,949 | Curt Young | Frank Tanana | Curt Young | Frank Tanana | | 130 | 132 | -2 |
| 1987-05-09 | @ DET | 30 | W 8-7 | 14-16 | 5 | 15,685 | Eric Plunk | Eric King | Gene Nelson | Mark Thurmond | Jay Howell | 138 | 139 | -1 |
| 1987-05-10 | @ DET | 31 | L 6-7 | 14-17 | 5 | 14,114 | Moose Haas | Jack Morris | Nate Snell | Steve Ontiveros | | 144 | 146 | -2 |
| 1987-05-12 | @ MIL | 32 | W 10-8 | 15-17 | 5 | 9,459 | Dave Stewart | Mike Birkbeck | Dave Stewart | Paul Mirabella | Jay Howell | 154 | 154 | 0 |
| 1987-05-13 | @ MIL | 33 | W 8-2 | 16-17 | 5 | 12,997 | Curt Young | Teddy Higuera | Curt Young | Teddy Higuera | | 162 | 156 | 6 |
| 1987-05-15 | vs TOR | 34 | L 2-3 | 16-18 | 5 | 13,139 | Eric Plunk | Joe Johnson | Joe Johnson | Eric Plunk | Tom Henke | 164 | 159 | 5 |
| 1987-05-16 | vs TOR | 35 | W 10-3 | 17-18 | 5 | 20,900 | Moose Haas | Jimmy Key | Moose Haas | Jimmy Key | | 174 | 162 | 12 |
| 1987-05-17 | vs TOR | 36 | W 3-0 | 18-18 | 5 | 30,511 | Dave Stewart | John Cerutti | Dave Stewart | John Cerutti | | 177 | 162 | 15 |
| 1987-05-18 | vs NYA | 37 | L 1-2 | 18-19 | 5 | 20,529 | Curt Young | Tommy John | Tommy John | Curt Young | Tim Stoddard | 178 | 164 | 14 |
| 1987-05-19 | vs NYA | 38 | W 4-2 | 19-19 | 5 | 16,103 | Steve Ontiveros | Dennis Rasmussen | Dennis Eckersley | Dennis Rasmussen | Jay Howell | 182 | 166 | 16 |
| 1987-05-20 | vs NYA | 39 | W 7-5 | 20-19 | 5 | 16,083 | Eric Plunk | Charles Hudson | Gene Nelson | Charles Hudson | | 189 | 171 | 18 |
| 1987-05-22 | vs BAL | 40 | L 6-10 | 20-20 | 4 | 15,137 | Moose Haas | Scott McGregor | Dave J. Schmidt | Moose Haas | Ken Dixon | 195 | 181 | 14 |
| 1987-05-23 | vs BAL | 41 | L 4-5 | 20-21 | 5 | 22,134 | Dave Stewart | Mike Boddicker | Mike Boddicker | Dave Stewart | Don Aase | 199 | 186 | 13 |
| 1987-05-24 | vs BAL | 42 | L 3-4 | 20-22 | 5 | 17,602 | Curt Young | Jeff Ballard | Jeff Ballard | Curt Young | Ken Dixon | 202 | 190 | 12 |
| 1987-05-25 | vs BAL | 43 | L 3-4 | 20-23 | 5 | 23,593 | Joaquin Andujar | Eric Bell | Eric Bell | Dennis Eckersley | Ken Dixon | 205 | 194 | 11 |
| 1987-05-27 | @ TOR | 44 | W 4-1 | 21-23 | 4 | 25,245 | Moose Haas | Joe Johnson | Moose Haas | Joe Johnson | Steve Ontiveros | 209 | 195 | 14 |
| 1987-05-28 | @ TOR | 45 | W 4-3 | 22-23 | 4 | 27,017 | Dave Stewart | Jim Clancy | Dave Stewart | Jim Clancy | Dave Leiper | 213 | 198 | 15 |
| 1987-05-29 | @ NYA | 46 | W 13-5 | 23-23 | 4 | 30,270 | Curt Young | Dennis Rasmussen | Curt Young | Dennis Rasmussen | | 226 | 203 | 23 |
| 1987-05-30 | @ NYA | 47 | W 4-3 | 24-23 | 4 | 28,790 | Joaquin Andujar | Joe Niekro | Joaquin Andujar | Joe Niekro | Jay Howell | 230 | 206 | 24 |
| 1987-05-31 | @ NYA | 48 | L 5-9 | 24-24 | 4 | 55,034 | Dennis Eckersley | Tommy John | Tommy John | Dennis Eckersley | | 235 | 215 | 20 |
| 1987-06-01 | @ BAL | 49 | W 9-6 | 25-24 | 4 | 18,857 | Moose Haas | Scott McGregor | Gene Nelson | Ken Dixon | Jay Howell | 244 | 221 | 23 |
| 1987-06-02 | @ BAL | 50 | L 2-9 | 25-25 | 4 | 25,174 | Dave Stewart | Mike Boddicker | Mike Boddicker | Dave Stewart | | 246 | 230 | 16 |
| 1987-06-03 | @ BAL | 51 | W 7-3 | 26-25 | 4 | 15,286 | Curt Young | Jeff Ballard | Curt Young | Jeff Ballard | | 253 | 233 | 20 |
| 1987-06-05 | vs CLE | 52 | L 3-4 | 26-26 | 4 | 13,937 | Joaquin Andujar | Tom Candiotti | Tom Candiotti | Joaquin Andujar | Scott Bailes | 256 | 237 | 19 |
| 1987-06-06 | vs CLE | 53 | W 6-4 | 27-26 | 3 | 16,728 | Moose Haas | Greg Swindell | Dennis Eckersley | Greg Swindell | | 262 | 241 | 21 |
| 1987-06-07 | vs CLE | 54 | L 2-12 | 27-27 | 3 | 30,118 | Dave Stewart | Steve Carlton | Steve Carlton | Dave Stewart | | 264 | 253 | 11 |
| 1987-06-08 | vs CHA | 55 | W 9-3 | 28-27 | 3 | 13,756 | Steve Ontiveros | Floyd Bannister | Steve Ontiveros | Floyd Bannister | Jay Howell | 273 | 256 | 17 |
| 1987-06-09 | vs CHA | 56 | W 8-3 | 29-27 | 3 | 12,505 | Curt Young | Jose DeLeon | Curt Young | Jose DeLeon | | 281 | 259 | 22 |
| 1987-06-10 | vs CHA | 57 | W 5-2 | 30-27 | 3 | 17,942 | Joaquin Andujar | Neil Allen | Dennis Eckersley | Neil Allen | Jay Howell | 286 | 261 | 25 |
| 1987-06-12 | @ TEX | 58 | W 6-1 | 31-27 | 3 | 20,393 | Dave Stewart | Greg Harris | Dave Stewart | Greg Harris | | 292 | 262 | 30 |
| 1987-06-13 | @ TEX | 59 | W 10-8 | 32-27 | 2 | 33,882 | Moose Haas | Ed Correa | Steve Ontiveros | Paul Kilgus | Jay Howell | 302 | 270 | 32 |
| 1987-06-14 | @ TEX | 60 | L 1-5 | 32-28 | 2 | 32,743 | Eric Plunk | Charlie Hough | Charlie Hough | Eric Plunk | | 303 | 275 | 28 |
| 1987-06-15 | @ KCA | 61 | W 7-6 | 33-28 | 2 | 36,157 | Curt Young | Charlie Leibrandt | Dave Leiper | Steve Farr | Jay Howell | 310 | 281 | 29 |
| 1987-06-16 | @ KCA | 62 | W 11-1 | 34-28 | 2 | 26,562 | Steve Ontiveros | Rick Anderson | Steve Ontiveros | Rick Anderson | | 321 | 282 | 39 |
| 1987-06-17 | @ KCA | 63 | L 5-10 | 34-29 | 2 | 26,780 | Dave Stewart | Bret Saberhagen | Bret Saberhagen | Dave Stewart | | 326 | 292 | 34 |
| 1987-06-19 | vs TEX | 64 | L 2-4 | 34-30 | 3 | 11,717 | Moose Haas | Charlie Hough | Charlie Hough | Moose Haas | Dale Mohorcic | 328 | 296 | 32 |
| 1987-06-20 | vs TEX | 65 | L 6-7 | 34-31 | 3 | 21,937 | Curt Young | Bobby Witt | Bobby Witt | Curt Young | Mitch Williams | 334 | 303 | 31 |
| 1987-06-21 | vs TEX | 66 | W 7-3 | 35-32 | 3 | 0 | Dave Stewart | Jose Guzman | Dave Stewart | Jose Guzman | Dennis Eckersley | 341 | 306 | 35 |
| 1987-06-21 | vs TEX | 67 | L 3-13 | 35-32 | 3 | 28,395 | Eric Plunk | Ed Correa | Ed Correa | Eric Plunk | Jeff Russell | 344 | 319 | 25 |
| 1987-06-22 | vs KCA | 68 | W 4-1 | 36-32 | 2 | 18,346 | Steve Ontiveros | Bret Saberhagen | Steve Ontiveros | Bret Saberhagen | Jay Howell | 348 | 320 | 28 |
| 1987-06-23 | vs KCA | 69 | L 0-4 | 36-33 | 3 | 13,121 | Jose Rijo | Mark Gubicza | Mark Gubicza | Jose Rijo | | 348 | 324 | 24 |
| 1987-06-24 | vs KCA | 70 | W 4-2 | 37-33 | 2 | 18,123 | Curt Young | Danny Jackson | Curt Young | Danny Jackson | Dennis Eckersley | 352 | 326 | 26 |
| 1987-06-26 | @ CLE | 71 | W 5-0 | 38-33 | 2 | 15,387 | Dave Stewart | Steve Carlton | Dave Stewart | Steve Carlton | Gene Nelson | 357 | 326 | 31 |
| 1987-06-27 | @ CLE | 72 | W 13-3 | 39-33 | 2 | 13,086 | Joaquin Andujar | Ken Schrom | Joaquin Andujar | Ken Schrom | | 370 | 329 | 41 |
| 1987-06-28 | @ CLE | 73 | W 10-0 | 40-33 | 2 | 17,762 | Steve Ontiveros | Tom Candiotti | Steve Ontiveros | Tom Candiotti | | 380 | 329 | 51 |
| 1987-06-29 | @ CHA | 74 | L 2-5 | 40-34 | 2 | 14,320 | Curt Young | Richard Dotson | Richard Dotson | Curt Young | | 382 | 334 | 48 |
| 1987-06-30 | @ CHA | 75 | L 3-12 | 40-35 | 2 | 10,559 | Jose Rijo | Scott Nielsen | Scott Nielsen | Jose Rijo | | 385 | 346 | 39 |
| 1987-07-01 | @ CHA | 76 | L 3-5 | 40-36 | 3 | 13,133 | Dave Stewart | Jose DeLeon | Jim Winn | Jay Howell | | 388 | 351 | 37 |
| 1987-07-02 | vs BOS | 77 | W 5-3 | 41-36 | 3 | 16,134 | Joaquin Andujar | Al Nipper | Joaquin Andujar | Al Nipper | | 393 | 354 | 39 |
| 1987-07-03 | vs BOS | 78 | L 0-2 | 41-37 | 3 | 43,050 | Steve Ontiveros | Jeff Sellers | Jeff Sellers | Steve Ontiveros | | 393 | 356 | 37 |
| 1987-07-04 | vs BOS | 79 | W 9-5 | 42-37 | 3 | 24,298 | Jose Rijo | Bruce Hurst | Jose Rijo | Bruce Hurst | Dennis Eckersley | 402 | 361 | 41 |
| 1987-07-05 | vs BOS | 80 | W 6-3 | 43-37 | 3 | 32,655 | Dave Stewart | Oil Can Boyd | Dave Stewart | Oil Can Boyd | Dennis Eckersley | 408 | 364 | 44 |
| 1987-07-06 | vs DET | 81 | W 5-3 | 44-37 | 3 | 14,656 | Dennis Lamp | Walt Terrell | Gene Nelson | Eric King | Jay Howell | 413 | 367 | 46 |
| 1987-07-07 | vs DET | 82 | L 4-6 | 44-38 | 3 | 17,174 | Joaquin Andujar | Frank Tanana | Frank Tanana | Joaquin Andujar | Guillermo Hernandez | 417 | 373 | 44 |
| 1987-07-08 | vs DET | 83 | L 5-9 | 44-39 | 3 | 20,031 | Steve Ontiveros | Jeff Robinson | Jeff Robinson | Steve Ontiveros | Mark Thurmond | 422 | 382 | 40 |
| 1987-07-09 | vs MIL | 84 | L 3-8 | 44-40 | 3 | 15,072 | Jose Rijo | Chris Bosio | Chris Bosio | Jose Rijo | | 425 | 390 | 35 |
| 1987-07-10 | vs MIL | 85 | W 7-3 | 45-40 | 3 | 14,733 | Dave Stewart | Mark Knudson | Dave Stewart | Mark Knudson | Dennis Eckersley | 432 | 393 | 39 |
| 1987-07-11 | vs MIL | 86 | W 6-5 | 46-40 | 3 | 28,399 | Joaquin Andujar | Bill Wegman | Dennis Eckersley | Dan Plesac | | 438 | 398 | 40 |
| 1987-07-12 | vs MIL | 87 | L 3-4 | 46-41 | 3 | 33,519 | Steve Ontiveros | Juan Nieves | Juan Nieves | Jay Howell | Dan Plesac | 441 | 402 | 39 |
| 1987-07-16 | @ BOS | 88 | W 6-3 | 47-41 | 2 | 34,861 | Dave Stewart | Roger Clemens | Dave Stewart | Roger Clemens | Dennis Eckersley | 447 | 405 | 42 |
| 1987-07-17 | @ BOS | 89 | W 11-6 | 48-41 | 2 | 34,543 | Joaquin Andujar | Oil Can Boyd | Greg Cadaret | Bob Stanley | | 458 | 411 | 47 |
| 1987-07-18 | @ BOS | 90 | L 3-5 | 48-42 | 2 | 34,720 | Jose Rijo | Bruce Hurst | Bruce Hurst | Dennis Eckersley | | 461 | 416 | 45 |
| 1987-07-19 | @ BOS | 91 | W 5-3 | 49-42 | 2 | 34,114 | Steve Ontiveros | Al Nipper | Jay Howell | Bob Stanley | Bill Caudill | 466 | 419 | 47 |
| 1987-07-20 | @ DET | 92 | L 4-5 | 49-43 | 2 | 22,692 | Curt Young | Jeff Robinson | Mike Henneman | Gene Nelson | | 470 | 424 | 46 |
| 1987-07-21 | @ DET | 93 | L 5-6 | 49-44 | 2 | 23,118 | Dave Stewart | Walt Terrell | Eric King | Jay Howell | | 475 | 430 | 45 |
| 1987-07-22 | @ DET | 94 | W 10-1 | 50-44 | 2 | 24,855 | Dennis Lamp | Frank Tanana | Dennis Lamp | Frank Tanana | | 485 | 431 | 54 |
| 1987-07-23 | @ MIL | 95 | L 5-12 | 50-45 | 2 | 14,475 | Joaquin Andujar | Chris Bosio | Chris Bosio | Joaquin Andujar | | 490 | 443 | 47 |
| 1987-07-24 | @ MIL | 96 | L 2-10 | 50-46 | 2 | 20,828 | Steve Ontiveros | Juan Nieves | Juan Nieves | Steve Ontiveros | | 492 | 453 | 39 |
| 1987-07-25 | @ MIL | 97 | W 13-4 | 51-46 | 2 | 34,344 | Curt Young | Mark Knudson | Curt Young | Mark Knudson | | 505 | 457 | 48 |
| 1987-07-26 | @ MIL | 98 | L 4-7 | 51-47 | 2 | 25,764 | Dennis Lamp | Teddy Higuera | Teddy Higuera | Dennis Lamp | Dan Plesac | 509 | 464 | 45 |
| 1987-07-27 | vs CAL | 99 | W 6-1 | 52-47 | 2 | 20,153 | Dave Stewart | Kirk McCaskill | Dave Stewart | Kirk McCaskill | | 515 | 465 | 50 |
| 1987-07-28 | vs CAL | 100 | L 2-9 | 52-48 | 2 | 16,326 | Joaquin Andujar | Mike Witt | Mike Witt | Joaquin Andujar | | 517 | 474 | 43 |
| 1987-07-29 | vs CAL | 101 | L 4-5 | 52-49 | 2 | 22,616 | Steve Ontiveros | Don Sutton | Don Sutton | Steve Ontiveros | DeWayne Buice | 521 | 479 | 42 |
| 1987-07-31 | vs MIN | 102 | L 3-5 | 52-50 | 3 | 32,097 | Dennis Lamp | Bert Blyleven | Bert Blyleven | Dennis Lamp | Jeff Reardon | 524 | 484 | 40 |
| 1987-08-01 | vs MIN | 103 | W 3-2 | 53-50 | 3 | 40,929 | Dave Stewart | Frank Viola | Dave Stewart | Frank Viola | | 527 | 486 | 41 |
| 1987-08-02 | vs MIN | 104 | W 6-5 | 54-50 | 2 | 33,215 | Curt Young | Les Straker | Gene Nelson | Jeff Reardon | | 533 | 491 | 42 |
| 1987-08-03 | vs SEA | 105 | L 3-4 | 54-51 | 2 | 16,644 | Joaquin Andujar | Mike Morgan | Mike Morgan | Joaquin Andujar | Ed Nunez | 536 | 495 | 41 |
| 1987-08-04 | vs SEA | 106 | W 9-3 | 55-51 | 2 | 10,335 | Steve Ontiveros | Lee Guetterman | Steve Ontiveros | Lee Guetterman | | 545 | 498 | 47 |
| 1987-08-05 | vs SEA | 107 | W 3-1 | 56-51 | 1 | 15,409 | Jose Rijo | Scott Bankhead | Jose Rijo | Scott Bankhead | Gene Nelson | 548 | 499 | 49 |
| 1987-08-06 | @ MIN | 108 | L 4-9 | 56-52 | 2 | 39,177 | Dave Stewart | Frank Viola | Frank Viola | Dave Stewart | | 552 | 508 | 44 |
| 1987-08-07 | @ MIN | 109 | L 4-9 | 56-53 | 2 | 36,146 | Dennis Lamp | Joe Niekro | Joe Niekro | Dennis Lamp | | 556 | 517 | 39 |
| 1987-08-08 | @ MIN | 110 | L 2-9 | 56-54 | 2 | 50,237 | Curt Young | Steve Carlton | Steve Carlton | Curt Young | | 558 | 526 | 32 |
| 1987-08-09 | @ MIN | 111 | L 5-7 | 56-55 | 3 | 33,948 | Steve Ontiveros | Bert Blyleven | Bert Blyleven | Steve Ontiveros | Jeff Reardon | 563 | 533 | 30 |
| 1987-08-10 | @ SEA | 112 | W 15-4 | 57-55 | 2 | 26,657 | Dave Stewart | Scott Bankhead | Dave Stewart | Scott Bankhead | | 578 | 537 | 41 |
| 1987-08-11 | @ SEA | 113 | L 2-8 | 57-56 | 2 | 10,859 | Jose Rijo | Mike Moore | Mike Moore | Jose Rijo | | 580 | 545 | 35 |
| 1987-08-12 | @ SEA | 114 | L 3-4 | 57-57 | 4 | 13,601 | Gene Nelson | Mark Langston | Mark Langston | Gene Nelson | Bill Wilkinson | 583 | 549 | 34 |
| 1987-08-14 | @ CAL | 115 | W 7-6 | 58-57 | 4 | 36,616 | Curt Young | Don Sutton | Rick Rodriguez | DeWayne Buice | Dennis Eckersley | 590 | 555 | 35 |
| 1987-08-15 | @ CAL | 116 | W 13-3 | 59-57 | 2 | 43,868 | Dave Stewart | John Candelaria | Dave Stewart | John Candelaria | | 603 | 558 | 45 |
| 1987-08-16 | @ CAL | 117 | W 9-6 | 60-57 | 2 | 40,457 | Steve Ontiveros | Willie Fraser | Greg Cadaret | Chuck Finley | Dennis Eckersley | 612 | 564 | 48 |
| 1987-08-17 | @ CAL | 118 | L 4-6 | 60-58 | 2 | 30,090 | Jose Rijo | Mike Witt | Mike Witt | Dave Leiper | DeWayne Buice | 616 | 570 | 46 |
| 1987-08-18 | vs TOR | 119 | L 1-2 | 60-59 | 2 | 34,823 | Gene Nelson | Dave Stieb | Dave Stieb | Dennis Eckersley | Tom Henke | 617 | 572 | 45 |
| 1987-08-19 | vs TOR | 120 | W 7-3 | 61-59 | 2 | 16,039 | Dave Stewart | John Cerutti | Dave Stewart | John Cerutti | | 624 | 575 | 49 |
| 1987-08-20 | vs TOR | 121 | L 6-7 | 61-60 | 2 | 12,607 | Curt Young | Jim Clancy | Gary Lavelle | Greg Cadaret | Tom Henke | 630 | 582 | 48 |
| 1987-08-21 | vs NYA | 122 | W 6-4 | 62-60 | 2 | 35,359 | Steve Ontiveros | Ron Guidry | Steve Ontiveros | Ron Guidry | Jay Howell | 636 | 586 | 50 |
| 1987-08-22 | vs NYA | 123 | W 6-0 | 63-60 | 2 | 40,116 | Gene Nelson | Steve Trout | Gene Nelson | Steve Trout | | 642 | 586 | 56 |
| 1987-08-23 | vs NYA | 124 | L 0-4 | 63-61 | 2 | 43,726 | Dave Stewart | Rick Rhoden | Rick Rhoden | Dave Stewart | Tim Stoddard | 642 | 590 | 52 |
| 1987-08-24 | vs BAL | 125 | W 7-3 | 64-61 | 2 | 25,135 | Jose Rijo | Mike Boddicker | Greg Cadaret | Mike Boddicker | | 649 | 593 | 56 |
| 1987-08-25 | vs BAL | 126 | W 9-7 | 65-61 | 2 | 12,410 | Curt Young | Eric Bell | Curt Young | Eric Bell | Eric Plunk | 658 | 600 | 58 |
| 1987-08-27 | @ TOR | 127 | L 4-9 | 65-62 | 2 | 38,026 | Steve Ontiveros | Jimmy Key | Jimmy Key | Greg Cadaret | | 662 | 609 | 53 |
| 1987-08-28 | @ TOR | 128 | W 3-2 | 66-62 | 1 | 32,256 | Dave Stewart | Dave Stieb | Dave Stewart | Dave Stieb | Dennis Eckersley | 665 | 611 | 54 |
| 1987-08-29 | @ TOR | 129 | W 6-5 | 67-62 | 1 | 42,388 | Gene Nelson | Phil Niekro | Eric Plunk | Mark Eichhorn | Dennis Eckersley | 671 | 616 | 55 |
| 1987-08-30 | @ TOR | 130 | L 3-13 | 67-63 | 2 | 38,211 | Jose Rijo | Jim Clancy | Jim Clancy | Jose Rijo | | 674 | 629 | 45 |
| 1987-08-31 | @ NYA | 131 | L 1-4 | 67-64 | 2 | 25,597 | Curt Young | Ron Guidry | Ron Guidry | Curt Young | Tim Stoddard | 675 | 633 | 42 |
| 1987-09-01 | @ NYA | 132 | W 8-3 | 68-64 | 2 | 31,170 | Steve Ontiveros | Charles Hudson | Steve Ontiveros | Charles Hudson | | 683 | 636 | 47 |
| 1987-09-02 | @ NYA | 133 | L 2-3 | 68-65 | 2 | 33,619 | Dave Stewart | Tommy John | Dave Righetti | Rick Honeycutt | | 685 | 639 | 46 |
| 1987-09-04 | @ BAL | 134 | L 2-5 | 68-66 | 2 | 19,275 | Gene Nelson | Mike Boddicker | Mike Boddicker | Gene Nelson | | 687 | 644 | 43 |
| 1987-09-05 | @ BAL | 135 | W 7-2 | 69-66 | 2 | 21,291 | Curt Young | Eric Bell | Curt Young | Eric Bell | | 694 | 646 | 48 |
| 1987-09-06 | @ BAL | 136 | L 6-7 | 69-67 | 2 | 18,160 | Steve Ontiveros | John Habyan | Tom Niedenfuer | Dennis Eckersley | | 700 | 653 | 47 |
| 1987-09-07 | vs TEX | 137 | W 2-1 | 70-67 | 2 | 27,691 | Dave Stewart | Paul Kilgus | Dave Stewart | Mitch Williams | | 702 | 654 | 48 |
| 1987-09-08 | vs TEX | 138 | L 1-12 | 70-68 | 2 | 12,287 | Gene Nelson | Charlie Hough | Charlie Hough | Gene Nelson | | 703 | 666 | 37 |
| 1987-09-09 | vs TEX | 139 | W 11-7 | 71-68 | 2 | 10,143 | Storm Davis | Bobby Witt | Greg Cadaret | Bobby Witt | | 714 | 673 | 41 |
| 1987-09-10 | vs KCA | 140 | W 3-2 | 72-68 | 2 | 12,361 | Curt Young | Danny Jackson | Eric Plunk | John Davis | | 717 | 675 | 42 |
| 1987-09-11 | vs KCA | 141 | L 0-9 | 72-69 | 2 | 22,296 | Steve Ontiveros | Bret Saberhagen | Bret Saberhagen | Steve Ontiveros | | 717 | 684 | 33 |
| 1987-09-12 | vs KCA | 142 | L 7-10 | 72-70 | 2 | 38,095 | Dave Stewart | Charlie Leibrandt | Charlie Leibrandt | Dave Stewart | Gene Garber | 724 | 694 | 30 |
| 1987-09-13 | vs KCA | 143 | L 5-6 | 72-71 | 3 | 27,683 | Rick Honeycutt | Mark Gubicza | Mark Gubicza | Rick Honeycutt | Gene Garber | 729 | 700 | 29 |
| 1987-09-14 | @ TEX | 144 | L 1-2 | 72-72 | 3 | 11,888 | Storm Davis | Bobby Witt | Dale Mohorcic | Steve Ontiveros | | 730 | 702 | 28 |
| 1987-09-15 | @ TEX | 145 | W 6-5 | 73-72 | 3 | 9,533 | Curt Young | Greg Harris | Eric Plunk | Dale Mohorcic | Dennis Eckersley | 736 | 707 | 29 |
| 1987-09-16 | @ TEX | 146 | L 1-4 | 73-73 | 3 | 10,953 | Dave Stewart | Charlie Hough | Charlie Hough | Dave Stewart | | 737 | 711 | 26 |
| 1987-09-18 | @ KCA | 147 | W 4-0 | 74-73 | 2 | 31,301 | Steve Ontiveros | Mark Gubicza | Steve Ontiveros | Mark Gubicza | Dennis Eckersley | 741 | 711 | 30 |
| 1987-09-19 | @ KCA | 148 | W 9-5 | 75-73 | 2 | 38,685 | Storm Davis | Melido Perez | Storm Davis | Melido Perez | | 750 | 716 | 34 |
| 1987-09-20 | @ KCA | 149 | W 7-6 | 76-73 | 2 | 26,461 | Curt Young | Danny Jackson | Curt Young | Danny Jackson | Dennis Eckersley | 757 | 722 | 35 |
| 1987-09-21 | @ CLE | 150 | L 3-6 | 76-74 | 2 | 4,532 | Dave Stewart | Ken Schrom | Doug Jones | Dave Stewart | | 760 | 728 | 32 |
| 1987-09-22 | @ CLE | 151 | W 10-2 | 77-74 | 2 | 4,682 | Rick Honeycutt | John Farrell | Rick Honeycutt | John Farrell | Gene Nelson | 770 | 730 | 40 |
| 1987-09-23 | @ CLE | 152 | L 6-8 | 77-75 | 2 | 4,879 | Steve Ontiveros | Darrel Akerfelds | Ed Vande Berg | Eric Plunk | Sammy Stewart | 776 | 738 | 38 |
| 1987-09-24 | vs CHA | 153 | L 2-4 | 77-76 | 2 | 10,248 | Storm Davis | Floyd Bannister | Floyd Bannister | Storm Davis | | 778 | 742 | 36 |
| 1987-09-25 | vs CHA | 154 | L 1-2 | 77-77 | 3 | 25,152 | Dave Stewart | Jack McDowell | Bobby Thigpen | Dennis Eckersley | | 779 | 744 | 35 |
| 1987-09-26 | vs CHA | 155 | L 2-3 | 77-78 | 3 | 28,728 | Curt Young | Jose DeLeon | Bob James | Eric Plunk | | 781 | 747 | 34 |
| 1987-09-27 | vs CHA | 156 | L 0-5 | 77-79 | 3 | 23,704 | Rick Honeycutt | Dave LaPoint | Dave LaPoint | Rick Honeycutt | | 781 | 752 | 29 |
| 1987-09-29 | vs CLE | 157 | W 5-4 | 78-79 | 3 | 7,291 | Steve Ontiveros | John Farrell | Steve Ontiveros | Doug Jones | Dennis Eckersley | 786 | 756 | 30 |
| 1987-09-30 | vs CLE | 158 | W 4-3 | 79-79 | 3 | 9,428 | Dave Stewart | Darrel Akerfelds | Dave Stewart | Darrel Akerfelds | Eric Plunk | 790 | 759 | 31 |
| 1987-10-01 | vs CLE | 159 | W 9-5 | 80-79 | 3 | 9,846 | Storm Davis | Tom Candiotti | Greg Cadaret | Tom Candiotti | Dennis Eckersley | 799 | 764 | 35 |
| 1987-10-02 | @ CHA | 160 | W 4-3 | 81-79 | 3 | 8,226 | Curt Young | Jose DeLeon | Greg Cadaret | Bob James | | 803 | 767 | 36 |
| 1987-10-03 | @ CHA | 161 | L 1-17 | 81-80 | 3 | 12,747 | Rick Honeycutt | Dave LaPoint | Dave LaPoint | Rick Honeycutt | | 804 | 784 | 20 |
| 1987-10-04 | @ CHA | 162 | L 2-5 | 81-81 | 3 | 15,083 | Dave Stewart | Floyd Bannister | Floyd Bannister | Dave Stewart | Bobby Thigpen | 806 | 789 | 17 |