| 1987-04-06 | @ DET | 1 | W 2-1 | 1-0 | 3 | 51,315 | Dennis Rasmussen | Jack Morris | Dave Righetti | Jack Morris | | 2 | 1 | 1 |
| 1987-04-08 | @ DET | 2 | W 6-5 | 2-0 | 2 | 12,271 | Tommy John | Dan Petry | Charles Hudson | Guillermo Hernandez | Dave Righetti | 8 | 6 | 2 |
| 1987-04-09 | @ DET | 3 | L 3-9 | 2-1 | 3 | 12,228 | Bob Tewksbury | Walt Terrell | Walt Terrell | Bob Tewksbury | | 11 | 15 | -4 |
| 1987-04-10 | @ KCA | 4 | L 1-13 | 2-2 | 4 | 28,632 | Rick Rhoden | Bret Saberhagen | Bret Saberhagen | Rick Rhoden | | 12 | 28 | -16 |
| 1987-04-11 | @ KCA | 5 | W 15-2 | 3-2 | 4 | 31,303 | Dennis Rasmussen | Danny Jackson | Dennis Rasmussen | Danny Jackson | | 27 | 30 | -3 |
| 1987-04-12 | @ KCA | 6 | L 2-8 | 3-3 | 4 | 28,154 | Joe Niekro | Charlie Leibrandt | Charlie Leibrandt | Joe Niekro | | 29 | 38 | -9 |
| 1987-04-13 | vs CLE | 7 | W 11-3 | 4-3 | 4 | 55,612 | Charles Hudson | Greg Swindell | Charles Hudson | Greg Swindell | | 40 | 41 | -1 |
| 1987-04-14 | vs CLE | 8 | W 10-6 | 5-3 | 3 | 20,129 | Bob Tewksbury | Phil Niekro | Cecilio Guante | Steve Carlton | | 50 | 47 | 3 |
| 1987-04-15 | vs CLE | 9 | W 4-3 | 6-3 | 2 | 20,051 | Rick Rhoden | Scott Bailes | Rick Rhoden | Tom Waddell | Dave Righetti | 54 | 50 | 4 |
| 1987-04-18 | vs KCA | 10 | W 7-6 | 7-3 | 2 | 22,053 | Dennis Rasmussen | Danny Jackson | Dave Righetti | Steve Farr | | 61 | 56 | 5 |
| 1987-04-19 | vs KCA | 11 | W 5-0 | 9-3 | 2 | 0 | Charles Hudson | Charlie Leibrandt | Charles Hudson | Charlie Leibrandt | | 66 | 56 | 10 |
| 1987-04-19 | vs KCA | 12 | W 1-0 | 9-3 | 2 | 40,939 | Tommy John | Mark Gubicza | Pat Clements | Mark Gubicza | Dave Righetti | 67 | 56 | 11 |
| 1987-04-20 | vs DET | 13 | W 8-2 | 10-3 | 2 | 20,111 | Rick Rhoden | Jack Morris | Rick Rhoden | Jack Morris | Dave Righetti | 75 | 58 | 17 |
| 1987-04-21 | vs DET | 14 | W 3-1 | 11-3 | 2 | 25,148 | Joe Niekro | Walt Terrell | Joe Niekro | Walt Terrell | Cecilio Guante | 78 | 59 | 19 |
| 1987-04-22 | vs DET | 15 | W 4-1 | 12-3 | 2 | 21,091 | Bob Shirley | Frank Tanana | Bob Shirley | Frank Tanana | Dave Righetti | 82 | 60 | 22 |
| 1987-04-23 | @ CLE | 16 | W 5-4 | 13-3 | 2 | 8,157 | Dennis Rasmussen | Greg Swindell | Dennis Rasmussen | Greg Swindell | Dave Righetti | 87 | 64 | 23 |
| 1987-04-24 | @ CLE | 17 | L 5-6 | 13-4 | 2 | 14,336 | Charles Hudson | Phil Niekro | Steve Carlton | Dave Righetti | | 92 | 70 | 22 |
| 1987-04-25 | @ CLE | 18 | L 1-2 | 13-5 | 2 | 17,207 | Rick Rhoden | Scott Bailes | Scott Bailes | Rick Rhoden | Frank Wills | 93 | 72 | 21 |
| 1987-04-26 | @ CLE | 19 | W 14-2 | 14-5 | 2 | 25,108 | Tommy John | Tom Candiotti | Tommy John | Tom Candiotti | | 107 | 74 | 33 |
| 1987-04-28 | @ TEX | 20 | L 1-3 | 14-6 | 2 | 21,201 | Dennis Rasmussen | Ed Correa | Ed Correa | Dennis Rasmussen | Dale Mohorcic | 108 | 77 | 31 |
| 1987-04-29 | @ TEX | 21 | L 7-8 | 14-7 | 2 | 19,562 | Charles Hudson | Mike Mason | Mitch Williams | Cecilio Guante | | 115 | 85 | 30 |
| 1987-05-01 | @ MIN | 22 | L 4-7 | 14-8 | 2 | 23,531 | Rick Rhoden | Bert Blyleven | Bert Blyleven | Rick Rhoden | Jeff Reardon | 119 | 92 | 27 |
| 1987-05-02 | @ MIN | 23 | W 6-4 | 15-8 | 2 | 33,173 | Tommy John | Frank Viola | Tommy John | Frank Viola | Dave Righetti | 125 | 96 | 29 |
| 1987-05-03 | @ MIN | 24 | L 3-4 | 15-9 | 3 | 23,798 | Dennis Rasmussen | Mark Portugal | George Frazier | Tim Stoddard | Jeff Reardon | 128 | 100 | 28 |
| 1987-05-04 | @ CHA | 25 | W 6-1 | 16-9 | 3 | 13,467 | Charles Hudson | Richard Dotson | Charles Hudson | Richard Dotson | | 134 | 101 | 33 |
| 1987-05-05 | @ CHA | 26 | L 0-2 | 16-10 | 3 | 16,341 | Joe Niekro | Bill Long | Bill Long | Joe Niekro | | 134 | 103 | 31 |
| 1987-05-06 | @ CHA | 27 | W 4-1 | 17-10 | 2 | 13,737 | Rick Rhoden | Floyd Bannister | Rick Rhoden | Floyd Bannister | | 138 | 104 | 34 |
| 1987-05-08 | vs MIN | 28 | W 11-7 | 18-10 | 2 | 25,921 | Tommy John | Mark Portugal | Cecilio Guante | Jeff Reardon | | 149 | 111 | 38 |
| 1987-05-09 | vs MIN | 29 | L 0-2 | 18-11 | 3 | 27,220 | Dennis Rasmussen | Les Straker | Les Straker | Dennis Rasmussen | Jeff Reardon | 149 | 113 | 36 |
| 1987-05-10 | vs MIN | 30 | W 6-1 | 19-11 | 2 | 41,691 | Charles Hudson | Mike Smithson | Charles Hudson | Mike Smithson | | 155 | 114 | 41 |
| 1987-05-11 | vs CHA | 31 | W 3-2 | 20-11 | 2 | 20,236 | Rick Rhoden | Floyd Bannister | Rick Rhoden | Floyd Bannister | Dave Righetti | 158 | 116 | 42 |
| 1987-05-12 | vs CHA | 32 | W 5-4 | 21-11 | 2 | 20,634 | Joe Niekro | Bill Long | Cecilio Guante | Bobby Thigpen | | 163 | 120 | 43 |
| 1987-05-13 | vs TEX | 33 | L 6-8 | 21-12 | 2 | 22,040 | Tommy John | Jose Guzman | Jose Guzman | Tommy John | Dale Mohorcic | 169 | 128 | 41 |
| 1987-05-14 | vs TEX | 34 | W 9-1 | 22-12 | 1 | 22,635 | Dennis Rasmussen | Ed Correa | Dennis Rasmussen | Ed Correa | | 178 | 129 | 49 |
| 1987-05-15 | @ SEA | 35 | W 7-3 | 23-12 | 1 | 27,923 | Charles Hudson | Mike Morgan | Charles Hudson | Mike Morgan | Dave Righetti | 185 | 132 | 53 |
| 1987-05-16 | @ SEA | 36 | L 8-10 | 23-13 | 1 | 42,570 | Rick Rhoden | Scott Bankhead | Steve Shields | Cecilio Guante | | 193 | 142 | 51 |
| 1987-05-17 | @ SEA | 37 | W 8-3 | 24-13 | 1 | 32,832 | Joe Niekro | Mike Moore | Joe Niekro | Mike Moore | Dave Righetti | 201 | 145 | 56 |
| 1987-05-18 | @ OAK | 38 | W 2-1 | 25-13 | 1 | 20,529 | Tommy John | Curt Young | Tommy John | Curt Young | Tim Stoddard | 203 | 146 | 57 |
| 1987-05-19 | @ OAK | 39 | L 2-4 | 25-14 | 1 | 16,103 | Dennis Rasmussen | Steve Ontiveros | Dennis Eckersley | Dennis Rasmussen | Jay Howell | 205 | 150 | 55 |
| 1987-05-20 | @ OAK | 40 | L 5-7 | 25-15 | 1 | 16,083 | Charles Hudson | Eric Plunk | Gene Nelson | Charles Hudson | | 210 | 157 | 53 |
| 1987-05-22 | @ CAL | 41 | W 7-2 | 26-15 | 1 | 50,110 | Rick Rhoden | Mike Witt | Rick Rhoden | Mike Witt | | 217 | 159 | 58 |
| 1987-05-23 | @ CAL | 42 | W 3-0 | 27-15 | 1 | 43,781 | Joe Niekro | Willie Fraser | Joe Niekro | Willie Fraser | Dave Righetti | 220 | 159 | 61 |
| 1987-05-24 | @ CAL | 43 | W 10-8 | 28-15 | 1 | 40,949 | Dennis Rasmussen | Don Sutton | Dave Righetti | Donnie Moore | | 230 | 167 | 63 |
| 1987-05-25 | @ CAL | 44 | W 6-3 | 29-15 | 1 | 34,762 | Tommy John | Jack Lazorko | Tommy John | Jack Lazorko | Tim Stoddard | 236 | 170 | 66 |
| 1987-05-27 | vs SEA | 45 | L 5-6 | 29-16 | 1 | 26,741 | Charles Hudson | Scott Bankhead | Lee Guetterman | Ron Guidry | Mike Trujillo | 241 | 176 | 65 |
| 1987-05-28 | vs SEA | 46 | W 5-2 | 30-16 | 1 | 20,105 | Rick Rhoden | Mike Moore | Rick Rhoden | Mike Moore | Dave Righetti | 246 | 178 | 68 |
| 1987-05-29 | vs OAK | 47 | L 5-13 | 30-17 | 1 | 30,270 | Dennis Rasmussen | Curt Young | Curt Young | Dennis Rasmussen | | 251 | 191 | 60 |
| 1987-05-30 | vs OAK | 48 | L 3-4 | 30-18 | 1 | 28,790 | Joe Niekro | Joaquin Andujar | Joaquin Andujar | Joe Niekro | Jay Howell | 254 | 195 | 59 |
| 1987-05-31 | vs OAK | 49 | W 9-5 | 31-18 | 1 | 55,034 | Tommy John | Dennis Eckersley | Tommy John | Dennis Eckersley | | 263 | 200 | 63 |
| 1987-06-01 | vs CAL | 50 | L 2-9 | 31-19 | 1 | 21,154 | Charles Hudson | Mike Witt | Mike Witt | Charles Hudson | | 265 | 209 | 56 |
| 1987-06-02 | vs CAL | 51 | W 3-2 | 32-19 | 1 | 23,552 | Rick Rhoden | Willie Fraser | Dave Righetti | Willie Fraser | | 268 | 211 | 57 |
| 1987-06-03 | vs CAL | 52 | W 9-3 | 33-19 | 1 | 18,244 | Dennis Rasmussen | Don Sutton | Rich Bordi | Don Sutton | | 277 | 214 | 63 |
| 1987-06-04 | @ MIL | 53 | L 3-9 | 33-20 | 1 | 23,093 | Joe Niekro | Teddy Higuera | Teddy Higuera | Joe Niekro | | 280 | 223 | 57 |
| 1987-06-05 | @ MIL | 54 | W 13-1 | 34-20 | 1 | 36,951 | Tommy John | Juan Nieves | Tommy John | Juan Nieves | | 293 | 224 | 69 |
| 1987-06-06 | @ MIL | 55 | L 6-7 | 34-21 | 1 | 52,366 | Charles Hudson | Bill Wegman | Dan Plesac | Dave Righetti | | 299 | 231 | 68 |
| 1987-06-07 | @ MIL | 56 | W 5-3 | 35-21 | 1 | 52,770 | Dennis Rasmussen | Chuck Crim | Rich Bordi | Chuck Crim | Pat Clements | 304 | 234 | 70 |
| 1987-06-08 | vs TOR | 57 | L 0-11 | 35-22 | 2 | 25,526 | Rick Rhoden | Dave Stieb | Dave Stieb | Rick Rhoden | | 304 | 245 | 59 |
| 1987-06-09 | vs TOR | 58 | L 2-7 | 35-23 | 2 | 29,765 | Ron Guidry | John Cerutti | John Cerutti | Ron Guidry | | 306 | 252 | 54 |
| 1987-06-10 | vs TOR | 59 | L 1-4 | 35-24 | 2 | 26,806 | Tommy John | Jimmy Key | Jimmy Key | Tommy John | Tom Henke | 307 | 256 | 51 |
| 1987-06-12 | vs MIL | 60 | W 8-3 | 36-24 | 2 | 31,789 | Dennis Rasmussen | Chuck Crim | Dennis Rasmussen | Chuck Crim | | 315 | 259 | 56 |
| 1987-06-13 | vs MIL | 61 | W 4-1 | 37-24 | 2 | 30,231 | Rick Rhoden | Juan Nieves | Rick Rhoden | Juan Nieves | Dave Righetti | 319 | 260 | 59 |
| 1987-06-14 | vs MIL | 62 | L 4-6 | 37-25 | 2 | 50,351 | Ron Guidry | Teddy Higuera | Dan Plesac | Dave Righetti | | 323 | 266 | 57 |
| 1987-06-15 | vs BAL | 63 | W 9-2 | 38-25 | 2 | 20,313 | Tommy John | Eric Bell | Tommy John | Eric Bell | Pat Clements | 332 | 268 | 64 |
| 1987-06-16 | vs BAL | 64 | W 6-5 | 39-25 | 2 | 28,292 | Charles Hudson | Ken Dixon | Rich Bordi | Mark Williamson | Dave Righetti | 338 | 273 | 65 |
| 1987-06-17 | vs BAL | 65 | W 4-3 | 40-25 | 2 | 30,267 | Dennis Rasmussen | Mike Boddicker | Dennis Rasmussen | Mike Boddicker | Pat Clements | 342 | 276 | 66 |
| 1987-06-18 | vs BAL | 66 | W 6-3 | 41-25 | 2 | 23,225 | Rick Rhoden | Scott McGregor | Rick Rhoden | Scott McGregor | Tim Stoddard | 348 | 279 | 69 |
| 1987-06-19 | @ BOS | 67 | W 10-5 | 42-25 | 2 | 33,835 | Ron Guidry | Bruce Hurst | Charles Hudson | Joe Sambito | | 358 | 284 | 74 |
| 1987-06-20 | @ BOS | 68 | L 4-9 | 42-26 | 2 | 33,134 | Tommy John | Al Nipper | Al Nipper | Tommy John | | 362 | 293 | 69 |
| 1987-06-21 | @ BOS | 69 | L 2-4 | 42-27 | 2 | 33,012 | Bob Tewksbury | Roger Clemens | Roger Clemens | Bob Tewksbury | | 364 | 297 | 67 |
| 1987-06-22 | @ BAL | 70 | W 7-3 | 43-27 | 2 | 26,331 | Dennis Rasmussen | Mike Boddicker | Dennis Rasmussen | Luis DeLeon | | 371 | 300 | 71 |
| 1987-06-23 | @ BAL | 71 | W 2-1 | 44-27 | 2 | 27,187 | Rick Rhoden | Mark Williamson | Rick Rhoden | Doug Corbett | Dave Righetti | 373 | 301 | 72 |
| 1987-06-24 | @ BAL | 72 | L 0-4 | 44-28 | 2 | 31,070 | Ron Guidry | Dave J. Schmidt | Dave J. Schmidt | Ron Guidry | | 373 | 305 | 68 |
| 1987-06-26 | vs BOS | 73 | W 12-11 | 45-28 | 2 | 45,123 | Tommy John | Roger Clemens | Tim Stoddard | Calvin Schiraldi | | 385 | 316 | 69 |
| 1987-06-27 | vs BOS | 74 | W 9-1 | 46-28 | 2 | 47,829 | Bob Tewksbury | Oil Can Boyd | Bob Tewksbury | Oil Can Boyd | | 394 | 317 | 77 |
| 1987-06-28 | vs BOS | 75 | L 2-6 | 46-29 | 2 | 54,172 | Rick Rhoden | Al Nipper | Al Nipper | Rick Rhoden | | 396 | 323 | 73 |
| 1987-06-29 | @ TOR | 76 | W 15-14 | 47-29 | 1 | 42,179 | Dennis Rasmussen | John Cerutti | Dave Righetti | Tom Henke | | 411 | 337 | 74 |
| 1987-06-30 | @ TOR | 77 | W 4-0 | 48-29 | 1 | 45,297 | Ron Guidry | David Wells | Ron Guidry | David Wells | | 415 | 337 | 78 |
| 1987-07-01 | @ TOR | 78 | W 6-1 | 49-29 | 1 | 47,828 | Tommy John | Jimmy Key | Pat Clements | Jeff Musselman | | 421 | 338 | 83 |
| 1987-07-03 | vs TEX | 79 | L 0-9 | 50-30 | 1 | 0 | Bob Tewksbury | Bobby Witt | Bobby Witt | Bob Tewksbury | | 421 | 347 | 74 |
| 1987-07-03 | vs TEX | 80 | W 3-1 | 50-30 | 1 | 43,856 | Rick Rhoden | Jose Guzman | Rick Rhoden | Jose Guzman | Dave Righetti | 424 | 348 | 76 |
| 1987-07-04 | vs TEX | 81 | W 4-3 | 51-30 | 1 | 33,214 | Dennis Rasmussen | Greg Harris | Dennis Rasmussen | Greg Harris | Dave Righetti | 428 | 351 | 77 |
| 1987-07-05 | vs TEX | 82 | L 4-10 | 51-31 | 1 | 34,080 | Rich Bordi | Ed Correa | Jeff Russell | Rich Bordi | | 432 | 361 | 71 |
| 1987-07-06 | vs MIN | 83 | L 0-2 | 51-32 | 1 | 20,141 | Ron Guidry | Frank Viola | Frank Viola | Ron Guidry | | 432 | 363 | 69 |
| 1987-07-07 | vs MIN | 84 | W 12-7 | 52-32 | 1 | 27,697 | Tommy John | Joe Niekro | Tim Stoddard | Keith Atherton | | 444 | 370 | 74 |
| 1987-07-08 | vs MIN | 85 | W 13-4 | 53-32 | 1 | 38,168 | Rick Rhoden | Mike Smithson | Rick Rhoden | Mike Smithson | Pat Clements | 457 | 374 | 83 |
| 1987-07-09 | vs CHA | 86 | L 3-6 | 53-33 | 1 | 26,255 | Bob Tewksbury | Richard Dotson | Richard Dotson | Bob Tewksbury | Bob James | 460 | 380 | 80 |
| 1987-07-10 | vs CHA | 87 | W 9-5 | 54-33 | 1 | 27,123 | Dennis Rasmussen | Scott Nielsen | Dennis Rasmussen | Scott Nielsen | | 469 | 385 | 84 |
| 1987-07-11 | vs CHA | 88 | L 2-5 | 54-34 | 1 | 45,528 | Ron Guidry | Jose DeLeon | Bill Long | Pat Clements | | 471 | 390 | 81 |
| 1987-07-12 | vs CHA | 89 | W 6-2 | 55-34 | 1 | 33,723 | Tommy John | Floyd Bannister | Tommy John | Floyd Bannister | | 477 | 392 | 85 |
| 1987-07-16 | @ TEX | 90 | W 12-3 | 56-34 | 1 | 24,459 | Ron Guidry | Charlie Hough | Ron Guidry | Charlie Hough | | 489 | 395 | 94 |
| 1987-07-17 | @ TEX | 91 | W 8-4 | 57-34 | 1 | 33,977 | Rick Rhoden | Bobby Witt | Rick Rhoden | Bobby Witt | | 497 | 399 | 98 |
| 1987-07-18 | @ TEX | 92 | L 2-7 | 57-35 | 1 | 41,871 | Dennis Rasmussen | Jose Guzman | Jose Guzman | Charles Hudson | | 499 | 406 | 93 |
| 1987-07-19 | @ TEX | 93 | L 3-20 | 57-36 | 1 | 30,875 | Steve Trout | Greg Harris | Greg Harris | Steve Trout | | 502 | 426 | 76 |
| 1987-07-20 | @ MIN | 94 | W 7-1 | 58-36 | 1 | 34,966 | Tommy John | Les Straker | Tommy John | Les Straker | | 509 | 427 | 82 |
| 1987-07-21 | @ MIN | 95 | L 1-2 | 58-37 | 1 | 37,391 | Ron Guidry | Bert Blyleven | Bert Blyleven | Tim Stoddard | | 510 | 429 | 81 |
| 1987-07-22 | @ MIN | 96 | L 1-3 | 58-38 | 1 | 40,054 | Rick Rhoden | Frank Viola | Frank Viola | Rick Rhoden | Jeff Reardon | 511 | 432 | 79 |
| 1987-07-24 | @ CHA | 97 | L 2-5 | 58-39 | 1 | 27,441 | Steve Trout | Floyd Bannister | Floyd Bannister | Steve Trout | Jim Winn | 513 | 437 | 76 |
| 1987-07-25 | @ CHA | 98 | L 2-3 | 58-40 | 1 | 26,433 | Tommy John | Neil Allen | Ray Searage | Pat Clements | Jim Winn | 515 | 440 | 75 |
| 1987-07-26 | @ CHA | 99 | W 5-2 | 59-40 | 1 | 22,762 | Ron Guidry | Richard Dotson | Ron Guidry | Richard Dotson | Dave Righetti | 520 | 442 | 78 |
| 1987-07-28 | vs KCA | 100 | W 2-1 | 60-40 | 1 | 36,813 | Rick Rhoden | Mark Gubicza | Rick Rhoden | Mark Gubicza | | 522 | 443 | 79 |
| 1987-07-29 | vs KCA | 101 | W 4-0 | 61-40 | 1 | 45,131 | Steve Trout | Danny Jackson | Tim Stoddard | Danny Jackson | Dave Righetti | 526 | 443 | 83 |
| 1987-07-30 | vs KCA | 102 | W 6-3 | 62-40 | 1 | 33,117 | Tommy John | Buddy Black | Tommy John | Buddy Black | Tim Stoddard | 532 | 446 | 86 |
| 1987-07-31 | vs DET | 103 | W 6-5 | 63-40 | 1 | 50,214 | Ron Guidry | Walt Terrell | Dave Righetti | Mike Henneman | | 538 | 451 | 87 |
| 1987-08-01 | vs DET | 104 | L 5-10 | 63-41 | 1 | 55,103 | Dennis Rasmussen | Frank Tanana | Frank Tanana | Dennis Rasmussen | | 543 | 461 | 82 |
| 1987-08-02 | vs DET | 105 | W 8-5 | 64-41 | 1 | 46,212 | Rick Rhoden | Jeff Robinson | Rick Rhoden | Jeff Robinson | Dave Righetti | 551 | 466 | 85 |
| 1987-08-03 | @ CLE | 106 | L 0-2 | 64-42 | 1 | 14,587 | Steve Trout | Tom Candiotti | Tom Candiotti | Steve Trout | | 551 | 468 | 83 |
| 1987-08-04 | @ CLE | 107 | L 3-15 | 64-43 | 1 | 15,283 | Tommy John | Ken Schrom | Ken Schrom | Tommy John | | 554 | 483 | 71 |
| 1987-08-05 | @ CLE | 108 | W 5-2 | 65-43 | 1 | 17,670 | Brad Arnsberg | Phil Niekro | Brad Arnsberg | Phil Niekro | Dave Righetti | 559 | 485 | 74 |
| 1987-08-06 | @ DET | 109 | L 5-12 | 65-44 | 1 | 41,875 | Ron Guidry | Frank Tanana | Frank Tanana | Ron Guidry | | 564 | 497 | 67 |
| 1987-08-07 | @ DET | 110 | L 0-8 | 65-45 | 2 | 48,262 | Rick Rhoden | Jeff Robinson | Jeff Robinson | Rick Rhoden | | 564 | 505 | 59 |
| 1987-08-08 | @ DET | 111 | W 7-0 | 66-45 | 1 | 45,812 | Tommy John | Eric King | Tommy John | Eric King | | 571 | 505 | 66 |
| 1987-08-09 | @ DET | 112 | L 4-15 | 66-46 | 2 | 44,673 | Dennis Rasmussen | Dan Petry | Dan Petry | Dennis Rasmussen | | 575 | 520 | 55 |
| 1987-08-10 | @ KCA | 113 | L 1-10 | 66-47 | 2 | 40,729 | Brad Arnsberg | Danny Jackson | Danny Jackson | Brad Arnsberg | | 576 | 530 | 46 |
| 1987-08-11 | @ KCA | 114 | L 5-8 | 66-48 | 3 | 35,651 | Ron Guidry | Bret Saberhagen | Bret Saberhagen | Ron Guidry | Jerry Gleaton | 581 | 538 | 43 |
| 1987-08-12 | @ KCA | 115 | L 1-2 | 66-49 | 3 | 34,395 | Rick Rhoden | Charlie Leibrandt | Charlie Leibrandt | Rick Rhoden | | 582 | 540 | 42 |
| 1987-08-14 | vs CLE | 116 | L 5-6 | 66-50 | 3 | 35,201 | Tommy John | Tom Candiotti | Tom Candiotti | Brad Arnsberg | Doug Jones | 587 | 546 | 41 |
| 1987-08-15 | vs CLE | 117 | W 11-2 | 67-50 | 3 | 38,930 | Dennis Rasmussen | Ken Schrom | Dennis Rasmussen | Ken Schrom | Tim Stoddard | 598 | 548 | 50 |
| 1987-08-16 | vs CLE | 118 | L 0-1 | 67-51 | 3 | 38,807 | Ron Guidry | Rich Yett | Rich Yett | Ron Guidry | Doug Jones | 598 | 549 | 49 |
| 1987-08-18 | @ SEA | 119 | W 4-3 | 68-51 | 3 | 20,039 | Rick Rhoden | Dennis Powell | Tim Stoddard | Bill Wilkinson | Dave Righetti | 602 | 552 | 50 |
| 1987-08-19 | @ SEA | 120 | W 8-0 | 69-51 | 3 | 16,226 | Tommy John | Mike Morgan | Charles Hudson | Mike Morgan | | 610 | 552 | 58 |
| 1987-08-20 | @ SEA | 121 | L 3-4 | 69-52 | 3 | 18,095 | Dennis Rasmussen | Mike Campbell | Jerry Reed | Brad Arnsberg | | 613 | 556 | 57 |
| 1987-08-21 | @ OAK | 122 | L 4-6 | 69-53 | 3 | 35,359 | Ron Guidry | Steve Ontiveros | Steve Ontiveros | Ron Guidry | Jay Howell | 617 | 562 | 55 |
| 1987-08-22 | @ OAK | 123 | L 0-6 | 69-54 | 3 | 40,116 | Steve Trout | Gene Nelson | Gene Nelson | Steve Trout | | 617 | 568 | 49 |
| 1987-08-23 | @ OAK | 124 | W 4-0 | 70-54 | 3 | 43,726 | Rick Rhoden | Dave Stewart | Rick Rhoden | Dave Stewart | Tim Stoddard | 621 | 568 | 53 |
| 1987-08-24 | @ CAL | 125 | W 3-2 | 71-54 | 3 | 38,742 | Tommy John | Don Sutton | Charles Hudson | Gary Lucas | Dave Righetti | 624 | 570 | 54 |
| 1987-08-25 | @ CAL | 126 | L 1-5 | 71-55 | 3 | 43,905 | Dennis Rasmussen | John Candelaria | John Candelaria | Dennis Rasmussen | | 625 | 575 | 50 |
| 1987-08-28 | vs SEA | 127 | L 4-10 | 71-56 | 3 | 22,095 | Steve Trout | Dennis Powell | Mike Trujillo | Charles Hudson | | 629 | 585 | 44 |
| 1987-08-29 | vs SEA | 128 | L 1-7 | 72-57 | 3 | 0 | Rick Rhoden | Mark Langston | Mark Langston | Rick Rhoden | | 630 | 592 | 38 |
| 1987-08-29 | vs SEA | 129 | W 4-2 | 72-57 | 3 | 37,276 | Tommy John | Mike Campbell | Tommy John | Mike Campbell | Dave Righetti | 634 | 594 | 40 |
| 1987-08-30 | vs SEA | 130 | W 4-1 | 73-57 | 3 | 37,854 | Bill Gullickson | Mike Moore | Bill Gullickson | Mike Moore | Dave Righetti | 638 | 595 | 43 |
| 1987-08-31 | vs OAK | 131 | W 4-1 | 74-57 | 3 | 25,597 | Ron Guidry | Curt Young | Ron Guidry | Curt Young | Tim Stoddard | 642 | 596 | 46 |
| 1987-09-01 | vs OAK | 132 | L 3-8 | 74-58 | 3 | 31,170 | Charles Hudson | Steve Ontiveros | Steve Ontiveros | Charles Hudson | | 645 | 604 | 41 |
| 1987-09-02 | vs OAK | 133 | W 3-2 | 75-58 | 3 | 33,619 | Tommy John | Dave Stewart | Dave Righetti | Rick Honeycutt | | 648 | 606 | 42 |
| 1987-09-04 | vs CAL | 134 | W 8-4 | 76-58 | 3 | 24,135 | Bill Gullickson | Kirk McCaskill | Bill Gullickson | Kirk McCaskill | Pat Clements | 656 | 610 | 46 |
| 1987-09-05 | vs CAL | 135 | W 7-6 | 77-58 | 3 | 31,566 | Ron Guidry | Don Sutton | Ron Guidry | Don Sutton | Dave Righetti | 663 | 616 | 47 |
| 1987-09-06 | vs CAL | 136 | L 1-3 | 77-59 | 3 | 48,214 | Tommy John | John Candelaria | John Candelaria | Tommy John | DeWayne Buice | 664 | 619 | 45 |
| 1987-09-07 | @ BOS | 137 | W 9-5 | 78-59 | 3 | 32,544 | Rick Rhoden | Bruce Hurst | Rick Rhoden | Bruce Hurst | Tim Stoddard | 673 | 624 | 49 |
| 1987-09-08 | @ BOS | 138 | L 6-8 | 78-60 | 3 | 29,468 | Bill Gullickson | Al Nipper | Al Nipper | Bill Gullickson | Calvin Schiraldi | 679 | 632 | 47 |
| 1987-09-09 | @ BOS | 139 | L 3-5 | 78-61 | 3 | 32,025 | Charles Hudson | Roger Clemens | Roger Clemens | Charles Hudson | | 682 | 637 | 45 |
| 1987-09-11 | @ TOR | 140 | L 5-6 | 78-62 | 3 | 38,540 | Tommy John | Mike Flanagan | David Wells | Dave Righetti | | 687 | 643 | 44 |
| 1987-09-12 | @ TOR | 141 | L 1-13 | 78-63 | 4 | 45,648 | Rick Rhoden | Jimmy Key | Jimmy Key | Rick Rhoden | | 688 | 656 | 32 |
| 1987-09-13 | @ TOR | 142 | W 8-5 | 79-63 | 3 | 45,312 | Steve Trout | John Cerutti | Charles Hudson | John Cerutti | Dave Righetti | 696 | 661 | 35 |
| 1987-09-14 | vs MIL | 143 | L 4-6 | 79-64 | 4 | 20,211 | Bill Gullickson | Len Barker | Dave Stapleton | Bill Gullickson | Mark Clear | 700 | 667 | 33 |
| 1987-09-15 | vs MIL | 144 | W 4-3 | 80-64 | 3 | 22,102 | Al Leiter | Juan Nieves | Al Leiter | Juan Nieves | Dave Righetti | 704 | 670 | 34 |
| 1987-09-16 | vs MIL | 145 | L 4-5 | 80-65 | 4 | 20,232 | Tommy John | Teddy Higuera | Teddy Higuera | Tim Stoddard | | 708 | 675 | 33 |
| 1987-09-17 | vs TOR | 146 | W 6-5 | 81-65 | 4 | 27,032 | Steve Trout | John Cerutti | Dave Righetti | Tom Henke | | 714 | 680 | 34 |
| 1987-09-18 | vs TOR | 147 | L 3-6 | 81-66 | 4 | 34,110 | Neil Allen | Jim Clancy | Jim Clancy | Neil Allen | David Wells | 717 | 686 | 31 |
| 1987-09-19 | vs TOR | 148 | W 4-2 | 82-66 | 3 | 38,239 | Bill Gullickson | Mike Flanagan | Bill Gullickson | Mike Flanagan | Dave Righetti | 721 | 688 | 33 |
| 1987-09-20 | vs TOR | 149 | L 2-6 | 82-67 | 4 | 45,267 | Al Leiter | Jimmy Key | David Wells | Al Leiter | | 723 | 694 | 29 |
| 1987-09-22 | @ MIL | 150 | L 2-7 | 83-68 | 4 | 0 | Tommy John | Teddy Higuera | Teddy Higuera | Tommy John | Paul Mirabella | 725 | 701 | 24 |
| 1987-09-22 | @ MIL | 151 | W 10-8 | 83-68 | 4 | 12,651 | Steve Trout | Len Barker | Pat Clements | Chuck Crim | Dave Righetti | 735 | 709 | 26 |
| 1987-09-23 | @ MIL | 152 | L 7-8 | 83-69 | 4 | 11,219 | Bill Gullickson | Bill Wegman | Chuck Crim | Dave Righetti | | 742 | 717 | 25 |
| 1987-09-25 | @ BAL | 153 | W 8-4 | 84-69 | 4 | 29,351 | Al Leiter | Jose Mesa | Al Leiter | Jose Mesa | Pat Clements | 750 | 721 | 29 |
| 1987-09-26 | @ BAL | 154 | W 2-0 | 85-69 | 4 | 26,608 | Pete Filson | Mike Boddicker | Pete Filson | Mike Boddicker | Dave Righetti | 752 | 721 | 31 |
| 1987-09-27 | @ BAL | 155 | L 5-9 | 85-70 | 4 | 28,191 | Tommy John | Jeff Ballard | Jack O'Connor | Pat Clements | Tom Niedenfuer | 757 | 730 | 27 |
| 1987-09-28 | vs BOS | 156 | W 9-7 | 86-70 | 4 | 20,320 | Bill Gullickson | Rob Woodward | Bill Fulton | Joe Sambito | | 766 | 737 | 29 |
| 1987-09-29 | vs BOS | 157 | W 6-0 | 87-70 | 4 | 20,204 | Charles Hudson | Bruce Hurst | Charles Hudson | Bruce Hurst | | 772 | 737 | 35 |
| 1987-09-30 | vs BOS | 158 | L 0-7 | 87-71 | 4 | 20,280 | Al Leiter | Roger Clemens | Roger Clemens | Al Leiter | | 772 | 744 | 28 |
| 1987-10-01 | vs BOS | 159 | L 5-7 | 87-72 | 4 | 20,176 | Pete Filson | Al Nipper | Al Nipper | Dave Righetti | | 777 | 751 | 26 |
| 1987-10-02 | vs BAL | 160 | W 3-1 | 88-72 | 4 | 18,943 | Tommy John | Jeff Ballard | Tommy John | Jeff Ballard | | 780 | 752 | 28 |
| 1987-10-03 | vs BAL | 161 | W 6-2 | 89-72 | 4 | 21,556 | Bill Gullickson | John Habyan | Bill Gullickson | John Habyan | Pat Clements | 786 | 754 | 32 |
| 1987-10-04 | vs BAL | 162 | L 2-4 | 89-73 | 4 | 25,101 | Charles Hudson | Eric Bell | Eric Bell | Charles Hudson | Tom Niedenfuer | 788 | 758 | 30 |