| 1987-04-06 | vs CHA | 1 | L 4-5 | 0-1 | 2 | 39,148 | Danny Jackson | Richard Dotson | Richard Dotson | Danny Jackson | Bob James | 4 | 5 | -1 |
| 1987-04-08 | vs CHA | 2 | W 9-3 | 1-1 | 4 | 19,446 | Charlie Leibrandt | Floyd Bannister | Charlie Leibrandt | Floyd Bannister | | 13 | 8 | 5 |
| 1987-04-09 | vs CHA | 3 | L 0-6 | 1-2 | 4 | 21,419 | Mark Gubicza | Jose DeLeon | Jose DeLeon | Mark Gubicza | Bobby Thigpen | 13 | 14 | -1 |
| 1987-04-10 | vs NYA | 4 | W 13-1 | 2-2 | 4 | 28,632 | Bret Saberhagen | Rick Rhoden | Bret Saberhagen | Rick Rhoden | | 26 | 15 | 11 |
| 1987-04-11 | vs NYA | 5 | L 2-15 | 2-3 | 4 | 31,303 | Danny Jackson | Dennis Rasmussen | Dennis Rasmussen | Danny Jackson | | 28 | 30 | -2 |
| 1987-04-12 | vs NYA | 6 | W 8-2 | 3-3 | 3 | 28,154 | Charlie Leibrandt | Joe Niekro | Charlie Leibrandt | Joe Niekro | | 36 | 32 | 4 |
| 1987-04-14 | vs DET | 7 | W 10-1 | 4-3 | 3 | 16,023 | Mark Gubicza | Dan Petry | Mark Gubicza | Dan Petry | | 46 | 33 | 13 |
| 1987-04-15 | vs DET | 8 | W 2-1 | 5-3 | 3 | 18,721 | Bret Saberhagen | Walt Terrell | Bret Saberhagen | Walt Terrell | Buddy Black | 48 | 34 | 14 |
| 1987-04-18 | @ NYA | 9 | L 6-7 | 5-4 | 3 | 22,053 | Danny Jackson | Dennis Rasmussen | Dave Righetti | Steve Farr | | 54 | 41 | 13 |
| 1987-04-19 | @ NYA | 10 | L 0-5 | 5-6 | 4 | 0 | Charlie Leibrandt | Charles Hudson | Charles Hudson | Charlie Leibrandt | | 54 | 46 | 8 |
| 1987-04-19 | @ NYA | 11 | L 0-1 | 5-6 | 4 | 40,939 | Mark Gubicza | Tommy John | Pat Clements | Mark Gubicza | Dave Righetti | 54 | 47 | 7 |
| 1987-04-20 | @ BOS | 12 | W 10-2 | 6-6 | 3 | 35,486 | Bret Saberhagen | Bruce Hurst | Bret Saberhagen | Bruce Hurst | | 64 | 49 | 15 |
| 1987-04-21 | @ BOS | 13 | L 0-8 | 6-7 | 3 | 29,082 | Rick Anderson | Roger Clemens | Roger Clemens | Rick Anderson | | 64 | 57 | 7 |
| 1987-04-22 | @ BOS | 14 | L 0-1 | 6-8 | 4 | 24,589 | Danny Jackson | Bob Stanley | Bob Stanley | Danny Jackson | | 64 | 58 | 6 |
| 1987-04-24 | @ DET | 15 | W 7-3 | 7-8 | 4 | 14,449 | Charlie Leibrandt | Dan Petry | Charlie Leibrandt | Dan Petry | | 71 | 61 | 10 |
| 1987-04-25 | @ DET | 16 | L 2-13 | 7-9 | 4 | 18,052 | Mark Gubicza | Jack Morris | Jack Morris | Mark Gubicza | | 73 | 74 | -1 |
| 1987-04-26 | @ DET | 17 | W 6-1 | 8-9 | 4 | 16,686 | Bret Saberhagen | Walt Terrell | Bret Saberhagen | Walt Terrell | | 79 | 75 | 4 |
| 1987-04-28 | vs BAL | 18 | L 0-3 | 8-10 | 4 | 24,894 | Danny Jackson | Mike Boddicker | Mike Boddicker | Danny Jackson | | 79 | 78 | 1 |
| 1987-04-29 | vs BAL | 19 | W 5-4 | 9-10 | 4 | 21,593 | Charlie Leibrandt | Eric Bell | Dan Quisenberry | Dave J. Schmidt | | 84 | 82 | 2 |
| 1987-05-01 | vs CLE | 20 | L 0-2 | 9-11 | 4 | 27,281 | Mark Gubicza | Phil Niekro | Phil Niekro | Mark Gubicza | Rich Yett | 84 | 84 | 0 |
| 1987-05-02 | vs CLE | 21 | W 5-4 | 10-11 | 4 | 29,548 | Bret Saberhagen | Scott Bailes | Bret Saberhagen | Rich Yett | Dan Quisenberry | 89 | 88 | 1 |
| 1987-05-03 | vs CLE | 22 | W 2-1 | 11-11 | 3 | 27,829 | Danny Jackson | Ken Schrom | Danny Jackson | Ken Schrom | | 91 | 89 | 2 |
| 1987-05-05 | vs TOR | 23 | W 6-4 | 12-11 | 3 | 19,245 | Charlie Leibrandt | Joe Johnson | Charlie Leibrandt | Joe Johnson | Jerry Gleaton | 97 | 93 | 4 |
| 1987-05-06 | vs TOR | 24 | W 6-3 | 13-11 | 2 | 28,083 | Buddy Black | Jimmy Key | Buddy Black | Jimmy Key | Jerry Gleaton | 103 | 96 | 7 |
| 1987-05-08 | @ CLE | 25 | W 9-6 | 14-11 | 1 | 32,720 | Mark Gubicza | Ken Schrom | Mark Gubicza | Ken Schrom | Dan Quisenberry | 112 | 102 | 10 |
| 1987-05-09 | @ CLE | 26 | W 4-0 | 15-11 | 1 | 12,051 | Bret Saberhagen | Tom Candiotti | Bret Saberhagen | Tom Candiotti | | 116 | 102 | 14 |
| 1987-05-10 | @ CLE | 27 | L 2-4 | 15-12 | 1 | 14,430 | Danny Jackson | Greg Swindell | Greg Swindell | Danny Jackson | | 118 | 106 | 12 |
| 1987-05-11 | @ TOR | 28 | L 0-4 | 15-13 | 4 | 24,154 | Charlie Leibrandt | Jimmy Key | Jimmy Key | Charlie Leibrandt | | 118 | 110 | 8 |
| 1987-05-12 | @ TOR | 29 | W 3-1 | 16-13 | 1 | 30,034 | Buddy Black | John Cerutti | Buddy Black | John Cerutti | Dan Quisenberry | 121 | 111 | 10 |
| 1987-05-13 | @ BAL | 30 | W 8-7 | 17-13 | 1 | 18,457 | Mark Gubicza | Mike Boddicker | Steve Farr | Mark Williamson | | 129 | 118 | 11 |
| 1987-05-14 | @ BAL | 31 | L 3-4 | 17-14 | 2 | 17,926 | Bret Saberhagen | Jeff Ballard | Dave J. Schmidt | Bret Saberhagen | Ken Dixon | 132 | 122 | 10 |
| 1987-05-15 | vs MIL | 32 | W 4-3 | 18-14 | 1 | 38,532 | Danny Jackson | Juan Nieves | Dan Quisenberry | Mark Clear | | 136 | 125 | 11 |
| 1987-05-16 | vs MIL | 33 | W 13-0 | 19-14 | 1 | 40,092 | Charlie Leibrandt | Bill Wegman | Charlie Leibrandt | Bill Wegman | | 149 | 125 | 24 |
| 1987-05-17 | vs MIL | 34 | W 3-2 | 20-14 | 1 | 35,724 | Buddy Black | Mike Birkbeck | Steve Farr | Mike Birkbeck | Jerry Gleaton | 152 | 127 | 25 |
| 1987-05-18 | vs BOS | 35 | W 4-2 | 21-14 | 1 | 34,110 | Mark Gubicza | Al Nipper | Mark Gubicza | Al Nipper | Dan Quisenberry | 156 | 129 | 27 |
| 1987-05-19 | vs BOS | 36 | W 4-1 | 22-14 | 1 | 25,340 | Bret Saberhagen | Bob Stanley | Bret Saberhagen | Bob Stanley | | 160 | 130 | 30 |
| 1987-05-20 | vs BOS | 37 | L 1-7 | 22-15 | 1 | 24,168 | Danny Jackson | Bruce Hurst | Bruce Hurst | Danny Jackson | | 161 | 137 | 24 |
| 1987-05-22 | @ TEX | 38 | W 8-1 | 23-15 | 1 | 28,609 | Charlie Leibrandt | Mike Loynd | Charlie Leibrandt | Mike Loynd | | 169 | 138 | 31 |
| 1987-05-23 | @ TEX | 39 | L 4-6 | 23-16 | 1 | 35,133 | Buddy Black | Charlie Hough | Charlie Hough | Buddy Black | | 173 | 144 | 29 |
| 1987-05-24 | @ TEX | 40 | W 5-2 | 24-16 | 1 | 38,952 | Mark Gubicza | Jose Guzman | Jerry Gleaton | Jose Guzman | Dan Quisenberry | 178 | 146 | 32 |
| 1987-05-25 | @ CHA | 41 | W 6-1 | 25-16 | 1 | 11,259 | Bret Saberhagen | Joel Davis | Bret Saberhagen | Joel Davis | | 184 | 147 | 37 |
| 1987-05-26 | @ CHA | 42 | W 5-4 | 26-16 | 1 | 13,343 | Danny Jackson | Bill Long | Danny Jackson | Bill Long | Dan Quisenberry | 189 | 151 | 38 |
| 1987-05-27 | @ CHA | 43 | L 2-3 | 26-17 | 1 | 15,803 | Charlie Leibrandt | Richard Dotson | Richard Dotson | Charlie Leibrandt | Bob James | 191 | 154 | 37 |
| 1987-05-29 | vs TEX | 44 | L 5-16 | 26-18 | 1 | 31,849 | Mark Gubicza | Charlie Hough | Charlie Hough | Mark Gubicza | | 196 | 170 | 26 |
| 1987-05-30 | vs TEX | 45 | W 12-7 | 27-18 | 1 | 38,513 | Bret Saberhagen | Jose Guzman | Bret Saberhagen | Jose Guzman | Steve Farr | 208 | 177 | 31 |
| 1987-05-31 | vs TEX | 46 | L 2-3 | 27-19 | 1 | 36,349 | Danny Jackson | Ed Correa | Dale Mohorcic | Jerry Gleaton | | 210 | 180 | 30 |
| 1987-06-01 | @ MIL | 47 | L 2-3 | 27-20 | 1 | 9,670 | Charlie Leibrandt | Bill Wegman | Bill Wegman | Charlie Leibrandt | Dan Plesac | 212 | 183 | 29 |
| 1987-06-02 | @ MIL | 48 | L 3-14 | 27-21 | 1 | 12,240 | Buddy Black | Chuck Crim | Chuck Crim | Buddy Black | Mark Clear | 215 | 197 | 18 |
| 1987-06-03 | @ MIL | 49 | L 2-4 | 27-22 | 1 | 17,740 | Mark Gubicza | Len Barker | Len Barker | Mark Gubicza | Dan Plesac | 217 | 201 | 16 |
| 1987-06-04 | @ SEA | 50 | W 6-1 | 28-22 | 1 | 12,153 | Bret Saberhagen | Mike Morgan | Bret Saberhagen | Mike Morgan | | 223 | 202 | 21 |
| 1987-06-05 | @ SEA | 51 | L 2-7 | 28-23 | 1 | 21,671 | Danny Jackson | Lee Guetterman | Lee Guetterman | Danny Jackson | Steve Shields | 225 | 209 | 16 |
| 1987-06-06 | @ SEA | 52 | W 5-2 | 29-23 | 1 | 25,083 | Charlie Leibrandt | Scott Bankhead | Charlie Leibrandt | Scott Bankhead | Dan Quisenberry | 230 | 211 | 19 |
| 1987-06-07 | @ SEA | 53 | W 9-1 | 30-23 | 1 | 12,859 | Buddy Black | Mike Moore | Buddy Black | Mike Moore | | 239 | 212 | 27 |
| 1987-06-08 | @ MIN | 54 | L 3-5 | 30-24 | 1 | 17,815 | Mark Gubicza | Mike Smithson | Randy Niemann | Mark Gubicza | Jeff Reardon | 242 | 217 | 25 |
| 1987-06-09 | @ MIN | 55 | L 2-5 | 30-25 | 1 | 18,563 | Danny Jackson | Joe Niekro | Joe Niekro | Danny Jackson | Keith Atherton | 244 | 222 | 22 |
| 1987-06-10 | @ MIN | 56 | L 3-4 | 30-26 | 2 | 18,560 | Charlie Leibrandt | Bert Blyleven | Jeff Reardon | Jerry Gleaton | | 247 | 226 | 21 |
| 1987-06-12 | vs CAL | 57 | W 1-0 | 31-26 | 2 | 35,415 | Bret Saberhagen | Mike Witt | Bret Saberhagen | Mike Witt | | 248 | 226 | 22 |
| 1987-06-13 | vs CAL | 58 | L 0-4 | 31-27 | 3 | 39,650 | Mark Gubicza | Willie Fraser | Willie Fraser | Mark Gubicza | | 248 | 230 | 18 |
| 1987-06-14 | vs CAL | 59 | L 0-12 | 31-28 | 3 | 29,260 | Danny Jackson | Don Sutton | Don Sutton | Danny Jackson | | 248 | 242 | 6 |
| 1987-06-15 | vs OAK | 60 | L 6-7 | 31-29 | 3 | 36,157 | Charlie Leibrandt | Curt Young | Dave Leiper | Steve Farr | Jay Howell | 254 | 249 | 5 |
| 1987-06-16 | vs OAK | 61 | L 1-11 | 31-30 | 3 | 26,562 | Rick Anderson | Steve Ontiveros | Steve Ontiveros | Rick Anderson | | 255 | 260 | -5 |
| 1987-06-17 | vs OAK | 62 | W 10-5 | 32-30 | 3 | 26,780 | Bret Saberhagen | Dave Stewart | Bret Saberhagen | Dave Stewart | | 265 | 265 | 0 |
| 1987-06-18 | @ CAL | 63 | W 10-4 | 33-30 | 3 | 42,923 | Mark Gubicza | Willie Fraser | Mark Gubicza | Willie Fraser | | 275 | 269 | 6 |
| 1987-06-19 | @ CAL | 64 | W 2-0 | 34-30 | 2 | 32,797 | Danny Jackson | Don Sutton | Danny Jackson | Don Sutton | | 277 | 269 | 8 |
| 1987-06-20 | @ CAL | 65 | W 8-4 | 35-30 | 2 | 39,510 | Charlie Leibrandt | Jack Lazorko | Charlie Leibrandt | Jack Lazorko | | 285 | 273 | 12 |
| 1987-06-21 | @ CAL | 66 | L 0-8 | 35-31 | 2 | 47,797 | Bob Stoddard | Jerry Reuss | Jerry Reuss | Bob Stoddard | | 285 | 281 | 4 |
| 1987-06-22 | @ OAK | 67 | L 1-4 | 35-32 | 3 | 18,346 | Bret Saberhagen | Steve Ontiveros | Steve Ontiveros | Bret Saberhagen | Jay Howell | 286 | 285 | 1 |
| 1987-06-23 | @ OAK | 68 | W 4-0 | 36-32 | 2 | 13,121 | Mark Gubicza | Jose Rijo | Mark Gubicza | Jose Rijo | | 290 | 285 | 5 |
| 1987-06-24 | @ OAK | 69 | L 2-4 | 36-33 | 3 | 18,123 | Danny Jackson | Curt Young | Curt Young | Danny Jackson | Dennis Eckersley | 292 | 289 | 3 |
| 1987-06-26 | vs SEA | 70 | L 1-5 | 36-34 | 4 | 39,299 | Charlie Leibrandt | Mike Morgan | Mike Morgan | Charlie Leibrandt | Bill Wilkinson | 293 | 294 | -1 |
| 1987-06-27 | vs SEA | 71 | W 6-0 | 37-34 | 3 | 39,447 | Bret Saberhagen | Lee Guetterman | Bret Saberhagen | Lee Guetterman | | 299 | 294 | 5 |
| 1987-06-28 | vs SEA | 72 | W 8-3 | 38-34 | 3 | 32,634 | Mark Gubicza | Mike Moore | Mark Gubicza | Mike Moore | | 307 | 297 | 10 |
| 1987-06-29 | vs MIN | 73 | W 3-2 | 39-34 | 3 | 35,872 | Danny Jackson | Les Straker | Danny Jackson | Les Straker | | 310 | 299 | 11 |
| 1987-06-30 | vs MIN | 74 | L 1-3 | 39-35 | 3 | 21,515 | Charlie Leibrandt | Bert Blyleven | Bert Blyleven | Charlie Leibrandt | Jeff Reardon | 311 | 302 | 9 |
| 1987-07-01 | vs MIN | 75 | W 4-3 | 40-35 | 2 | 26,899 | Bob Stoddard | Frank Viola | Dan Quisenberry | Keith Atherton | | 315 | 305 | 10 |
| 1987-07-02 | vs MIN | 76 | W 10-3 | 41-35 | 2 | 35,992 | Bret Saberhagen | Joe Niekro | Bret Saberhagen | Joe Niekro | | 325 | 308 | 17 |
| 1987-07-03 | vs TOR | 77 | W 6-4 | 43-35 | 1 | 0 | Mark Gubicza | Jim Clancy | Mark Gubicza | Jim Clancy | Jerry Gleaton | 331 | 312 | 19 |
| 1987-07-03 | vs TOR | 78 | W 5-4 | 43-35 | 1 | 40,619 | Danny Jackson | John Cerutti | Steve Farr | Tom Henke | | 336 | 316 | 20 |
| 1987-07-04 | vs TOR | 79 | W 9-1 | 44-35 | 1 | 40,746 | Buddy Black | David Wells | Buddy Black | David Wells | Bob Stoddard | 345 | 317 | 28 |
| 1987-07-05 | vs TOR | 80 | W 4-3 | 45-35 | 1 | 25,607 | Charlie Leibrandt | Dave Stieb | Dan Quisenberry | Mark Eichhorn | | 349 | 320 | 29 |
| 1987-07-06 | @ CLE | 81 | L 7-9 | 45-36 | 2 | 6,332 | Bret Saberhagen | Steve Carlton | Sammy Stewart | Bret Saberhagen | Mark Huismann | 356 | 329 | 27 |
| 1987-07-07 | @ CLE | 82 | L 4-6 | 45-37 | 2 | 8,012 | Mark Gubicza | Ken Schrom | Doug Jones | Dan Quisenberry | | 360 | 335 | 25 |
| 1987-07-08 | @ CLE | 83 | L 8-9 | 45-38 | 2 | 9,528 | Danny Jackson | Tom Candiotti | Sammy Stewart | Jerry Gleaton | | 368 | 344 | 24 |
| 1987-07-09 | @ TOR | 84 | L 1-7 | 45-39 | 2 | 31,290 | Buddy Black | Jose Nunez | Jose Nunez | Buddy Black | | 369 | 351 | 18 |
| 1987-07-10 | @ TOR | 85 | L 0-7 | 45-40 | 2 | 35,200 | Charlie Leibrandt | Dave Stieb | Dave Stieb | Charlie Leibrandt | | 369 | 358 | 11 |
| 1987-07-11 | @ TOR | 86 | W 2-1 | 46-40 | 2 | 38,289 | Bret Saberhagen | Jimmy Key | Bret Saberhagen | Jimmy Key | | 371 | 359 | 12 |
| 1987-07-12 | @ TOR | 87 | L 2-3 | 46-41 | 2 | 40,268 | Mark Gubicza | Jim Clancy | Jim Clancy | Buddy Black | Tom Henke | 373 | 362 | 11 |
| 1987-07-16 | vs BAL | 88 | L 4-5 | 46-42 | 3 | 39,036 | Charlie Leibrandt | Mike Boddicker | Mike Boddicker | Charlie Leibrandt | Tom Niedenfuer | 377 | 367 | 10 |
| 1987-07-17 | vs BAL | 89 | L 1-3 | 46-43 | 3 | 38,059 | Mark Gubicza | Eric Bell | Eric Bell | Mark Gubicza | Tom Niedenfuer | 378 | 370 | 8 |
| 1987-07-18 | vs BAL | 90 | L 7-11 | 46-44 | 3 | 38,944 | Danny Jackson | Mike Flanagan | Mike Flanagan | Danny Jackson | | 385 | 381 | 4 |
| 1987-07-19 | vs BAL | 91 | L 1-5 | 46-45 | 4 | 38,055 | Buddy Black | Dave J. Schmidt | Dave J. Schmidt | Buddy Black | | 386 | 386 | 0 |
| 1987-07-20 | vs CLE | 92 | L 5-9 | 46-46 | 4 | 35,164 | Bret Saberhagen | Phil Niekro | Phil Niekro | Bret Saberhagen | Doug Jones | 391 | 395 | -4 |
| 1987-07-21 | vs CLE | 93 | W 3-2 | 47-46 | 4 | 26,880 | Charlie Leibrandt | Scott Bailes | Charlie Leibrandt | Scott Bailes | | 394 | 397 | -3 |
| 1987-07-22 | vs CLE | 94 | W 5-1 | 48-46 | 4 | 24,570 | Mark Gubicza | Darrel Akerfelds | Mark Gubicza | Darrel Akerfelds | | 399 | 398 | 1 |
| 1987-07-23 | @ BAL | 95 | L 1-2 | 48-47 | 4 | 34,535 | Danny Jackson | Eric Bell | Eric Bell | Danny Jackson | | 400 | 400 | 0 |
| 1987-07-24 | @ BAL | 96 | L 1-3 | 48-48 | 4 | 41,687 | Buddy Black | Mike Flanagan | Tom Niedenfuer | Steve Farr | | 401 | 403 | -2 |
| 1987-07-25 | @ BAL | 97 | L 3-4 | 48-49 | 4 | 36,472 | Bret Saberhagen | Dave J. Schmidt | Mark Williamson | Bret Saberhagen | Tom Niedenfuer | 404 | 407 | -3 |
| 1987-07-26 | @ BAL | 98 | W 4-0 | 49-49 | 4 | 28,478 | Charlie Leibrandt | Ken Dixon | Charlie Leibrandt | Ken Dixon | | 408 | 407 | 1 |
| 1987-07-28 | @ NYA | 99 | L 1-2 | 49-50 | 4 | 36,813 | Mark Gubicza | Rick Rhoden | Rick Rhoden | Mark Gubicza | | 409 | 409 | 0 |
| 1987-07-29 | @ NYA | 100 | L 0-4 | 49-51 | 4 | 45,131 | Danny Jackson | Steve Trout | Tim Stoddard | Danny Jackson | Dave Righetti | 409 | 413 | -4 |
| 1987-07-30 | @ NYA | 101 | L 3-6 | 49-52 | 5 | 33,117 | Buddy Black | Tommy John | Tommy John | Buddy Black | Tim Stoddard | 412 | 419 | -7 |
| 1987-07-31 | vs BOS | 102 | L 0-4 | 49-53 | 5 | 40,149 | Bret Saberhagen | Roger Clemens | Roger Clemens | Bret Saberhagen | | 412 | 423 | -11 |
| 1987-08-01 | vs BOS | 103 | W 4-0 | 50-53 | 4 | 40,111 | Charlie Leibrandt | Jeff Sellers | Charlie Leibrandt | Jeff Sellers | | 416 | 423 | -7 |
| 1987-08-02 | vs BOS | 104 | W 13-5 | 51-53 | 4 | 29,154 | Mark Gubicza | Bob Stanley | Mark Gubicza | Bob Stanley | | 429 | 428 | 1 |
| 1987-08-03 | @ DET | 105 | W 4-2 | 52-53 | 4 | 25,781 | Buddy Black | Jack Morris | Jerry Gleaton | Jack Morris | | 433 | 430 | 3 |
| 1987-08-04 | @ DET | 106 | W 8-4 | 53-53 | 4 | 23,330 | Danny Jackson | Dan Petry | Danny Jackson | Dan Petry | | 441 | 434 | 7 |
| 1987-08-05 | @ DET | 107 | L 2-4 | 53-54 | 4 | 21,584 | Bret Saberhagen | Walt Terrell | Walt Terrell | Bret Saberhagen | | 443 | 438 | 5 |
| 1987-08-07 | @ BOS | 108 | L 3-4 | 53-55 | 4 | 34,946 | Charlie Leibrandt | Jeff Sellers | Jeff Sellers | Charlie Leibrandt | | 446 | 442 | 4 |
| 1987-08-08 | @ BOS | 109 | L 3-8 | 53-56 | 5 | 34,622 | Mark Gubicza | Bruce Hurst | Bruce Hurst | Mark Gubicza | | 449 | 450 | -1 |
| 1987-08-09 | @ BOS | 110 | W 8-3 | 54-56 | 4 | 34,009 | Buddy Black | Rob Woodward | John Davis | Steve Crawford | | 457 | 453 | 4 |
| 1987-08-10 | vs NYA | 111 | W 10-1 | 55-56 | 4 | 40,729 | Danny Jackson | Brad Arnsberg | Danny Jackson | Brad Arnsberg | | 467 | 454 | 13 |
| 1987-08-11 | vs NYA | 112 | W 8-5 | 56-56 | 4 | 35,651 | Bret Saberhagen | Ron Guidry | Bret Saberhagen | Ron Guidry | Jerry Gleaton | 475 | 459 | 16 |
| 1987-08-12 | vs NYA | 113 | W 2-1 | 57-56 | 3 | 34,395 | Charlie Leibrandt | Rick Rhoden | Charlie Leibrandt | Rick Rhoden | | 477 | 460 | 17 |
| 1987-08-13 | vs DET | 114 | L 1-4 | 57-57 | 3 | 38,221 | Mark Gubicza | Jack Morris | Jack Morris | Mark Gubicza | | 478 | 464 | 14 |
| 1987-08-14 | vs DET | 115 | W 7-5 | 58-57 | 3 | 38,749 | Buddy Black | Walt Terrell | Buddy Black | Walt Terrell | Dan Quisenberry | 485 | 469 | 16 |
| 1987-08-15 | vs DET | 116 | L 4-8 | 58-58 | 4 | 40,425 | Danny Jackson | Doyle Alexander | Eric King | Danny Jackson | Mike Henneman | 489 | 477 | 12 |
| 1987-08-16 | vs DET | 117 | L 6-10 | 58-59 | 4 | 33,006 | Bret Saberhagen | Frank Tanana | Jeff Robinson | Jerry Gleaton | | 495 | 487 | 8 |
| 1987-08-17 | @ TEX | 118 | W 7-6 | 59-59 | 4 | 24,101 | Charlie Leibrandt | Paul Kilgus | John Davis | Jeff Russell | | 502 | 493 | 9 |
| 1987-08-18 | @ TEX | 119 | L 1-3 | 59-60 | 4 | 23,070 | Mark Gubicza | Charlie Hough | Charlie Hough | Mark Gubicza | | 503 | 496 | 7 |
| 1987-08-19 | @ TEX | 120 | W 11-6 | 60-60 | 3 | 24,588 | Buddy Black | Bobby Witt | Bob Stoddard | Bobby Witt | John Davis | 514 | 502 | 12 |
| 1987-08-21 | @ MIL | 121 | L 0-3 | 60-61 | 3 | 37,141 | Danny Jackson | Len Barker | Len Barker | Danny Jackson | Chuck Crim | 514 | 505 | 9 |
| 1987-08-22 | @ MIL | 122 | W 8-7 | 61-61 | 3 | 37,740 | Bret Saberhagen | Bill Wegman | Jerry Gleaton | Mark Knudson | | 522 | 512 | 10 |
| 1987-08-23 | @ MIL | 123 | L 5-10 | 61-62 | 4 | 33,887 | Charlie Leibrandt | Chris Bosio | Jay Aldrich | Bob Stoddard | | 527 | 522 | 5 |
| 1987-08-24 | vs TEX | 124 | L 2-4 | 61-63 | 4 | 27,042 | Mark Gubicza | Bobby Witt | Bobby Witt | Mark Gubicza | Mitch Williams | 529 | 526 | 3 |
| 1987-08-25 | vs TEX | 125 | L 8-15 | 61-64 | 4 | 21,037 | Buddy Black | Jose Guzman | Steve Howe | Bob Stoddard | | 537 | 541 | -4 |
| 1987-08-26 | vs TEX | 126 | W 3-0 | 62-64 | 4 | 22,398 | Danny Jackson | Charlie Hough | Danny Jackson | Charlie Hough | | 540 | 541 | -1 |
| 1987-08-27 | vs TEX | 127 | W 3-2 | 63-64 | 3 | 28,044 | Bret Saberhagen | Paul Kilgus | John Davis | Dale Mohorcic | | 543 | 543 | 0 |
| 1987-08-28 | @ CHA | 128 | W 9-3 | 64-64 | 3 | 13,484 | Charlie Leibrandt | Dave LaPoint | Charlie Leibrandt | Dave LaPoint | | 552 | 546 | 6 |
| 1987-08-29 | @ CHA | 129 | L 2-7 | 64-65 | 3 | 21,093 | Mark Gubicza | Floyd Bannister | Floyd Bannister | Mark Gubicza | | 554 | 553 | 1 |
| 1987-08-30 | @ CHA | 130 | W 11-7 | 65-65 | 3 | 21,319 | Buddy Black | Richard Dotson | Buddy Black | Richard Dotson | | 565 | 560 | 5 |
| 1987-08-31 | @ CHA | 131 | L 3-5 | 65-66 | 4 | 9,166 | Danny Jackson | Jose DeLeon | Jose DeLeon | Danny Jackson | Bobby Thigpen | 568 | 565 | 3 |
| 1987-09-01 | vs MIL | 132 | L 0-2 | 65-67 | 4 | 19,067 | Bret Saberhagen | Teddy Higuera | Teddy Higuera | Bret Saberhagen | | 568 | 567 | 1 |
| 1987-09-02 | vs MIL | 133 | L 2-3 | 65-68 | 4 | 19,430 | Charlie Leibrandt | Bill Wegman | Bill Wegman | Charlie Leibrandt | Dan Plesac | 570 | 570 | 0 |
| 1987-09-03 | vs MIL | 134 | L 2-8 | 65-69 | 4 | 23,122 | Mark Gubicza | Chris Bosio | Chris Bosio | Mark Gubicza | Chuck Crim | 572 | 578 | -6 |
| 1987-09-04 | vs CHA | 135 | W 6-2 | 66-69 | 3 | 23,810 | Melido Perez | Richard Dotson | Melido Perez | Richard Dotson | | 578 | 580 | -2 |
| 1987-09-05 | vs CHA | 136 | W 4-2 | 67-69 | 3 | 34,391 | Danny Jackson | Jose DeLeon | Danny Jackson | Jose DeLeon | | 582 | 582 | 0 |
| 1987-09-06 | vs CHA | 137 | L 4-5 | 67-70 | 3 | 30,360 | Bret Saberhagen | Bill Long | Bobby Thigpen | John Davis | | 586 | 587 | -1 |
| 1987-09-07 | @ CAL | 138 | W 5-2 | 68-70 | 3 | 28,034 | Charlie Leibrandt | Mike Witt | Charlie Leibrandt | Mike Witt | Gene Garber | 591 | 589 | 2 |
| 1987-09-08 | @ CAL | 139 | W 4-2 | 69-70 | 3 | 25,637 | Mark Gubicza | Jerry Reuss | Mark Gubicza | Willie Fraser | John Davis | 595 | 591 | 4 |
| 1987-09-10 | @ OAK | 140 | L 2-3 | 69-71 | 3 | 12,361 | Danny Jackson | Curt Young | Eric Plunk | John Davis | | 597 | 594 | 3 |
| 1987-09-11 | @ OAK | 141 | W 9-0 | 70-71 | 3 | 22,296 | Bret Saberhagen | Steve Ontiveros | Bret Saberhagen | Steve Ontiveros | | 606 | 594 | 12 |
| 1987-09-12 | @ OAK | 142 | W 10-7 | 71-71 | 3 | 38,095 | Charlie Leibrandt | Dave Stewart | Charlie Leibrandt | Dave Stewart | Gene Garber | 616 | 601 | 15 |
| 1987-09-13 | @ OAK | 143 | W 6-5 | 72-71 | 2 | 27,683 | Mark Gubicza | Rick Honeycutt | Mark Gubicza | Rick Honeycutt | Gene Garber | 622 | 606 | 16 |
| 1987-09-14 | vs CAL | 144 | W 8-5 | 73-71 | 2 | 22,451 | Melido Perez | Don Sutton | Buddy Black | Jack Lazorko | Gene Garber | 630 | 611 | 19 |
| 1987-09-15 | vs CAL | 145 | L 1-7 | 73-72 | 2 | 17,682 | Danny Jackson | Willie Fraser | Willie Fraser | Danny Jackson | | 631 | 618 | 13 |
| 1987-09-16 | vs CAL | 146 | L 4-6 | 73-73 | 2 | 18,739 | Bret Saberhagen | Chuck Finley | Greg Minton | Bret Saberhagen | DeWayne Buice | 635 | 624 | 11 |
| 1987-09-17 | vs CAL | 147 | W 7-6 | 74-73 | 2 | 26,014 | Charlie Leibrandt | Mike Witt | John Davis | Greg Minton | | 642 | 630 | 12 |
| 1987-09-18 | vs OAK | 148 | L 0-4 | 74-74 | 3 | 31,301 | Mark Gubicza | Steve Ontiveros | Steve Ontiveros | Mark Gubicza | Dennis Eckersley | 642 | 634 | 8 |
| 1987-09-19 | vs OAK | 149 | L 5-9 | 74-75 | 3 | 38,685 | Melido Perez | Storm Davis | Storm Davis | Melido Perez | | 647 | 643 | 4 |
| 1987-09-20 | vs OAK | 150 | L 6-7 | 74-76 | 3 | 26,461 | Danny Jackson | Curt Young | Curt Young | Danny Jackson | Dennis Eckersley | 653 | 650 | 3 |
| 1987-09-21 | @ SEA | 151 | L 1-5 | 74-77 | 3 | 6,416 | Bret Saberhagen | Mike Campbell | Mike Campbell | Bret Saberhagen | | 654 | 655 | -1 |
| 1987-09-22 | @ SEA | 152 | W 4-3 | 75-77 | 3 | 7,706 | Charlie Leibrandt | Scott Bankhead | Jerry Gleaton | Jerry Reed | Gene Garber | 658 | 658 | 0 |
| 1987-09-23 | @ SEA | 153 | W 9-0 | 76-77 | 3 | 8,503 | Mark Gubicza | Mark Langston | Mark Gubicza | Mark Langston | | 667 | 658 | 9 |
| 1987-09-25 | @ MIN | 154 | W 6-4 | 77-77 | 2 | 52,704 | Danny Jackson | Les Straker | Steve Farr | Dan Schatzeder | Gene Garber | 673 | 662 | 11 |
| 1987-09-26 | @ MIN | 155 | W 7-4 | 78-77 | 2 | 46,263 | Bret Saberhagen | Steve Carlton | John Davis | Jeff Reardon | Gene Garber | 680 | 666 | 14 |
| 1987-09-27 | @ MIN | 156 | L 1-8 | 78-78 | 2 | 53,106 | Charlie Leibrandt | Bert Blyleven | Bert Blyleven | Charlie Leibrandt | | 681 | 674 | 7 |
| 1987-09-28 | vs SEA | 157 | L 1-5 | 78-79 | 2 | 22,068 | Mark Gubicza | Lee Guetterman | Lee Guetterman | Mark Gubicza | Jerry Reed | 682 | 679 | 3 |
| 1987-09-29 | vs SEA | 158 | W 6-3 | 79-79 | 2 | 17,458 | Buddy Black | Mark Langston | Buddy Black | Mark Langston | | 688 | 682 | 6 |
| 1987-09-30 | vs SEA | 159 | W 7-3 | 80-79 | 2 | 16,162 | Danny Jackson | Mike Morgan | Danny Jackson | Mike Morgan | | 695 | 685 | 10 |
| 1987-10-02 | vs MIN | 160 | W 6-3 | 81-79 | 2 | 22,578 | Bret Saberhagen | Frank Viola | Bret Saberhagen | Frank Viola | | 701 | 688 | 13 |
| 1987-10-03 | vs MIN | 161 | W 4-2 | 82-79 | 2 | 28,082 | Charlie Leibrandt | Bert Blyleven | Charlie Leibrandt | Bert Blyleven | Gene Garber | 705 | 690 | 15 |
| 1987-10-04 | vs MIN | 162 | W 10-1 | 83-79 | 2 | 26,341 | Mark Gubicza | Joe Niekro | Mark Gubicza | Joe Niekro | | 715 | 691 | 24 |