| 1986-04-08 | @ OAK | 1 | W 3-2 | 1-0 | 1 | 44,726 | Frank Viola | Chris Codiroli | Frank Viola | Chris Codiroli | Ron Davis | 3 | 2 | 1 |
| 1986-04-09 | @ OAK | 2 | W 5-4 | 2-0 | 1 | 12,213 | Mike Smithson | Jose Rijo | Mike Smithson | Jay Howell | | 8 | 6 | 2 |
| 1986-04-10 | @ OAK | 3 | L 0-3 | 2-1 | 1 | 11,287 | John Butcher | Moose Haas | Moose Haas | John Butcher | Jay Howell | 8 | 9 | -1 |
| 1986-04-11 | vs SEA | 4 | W 5-1 | 3-1 | 1 | 42,871 | Bert Blyleven | Milt Wilcox | Bert Blyleven | Milt Wilcox | Ron Davis | 13 | 10 | 3 |
| 1986-04-12 | vs SEA | 5 | L 4-10 | 3-2 | 1 | 14,708 | Frank Viola | Mike Morgan | Mike Morgan | Frank Viola | | 17 | 20 | -3 |
| 1986-04-13 | vs SEA | 6 | L 2-4 | 3-3 | 3 | 11,222 | Mike Smithson | Mike Moore | Mike Moore | Mike Smithson | | 19 | 24 | -5 |
| 1986-04-14 | vs OAK | 7 | L 6-7 | 3-4 | 5 | 8,240 | John Butcher | Jose Rijo | Keith Atherton | Roy Smith | Jay Howell | 25 | 31 | -6 |
| 1986-04-15 | vs OAK | 8 | L 2-8 | 3-5 | 6 | 8,097 | Bill Latham | Moose Haas | Moose Haas | Bill Latham | | 27 | 39 | -12 |
| 1986-04-16 | vs OAK | 9 | W 7-5 | 4-5 | 5 | 11,282 | Bert Blyleven | Joaquin Andujar | Ron Davis | Keith Atherton | | 34 | 44 | -10 |
| 1986-04-17 | @ CAL | 10 | W 4-1 | 5-5 | 4 | 22,787 | Frank Viola | Kirk McCaskill | Frank Viola | Kirk McCaskill | | 38 | 45 | -7 |
| 1986-04-18 | @ CAL | 11 | L 5-6 | 5-6 | 6 | 30,535 | Mike Smithson | Mike Witt | Mike Witt | Mike Smithson | Donnie Moore | 43 | 51 | -8 |
| 1986-04-19 | @ CAL | 12 | L 4-5 | 5-7 | 6 | 23,498 | John Butcher | Jim Slaton | Jim Slaton | John Butcher | Donnie Moore | 47 | 56 | -9 |
| 1986-04-20 | @ CAL | 13 | L 5-8 | 5-8 | 6 | 58,066 | Bert Blyleven | Don Sutton | Terry Forster | Ron Davis | | 52 | 64 | -12 |
| 1986-04-21 | @ SEA | 14 | W 5-2 | 6-8 | 5 | 13,106 | Frank Viola | Milt Wilcox | Frank Viola | Milt Wilcox | | 57 | 66 | -9 |
| 1986-04-22 | @ SEA | 15 | W 7-1 | 7-8 | 5 | 7,044 | Mike Smithson | Mike Morgan | Mike Smithson | Mike Morgan | | 64 | 67 | -3 |
| 1986-04-23 | @ SEA | 16 | L 3-4 | 7-9 | 5 | 7,547 | John Butcher | Mike Moore | Karl Best | Mark Portugal | | 67 | 71 | -4 |
| 1986-04-25 | vs CAL | 17 | W 7-4 | 8-9 | 5 | 16,156 | Bert Blyleven | Jim Slaton | Bert Blyleven | Jim Slaton | | 74 | 75 | -1 |
| 1986-04-26 | vs CAL | 18 | L 6-7 | 8-10 | 5 | 31,966 | Frank Viola | Don Sutton | T.R. Bryden | Ron Davis | Donnie Moore | 80 | 82 | -2 |
| 1986-04-27 | vs CAL | 19 | L 7-8 | 8-11 | 5 | 15,126 | Mike Smithson | Ron Romanick | T.R. Bryden | Roy Smith | Donnie Moore | 87 | 90 | -3 |
| 1986-04-29 | @ NYA | 20 | L 11-14 | 8-12 | 5 | 13,213 | John Butcher | Ron Guidry | Ed Whitson | Mark Portugal | | 98 | 104 | -6 |
| 1986-04-30 | @ NYA | 21 | L 2-3 | 8-13 | 5 | 18,774 | Bert Blyleven | Joe Niekro | Joe Niekro | Bert Blyleven | Brian Fisher | 100 | 107 | -7 |
| 1986-05-01 | @ NYA | 22 | W 7-4 | 9-13 | 5 | 15,081 | Frank Viola | Dennis Rasmussen | Juan Agosto | Dennis Rasmussen | | 107 | 111 | -4 |
| 1986-05-02 | @ DET | 23 | W 10-1 | 10-13 | 5 | 15,446 | Mike Smithson | Jack Morris | Mike Smithson | Jack Morris | | 117 | 112 | 5 |
| 1986-05-03 | @ DET | 24 | L 4-7 | 10-14 | 5 | 18,851 | John Butcher | Walt Terrell | Walt Terrell | John Butcher | | 121 | 119 | 2 |
| 1986-05-04 | @ DET | 25 | L 1-4 | 10-15 | 5 | 19,458 | Bert Blyleven | Frank Tanana | Frank Tanana | Bert Blyleven | Guillermo Hernandez | 122 | 123 | -1 |
| 1986-05-06 | vs BAL | 26 | L 3-5 | 10-16 | 5 | 11,836 | Frank Viola | Storm Davis | Storm Davis | Frank Viola | Don Aase | 125 | 128 | -3 |
| 1986-05-07 | vs BAL | 27 | W 5-2 | 11-16 | 5 | 9,257 | Mike Smithson | Mike Flanagan | Mike Smithson | Mike Flanagan | | 130 | 130 | 0 |
| 1986-05-09 | vs DET | 28 | W 8-7 | 12-16 | 5 | 16,477 | Bert Blyleven | Walt Terrell | Bert Blyleven | Randy O'Neal | Juan Agosto | 138 | 137 | 1 |
| 1986-05-10 | vs DET | 29 | W 12-2 | 13-16 | 4 | 22,388 | Frank Viola | Frank Tanana | Frank Viola | Frank Tanana | | 150 | 139 | 11 |
| 1986-05-11 | vs DET | 30 | L 1-4 | 13-17 | 4 | 22,189 | Mike Smithson | Dan Petry | Dan Petry | Mike Smithson | | 151 | 143 | 8 |
| 1986-05-12 | vs NYA | 31 | L 8-9 | 13-18 | 5 | 14,666 | Mark Portugal | Dennis Rasmussen | Dennis Rasmussen | Mark Portugal | Dave Righetti | 159 | 152 | 7 |
| 1986-05-13 | vs NYA | 32 | L 4-6 | 13-19 | 5 | 13,824 | Bert Blyleven | Tommy John | Tommy John | Bert Blyleven | Dave Righetti | 163 | 158 | 5 |
| 1986-05-14 | @ BAL | 33 | L 3-8 | 13-20 | 5 | 13,461 | John Butcher | Ken Dixon | Ken Dixon | Juan Agosto | | 166 | 166 | 0 |
| 1986-05-15 | @ BAL | 34 | L 3-5 | 13-21 | 5 | 15,277 | Frank Viola | Mike Boddicker | Mike Boddicker | Frank Viola | Don Aase | 169 | 171 | -2 |
| 1986-05-16 | @ MIL | 35 | L 6-7 | 13-22 | 7 | 11,077 | Mike Smithson | Bill Wegman | Mark Clear | Ron Davis | | 175 | 178 | -3 |
| 1986-05-17 | @ MIL | 36 | L 1-4 | 13-23 | 7 | 16,301 | Mark Portugal | Teddy Higuera | Teddy Higuera | Mark Portugal | | 176 | 182 | -6 |
| 1986-05-18 | @ MIL | 37 | W 5-3 | 14-23 | 6 | 30,062 | Bert Blyleven | Tim Leary | Bert Blyleven | Tim Leary | | 181 | 185 | -4 |
| 1986-05-19 | @ BOS | 38 | L 7-8 | 14-24 | 6 | 18,428 | John Butcher | Mike Brown | Joe Sambito | Ron Davis | | 188 | 193 | -5 |
| 1986-05-20 | @ BOS | 39 | L 7-17 | 14-25 | 6 | 20,880 | Frank Viola | Roger Clemens | Roger Clemens | Frank Viola | | 195 | 210 | -15 |
| 1986-05-21 | @ BOS | 40 | L 2-3 | 14-26 | 6 | 16,018 | Mike Smithson | Bruce Hurst | Sammy Stewart | Mark Portugal | Bob Stanley | 197 | 213 | -16 |
| 1986-05-23 | vs MIL | 41 | W 8-7 | 15-26 | 6 | 15,065 | Bert Blyleven | Tim Leary | Frank Pastore | Dan Plesac | | 205 | 220 | -15 |
| 1986-05-24 | vs MIL | 42 | L 3-6 | 15-27 | 6 | 20,991 | Frank Viola | Juan Nieves | Juan Nieves | Frank Viola | | 208 | 226 | -18 |
| 1986-05-25 | vs MIL | 43 | W 4-3 | 16-27 | 6 | 24,697 | Mike Smithson | Bill Wegman | Mike Smithson | Bill Wegman | | 212 | 229 | -17 |
| 1986-05-26 | vs TOR | 44 | W 9-1 | 17-27 | 6 | 10,885 | Mark Portugal | Doyle Alexander | Mark Portugal | Doyle Alexander | | 221 | 230 | -9 |
| 1986-05-27 | vs TOR | 45 | W 7-6 | 18-27 | 6 | 9,052 | John Butcher | Jimmy Key | Frank Pastore | Tom Henke | | 228 | 236 | -8 |
| 1986-05-28 | vs TOR | 46 | L 8-14 | 18-28 | 6 | 9,133 | Bert Blyleven | Jim Clancy | Jim Clancy | Bert Blyleven | | 236 | 250 | -14 |
| 1986-05-30 | vs BOS | 47 | W 13-5 | 19-28 | 5 | 16,669 | Frank Viola | Rob Woodward | Keith Atherton | Rob Woodward | | 249 | 255 | -6 |
| 1986-05-31 | vs BOS | 48 | L 2-7 | 19-29 | 5 | 20,217 | Mike Smithson | Bruce Hurst | Bruce Hurst | Mike Smithson | | 251 | 262 | -11 |
| 1986-06-01 | vs BOS | 49 | L 3-6 | 19-30 | 6 | 16,645 | Mark Portugal | Roger Clemens | Roger Clemens | Mark Portugal | | 254 | 268 | -14 |
| 1986-06-02 | @ TOR | 50 | L 1-3 | 19-31 | 6 | 26,022 | Bert Blyleven | Jim Clancy | Jim Clancy | Bert Blyleven | Tom Henke | 255 | 271 | -16 |
| 1986-06-03 | @ TOR | 51 | L 5-6 | 19-32 | 6 | 27,112 | John Butcher | John Cerutti | Mark Eichhorn | Keith Atherton | Tom Henke | 260 | 277 | -17 |
| 1986-06-04 | @ TOR | 52 | W 10-4 | 20-32 | 5 | 30,234 | Frank Viola | Dave Stieb | Frank Viola | Dave Stieb | | 270 | 281 | -11 |
| 1986-06-05 | @ KCA | 53 | L 2-8 | 20-33 | 6 | 30,343 | Mike Smithson | Mark Gubicza | Scott Bankhead | Mike Smithson | | 272 | 289 | -17 |
| 1986-06-06 | @ KCA | 54 | L 1-6 | 20-34 | 6 | 32,516 | Juan Agosto | Charlie Leibrandt | Charlie Leibrandt | Juan Agosto | | 273 | 295 | -22 |
| 1986-06-07 | @ KCA | 55 | W 4-1 | 21-34 | 6 | 37,204 | Bert Blyleven | Danny Jackson | Bert Blyleven | Danny Jackson | | 277 | 296 | -19 |
| 1986-06-08 | @ KCA | 56 | W 5-2 | 22-34 | 6 | 25,870 | Mark Portugal | Bret Saberhagen | Mark Portugal | Bret Saberhagen | Frank Pastore | 282 | 298 | -16 |
| 1986-06-09 | vs TEX | 57 | W 3-2 | 23-34 | 6 | 10,782 | Frank Viola | Bobby Witt | Keith Atherton | Mitch Williams | | 285 | 300 | -15 |
| 1986-06-10 | vs TEX | 58 | L 10-14 | 23-35 | 6 | 12,084 | Mike Smithson | Mickey Mahler | Jeff Russell | Ron Davis | Greg Harris | 295 | 314 | -19 |
| 1986-06-11 | vs TEX | 59 | L 2-6 | 23-36 | 6 | 11,506 | Allan Anderson | Charlie Hough | Mitch Williams | Roy Lee Jackson | | 297 | 320 | -23 |
| 1986-06-13 | @ CLE | 60 | L 2-11 | 23-37 | 6 | 61,411 | Bert Blyleven | Tom Candiotti | Tom Candiotti | Bert Blyleven | | 299 | 331 | -32 |
| 1986-06-14 | @ CLE | 61 | W 9-3 | 24-37 | 6 | 10,742 | Mark Portugal | Neal Heaton | Keith Atherton | Neal Heaton | | 308 | 334 | -26 |
| 1986-06-15 | @ CLE | 62 | W 7-3 | 25-37 | 6 | 15,657 | Frank Viola | Don Schulze | Frank Viola | Don Schulze | Frank Pastore | 315 | 337 | -22 |
| 1986-06-17 | vs CHA | 63 | W 4-1 | 26-37 | 5 | 14,303 | Mike Smithson | Richard Dotson | Mike Smithson | Richard Dotson | Keith Atherton | 319 | 338 | -19 |
| 1986-06-18 | vs CHA | 64 | W 10-9 | 27-37 | 5 | 13,123 | Bert Blyleven | Joe Cowley | Ron Davis | Gene Nelson | | 329 | 347 | -18 |
| 1986-06-19 | vs CHA | 65 | L 8-9 | 27-38 | 5 | 17,432 | Allan Anderson | Joel Davis | Floyd Bannister | Allan Anderson | Bob James | 337 | 356 | -19 |
| 1986-06-20 | vs CLE | 66 | W 9-8 | 28-38 | 4 | 13,403 | Frank Viola | Bryan Oelkers | Frank Viola | Dickie Noles | Keith Atherton | 346 | 364 | -18 |
| 1986-06-21 | vs CLE | 67 | L 5-7 | 28-39 | 4 | 17,195 | Mark Portugal | Don Schulze | Don Schulze | Mark Portugal | Ernie Camacho | 351 | 371 | -20 |
| 1986-06-22 | vs CLE | 68 | L 1-4 | 28-40 | 5 | 12,435 | Mike Smithson | Phil Niekro | Phil Niekro | Mike Smithson | | 352 | 375 | -23 |
| 1986-06-23 | @ CHA | 69 | L 2-11 | 28-41 | 5 | 18,687 | Bert Blyleven | Joe Cowley | Joe Cowley | Bert Blyleven | | 354 | 386 | -32 |
| 1986-06-24 | @ CHA | 70 | W 2-1 | 29-41 | 5 | 14,174 | Allan Anderson | Joel Davis | Allan Anderson | Joel Davis | | 356 | 387 | -31 |
| 1986-06-25 | @ CHA | 71 | L 3-4 | 29-42 | 5 | 19,294 | Frank Viola | Tom Seaver | Joel McKeon | Frank Viola | Bob James | 359 | 391 | -32 |
| 1986-06-27 | vs KCA | 72 | W 6-4 | 30-42 | 5 | 22,439 | Mike Smithson | Scott Bankhead | Mike Smithson | Scott Bankhead | Keith Atherton | 365 | 395 | -30 |
| 1986-06-28 | vs KCA | 73 | W 7-2 | 31-42 | 5 | 31,789 | Bert Blyleven | Danny Jackson | Bert Blyleven | Danny Jackson | Neal Heaton | 372 | 397 | -25 |
| 1986-06-29 | vs KCA | 74 | W 9-4 | 32-42 | 5 | 22,727 | Allan Anderson | Bret Saberhagen | Allan Anderson | Bret Saberhagen | Keith Atherton | 381 | 401 | -20 |
| 1986-06-30 | @ TEX | 75 | W 5-2 | 33-42 | 5 | 16,997 | Frank Viola | Bobby Witt | Frank Viola | Greg Harris | Keith Atherton | 386 | 403 | -17 |
| 1986-07-01 | @ TEX | 76 | L 0-5 | 33-43 | 5 | 29,632 | Mark Portugal | Charlie Hough | Charlie Hough | Mark Portugal | | 386 | 408 | -22 |
| 1986-07-02 | @ TEX | 77 | L 2-10 | 33-44 | 5 | 14,740 | Mike Smithson | Mike Mason | Mike Mason | Mike Smithson | | 388 | 418 | -30 |
| 1986-07-03 | vs BAL | 78 | W 11-7 | 34-44 | 5 | 14,057 | Bert Blyleven | Mike Boddicker | Bert Blyleven | Mike Boddicker | | 399 | 425 | -26 |
| 1986-07-04 | vs BAL | 79 | L 7-12 | 34-45 | 5 | 13,683 | Allan Anderson | Scott McGregor | Brad Havens | Frank Pastore | Don Aase | 406 | 437 | -31 |
| 1986-07-05 | vs BAL | 80 | W 7-6 | 35-45 | 5 | 14,716 | Frank Viola | Mike Flanagan | Frank Viola | Mike Flanagan | | 413 | 443 | -30 |
| 1986-07-06 | vs BAL | 81 | L 0-1 | 35-46 | 5 | 12,707 | Neal Heaton | Ken Dixon | Ken Dixon | Neal Heaton | Don Aase | 413 | 444 | -31 |
| 1986-07-07 | vs DET | 82 | W 10-8 | 36-46 | 5 | 12,689 | Mike Smithson | Randy O'Neal | Mike Smithson | Randy O'Neal | Keith Atherton | 423 | 452 | -29 |
| 1986-07-08 | vs DET | 83 | L 1-5 | 36-47 | 5 | 16,320 | Bert Blyleven | Eric King | Eric King | Bert Blyleven | Guillermo Hernandez | 424 | 457 | -33 |
| 1986-07-09 | vs DET | 84 | L 0-7 | 36-48 | 5 | 21,489 | Allan Anderson | Jack Morris | Jack Morris | Allan Anderson | | 424 | 464 | -40 |
| 1986-07-10 | vs NYA | 85 | L 1-11 | 36-49 | 6 | 21,759 | Frank Viola | Dennis Rasmussen | Dennis Rasmussen | Frank Viola | | 425 | 475 | -50 |
| 1986-07-11 | vs NYA | 86 | L 3-9 | 36-50 | 6 | 25,020 | Neal Heaton | Doug Drabek | Doug Drabek | Neal Heaton | Brian Fisher | 428 | 484 | -56 |
| 1986-07-12 | vs NYA | 87 | L 0-8 | 36-51 | 6 | 30,366 | Mike Smithson | Scott Nielsen | Scott Nielsen | Mike Smithson | | 428 | 492 | -64 |
| 1986-07-13 | vs NYA | 88 | W 5-0 | 37-51 | 6 | 26,722 | Bert Blyleven | Bob Tewksbury | Bert Blyleven | Bob Tewksbury | | 433 | 492 | -59 |
| 1986-07-17 | @ BAL | 89 | L 2-6 | 37-52 | 6 | 20,317 | Frank Viola | Ken Dixon | Ken Dixon | Frank Viola | Don Aase | 435 | 498 | -63 |
| 1986-07-18 | @ BAL | 90 | W 7-3 | 38-52 | 6 | 33,914 | Bert Blyleven | Scott McGregor | Bert Blyleven | Scott McGregor | Keith Atherton | 442 | 501 | -59 |
| 1986-07-19 | @ BAL | 91 | L 0-1 | 38-53 | 6 | 30,556 | Neal Heaton | Mike Flanagan | Mike Flanagan | Neal Heaton | Don Aase | 442 | 502 | -60 |
| 1986-07-20 | @ BAL | 92 | L 3-8 | 38-54 | 6 | 25,045 | Mike Smithson | Mike Boddicker | Mike Boddicker | Mike Smithson | | 445 | 510 | -65 |
| 1986-07-21 | @ DET | 93 | W 1-0 | 39-54 | 6 | 21,895 | Frank Viola | Mark Thurmond | Frank Viola | Mark Thurmond | Keith Atherton | 446 | 510 | -64 |
| 1986-07-22 | @ DET | 94 | L 0-3 | 39-55 | 6 | 18,974 | Bert Blyleven | Walt Terrell | Walt Terrell | Bert Blyleven | Guillermo Hernandez | 446 | 513 | -67 |
| 1986-07-23 | @ DET | 95 | L 2-12 | 39-56 | 7 | 23,096 | Allan Anderson | Jack Morris | Jack Morris | Allan Anderson | | 448 | 525 | -77 |
| 1986-07-25 | @ NYA | 96 | W 9-5 | 40-56 | 7 | 32,201 | Neal Heaton | Scott Nielsen | Neal Heaton | Scott Nielsen | Keith Atherton | 457 | 530 | -73 |
| 1986-07-26 | @ NYA | 97 | W 8-4 | 41-56 | 7 | 36,335 | Frank Viola | Doug Drabek | Allan Anderson | Doug Drabek | | 465 | 534 | -69 |
| 1986-07-27 | @ NYA | 98 | L 1-4 | 41-57 | 7 | 30,312 | Bert Blyleven | Ron Guidry | Ron Guidry | Bert Blyleven | Dave Righetti | 466 | 538 | -72 |
| 1986-07-28 | vs SEA | 99 | W 6-5 | 42-57 | 7 | 14,879 | Mike Smithson | Mike Moore | Keith Atherton | Karl Best | | 472 | 543 | -71 |
| 1986-07-29 | vs SEA | 100 | W 4-2 | 43-57 | 7 | 10,991 | Frank Viola | Jim Beattie | Frank Viola | Jim Beattie | Roy Lee Jackson | 476 | 545 | -69 |
| 1986-07-30 | vs SEA | 101 | L 2-4 | 43-58 | 7 | 10,396 | Neal Heaton | Mike Morgan | Mike Morgan | Neal Heaton | Matt Young | 478 | 549 | -71 |
| 1986-08-01 | vs OAK | 102 | W 10-1 | 44-58 | 6 | 14,855 | Bert Blyleven | Curt Young | Bert Blyleven | Curt Young | | 488 | 550 | -62 |
| 1986-08-02 | vs OAK | 103 | W 8-0 | 45-58 | 6 | 29,311 | Mike Smithson | Joaquin Andujar | Mike Smithson | Joaquin Andujar | | 496 | 550 | -54 |
| 1986-08-03 | vs OAK | 104 | L 4-5 | 45-59 | 6 | 16,521 | Frank Viola | Dave Stewart | Doug Bair | Keith Atherton | Jay Howell | 500 | 555 | -55 |
| 1986-08-04 | vs CAL | 105 | W 6-5 | 46-59 | 6 | 14,986 | Neal Heaton | John Candelaria | Frank Pastore | Donnie Moore | | 506 | 560 | -54 |
| 1986-08-05 | vs CAL | 106 | L 1-13 | 46-60 | 6 | 22,689 | Allan Anderson | Mike Witt | Mike Witt | Allan Anderson | | 507 | 573 | -66 |
| 1986-08-06 | vs CAL | 107 | W 5-2 | 47-60 | 6 | 21,129 | Bert Blyleven | Don Sutton | Bert Blyleven | Don Sutton | | 512 | 575 | -63 |
| 1986-08-08 | @ OAK | 108 | L 2-5 | 47-61 | 5 | 11,746 | Mike Smithson | Joaquin Andujar | Joaquin Andujar | Mike Smithson | Doug Bair | 514 | 580 | -66 |
| 1986-08-09 | @ OAK | 109 | W 9-2 | 48-61 | 4 | 18,886 | Frank Viola | Dave Stewart | Frank Viola | Dave Stewart | | 523 | 582 | -59 |
| 1986-08-10 | @ OAK | 110 | L 2-6 | 48-63 | 6 | 0 | Neal Heaton | Curt Young | Curt Young | Neal Heaton | Jay Howell | 525 | 588 | -63 |
| 1986-08-10 | @ OAK | 111 | L 5-6 | 48-63 | 6 | 13,455 | Frank Pastore | Jose Rijo | Jose Rijo | Keith Atherton | Jay Howell | 530 | 594 | -64 |
| 1986-08-11 | @ CAL | 112 | W 2-0 | 49-63 | 5 | 25,802 | Bert Blyleven | Don Sutton | Bert Blyleven | Don Sutton | | 532 | 594 | -62 |
| 1986-08-12 | @ CAL | 113 | L 4-5 | 49-64 | 6 | 29,094 | Mike Smithson | Kirk McCaskill | Gary Lucas | Ron Davis | | 536 | 599 | -63 |
| 1986-08-13 | @ CAL | 114 | W 6-2 | 50-64 | 6 | 27,533 | Frank Viola | Vern Ruhle | Frank Viola | Vern Ruhle | | 542 | 601 | -59 |
| 1986-08-14 | @ SEA | 115 | W 14-1 | 51-64 | 6 | 8,743 | Mark Portugal | Mark Langston | Mark Portugal | Mark Langston | | 556 | 602 | -46 |
| 1986-08-15 | @ SEA | 116 | L 0-1 | 51-65 | 6 | 7,726 | Neal Heaton | Mike Moore | Mike Moore | Keith Atherton | | 556 | 603 | -47 |
| 1986-08-16 | @ SEA | 117 | L 6-7 | 51-66 | 6 | 15,535 | Bert Blyleven | Bill Swift | Pete Ladd | Keith Atherton | | 562 | 610 | -48 |
| 1986-08-17 | @ SEA | 118 | L 1-11 | 51-67 | 7 | 8,253 | Mike Smithson | Mike Morgan | Mike Morgan | Mike Smithson | | 563 | 621 | -58 |
| 1986-08-18 | vs BOS | 119 | L 1-3 | 51-68 | 7 | 20,492 | Frank Viola | Tom Seaver | Tom Seaver | Frank Viola | Bob Stanley | 564 | 624 | -60 |
| 1986-08-19 | vs BOS | 120 | W 5-1 | 52-68 | 7 | 13,698 | Mark Portugal | Al Nipper | Mark Portugal | Al Nipper | George Frazier | 569 | 625 | -56 |
| 1986-08-20 | vs BOS | 121 | L 1-9 | 52-69 | 7 | 23,485 | Neal Heaton | Roger Clemens | Roger Clemens | Neal Heaton | | 570 | 634 | -64 |
| 1986-08-22 | vs TOR | 122 | W 4-3 | 53-69 | 5 | 14,359 | Bert Blyleven | Jim Clancy | Bert Blyleven | Jim Clancy | George Frazier | 574 | 637 | -63 |
| 1986-08-23 | vs TOR | 123 | L 4-7 | 53-70 | 6 | 22,604 | Mike Smithson | John Cerutti | John Cerutti | Mike Smithson | Mark Eichhorn | 578 | 644 | -66 |
| 1986-08-24 | vs TOR | 124 | L 5-7 | 53-71 | 7 | 18,117 | Frank Viola | Dave Stieb | Tom Henke | Keith Atherton | | 583 | 651 | -68 |
| 1986-08-26 | @ MIL | 125 | L 5-6 | 53-72 | 7 | 10,048 | Mark Portugal | Bill Wegman | Mark Clear | Keith Atherton | | 588 | 657 | -69 |
| 1986-08-27 | @ MIL | 126 | W 7-5 | 54-72 | 7 | 9,161 | Neal Heaton | Juan Nieves | Neal Heaton | Juan Nieves | George Frazier | 595 | 662 | -67 |
| 1986-08-28 | @ MIL | 127 | W 6-2 | 55-72 | 7 | 13,854 | Bert Blyleven | Chris Bosio | Bert Blyleven | Chris Bosio | | 601 | 664 | -63 |
| 1986-08-29 | @ TOR | 128 | L 5-6 | 55-73 | 7 | 38,241 | Mike Smithson | Dave Stieb | Mark Eichhorn | Keith Atherton | | 606 | 670 | -64 |
| 1986-08-30 | @ TOR | 129 | L 1-8 | 55-74 | 7 | 43,556 | Frank Viola | Joe Johnson | Joe Johnson | Frank Viola | Dennis Lamp | 607 | 678 | -71 |
| 1986-08-31 | @ TOR | 130 | L 5-7 | 55-75 | 7 | 45,161 | Mark Portugal | John Cerutti | Luis Aquino | Allan Anderson | Mark Eichhorn | 612 | 685 | -73 |
| 1986-09-01 | vs MIL | 131 | W 9-3 | 56-75 | 7 | 16,374 | Neal Heaton | Juan Nieves | Neal Heaton | Juan Nieves | George Frazier | 621 | 688 | -67 |
| 1986-09-02 | vs MIL | 132 | W 4-0 | 57-75 | 7 | 8,616 | Bert Blyleven | Pete Vuckovich | Bert Blyleven | Pete Vuckovich | | 625 | 688 | -63 |
| 1986-09-03 | vs MIL | 133 | W 11-5 | 58-75 | 7 | 9,391 | Mike Smithson | Teddy Higuera | Mike Smithson | Teddy Higuera | | 636 | 693 | -57 |
| 1986-09-05 | @ BOS | 134 | L 2-12 | 58-76 | 7 | 30,546 | Frank Viola | Roger Clemens | Roger Clemens | Frank Viola | | 638 | 705 | -67 |
| 1986-09-06 | @ BOS | 135 | L 2-3 | 58-77 | 7 | 31,236 | Mark Portugal | Oil Can Boyd | Oil Can Boyd | George Frazier | | 640 | 708 | -68 |
| 1986-09-07 | @ BOS | 136 | L 0-9 | 58-78 | 7 | 30,359 | Neal Heaton | Bruce Hurst | Bruce Hurst | Neal Heaton | | 640 | 717 | -77 |
| 1986-09-08 | @ KCA | 137 | L 0-5 | 58-79 | 7 | 21,425 | Bert Blyleven | Dennis Leonard | Dennis Leonard | Bert Blyleven | | 640 | 722 | -82 |
| 1986-09-09 | @ KCA | 138 | L 3-11 | 58-80 | 7 | 17,300 | Mike Smithson | Mark Gubicza | Mark Gubicza | Mike Smithson | Steve Farr | 643 | 733 | -90 |
| 1986-09-11 | vs TEX | 139 | W 6-2 | 59-80 | 7 | 6,875 | Frank Viola | Charlie Hough | Frank Viola | Charlie Hough | | 649 | 735 | -86 |
| 1986-09-12 | vs TEX | 140 | W 4-2 | 60-80 | 7 | 9,236 | Neal Heaton | Ed Correa | Neal Heaton | Ed Correa | Keith Atherton | 653 | 737 | -84 |
| 1986-09-13 | vs TEX | 141 | L 1-14 | 60-81 | 7 | 10,820 | Bert Blyleven | Mike Mason | Mike Mason | Bert Blyleven | | 654 | 751 | -97 |
| 1986-09-14 | vs TEX | 142 | W 7-6 | 61-81 | 7 | 9,571 | Mark Portugal | Jose Guzman | George Frazier | Dale Mohorcic | | 661 | 757 | -96 |
| 1986-09-15 | @ CLE | 143 | L 0-4 | 61-82 | 7 | 4,055 | Frank Viola | Tom Candiotti | Tom Candiotti | Frank Viola | | 661 | 761 | -100 |
| 1986-09-16 | @ CLE | 144 | W 7-3 | 62-82 | 7 | 4,940 | Bill Latham | Scott Bailes | Mark Portugal | Scott Bailes | | 668 | 764 | -96 |
| 1986-09-17 | @ CLE | 145 | L 2-5 | 62-83 | 7 | 5,101 | Neal Heaton | Greg Swindell | Greg Swindell | Mike Smithson | Frank Wills | 670 | 769 | -99 |
| 1986-09-19 | @ TEX | 146 | L 1-4 | 62-84 | 7 | 15,315 | Bert Blyleven | Charlie Hough | Charlie Hough | Bert Blyleven | | 671 | 773 | -102 |
| 1986-09-20 | @ TEX | 147 | W 3-2 | 63-84 | 7 | 27,118 | Frank Viola | Mike Mason | Frank Viola | Mitch Williams | George Frazier | 674 | 775 | -101 |
| 1986-09-21 | @ TEX | 148 | L 1-2 | 63-85 | 7 | 10,838 | Mark Portugal | Bobby Witt | Bobby Witt | Mark Portugal | Greg Harris | 675 | 777 | -102 |
| 1986-09-22 | vs KCA | 149 | W 2-1 | 64-85 | 7 | 7,488 | Neal Heaton | Danny Jackson | Keith Atherton | Danny Jackson | | 677 | 778 | -101 |
| 1986-09-23 | vs KCA | 150 | W 9-2 | 65-85 | 7 | 7,714 | Mike Smithson | Dennis Leonard | Mike Smithson | Dennis Leonard | | 686 | 780 | -94 |
| 1986-09-24 | vs KCA | 151 | L 1-2 | 65-86 | 7 | 6,835 | Bert Blyleven | Mark Gubicza | Dan Quisenberry | Bert Blyleven | | 687 | 782 | -95 |
| 1986-09-25 | vs KCA | 152 | L 1-8 | 65-87 | 7 | 7,694 | Frank Viola | Bret Saberhagen | Bret Saberhagen | Frank Viola | Dan Quisenberry | 688 | 790 | -102 |
| 1986-09-27 | @ CHA | 153 | L 2-5 | 65-89 | 7 | 0 | Neal Heaton | Jose DeLeon | Jose DeLeon | Neal Heaton | | 690 | 795 | -105 |
| 1986-09-27 | @ CHA | 154 | L 3-4 | 65-89 | 7 | 14,148 | Allan Anderson | Richard Dotson | Dave J. Schmidt | Mark Portugal | | 693 | 799 | -106 |
| 1986-09-28 | @ CHA | 155 | W 6-1 | 66-89 | 7 | 11,606 | Mike Smithson | Floyd Bannister | Mike Smithson | Floyd Bannister | George Frazier | 699 | 800 | -101 |
| 1986-09-29 | vs CLE | 156 | W 6-5 | 67-89 | 6 | 6,232 | Bert Blyleven | Greg Swindell | Bert Blyleven | Greg Swindell | Mark Portugal | 705 | 805 | -100 |
| 1986-09-30 | vs CLE | 157 | W 10-9 | 68-89 | 6 | 5,605 | Frank Viola | Phil Niekro | Mark Portugal | Ernie Camacho | | 715 | 814 | -99 |
| 1986-10-01 | vs CLE | 158 | L 3-12 | 68-90 | 6 | 5,112 | Allan Anderson | Tom Candiotti | Tom Candiotti | Allan Anderson | | 718 | 826 | -108 |
| 1986-10-02 | vs CHA | 159 | L 4-8 | 68-91 | 6 | 5,673 | Neal Heaton | Jose DeLeon | Bobby Thigpen | Neal Heaton | | 722 | 834 | -112 |
| 1986-10-03 | vs CHA | 160 | W 9-2 | 69-91 | 6 | 7,069 | Mike Smithson | Richard Dotson | Mike Smithson | Richard Dotson | | 731 | 836 | -105 |
| 1986-10-04 | vs CHA | 161 | W 7-3 | 70-91 | 6 | 28,136 | Bert Blyleven | Floyd Bannister | Bert Blyleven | Floyd Bannister | | 738 | 839 | -101 |
| 1986-10-05 | vs CHA | 162 | W 3-0 | 71-91 | 6 | 7,208 | Frank Viola | Joe Cowley | Frank Viola | Joe Cowley | | 741 | 839 | -98 |