| 1985-04-08 | vs MON | 1 | W 4-1 | 1-0 | 1 | 52,971 | Mario Soto | Steve Rogers | Mario Soto | Steve Rogers | Carl Willis | 4 | 1 | 3 |
| 1985-04-10 | vs MON | 2 | L 1-4 | 1-1 | 2 | 10,491 | Jay Tibbs | Bill Gullickson | Bill Gullickson | Jay Tibbs | | 5 | 5 | 0 |
| 1985-04-12 | @ NYN | 3 | L 0-1 | 1-2 | 6 | 31,120 | Mario Soto | Bruce Berenyi | Bruce Berenyi | Mario Soto | Doug Sisk | 5 | 6 | -1 |
| 1985-04-13 | @ NYN | 4 | L 1-2 | 1-3 | 6 | 26,212 | Tom Browning | Ed Lynch | Roger McDowell | John Franco | | 6 | 8 | -2 |
| 1985-04-14 | @ NYN | 5 | L 0-4 | 1-4 | 6 | 30,456 | Jay Tibbs | Dwight Gooden | Dwight Gooden | Jay Tibbs | | 6 | 12 | -6 |
| 1985-04-15 | @ ATL | 6 | W 9-8 | 2-4 | 6 | 7,404 | John Stuper | Pascual Perez | John Stuper | Pascual Perez | Ted Power | 15 | 20 | -5 |
| 1985-04-16 | @ ATL | 7 | W 2-1 | 3-4 | 5 | 15,175 | Mario Soto | Len Barker | Mario Soto | Rick Camp | | 17 | 21 | -4 |
| 1985-04-17 | @ ATL | 8 | W 6-1 | 4-4 | 4 | 13,513 | Tom Browning | Steve Bedrosian | Tom Browning | Steve Bedrosian | | 23 | 22 | 1 |
| 1985-04-18 | vs SFN | 9 | W 4-3 | 5-4 | 2 | 12,410 | Jay Tibbs | Mike Krukow | Carl Willis | Greg Minton | | 27 | 25 | 2 |
| 1985-04-19 | vs SFN | 10 | W 4-2 | 6-4 | 1 | 24,839 | John Stuper | Bill Laskey | John Stuper | Bill Laskey | Ted Power | 31 | 27 | 4 |
| 1985-04-20 | vs SFN | 11 | W 2-1 | 7-4 | 1 | 18,115 | Mario Soto | Jim Gott | Mario Soto | Frank Williams | | 33 | 28 | 5 |
| 1985-04-21 | vs SFN | 12 | W 1-0 | 8-4 | 1 | 29,418 | Tom Browning | Atlee Hammaker | Tom Browning | Atlee Hammaker | Ted Power | 34 | 28 | 6 |
| 1985-04-22 | @ HOU | 13 | L 1-4 | 8-5 | 1 | 10,197 | Jay Tibbs | Mike Scott | Mike Scott | Jay Tibbs | Dave Smith | 35 | 32 | 3 |
| 1985-04-23 | @ HOU | 14 | L 4-6 | 8-6 | 1 | 10,414 | John Stuper | Ron Mathis | Ron Mathis | John Stuper | Dave Smith | 39 | 38 | 1 |
| 1985-04-24 | @ HOU | 15 | W 8-3 | 9-6 | 1 | 8,513 | Mario Soto | Nolan Ryan | Mario Soto | Frank DiPino | | 47 | 41 | 6 |
| 1985-04-25 | @ SFN | 16 | L 3-7 | 9-7 | 2 | 4,056 | Frank Pastore | Jim Gott | Mark Davis | Tom Hume | | 50 | 48 | 2 |
| 1985-04-26 | @ SFN | 17 | L 6-7 | 9-8 | 2 | 12,534 | Jay Tibbs | Atlee Hammaker | Vida Blue | Ted Power | | 56 | 55 | 1 |
| 1985-04-27 | @ SFN | 18 | W 2-1 | 10-8 | 2 | 14,480 | John Stuper | Dave LaPoint | John Stuper | Dave LaPoint | | 58 | 56 | 2 |
| 1985-04-28 | @ SFN | 19 | L 1-2 | 10-9 | 3 | 32,963 | Mario Soto | Mike Krukow | Greg Minton | Tom Hume | | 59 | 58 | 1 |
| 1985-04-30 | vs ATL | 20 | L 4-8 | 10-10 | 3 | 14,356 | Jay Tibbs | Steve Bedrosian | Gene Garber | Jay Tibbs | | 63 | 66 | -3 |
| 1985-05-01 | vs ATL | 21 | L 9-17 | 10-11 | 5 | 6,412 | John Stuper | Rick Mahler | Rick Mahler | John Stuper | | 72 | 83 | -11 |
| 1985-05-03 | vs NYN | 22 | L 4-9 | 10-12 | 5 | 21,062 | Mario Soto | Ed Lynch | Ed Lynch | Mario Soto | | 76 | 92 | -16 |
| 1985-05-04 | vs NYN | 23 | W 14-2 | 11-12 | 3 | 16,634 | Jay Tibbs | Roger McDowell | Jay Tibbs | Roger McDowell | | 90 | 94 | -4 |
| 1985-05-05 | vs NYN | 24 | L 2-3 | 11-13 | 5 | 20,179 | Tom Browning | Dwight Gooden | Dwight Gooden | Tom Browning | Jesse Orosco | 92 | 97 | -5 |
| 1985-05-07 | @ PHI | 25 | W 2-0 | 12-13 | 4 | 21,902 | Mario Soto | Kevin Gross | Mario Soto | Kevin Gross | Ted Power | 94 | 97 | -3 |
| 1985-05-08 | @ PHI | 26 | W 8-2 | 13-13 | 3 | 22,416 | Jay Tibbs | John Denny | Jay Tibbs | John Denny | | 102 | 99 | 3 |
| 1985-05-10 | vs HOU | 27 | W 5-2 | 14-13 | 3 | 22,097 | Tom Browning | Joe Niekro | Tom Browning | Frank DiPino | Ted Power | 107 | 101 | 6 |
| 1985-05-11 | vs HOU | 28 | L 7-10 | 14-14 | 3 | 26,098 | Mario Soto | Mike Scott | Julio Solano | Mario Soto | Dave Smith | 114 | 111 | 3 |
| 1985-05-12 | vs HOU | 29 | L 5-10 | 14-15 | 4 | 15,749 | Jay Tibbs | Bob Knepper | Bob Knepper | Jay Tibbs | Jeff Calhoun | 119 | 121 | -2 |
| 1985-05-13 | vs PHI | 30 | W 7-3 | 15-15 | 4 | 12,068 | John Stuper | John Denny | John Stuper | John Denny | | 126 | 124 | 2 |
| 1985-05-14 | vs PHI | 31 | L 1-7 | 15-16 | 4 | 10,079 | Tom Browning | Charles Hudson | Charles Hudson | Tom Browning | | 127 | 131 | -4 |
| 1985-05-15 | @ MON | 32 | W 2-1 | 16-16 | 3 | 23,198 | Joe Price | Bryn Smith | Joe Price | Bryn Smith | Ted Power | 129 | 132 | -3 |
| 1985-05-16 | @ MON | 33 | W 4-2 | 17-16 | 3 | 18,128 | Jay Tibbs | Bill Gullickson | Jay Tibbs | Bill Gullickson | Tom Hume | 133 | 134 | -1 |
| 1985-05-17 | @ PIT | 34 | W 6-3 | 18-16 | 2 | 7,239 | John Stuper | Jose DeLeon | John Stuper | Jose DeLeon | Ted Power | 139 | 137 | 2 |
| 1985-05-18 | @ PIT | 35 | W 8-0 | 19-16 | 2 | 9,708 | Tom Browning | Mike Bielecki | Tom Browning | Mike Bielecki | | 147 | 137 | 10 |
| 1985-05-19 | @ PIT | 36 | W 7-1 | 20-16 | 2 | 11,990 | Mario Soto | Lee Tunnell | Mario Soto | Lee Tunnell | | 154 | 138 | 16 |
| 1985-05-20 | @ CHN | 37 | L 1-6 | 20-17 | 2 | 21,231 | Jay Tibbs | Scott Sanderson | Scott Sanderson | Jay Tibbs | | 155 | 144 | 11 |
| 1985-05-21 | @ CHN | 38 | W 5-2 | 21-17 | 2 | 32,007 | John Stuper | Ray Fontenot | Tom Hume | George Frazier | Ted Power | 160 | 146 | 14 |
| 1985-05-22 | @ CHN | 39 | L 4-7 | 21-18 | 2 | 27,863 | Tom Browning | Dennis Eckersley | Dennis Eckersley | Tom Browning | Lee Smith | 164 | 153 | 11 |
| 1985-05-24 | vs SLN | 40 | W 7-6 | 22-18 | 2 | 20,665 | Mario Soto | John Tudor | John Franco | Ricky Horton | | 171 | 159 | 12 |
| 1985-05-25 | vs SLN | 41 | L 4-6 | 22-19 | 2 | 24,846 | Jay Tibbs | Joaquin Andujar | Joaquin Andujar | Jay Tibbs | Ken Dayley | 175 | 165 | 10 |
| 1985-05-26 | vs SLN | 42 | L 2-7 | 22-20 | 2 | 21,349 | John Stuper | Danny Cox | Danny Cox | John Stuper | | 177 | 172 | 5 |
| 1985-05-27 | vs CHN | 43 | L 3-4 | 22-21 | 3 | 20,046 | Tom Browning | Dennis Eckersley | Dennis Eckersley | Tom Browning | Lee Smith | 180 | 176 | 4 |
| 1985-05-28 | vs CHN | 44 | W 13-11 | 23-21 | 2 | 15,121 | Jay Tibbs | Larry Gura | John Franco | Lary Sorensen | | 193 | 187 | 6 |
| 1985-05-29 | vs CHN | 45 | W 1-0 | 24-21 | 2 | 18,402 | Mario Soto | Dick Ruthven | Mario Soto | Dick Ruthven | | 194 | 187 | 7 |
| 1985-05-31 | @ SLN | 46 | L 0-5 | 24-22 | 2 | 38,910 | John Stuper | Danny Cox | Danny Cox | John Stuper | | 194 | 192 | 2 |
| 1985-06-01 | @ SLN | 47 | W 9-3 | 25-22 | 2 | 35,586 | Tom Browning | Kurt Kepshire | Tom Browning | Kurt Kepshire | Tom Hume | 203 | 195 | 8 |
| 1985-06-02 | @ SLN | 48 | W 8-3 | 26-22 | 2 | 33,774 | Jay Tibbs | Bob Forsch | Jay Tibbs | Bob Forsch | | 211 | 198 | 13 |
| 1985-06-04 | vs PIT | 49 | W 9-3 | 27-22 | 2 | 13,222 | Mario Soto | Jim Winn | Mario Soto | Cecilio Guante | | 220 | 201 | 19 |
| 1985-06-05 | vs PIT | 50 | W 11-9 | 28-22 | 2 | 12,540 | John Stuper | Rick Rhoden | Frank Pastore | Don Robinson | John Franco | 231 | 210 | 21 |
| 1985-06-07 | vs SDN | 51 | L 3-9 | 28-24 | 2 | 0 | Tom Browning | Mark Thurmond | Mark Thurmond | Tom Browning | Luis DeLeon | 234 | 219 | 15 |
| 1985-06-07 | vs SDN | 52 | L 2-3 | 28-24 | 2 | 37,753 | Jay Tibbs | Eric Show | Craig Lefferts | Ted Power | | 236 | 222 | 14 |
| 1985-06-08 | vs SDN | 53 | W 7-4 | 29-24 | 2 | 27,865 | Joe Price | Dave Dravecky | Joe Price | Dave Dravecky | John Franco | 243 | 226 | 17 |
| 1985-06-09 | vs SDN | 54 | L 3-5 | 29-25 | 2 | 28,971 | Mario Soto | Andy Hawkins | Andy Hawkins | Mario Soto | | 246 | 231 | 15 |
| 1985-06-10 | vs LAN | 55 | L 4-7 | 29-26 | 2 | 18,064 | John Stuper | Rick Honeycutt | Rick Honeycutt | John Stuper | Ken Howell | 250 | 238 | 12 |
| 1985-06-13 | @ ATL | 56 | W 9-2 | 30-26 | 3 | 15,814 | Jay Tibbs | Steve Shields | John Franco | Gene Garber | | 259 | 240 | 19 |
| 1985-06-14 | @ ATL | 57 | L 4-6 | 30-27 | 3 | 26,322 | Mario Soto | Zane Smith | Bruce Sutter | Mario Soto | | 263 | 246 | 17 |
| 1985-06-15 | @ ATL | 58 | L 0-7 | 30-28 | 3 | 29,635 | Joe Price | Steve Bedrosian | Steve Bedrosian | Joe Price | | 263 | 253 | 10 |
| 1985-06-16 | @ ATL | 59 | W 6-5 | 31-28 | 2 | 24,863 | Tom Browning | Rick Mahler | Ted Power | Bruce Sutter | John Franco | 269 | 258 | 11 |
| 1985-06-17 | @ SFN | 60 | L 0-4 | 31-29 | 3 | 4,916 | Jay Tibbs | Atlee Hammaker | Atlee Hammaker | Jay Tibbs | | 269 | 262 | 7 |
| 1985-06-18 | @ SFN | 61 | W 6-1 | 32-29 | 2 | 5,961 | Frank Pastore | Bill Laskey | Frank Pastore | Bill Laskey | | 275 | 263 | 12 |
| 1985-06-19 | @ SFN | 62 | L 2-5 | 32-30 | 3 | 8,490 | Mario Soto | Dave LaPoint | Dave LaPoint | Mario Soto | Scott Garrelts | 277 | 268 | 9 |
| 1985-06-21 | vs ATL | 63 | W 4-2 | 33-31 | 4 | 0 | Tom Browning | Steve Shields | Tom Browning | Steve Shields | Ted Power | 281 | 270 | 11 |
| 1985-06-21 | vs ATL | 64 | L 4-5 | 33-31 | 4 | 33,248 | Jay Tibbs | Rick Camp | Rick Camp | Jay Tibbs | Bruce Sutter | 285 | 275 | 10 |
| 1985-06-22 | vs ATL | 65 | W 4-3 | 34-31 | 3 | 20,428 | Joe Price | Zane Smith | Ron Robinson | Terry Forster | | 289 | 278 | 11 |
| 1985-06-23 | vs ATL | 66 | L 1-2 | 34-32 | 3 | 24,538 | Frank Pastore | Steve Bedrosian | Steve Bedrosian | Frank Pastore | Bruce Sutter | 290 | 280 | 10 |
| 1985-06-25 | vs SFN | 67 | W 7-6 | 35-32 | 3 | 13,952 | Mario Soto | Dave LaPoint | John Stuper | Mark Davis | Ted Power | 297 | 286 | 11 |
| 1985-06-26 | vs SFN | 68 | W 6-4 | 36-32 | 2 | 19,777 | Tom Browning | Mike Krukow | Tom Browning | Mike Krukow | Ted Power | 303 | 290 | 13 |
| 1985-06-27 | vs SFN | 69 | W 7-6 | 37-32 | 2 | 17,715 | Frank Pastore | Jim Gott | Ron Robinson | Jim Gott | Ted Power | 310 | 296 | 14 |
| 1985-06-28 | @ SDN | 70 | W 11-9 | 38-32 | 2 | 30,272 | Joe Price | Eric Show | Ron Robinson | Eric Show | Ted Power | 321 | 305 | 16 |
| 1985-06-29 | @ SDN | 71 | L 0-3 | 38-33 | 2 | 52,383 | Mario Soto | Dave Dravecky | Dave Dravecky | Mario Soto | | 321 | 308 | 13 |
| 1985-06-30 | @ SDN | 72 | W 3-2 | 39-33 | 2 | 26,895 | Tom Browning | Andy Hawkins | John Franco | Andy Hawkins | | 324 | 310 | 14 |
| 1985-07-01 | @ LAN | 73 | L 1-8 | 39-34 | 2 | 23,296 | Jay Tibbs | Orel Hershiser | Orel Hershiser | Jay Tibbs | | 325 | 318 | 7 |
| 1985-07-02 | @ LAN | 74 | L 0-3 | 39-35 | 3 | 49,207 | Joe Price | Fernando Valenzuela | Fernando Valenzuela | Joe Price | | 325 | 321 | 4 |
| 1985-07-04 | @ PHI | 75 | L 1-3 | 39-36 | 3 | 21,291 | Mario Soto | Kevin Gross | Kevin Gross | Mario Soto | | 326 | 324 | 2 |
| 1985-07-05 | @ PHI | 76 | L 2-5 | 39-37 | 3 | 25,001 | Tom Browning | Jerry Koosman | Larry Andersen | Tom Browning | Don Carman | 328 | 329 | -1 |
| 1985-07-06 | @ PHI | 77 | W 4-2 | 40-37 | 3 | 25,161 | Ron Robinson | John Denny | Ron Robinson | John Denny | Ted Power | 332 | 331 | 1 |
| 1985-07-07 | @ PHI | 78 | W 3-2 | 41-37 | 3 | 32,014 | Frank Pastore | Shane Rawley | John Franco | Kent Tekulve | Ted Power | 335 | 333 | 2 |
| 1985-07-08 | vs NYN | 79 | L 5-7 | 41-38 | 3 | 20,391 | Joe Price | Ed Lynch | Ed Lynch | Jay Tibbs | Jesse Orosco | 340 | 340 | 0 |
| 1985-07-09 | vs NYN | 80 | L 2-11 | 41-39 | 3 | 21,787 | Mario Soto | Dwight Gooden | Dwight Gooden | Mario Soto | | 342 | 351 | -9 |
| 1985-07-10 | vs NYN | 81 | L 1-2 | 41-40 | 3 | 18,958 | Tom Browning | Rick Aguilera | Rick Aguilera | Tom Browning | | 343 | 353 | -10 |
| 1985-07-11 | vs MON | 82 | W 2-0 | 42-40 | 3 | 21,150 | Ron Robinson | Joe Hesketh | Ron Robinson | Joe Hesketh | Ted Power | 345 | 353 | -8 |
| 1985-07-12 | vs MON | 83 | W 5-4 | 43-40 | 3 | 29,372 | Frank Pastore | David Palmer | John Franco | Randy St. Claire | | 350 | 357 | -7 |
| 1985-07-13 | vs MON | 84 | L 3-6 | 43-41 | 3 | 31,167 | Mario Soto | Bill Gullickson | Bill Gullickson | Mario Soto | Tim Burke | 353 | 363 | -10 |
| 1985-07-14 | vs MON | 85 | W 5-4 | 44-41 | 3 | 19,824 | Tom Browning | Bryn Smith | Ted Power | Gary Lucas | | 358 | 367 | -9 |
| 1985-07-18 | vs PHI | 86 | L 3-6 | 44-42 | 3 | 25,447 | Mario Soto | Jerry Koosman | Jerry Koosman | Mario Soto | Kent Tekulve | 361 | 373 | -12 |
| 1985-07-19 | vs PHI | 87 | W 3-2 | 45-42 | 3 | 28,929 | Tom Browning | Kevin Gross | John Franco | Kent Tekulve | | 364 | 375 | -11 |
| 1985-07-20 | vs PHI | 88 | L 6-10 | 45-43 | 3 | 33,624 | Ron Robinson | Shane Rawley | Shane Rawley | Ron Robinson | Kent Tekulve | 370 | 385 | -15 |
| 1985-07-21 | vs PHI | 89 | W 7-6 | 46-43 | 3 | 30,327 | Joe Price | John Denny | John Franco | Don Carman | Ted Power | 377 | 391 | -14 |
| 1985-07-22 | @ NYN | 90 | W 5-1 | 47-43 | 3 | 27,471 | Mario Soto | Sid Fernandez | Mario Soto | Sid Fernandez | | 382 | 392 | -10 |
| 1985-07-23 | @ NYN | 91 | W 4-0 | 48-43 | 3 | 34,720 | Tom Browning | Ron Darling | Tom Browning | Ron Darling | | 386 | 392 | -6 |
| 1985-07-24 | @ NYN | 92 | W 3-2 | 49-43 | 3 | 30,154 | Ron Robinson | Rick Aguilera | John Franco | Roger McDowell | Ted Power | 389 | 394 | -5 |
| 1985-07-25 | @ MON | 93 | L 0-1 | 49-44 | 3 | 22,366 | Andy McGaffigan | Bill Gullickson | Bill Gullickson | Tom Hume | Jeff Reardon | 389 | 395 | -6 |
| 1985-07-26 | @ MON | 94 | W 7-6 | 50-44 | 3 | 23,047 | Mario Soto | Dan Schatzeder | Bob Buchanan | Jeff Reardon | | 396 | 401 | -5 |
| 1985-07-27 | @ MON | 95 | W 7-6 | 51-44 | 3 | 25,422 | Tom Browning | David Palmer | Tom Browning | David Palmer | Tom Hume | 403 | 407 | -4 |
| 1985-07-28 | @ MON | 96 | L 0-6 | 51-45 | 3 | 27,321 | Ron Robinson | Joe Hesketh | Joe Hesketh | Ron Robinson | | 403 | 413 | -10 |
| 1985-07-30 | vs HOU | 97 | W 4-1 | 52-45 | 3 | 26,822 | Mario Soto | Nolan Ryan | Mario Soto | Nolan Ryan | | 407 | 414 | -7 |
| 1985-07-31 | vs HOU | 98 | L 2-9 | 52-46 | 3 | 20,758 | Tom Browning | Mike Scott | Mike Scott | Tom Browning | | 409 | 423 | -14 |
| 1985-08-01 | vs HOU | 99 | W 5-2 | 53-46 | 3 | 20,608 | Andy McGaffigan | Bob Knepper | Andy McGaffigan | Bob Knepper | | 414 | 425 | -11 |
| 1985-08-02 | vs LAN | 100 | L 3-5 | 54-47 | 2 | 0 | Ron Robinson | Orel Hershiser | Orel Hershiser | Ron Robinson | Tom Niedenfuer | 417 | 430 | -13 |
| 1985-08-02 | vs LAN | 101 | W 5-2 | 54-47 | 2 | 40,236 | Jay Tibbs | Rick Honeycutt | Jay Tibbs | Rick Honeycutt | | 422 | 432 | -10 |
| 1985-08-03 | vs LAN | 102 | L 0-2 | 54-48 | 2 | 38,474 | Mario Soto | Bob Welch | Bob Welch | Mario Soto | | 422 | 434 | -12 |
| 1985-08-04 | vs LAN | 103 | W 5-4 | 55-48 | 2 | 39,049 | Tom Browning | Fernando Valenzuela | Ted Power | Ken Howell | | 427 | 438 | -11 |
| 1985-08-05 | vs SDN | 104 | W 8-7 | 56-48 | 2 | 24,622 | Andy McGaffigan | Andy Hawkins | Tom Hume | Roy Lee Jackson | Ted Power | 435 | 445 | -10 |
| 1985-08-08 | @ LAN | 105 | W 6-5 | 57-48 | 2 | 37,479 | Mario Soto | Orel Hershiser | Ted Power | Carlos Diaz | Ron Robinson | 441 | 450 | -9 |
| 1985-08-09 | @ LAN | 106 | L 1-3 | 57-49 | 2 | 44,935 | Tom Browning | Bob Welch | Bob Welch | Tom Browning | | 442 | 453 | -11 |
| 1985-08-10 | @ LAN | 107 | L 1-2 | 57-50 | 2 | 48,410 | Jay Tibbs | Fernando Valenzuela | Fernando Valenzuela | Jay Tibbs | | 443 | 455 | -12 |
| 1985-08-11 | @ LAN | 108 | L 0-4 | 57-51 | 2 | 41,188 | Andy McGaffigan | Jerry Reuss | Jerry Reuss | Andy McGaffigan | | 443 | 459 | -16 |
| 1985-08-12 | @ SDN | 109 | L 0-2 | 57-52 | 3 | 35,521 | Mario Soto | Mark Thurmond | Mark Thurmond | Mario Soto | Lance McCullers | 443 | 461 | -18 |
| 1985-08-13 | @ SDN | 110 | W 3-2 | 58-52 | 2 | 22,582 | Tom Browning | LaMarr Hoyt | Tom Browning | LaMarr Hoyt | John Franco | 446 | 463 | -17 |
| 1985-08-14 | @ SDN | 111 | L 1-4 | 58-53 | 3 | 21,028 | Jay Tibbs | Dave Dravecky | Dave Dravecky | Jay Tibbs | | 447 | 467 | -20 |
| 1985-08-15 | @ SDN | 112 | W 5-4 | 59-53 | 2 | 19,973 | Andy McGaffigan | Eric Show | John Franco | Gene Walter | Joe Price | 452 | 471 | -19 |
| 1985-08-16 | @ HOU | 113 | L 4-5 | 59-54 | 3 | 17,483 | Mario Soto | Bob Knepper | Dave Smith | Ted Power | | 456 | 476 | -20 |
| 1985-08-17 | @ HOU | 114 | W 8-0 | 60-54 | 3 | 22,703 | Tom Browning | Joe Niekro | Tom Browning | Joe Niekro | | 464 | 476 | -12 |
| 1985-08-18 | @ HOU | 115 | W 8-3 | 61-54 | 2 | 14,216 | Jay Tibbs | Nolan Ryan | Jay Tibbs | Nolan Ryan | John Franco | 472 | 479 | -7 |
| 1985-08-20 | @ PIT | 116 | L 2-3 | 61-55 | 3 | 7,827 | Mario Soto | Rick Reuschel | Rick Reuschel | Mario Soto | | 474 | 482 | -8 |
| 1985-08-21 | @ PIT | 117 | W 8-5 | 62-55 | 3 | 17,198 | Tom Browning | Bob Walk | Tom Browning | Bob Walk | John Franco | 482 | 487 | -5 |
| 1985-08-22 | @ PIT | 118 | L 1-5 | 62-56 | 3 | 10,437 | Jay Tibbs | Rick Rhoden | Rick Rhoden | Jay Tibbs | Rod Scurry | 483 | 492 | -9 |
| 1985-08-23 | vs CHN | 119 | W 3-2 | 63-56 | 3 | 34,283 | Andy McGaffigan | Jay Baller | John Franco | Lary Sorensen | | 486 | 494 | -8 |
| 1985-08-24 | vs CHN | 120 | L 0-4 | 63-57 | 3 | 37,069 | Mario Soto | Steve Trout | George Frazier | Mario Soto | Lee Smith | 486 | 498 | -12 |
| 1985-08-25 | vs CHN | 121 | W 5-3 | 64-57 | 3 | 35,038 | Tom Browning | Ray Fontenot | Tom Browning | Warren Brusstar | John Franco | 491 | 501 | -10 |
| 1985-08-26 | vs SLN | 122 | L 0-3 | 64-58 | 3 | 28,071 | Jay Tibbs | Danny Cox | Danny Cox | Jay Tibbs | | 491 | 504 | -13 |
| 1985-08-27 | vs SLN | 123 | L 4-6 | 64-59 | 3 | 22,268 | Andy McGaffigan | John Tudor | Bill Campbell | Ted Power | Jeff Lahti | 495 | 510 | -15 |
| 1985-08-28 | vs SLN | 124 | W 7-6 | 65-59 | 3 | 21,049 | Mario Soto | Joaquin Andujar | Ted Power | Jeff Lahti | | 502 | 516 | -14 |
| 1985-08-29 | vs PIT | 125 | W 6-0 | 66-59 | 3 | 18,789 | Tom Browning | Jose DeLeon | Tom Browning | Jose DeLeon | | 508 | 516 | -8 |
| 1985-08-30 | vs PIT | 126 | W 1-0 | 67-59 | 3 | 21,253 | Jay Tibbs | Rick Reuschel | Jay Tibbs | Rick Reuschel | | 509 | 516 | -7 |
| 1985-08-31 | vs PIT | 127 | L 0-6 | 67-60 | 3 | 28,656 | Andy McGaffigan | Bob Walk | Bob Walk | Andy McGaffigan | | 509 | 522 | -13 |
| 1985-09-01 | vs PIT | 128 | W 3-2 | 68-60 | 3 | 30,062 | Mario Soto | Rick Rhoden | Mario Soto | Rod Scurry | John Franco | 512 | 524 | -12 |
| 1985-09-02 | @ SLN | 129 | W 4-1 | 69-60 | 2 | 29,026 | Tom Browning | Joaquin Andujar | Tom Browning | Joaquin Andujar | John Franco | 516 | 525 | -9 |
| 1985-09-03 | @ SLN | 130 | L 4-6 | 69-61 | 2 | 19,261 | Jay Tibbs | Bob Forsch | Jeff Lahti | Tom Hume | | 520 | 531 | -11 |
| 1985-09-04 | @ SLN | 131 | L 3-4 | 69-62 | 2 | 25,425 | Andy McGaffigan | Kurt Kepshire | Todd Worrell | Ron Robinson | | 523 | 535 | -12 |
| 1985-09-06 | @ CHN | 132 | W 7-5 | 70-62 | 2 | 17,026 | Mario Soto | Derek Botelho | Mario Soto | Derek Botelho | | 530 | 540 | -10 |
| 1985-09-07 | @ CHN | 133 | L 7-9 | 70-63 | 2 | 30,300 | Tom Browning | Dennis Eckersley | Jay Baller | John Franco | | 537 | 549 | -12 |
| 1985-09-08 | @ CHN | 134 | L 5-5 | 70-64 | 2 | 28,269 | Jay Tibbs | Reggie Patterson | | | | 542 | 554 | -12 |
| 1985-09-09 | vs SDN | 135 | W 2-1 | 71-64 | 2 | 29,289 | Andy McGaffigan | Dave Dravecky | John Franco | Rich Gossage | | 544 | 555 | -11 |
| 1985-09-10 | vs SDN | 136 | L 2-3 | 71-65 | 2 | 51,045 | Ron Robinson | LaMarr Hoyt | LaMarr Hoyt | Ron Robinson | Rich Gossage | 546 | 558 | -12 |
| 1985-09-11 | vs SDN | 137 | W 2-0 | 72-65 | 2 | 47,237 | Tom Browning | Eric Show | Tom Browning | Eric Show | Ted Power | 548 | 558 | -10 |
| 1985-09-12 | vs SDN | 138 | W 2-1 | 73-65 | 2 | 13,418 | Jay Tibbs | Andy Hawkins | Jay Tibbs | Andy Hawkins | Ted Power | 550 | 559 | -9 |
| 1985-09-13 | vs LAN | 139 | L 2-8 | 74-66 | 2 | 0 | Andy McGaffigan | Orel Hershiser | Orel Hershiser | Andy McGaffigan | | 552 | 567 | -15 |
| 1985-09-13 | vs LAN | 140 | W 6-5 | 74-66 | 2 | 28,961 | Mario Soto | Alejandro Pena | Ted Power | Tom Niedenfuer | | 558 | 572 | -14 |
| 1985-09-14 | vs LAN | 141 | L 0-7 | 74-67 | 2 | 29,771 | Ron Robinson | Bob Welch | Bob Welch | Ron Robinson | | 558 | 579 | -21 |
| 1985-09-15 | vs LAN | 142 | W 10-6 | 75-67 | 2 | 28,804 | Tom Browning | Fernando Valenzuela | Tom Browning | Fernando Valenzuela | Ted Power | 568 | 585 | -17 |
| 1985-09-16 | vs SFN | 143 | W 7-6 | 76-67 | 2 | 13,045 | Jay Tibbs | Jim Gott | John Stuper | Mark Davis | | 575 | 591 | -16 |
| 1985-09-17 | vs SFN | 144 | W 6-1 | 77-67 | 2 | 11,521 | Andy McGaffigan | Dave LaPoint | Andy McGaffigan | Dave LaPoint | | 581 | 592 | -11 |
| 1985-09-18 | @ ATL | 145 | W 7-3 | 78-67 | 2 | 6,581 | Ron Robinson | Len Barker | Ron Robinson | Len Barker | | 588 | 595 | -7 |
| 1985-09-19 | @ ATL | 146 | W 15-5 | 79-67 | 2 | 5,160 | Tom Browning | Pascual Perez | Tom Browning | Pascual Perez | | 603 | 600 | 3 |
| 1985-09-20 | @ HOU | 147 | W 5-3 | 80-67 | 2 | 14,776 | Jay Tibbs | Nolan Ryan | Jay Tibbs | Nolan Ryan | Ted Power | 608 | 603 | 5 |
| 1985-09-21 | @ HOU | 148 | L 5-9 | 80-68 | 2 | 9,582 | Andy McGaffigan | Jeff Heathcock | Dave Smith | John Franco | | 613 | 612 | 1 |
| 1985-09-22 | @ HOU | 149 | W 6-5 | 81-68 | 2 | 10,181 | Ron Robinson | Charlie Kerfeld | Ted Power | Bill Dawley | | 619 | 617 | 2 |
| 1985-09-24 | vs ATL | 150 | W 7-5 | 82-68 | 2 | 14,947 | Tom Browning | Pascual Perez | Tom Browning | Pascual Perez | Ted Power | 626 | 622 | 4 |
| 1985-09-25 | vs ATL | 151 | L 2-4 | 82-69 | 2 | 14,981 | Jay Tibbs | Rick Mahler | Gene Garber | Ted Power | Rick Camp | 628 | 626 | 2 |
| 1985-09-26 | vs ATL | 152 | W 6-1 | 83-69 | 2 | 10,454 | Andy McGaffigan | Steve Bedrosian | Andy McGaffigan | Steve Bedrosian | Ted Power | 634 | 627 | 7 |
| 1985-09-27 | vs HOU | 153 | W 4-3 | 84-69 | 2 | 19,178 | Ron Robinson | Jeff Heathcock | Ron Robinson | Jeff Calhoun | John Franco | 638 | 630 | 8 |
| 1985-09-28 | vs HOU | 154 | W 5-2 | 85-69 | 2 | 19,088 | Tom Browning | Mike Scott | Tom Browning | Mike Scott | Ted Power | 643 | 632 | 11 |
| 1985-09-29 | vs HOU | 155 | W 5-0 | 86-69 | 2 | 33,317 | Jay Tibbs | Bob Knepper | Jay Tibbs | Bob Knepper | | 648 | 632 | 16 |
| 1985-09-30 | @ SFN | 156 | L 3-4 | 86-70 | 2 | 2,152 | Mario Soto | Vida Blue | Scott Garrelts | Ted Power | | 651 | 636 | 15 |
| 1985-10-01 | @ SFN | 157 | W 7-6 | 87-70 | 2 | 2,483 | Andy McGaffigan | Atlee Hammaker | Tom Hume | Scott Garrelts | John Franco | 658 | 642 | 16 |
| 1985-10-02 | @ SDN | 158 | L 4-5 | 87-71 | 2 | 12,373 | Tom Browning | Eric Show | Rich Gossage | Tom Hume | | 662 | 647 | 15 |
| 1985-10-03 | @ SDN | 159 | L 4-9 | 87-72 | 2 | 8,698 | Jay Tibbs | Andy Hawkins | Andy Hawkins | Jay Tibbs | | 666 | 656 | 10 |
| 1985-10-04 | @ LAN | 160 | W 4-2 | 88-72 | 2 | 43,309 | John Stuper | Fernando Valenzuela | John Stuper | Alejandro Pena | Ted Power | 670 | 658 | 12 |
| 1985-10-05 | @ LAN | 161 | L 1-3 | 88-73 | 2 | 35,861 | Ron Robinson | Bob Welch | Bob Welch | Ron Robinson | Tom Niedenfuer | 671 | 661 | 10 |
| 1985-10-06 | @ LAN | 162 | W 6-5 | 89-73 | 2 | 45,778 | Tom Browning | Dennis Powell | Ted Power | Tom Niedenfuer | John Franco | 677 | 666 | 11 |